CN107028848A - A kind of disinfection solution of disposable hand natural green - Google Patents
A kind of disinfection solution of disposable hand natural green Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The present invention relates to disinfectant technical field, and in particular to a kind of disinfection solution of disposable hand natural green, includes the component of following mass percent：Poly hexamethylene biguanide 0.4 0.8%, antibacterial peptide 0.2 0.5%, catechin 0.5 1%, moisturizing agent 1 2%, handguard agent 0.8 1.2%, glycerine 1 2%, Chinese herbal medicine extract 3 5%, cosolvent 2 3.5%, thickener 0.1 0.25%, pH adjusting agent 0.1 0.5%, ethanol 30 40%, deionized water surplus.The disinfection solution that the present invention is provided, major antibacterial effect is played with poly hexamethylene biguanide, and poly hexamethylene biguanide is nontoxic, can further strengthen bactericidal effect with antibacterial peptide compounding, so as to reduce the consumption of ethanol.Rationally coordinate between each component of disinfection solution, interact, make it have broad spectrum activity, can effectively kill a variety of bacterium, the disinfection effect duration is long, safe and efficient, protect hand skin.
Description
Technical field
The present invention relates to disinfectant technical field, and in particular to a kind of disinfection solution of disposable hand natural green.
Background technology
Skin it is parasitic various microorganisms, including various bacterial propagules, fungi, germ etc., especially hand
Skin, because the chance that it contacts article is more, the type and quantity of contaminating microorganisms are also most, particularly medical personnel's hand
Germ contamination it is even more serious, if sterilization not thoroughly will to oneself, patient and household bring disease risk, therefore, effectively
Timely skin is carried out disinfection, propagated for prevention disease, controls the generation of inside-hospital infection event significant.
In the sterilization for carrying out hand skin before mainly using soap, perfumed soap etc., easily slid when they use, meet water
Leaching, high temperature can soften and expend naturally again, the especially easy dirt being infected with hand, bacterium, as pollution source.Therefore, wash
Hand liquid is widely used in various places such as hospital, hotel, dining room, families.Maturation and market with hand cleanser production technology
Popularization, the special hand cleanser with various special efficacies constantly comes out, wherein, during disinfection hand cleanser is market hand cleanser
The maximum class of occupancy volume.Disposable hand disinfection solution is one kind therein, and it does not need water to rinse with regard to that can play what is washed one's hands
Effect, compared with general hand cleanser, disposable hand disinfection solution is not limited by water source, is particularly suitable for the opponent under water deficit conditions
Portion is cleaned and sterilization is used, and is particularly suitable for use in some in outside work or the crowd of outdoor travel.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, polymer is held into electropositive
Easily adsorbed by bacterium, virus, directly act on microorganism, it is suppressed that bacterium, the division copy function of virus, it is in microorganism
The formation of body surface polymer plugs the respiration channel of microorganism, microorganism is choked to death.Meanwhile, its high molecular polymer knot
Structure is improved the effective active of guanidine radicals, and bacterium is not likely to produce drug resistance.Poly hexamethylene biguanide little effect on the human body, be
A kind of non-toxic disinfectant.Poly hexamethylene biguanide has the fast effect of antivirus effect, is very suitable for Quick disinfection.
Hand cleanser at present on the market is varied, but the antivirus effect mostly for certain bacterium is notable, bactericidal effect list
One, do not possess broad-spectrum.Moreover, the fast material that in general volatilizees, can take away the moisture of skin, hand skin can be produced
Raw excitant, accordingly, it would be desirable to a kind of good and non-stimulated to the hand skin disposable hand disinfection solution of bactericidal effect.
The content of the invention
It is an object of the invention to provide a kind of good and non-stimulated to the hand skin disposable hand natural green of bactericidal effect
Disinfection solution, various sterilization material is compounded, and improves bactericidal effect, extends the duration of bactericidal effect, and can protect hand
Portion's skin.
To achieve the above object, the technical solution adopted by the present invention is：
A kind of disinfection solution of disposable hand natural green, includes the component of following mass percent：
It is further preferred that described antibacterial peptide is Nap-Phe-Phe-Lys-Pro-Leu-Gly-Leu-Ala-Arg-
Lys (Nap-FFKPLGLARK), the antibacterial peptide is a kind of cationic amphiphic small peptide, can kill Gram-negative bacteria, is had
There is bactericidal action, it can be compounded after adding with poly hexamethylene biguanide, expand the bactericidal range of disinfection solution, further carry
Its high bactericidal activity；And in one layer of protection gel mould of skin formation, it can be extended and sterilize timeliness.
It is further preferred that the Chinese herbal medicine extract includes composition by weight：10-15 parts of corter pseudolaricis, the tuber of stemona
5-10 parts, 5-10 parts of selfheal, 10-15 parts of the Bi roots of grass, 5-10 parts of dittany bark, 10-15 parts of peppermint, 10-15 parts of the Radix Astragali, fruit of summer cypress 5-
10 parts, 1-5 parts of cordate houttuynia.The Chinese herbal medicine of selection is non-stimulated to skin, each other can be with compatibility, wherein as corter pseudolaricis, summer are withered
Grass, Radix Astragali etc. have antibacterial activity, and the tuber of stemona, dittany bark etc. has the drug effects such as clearing heat and detoxicating, alleviation skin discomfort, it is possible to reduce right
The injury of skin, improves the bactericidal effect of thimerosal, and protection is provided to skin.
It is further preferred that described moisturizing agent is Aloe Vera Gel, handguard agent is deep-sea shark oil.Aloe Vera Gel is anti-except itself
The effect of bacterium antivirus, is also to play the role of moisturizing to alleviate volatilization so that disinfectant can keep the sterilization of long period, and aloe
Glue has the effect for skin of releiving.The sebum structure of deep-sea shark oil and the mankind have perfect compatible and highly stable, tool
There is the penetration of strength, it can soft skin, softening dead skin and effective microgroove and scar, also good sterilizing function of declining.
It is further preferred that the pH adjusting agent is triethanolamine.
It is further preferred that the cosolvent be Tween-20, Cremophor RH40, Cocoamidopropyl betaine,
One or more in APG, empgen BB.
It is further preferred that the thickener be cocoanut fatty acid diethanolamide, carbomer, hydroxyethyl cellulose,
One or more in hydroxypropyl cellulose.
Present invention also offers a kind of preparation method of the disinfection solution of disposable hand natural green：Xiang Shuizhong is sequentially added
Poly hexamethylene biguanide, moisturizing agent, Chinese herbal medicine extract, are well mixed, obtain the aqueous solution；Catechu is sequentially added into ethanol
Element, handguard agent, glycerine, are well mixed, obtain ethanol solution；Ethanol solution is sequentially added into the aqueous solution, water is had been dissolved in
Thickener and cosolvent, are eventually adding antibacterial peptide, and deionized water is supplied, and pH to 6-8 is adjusted with pH adjusting agent.
Further, the preparation method of the Chinese herbal medicine extract is：Chinese herbal medicine is weighed by weight, is crushed respectively
Sieve, wherein the tuber of stemona, selfheal, dittany bark, peppermint, the Radix Astragali, the fruit of summer cypress, cordate houttuynia are mixed, is boiled with decocting, filtered, obtain water
Extract solution, corter pseudolaricis, the tuber of stemona, the Bi roots of grass are extracted with alcohol reflux, ethanol extract are obtained, by aqueous extract and ethanol extract
Mixing, decolourizes, and filters, and concentration obtains Chinese herbal medicine extract.
Compared with prior art, the beneficial effects of the invention are as follows：
The disinfection solution that the present invention is provided, major antibacterial effect is played with poly hexamethylene biguanide, and polyhexamethylene is double
Guanidine is nontoxic, does not have toxicity to human body and environment, and green is friendly, and bactericidal effect can be further strengthened with antibacterial peptide compounding,
So as to reduce the consumption of ethanol.Rationally coordinate between each component of disinfection solution, interact, make it have broad spectrum activity, energy
Enough effectively to kill a variety of bacterium, the disinfection effect duration is long, safe and efficient, protects hand skin.
Embodiment
With reference to specific embodiment, the present invention is further illustrated, but is not limited thereto.
Embodiment 1
A kind of disinfection solution of disposable hand natural green, including following components：
Weigh：10 parts of corter pseudolaricis, 5 parts of the tuber of stemona, 5 parts of selfheal, 10 parts of the Bi roots of grass, 5 parts of dittany bark, 10 parts of peppermint, the Radix Astragali 10
Part, 5 parts of the fruit of summer cypress, 1 part of cordate houttuynia, pulverize and sieve respectively, wherein by the tuber of stemona, selfheal, dittany bark, peppermint, the Radix Astragali, summer cypress
Son, cordate houttuynia mixing, are boiled with decocting, filtered, obtained aqueous extract, corter pseudolaricis, the tuber of stemona, the Bi roots of grass are extracted with alcohol reflux, obtained
Ethanol extract is obtained, aqueous extract is mixed with ethanol extract, with activated carbon decolorizing, is filtered, concentration, Chinese herbal medicine extraction is obtained
Thing.
Xiang Shuizhong sequentially adds 4g poly hexamethylene biguanides, 10g moisturizing agents, 30g Chinese herbal medicine extracts, is well mixed, obtains
To the aqueous solution；5g catechins, the agent of 8g handguards, 10g glycerine are sequentially added into ethanol, is well mixed, obtains ethanol solution；Xiang Shui
Ethanol solution is sequentially added in solution, the 1g thickeners and 20g cosolvents of water is had been dissolved in, 2g antibacterial peptides is eventually adding, supplies
Deionized water is stirred to 1kg, and pH to 6 is adjusted with pH adjusting agent.
Embodiment 2
A kind of disinfection solution of disposable hand natural green, including following components：
Weigh：15 parts of corter pseudolaricis, 10 parts of the tuber of stemona, 10 parts of selfheal, 15 parts of the Bi roots of grass, 10 parts of dittany bark, 15 parts of peppermint, the Radix Astragali
15 parts, 10 parts of the fruit of summer cypress, 5 parts of cordate houttuynia, pulverize and sieve respectively, wherein by the tuber of stemona, selfheal, dittany bark, peppermint, the Radix Astragali,
Skin, cordate houttuynia mixing, are boiled with decocting, filtered, obtained aqueous extract, corter pseudolaricis, the tuber of stemona, the Bi roots of grass are extracted with alcohol reflux,
Ethanol extract is obtained, aqueous extract is mixed with ethanol extract, with activated carbon decolorizing, is filtered, concentration obtains Chinese herbal medicine and carried
Take thing.
Xiang Shuizhong sequentially adds 8g poly hexamethylene biguanides, 10g Aloe Vera Gels, 50g Chinese herbal medicine extracts, is well mixed, obtains
To the aqueous solution；10g catechins, 12g deep-seas shark oil, 20g glycerine are sequentially added into ethanol, is well mixed, obtains ethanol solution；
Sequentially added into the aqueous solution ethanol solution, oneself be dissolved in water 2.5g cocoanut fatty acid diethanolamides and 35g tweens-
20,5g Nap-FFKPLGLARK are eventually adding, deionized water is supplied to 1kg, stirs, pH to 7 is adjusted with triethanolamine.
Embodiment 3
A kind of disinfection solution of disposable hand natural green, including following components：
Weigh：12 parts of corter pseudolaricis, 6 parts of the tuber of stemona, 6 parts of selfheal, 12 parts of the Bi roots of grass, 6 parts of dittany bark, 12 parts of peppermint, the Radix Astragali 12
Part, 6 parts of the fruit of summer cypress, 2 parts of cordate houttuynia, pulverize and sieve respectively, wherein by the tuber of stemona, selfheal, dittany bark, peppermint, the Radix Astragali, summer cypress
Son, cordate houttuynia mixing, are boiled with decocting, filtered, obtained aqueous extract, corter pseudolaricis, the tuber of stemona, the Bi roots of grass are extracted with alcohol reflux, obtained
Ethanol extract is obtained, aqueous extract is mixed with ethanol extract, with activated carbon decolorizing, is filtered, concentration, Chinese herbal medicine extraction is obtained
Thing.
Xiang Shuizhong sequentially adds 5g poly hexamethylene biguanides, 12g Aloe Vera Gels, 40g Chinese herbal medicine extracts, is well mixed, obtains
To the aqueous solution；6g catechins, 9g deep-seas shark oil, 15g glycerine are sequentially added into ethanol, is well mixed, obtains ethanol solution；To
Ethanol solution is sequentially added in the aqueous solution, the 1.2g carbomers and 25g Cremophor RH40s of water is had been dissolved in, finally added
Enter 3g Nap-FFKPLGLARK, supply deionized water to 1kg, stir, pH to 8 is adjusted with triethanolamine.
Embodiment 4
A kind of disinfection solution of disposable hand natural green, including following components：
Weigh：13 parts of corter pseudolaricis, 7 parts of the tuber of stemona, 7 parts of selfheal, 13 parts of the Bi roots of grass, 6 parts of dittany bark, 12 parts of peppermint, the Radix Astragali 12
Part, 7 parts of the fruit of summer cypress, 2 parts of cordate houttuynia, pulverize and sieve respectively, wherein by the tuber of stemona, selfheal, dittany bark, peppermint, the Radix Astragali, summer cypress
Son, cordate houttuynia mixing, are boiled with decocting, filtered, obtained aqueous extract, corter pseudolaricis, the tuber of stemona, the Bi roots of grass are extracted with alcohol reflux, obtained
Ethanol extract is obtained, aqueous extract is mixed with ethanol extract, with activated carbon decolorizing, is filtered, concentration, Chinese herbal medicine extraction is obtained
Thing.
Xiang Shuizhong sequentially adds 6g poly hexamethylene biguanides, 15g Aloe Vera Gels, 40g Chinese herbal medicine extracts, is well mixed, obtains
To the aqueous solution；7.5g catechins, 10g deep-seas shark oil, 15g glycerine are sequentially added into ethanol, is well mixed, obtains ethanol molten
Liquid；Sequentially added into the aqueous solution ethanol solution, oneself be dissolved in the 1.8g hydroxyethyl celluloses and 28g APGs of water, finally
4g Nap-FFKPLGLARK are added, deionized water is supplied to 1kg, stirs, pH to 8 is adjusted with triethanolamine.
The compound synergic of test example 1 is tested
According to《Disinfection technology standard》The test method of (2002 editions), the antiseptic property detected using quantitative disinfecting test.
Test result table 1.Poly hexamethylene biguanide is component A in table 1, and Nap-FFKPLGLARK is component B, and catechin is component C.
The killing logarithm value of the Escherichia coli insect killing test of table 1
| Action time | 0.5min | 1min |
| Component A: component B: component C (1: 1: 1) | ＞ 5 | ＞ 5 |
| Component A: component B: component C (2: 1: 2) | ＞ 5 | ＞ 5 |
| Component A: component B: component C (2: 1: 3) | ＞ 5 | ＞ 5 |
| Component A: component B (1: 1) | 3.81 | 4.59 |
| Component A: component B (2: 1) | 4.77 | ＞ 5 |
| Component A: component C (1: 1) | 3.71 | 4.55 |
| Component A: component C (2: 1) | 3.88 | ＞ 5 |
| Component A | 1.06 | 1.82 |
| Component B | 0.21 | 0.56 |
| Component C | 0.18 | 0.37 |
As shown in Table 1, poly hexamethylene biguanide, Nap-FFKPLGLARK, the bactericidal action of catechin three compounding are better than
The bactericidal action that poly hexamethylene biguanide is compounded with Nap-FFKPLGLARK, catechin respectively, the sterilization of better than each single dose is made
With showing to serve the effect of Synergistic between three.
The irritation test of test example 2
Using multiple intact skin irritant test, embodiment 1-4 is to the multiple intact skin stimulus intensity of new zealand rabbit for detection
Whether to there is excitant.
The both sides local skin reaction of tested new zealand rabbit is observed during experiment and after experiment, observation result is the new west of experiment
Blue rabbit both sides skin is without other malaise symptoms such as red and swollen and erythema, and scoring is 0, show embodiment 1-4 to hand skin without
Excitant.
The ageing experiment of test example 3
Subject is divided into 3 big groups, respectively 4h groups, 5h groups and 6h groups, is 4 groups by big component, embodiment is used respectively
1-4 is sterilized to subject's hand skin, then determines killing logarithm value average value during 4h group 4h, 5h groups and 6h groups are ibid.
Before sterilization, after the mutual rubbing of subject's both hands, the five fingers close up, with sterile cotton swab the dilution containing 10ml test tube
Sampling end is cut into original in sterile working mode from finger tip to root double rub is referred to 2 times in middle adhesional wetting, face that its left hand the five fingers is counted on one's fingers
In dilution test tube, positive controls are used as.After sampling, opponent carries out disinfection processing, after corresponding action time, uses sterile cotton
Swab is bedewed in containing 10ml and in the test tube of agent solution, and its right hand is sampled with same procedure, sterilization group is used as.Will be right
Fully beaten according to group and sterilization group sample liquid and 1.0ml inoculation plates are drawn with acceptable diluent degree, in duplicate, after each group inoculation plate
TSA culture mediums are poured into, after condensation, is placed in together with nonvaccinated experiment with culture medium flat plate in 37 DEG C of incubators and cultivates 48h,
Surviving colonies number is counted, calculates and kills logarithm value, result of the test is shown in Table 2.
The disinfection solution of table 2 is to the ageing result of the test of hand skin degerming
| The killing logarithm value of 4h groups | The killing logarithm value of 5h groups | The killing logarithm value of 6h groups | |
| Embodiment 1 | 3.43 | 2.56 | 1.78 |
| Embodiment 2 | 3.80 | 2.95 | 1.18 |
| Embodiment 3 | 3.89 | 2.09 | 1.11 |
| Embodiment 4 | 3.69 | 2.63 | 1.71 |
As shown in Table 2, embodiment 1-4 is respectively provided with good sterilizing effect to hand skin, and its action effect with
The growth of time and weaken, but each embodiment still has certain antibacterial action in 6h to hand skin.
Although having done more detailed elaboration to technical scheme and having enumerated, it will be appreciated that for ability
For field technique personnel, modification is made to above-described embodiment or equivalent alternative solution is used, this is to those skilled in the art
It is it is clear that these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the present invention for member
Claimed scope.
Claims (9)
1. a kind of disinfection solution of disposable hand natural green, it is characterised in that include the component of following mass percent：
2. a kind of disinfection solution of disposable hand natural green according to claim 1, it is characterised in that described antibacterial
Peptide is Nap-Phe-Phe-Lys-Pro-Leu-Gly-Leu-Ala-Arg-Lys.
3. a kind of disinfection solution of disposable hand natural green according to claim 1, it is characterised in that the Chinese herbal medicine
Extract includes composition by weight：10-15 parts of corter pseudolaricis, 5-10 parts of the tuber of stemona, 5-10 parts of selfheal, 10-15 parts of the Bi roots of grass,
5-10 parts of dittany bark, 10-15 parts of peppermint, 10-15 parts of the Radix Astragali, 5-10 parts of the fruit of summer cypress, 1-5 parts of cordate houttuynia.
4. the disinfection solution of a kind of disposable hand natural green according to claim 1, it is characterised in that described moistens
Agent is Aloe Vera Gel, and handguard agent is deep-sea shark oil.
5. a kind of disinfection solution of disposable hand natural green according to claim 1, it is characterised in that the pH regulations
Agent is triethanolamine.
6. a kind of disinfection solution of disposable hand natural green according to claim 1, it is characterised in that the cosolvent
For one kind in Tween-20, Cremophor RH40, Cocoamidopropyl betaine, APG, empgen BB
Or it is several.
7. a kind of disinfection solution of disposable hand natural green according to claim 1, it is characterised in that the thickener
For the one or more in cocoanut fatty acid diethanolamide, carbomer, hydroxyethyl cellulose, hydroxypropyl cellulose.
8. a kind of preparation method of the disinfection solution of disposable hand natural green, it is characterised in that poly- six are sequentially added into water
Methylene biguanides, moisturizing agent, Chinese herbal medicine extract, are well mixed, obtain the aqueous solution；Catechin, shield are sequentially added into ethanol
Hand agent, glycerine, are well mixed, obtain ethanol solution；Ethanol solution is sequentially added into the aqueous solution, the thickener of water is had been dissolved in
And cosolvent, antibacterial peptide is eventually adding, deionized water is supplied, pH to 6-8 is adjusted with pH adjusting agent.
9. a kind of disinfection solution of disposable hand natural green according to claim 8, it is characterised in that the Chinese herbal medicine
The preparation method of extract is：Chinese herbal medicine is weighed by weight, is pulverized and sieved respectively, wherein by the tuber of stemona, selfheal, dittany
Skin, peppermint, the Radix Astragali, the fruit of summer cypress, cordate houttuynia mixing, are boiled with decocting, filtered, aqueous extract is obtained, by corter pseudolaricis, the tuber of stemona, the Bi roots of grass
Extracted with alcohol reflux, obtain ethanol extract, aqueous extract is mixed with ethanol extract, decolourized, filtered, concentration is obtained
Chinese herbal medicine extract.
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Cited By (9)
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|---|---|---|---|---|
| CN110585093A (en) * | 2019-11-01 | 2019-12-20 | 信阳学院 | Hand-washing-free disinfection gel containing natural green tea extract and preparation method thereof |
| CN111329820A (en) * | 2020-03-05 | 2020-06-26 | 辽宁东科药业有限公司 | Hand disinfectant with moisturizing and deodorizing functions and preparation method thereof |
| CN111602656A (en) * | 2020-06-11 | 2020-09-01 | 卓敏 | Multifunctional compound disinfectant and preparation method thereof |
| CN111840122A (en) * | 2020-08-14 | 2020-10-30 | 上海黛龙生物工程科技有限公司 | Sterilizing and disinfecting composition and preparation method thereof |
| CN111991317A (en) * | 2020-09-21 | 2020-11-27 | 青岛格林维尔环保技术有限公司 | Hand-washing-free gel containing Chinese herbal medicine components and preparation method thereof |
| CN112370394A (en) * | 2020-12-10 | 2021-02-19 | 青岛格林维尔环保技术有限公司 | Hydrogen-rich water-containing hand-washing-free disinfection gel and preparation method thereof |
| CN113081881A (en) * | 2020-04-10 | 2021-07-09 | 杭州睿道医药科技有限公司 | Antibacterial and antiviral wash-free hand sanitizer and preparation method thereof |
| CN113456536A (en) * | 2021-07-08 | 2021-10-01 | 四川大学 | Alcohol-free skin-care washing-free disinfectant and preparation method thereof |
| CN113940895A (en) * | 2020-07-15 | 2022-01-18 | 南京星银药业集团有限公司 | Antibacterial peptide hand sanitizer and preparation method thereof |
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| CN111602656A (en) * | 2020-06-11 | 2020-09-01 | 卓敏 | Multifunctional compound disinfectant and preparation method thereof |
| CN113940895A (en) * | 2020-07-15 | 2022-01-18 | 南京星银药业集团有限公司 | Antibacterial peptide hand sanitizer and preparation method thereof |
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