CN108404062B - Traditional Chinese medicine composition for treating hyperlipidemia and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating hyperlipidemia and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with a function of treating hyperlipemia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-8 parts of ginseng, 8-18 parts of turmeric, 6-14 parts of bighead atractylodes rhizome, 6-14 parts of dried orange peel, 6-14 parts of cattail pollen, 5-12 parts of lotus leaf, 5-12 parts of rhizoma alismatis, 5-12 parts of kelp, 5-12 parts of cassia seed and 5-12 parts of hawthorn. The traditional Chinese medicine composition disclosed by the invention can be used for treating hyperlipidemia and has a remarkable effect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition with a function of treating hyperlipidemia, and also relates to a preparation method and application of the composition.
Background
Hyperlipidemia, also known as hyperlipidemia or hyperlipoproteinemia, is a condition in which the plasma lipid concentration exceeds the normal upper limit. Blood lipid concentrations are affected by a variety of factors: cholesterol and triglycerides may increase with age; much meat is eaten more than long-term vegetable; patients with polyphagia of animal oil or cholesterol-rich food often have elevated blood cholesterol levels; the triglyceride level is often high in the case of polyphagia. In addition, hyperlipidemia is also common in a variety of diseases such as uncontrolled diabetes, hypothyroidism, atherosclerosis, coronary heart disease, stroke, nephrotic syndrome and certain inherited lipid metabolism disorders.
For the medicine for treating hyperlipemia, the western medicines mostly adopt statins, such as atorvastatin, simvastatin, rosuvastatin and the like; the traditional Chinese medicine compound has more varieties, different composing ideas, and mainly comprises the medicines for promoting blood circulation and removing blood stasis, and is supplemented with the medicines with the efficacies of clearing liver and improving vision, tonifying liver and kidney, descending turbidity and eliminating dampness, clearing heat and resolving masses and the like. For example, CN200810157509.1 discloses a Chinese medicine for treating hyperlipidemia, which is specifically prepared from processed rhizoma cyperi, radix aucklandiae, radix linderae, orange peel, pericarpium citri reticulatae viride, fructus aurantii immaturus, cortex magnoliae officinalis, fructus amomi, rhizoma nardostachyos, citron peel, radix salviae miltiorrhizae, ligusticum wallichii, peach kernel, safflower, herba lycopi, radix curcumae, rhizoma curcumae longae, rhizoma corydalis, trogopterus dung, frankincense, myrrh, lignum dalbergiae odoriferae, radix astragali, rhizoma atractylodis macrocephalae, rhizoma polygonati, cotton root, bidens tripartita, hawthorn, medicated leaven, malt, rice. For another example, CN201310691315.0 discloses a Chinese medicinal composition for treating hyperlipidemia, which is prepared from the following raw materials in parts by weight: 10-15 parts of salvia miltiorrhiza, 15-20 parts of turmeric, 12-18 parts of bighead atractylodes rhizome, 16-22 parts of poria cocos, 10-15 parts of eucommia ulmoides, 5-10 parts of wild jujube leaves, 12-18 parts of scutellaria baicalensis, 15-20 parts of curcuma aromatica, 10-15 parts of rhizoma cyperi, 5-10 parts of radix scrophulariae, 10-15 parts of loranthus parasiticus, 8-14 parts of Chinese wampee leaves, 5-10 parts of rhizoma alismatis, 6-12 parts of semen cassiae, 10-15 parts of astragalus membranaceus, 5-10 parts of coix seeds, 10-15 parts of yellow lotus flowers, 8-14 parts of fructus psoraleae, 10-15 parts of Chinese yams, 12-18 parts of rhizoma atractylodis, 15-20 parts of potentilla discolor, 6-12 parts of polygonum multiflorum. The medicines have many ingredients, complicated administration, unclear main lines and large prescription amount.
In another idea, for example, CN201510013731.4 discloses a traditional Chinese medicine health product for assisting in reducing blood lipid, angelica sinensis and astragalus membranaceus lipid-lowering particles, which adopts five medicines with blood lipid-lowering efficacy, including, by weight, 8-12 parts of angelica sinensis, 12-18 parts of astragalus membranaceus, 12-18 parts of radix puerariae, 8-12 parts of rhizoma alismatis, and 10-15 parts of hawthorn. The formulation idea of the patent document is to throw away the principle of traditional Chinese medicine formulation and directly combine a plurality of medicines with the function of reducing blood fat together for formulation.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition with the effect of treating hyperlipidemia.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition.
The invention also aims to provide a traditional Chinese medicine preparation with the effect of treating hyperlipemia.
The invention also aims to provide application of the traditional Chinese medicine composition.
The purpose of the invention is realized by the following technical scheme.
A traditional Chinese medicine composition with a function of treating hyperlipidemia is prepared from the following raw material medicines in parts by weight:
3-8 parts of ginseng, 8-18 parts of turmeric, 6-14 parts of bighead atractylodes rhizome, 6-14 parts of dried orange peel, 6-14 parts of cattail pollen, 5-12 parts of lotus leaf, 5-12 parts of rhizoma alismatis, 5-12 parts of kelp, 5-12 parts of cassia seed and 5-12 parts of hawthorn.
According to a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
3-6 parts of ginseng, 10-16 parts of turmeric, 8-12 parts of bighead atractylodes rhizome, 8-12 parts of dried orange peel, 8-12 parts of cattail pollen, 6-10 parts of lotus leaf, 6-10 parts of rhizoma alismatis, 6-10 parts of kelp, 6-10 parts of cassia seed and 6-10 parts of hawthorn.
According to a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight:
6 parts of ginseng, 15 parts of turmeric, 12 parts of bighead atractylodes rhizome, 12 parts of dried orange peel, 12 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 6 parts of cassia seed and 6 parts of hawthorn; or
8 parts of ginseng, 16 parts of turmeric, 12 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 8 parts of cassia seed and 5 parts of hawthorn; or
3 parts of ginseng, 10 parts of turmeric, 10 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 10 parts of lotus leaf, 10 parts of rhizoma alismatis, 10 parts of kelp, 10 parts of cassia seed and 10 parts of hawthorn.
In the present invention, preferably, the white atractylodes rhizome is bran-fried white atractylodes rhizome.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) extracting Curcuma rhizome, Ginseng radix and pericarpium Citri Tangerinae with ethanol water solution to obtain ethanol extract and residue;
(2) mixing the residues with Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, and extracting with water and precipitating with ethanol to obtain mixed extract;
(3) and mixing the alcohol extract and the mixed extract to obtain the traditional Chinese medicine composition.
According to a preferred embodiment of the present invention, the preparation method of the Chinese medicinal composition comprises the following steps:
(1) extracting turmeric with a first aqueous ethanol solution to obtain turmeric alcohol extract and turmeric dregs; extracting ginseng and pericarpium citri reticulatae with a second ethanol aqueous solution to obtain ginseng pericarpium citri reticulatae alcohol extract and ginseng pericarpium citri reticulatae dregs;
wherein the concentration of the first ethanol aqueous solution is 60-90%, and the Curcuma rhizome is extracted by heating reflux extraction, ultrasonic extraction or cold soaking for 1-4 times; the second ethanol concentration is 60-90%, and the extraction method of Ginseng radix and pericarpium Citri Tangerinae is selected from heating reflux extraction, ultrasonic extraction or cold soaking for 1-4 times;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, and extracting with water and precipitating with ethanol to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
In the present invention, preferably, the extraction method in step (2) is: mixing turmeric dregs, ginseng and tangerine peel dregs, bighead atractylodes rhizome, cattail pollen, lotus leaves, rhizoma alismatis, kelp, cassia seeds and hawthorn, extracting with water to obtain a water extracting solution, concentrating the water extracting solution until the relative density is 1.05-1.10 at the temperature of 60 ℃, then adding an ethanol water solution until the ethanol concentration is 50-70%, precipitating, filtering, and concentrating the filtrate to obtain the mixed extract.
According to one embodiment of the present invention, the preparation method comprises the steps of:
(1) extracting Curcuma rhizome with 80% ethanol water solution cold soaking method for 2 times, each time for 8 hr, the amount of ethanol water solution is 8 times of Curcuma rhizome weight, to obtain Curcuma rhizome ethanol extractive solution and Curcuma rhizome residue; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract; extracting Ginseng radix and pericarpium Citri Tangerinae with 70% ethanol water solution under heating and refluxing for 3 times, wherein the amount of ethanol water solution is 12 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time, and the extraction time is 1 hr each time to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; concentrating the ginseng and dried orange peel alcohol extract to obtain a ginseng and dried orange peel alcohol extract;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, extracting with water for 2 times, each time adding water 14 times of the total weight of the medicinal materials, each time extracting for 1.5 hr to obtain water extractive solution; concentrating the water extractive solution to relative density of 1.05-1.10 at 60 deg.C, adding ethanol water solution to ethanol concentration of 60%, precipitating, filtering, and concentrating the filtrate to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
The invention also provides a traditional Chinese medicine preparation which comprises the traditional Chinese medicine composition.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine with an effect of treating hyperlipidemia.
The traditional Chinese medicine composition disclosed by the invention is novel in formula thought, accurate in medicine application and reasonable in compatibility, three medicines of ginseng, dried tangerine peel and bighead atractylodes rhizome which can tonify qi and invigorate spleen are reused, and the effect of promoting blood circulation and removing blood stasis is enhanced, so that the purpose of promoting blood circulation by qi circulation is realized, the blood circulation is smooth, the blood stasis is eliminated, and the effect of treating hyperlipidemia is exact.
Detailed Description
The present invention will be further described with reference to the following specific examples, but the scope of the present invention is not limited thereto.
< Chinese medicinal composition >
The traditional Chinese medicine composition with the effect of treating hyperlipemia is prepared from the following raw material medicines in parts by weight: 3-8 parts of ginseng, 8-18 parts of turmeric, 6-14 parts of bighead atractylodes rhizome, 6-14 parts of dried orange peel, 6-14 parts of cattail pollen, 5-12 parts of lotus leaf, 5-12 parts of rhizoma alismatis, 5-12 parts of kelp, 5-12 parts of cassia seed and 5-12 parts of hawthorn.
In the invention, preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-6 parts of ginseng, 10-16 parts of turmeric, 8-12 parts of bighead atractylodes rhizome, 8-12 parts of dried orange peel, 8-12 parts of cattail pollen, 6-10 parts of lotus leaf, 6-10 parts of rhizoma alismatis, 6-10 parts of kelp, 6-10 parts of cassia seed and 6-10 parts of hawthorn.
According to a preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6 parts of ginseng, 15 parts of turmeric, 12 parts of bighead atractylodes rhizome, 12 parts of dried orange peel, 12 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 6 parts of cassia seed and 6 parts of hawthorn.
According to another preferred embodiment of the invention, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 8 parts of ginseng, 16 parts of turmeric, 12 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 8 parts of cassia seed and 5 parts of hawthorn.
According to another preferred embodiment of the present invention, the Chinese medicinal composition is prepared from the following raw material medicines in parts by weight: 3 parts of ginseng, 10 parts of turmeric, 10 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 10 parts of lotus leaf, 10 parts of rhizoma alismatis, 10 parts of kelp, 10 parts of cassia seed and 10 parts of hawthorn.
In the invention, the white atractylodes rhizome is preferably bran-fried white atractylodes rhizome, so that the medicine property is mild, and the spleen-tonifying and flatulence-relieving functions are better, thereby enhancing the effect of tonifying spleen and qi of the whole composition.
The traditional Chinese medicine composition can be prepared by a conventional water decoction method, and can also be prepared by other preparation methods without special limitation.
The traditional Chinese medicine composition takes ginseng as a monarch drug, takes the effects of invigorating primordial qi and tonifying spleen and lung, takes dried orange peel and bighead atractylodes rhizome as ministerial drugs, and takes the effects of regulating qi and strengthening spleen and invigorating qi by using dried orange peel; the bran-fried bighead atractylodes rhizome has better effects of tonifying spleen and replenishing qi. The monarch drug and the ministerial drug, namely the dried orange peel and the bran-fried bighead atractylodes rhizome are used together, so that the spleen strengthening and qi benefiting effects are outstanding. The turmeric is adopted to strongly break blood stasis and promote qi circulation, the cattail pollen is adopted to strengthen the blood circulation-promoting and blood stasis-removing effects of the turmeric, and the hawthorn is matched with the functions of promoting blood circulation and removing blood stasis and removing meat stagnation, so that the three have the functions of regulating qi and promoting blood circulation, the qi circulation promotes blood circulation, the blood circulation is smooth, and the blood stasis is eliminated, thereby being the medicine for treating the symptoms; the three ingredients are matched with ginseng and bighead atractylodes rhizome, and can take effect on both principal and secondary aspects and eliminate pathogenic factors without damaging vital qi. In addition, the cassia seed has the functions of relaxing bowel, the rhizoma alismatis, the kelp and the lotus leaf have the functions of inducing diuresis and reducing edema, and the four medicines are matched to discharge metabolic wastes in vivo from stool and urine so as to provide a way for pathogens to be used as adjuvant and guiding medicines together. The composition disclosed by the invention is accurate in medicine, precise and appropriate in compatibility, and the ginseng, the dried orange peel and the bighead atractylodes rhizome which can tonify qi and invigorate spleen are reused, so that the effect of promoting blood circulation and removing blood stasis is enhanced, the purpose of promoting blood circulation by qi circulation is realized, the blood circulation is smooth, and blood stasis is eliminated, so that the purpose of effectively treating hyperlipidemia is achieved. The traditional Chinese medicine composition has very remarkable effect of treating hyperlipidemia (including hypercholesterolemia and hypertriglyceridemia) through clinical medication (water decoction) of patients.
< preparation method >
The Chinese medicinal composition can be prepared by adopting a conventional water extraction method, such as a water decoction method, a heating reflux extraction method, an ultrasonic extraction method and the like.
According to one embodiment of the present invention, the preparation method comprises the steps of:
(1) extracting Curcuma rhizome, Ginseng radix and pericarpium Citri Tangerinae with ethanol water solution to obtain ethanol extract and residue;
(2) mixing the residues with Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, and extracting with water and precipitating with ethanol to obtain mixed extract;
(3) and mixing the alcohol extract and the mixed extract to obtain the traditional Chinese medicine composition.
In the step (1), the turmeric, ginseng and dried orange peel may be extracted respectively, or may be extracted after being mixed in any way.
In the step (1), preferably, turmeric is separately extracted, and ginseng and dried orange peel are mixed and then extracted. The aqueous ethanol solution from which the turmeric is extracted is referred to as a first aqueous ethanol solution, and its concentration may be 60 to 90%, preferably 70 to 80%, more preferably 80%. The method for extracting Curcuma rhizome may be heating reflux extraction, ultrasonic extraction or cold soaking method, preferably cold soaking method. According to a preferred embodiment, the turmeric is extracted by a cold soaking method of 60-90%, preferably 80% ethanol water solution for 1-3 times, preferably 2 times, each time for 5-10 hours, preferably 8 hours, the dosage of the first ethanol water solution is 6-10 times, preferably 8 times of the weight of the turmeric, so as to obtain turmeric alcohol extract and turmeric dregs; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract.
In a preferred embodiment, the aqueous ethanol solution from which the ginseng and the dried orange peel are extracted is referred to as a second aqueous ethanol solution, and the concentration thereof may be 60 to 90%, preferably 70 to 80%, and more preferably 70%. The method for extracting Ginseng radix and pericarpium Citri Tangerinae may be heating reflux extraction, ultrasonic extraction or cold soaking, preferably heating reflux extraction. According to a preferred embodiment, the ginseng and the dried orange peel are heated and refluxed for 1 to 4 times, preferably 2 to 3 times, more preferably 3 times by using 60 to 90%, preferably 70 to 80%, more preferably 70% ethanol water solution; the dosage of the second ethanol water solution is 6-16 times, preferably 8-14 times, and more preferably 14 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time; extracting for 0.5-2 hr, preferably 1-2 hr, more preferably 1.5 hr to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; and concentrating the ginseng and dried orange peel alcohol extract to obtain the ginseng and dried orange peel alcohol extract.
The turmeric alcohol extract and ginseng tangerine peel alcohol extract obtained by the extraction method in the step (1) are more beneficial to the composition to play a role of reducing blood fat and reducing the dosage of medicines.
In the step (2), the ethanol aqueous solution used for alcohol precipitation is called a third ethanol aqueous solution. In the step, turmeric dregs, ginseng and tangerine peel dregs, largehead atractylodes rhizome, cattail pollen, lotus leaf, rhizoma alismatis, kelp, cassia seed and hawthorn are mixed, water extraction is carried out to obtain water extraction liquid, the water extraction liquid is concentrated to the relative density of 1.05-1.10 at the temperature of 60 ℃, then a third ethanol water solution is added to the water extraction liquid until the ethanol concentration is 50-70 percent, preferably 60 percent, precipitation, filtration and concentration of filtrate are carried out to obtain the mixed extract. The water extraction method can be selected from water decoction method or heating reflux extraction method, and is preferably heating reflux extraction method. The number of water extractions may be 1 to 4, preferably 2 to 3, more preferably 2; the water amount added each time is 8-18 times of the total weight of the medicinal materials, preferably 10-16 times, and more preferably 14 times; the extraction time is 0.5-2 hours, preferably 1-1.5 hours, and more preferably 1.5 hours. The total weight of the medicinal materials is the total weight of all 10 medicinal materials such as turmeric. The concentration of the third aqueous ethanol solution is not particularly limited, and an aqueous ethanol solution of 90% or more is preferable.
The mixed extract obtained by the extraction method in the step (2) is more beneficial to the composition to play a role of reducing blood fat, and can effectively remove components which do not contribute to the function of reducing blood fat and reduce the dosage of the medicine.
And (3) mixing the turmeric alcohol extract, the ginseng and dried orange peel alcohol extract and the mixed extract to obtain the traditional Chinese medicine composition. The step (3) may also include a step of drying after mixing the turmeric alcohol extract, ginseng tangerine peel alcohol extract and mixed extract, and the drying method may adopt a conventional method in the fields of reduced pressure drying, spray drying and the like, and is not described again.
According to one embodiment of the present invention, the preparation method comprises the steps of:
(1) extracting Curcuma rhizome with 60-90% ethanol water solution by cold soaking for 5-10 hr for 1-3 times to obtain Curcuma rhizome ethanol extractive solution and Curcuma rhizome residue, wherein the amount of ethanol water solution is 6-10 times of weight of Curcuma rhizome; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract; extracting Ginseng radix and pericarpium Citri Tangerinae with 60-90% ethanol water solution under heating and refluxing for 1-4 times, wherein the extraction time is 0.5-2 hr each time, and the amount of ethanol water solution is 6-16 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; concentrating the ginseng and dried orange peel alcohol extract to obtain a ginseng and dried orange peel alcohol extract;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, extracting with water for 1-4 times, each time adding water 8-18 times of the total weight of the medicinal materials, each time extracting for 0.5-2 hr to obtain water extractive solution; concentrating the water extractive solution to relative density of 1.05-1.10 at 60 deg.C, adding third ethanol aqueous solution to ethanol concentration of 50-70%, precipitating, filtering, and concentrating the filtrate to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
According to a preferred embodiment of the present invention, the preparation method comprises the steps of:
(1) extracting Curcuma rhizome with 80% ethanol water solution cold soaking method for 2 times, each time for 8 hr, the amount of ethanol water solution is 8 times of Curcuma rhizome weight, to obtain Curcuma rhizome ethanol extractive solution and Curcuma rhizome residue; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract; extracting Ginseng radix and pericarpium Citri Tangerinae with 70% ethanol water solution under heating and refluxing for 3 times, wherein the amount of ethanol water solution is 12 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time, and the extraction time is 1 hr each time to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; concentrating the ginseng and dried orange peel alcohol extract to obtain a ginseng and dried orange peel alcohol extract;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, extracting with water for 2 times, each time adding water 14 times of the total weight of the medicinal materials, each time extracting for 1.5 hr to obtain water extractive solution; concentrating the water extractive solution to relative density of 1.05-1.10 at 60 deg.C, adding ethanol water solution to ethanol concentration of 60%, precipitating, filtering, and concentrating the filtrate to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
The traditional Chinese medicine composition prepared by the optimal preparation method has better effect of reducing blood fat, and the dosage of the traditional Chinese medicine composition is obviously lower than that of the traditional water decoction method, so that the traditional Chinese medicine composition is more easily accepted by patients.
< preparation and use >
The invention also provides a traditional Chinese medicine preparation which comprises the traditional Chinese medicine composition and can also comprise pharmaceutically acceptable auxiliary materials. The dosage form of the Chinese medicinal preparation of the present invention is not particularly limited, and may be any dosage form in the art, such as tablets, pills, granules, capsules, oral liquids, and the like.
The traditional Chinese medicine composition has an obvious effect of treating hyperlipidemia, has an obvious treatment effect on hypercholesterolemia and hypertriglyceridemia, particularly has an obvious effect on hypercholesterolemia, can effectively reduce total cholesterol and low-density lipoprotein, and can be used for preparing a medicine for treating hyperlipidemia.
The embodiments and technical effects of the present invention will be described in detail below by way of specific examples and experimental examples.
Example 1
Taking 6 parts of ginseng, 15 parts of turmeric, 12 parts of bighead atractylodes rhizome, 12 parts of dried orange peel, 12 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 6 parts of cassia seed and 6 parts of hawthorn fruit by weight, preparing a traditional Chinese medicine composition A according to the following method:
(1) extracting Curcuma rhizome with 80% ethanol water solution by cold soaking method for 2 times, wherein the amount of ethanol water solution is 8 times of Curcuma rhizome weight each time, and the extraction time is 8 hr each time to obtain Curcuma rhizome ethanol extractive solution and Curcuma rhizome residue; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract; extracting Ginseng radix and pericarpium Citri Tangerinae with 70% ethanol water solution under heating and refluxing for 3 times, wherein the amount of ethanol water solution is 12 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time, and the extraction time is 1 hr each time to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; concentrating the ginseng and dried orange peel alcohol extract to obtain a ginseng and dried orange peel alcohol extract;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, extracting with water for 2 times, each time adding water 14 times of the total weight of the medicinal materials, each time extracting for 1.5 hr to obtain water extractive solution; concentrating the water extractive solution to relative density of 1.05-1.10 at 60 deg.C, adding ethanol water solution to ethanol concentration of 60%, precipitating, filtering, and concentrating the filtrate to obtain mixed extract;
(3) mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract, and drying to obtain the traditional Chinese medicine composition.
Example 2
Taking 6 parts of ginseng, 15 parts of turmeric, 12 parts of bighead atractylodes rhizome, 12 parts of dried orange peel, 12 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 6 parts of cassia seed and 6 parts of hawthorn fruit by weight, heating and refluxing for 3 times by using water, wherein the water addition amount is 14 times of the total weight of the medicinal materials each time, and the extraction time is 1.5 hours each time to obtain a water extract; and concentrating and drying the water extract to obtain a traditional Chinese medicine composition B.
Example 3
According to the parts by weight, 8 parts of ginseng, 16 parts of turmeric, 12 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 8 parts of cassia seed and 5 parts of hawthorn are taken, and the traditional Chinese medicine composition C is prepared according to the preparation method of the embodiment 1.
Example 4
According to the parts by weight, 3 parts of ginseng, 10 parts of turmeric, 10 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 10 parts of lotus leaf, 10 parts of rhizoma alismatis, 10 parts of kelp, 10 parts of cassia seed and 10 parts of hawthorn fruit are prepared into the traditional Chinese medicine composition D according to the preparation method of the embodiment 1.
Experimental example 1
1. Animal model making and experiment method
The animals were male SD rats of SPF grade purchased from Biotech limited, Viton, Beijing, and weighing 150-170 g.
Animals were allowed to drink water freely at room temperature (23 + -2 deg.C) and molding was started 7 days after acclimatizing feeding. Feeding the blank rats with normal drinking water and basic feed; the molded rats normally drink water, and are fed with basal feed and simultaneously fed with high-fat emulsion for intragastric administration (the formula of the high-fat emulsion is 20 wt% of lard, 5 wt% of cholesterol, 5 wt% of yolk powder, 1 wt% of propylthiouracil, 6 wt% of tween-80 and 63 wt% of distilled water), wherein the intragastric administration dose is 10ml/Kg and is once a day. After 3 weeks, blood was collected from retrobulbar venous plexus of a blank rat and a model rat, and serum was collected by centrifugation to measure the serum total cholesterol level. The total cholesterol level of the model rat is obviously increased, and the model rat is obviously different from a blank rat (P <0.05), thus indicating that the model is successfully made.
Taking 50 successfully molded rats, randomly dividing the rats into 5 groups, namely a model group, a Lipitor positive medicine group, a high-dosage group, a medium-dosage group and a low-dosage group, wherein each group comprises 10 rats; another 10 blank rats without model were used as a blank control group. From the 4 th week, the blank control group and the model group are infused with normal saline, and the dosage is 10 ml/Kg; the traditional Chinese medicine composition D (the high dose, the medium dose and the low dose are respectively equal to the crude drug amount of 18g/Kg, 9g/Kg and 4.5g/Kg) of the invention in the embodiment 4 is respectively administrated by intragastric administration, and the lipitor suspension for the positive medicine is administrated by intragastric administration in the dose of 10mg/Kg, 1 time per day and continuously administrated for 4 weeks.
After the administration is finished, all rats are fasted for 12 hours without water prohibition, blood is taken from abdominal aorta after chloral hydrate anesthesia, and serum is taken by conventional centrifugation to detect Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) respectively.
2. Results of the experiment
The blood lipid changes of the rats in each group are shown in Table 1.
TABLE 1 blood lipid changes in rats of each group: (
n＝10)
Note: p <0.05 compared to model group; comparison with model group # P < 0.01.
Compared with the blank control group, the model group rats have increased TC and LDL-C levels, and the difference has statistical significance (P is less than 0.05). Compared with the model group, the TC and LDL-C levels of rats in the positive control group and rats in the low-dose group are reduced, and the difference has statistical significance (P is less than 0.01 or P is less than 0.05), which indicates that the composition has obvious lipid-lowering effect.
The present invention is not limited to the above-described embodiments, and any variations, modifications, and substitutions which may occur to those skilled in the art may be made without departing from the spirit of the invention.
Claims (10)
1. The traditional Chinese medicine composition with the effect of treating hyperlipemia is characterized by being prepared from the following raw material medicines in parts by weight:
3-8 parts of ginseng, 8-18 parts of turmeric, 6-14 parts of bighead atractylodes rhizome, 6-14 parts of dried orange peel, 6-14 parts of cattail pollen, 5-12 parts of lotus leaf, 5-12 parts of rhizoma alismatis, 5-12 parts of kelp, 5-12 parts of cassia seed and 5-12 parts of hawthorn.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:
3-6 parts of ginseng, 10-16 parts of turmeric, 8-12 parts of bighead atractylodes rhizome, 8-12 parts of dried orange peel, 8-12 parts of cattail pollen, 6-10 parts of lotus leaf, 6-10 parts of rhizoma alismatis, 6-10 parts of kelp, 6-10 parts of cassia seed and 6-10 parts of hawthorn.
3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:
6 parts of ginseng, 15 parts of turmeric, 12 parts of bighead atractylodes rhizome, 12 parts of dried orange peel, 12 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 6 parts of cassia seed and 6 parts of hawthorn; or
8 parts of ginseng, 16 parts of turmeric, 12 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 8 parts of lotus leaf, 8 parts of rhizoma alismatis, 8 parts of kelp, 8 parts of cassia seed and 5 parts of hawthorn; or
3 parts of ginseng, 10 parts of turmeric, 10 parts of bighead atractylodes rhizome, 10 parts of dried orange peel, 10 parts of cattail pollen, 10 parts of lotus leaf, 10 parts of rhizoma alismatis, 10 parts of kelp, 10 parts of cassia seed and 10 parts of hawthorn.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Atractylodis rhizoma is bran-parched Atractylodis rhizoma.
5. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4, wherein the method comprises the following steps:
(1) extracting Curcuma rhizome, Ginseng radix and pericarpium Citri Tangerinae with ethanol water solution to obtain ethanol extract and residue;
(2) mixing the residues with Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, and extracting with water and precipitating with ethanol to obtain mixed extract;
(3) and uniformly mixing the alcohol extract and the mixed extract to obtain the traditional Chinese medicine composition.
6. The method for preparing a Chinese medicinal composition according to any one of claims 1 to 4, wherein the method comprises the following steps:
(1) extracting turmeric with a first aqueous ethanol solution to obtain turmeric alcohol extract and turmeric dregs; extracting ginseng and pericarpium citri reticulatae with a second ethanol aqueous solution to obtain ginseng pericarpium citri reticulatae alcohol extract and ginseng pericarpium citri reticulatae dregs;
wherein the concentration of the first ethanol aqueous solution is 60-90%, and the Curcuma rhizome is extracted by heating reflux extraction, ultrasonic extraction or cold soaking for 1-4 times; the second ethanol concentration is 60-90%, and the extraction method of Ginseng radix and pericarpium Citri Tangerinae is selected from heating reflux extraction, ultrasonic extraction or cold soaking for 1-4 times;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, and extracting with water and precipitating with ethanol to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
7. The method according to claim 6, wherein the extraction method of step (2) is: mixing turmeric dregs, ginseng and tangerine peel dregs, bighead atractylodes rhizome, cattail pollen, lotus leaves, rhizoma alismatis, kelp, cassia seeds and hawthorn, extracting with water to obtain a water extracting solution, concentrating the water extracting solution until the relative density is 1.05-1.10 at the temperature of 60 ℃, then adding an ethanol water solution until the ethanol concentration is 50-70%, precipitating, filtering, and concentrating the filtrate to obtain the mixed extract.
8. The method of claim 6, comprising the steps of:
(1) extracting Curcuma rhizome with 80% ethanol water solution cold soaking method for 2 times, each time for 8 hr, the amount of ethanol water solution is 8 times of Curcuma rhizome weight, to obtain Curcuma rhizome ethanol extractive solution and Curcuma rhizome residue; concentrating the turmeric alcohol extract to obtain turmeric alcohol extract; extracting Ginseng radix and pericarpium Citri Tangerinae with 70% ethanol water solution under heating and refluxing for 3 times, wherein the amount of ethanol water solution is 12 times of the total weight of Ginseng radix and pericarpium Citri Tangerinae each time, and the extraction time is 1 hr each time to obtain Ginseng radix pericarpium Citri Tangerinae ethanol extractive solution and Ginseng radix pericarpium Citri Tangerinae residue; concentrating the ginseng and dried orange peel alcohol extract to obtain a ginseng and dried orange peel alcohol extract;
(2) mixing Curcuma rhizome residue, Ginseng radix pericarpium Citri Tangerinae residue, Atractylodis rhizoma, pollen Typhae, folium Nelumbinis, Alismatis rhizoma, thallus laminariae, semen Cassiae and fructus crataegi, extracting with water for 2 times, each time adding water 14 times of the total weight of the medicinal materials, each time extracting for 1.5 hr to obtain water extractive solution; concentrating the water extractive solution to relative density of 1.05-1.10 at 60 deg.C, adding ethanol water solution to ethanol concentration of 60%, precipitating, filtering, and concentrating the filtrate to obtain mixed extract;
(3) and mixing the turmeric alcohol extract, ginseng dried orange peel alcohol extract and mixed extract to obtain the traditional Chinese medicine composition.
9. A Chinese medicinal preparation having an effect of treating hyperlipidemia, which comprises the Chinese medicinal composition according to any one of claims 1 to 4.
10. Use of the Chinese medicinal composition according to any one of claims 1 to 4 for the preparation of a medicament having an effect of treating hyperlipidemia.
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