CN100998782B

CN100998782B - Traditional Chinese medicine oral liquid for treating gastrointestinal disease and its preparing method

Info

Publication number: CN100998782B
Application number: CN2006100111777A
Authority: CN
Inventors: 李祖泽; 施少斌; 郑荣波; 沈军; 黄晓丹
Original assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Current assignee: WANGLAOJI PHARMACEUTICAL CO Ltd GUANGZHOU CITY
Priority date: 2006-01-12
Filing date: 2006-01-12
Publication date: 2011-04-20
Anticipated expiration: 2026-01-12
Also published as: CN100998782A

Abstract

A Chinese medicine in the form of oral liquid for treating gastrointestinal disease is prepared from 16 Chinese-medicinal materials including uncaria stem with hooks, magnolia bark, trichosanthes root, tuckahoe, etc. Its preparing process is also disclosed.

Description

A kind of Chinese medicine oral liquid for the treatment of gastrointestinal disease and preparation method thereof

Technical field

The present invention relates to field of medicaments, particularly relate to a kind of Chinese medicine oral liquid for the treatment of gastrointestinal disease and preparation method thereof.

Background technology

Stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset, dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache are clinical common symptoms, and these symptoms can cause by multiple reason, and the double sense wind and cold of regarding sb. as an outsider of gastrointestinal disease is one of the main reasons wherein.In Song dynasty " formulary of peaceful benevolent dispensary " these symptoms are put down in writing to some extent, and the prescription of ageratum side as treatment is provided.Ageratum side is described as " heat-damp in summer panacea " by ancient Chinese medicine doctor.This side have induce sweat, damp eliminating and in effect, be usually used in treating the treatment of affection of exogenous wind-cold, internal injury humidity hysteresis, stomachache vomiting and diarrhoea clinically, mainly be with stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, fever and headache etc. are clinical manifestation, also are widely used at present the treatments such as common cold of gastrointestinal type, acute chronic enteritis of modern medicine.Health pill is the novel formulation that develops on the basis of the former technology of the positive invigorating oral liquid of traditional Radix agastaches, and China's " pharmacopeia " includes it wherein already.Health pill have induce sweat, damp eliminating and in function; Be mainly used in stomachache, diarrhoea, the food acid eructation of choking, nausea and vomiting, gastrointestinal upset: dyspepsia, the dizzy wave of journey, pestilent cold, the treatment of fever and headache.The Health pill of putting down in writing in the pharmacopeia adopts the method for making of " each pulverizing medicinal materials, general ball, coating ", thereby causes Health pill to exist the medicine active ingredient, reduces at gastrointestinal dissolution rate and absorbance, and soak time prolongs, and onset is slow.

Oral liquid is a kind of common dosage form, and the form characteristics of this kind preparation are: 1. drug effect is rapid, absorbs fast.2. it is convenient to use, and taking dose is few than the decoction amount, and can add correctives, and mouthfeel is good.3. carry, preservation, taking convenience.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of gastrointestinal disease.

Another object of the present invention provides a kind of preparation method for the treatment of the Chinese medicine oral liquid of gastrointestinal disease.

Pharmaceutical composition of the present invention is to be made by the effective site of extracting in Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, the Semen Coicis.

The consumption of each component of pharmaceutical composition of the present invention and proportioning obtain with Test Summary by groping in a large number through the inventor, and each component raw material medicine all has curative effect preferably at the following weight parts ratio range: 15.50～55.80 parts of Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss.

Preferred each component raw material medicine of pharmaceutical composition of the present invention all has curative effect preferably at the following weight parts ratio range: 27.17～41.20 parts of Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, (81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss.

Best each component raw material medicine of pharmaceutical composition of the present invention has curative effect preferably in the following weight parts proportioning: 34.10 parts of Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss.

Medicine of the present invention can be made any preparation on the pharmaceutics; Preferably make tablet, sugar coated tablet, film coated tablet, enteric coated tablet, suck agent, oral liquid, granule, soft capsule, capsule, electuary, pill, powder, unguentum.

The preparation of the effective ingredient of the described present composition and preparation can adopt following method: one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract to raw material, make pill, oral liquid, tablet, granule, capsule, soft capsule, but this can not limit protection scope of the present invention.

The oral liquor one of Chinese medicine composition of the present invention:

The oral liquor one of Chinese medicine composition of the present invention comprises the steps:

A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis;

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 0.5～2 times of water logging bubble after 0.5～2 hour, adopted vapor distillation 1～3 hour, collect volatile oil device preservation in addition; Medicinal residues decoct with water 1～3 time, add 1000～3000L water at every turn, decoct collecting decoction 1～2 hour, filter, filtrate is concentrated into relative density 1.04～1.20 in the time of 45 ℃～75 ℃, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%～55%, left standstill 4～36 hours, and filtered, reclaim ethanol; Be concentrated into relative density 1.25～1.45 in the time of 45 ℃～75 ℃, get extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water 1～3 time, add 1000～3000L decocting at every turn and boiled 1～3 hour, collecting decoction filters, filtrate is concentrated into relative density 1.02～1.05 in the time of 45 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 30～50%, left standstill 4～36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 45 ℃～75 ℃, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water 1～3 time, the each decoction 0.5～2 hour, add 1000～3000L water, collecting decoction filters at every turn, filtrate is concentrated into relative density 1.02～1.05 in the time of 45 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 35～55%, left standstill 4～36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 45 ℃～75 ℃, get extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water 1～3 time, add 1000～3000L decocting at every turn and boiled 0.5～3 hour, collecting decoction filters, filtrate is concentrated to relative density 1.01～1.15 in the time of 45 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 50%～70%, left standstill 4～36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.02～1.20 in the time of 45 ℃～75 ℃, get extractum four, standby;

C. the preparation of fragrant solution: earlier required Tween-80 is placed in the beaker, adds volatile oil then, be stirred to mix homogeneously, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to 25～100L, stir, filter; Again sucrose is joined in the filtered solution, thin up to 100～300L, stirring makes dissolving, heated and boiled 0.2～1 hour, filter, in filtered solution, add water to 300～1000L, stir, put cold, to below 60 ℃, filter, add deployed Aromatic water solution, stir, add water to 300～1000L; Embedding, gland, 115～135 ℃ of pressure sterilizings 10～30 minutes, packing promptly gets the oral liquid finished product.

The oral liquor one of preferred invention Chinese medicine composition comprises the steps:

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 1 times of water logging bubble after 1 hour, adopted vapor distillation 2 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water secondary, add 1500L water at every turn, decoct 1.5 hours, and collecting decoction filters, and filtrate is concentrated into relative density 1.08～1.12 in the time of 55 ℃～60 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, leave standstill 8～16 hours, filter, and reclaim ethanol; Be concentrated into relative density 1.25～1.30 in the time of 55 ℃～60 ℃, get extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water secondary, add the 2000L decocting for the first time and boiled 2 hours, add the 1500L decocting for the second time and boiled 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～60 ℃, puts cold, adding ethanol makes and contains the alcohol amount and reach 40%, left standstill 8～16 hours, and filtered, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～60 ℃, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water secondary, the each decoction 1 hour adds 2000L water for the first time, adds 1500L water for the second time, collecting decoction, filter, filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～60 ℃, puts cold, adding ethanol makes and contains the alcohol amount and reach 45%, left standstill 8～16 hours, and filtered, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～60 ℃, get extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water secondary, add the 2000L decocting for the first time and boiled 2 hours, add the 1500L decocting for the second time and boiled 1 hour, collecting decoction, filter, filtrate is concentrated to relative density 1.02～1.05 in the time of 55 ℃～60 ℃, puts cold, adding ethanol makes and contains the alcohol amount and reach 60%, left standstill 8～16 hours, and filtered, reclaim ethanol; Be concentrated into 55 ℃～60 ℃ timing relative densities 1.05～1.10, get extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 50L, stir, filter; Sucrose is joined in the filtered solution, thin up is to 200L again, and stirring makes dissolving, and heated and boiled 0.5 hour is filtered; In filtered solution, add water to 600L, stir, put coldly,, filter, add deployed Aromatic water solution, stir, add water to 600L to below 60 ℃; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes, packing promptly gets the oral liquid finished product.

The oral liquor two of Chinese medicine composition of the present invention:

The oral liquor two of Chinese medicine composition of the present invention comprises the steps:

A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis; More than 16 flavor medical materials, decoct with water 1～3 time, decocted 0.5～4 hour at every turn, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.20 in the time of 45 ℃～70 ℃, puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 10%～90%, left standstill 1～36 hour, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.01～1.25 in the time of 45 ℃～70 ℃, it is standby to get extractum;

B. the preparation of fragrant solution: earlier required Tween-80 is placed in the vessel, adds the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis volatile oil then, be stirred to mix homogeneously, standby;

C. oral liquid preparation: get extractum, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.2～2 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, add deployed fragrant solution, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 10～60 minutes; Packing promptly gets the oral liquid finished product.

The oral liquor two of preferred Chinese medicine composition of the present invention comprises the steps:

A. it is standby to get recipe quantity Ramulus Uncariae Cum Uncis, Cortex Magnoliae Officinalis, Radix Trichosanthis, Poria, the Radix Angelicae Dahuricae, Guangdong Massa Medicata Fermentata, Fructus Tribuli, Rhizoma Atractylodis, Radix Puerariae, Exocarpium Citri Grandis, Fructus Oryzae Germinatus, Flos Chrysanthemi, the Radix Aucklandiae, Herba Pogostemonis, Herba Menthae, Semen Coicis; More than 16 flavor medical materials, decoct with water secondary, decocted 1～3 hour for the first time, decocting boiled 1～2 hour for the second time, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.11 in the time of 55 ℃～60 ℃, puts cold; Precipitate with ethanol, reclaim ethanol, add ethanol and make and contain the alcohol amount and reach 20%～80%, left standstill 4～24 hours, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.02～1.15 in the time of 55 ℃～60 ℃, it is standby to get extractum;

C. oral liquid preparation: get extractum, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, add deployed fragrant solution, it is standby to stir; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

The oral liquor three of Chinese medicine composition of the present invention:

The oral liquor three of Chinese medicine composition of the present invention comprises the steps:

A. the hook taking rattan is 15.50～55.80 parts, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1～4 time, and each 0.2～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1～4 time, and each 0.2～3 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 30～65%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1～4 time, and each 0.2～1.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～4 time, and each 0.2～3 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1～4 time with 50～85% alcohol heating reflux respectively, and each 0.5～3.5 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1～4 time with 50～85% alcohol heating reflux, and each 0.5～3.5 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 6～14% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 50～95 ℃ of oven dry, and is standby;

C. the preparation of fragrant solution: earlier required Tween-80 is placed in the vessel, adds Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhzoma Atractylodis Lanceae volatile oil then, be stirred to mix homogeneously, standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.2～2 hour is filtered, and adds water to requirement, stir, put coldly,, filter to below 60 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 10～60 minutes promptly get the oral liquid finished product.

The oral liquor three of preferred Chinese medicine composition of the present invention comprises the steps:

A. the hook taking rattan is 27.17～41.20 parts, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2～3 times, and each 0.5～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2～3 times, and each 0.5～2 hour, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 35～55%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2～3 times, and each 0.2～1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2～3 times, and each 0.5～2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2～3 times with 60～80% alcohol heating reflux respectively, and each 1～3 hour, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2～3 times with 60～80% alcohol heating reflux, and each 1～3 hour, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8～12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60～90 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.2～1 hour is filtered, and adds water to requirement, stir, put coldly,, filter to below 60 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 115～125 ℃ of pressure sterilizings 15～40 minutes promptly get the oral liquid finished product.

The oral liquor three of best Chinese medicine composition of the present invention comprises the steps:

A. 34.10 parts in hook taking rattan, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss are standby;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water secondary, and 1.5 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water secondary, and each 0.5 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water secondary respectively, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract secondary with 70% alcohol heating reflux respectively, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts secondary with 70% alcohol heating reflux, and 2 hours for the first time, 1.5 hours for the second time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 10% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, and is standby;

C. the preparation of fragrant solution: earlier required Tween-80 is placed in the vessel, adds the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis volatile oil then, be stirred to mix homogeneously, standby;

D. oral liquid preparation: get extractum, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, add deployed fragrant solution, it is standby to stir; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

The oral liquor four of Chinese medicine composition of the present invention

The oral liquor four of Chinese medicine composition of the present invention comprises the steps:

A. get 15.50～55.80 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1～3 time at 35～100 ℃ with 2～12 times of water gagings, and each 0.5～5 hour, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35～80 ℃; Medicinal residues after the extraction extract 1～3 time at 35～100 ℃ with 2～12 times of amount ethanol of 30～80%, and each 0.5～5 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;

C. qinghuo reagent I, clear paste II, volatile oil add the oral liquid dissolved above-mentioned volatile oil of aromatic commonly used, make oral liquid according to the conventional preparation method of oral liquid.

The oral liquor four of preferred Chinese medicine composition of the present invention comprises the steps:

A. get 27.17～41.20 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 109.12～163.68 parts of Cortex Magnoliae Officinalis, 81.80～123.17 parts of Radix Trichosanthis, 217.94～327.85 parts in Poria, 109.12～165.56 parts of the Radixs Angelicae Dahuricae, 109.12～165.56 parts of Guangdong Massa Medicata Fermentata, 27.17～41.20 parts of Fructus Tribulis, 109.12～163.68 parts of Rhizoma Atractylodis, 109.12～163.68 parts of Radix Puerariaes, 54.48～81.73 parts of Exocarpium Citri Grandises, 81.80～123.17 parts of Fructus Oryzae Germinatus, 54.48～81.73 parts of Flos Chrysanthemis, 109.12～163.68 parts of the Radix Aucklandiae, 109.12～163.6 parts of Herba Pogostemonis, 54.48～81.73 parts of Herba Menthaes, 136.77～206.10 parts of Semen Coiciss are standby;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 50～90 ℃ with 3～8 times of water gagings, and each 1～3 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50～70 ℃; Medicinal residues after the extraction extract 2～3 times at 40～80 ℃ with 3～8 times of amount ethanol of 40～70%, and each 1～3 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50～70 ℃;

C. qinghuo reagent I, clear paste II, mix homogeneously adds water, stir, filter, again sucrose is poured into wherein, thin up is to requirement, and stirring makes dissolving, heated and boiled 0.2～2 hour, be filtered to the medicinal liquid clarification, add water to requirement, stir, put coldly,, filter to below 60 ℃, add an amount of Tween-80 and dissolve the fragrant solution of above-mentioned volatile oil, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 10～60 minutes; Packing promptly gets the oral liquid finished product.

The oral liquor four of best Chinese medicine composition of the present invention comprises the steps:

A. it is standby to get 34.10 parts of crude drug proportioning Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;

B. active component preparation:

Get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;

C. qinghuo reagent I, clear paste II, mix homogeneously add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, add the fragrant solution that an amount of Tween-80 dissolves above-mentioned volatile oil, it is standby to stir; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Method five:

The oral liquor five of Chinese medicine composition of the present invention comprises the steps:

B. active component preparation:

Adding ethanol to clear paste I makes and contains alcohol amount and reach 50～80%, leave standstill, filter, filter to be concentrated into night and do not have the alcohol flavor, thin up to density is 1.01～1.15, rotating speed with 5000～20000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 1～5 times of column volume 1～3 time, 20%～80% ethanol elution of 2～8 times of column volumes of reuse 1～3 time, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～10 times distilled water eluting of first usefulness column volume 1～3 time, and water liquid discards, reuse 50～80% ethanol elutions 1～3 time, eluting ethanol is 2～10 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II adds the oral liquid dissolved above-mentioned volatile oil of aromatic commonly used, makes oral liquid according to the conventional preparation method of oral liquid.

The oral liquor five of preferred Chinese medicine composition of the present invention comprises the steps:

B. active component preparation:

Adding ethanol to clear paste I makes and contains alcohol amount and reach 60～70%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, thin up to density is 1.02～1.10, rotating speed with 10000～15000 rev/mins is centrifugal, and centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2～4 times of column volumes 2～3 times, 40～70% ethanol elution of 3～6 times of column volumes of reuse 2～3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2～8 times distilled water eluting of first usefulness column volume 2～3 times, and water liquid discards, reuse 60～70% ethanol elutions 2～3 times, eluting ethanol is 2～8 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. get dry extract I, dry extract II, mix homogeneously adds water, stir, filter, again sucrose is poured into wherein, thin up is to requirement, and stirring makes dissolving, heated and boiled 0.2～2 hour, be filtered to the medicinal liquid clarification, add water to requirement, stir, put coldly,, filter to below 60 ℃, add an amount of Tween-80 and dissolve the fragrant solution of above-mentioned volatile oil, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 10～60 minutes; Packing promptly gets the oral liquid finished product.

The oral liquor five of best Chinese medicine composition of the present invention comprises the steps:

B. active component preparation:

Add ethanol to clear paste I and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Add water to clear paste II that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. get dry extract I, dry extract II, mix homogeneously adds water, stir, filter, again sucrose is poured into wherein, thin up is to requirement, and stirring makes dissolving, heated and boiled 0.5 hour, be filtered to the medicinal liquid clarification, add water to requirement, stir, put coldly,, filter to below 60 ℃, add an amount of Tween-80 and dissolve the fragrant solution of above-mentioned volatile oil, it is standby to stir; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

In the process for preparing medicine five of the present invention, whether further purification of clear paste I made dry extract I; Clear paste II further purifies and makes dry extract II, determines according to the form of pharmaceutical preparation.In the process for preparing medicine five of the present invention, among among clear paste I, dry extract I, clear paste II, the dry extract II one or combination in any, dissolve the fragrant solution mix homogeneously of above-mentioned volatile oil with an amount of Tween-80, make oral liquid according to oral liquor.

The proportioning that above effective ingredient extracts raw materials used medicine can be any proportioning, and preferred feedstock medicine proportioning is a dosage range provided by the present invention.

More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.

The specific embodiment

In order to understand the present invention better, logical below test example is further set forth the beneficial effect of medicine of the present invention.By observing medicine of the present invention wind and cold is held under the arm wet hold under the arm the stagnate flu of card, the influence of acute gastroenteritis, the therapeutical effect of medicine of the present invention is described.Below used medicine for the ease of narration, below will be called for short medicine of the present invention according to the medicine that embodiment 7 obtains according to the preparation of embodiment 7 methods in the test.

Test example 1: Drug therapy flu of the present invention clinical research

One, qualified experimenter's selection

(1) Chinese medical discrimination standard: [working out] with reference to " new Chinese medicine clinical research guideline " and high Chinese medicine universities and colleges' teaching materials " Chinese Internal Medicine "

Wind and cold is held wet hold under the arm stagnant (flu) under the arm: nasal obstruction watery nasal discharge, cough, pharyngalgia, fever with aversion to cold, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, anorexia, or the belch acid regurgitation is arranged, stomachache is uncomfortable, stool is uncomfortable, light red tongue is fat or light red, tongue in vain, stringy and tense pulse or stringy and rolling pulse.

(2) Western medicine diagnose standard

Flu: [with reference to " practical internal medicine "]

1, the popular contact history of flu is arranged;

2, based on local symptom, General Symptoms can have or be not obvious;

Local symptom: sneeze, nasal obstruction, watery nasal discharge, cough sometimes, pharyngalgia, hoarseness, shed tears;

General Symptoms: fever with aversion to cold, general malaise, headache and dizzy, extremity aching pain in waist and back;

3, hemogram: how normal numeration of leukocyte is or on the low side.

Two, clinical implementation scheme

(1) test method: adopt the randomized controlled trial method

(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use

(3) usage and dosage

The treatment group: medicine of the present invention, oral, each 2 bottles, every day 3 times.

Matched group: HUOXIANGZHENGQI KOUFUYE, oral, each 2 bottles, every day 3 times.

(4) course of treatment: 3 days.

(5) observation index

The health giving quality observation item

Related symptoms and sign: as aversion to cold, heating, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.

Symptom scalar quantization table

Symptom	Do not have (0 grade)	Gently (I level)	In (II level)	Heavy (III level)
					Aversion to cold	Do not have (0 minute)	Aversion to cold need not add clothing (1 minute)	Aversion to cold need add clothing (2 minutes)	Aversion to cold need be thickeied clothing or quilt (3 minutes)
Heating	Do not have (0 minute)	37.1～37.9 ℃ of body temperature (1 minute)	38～38.5 ℃ of body temperature (2 minutes)	Body temperature is (3 minutes) more than 38.6 ℃
					Nasal obstruction	Do not have (0 minute)	The sense of obstruction is arranged, low voice speaking (1 minute)	Nose cold occur now and then (2 minutes)	Nasal obstruction constant (3 minutes)
Watery nasal discharge	Do not have (0 minute)	Idol has watery nasal discharge (1 minute)	The time watery nasal discharge (2 minutes) arranged	Continue watery nasal discharge (3 minutes)
					Cough	Do not have (0 minute)	Idol has (1 minute)	The time (2 minutes) arranged	Frequently (3 minutes)
Pharyngalgia	Do not have (0 minute)	Hypodynia (1 minute)	Pharyngalgia (2 minutes)	Pain is (3 minutes) very
					Dizziness headache	Do not have (0 minute)	Dizzy pain is light, the time end (1 minute) when doing	Heavier, continue more than (2 minutes)	Dizziness headache can not be adhered to work (3 minutes)
Limb aching pain	Do not have (0 minute)	Slightly ache (1 minute)	Ache obviously (2 minutes)	Ache and accompany joint stuffiness (3 minutes)
					Fullness in the epigastrium and chest	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes)	Distension continues the alleviation of need taking medicine (3 minutes) unbearably
The belch acid regurgitation	Do not have (0 minute)	Idol has belch acid regurgitation (1 minute)	The time belch acid regurgitation (2 minutes) arranged	Frequent belch acid regurgitation (3 minutes)

Nausea and vomiting	Do not have (0 minute)	Idol has nauseating (1 minute)	In the time, have nauseatingly, and idol has a vomiting (2 minutes)	Frequent nauseating, vomiting (3 minutes) sometimes
					Diet reduces	Do not have (0 minute)	Appetite reduces (1 minute)	Appetite reduces by 1/3 (2 minutes)	Appetite reduces by 1/2 (3 minutes)
Epigastric pain	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes)	Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably
					Loose stool	Do not have (0 minute)	It is shapeless to defecate, every day 1～3 time (1 minute)	Loose stool, every day 4～6 times (2 minutes)	The stool water sample, every day is (3 minutes) more than 7 times

Three, efficacy assessment standard

1, flu tcm syndrome curative effect determinate standard

(1) clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%.

(2) produce effects: clinical symptoms, sign are obviously improved, and the syndrome integration reduces 〉=70%

(3) effective: clinical symptoms, sign take a favorable turn, and the syndrome integration reduces 〉=30%

(4) invalid: clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.

Computational methods (nimodipine method):

Four, statistical procedures

Group data X ²Check, ranked data be with the relatively Wilcoxon rank test (corrections) of two samples, and two sample means are relatively with t check or Wilcoxon rank test, and rank test is relatively matched with paired t-test or Wilcoxon in self front and back.All statistical test all adopt two-sided test, and the P value is less than or equal to 0.05 difference that will be considered to be checked statistical significance.

The result

One, physical data

This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.Chinese medical discrimination is that wind and cold is held the wet card that stagnates of holding under the arm under the arm, and Western medicine diagnose is flu.All be the outpatient.

Two, comparability inspection before the treatment

1, two groups of preceding cardinal symptoms of treatment, sign total marks compare

State of an illness total mark comparison before the table 1 liang group treatment (x ± SD)

Cardinal symptom, sign total mark compare before two groups of treatments, and difference does not have significance.

2, the comparison of two groups of preceding symptoms of treatment

The comparison of symptoms such as heating before the table 2 liang group treatment, aversion to cold, sign

The comparisons of symptoms such as heating, aversion to cold, sign before two groups of treatments except that the order of severity treatment group of pharyngalgia is higher than matched group, have outside the significant difference, all the other there are no significant differences.

Comparability detects and shows before the above-mentioned treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.Show that two groups have comparability.

Three, efficacy analysis

1, total effects analysis

This research has qualified experimenter's 237 examples, and 160 examples are organized in treatment, matched group 77 examples.The curative effect of treatment flu is as follows:

Table 3-1 Syndrome in TCM marquis curative effect

U＝3.863 P＝0.001

Above result shows: treat after 3 days, treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is better than matched group.

Two groups of patient's total marks improvement of table 3-2 comparison (x ± SD)

Treatment back treatment group and matched group total mark compare: t=3.616 P=0.001

Treatment group and matched group difference compare: t=2.381 P=0.018

By table 3-2 as seen, the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, learns by statistics and handles (paired t-test), and significant difference is all arranged; Two groups of treatment back integrations compare, and the treatment group is lower than matched group, and significant difference is arranged; The comparison of the difference of two groups of symptom and sign total mark improvement, the treatment group is better than matched group, and significant difference is arranged.

2, the comparison of two groups of treatment back state of an illness

Table 4-1 treats back 3 days symptoms, signs for two groups and compares

Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.

Symptom, sign improvement degree such as two groups of treatment back heatings of table 4-2, aversion to cold are relatively ^*

^*Improve 1 grade of expression: reduced by 1 grade before the treatment in 3 days behind the symptom treatment

^*Improve 2 grades of expressions: reduced by 2 grades before the treatment in 3 days behind the symptom treatment

^*Improve 3 grades of expressions: reduced by 3 grades before the treatment in 3 days behind the symptom treatment

Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is better than matched group, have outside the significant difference, all the other there are no significant differences.

Four, conclusion

Comparability detects and to show before the treatment, symptom, signs such as two groups of heatings, aversion to cold, nasal obstruction, watery nasal discharge, dizziness, headache, limb aching pain relatively, aspects such as total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Treat that the tcm syndrome efficacy result shows after 3 days: treatment group clinical recovery rate is 40.0%, and obvious effective rate is 47.5%, and effective percentage is 11.3%, and inefficiency is 1.3%; Matched group clinical recovery rate is 19.5%, and obvious effective rate is 50.6%, and effective percentage is 26.0%, and inefficiency is 3.9%.Credit is analysed by statistics, and Syndrome in TCM marquis curative effect has significant difference between two groups, and treatment group curative effect is better than matched group.

Treat back 3 days symptoms, signs for two groups and compare, the order of severity of symptom and signs such as the heating of treatment group, nasal obstruction, dizziness headache, breast gastral cavity feeling of distension and oppression, diet minimizing, limb aching pain is lighter than matched group, and significant difference is arranged; All the other aversion to cold etc. are there was no significant difference relatively.Symptoms, sign improvement degree such as two groups of treatment back heatings, aversion to cold relatively except that the improvement degree of treatment group pharyngalgia, limb aching pain is better than matched group, have outside the significant difference, all the other there are no significant differences.

In sum, Drug therapy flu of the present invention (wind and cold is held the wet card that stagnates of holding under the arm under the arm) has obvious curative effects, is better than contrasting the medicine HUOXIANGZHENGQI KOUFUYE, and its clinical recommended dose is safe.

Test example 2: Drug therapy acute gastroenteritis of the present invention clinical research

One. qualified experimenter's selection

The wet resistance of dyspepsia (acute gastroenteritis): chest distress, belch acid regurgitation, nausea and vomiting, anorexia, stomachache discomfort, the smelly or water sample in big loose stool, light red tongue or light red, tongue is thick in vain, relaxed and soft pulse or stringy and rolling pulse.

(2) Western medicine diagnose standard: acute gastroenteritis [with reference to " modern Chinese medicine emergency case internal medicine "]

Acute gastroenteritis is because of improper diet or takes food and invade the caused digestive tract acute inflammation of gastrointestinal by the food of antibacterial, bacteriotoxin pollution and by virus.Clinical manifestation is primary symptom person with vomiting, upper abdominal pain, is called acute gastritis; Clinical manifestation is primary symptom person with diarrhoea, stomachache, is called acute enteritis; Clinical manifestation is primary symptom person with vomiting, stomachache, diarrhoea, then is called acute gastroenteritis.The person of being in a bad way can cause dehydration, acidosis even shock.

(1) acute simple gastritis

1. unclean feed, eating and drinking too much at one meal or eating cold and uncooked food excessively diet are arranged, indulge in excessive drinking, take the zest pharmacohistory;

2. morbidity is anxious, generally morbidity in a few hours to 24 hour on the feed;

3. stomachache can alleviate after Upper abdominal pain, belch, loss of appetite, nausea and vomiting, the vomiting;

4. because of bacterial infection causes patient's acute enteritis that often occurs together stomachache, diarrhoea, watery stool etc. are arranged;

5. physical examination can have upper abdominal pain or all tenderness of umbilicus, bowel sounds active or hyperfunction slightly.

(2) acute enteritis

1. with diarrhoea cardinal symptom, Acute onset, diarrhoea every day for several times surplus 10 time, is yellow water sample loose stool or foam, mucus, pus and blood etc. is arranged;

2. the multidigit of suffering from abdominal pain is in umbilicus week, with tenderness in various degree;

3. epigastric discomfort can be arranged, feel sick, vomiting, abdominal distention etc.;

4. how normal body temperature is, or heating etc. is arranged.Severe patient can cause dehydration, acidosis, shock etc.;

5. stool is cultivated and often can find pathogenic bacterium.

Two. the clinical implementation scheme

(1) test method: adopt the randomized controlled trial method

(2) selection of contrast medicine: select HUOXIANGZHENGQI KOUFUYE for use

(3) usage and dosage

(4) course of treatment: 3 days.

(5) observation index

The health giving quality observation item

(1) related symptoms and sign: as dizziness, headache, limb aching pain, chest distress, nausea and vomiting, diet minimizing, belch acid regurgitation, epigastric pain, loose stool etc.

Symptom scalar quantization table

Symptom	Do not have (0 grade)	Gently (I level)	In (II level)	Heavy (III level)
					Dizziness headache	Do not have (0 minute)	Dizzy pain is light, the time end (1 minute) when doing	Heavier, continue more than (2 minutes)	Dizziness headache can not be adhered to work (3 minutes)
Limb aching pain	Do not have (0 minute)	Slightly ache (1 minute)	Ache obviously (2 minutes)	Ache and accompany joint stuffiness (3 minutes)
					Fullness in the epigastrium and chest	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Obvious feeling of distension and oppression, but can stand slight effect work and rest (2 minutes)	Distension continues the alleviation of need taking medicine (3 minutes) unbearably
The belch acid regurgitation	Do not have (0 minute)	Idol has belch acid regurgitation (1 minute)	The time belch acid regurgitation (2 minutes) arranged	Frequent belch acid regurgitation (3 minutes)
					Nausea and vomiting	Do not have (0 minute)	Idol has nauseating (1 minute)	In the time, have nauseatingly, and idol has a vomiting (2 minutes)	Frequent nauseating, vomiting (3 minutes) sometimes
Diet reduces	Do not have (0 minute)	Appetite reduces (1 minute)	Appetite reduces by 1/3 (2 minutes)	Appetite reduces by 1/2 (3 minutes)
					Epigastric pain	Do not have (0 minute)	Slightly, in time, end when doing, and do not influence work and rest (1 minute)	Pain can be stood, and it is lighter to show effect, and influences work and rest (2 minutes)	Pain continues incessantly the alleviation of need taking medicine (3 minutes) unbearably
Loose stool	Do not have (0 minute)	It is shapeless to defecate, every day 1～3 time (1 minute)	Loose stool, every day 4～6 times (2 minutes)	The stool water sample, every day is (3 minutes) more than 7 times

Three, efficacy assessment standard

1, acute gastroenteritis curative effect determinate standard

(1) clinical recovery: clinical symptoms, sign disappear, and it is normal that physico-chemical examination recovers.Integration reduces 〉=95%.

(2) produce effects: clinical cardinal symptom, sign disappear substantially, and integration subtracts 〉=and 70%, physico-chemical examination obviously improves.

(3) effective: cardinal symptom, sign alleviate, and integration reduces 〉=30%, and physico-chemical examination makes moderate progress.

(4) invalid: as not reach above-mentioned effective standard or deterioration person.

2, acute gastroenteritis therapeutic effect of syndrome criterion

Computational methods (nimodipine method):

Four, statistical procedures

Statistical method:

Acute gastroenteritis as a result

One, physical data

This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.Chinese medical discrimination is the dyspepsia dampness, and Western medicine diagnose is an acute gastroenteritis.Outpatient's 224 examples, inpatient's 15 examples.

Two, comparability inspection before the treatment

2, two groups of preceding state of an illness of treatment relatively

Local comparison with General Symptoms such as two groups of 2-1 of table treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation

Local comparison with General Symptoms such as two groups of treatment shirtfront gastral cavity feeling of distension and oppression, belch acid regurgitation, difference that there are no significant.

Stool antibacterial culturing situation relatively before two groups of treatments of table 2-2

Stool antibacterial culturing situation compares there was no significant difference before two groups of treatments.

Comparability detects and shows before the above-mentioned treatment, two groups of gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache, aspects such as stool antibacterial culturing situation, total mark relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Three, efficacy analysis

1, total effects analysis

This research has qualified experimenter's 239 examples, and 161 examples are organized in treatment, matched group 78 examples.The curative effect of treatment acute gastroenteritis (dyspepsia dampness) is as follows:

Two groups of curative effect of disease of table 3-1 relatively

U＝2.631 P＝0.009

Above result shows: treat after 3 days, treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group curative effect of disease is better than matched group, and significant difference is arranged.

Table 3-2 Syndrome in TCM marquis curative effect

U＝2.818 P＝0.005

Above result shows: treat after 3 days, treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group Syndrome in TCM marquis curative effect is better than matched group, and significant difference is arranged.

Two groups of patient's total marks improvement of table 3-3 comparison (x ± SD)

Treatment back treatment group and matched group total mark compare: t=2.240 P=0.026

Treatment group and matched group difference compare: t=0.653 P=0.515

By table 3-3 as seen, the symptom and sign total mark is improved relatively before and after treatment group and the treatment of control group, learns by statistics and handles (paired t-test), and significant difference is all arranged; Treatment back treatment group and matched group total mark compare, and difference has significance; The comparison of the difference of two groups of symptom and sign total mark improvement, there was no significant difference.

2, the comparison of two groups of treatment back state of an illness

Table 4-1 treats back 1 day symptom, sign for two groups and compares

Treat back 1 day symptom relatively for two groups, the order of severity of treatment group nausea and vomiting, epigastric pain, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.

Table 4-2 treats back 2 days symptoms, signs for two groups and compares

Treat back 2 days symptoms relatively for two groups, the order of severity of treatment group nausea and vomiting, limb aching pain, dizziness headache is lighter than matched group, and significant difference is arranged, there was no significant differences such as all the other breast gastral cavity feeling of distension and oppression.

Table 4-3 treats back 3 days symptoms, signs for two groups and compares

Treat back 3 days symptoms relatively for two groups, treatment group breast gastral cavity feeling of distension and oppression, nausea and vomiting, diet reduce, the order of severity of loose stool is lighter than matched group, significant difference are arranged, there was no significant differences such as all the other belch acid regurgitations.

Whole body and local circumstance's improvement degree comparisons such as two groups of treatments of table 4-4 metathorax gastral cavity feeling of distension and oppression ^*

^*Improve 1 grade of expression: reduce by 1 grade before the 3 big treatments behind the symptom treatment

Two groups of whole body and local circumstance's improvement degree comparisons such as treatment metathorax gastral cavity feeling of distension and oppression, difference that there are no significant.

The treatment group has two example stool positive bacterial culture before treating, and treats the back check and all transfers feminine gender to.

3, the situation that clinical adverse occurs

All untoward reaction does not all appear in case.

Four, conclusion

Comparability detects and shows before the treatment, two groups of sexes, age, the course of disease, previously treatment, gastral cavitys are coerced part and General Symptomies such as distension, belch acid regurgitation, nausea and vomiting, epigastric pain, diet minimizing, loose stool, limb aching pain, dizziness headache, aspects such as stool antibacterial culturing situation, total mark, body of the tongue, tongue fur, pulse condition relatively, difference there are no significant meaning.The principal element that prompting influences two groups of curative effects has harmony, shows that two groups have comparability.

Treat that the curative effect of disease result of study shows after 3 days: treatment group clinical recovery rate is 72.7%, and obvious effective rate is 20.5%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group curative effect of disease is better than matched group, and significant difference is arranged.

Treat that Syndrome in TCM marquis effectiveness study result shows after 3 days: treatment group clinical recovery rate is 73.9%, and obvious effective rate is 19.3%, and effective percentage is 3.1%, and inefficiency is 3.7%; Matched group clinical recovery rate is 55.1%, and obvious effective rate is 33.3%, and effective percentage is 9.0%, and inefficiency is 2.6%.Credit is analysed by statistics, and treatment group Syndrome in TCM marquis curative effect is better than matched group, and significant difference is arranged.

In sum, Drug therapy acute gastroenteritis of the present invention (dyspepsia dampness) has obvious curative effects, and its clinical recommended dose is safe.

Further set forth the preparation method of medicine of the present invention by the following examples.

Embodiment 1:

A. hook taking rattan 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby;

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 2 times of water loggings bubbles after 2 hours, adopted vapor distillation 3 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water 3 times, add 3000L water at every turn, decoct 2 hours, and collecting decoction filters, and filtrate is concentrated into relative density 1.04～1.20 in the time of 65 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 50%～55%, leave standstill 36 hours, filter, and reclaim ethanol; Be concentrated into relative density 1.25～1.45 in the time of 65 ℃～75 ℃, get extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water 3 times, add the 3000L decocting at every turn and boiled 3 hours, collecting decoction filters, filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～60 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 40%, left standstill 16 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～60 ℃, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water 3 times, decoct 2 hours at every turn, add 3000L water at every turn, collecting decoction filters, and filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～60 ℃, puts cold, add ethanol and make and contain the alcohol amount and reach 45%, left standstill 16 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～60 ℃, get extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, add decocting 3 times, add the 3000L decocting at every turn and boiled 3 hours, collecting decoction filters, filtrate is concentrated to relative density 1.01～1.15 in the time of 65 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 60%～70%, left standstill 36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.02～1.20 in the time of 65 ℃～70 ℃, get extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 100L, stir, filter; Add sucrose in filtered solution, thin up is to 300L, and stirring makes dissolving, and heated and boiled 1 hour is filtered, in filtered solution, add water to 1000L, stir, put cold, to below 60 ℃, filter, add deployed Aromatic water solution, stir, add water to 1000L; Embedding, gland, 115～135 ℃ of pressure sterilizings 10 minutes, packing promptly gets the oral liquid finished product.

Embodiment 2:

A. hook taking rattan 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby;

Get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 2 times of water loggings bubbles after 0.5 hour, adopted vapor distillation 3 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water 1 time, add 1000L water at every turn, decoct 1 hour, and collecting decoction filters, and filtrate is concentrated into relative density 1.04～1.20 in the time of 75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 55%, leave standstill 36 hours, filter, and reclaim ethanol; Be concentrated into relative density 1.25～1.45 in the time of 75 ℃, get extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, add decocting 3 times, add the 1000L decocting at every turn and boiled 1～3 hour, collecting decoction filters, filtrate is concentrated into relative density 1.02～1.05 in the time of 45 ℃～75 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 40%, left standstill 36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 45 ℃～75 ℃, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water 1 time, decoct 0.5 hour at every turn, add 1000L water at every turn, collecting decoction filters, and filtrate is concentrated into relative density 1.02～1.05 in the time of 45 ℃, puts cold, add ethanol and make and contain the alcohol amount and reach 35%, left standstill 36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 75 ℃, get extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water 1～3 time, add the 1000L decocting at every turn and boiled 0.5 hour, collecting decoction filters, filtrate is concentrated to relative density 1.01～1.15 in the time of 45 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 50%, left standstill 36 hours, filter, reclaim ethanol; Be concentrated into relative density 1.02～1.20 in the time of 75 ℃, get extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 25L, stir, filter; Add sucrose in filtered solution, thin up is to 100L, and stirring makes dissolving, heated and boiled 0.2 hour, filter, in filtered solution, add water to 300L, stir, put cold, to 10 ℃ of filtrations, add deployed Aromatic water solution, stir, add water to 300L; Embedding, gland, 135 ℃ of pressure sterilizings 30 minutes, packing promptly gets the oral liquid finished product.

Embodiment 3:

A. hook taking rattan 15.50g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 95.20g are standby;

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 2 times of water loggings bubbles after 2 hours, adopted vapor distillation 3 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water 3 times, add 2000L water at every turn, decoct 1.5 hours, and collecting decoction filters, and filtrate is concentrated into relative density 1.04～1.20 in the time of 60 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 50%, leave standstill 24 hours, filter, and reclaim ethanol; Be concentrated into relative density 1.25～1.45 in the time of 55 ℃～65 ℃, get extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water 2 times, add the 1500L decocting at every turn and boiled 1.5 hours, collecting decoction filters, filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～65 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 30%, left standstill 4 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～65 ℃, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water 2 times, decoct 1.5 hours at every turn, add 2000L water at every turn, collecting decoction filters, and filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～65 ℃, puts cold, add ethanol and make and contain the alcohol amount and reach 55%, left standstill 4 hours, filter, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 45 ℃～55 ℃, get extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water 2 times, add the 1500L decocting at every turn and boiled 2 hours, collecting decoction filters, filtrate is concentrated to relative density 1.01～1.15 in the time of 45 ℃～55 ℃, put coldly, add ethanol and make and contain the alcohol amount and reach 50%～55%, left standstill 4 hours, filter, reclaim ethanol; Be concentrated into relative density 1.02～1.20 in the time of 45 ℃～50 ℃, get extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 80L, stir, filter; Add sucrose in filtered solution, thin up is to 150L, and stirring makes dissolving, heated and boiled 1 hour, filter, in filtered solution, add water to 500L, stir, put cold, to 20 ℃ of filtrations, add deployed Aromatic water solution, stir, add water to 500L; Embedding, gland, 115 ℃ of pressure sterilizings 10 minutes, packing promptly gets the oral liquid finished product.

Embodiment 4:

A. hook taking rattan 41.20g, Cortex Magnoliae Officinalis 163.68g, Radix Trichosanthis 123.17g, Poria 327.85g, Radix Angelicae Dahuricae 165.56g, Guangdong Massa Medicata Fermentata 165.56g, Fructus Tribuli 41.20g, Rhizoma Atractylodis 163.68g, Radix Puerariae 163.68g, Exocarpium Citri Grandis 81.73g, Fructus Oryzae Germinatus 123.17g, Flos Chrysanthemi 81.73g, Radix Aucklandiae 163.68g, Herba Pogostemonis 163.6g, Herba Menthae 81.73g, Semen Coicis 206.10g are standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water secondary, the each decoction 1 hour adds 2000L water for the first time, adds 1500L water for the second time, collecting decoction, filter, filtrate is concentrated into relative density 1.02～1.05 in the time of 55 ℃～60 ℃, puts cold, adding ethanol makes and contains the alcohol amount and reach 45%, left standstill 12 hours, and filtered, reclaim ethanol; Be concentrated into relative density 1.05～1.10 in the time of 55 ℃～60 ℃, get extractum three, standby;

C. the preparation of fragrant solution: earlier required Polysorbate～80 are placed in the beaker, add volatile oil then, be stirred to mix homogeneously, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 50L, stir, filter; Add sucrose in filtered solution, thin up is to 200L, and stirring makes dissolving, heated and boiled 0.5 hour, filter, in filtered solution, add water to 600L, stir, put cold, to 30 ℃ of filtrations, add deployed Aromatic water solution, stir, add water to 600L; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes, packing promptly gets the oral liquid finished product.

Embodiment 5:

A. hook taking rattan 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby; More than 16 flavor medical materials, decoct with water 3 times, decocted 4 hours at every turn, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.20 in the time of 45 ℃～50 ℃, puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 10%%, left standstill 36 hours, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.01～1.25 in the time of 45 ℃～50 ℃, it is standby to get extractum;

C. oral liquid preparation: extractum in stainless steel cask, is added water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 2 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 60 ℃, filter, add deployed fragrant solution, it is standby to stir; Embedding, gland, 130 ℃ of pressure sterilizings 30 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 6

A. hook taking rattan 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby; More than 16 flavor medical materials, decoct with water 2 times, decocted 0.5 hour at every turn, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.20 in the time of 65 ℃～70 ℃, puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 30%～40%, left standstill 24 hours, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.01～1.25 in the time of 65 ℃～70 ℃, it is standby to get extractum;

C. oral liquid preparation: extractum in stainless steel cask, is added water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1.5 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 25 ℃, filter, add deployed fragrant solution, it is standby to stir; Embedding, gland, 125 ℃ of pressure sterilizings 60 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 7

A. hook taking rattan 34.10g, Cortex Magnoliae Officinalis 136.40g, Radix Trichosanthis 102.30g, Poria 272.80g, Radix Angelicae Dahuricae 136.40g, Guangdong Massa Medicata Fermentata 136.40g, Fructus Tribuli 34.10g, Rhizoma Atractylodis 136.40g, Radix Puerariae 136.40g, Exocarpium Citri Grandis 68.20g, Fructus Oryzae Germinatus 102.30g, Flos Chrysanthemi 68.20g, Radix Aucklandiae 136.40g, Herba Pogostemonis 136.40g, Herba Menthae 68.20g, Semen Coicis 170.50g are standby;

Extract volatile oil: get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 1 times of drinking water and soak after 1 hour, adopted vapor distillation 2 hours, collect volatile oil device preservation in addition; Medicinal residues add drinking water and decoct secondary, add the 1500L drinking water at every turn, decoct collecting decoction 1.5 hours, filter, filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.08～1.12, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 45%, left standstill 16 hours, and filtered, reclaim ethanol; Be concentrated into relative density 1.25～1.30 (55 ℃～60 ℃), it is standby to get extractum one;

B. hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, add drinking water and decoct secondary, add the 2000L drinking water for the first time and decocted 2 hours, add the 1500L drinking water for the second time and decocted 1.5 hours, collecting decoction, filter, filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.05 (, put cold, adding ethanol makes and contains the alcohol amount and reach 40%, left standstill 8～16 hours, and filtered, reclaim ethanol; Be concentrated in the time of 55 ℃～60 ℃, relative density 1.05～1.10, extractum two standby;

C. get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and add drinking water and decoct secondary, the each decoction 1 hour adds the 2000L drinking water for the first time, adds the 1500L drinking water for the second time, collecting decoction, filter, filtrate is concentrated into relative density 1.02～1.05 (55 ℃～60 ℃), puts cold, adding ethanol makes and contains the alcohol amount and reach 45%, left standstill 8～16 hours, and filtered, reclaim ethanol; Be concentrated in the time of 55 ℃～60 ℃, relative density 1.05～1.10, extractum three standby;

D. get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, add drinking water and decoct secondary, add the 2000L drinking water for the first time and decocted 2 hours, add the 1500L drinking water for the second time and decocted 1 hour, collecting decoction, filter, filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.05, puts cold, adding ethanol makes and contains the alcohol amount and reach 60%, left standstill 16 hours, and filtered, reclaim ethanol; Be concentrated in the time of 55 ℃～60 ℃, relative density 1.05～1.10, extractum four standby;

(e). the preparation of fragrant solution: earlier required Polysorbate～80 are placed in the beaker, add volatile oil then, be stirred to mix homogeneously, standby;

(f). oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 50L, stir, filter; Add sucrose in filtered solution, thin up is to 200L, and stirring makes dissolving, and heated and boiled 0.5 hour is filtered, in filtered solution, add water to 600L, stir, put cold, to 37 ℃, filter, add deployed Aromatic water solution, stir, add water to 600L; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 8

A. hook taking rattan 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby; More than 16 flavor medical materials, add drinking water and decoct secondary, decocted 1～3 hour for the first time, decocting boiled 1～2 hour for the second time, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.11 (55 ℃～60 ℃), puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 20～80%, left standstill 4～24 hours, filter, reclaim ethanol; Concentrate: be concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.15, extractum is standby;

B. the preparation of fragrant solution: earlier required Polysorbate～80 are placed in the vessel, add the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, Exocarpium Citri Grandis volatile oil then, be stirred to mix homogeneously, standby;

C. oral liquid preparation: extractum in stainless steel cask, is added water, stir, filter.Sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, and heated and boiled 0.5 hour is filtered to medicinal liquid clarification, adds water to requirement, stirs, and puts coldly, to 5 ℃, filters, and adds deployed fragrant solution, and it is standby to stir; Embedding, gland, 130 ℃ of pressure sterilizings 15 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 9

A. hook taking rattan 27.17g, Cortex Magnoliae Officinalis 109.12g, Radix Trichosanthis 81.80g, Poria 217.94g, Radix Angelicae Dahuricae 109.12g, Guangdong Massa Medicata Fermentata 109.12g, Fructus Tribuli 27.17g, Rhizoma Atractylodis 109.12g, Radix Puerariae 109.12g, change Fructus Citri tangerinae 54.48g, Fructus Oryzae Germinatus 81.80g, Flos Chrysanthemi 54.48, Radix Aucklandiae 109.12g, Herba Pogostemonis 109.12g, Herba Menthae 54.48g, Semen Coicis 136.77g are standby;

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 2 times of water loggings bubbles after 2 hours, adopted vapor distillation 3 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water 3 times, add 3000L water at every turn, decoct collecting decoction 2 hours, filter, filtrate is concentrated in the time of 45 ℃～55 ℃, relative density 1.04～1.20, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 40%～55%, left standstill 4～36 hours, and filtered, reclaim ethanol; Be concentrated in the time of 45 ℃～55 ℃, relative density 1.25～1.45, extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water 1～3 time, add the 3000L decocting at every turn and boiled 3 hours, collecting decoction filters, filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.05, put coldly, add ethanol and make and contain the alcohol amount and reach 40%, left standstill 16 hours, filter, reclaim ethanol; Be concentrated into 55 ℃～60 o'clock, relative density 1.05～1.10, get extractum two, standby;

Get Semen Coicis, Fructus Oryzae Germinatus two flavor medical materials merge, and decoct with water 3 times, decoct 2 hours at every turn, add 3000L water at every turn, collecting decoction filters, and filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.05, puts cold, add ethanol and make and contain the alcohol amount and reach 45%, left standstill 16 hours, filter, reclaim ethanol; Be concentrated in the time of 55 ℃～60 ℃, relative density 1.05～1.10, extractum three, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water 3 times, add the 3000L decocting at every turn and boiled 3 hours, collecting decoction filters, when filtrate is concentrated to 45 ℃～75 ℃, relative density 1.01～1.15, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, left standstill 36 hours, filter, reclaim ethanol; Be concentrated in the time of 45 ℃～70 ℃, relative density 1.02～1.20, extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 100L, stir, filter; Add sucrose in filtered solution, thin up is to 300L, and stirring makes dissolving, heated and boiled 1 hour, filter, in filtered solution, add water to 1000L, stir, put cold, filter below 40 ℃, add deployed Aromatic water solution, stir, add water to 1000L; Embedding, gland, 135 ℃ of pressure sterilizings 30 minutes, packing promptly gets the oral liquid finished product.

Embodiment 10

B. get the Radix Aucklandiae, Rhizoma Atractylodis, Herba Menthae, Herba Pogostemonis, the merging of Exocarpium Citri Grandis five tastes medical material, add 1 times of water logging bubble after 1 hour, adopted vapor distillation 1.5 hours, collect volatile oil device preservation in addition; Medicinal residues decoct with water 2 times, add 1000 water at every turn, decoct 1 hour at every turn, and collecting decoction filters, and filtrate is concentrated into 65 ℃～75 o'clock, relative density 1.04～1.20, put coldly, add ethanol and make and contain the alcohol amount and reach 45%, leave standstill 4 hours, filter, and reclaim ethanol; Be concentrated in the time of 65 ℃～75 ℃, relative density 1.25～1.45, extractum one, standby;

Hook taking rattan, Fructus Tribuli, Flos Chrysanthemi, Cortex Magnoliae Officinalis, Guangdong Massa Medicata Fermentata five tastes medical material merge, decoct with water 2 times, add the 2000L decocting at every turn and boiled 2.5 hours, collecting decoction filters, filtrate is concentrated in the time of 55 ℃～60 ℃, relative density 1.02～1.05, put coldly, add ethanol and make and contain the alcohol amount and reach 40%, left standstill 8 hours, filter, reclaim ethanol; Be concentrated in the time of 55 ℃～60 ℃, relative density 1.05～1.10, extractum two, standby;

Get Poria, Radix Trichosanthis, the Radix Angelicae Dahuricae, the merging of Radix Puerariae four Chinese medicine material, decoct with water 2 times, add the 1000L decocting at every turn and boiled 1.5 hours, collecting decoction filters, filtrate is concentrated to, relative density 1.01～1.15 at 45 ℃～75 o'clock, put coldly, add ethanol and make and contain the alcohol amount and reach 65%, left standstill 24 hours, filter, reclaim ethanol; When being concentrated into 45 ℃～70 ℃, relative density 1.02～1.20, extractum four, standby;

D. oral liquid preparation: take by weighing above-mentioned four kinds of extractum of dosage, add water to about 25L, stir, filter; Add sucrose in filtered solution, thin up is to 100L, and stirring makes dissolving, heated and boiled 1 hour, filter, in filtered solution, add water to 300L, stir, put cold, to 50 ℃ of filtrations, add deployed Aromatic water solution, stir, add water to 300L; Embedding, gland, 115 ℃ of pressure sterilizings 10 minutes, packing promptly gets the oral liquid finished product.

Embodiment 11

A. hook taking rattan 55.80g, Cortex Magnoliae Officinalis 215.50g, Radix Trichosanthis 205.80g, Poria 423.20g, Radix Angelicae Dahuricae 215.50g, Guangdong Massa Medicata Fermentata 215.50g, Fructus Tribuli 55.80g, Rhizoma Atractylodis 215.50g, Radix Puerariae 215.50g, Exocarpium Citri Grandis 125.40g, Fructus Oryzae Germinatus 205.80g, Flos Chrysanthemi 125.40g, Radix Aucklandiae 215.50g, Herba Pogostemonis 215.50g, Herba Menthae 125.40g, Semen Coicis 324.80g are standby; More than 16 flavor medical materials, decoct with water 2 times, decocted 3 hours for the first time, decocted 1 hour for the second time, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.20 (45 ℃～50 ℃), puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 30～50%, left standstill 12 hours, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.01～1.25 (45 ℃～50 ℃ meters), it is standby to get extractum;

C. oral liquid preparation: extractum in stainless steel cask, is added water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1.5 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 20 ℃ of filtrations, add deployed fragrant solution, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 60 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 12

A. hook taking rattan 15.50g, Cortex Magnoliae Officinalis 80.40g, Radix Trichosanthis 55.50g, Poria 155.60g, Radix Angelicae Dahuricae 80.40g, Guangdong Massa Medicata Fermentata 80.40g, Fructus Tribuli 15.50g, Rhizoma Atractylodis 80.40g, Radix Puerariae 80.40g, Exocarpium Citri Grandis 36.70g, Fructus Oryzae Germinatus 55.50g, Flos Chrysanthemi 36.70g, Radix Aucklandiae 80.40g, Herba Pogostemonis 80.40g, Herba Menthae 36.70g, Semen Coicis 95.20g are standby; More than 16 flavor medical materials, decoct with water 3 times, decocted 4 hours for the first time, decocted 2 hours for the second time, decocted for the third time 0.5 hour, collecting decoction filters, filtrate is concentrated into relative density 1.01～1.20 (45 ℃～70 ℃), puts cold; Precipitate with ethanol, reclaim ethanol: add ethanol and make and contain the alcohol amount and reach 85%, left standstill 36 hours, filter, reclaim ethanol; Concentrate: be concentrated into relative density 1.01～1.25 (45 ℃～70 ℃ meters), it is standby to get extractum;

C. oral liquid preparation: extractum in stainless steel cask, is added water, stir, filter.Sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 2 hours, be filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to filtering below 60 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 130 ℃ of pressure sterilizings 30 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 13

A. get prescription, it is standby with embodiment 1 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 4 times, and each 0.2 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 4 times, and each 3 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 65%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 4 times, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1～4 time, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 4 times with 85% alcohol heating reflux respectively, and each 3.5 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 4 times with 85% alcohol heating reflux, and each 3.5 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 14% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 95 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 2 hours is filtered, and adds water to requirement, stir, put coldly,, filter to 35 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 120 ℃ of pressure sterilizings 60 minutes promptly get the oral liquid finished product.

Embodiment 14

A. get prescription, it is standby with embodiment 3 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 1 time, extract 3 hours, filter, and merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 1 time, extract 3 hours, filter, and merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 30%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 1 time, extracts 1.5 hours, filters, and merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 1 time, extract 3 hours, filter, and merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 1 time with 50～85% alcohol heating reflux respectively, extract 3.5 hours, filter, and merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 1 time with 50% alcohol heating reflux, extracts 3.5 hours, filters, and merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 6% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 50 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.2 hour is filtered, and adds water to requirement, stir, put coldly,, filter to 20 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 110 ℃ of pressure sterilizings 10 minutes promptly get the oral liquid finished product.

Embodiment 15

A. get prescription, it is standby with embodiment 4 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 3 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and each 1.5 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2 times, and each 3 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 65% alcohol heating reflux respectively, and each 2.5 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 55% alcohol heating reflux, and each 1.5 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 7% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 55 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.2～2 hour is filtered, and adds water to requirement, stir, put coldly,, filter to 40 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 110～130 ℃ of pressure sterilizings 10～60 minutes promptly get the oral liquid finished product.

Embodiment 16

A. get prescription, it is standby with embodiment 5 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, and each 2 hours, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 55%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2～3 times, and each 2 hours, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 3 times with 80% alcohol heating reflux respectively, and each 3 hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 80% alcohol heating reflux, and each 3 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 90 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 1 hour is filtered, and adds water to requirement, stir, put coldly,, filter to below 60 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 125 ℃ of pressure sterilizings 40 minutes promptly get the oral liquid finished product.

Embodiment 17

A. get prescription, it is standby with embodiment 6 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate, filtrate are concentrated in right amount, add ethanol and make and contain alcohol amount and reach 35%, standing over night, filter, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 3 times, and 1 hour for the first time, 0.5 hour for the second time, 0.2 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 3 times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis are carried 3 times with 60% alcohol heating reflux respectively, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 3 times with 60% alcohol heating reflux, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, filter, filtrate is concentrated into the thick paste shape with 12% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 80 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.5 hour is filtered, and adds water to requirement, stir, put coldly,, filter to 30 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 115 ℃ of pressure sterilizings 40 minutes promptly get the oral liquid finished product.

Embodiment 18

A. get prescription, it is standby with embodiment 7 to write out a prescription;

B. above ten Six-elements, Herba Pogostemonis, the Radix Aucklandiae, Herba Menthae, Rhizoma Atractylodis extract volatile oil with steam distillation respectively, and volatile oil device is in addition preserved, and medicinal residues decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Massa Medicata Fermentata, Poria decoct with water respectively 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate, filtrate is concentrated in right amount, and add ethanol and make and contain the alcohol amount and reach 45%, standing over night, filtration, filtrate recycling ethanol is concentrated into the thick paste shape, and is standby; Fructus Oryzae Germinatus decocts with water 2 times, and 1 hour for the first time, 0.5 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Cortex Magnoliae Officinalis, Fructus Tribuli, Flos Chrysanthemi decoct with water respectively 2 times, and 2 hours for the first time, 1 hour for the second time, filter, merging filtrate is concentrated into the thick paste shape, and is standby; The Radix Angelicae Dahuricae, Exocarpium Citri Grandis, Radix Puerariae, Radix Trichosanthis extract 2 times with 60～80% alcohol heating reflux respectively, and 3 hours for the first time, 1 hour for the second time, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste shape, and is standby; Ramulus Uncariae Cum Uncis extracts 2 times with 65% alcohol heating reflux, and each 2 hours, filter, merging filtrate with hydrochloric acid adjust pH to 3～4, fully stirs, and filters, and filtrate is concentrated into the thick paste shape with 8% sodium carbonate liquor adjust pH to 6～7, and is standby; Semen Coicis is ground into fine powder 60 ℃ of oven dry, and is standby;

D. oral liquid preparation: get above-mentioned extractum and the Semen Coicis fine powder adds water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 1 hour is filtered, and adds water to requirement, stir, put coldly,, filter to 45 ℃, add deployed fragrant solution, it is standby to stir; Embedding, gland, 105 ℃ of pressure sterilizings 15～40 minutes promptly get the oral liquid finished product.

Embodiment 19

Embodiment 20

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 100 ℃ with 12 times of water gagings, and each 5 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 12 times of amount ethanol of 80%, and each 5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 80 ℃;

C. oral liquid preparation: qinghuo reagent I, clear paste II merge, and add the oral liquid dissolved volatile oil of aromatic commonly used, make oral liquid according to the conventional preparation method of oral liquid.

Embodiment 21

A. get prescription, it is standby with embodiment 2 to write out a prescription;

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 35 ℃ with 2 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 2 times at 100 ℃ with 2 times of amount ethanol of 30%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;

C. clear paste I and the clear paste II that makes merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 2 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 130 ℃ of pressure sterilizings 60 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 22

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 6 times of water gagings, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 8 times of amount ethanol of 50%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 70 ℃;

C. clear paste I and the clear paste II that makes merged, add water, stir, filter, monosaccharide is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 2 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 110 ℃ of pressure sterilizings 10 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 23

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil gets cyclodextrin clathrate, and is standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 3 times at 90 ℃ with 8 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2～3 times at 80 ℃ with 8 times of amount ethanol of 70%, and each 3 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 70 ℃;

C. clear paste I and the clear paste II that makes merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 50 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 120 ℃ of pressure sterilizings 12 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 24

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 50 ℃ with 3 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 3 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;

C. clear paste I and the clear paste II that makes merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1.5 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 20 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 115 ℃ of pressure sterilizings 35 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 25

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 60 ℃ with 7 times of water gagings, and 2.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 4 times of amount ethanol of 60%, and 2 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 60 ℃;

C. clear paste I and the clear paste II that makes merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 4 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 50 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 100 ℃ of pressure sterilizings 40 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 26

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 65 ℃ with 3 times of water gagings, and 1.5 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 65 ℃; Medicinal residues after the extraction extract 2 times at 59 ℃ with 4 times of amount ethanol of 65%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;

C. clear paste I and the clear paste II that makes merged, add the oral liquid dissolved Radix Aucklandiae of aromatic commonly used, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae Haplocalycis volatile oil, make oral liquid according to the conventional preparation method of oral liquid.

Embodiment 27

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃;

C. clear paste I, clear paste II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 28

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 100 ℃ with 10 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 80 ℃; Medicinal residues after the extraction extract 3 times at 35 ℃ with 5 times of amount ethanol of 80%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 80%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 20000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 5 times of column volumes 3 times, and 80% ethanol elution of 8 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 10 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 80% ethanol elution 3 times, eluting ethanol is 10 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing.

C. dry extract I and dry extract II merge, and add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 2 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 110 ℃ of pressure sterilizings 60 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 29

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 1 time at 35 ℃ with 2 times of water gagings, extracted 5 hours, and the merge extractive liquid, filtration, relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 35 ℃; Medicinal residues after the extraction extract 1 time at 100 ℃ with 2 times of amount ethanol of 30%, extract 5 hours, and merge extractive liquid, filters, extracting solution recovery ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 50%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.01～1.15, and is centrifugal with 5000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 2 times, and 20% ethanol elution of 3 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I;

C. dry extract I and clear paste II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 130 ℃ of pressure sterilizings 10 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 30

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 55 ℃ with 5.5 times of water gagings, and each 3 hours, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 55 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 5.5 times of amount ethanol of 55%, and each 2.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 35～80 ℃; Clear paste II adds water to and is diluted to density is 1.01～1.15, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5.5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. clear paste I and dry extract II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1.5 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 120 ℃ of pressure sterilizings 30 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 31

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 85 ℃ with 3 times of water gagings, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and relative density was that 1.05～1.30 clear paste I is standby when filtrate was concentrated into 75 ℃; Medicinal residues after the extraction extract 2 times at 75 ℃ with 7 times of amount ethanol of 75%, and 3 hours for the first time, 1 hour for the second time, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.05～1.30 clear paste II is standby when being concentrated into 75 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 60%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 10000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 2 times of column volumes 3 times, and 70% ethanol elution of 6 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 8 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 70% ethanol elution 3 times, eluting ethanol is 8 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. dry extract I and dry extract II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 2 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, add and use that an amount of Polysorbate--80 dissolved volatile oil add, and stir; Embedding, gland, 105 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 32

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 70 ℃ with 7 times of water gagings, and each 2.5 hours, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 70 ℃; Medicinal residues after the extraction extract 2 times at 40 ℃ with 4 times of amount ethanol of 40%, and each 1 hour, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 50 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 70%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 40～70% ethanol elution of 5 times of column volumes of reuse 3 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 2 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 60% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. dry extract I and dry extract II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 3 hours is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 150 ℃ of pressure sterilizings 15 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 33

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil, standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2～3 times at 80 ℃ with 4.5 times of water gagings, and each 1 hour, merge extractive liquid, filtered, and relative density was that 1.08～1.25 clear paste I is standby when filtrate was concentrated into 50 ℃; Medicinal residues after the extraction extract 2 times at 55 ℃ with 7.5 times of amount ethanol of 45%, and each 2 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.08～1.25 clear paste II is standby when being concentrated into 65 ℃;

Clear paste I adds ethanol to be made and contains alcohol amount and reach 75%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.10, and is centrifugal with 12000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 3 times of column volumes 1 time, and 60% ethanol elution of 6 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.10, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 7 times distilled water eluting of first usefulness column volume 3 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 2 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. dry extract I and dry extract II are merged, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 25 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 95 ℃ of pressure sterilizings 100 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 34

Clear paste I adds ethanol to be made and contains alcohol amount and reach 65%, leaves standstill, and filters, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and gets dry extract I; Clear paste II adds water to and is diluted to density is 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol gets dry extract II to dry to the greatest extent, pulverizing;

C. dry extract I and dry extract II are merged, add water, stir, filter, again sucrose is poured into wherein, added water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 35 active component preparation methoies of the present invention

B. get the Radix Aucklandiae, Herba Pogostemonis, Cortex Magnoliae Officinalis, Rhizoma Atractylodis, the Radix Angelicae Dahuricae, Herba Menthae 6 flavors, be ground into coarse powder, vapor extraction volatile oil; Standby; Medicinal residues and surplus stock medicine combine, and decoct to extract 2 times at 80 ℃ with 5 times of water gagings, and each 2 hours, merge extractive liquid, filtered, and relative density was that 1.10～1.20 clear paste I is standby when filtrate was concentrated into 60 ℃; Get part clear paste I and add ethanol and make and contain alcohol amount and reach 65%, leave standstill, filter, filtrate is concentrated into does not have the alcohol flavor, and thin up to density is 1.02～1.08, and is centrifugal with 15000 rev/mins rotating speed, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, earlier with the water elution of 4 times of column volumes 2 times, and 60% ethanol elution of 4 times of column volumes of reuse 2 times, merge ethanol elution, being recycled to does not have the alcohol flavor, merges with water elution liquid, concentrate, drying is pulverized, and it is standby to get dry extract I;

Medicinal residues after the extraction extract 2 times at 60 ℃ with 6 times of amount ethanol of 60%, and each 1.5 hours, merge extractive liquid, filtered, and extracting solution reclaims ethanol, and relative density is that 1.10～1.20 clear paste II is standby when being concentrated into 60 ℃; Get part clear paste II and add water to that to be diluted to density be 1.02～1.08, leave standstill, centrifugal, centrifugal liquid is crossed the macroporous adsorptive resins of having handled well, 5 times distilled water eluting of first usefulness column volume 2 times, and water liquid discards, reuse 65% ethanol elution 2 times, eluting ethanol is 4 times of column volume, and eluent recovery ethanol is to dry to the greatest extent, pulverizing, and it is standby to get dry extract II;

C. oral liquid preparation: the one or any combination among qinghuo reagent I, dry extract I, clear paste II, the dry extract II, add the oral liquid dissolved above-mentioned volatile oil of aromatic commonly used, make oral liquid according to the conventional preparation method of oral liquid.

Embodiment 36

B. clear paste I, the dry extract I, clear paste II, the dry extract II that get the acquisition of embodiment 35 methods are standby;

C. just clear paste I 1g, dry extract I 1g, clear paste II 1g, dry extract II 1g with, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, stirring makes dissolving, and heated and boiled 1 hour is filtered to the medicinal liquid clarification, add water to requirement, stir, put cold, to 35 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 105 ℃ of pressure sterilizings 10 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 37

B. the clear paste I, the dry extract I that get the acquisition of embodiment 35 methods are standby;

C. with clear paste I 19g, dry extract I 3g, mix homogeneously adds water, stirs, filter, again sucrose is poured into wherein, add water, stir, filter, sucrose is poured into wherein again, thin up is to requirement, and stirring makes dissolving, heated and boiled 0.5 hour is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 38

B. the clear paste II, the dry extract II that get the acquisition of embodiment 35 methods are standby;

C. with clear paste II 12g, dry extract II 28g mix homogeneously, add water, stir, filter, again sucrose is poured into wherein, added water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 2 hours is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to 20 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 125 ℃ of pressure sterilizings 25 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 39

B. the clear paste I that gets the acquisition of embodiment 35 methods is standby;

C. clear paste I 25g is added water, stir, make oral liquid.

Embodiment 40

B. the dry extract I that gets the acquisition of embodiment 35 methods is standby;

C. with dry extract I 10g, add water, stir, filter, again sucrose is poured into wherein, added water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 1 hour is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to 40 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 110 ℃ of pressure sterilizings 10 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 41

B. the clear paste II that gets the acquisition of embodiment 35 methods is standby;

C. with clear paste II 20g, add water, stir, filter, again sucrose is poured into wherein, added water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 3 hours is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to 45 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 100 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Embodiment 42

B. the dry extract II that gets the acquisition of embodiment 35 methods is standby;

C. with dry extract II 1g, add water, stir, filter, again sucrose is poured into wherein, added water, stir, filter, sucrose is poured into wherein, thin up is to requirement again, and stirring makes dissolving, heated and boiled 1 hour is filtered to the medicinal liquid clarification, adds water to requirement, stir, put cold, to below 60 ℃, filter, adding adds with the dissolved volatile oil of an amount of Tween-80, stirs; Embedding, gland, 121 ℃ of pressure sterilizings 20 minutes; Packing promptly gets the oral liquid finished product.

Claims

1. an extract oral liquid and preparation method thereof for the treatment of gastrointestinal disease is characterized in that comprising the steps:

A. get 15.50～55.80 parts of recipe quantity Ramulus Uncariae Cum Uncis, 80.40～215.50 parts of Cortex Magnoliae Officinalis, 55.50～205.80 parts of Radix Trichosanthis, 155.60～423.20 parts in Poria, 80.40～215.50 parts of the Radixs Angelicae Dahuricae, 80.40～215.50 parts of Guangdong Massa Medicata Fermentata, 15.50～55.80 parts of Fructus Tribulis, 80.40～215.50 parts of Rhizoma Atractylodis, 80.40～215.50 parts of Radix Puerariaes, 36.70～125.40 parts of Exocarpium Citri Grandises, 55.50～205.80 parts of Fructus Oryzae Germinatus, 36.70～125.40 parts of Flos Chrysanthemis, 80.40～215.50 parts of the Radix Aucklandiae, 80.40～215.50 parts of Herba Pogostemonis, 36.70～125.40 parts of Herba Menthaes, 95.20～324.80 parts of Semen Coiciss are standby;

2. treat the extract oral liquid and preparation method thereof of gastrointestinal disease according to claim 1, it is characterized in that comprising the steps:

A. it is standby to get 34.10 parts of recipe quantity Ramulus Uncariae Cum Uncis, 136.40 parts of Cortex Magnoliae Officinalis, 102.30 parts of Radix Trichosanthis, 272.80 parts in Poria, 136.40 parts of the Radixs Angelicae Dahuricae, 136.40 parts of Guangdong Massa Medicata Fermentata, 34.10 parts of Fructus Tribulis, 136.40 parts of Rhizoma Atractylodis, 136.40 parts of Radix Puerariaes, 68.20 parts of Exocarpium Citri Grandises, 102.30 parts of Fructus Oryzae Germinatus, 68.20 parts of Flos Chrysanthemis, 136.40 parts of the Radix Aucklandiae, 136.40 parts of Herba Pogostemonis, 68.20 parts of Herba Menthaes, 170.50 parts of Semen Coiciss;