CN109952305A - 哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 - Google Patents
哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 Download PDFInfo
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Gastroenterology & Hepatology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Pyridine Compounds (AREA)
Abstract
本发明涉及哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用。特别地,本发明涉及通式(I)所示的哌嗪并杂芳基类衍生物、其制备方法、含有该衍生物的药物组合物,以及其作为衣壳蛋白抑制剂,特别是在预防和/或治疗乙型肝炎、流感、疱疹和艾滋病等疾病中的用途。其中通式(I)中的各基团的定义与说明书中的定义相同。
Description
PCT国内申请,说明书已公开。
Claims (19)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017106217449 | 2017-07-27 | ||
CN201710621744 | 2017-07-27 | ||
CN201711058986 | 2017-11-01 | ||
CN2017110589868 | 2017-11-01 | ||
PCT/CN2018/097170 WO2019020070A1 (zh) | 2017-07-27 | 2018-07-26 | 哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109952305A true CN109952305A (zh) | 2019-06-28 |
CN109952305B CN109952305B (zh) | 2022-06-21 |
Family
ID=65040957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880004423.7A Active CN109952305B (zh) | 2017-07-27 | 2018-07-26 | 哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11247998B2 (zh) |
EP (1) | EP3660018A4 (zh) |
JP (1) | JP2020528062A (zh) |
KR (1) | KR20200032702A (zh) |
CN (1) | CN109952305B (zh) |
AU (1) | AU2018305614B2 (zh) |
BR (1) | BR112020001299A2 (zh) |
CA (1) | CA3070004A1 (zh) |
RU (1) | RU2745431C1 (zh) |
WO (1) | WO2019020070A1 (zh) |
ZA (1) | ZA201908609B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113039186A (zh) * | 2018-11-02 | 2021-06-25 | 艾库里斯有限及两合公司 | 抗乙型肝炎病毒HBV的脲6,7-二氢-4H-吡唑并[1,5-a]吡嗪活性剂 |
CN114146582A (zh) * | 2021-11-30 | 2022-03-08 | 南京工业大学 | 一种氟化zif-90改性pdms膜的制备方法 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR116947A1 (es) * | 2018-11-02 | 2021-06-30 | Aicuris Gmbh & Co Kg | Derivados de urea 6,7-dihidro-4h-pirazolo[1,5-a]pirazinas-indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
CN111484497B (zh) * | 2019-01-25 | 2021-07-02 | 江苏恒瑞医药股份有限公司 | 咪唑并[1,5-a]吡嗪类衍生物的可药用盐、晶型及其制备方法 |
CN111484498B (zh) * | 2019-01-25 | 2021-05-14 | 江苏恒瑞医药股份有限公司 | 咪唑并[1,5-a]吡嗪类化合物的晶型及其制备方法 |
MX2021008929A (es) * | 2019-01-25 | 2021-08-24 | Jiangsu Hengrui Medicine Co | Forma cristalina de un derivado de 1,2,3-triazolo[1,5-a]pirazinas, y metodo de preparacion para la forma de cristal. |
BR112021021564A2 (pt) | 2019-04-30 | 2022-01-04 | Aicuris Gmbh & Co Kg | Indol-2-carboxamidas inovadoras ativas contra o vírus da hepatite b (hbv) |
JP2022533008A (ja) | 2019-04-30 | 2022-07-21 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | B型肝炎ウイルス(hbv)に対し活性な新規のオキサリルピペラジン |
WO2020221824A1 (en) | 2019-04-30 | 2020-11-05 | Aicuris Gmbh & Co. Kg | Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv) |
JP2022531199A (ja) | 2019-04-30 | 2022-07-06 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | B型肝炎ウイルス(hbv)に対し活性な新規のフェニル及びピリジル尿素 |
CN112778299B (zh) * | 2019-11-04 | 2023-07-14 | 江苏恒瑞医药股份有限公司 | 哌嗪脲基类衍生物、其制备方法及其在医药上的应用 |
WO2022022613A1 (zh) * | 2020-07-29 | 2022-02-03 | 江苏恒瑞医药股份有限公司 | 一种三氮唑并[1,5-a]吡嗪制备方法及其应用 |
CN114057745A (zh) * | 2020-07-29 | 2022-02-18 | 江苏恒瑞医药股份有限公司 | 一种三氮唑并[1,5-a]吡嗪制备方法及其应用 |
EP4229062A1 (en) | 2020-10-15 | 2023-08-23 | Aligos Therapeutics, Inc. | Bicyclic compounds |
TW202245772A (zh) * | 2021-02-04 | 2022-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種衣殼蛋白抑制劑的醫藥組成物及其製備方法 |
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CN100391958C (zh) * | 2001-09-19 | 2008-06-04 | 安万特医药股份有限公司 | 化合物 |
CN101686989A (zh) * | 2007-06-21 | 2010-03-31 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
CN103168041A (zh) * | 2010-06-03 | 2013-06-19 | 赛诺菲 | 3,4-二氢吡咯并[1,2-a]吡嗪-2,8(1h)-二甲酰胺衍生物、其制备方法及其治疗用途 |
WO2016113273A1 (en) * | 2015-01-16 | 2016-07-21 | F. Hoffmann-La Roche Ag | Pyrazine compounds for the treatment of infectious diseases |
CN105916855A (zh) * | 2013-11-14 | 2016-08-31 | 百时美施贵宝公司 | 作为酪蛋白激酶1d/e抑制剂的取代的4,5,6,7-四氢吡唑并[1,5-a]吡嗪衍生物 |
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-
2018
- 2018-07-26 AU AU2018305614A patent/AU2018305614B2/en not_active Ceased
- 2018-07-26 KR KR1020207003425A patent/KR20200032702A/ko unknown
- 2018-07-26 JP JP2020502945A patent/JP2020528062A/ja active Pending
- 2018-07-26 EP EP18837963.0A patent/EP3660018A4/en not_active Withdrawn
- 2018-07-26 BR BR112020001299-8A patent/BR112020001299A2/pt not_active Application Discontinuation
- 2018-07-26 WO PCT/CN2018/097170 patent/WO2019020070A1/zh unknown
- 2018-07-26 CA CA3070004A patent/CA3070004A1/en active Pending
- 2018-07-26 CN CN201880004423.7A patent/CN109952305B/zh active Active
- 2018-07-26 RU RU2020105275A patent/RU2745431C1/ru active
- 2018-07-26 US US16/632,973 patent/US11247998B2/en active Active
-
2019
- 2019-12-23 ZA ZA2019/08609A patent/ZA201908609B/en unknown
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CN100391958C (zh) * | 2001-09-19 | 2008-06-04 | 安万特医药股份有限公司 | 化合物 |
CN101686989A (zh) * | 2007-06-21 | 2010-03-31 | 卡拉治疗学股份有限公司 | 取代的咪唑并杂环 |
CN103168041A (zh) * | 2010-06-03 | 2013-06-19 | 赛诺菲 | 3,4-二氢吡咯并[1,2-a]吡嗪-2,8(1h)-二甲酰胺衍生物、其制备方法及其治疗用途 |
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Non-Patent Citations (1)
Title |
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PUBCHEM: "PubChem CID 90793128", 《PUBCHEM》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113039186A (zh) * | 2018-11-02 | 2021-06-25 | 艾库里斯有限及两合公司 | 抗乙型肝炎病毒HBV的脲6,7-二氢-4H-吡唑并[1,5-a]吡嗪活性剂 |
CN114146582A (zh) * | 2021-11-30 | 2022-03-08 | 南京工业大学 | 一种氟化zif-90改性pdms膜的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
AU2018305614B2 (en) | 2022-05-12 |
US20200157111A1 (en) | 2020-05-21 |
BR112020001299A2 (pt) | 2020-07-28 |
US11247998B2 (en) | 2022-02-15 |
CA3070004A1 (en) | 2019-01-31 |
JP2020528062A (ja) | 2020-09-17 |
RU2745431C1 (ru) | 2021-03-25 |
EP3660018A1 (en) | 2020-06-03 |
CN109952305B (zh) | 2022-06-21 |
WO2019020070A1 (zh) | 2019-01-31 |
AU2018305614A1 (en) | 2020-03-05 |
ZA201908609B (en) | 2022-07-27 |
EP3660018A4 (en) | 2021-04-21 |
KR20200032702A (ko) | 2020-03-26 |
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