CN109856098B - Enhanced fluorescent quantitative analyzer - Google Patents
Enhanced fluorescent quantitative analyzer Download PDFInfo
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- CN109856098B CN109856098B CN201910097108.XA CN201910097108A CN109856098B CN 109856098 B CN109856098 B CN 109856098B CN 201910097108 A CN201910097108 A CN 201910097108A CN 109856098 B CN109856098 B CN 109856098B
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Abstract
The invention discloses an enhanced fluorescence quantitative analyzer, and mainly relates to the field of in-vitro diagnostic equipment. The utility model discloses a portable electronic device, including a housin, a display module, a control panel, the sample test module, power module, print the module, casing top surface mid-mounting detection module, display module installs at the casing front end, the sample test module sets up at the casing middle part, the sample test module includes the shading base, shading epitheca and sample dish, the shading shell includes shading epitheca and shading base, the sample dish rotates with the shading base to be connected, the sample dish rotates with the transmission shaft to be connected, shading epitheca cover is in the sample dish outside, the shading epitheca is provided with at the front end of top surface and places the mouth, be provided with a plurality of sample holes along the circumferencial direction on the sample dish, the sample pipe is equipped with in the sample hole, be equipped with the light source piece at the outside at the sample dish at the rear portion on the shading base, be provided with the detection piece at the back on the shading base and at the sample dish bottom. The invention has the beneficial effects that: the multi-sample detection is completed by one excitation light source and one light sensing probe.
Description
Technical Field
The invention relates to the field of in-vitro diagnosis equipment, in particular to an enhanced fluorescence quantitative analyzer.
Background
The immunoassay method for marking antigen or antibody by fluorescent marker in vitro diagnosis comprises irradiating light to a target, emitting weak fluorescence outwards by the fluorescent marker, judging whether the target exists by detecting the intensity of the fluorescence, emitting light by the same excitation light source to be conducted by optical fibers in most of the existing equipment, and arranging a plurality of light-sensing probes in the detection process, so that the variable among samples in the detection process is large, and the stability and the accuracy in the detection of a plurality of samples are influenced to a certain extent.
Disclosure of Invention
The invention aims to provide an enhanced fluorescence quantitative analyzer which completes multi-sample detection work through an excitation light source and a light-sensitive probe.
In order to achieve the purpose, the invention is realized by the following technical scheme: enhanced fluorescent quantitative analyzer
Comprises a shell, a display module, a control panel, a sample detection module,
The power module and the printing module are arranged on the middle part of the top surface of the shell, the display module is arranged on the shell
A front end of the housing, the display
An operation lamp is arranged below the display module, an interface board is arranged at the rear part of the shell, a switch power supply of equipment is arranged at one side of the shell close to the display module,
the thermal printer is arranged on one side of the shell, the shell is provided with air vents on both sides and the rear part,
the sample detection module is arranged in the middle of the shell, the control panel is arranged on two sides of the sample detection module in the shell, and the power module is arranged below the sample detection module and used for detecting samples
The module provides power
The power module comprises a servo motor and a transmission shaft, the servo motor is coaxially and fixedly connected with the transmission shaft, the private motor and the transmission shaft are arranged in the vertical direction,
the sample detection module comprises a shading base, a shading upper shell and a sample plate, the shading outer shell comprises a shading upper shell and a shading base, the sample plate is rotatably connected with the shading base, the sample plate is rotatably connected with a transmission shaft, the shading upper shell covers the outer side of the sample plate, a placing opening is formed in the front end of the top surface of the shading upper shell, a plurality of sample holes are formed in the sample plate along the circumferential direction, the sample holes are blind holes with upward openings and square structures, and sample tubes are arranged in the sample holes,
the light shading base is provided with a light source block at the rear part and on the outer side of the sample plate, and the light shading base is provided with a detection block at the rear part and at the bottom of the sample plate. The sample hole is close to the plane of the axial line position of the sample disc
The faces are arranged perpendicular to the radial direction of the sample disk, the
The sample hole side is provided with logical unthreaded hole, it runs through the sample dish along sample dish radial direction to lead to the unthreaded hole, lead to the recess of unthreaded hole UNICOM sample dish outside sample hole and sample dish bottom.
The cross section of the sample tube is square, the bottom of the sample tube is of a hollow rectangular pyramid structure, and the upper part of the sample tube is of a square tube structure.
The sample tube is sleeved with a support frame, the support frame is of a square tubular structure in the vertical direction, the support frame and the sample tube are coaxially arranged, and the bottom of the support frame is provided with a light through groove.
The sample tube is equipped with the fixed tenon in one side on upper portion, the fixed tenon cross-section is the T type structure of vertical direction, one side on support frame upper portion is provided with the T type groove and the inside UNICOM of support frame of vertical direction, T type groove is used for cooperating with the fixed tenon, the top surface UNICOM of T type groove and support frame.
And guide parts are arranged on two sides of the bottom end of the fixing tenon. The top of the support frame is provided with a grab handle perpendicular to the top surface
. The top end of the grab handle is provided with a blocking sheet perpendicular to the grab handle, and the blocking sheet is arranged on the grab handle and is far away from the support
Support
One side of the inner hole of the frame.
The light source block is provided with light source holes, the axes of the light source holes are perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube, and one ends, far away from the sample plate, of the light source holes are provided with light sources.
The detection block is provided with a detection hole, the axis of the detection hole is perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube, and one end, far away from the sample plate, of the detection hole is connected with a photon counter through an optical fiber.
Compared with the prior art, the invention has the beneficial effects that: accomplish many sample detection work through an excitation light source and light sense probe and pivoted sample dish, the sample dish is rotating-structure, excitation light source and light sense probe for the sample dish is fixed to accomplish the detection of each sample on the sample dish through the sample dish rotation, because the sample dish is rotating-structure, put into the mouth and detect the position and can realize the mobile sample loading work of equipment far away, can put into the sample when using while carrying out sample detection, improve the efficiency of inspection.
Drawings
FIG. 1 is a perspective view in front elevation of the present invention.
Fig. 2 is a perspective view of the present invention in a rear view.
Fig. 3 is a structural sectional view of the present invention.
Fig. 4 is a sectional view showing an assembled state of a transmission shaft, a sample tray, a sample tube, a support frame and a light-shielding base according to the present invention.
Fig. 5 is an assembled perspective view of the drive shaft, sample tray, sample tube, support frame and light source block of the present invention.
Fig. 6 is an exploded view of the assembly of the drive shaft, sample tray, sample tube, support frame and light source block of the present invention.
Reference numerals shown in the drawings: 1. a housing; 2. a display module; 3. a control panel; 4. sample detection module
(ii) a 5. A printing module; 6.
a servo motor; 7. a drive shaft; 8. a light-shielding base; 9. a light-shielding upper shell; 10. a sample tray; 11. a placement port; 12. a sample well; 13. a light through hole; 14. a light source block; 15. a detection block; 16. a sample tube; 17. fixing the tenon; 18. a support frame; 19. a T-shaped groove; 20. a light-transmitting groove; 21. a handle.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and these equivalents also fall within the scope of the present application.
Example (b): an enhanced fluorescence quantitative analyzer comprises a shell, a display module 2, a control panel 3, a sample detection module 4, a power module and a printing module 5, wherein the display module 2 is arranged at the front end of the shell, the shell is of an upper and lower split structure, a hole for installing the detection module is arranged in the middle of the upper half part of the shell, an interface board is arranged at the rear part of the shell, a power port USB port net port is arranged on the interface board for data transmission, the display module 2 is a touch display integrated liquid crystal screen, three operation lamps are arranged below the display module 2 and are sequentially and respectively a power indicator lamp, a starting indicator lamp and a detection indicator lamp, a switching power supply of equipment is arranged at one side of the shell close to the display module 2, a thermal printer is arranged at the position close to the rear of one side of the shell provided with the switching power supply, and the shell is provided with ventilation openings at both sides and the rear part, the vent inboard is provided with the supplementary circulation of air of axial-flow fan, sample detection module 4 sets up at the casing middle part, control panel 3 sets up and sets up in the inside sample detection module 4's of casing both sides, power module sets up in the below of sample detection module 4, provides power for sample detection module 4, power module includes servo motor 6 and transmission shaft 7, servo motor 6 and the coaxial fixed connection of transmission shaft 7, suit of private motor and the 7 vertical directions of transmission shaft arrange, transmission shaft 7 rotates through antifriction bearing and shading base 8 and is connected.
The sample detection module 4 comprises a bottom shading base 8, a shading upper shell 9 and a sample disc 10, wherein the sample disc 10 is rotatably connected with the shading base 8, the sample disc 10 is rotatably connected with the transmission shaft 7, the shading upper shell 9 covers the outer side of the sample disc 10, and a placing opening 11 is formed in the front end of the top surface of the shading upper shell 9.
The bottom of the sample disc 10 is provided with a circular concave platform, eighteen sample holes 12 are arranged on the sample disc 10 along the circumferential direction, the sample holes 12 are blind holes with upward openings and square structures, the planes of the sample holes 12 close to the axial line position of the sample disc 10 are arranged in the radial direction of the sample disc 10, the side surfaces of the sample holes 12 close to the bottom are provided with light through holes 13, the light through holes 13 penetrate through the sample disc 10 along the radial direction of the sample disc 10, the light through holes 13 communicate with the sample holes 12 on the outer side of the sample disc 10 and the grooves at the bottom of the sample disc 10,
the light shading base 8 is provided with a light source block 14 at the rear part and at the position corresponding to the light through hole 13 on the outer side of the sample disc 10, the surface of one side, close to the sample disc 10, of the light source block 14 is a circumferential surface matched with the circumferential surface on the outer side of the sample disc 10, the detection block 15 is provided with a light source hole, the axis of the light source hole is perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube 16, and a light source is installed at one end, far away from the sample disc 10, of the light source hole.
A detection block 15 at the position corresponding to the light through hole 13 is arranged on the rear part of the shading base 8 and on the inner side of a circular concave table at the bottom of the sample plate 10, the surface of one side, close to the sample plate 10, of the detection block 15 is a circumferential surface matched with the circumferential surface of the inner side of the sample plate 10 in a facing manner, a detection hole is arranged on the detection block 15, the axis of the detection hole is perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube 16, one end, far away from the sample plate 10, of the detection hole is connected with a photon counter through an optical fiber,
accomplish many sample detection work through an excitation light source and light sense probe and pivoted sample dish 10, sample dish 10 is rotating-structure, excitation light source and light sense probe are fixed for sample dish 10 and rotate the detection of accomplishing each sample on the sample dish 10 through sample dish 10, because sample dish 10 is rotating-structure, put into the mouth and detect the position far away and can realize the flow of equipment and go up the appearance work, can put into the sample when using and carry out sample detection, improve the efficiency of inspection.
In order to reduce the reagent consumption, a conical structure is used, the influence of curvature change of a traditional conical micro-measuring cup on refraction is large, the section of the sample tube 16 is square, the bottom of the sample tube 16 is of a hollow rectangular pyramid structure, the upper part of the sample tube 16 is of a square tube structure, one side of the upper part of the sample tube 16 is provided with a fixing tenon 17, the fixing tenon 17 comprises a connecting plate and a fixing plate, the fixing plate is parallel to one side surface of the upper part of the sample tube 16, the fixing plate is connected with the outer side of the upper part of the sample tube 16 through the connecting plate, the bottom end of the fixing plate, far away from the two sides of the connecting plate, is provided with a guide part, the guide part is of an inclined plane structure forming an angle of 45 degrees with the connecting plate, the section of the fixing tenon 17 is of a T-shaped structure, the pyramid structure enables an irradiation surface to be a plane, the surface receiving light emission is also of a plane structure, loss caused by refraction is reduced, and accordingly the accuracy of the device on the light emission of the sample is improved,
in order to reduce the pollution to the outer wall of the sample tube 16, a support frame 18 is sleeved outside the sample tube 16, the support frame 18 is of a square tubular structure in the vertical direction, the support frame 18 and the sample tube 16 are coaxially arranged, the size of an inner hole of the support frame 18 is the same as the size of the section of the upper portion of the sample tube 16, a T-shaped groove 19 in the vertical direction is formed in one side of the upper portion of the support frame 18 and communicated with the inside of the support frame 18, the T-shaped groove 19 is used for being matched with a fixing plate and a connecting plate on the sample tube 16, the T-shaped groove 19 is communicated with the top surface of the support frame 18, the depth of the T-shaped groove 19 is the same as the height of the fixing plate, when the sample tube 16 is arranged in the support frame 18, the top surface of the sample tube 16 is flush with the top surface of the support frame 18,
in order to enable the excitation light and the emitted fluorescence to be detected, the supporting frame 18 is provided with a light-passing groove 20 at the bottom, the light-passing groove 20 penetrates through the whole side wall structure of the supporting frame 18, and the penetrating direction of the light-passing groove 20 is perpendicular to the side face of the supporting frame 18 provided with the T-shaped groove 19.
In order to take the sample tube 16 out of the sample tray 10 conveniently, the top of the support frame 18 is provided with a handle 21 perpendicular to the top surface, the handle 21 is arranged at a position close to the outer side of the support frame 18 on one side provided with the T-shaped groove 19, and in order to facilitate grasping, the top end of the handle 21 is provided with a blocking piece perpendicular to the handle 21, and the blocking piece is arranged on one side of the handle 21 away from the inner hole of the support frame 18.
When the support frame 18 is used, one end with the handle 21 of the support frame is arranged close to the middle of the sample plate 10, and the light-transmitting groove 20 is in the same direction with the light-transmitting hole 13, so that light cannot be blocked from being transmitted from the inner side to the outer side of the sample plate 10.
Claims (7)
1. The enhancement mode fluorescence quantitative analysis appearance, its characterized in that: comprises a shell (1), a display module (2), a control panel (3), a sample detection module (4), a power module and a printing module (5),
a detection module is arranged in the middle of the top surface of the shell (1), the display module (2) is arranged at the front end of the shell (1), an operation lamp is arranged below the display module (2), an interface board is arranged at the rear part of the shell (1), a switching power supply of equipment is arranged at one side of the shell (1) close to the display module (2),
the printing module (5) is arranged on one side of the shell (1), the shell (1) is provided with ventilation openings on both sides and the rear part,
the sample detection module (4) is arranged in the middle of the shell (1), the control panel (3) is arranged at two sides of the sample detection module (4) in the shell (1),
the power module is arranged below the sample detection module (4) and provides power for the sample detection module (4), the power module comprises a servo motor (6) and a transmission shaft (7), the servo motor (6) is coaxially and fixedly connected with the transmission shaft (7), the servo motor and the transmission shaft (7) are arranged in the vertical direction,
the sample detection module (4) comprises a shading base (8), a shading upper shell (9) and a sample disc (10), the shading shell comprises the shading upper shell (9) and the shading base (8), the sample disc (10) is rotatably connected with a transmission shaft (7), the shading upper shell (9) covers the outer side of the sample disc (10), a placing opening (11) is formed in the front end of the top surface of the shading upper shell (9), a plurality of sample holes (12) are formed in the sample disc (10) along the circumferential direction, the sample holes (12) are blind holes with upward openings and square structures, a sample tube (16) is arranged in each sample hole (12), a light source block (14) is arranged on the shading base (8) at the rear part and on the outer side of the sample disc (10), a detection block (15) is arranged on the shading base (8) at the rear part and at the bottom of the sample disc (10), the cross section of the sample tube (16) is square, the bottom of the sample tube (16) is of a hollow rectangular pyramid structure, the upper portion of the sample tube (16) is of a square tube structure, a support frame (18) is sleeved outside the sample tube (16), the support frame (18) is of a square tubular structure in the vertical direction, the support frame (18) and the sample tube (16) are arranged coaxially, a light through groove (20) is formed in the bottom of the support frame (18), a fixing tenon (17) is arranged on one side of the upper portion of the sample tube (16), the cross section of the fixing tenon (17) is of a T-shaped structure in the vertical direction, a T-shaped groove (19) in the vertical direction is formed in one side of the upper portion of the support frame (18) and communicated with the inside of the support frame (18), the T-shaped groove (19) is used for being matched with the fixing tenon (17), and the T-shaped groove (19) is communicated with the top surface of the support frame (18).
2. The enhanced fluorescence quantitative analyzer of claim 1, wherein: the plane that sample hole (12) are close to sample dish (10) axis position is perpendicular to sample dish (10) radial direction and arranges, sample hole (12) side is provided with logical unthreaded hole (13), logical unthreaded hole (13) run through sample dish (10) along sample dish (10) radial direction, logical unthreaded hole (13) UNICOM sample dish (10) outside sample hole (12) and the recess of sample dish (10) bottom.
3. The enhanced fluorescence quantitative analyzer of claim 1, wherein: and guide parts are arranged on two sides of the bottom end of the fixing tenon (17).
4. The enhanced fluorescence quantitative analyzer of claim 1, wherein: the top of the support frame (18) is provided with a grab handle (21) which is vertical to the top surface.
5. The enhanced fluorescence quantitative analyzer of claim 4, wherein: the top end of the grab handle (21) is provided with a blocking sheet perpendicular to the grab handle (21), and the blocking sheet is arranged on one side of the grab handle (21) far away from the inner hole of the support frame (18).
6. The enhanced fluorescence quantitative analyzer according to any one of claims 1 to 5, wherein: the light source block (14) is provided with light source holes, the axes of the light source holes are perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube (16), and one ends, far away from the sample plate (10), of the light source holes are provided with light sources.
7. The enhanced fluorescence quantitative analyzer according to any one of claims 1 to 5, wherein: the detection block (15) is provided with a detection hole, the axis of the detection hole is perpendicular to the surface of the rectangular pyramid structure at the bottom of the sample tube (16), and one end, far away from the sample plate (10), of the detection hole is connected with a photon counter through an optical fiber.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910097108.XA CN109856098B (en) | 2019-01-31 | 2019-01-31 | Enhanced fluorescent quantitative analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910097108.XA CN109856098B (en) | 2019-01-31 | 2019-01-31 | Enhanced fluorescent quantitative analyzer |
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| CN109856098A CN109856098A (en) | 2019-06-07 |
| CN109856098B true CN109856098B (en) | 2021-08-20 |
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