CN109833381A - A kind of pure plant drug composition improving sleep - Google Patents
A kind of pure plant drug composition improving sleep Download PDFInfo
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- CN109833381A CN109833381A CN201910306735.XA CN201910306735A CN109833381A CN 109833381 A CN109833381 A CN 109833381A CN 201910306735 A CN201910306735 A CN 201910306735A CN 109833381 A CN109833381 A CN 109833381A
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Abstract
The invention discloses a kind of pure plant drug compositions for improving sleep, consist of the following components in percentage by weight: Wild jujube seeds extract 32-42%；Valerian root P.E 24-34%；Ginkgo biloba extract 15-22%；5HTP 15-22%.Reasonably optimizing formula of the present invention, using natural plant extracts, having improves sleep, tranquilizing the mind and other effects of calming.Plant drug composition of the invention can help quickly to fall asleep and sleep all night, can allow sleep deeper into, it is more quiet and comfortable, spirit and QI cleaning after waking up for second day, no giddy is drowsiness, blunt equal ill effects.It can be effectively relieved and treat the sleep disturbance as caused by neurasthenia, depressive anxiety, confused and worried etc. or palpitation and insomnia, and it has no toxic and side effect to human body and without drug dependence, it is a kind of plant drug composition of efficient, safety treatment of insomnia patients, is better than existing traditional Chinese medicine preparation product.
Description
Technical field
The present invention relates to health medicine technical field, specially a kind of pure plant drug composition for improving sleep.
Background technique
With social development tempo increase and increasingly competitive, all striven so as to cause insomnia, anxiety person with day.According to system
It counts, the insomnia rate in European and American developed countries crowd reaches 15-30%, and China insomniac is also in rising trend in recent years, there is investigation number
According to display, there is sleep disturbance more than 300,000,000 Chinese, adult's insomnia incidence is up to 38.2%.Insomnia be due to mind dystrophy or
It is confused and worried and cause often obtain a kind of illness that ortho is characterized, it is mainly shown as that sleeping time is insufficient, sleeps
Dormancy depth is inadequate, cannot eliminate fatigue, cannot regain one's strength and energy.Since the deficiency of sleeping time or sleep are not yet done, after waking up
Common spiritlessness and weakness, dizziness headache, palpitation and amnesia and the symptoms such as have no peace of mind.Scientific research is, it was also found that sleep insufficiency will lead to
Memory is decreased obviously, malnutritive, atrophy or even apoptosis, the direct phase of generation with cardiovascular and cerebrovascular diseases with neuronal cell
It closes.
Treatment insomnia at present is mainly based on synthetic drug, and western medicine insomnia is mainly using calm, hypnotic drug.But
That, though this kind of drug is curative for effect, can become effective in short term, its side effect is larger, such as have a dizzy spell, be out of strength, influence memory,
Drug dependence is easily caused, thus it is very necessary to find the natural plant that can improve and sleep.
Compared with Western medicine, Chinese medicine has higher safety.But Chinese patent drug currently on the market some contain calm tranquilizing the mind
Minerals medicine cinnabar, certain injury can be caused to human body, some contain the vine of multiflower knotweed, be used for a long time, contained by Anthraquinones
Compound will cause serious hepatic injury.
Summary of the invention
The purpose of the present invention is to provide a kind of pure plant drug compositions for improving sleep, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the invention provides the following technical scheme: a kind of pure plant medicine combination for improving sleep
Object consists of the following components in percentage by weight:
Wild jujube seeds extract 32-42%；
Valerian root P.E 24-34%；
Ginkgo biloba extract 15-22%；
5HTP 15-22%.
Preferably, the effective component of the Wild jujube seeds extract is jujuboside, wherein the content of jujuboside
Not less than 10%.
Preferably, the effective component of the Valerian root P.E is valeric acid, and wherein the content of valeric acid is not less than 0.8%.
Preferably, the effective component of the ginkgo biloba extract is GINKGO BILOBA EXTRACT and ginkgolides, and wherein GINKGO BILOBA EXTRACT contains
Amount is not less than 24%, and ginkgolides content is not less than 6%.
Preferably, the 5HTP is Ghana's seed extract, the purity of 5HTP at least 99%.
Preferably, the natural plants drug composition of the improvement sleep, it is characterised in that: the dosage form of the composition medicine
It is tablet, wafer, granule, lozenge.
Preferably, the natural plants drug composition is made with pharmaceutically acceptable carrier, the acceptable load
Body can be one of diluent, lubricant, adhesive, disintegrating agent, sweetener, stabilizer, preservative etc. or more than one
Mixture.
Raw material used in formula in the present invention is natural plant composition, and extract is existed with powder form, is led to
Cross 80 meshes.
The dosage form of the natural plants drug composition of improvement sleep of the invention is tablet, pill, granule, capsule.Clothes
Dosage is adult 2*300 milligrams daily, takes orally, takes within 30-60 minutes before sleeping.
Wild jujube seeds extract has calmness, syngignoscism, mental-tranquilization.Modern research shows why semen ziziphi spinosae can have
The effect of mental-tranquilization is because of its sleep stage that can influence slow wave sleep, to extend the sound sleep time.From European valerian
The valerian diluted acid substance of middle extraction, can the effectively secretion of inducing neural peptide S, shorten the process of activation homoreceptor (NPSR),
Cause intracellular Ca rapidly2+Activity restores active sleep and eliminates depression and anxiety, can shorten time for falling asleep, improve sleep
It is deep, it is refreshed after wakeing up, without apparent early morning hangover effect.Ginkgo biloba extract has the nervous anxiety for the treatment of, balance
Inhibiting effect.5HTP is the precursor substance of human serum element, this hormone of total balance of the body can be helped, to control
Human body mood processed improves sleep quality.
Compared with prior art, the beneficial effects of the present invention are: reasonably optimizing formula of the present invention, using extracted form natural plant
Object, having improves sleep, tranquilizing the mind and other effects of calming.Plant drug composition of the invention can help quickly to fall asleep and sleep whole night
Sleep, can allow sleep deeper into, it is more quiet and comfortable, spirit and QI cleaning after waking up for second day, no giddy is drowsiness, blunt equal ill effects.It can
It is effectively relieved and treats the sleep disturbance as caused by neurasthenia, depressive anxiety, confused and worried etc. or palpitation and insomnia, and to people
Body has no toxic side effect and is a kind of plant drug composition of efficient, safety treatment of insomnia patients, better than existing without drug dependence
Traditional Chinese medicine preparation product.
The pharmacological property of drug in inventive formulation is as follows:
Semen ziziphi spinosae: semen ziziphi spinosae is Chinese medicine, is recorded in Shennong's Herbal for the first time, is the heart-nourishing tranquilizer of sedative in Chinese medicine
It is a kind of.Mental-tranquilization, can be used for palpitation and insomnia, can nourishing heart yin, invigorating heart liver blood and have the effect of tranquilizing the mind.
Valerian: in traditional Chinese medicine, using valerian root and rhizome is the drug of mental-tranquilization in sedative as medicinal.Figured silk fabrics
The pharmacological property of grass is pungent, sweet, warm, converge to heart and liver channels.There is the effect of mental-tranquilization, qi-regulating, promoting blood circulation and stopping pain.Valerian makees in traditional Chinese medicine
For sedative use, valerian is the active drug for the treatment of insomnia at present.
Ginkgo: ginkgo biloba extract refers to the active principle extracted from ginkgo, contains GINKGO BILOBA EXTRACT, the objects such as ginkgolides
Matter.Have an expansion blood vessel, protection vascular endothelial tissue, adjust blood lipid, protection low-density lipoprotein, inhibit PAF(platelet activation because
Son), inhibition thrombosis removes the effects of free radical.Ginkgo biloba extract has the nervous anxiety for the treatment of, balances inhibiting effect.
The 5HTP extracted from Ghana's seed, is a kind of amino acids substance.It can be used as 5- hydroxyl color in human body
The precursor substance of amine, therefore be believed to be helpful in and improve serotonin level.Help due to thrombocytin to sleep, thrombocytin
Precursor tryptophan and 5-hydroxyryptophan can help hypophypnosis obstacle.Their prodrug its main body can pass through blood-brain barrier with
Receive and be metabolised to thrombocytin.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of pure plant drug composition improving sleep, consists of the following components in percentage by weight:
Wild jujube seeds extract 32-42%；
Valerian root P.E 24-34%；
Ginkgo biloba extract 15-22%；
5HTP 15-22%.
Technique preparation step is as follows:
Above-mentioned powdered extract raw material ultraviolet disinfection, crosses 80 meshes, then extracting screen underflow uses trough type mixing machine by powder
Material is stirred, and gained mixed powder adds wetting agent (ethyl alcohol), disintegrating agent (starch agent), adhesive (cane sugar powder) that softwood is made,
Then oscillating granulator is added, required particle is made in moist powder, add Fluidbedgranulatingdrier wet grain is dry
Whole grain controls midbody particle moisture 3%.Mixing particle stiffened fatty acid magnesium after gained is dry make lubricant (additional amount:
0.5%), to increase material fluidity, V-type high efficient mixer mixed material is added, then uses rotary tablet machine by particle
Various shape tablet is made in shape material, tabletting, and slice weight is determined at 500 milligrams, and control tablet weight variation is after coated ± 10%
Product is made.
Embodiment 2
A kind of pure plant drug composition improving sleep, consists of the following components in percentage by weight:
Wild jujube seeds extract (10% 30:1 of jujuboside), 32-42%
Valerian root P.E (valeric acid 0.8%), 24-34%
Ginkgo biloba extract (GINKGO BILOBA EXTRACT 24%, ginkgolides 6%), 15-22%
5HTP (Ghana's seed extract, 99%), 15-22%
Technique preparation step is as follows:
By mentioned component drying, ultraviolet disinfection, 80 meshes are crossed, then extracting screen underflow uses trough type mixing machine by granular material
It is stirred, auxiliary material magnesium stearate lubricant is added (additional amount: 0.5%), to increase mixing mobility, to be uniformly mixed.Then by powder
The capsule that every quality of production is 300 milligrams in capsule filling machine is added in shape mixture material, and control capsule content uniformity exists
±10%。
Embodiment 3
The clinical test of botanical medicine composite preparation of the present invention
1) diagnostic criteria
Insomnia (Latin language: Insomnia) is that one kind is not easy to naturally enter dormant symptom.It may be to be not easy to fall asleep
(having difficulty in going to sleep), or be difficult to maintain the deep sleep (being difficult to maintain to sleep) of long period.Insomnia generally can be along with daytime
The symptoms such as listless, drowsiness, irritability or depression.Insomnia may will increase the unexpected risk of traffic accident, it is also possible to people be allowed to infuse
Meaning power is not concentrated, the easy tired out and learning effect that works is bad.Insomnia may be it is short-term, take several days by one week, it is also possible to
Long-term, continue one month or more.
It is write in mental disease diagnostic & statistical manual the 5th edition (DSM-5), the diagnostic criteria of insomnia is as follows:
It has difficulty in going to sleep；
Sleep is difficult to maintain, often sleep half wake up suddenly or once waking up once be difficult to sleep again;
It rises with the sun very much, and is difficult to fall asleep again;
Insomnia already lead to melancholy clinically, social function damage, occupational function damage, education, school work, behavior and its
The difficulty in his field;
Insomnia not caused by other sleeping disorders (such as: Narcolepsy disease, sleep disturbance-relevant to breathing are slept
Dormancy Apnea disease, Circadian rhythm sleep obstacle, parasomnias etc.);
Insomnia is not as caused by substance migration, such as: drug or substance abuse;
Insomnia is not as caused by other mental diseases or disease.
2) criterion of therapeutical effect
Cure: insomnia disappears, and time for falling asleep and sleeping time are normal, i.e., fall asleep in 1 hour, whole
Sleeping time at night is more than 5 hours.
Effective: insomnia makes moderate progress, and time for falling asleep and sleeping time are normal.
Invalid: for insomnia without significant change, time for falling asleep and sleeping time are abnormal.
3) treatment method
It is insomniac 200 that inventor collects after diagnosing, is randomly divided into treatment group 100 and control group 100, treatment
Group male 40, female 60, the age 20-60 years old, course of disease 1-6；Control group male 50, female 50, the age 23-59 years old, course of disease 1-
6 years.Two groups of genders, age and course of disease comparing difference are not statistically significant, have comparativity.
The oral present invention for the treatment of group sleeps preceding 1 hour warm water every night and swallows 1 according to capsule made from specific embodiment 2
Capsule (300mg/), 10 days courses for the treatment of.Blank control group takes blank Cebo-Caps, and usage and dosage is identical as treatment group.
4) treatment results
Table 1: insomnia improves clinical trials condition
The average time for falling asleep for the treatment of group is 30 minutes, and the average time for falling asleep of blank control group is 90 minutes, and treatment group puts down
Equal sleeping time is 8.0 hours, and blank control group is averaged sleeping time 4.0 hours.Wherein the clinical symptoms for the treatment of group patient have
It is apparent to improve, it is curative for effect.
The insomnia clinical symptoms for the treatment of group patient improve significantly as shown in Table 1, show as significant therapeutic efficiency.Poison
Result is observed in side effect: in the patient treated, any adverse reaction is occurred without 1 patient, is illustrated botanical medicine group of the present invention
Closing object is safe to human body.Above-mentioned clinical observation result shows that plant drug composition of the invention sleeps to improvement and treatment is lost
Dormancy symptom is significant in efficacy, has no toxic side effect, no drug dependence.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (9)
1. a kind of pure plant drug composition for improving sleep, which is characterized in that consist of the following components in percentage by weight:
Wild jujube seeds extract 32-42%；
Valerian root P.E 24-34%；
Ginkgo biloba extract 15-22%；
5HTP 15-22%.
2. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the acid
The effective component of jujube kernel extract is jujuboside, and wherein the content of jujuboside is not less than 10%.
3. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the figured silk fabrics
The effective component of careless extract is valeric acid, and wherein the content of valeric acid is not less than 0.8%.
4. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the silver
The effective component of apricot extract is GINKGO BILOBA EXTRACT and ginkgolides, and wherein flavonoid of ginkgo biloba is not less than 24%, ginkgolides content
Not less than 6%.
5. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the 5-
Hydroxytryptophan is Ghana's seed extract, the purity of 5HTP at least 99%.
6. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that described changes
The natural plants drug composition of kind sleep, it is characterised in that: the dosage form of the composition medicine is tablet, wafer, granule, contains
Piece.
7. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the day
Right plant drug composition is made with pharmaceutically acceptable carrier, and the acceptable carrier can be diluent, lubricant, glue
One of mixture, disintegrating agent, sweetener, stabilizer, preservative etc. or more than one mixture.
8. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the day
Raw material used in right plant drug composition is natural plant composition, and extract is existed with powder form, and 80 mesh are passed through
Sieve.
9. a kind of pure plant drug composition for improving sleep according to claim 1, which is characterized in that the day
The dosage form of right plant drug composition is tablet, pill, granule, capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464711A (en) * | 2019-09-04 | 2019-11-19 | 西安科力康医药科技有限公司 | A kind of 5 hydroxytryptophan slow-release tablet preparation methods |
| CN111053238A (en) * | 2019-12-30 | 2020-04-24 | 广州市中食科康保健食品有限公司 | Functional food with functions of relieving pressure and helping sleep and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229247A (en) * | 2007-12-28 | 2008-07-30 | 重庆工学院 | Medicine preparation for treating insomnia and preparing method thereof |
| CN106692751A (en) * | 2016-12-29 | 2017-05-24 | 北京康比特体育科技股份有限公司 | Composition for improving exercise-induced insomnia |
| CN109528782A (en) * | 2018-12-30 | 2019-03-29 | 广东药科大学 | Ginkgo biloba p.e has the application of the drug for the treatment of or health care as synergist in preparation to sleep disturbance disease |
-
2019
- 2019-04-17 CN CN201910306735.XA patent/CN109833381A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101229247A (en) * | 2007-12-28 | 2008-07-30 | 重庆工学院 | Medicine preparation for treating insomnia and preparing method thereof |
| CN106692751A (en) * | 2016-12-29 | 2017-05-24 | 北京康比特体育科技股份有限公司 | Composition for improving exercise-induced insomnia |
| CN109528782A (en) * | 2018-12-30 | 2019-03-29 | 广东药科大学 | Ginkgo biloba p.e has the application of the drug for the treatment of or health care as synergist in preparation to sleep disturbance disease |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464711A (en) * | 2019-09-04 | 2019-11-19 | 西安科力康医药科技有限公司 | A kind of 5 hydroxytryptophan slow-release tablet preparation methods |
| CN111053238A (en) * | 2019-12-30 | 2020-04-24 | 广州市中食科康保健食品有限公司 | Functional food with functions of relieving pressure and helping sleep and preparation method thereof |
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Application publication date: 20190604 |
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