CN107296863A - A kind of medicine for treating senile dementia - Google Patents
A kind of medicine for treating senile dementia Download PDFInfo
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- CN107296863A CN107296863A CN201710452423.0A CN201710452423A CN107296863A CN 107296863 A CN107296863 A CN 107296863A CN 201710452423 A CN201710452423 A CN 201710452423A CN 107296863 A CN107296863 A CN 107296863A
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- senile dementia
- rhodiola root
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- kaempferol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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Abstract
The invention discloses a kind of medicine for treating senile dementia, according to the mass fraction, including 10~14 parts of 120~180 parts of Kaempferol, 250~400 parts of rhodiola root, 160~200 parts of grass-leaved sweetflag, 120~160 parts of climbing seedbox herb, 80~120 parts of rhodiola root, 30~60 parts of earthworm charcoal, 8~20 parts of acetyl-L-carnitine, 800~1200 parts of Radix Caulophylli and motherwort.Present invention applicant obtains the pharmaceutical formulation of scientific and reasonable treatment senile dementia, the invention belongs to treat senile dementia using Kaempferol first by lot of experiments；After the various drug regimens of the present invention, its drug effect cooperates, and can treat senile dementia caused by a variety of causes, effect is good, instant effect.
Description
Technical field
The present invention relates to a kind of medicine for treating senile dementia.
Background technology
Alzheimer disease (Alzheimer's disease, abbreviation AD), is a kind of nervus retrogression disease generally occurred
Disease.It is AD to have up to 50%-60% in dementia patients, and its main clinic symptoms shows as the cognitive decrease of progressive.Greatly
Quantity research confirms that the phenomenon that amyloid-beta (A β) abnormal accumulation is had in the brain of AD patient occurs, wherein A β 25-35 couple
Nerve cell has direct toxic action, is the major toxicity fragment of amyloid-beta, and being with its preparation AD external model can
Capable.
At present, ratify mainly have (1) anticholinesterase for the medicine of senile dementia disease treatment both at home and abroad, commonly use
Medicine has donepezil, galanthamine etc..(2) glutamate receptor antagonists, common drug has memantine.But said medicine
Treat senile dementia and act on single, therapeutic effect is limited, with certain side effect.Therefore, research and development preventing and treating is old
The health food of dull-witted natural safety turns into current important research topic.
Kaempferol (Kaempferol) belong to flavone compound, be a kind of phytoestrogen composition, be widely distributed in shaddock,
In the green plantss such as witch's fibert, tealeaves, the Chinese medicine such as various water fruits and vegetables and the rhizome of davallia.Numerous studies confirm that Kaempferol has
Wider biological activity, it can pre- anti-cancer, antagonism inflammation and microorganism, and cardiovascular and neuron can be produced certain
Protective effect.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of medicine for treating senile dementia.
A kind of medicine for treating senile dementia, its according to the mass fraction, its composition of raw materials is as follows：
120~180 parts of Kaempferol, 250~400 parts of rhodiola root, 160~200 parts of grass-leaved sweetflag, 120~160 parts of climbing seedbox herb,
80~120 parts of rhodiola root, 30~60 parts of earthworm charcoal, 8~20 parts of acetyl-L-carnitine, 800~1200 parts of Radix Caulophylli, motherwort 10
~14 parts；
Wherein, described Radix Caulophylli includes according to the mass fraction：4~6 parts of polyvinyl alcohol, 1~3 part of gelatinized starch, phosphorus stone
2~3 parts of cream, 1~2 part of ammonium sulfate, 1~2 part of sodium chloride, 0.7~0.9 part of prodan, 2~4 parts of potassium chloride, high hydroscopic resin
0.4~0.6 part.
Further, according to the mass fraction, its composition of raw materials is as follows：
140~160 parts of Kaempferol, 300~400 parts of rhodiola root, 160~180 parts of grass-leaved sweetflag, 120~150 parts of climbing seedbox herb,
85~95 parts of rhodiola root, 30~45 parts of earthworm charcoal, 10~20 parts of acetyl-L-carnitine, 850~950 parts of water, motherwort 10~13
Part.
Further, according to the mass fraction, its composition of raw materials is as follows：
150 parts of Kaempferol, 320 parts of rhodiola root, 180 parts of grass-leaved sweetflag, 140 parts of climbing seedbox herb, 90 parts of rhodiola root, earthworm charcoal 40
Part, 14 parts of acetyl-L-carnitine, 900 parts of water, 13 parts of motherwort.
Further, according to the mass fraction, its composition of raw materials is as follows：
120 parts of Kaempferol, 400 parts of rhodiola root, 160 parts of grass-leaved sweetflag, 160 parts of climbing seedbox herb, 80 parts of rhodiola root, earthworm charcoal 60
Part, 8 parts of acetyl-L-carnitine, 1200 parts of Radix Caulophylli, 10 parts of motherwort.
Further, according to the mass fraction, its composition of raw materials is as follows：
180 parts of Kaempferol, 250 parts of rhodiola root, 200 parts of grass-leaved sweetflag, 120 parts of climbing seedbox herb, 120 parts of rhodiola root, earthworm charcoal 30
Part, 20 parts of acetyl-L-carnitine, 800 parts of Radix Caulophylli, 14 parts of motherwort.
The beneficial effect that the present invention is reached：
Present invention applicant obtains the pharmaceutical formulation of scientific and reasonable treatment senile dementia by lot of experiments.This
Invention belongs to treats senile dementia using Kaempferol first, and Kaempferol alternative acts on ER β, promotes p-ERK1/2 table
Reach, active cell ER/MAPK signal transduction pathways, and the expression of Bcl-2 albumen is promoted by the approach, suppress Caspase-3
With the expression of Bax albumen, PC-12 cells are prevented to start apoptosis program, so as to be produced to the PC-12 cells damaged by A β 25-35
Protective effect；After the various drug regimens of the present invention, its drug effect cooperates, and can treat senile dementia caused by a variety of causes
Disease, effect is good, instant effect.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
A kind of medicine for treating senile dementia, according to the mass fraction, its composition of raw materials is as follows：
120 parts of Kaempferol, 400 parts of rhodiola root, 160 parts of grass-leaved sweetflag, 120 parts of climbing seedbox herb, 80 parts of rhodiola root, earthworm charcoal 60
Part, 20 parts of acetyl-L-carnitine, 1200 parts of Radix Caulophylli, 14 parts of motherwort.
Embodiment 2
A kind of medicine for treating senile dementia, according to the mass fraction, its composition of raw materials is as follows：
180 parts of Kaempferol, 250 parts of rhodiola root, 200 parts of grass-leaved sweetflag, 160 parts of climbing seedbox herb, 120 parts of rhodiola root, earthworm charcoal 30
Part, 8 parts of acetyl-L-carnitine, 800 parts of Radix Caulophylli, 10 parts of motherwort.
Embodiment 3
A kind of medicine for treating senile dementia, according to the mass fraction, its composition of raw materials is as follows：
140 parts of Kaempferol, 300 parts of rhodiola root, 160 parts of grass-leaved sweetflag, 120 parts of climbing seedbox herb, 85 parts of rhodiola root, earthworm charcoal 30
Part, 10 parts of acetyl-L-carnitine, 850 parts of Radix Caulophylli, 10 parts of motherwort.
Embodiment 4
A kind of medicine for treating senile dementia, according to the mass fraction, its composition of raw materials is as follows：
160 parts of Kaempferol, 400 parts of rhodiola root, 180 parts of grass-leaved sweetflag, 150 parts of climbing seedbox herb, 95 parts of rhodiola root, earthworm charcoal 45
Part, 20 parts of acetyl-L-carnitine, 950 parts of Radix Caulophylli, 13 parts of motherwort.
Embodiment 5
A kind of medicine for treating senile dementia, according to the mass fraction, its composition of raw materials is as follows：
150 parts of Kaempferol, 320 parts of rhodiola root, 180 parts of grass-leaved sweetflag, 140 parts of climbing seedbox herb, 90 parts of rhodiola root, earthworm charcoal 40
Part, 14 parts of acetyl-L-carnitine, 900 parts of Radix Caulophylli, 13 parts of motherwort.
It is decocted in water for oral dose, every three days one, twice daily.
Model case
Mr. Wang, male, 74 years old, on March 14th, 2013, head was examined, and dizzy palpitaition, insomnia and dreamful sleep, the soreness of waist, mind is blunt, and intelligence is sharp
Subtract, it is forgetful.It is repeatedly lost, the medicine of the present invention is taken, respectively takes 1 time, continuously takes three months sooner or later daily, after three months, patient
Various ill symptomses disappear, intelligence recovers normal, and sleep quality is improved, spirit and QI cleaning.
Lee, female, 77 years old, on June 12nd, 2014, head was examined.Nearest half a year emotional lability, haves the fidgets, and irritability is usually muttered
Mutter and speak to oneself, burnout is thought to crouch, and receives less weak.The medicine of the present invention is taken, respectively takes 1 time, continuously takes 3 months sooner or later daily, patient's
Various ill symptomses disappear, and memory is recovered, and when anything crops up unruffled, it is even-tempered and good-humoured to speak, and appetite recovers normal.
Zheng, female, 82 years old, on March 11st, 2013, head was examined.Usually mumble, burnout is thought sleeping, receives less weak, go out fan
Road.The medicine of the present invention is taken, respectively takes 1 time, continuously takes 2.5 months sooner or later daily, the various ill symptomses of patient disappear, mood
Stable, memory is recovered, and appetite recovers normal.
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., should be included in the present invention's
Within protection domain.
Claims (5)
1. a kind of medicine for treating senile dementia, it is characterised in that according to the mass fraction, its composition of raw materials is as follows：
120~180 parts of Kaempferol, 250~400 parts of rhodiola root, 160~200 parts of grass-leaved sweetflag, 120~160 parts of climbing seedbox herb, red scape
It 80~120 parts, 30~60 parts of earthworm charcoal, 8~20 parts of acetyl-L-carnitine, 800~1200 parts of Radix Caulophylli and motherwort 10~
14 parts.
2. the medicine of senile dementia is treated as claimed in claim 1, it is characterised in that according to the mass fraction, its composition of raw materials
It is as follows：
140~160 parts of Kaempferol, 300~400 parts of rhodiola root, 160~180 parts of grass-leaved sweetflag, 120~150 parts of climbing seedbox herb, red scape
10~13 parts of it 85~95 parts, 30~45 parts of earthworm charcoal, 10~20 parts of acetyl-L-carnitine, 850~950 parts of water and motherwort.
3. the medicine of senile dementia is treated as claimed in claim 2, it is characterised in that according to the mass fraction, its composition of raw materials
It is as follows：
150 parts of Kaempferol, 320 parts of rhodiola root, 180 parts of grass-leaved sweetflag, 140 parts of climbing seedbox herb, 90 parts of rhodiola root, 40 parts of earthworm charcoal, second
13 parts of 14 parts of acyl l-cn, 900 parts of water and motherwort.
4. the medicine of senile dementia is treated as claimed in claim 1, it is characterised in that according to the mass fraction, its composition of raw materials
It is as follows：
120 parts of Kaempferol, 400 parts of rhodiola root, 160 parts of grass-leaved sweetflag, 160 parts of climbing seedbox herb, 80 parts of rhodiola root, 60 parts of earthworm charcoal, second
10 parts of 8 parts of acyl l-cn, 1200 parts of Radix Caulophylli and motherwort.
5. the medicine of senile dementia is treated as claimed in claim 1, it is characterised in that according to the mass fraction, its composition of raw materials
It is as follows：
180 parts of Kaempferol, 250 parts of rhodiola root, 200 parts of grass-leaved sweetflag, 120 parts of climbing seedbox herb, 120 parts of rhodiola root, 30 parts of earthworm charcoal, second
14 parts of 20 parts of acyl l-cn, 800 parts of Radix Caulophylli and motherwort.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710452423.0A CN107296863A (en) | 2017-06-15 | 2017-06-15 | A kind of medicine for treating senile dementia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710452423.0A CN107296863A (en) | 2017-06-15 | 2017-06-15 | A kind of medicine for treating senile dementia |
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| Publication Number | Publication Date |
|---|---|
| CN107296863A true CN107296863A (en) | 2017-10-27 |
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ID=60135706
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| CN201710452423.0A Pending CN107296863A (en) | 2017-06-15 | 2017-06-15 | A kind of medicine for treating senile dementia |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108671019A (en) * | 2018-06-14 | 2018-10-19 | 深圳怡康妇产医院 | Pregnancy promoting soup |
| CN109925463A (en) * | 2017-12-18 | 2019-06-25 | 南宁多灵生物科技有限公司 | A kind of pharmaceutical composition of brain tonic and intelligence development |
| CN109939100A (en) * | 2019-04-22 | 2019-06-28 | 井冈山大学 | Utilize the acetylcholine enzyme inhibitor of close plumage rhizome of cyrtomium preparation, preparation method and application |
| CN112586659A (en) * | 2020-12-11 | 2021-04-02 | 海南黄嘉堡生物科技有限公司 | Formula for treating senile dementia and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940834A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating senile dementia |
-
2017
- 2017-06-15 CN CN201710452423.0A patent/CN107296863A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940834A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating senile dementia |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925463A (en) * | 2017-12-18 | 2019-06-25 | 南宁多灵生物科技有限公司 | A kind of pharmaceutical composition of brain tonic and intelligence development |
| CN108671019A (en) * | 2018-06-14 | 2018-10-19 | 深圳怡康妇产医院 | Pregnancy promoting soup |
| CN109939100A (en) * | 2019-04-22 | 2019-06-28 | 井冈山大学 | Utilize the acetylcholine enzyme inhibitor of close plumage rhizome of cyrtomium preparation, preparation method and application |
| CN109939100B (en) * | 2019-04-22 | 2022-04-19 | 井冈山大学 | Acetylcholine enzyme inhibitor prepared from Cyrtomium fortunei, preparation method and application |
| CN112586659A (en) * | 2020-12-11 | 2021-04-02 | 海南黄嘉堡生物科技有限公司 | Formula for treating senile dementia and preparation method thereof |
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