CN109568240A - A kind of liquid crystal structure essence cream with humectant energy - Google Patents
A kind of liquid crystal structure essence cream with humectant energy Download PDFInfo
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- CN109568240A CN109568240A CN201910017109.9A CN201910017109A CN109568240A CN 109568240 A CN109568240 A CN 109568240A CN 201910017109 A CN201910017109 A CN 201910017109A CN 109568240 A CN109568240 A CN 109568240A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of liquid crystal structure essence creams with humectant energy, mainly contain the component of following mass percentage: Phosphoric acid monohexadecyl ester potassium 1-2%, cetostearyl alcohol 1-3%, -6 distearate 0.5-2% of polyglycereol.The present invention has better moisturizing slow release effect with the liquid crystal structure essence cream of humectant energy, promotes active constituent infiltration, with other compositions compatibility, can effectively moisten nutrition skin, water lock moisturizing.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of liquid crystal structure essence cream with humectant energy.
Background technique
The skin of normal person's health be it is smooth, soft and flexible, under normal circumstances, healthy skin can be produced voluntarily
Raw Protective substances -- natural moisturizing factor (NMF).Natural moisturizing factor results from the outermost cuticula of epidermis, contains hyalomitome
The ingredients such as acid, amino acid, they are skin moisture-keeping, maintain elasticity of skin.High temperature, wind, air-conditioning and other environmental factors can be destroyed
The generation of natural moisturizing factor, therefore skin can become water shortage drying, at this time the skin care compositions of humidity-preserving type just plays a role.
The skin care item of commercial type at present, the instant moisturizing effect of the skin care item of aqua class is preferable, but persistently moisturizing
Effect is slightly worse, loses effect soon in the influence of dry hot environment.The skin care item of emulsifying, normally due to grease adds
Add, can achieve good moisture-keeping function, but due to grease additive amount is more, be easy to cause it is more greasy,
It allows user to feel not pleasant skin sense, and excessive grease, also be easy to cause clogging of pores, cause skin problem.
The present invention is made a kind of with excellent moisture retention, effective drug by forming the emulsification system of liquid crystal structure
Release the control the essence cream composition of function, salubrious skin sense.
Summary of the invention
The purpose of the present invention is to provide a kind of liquid crystal structure essence creams with humectant energy, have excellent moisturizing
The characteristics of property, effective drug release control function, salubrious skin sense.
A kind of liquid crystal structure essence cream with humectant energy, mainly contains the component of following mass percentage:
Phosphoric acid monohexadecyl ester potassium 1-2%,
Cetostearyl alcohol 1-3%,
- 6 distearate 0.5-2% of polyglycereol.
Preferably, the liquid crystal structure essence cream with humectant energy can also contain following mass percentage
Component: phytosterol isostearate 1-2%.
It is further preferred that the liquid crystal structure essence cream with humectant energy mainly contains following quality percentage
The component of content:
Phosphoric acid monohexadecyl ester potassium 2%,
Cetostearyl alcohol 3%,
- 6 distearate 2% of polyglycereol,
Phytosterol isostearate 2%.
In wherein some embodiments, the liquid crystal structure essence cream with humectant energy also contains following quality
The component of percentage composition: sturgeon roe sauce extract 0.1-5%, Chondrus crispus (CHONDRUS CRISPUS) extract 0.1-5%,
Aurelia extract 0.1-5%.
In wherein some embodiments, the liquid crystal structure essence cream with humectant energy also contains following quality
The component of percentage composition: acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, triethanolamine 0.1%,
SEPINOV EMT10 0.8%, trehalose 0.1%, glycerol 8%, hydrolysis Sodium Hyaluronate 0.03%；The wherein SEPINOV
EMT10 is the thickener of plug Bick SEPPIC company, France, component are as follows: hydroxy-ethyl acrylate/acryloyldimethyl taurine
The smooth isostearate of sodium copolymer, sorb, polysorbate -60, water.
In wherein some embodiments, the liquid crystal structure essence cream with humectant energy also contains following quality
The component of percentage composition: ethylhexyl palmitate 3%, Parleam 3%, isooctadecanol isostearate 3%, poly dimethyl
Siloxanes 2%.
Technical solution provided in an embodiment of the present invention has the benefit that
(1) the present invention provides it is a kind of with humectant can liquid crystal structure essence cream, mainly contain Phosphoric acid monohexadecyl ester potassium,
Cetostearyl alcohol, -6 distearate of polyglycereol, phytosterol isostearate, the liquid crystal structure of formation more have moisturizing sustained release
Effect promotes active constituent infiltration, with other compositions compatibility, can effectively moisten nutrition skin, water lock moisturizing.
(2) present invention has compounded sturgeon roe sauce extract, Chondrus crispus (CHONDRUS CRISPUS) extract, Hai Yue
Jellyfish extract can provide sufficient nutriment for skin, and promote osmotic absorption, enhance natural moisturizing factor in skin
The content of NMF improves skin water humidity, enhances skin barrier function, reduces moisture loss.
Figure of description
Fig. 1: structure chart of the 1 gained essence cream sample of embodiment under petrographic microscope；
Fig. 2: structure chart of the 2 gained essence cream sample of embodiment under petrographic microscope；
Fig. 3: structure chart of the 3 gained essence cream sample of embodiment under petrographic microscope；
Fig. 4: structure chart of the 4 gained essence cream sample of embodiment under petrographic microscope；
Fig. 5: structure chart of the 1 gained essence cream sample of comparative example under petrographic microscope.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Sturgeon roe sauce extract of the present invention is process by sturgeon roe (sturgeon ovum).Sturgeon roe is rich in high egg
White, protein content is up to 29%, and microelement rich in and vitamin, belongs to value in skin care circle and diet circle
High luxurious product have the title of " black gold ".Suitable sturgeon roe sauce extract may include CAVIAR EXTACTTMIt (comes from
French En Gerui company).
The essential molecular structure of Chondrus crispus (CHONDRUS CRISPUS) extract of the present invention is linear long
Chain galactose polymer, the coiling of these long-chain galactose derivatives is spiral, constructs the solid space that can lock moisture,
Folding and unfolding can be carried out to hydrone after being applied to skin surface and realize long-acting moisturizing.Suitable Chondrus crispus (CHONDRUS
CRISPUS) extract may include TriDermol Hydrant®(coming from U.S. Biocogent company).
The cosmetics Chinese of aurelia extract of the present invention is jellyfish extract, is from aurelia
Obtained active matter is extracted, there is the function that can improve silk polyprotein synthetic quantity while comprehensively induction epidermal cell differentiation again
Effect.Suitable aurelia extract may include TECHNOLONGTMAurelia (comes from Te Kenuobao Co., Ltd, Japan).
SEPINOV EMT10 of the present invention is the thickener of match Bick SEPPIC company, France, component are as follows: propylene
Sour hydroxyl ethyl ester/sodium acryloyldimethyl taurate copolymers, the smooth isostearate of sorb, polysorbate -60, water.
Embodiment 1
A kind of liquid crystal structure essence cream with humectant energy, the component containing following mass percentage:
Phosphoric acid monohexadecyl ester potassium 1%, cetostearyl alcohol 1%, -6 distearate 0.5% of polyglycereol, phytosterol isostearate
1%, sturgeon roe sauce extract 0.1%, Chondrus crispus (CHONDRUS CRISPUS) extract 5%, aurelia extract
0.1%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, triethanolamine 0.1%, SEPINOV
EMT10 0.8%, trehalose 0.1%, glycerol 8%, hydrolysis Sodium Hyaluronate 0.03%, ethylhexyl palmitate 3%, the poly- isobutyl of hydrogenation
Alkene 3%, isooctadecanol isostearate 3%, dimethyl silicone polymer 2%, water surplus.
Embodiment 2
A kind of liquid crystal structure essence cream with humectant energy, the component containing following mass percentage:
Phosphoric acid monohexadecyl ester potassium 2%, cetostearyl alcohol 3%, -6 distearate 2% of polyglycereol, sturgeon roe sauce extract 5%, ripple
Irish moss (CHONDRUS CRISPUS) extract 0.1%, aurelia extract 5%, acrylic acid (ester) class/C10-30 alkanol
Acrylate crosspolymers 0.1%, triethanolamine 0.1%, SEPINOV EMT10 0.8%, trehalose 0.1%, glycerol 8%, hydrolysis
Sodium Hyaluronate 0.03%, ethylhexyl palmitate 3%, Parleam 3%, isooctadecanol isostearate 3%, poly- diformazan
Radical siloxane 2%, water surplus.
Embodiment 3
A kind of liquid crystal structure essence cream with humectant energy, the component containing following mass percentage:
Phosphoric acid monohexadecyl ester potassium 2%, cetostearyl alcohol 3%, -6 distearate 2% of polyglycereol, phytosterol isostearate 1%,
Sturgeon roe sauce extract 2.5%, Chondrus crispus (CHONDRUS CRISPUS) extract 2.5%, aurelia extract 2.5%,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, triethanolamine 0.1%, SEPINOV EMT10
0.8%, trehalose 0.1%, glycerol 8%, hydrolysis Sodium Hyaluronate 0.03%, ethylhexyl palmitate 3%, Parleam 3%,
Isooctadecanol isostearate 3%, dimethyl silicone polymer 2%, water surplus.
Embodiment 4
A kind of liquid crystal structure essence cream with humectant energy, the component containing following mass percentage:
Phosphoric acid monohexadecyl ester potassium 2%, cetostearyl alcohol 3%, -6 distearate 2% of polyglycereol, phytosterol isostearate 2%,
Sturgeon roe sauce extract 2.5%, Chondrus crispus (CHONDRUS CRISPUS) extract 2.5%, aurelia extract 2.5%,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, triethanolamine 0.1%, SEPINOV EMT10
0.8%, trehalose 0.1%, glycerol 8%, hydrolysis Sodium Hyaluronate 0.03%, ethylhexyl palmitate 3%, Parleam 3%,
Isooctadecanol isostearate 3%, dimethyl silicone polymer 2%, water surplus.
Comparative example 1
A kind of liquid crystal structure essence cream with humectant energy, the component containing following mass percentage:
Phosphoric acid monohexadecyl ester potassium 2%, cetostearyl alcohol 3%, -6 distearate 2% of polyglycereol, phytosterol isostearate 3%,
Sturgeon roe sauce extract 2.5%, Chondrus crispus (CHONDRUS CRISPUS) extract 2.5%, aurelia extract 2.5%,
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, triethanolamine 0.1%, SEPINOV EMT10
0.8%, trehalose 0.1%, glycerol 8%, hydrolysis Sodium Hyaluronate 0.03%, ethylhexyl palmitate 3%, Parleam 3%,
Isooctadecanol isostearate 3%, dimethyl silicone polymer 2%, water surplus.
Test the test of 1 physical and chemical index
Sensory testing: the character of product is visually observed, exception is seen if there is；
Resistance to Thermal test: sample is put into the electro-heating standing-temperature cultivator of (40 ± 1) C for 24 hours, has seen whether change after restoring room temperature
Phenomena such as dilute, discoloration, layering and firmness change, with the heat resistance of judgement sample；
Cold-resistant test: sample is put into the refrigerator of ± 1 C of (- 5 ~ -10) C for 24 hours, restore to have seen whether after room temperature it is thinning,
Phenomena such as discoloration, layering and firmness change, with the cold tolerance of judgement sample；
It the results are shown in Table 1.
1 physical and chemical index test result of 1. embodiment 1-4 of table and comparative example
The result shows that the essence cream system stability of inventive formulation composition is good.
Test the test of 2 liquid crystal structures
Liquid crystal image (10 times of the eyepiece, object lens of observation embodiment 1-4 and the essence cream sample of comparative example 1 under petrographic microscope
10 times).As a result as shown in attached drawing 1-5.
It compares from liquid crystal image as it can be seen that the addition of phytosterol isostearate can play promotion liquid in the emulsification system
The effect of brilliant effect；But phytosterol isostearate additive amount reaches 3% comparative example 1, liquid crystal phenomenon disappears.Thus may be used
See, in the system, the addition of phytosterol isostearate can promote the formation of liquid crystal, but additive amount when being more than 3% then
It can occur to inhibit liquid crystal, the negative effect of formation.
By multiple comparison test, the present invention compounds to obtain the optimal proportion of the emulsification system of stable liquid crystal structure are as follows:
Phosphoric acid monohexadecyl ester potassium 2%, cetostearyl alcohol 3%, -6 distearate 2% of polyglycereol, phytosterol isostearate 2%.
Test 3 human skin patch
30 trial volunteers are selected, the age 25-50 years old, masculinity femininity was fifty-fifty, subjects skin's health, no skin disease allergy
History meets subject and volunteers inclusion criteria, carries out patch test.Qualified patch device is selected, with enclosed patch test method,
By 1 gained essence cream sample of tested material embodiment 1-4 and comparative example, respectively about 0.05g is uniformly applied in patch device, and external application is dedicated
Adhesive tape is covered on subject's forearm, and tested material is removed after 24 hours, 0.5,6,12,24,48 hour observation skin after removing respectively
Reaction, records its result according to dermoreaction grade scale in " cosmetics health specification ".
Human skin patch test result is shown: 30 subjects through the invention it is described with humectant can liquid
Crystal structure essence cream (embodiment 1-4 and comparative example 1) patch test, in observation dermoreaction in 0.5,6,12,24,48 hour,
In 0 there is skin adverse reaction, illustrate it is of the present invention with humectant can liquid crystal structure essence cream using safe.
Test 4 crowds test on probation
The sample of the liquid crystal structure essence cream with humectant energy and comparative example 1 that this experimental selection case study on implementation 1-3 is provided
It is tested.
According to light industry standard QB/T 4256-2011 cosmetics moisture-keeping efficacy evaluation guide, comparing embodiment 1-4 and
The moistening effect of 1 gained sample of comparative example.
Experimental principle: the moisture content using capacitance method measurement human skin keratinocyte's layer is based on water and other substances
Difference in dielectric constant is significant, and according to the difference of keratoderma moisture content, the capacitance of the skin measured is different, and parameter can
Skin moisture content is represented, moisture content of skin is carried out by the Corneometer CM825 probe of Multi-functional skin tester
Test, the probe are the variations for reflecting moisture of skin by measuring the capacitance of skin, and CM value is higher to represent water content of stratum corneum
It is higher.
Laboratory apparatus: Corneometer CM825
Experimental program: experiment each group is taken one's test with 20 volunteers, and 10 males, 10 women, the age was at 24~50 years old.Before
Arm test zone basic value is in 15~30(Corneomter Unit, C.U) between, before tested, it is double that subject unifies clear water cleaning
Hand inner forearm, is dried with paper handkerchief, and in test environment temperature: 20 DEG C~22 DEG C, humidity: sit quietly 20min under 40%~60% environment,
Sample and blank district are distributed in volunteer's inner forearm region by test zone random distribution table, and the size in each region is
4.0cm × 5.0cm, amount of samples are (2.0 ± 0.1) mg/cm2.Using before product, using product after 20min, 40min,
1h, 2h, 4h carry out the test of keratoderma moisture content.With pure water, it is not coated with sample (blank), does control group.
Comparative example 1: the difference with embodiment 1-4 is that 1 gained sample of comparative example is not liquid crystal structure essence cream.
Experimental data: the data of keratoderma moisture content and keratoderma moisture content change rate remove maximum
Value and minimum value, are averaged.Its result is as shown in table 2 and table 3.
2 keratoderma water content test result record sheet of table
3 keratoderma change of moisture content rate test result record sheet of table
From upper table 2, table 3 as it can be seen that after liquid crystal structure essence cream using 1-4 of the embodiment of the present invention, water content i.e. CM value is measured
Decline is slower, and the subject used indicates that the replenishing water and preserving moisture effect of liquid crystal structure essence cream is good, and skin water profit is felt after use,
Illustrate that liquid crystal structure essence cream of the present invention has good water lock moistening effect.
Embodiment 1-4 and comparative example 1 compare the liquid crystal structure essence cream it is found that 1-4 of the embodiment of the present invention, have better
Moisturizing slow release effect promotes active constituent infiltration, with other compositions compatibility, can effectively moisten nutrition skin, water lock moisturizing;Comparison
Example 1 is resulting not to have liquid crystal structure essence cream, and water lock moistening effect is relatively poor.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (6)
1. a kind of liquid crystal structure essence cream with humectant energy, which is characterized in that mainly contain following mass percentage
Component:
Phosphoric acid monohexadecyl ester potassium 1-2%,
Cetostearyl alcohol 1-3%,
- 6 distearate 0.5-2% of polyglycereol.
2. the liquid crystal structure essence cream according to claim 1 with humectant energy, which is characterized in that described has
The liquid crystal structure essence cream of humectant energy also contains the component of following mass percentage: phytosterol isostearate 1-
2%。
3. the liquid crystal structure essence cream according to claim 1 with humectant energy, which is characterized in that described has
The liquid crystal structure essence cream of humectant energy mainly contains the component of following mass percentage:
Phosphoric acid monohexadecyl ester potassium 2%,
Cetostearyl alcohol 3%,
- 6 distearate 2% of polyglycereol,
Phytosterol isostearate 2%.
4. the liquid crystal structure essence cream according to claim 1 with humectant energy, which is characterized in that described has
Humectant can liquid crystal structure essence cream also contain the component of following mass percentage: sturgeon roe sauce extract 0.1-5%,
Chondrus crispus (CHONDRUS CRISPUS) extract 0.1-5%, aurelia extract 0.1-5%.
5. the liquid crystal structure essence cream according to claim 1 with humectant energy, which is characterized in that described has
The liquid crystal structure essence cream of humectant energy also contains the component of following mass percentage: acrylic acid (ester) class/C10-30 alkane
Alcohol acrylate crosspolymers 0.1%, triethanolamine 0.1%, SEPINOV EMT10 0.8%, trehalose 0.1%, glycerol 8%, water
Solve Sodium Hyaluronate 0.03%；Wherein the SEPINOV EMT10 is the thickener of plug Bick SEPPIC company, France, group
Be divided into: the smooth isostearate of hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, sorb, polysorbate -60,
Water.
6. the liquid crystal structure essence cream according to claim 1 with humectant energy, which is characterized in that described has
The liquid crystal structure essence cream of humectant energy also contains the component of following mass percentage: ethylhexyl palmitate 3%, hydrogenation
Polyisobutene 3%, isooctadecanol isostearate 3%, dimethyl silicone polymer 2%.
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| CN111529464A (en) * | 2020-05-20 | 2020-08-14 | 广东创美抗衰老研究有限公司 | Moisturizing cream suitable for diabetic patients |
| CN111588648A (en) * | 2020-05-22 | 2020-08-28 | 广东创美抗衰老研究有限公司 | Autophagy rejuvenation anti-aging cream |
| CN111789783A (en) * | 2020-07-22 | 2020-10-20 | 珠海姗拉娜化妆品有限公司 | Skin protection film composition and preparation method thereof |
| CN113559049A (en) * | 2021-08-26 | 2021-10-29 | 杭州舒彩网络科技有限公司 | Sustained-release moisturizing cream and preparation method thereof |
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Effective date of registration: 20200228 Address after: 510000 3a, building C6, NO.213, South huangbian Road, Baiyun District, Guangzhou City, Guangdong Province Applicant after: GUANGZHOU YUEHUI COSMETICS Co.,Ltd. Address before: 200120, B, building 858, building 977, 1 Feng Feng Road, Shanghai, Pudong New Area Applicant before: SHANGHAI YUEMU COSMETIC CO.,LTD. |
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