CN111588648A - Autophagy rejuvenation anti-aging cream - Google Patents

Autophagy rejuvenation anti-aging cream Download PDF

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Publication number
CN111588648A
CN111588648A CN202010438855.8A CN202010438855A CN111588648A CN 111588648 A CN111588648 A CN 111588648A CN 202010438855 A CN202010438855 A CN 202010438855A CN 111588648 A CN111588648 A CN 111588648A
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phase
parts
autophagy
stirring
extract
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尹卫群
蔡光欣
黄丽翠
吴嫦颜
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Guangdong Chuangmei Anti Aging Research Co ltd
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Guangdong Chuangmei Anti Aging Research Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0295—Liquid crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an autophagy rejuvenation anti-aging cream which is characterized by comprising a phase A, a phase B, a phase C, a phase D, a phase E and a phase F, wherein the phase A comprises 1 part of sucrose polystearate and cetyl palmitate, 2.5 parts of cetearyl glucoside and cetearyl alcohol, 3 parts of propylene glycol and 2 parts of cetearyl alcohol, and the phase B comprises 6 parts of triglyceride, 3 parts of coco-caprylate/caprate, 2 parts of hydrogenated polyisobutene, 1 part of polydimethylsiloxane, 3 parts of shea butter, 1 part of myristyl myristate and 0.5 part of tocopherol; according to the invention, the trehalose is wrapped by adding the autophagy initiator to wrap nutritional ingredients such as trehalose through a liquid crystal type emulsification system, and the autophagy rejuvenation anti-aging cream of the anti-aging skin care product of the autophagy initiator is prepared through a liquid crystal type emulsification step.

Description

Autophagy rejuvenation anti-aging cream
Technical Field
The invention relates to the technical field, in particular to an autophagy rejuvenation anti-aging cream.
Background
With the increase of the pace of life, the aging speed of human skin is greatly increased, resulting in dry skin and uneven complexion. However, in the prior art, the formula is rarely directed to skin care products which activate the autophagy mechanism of the human body, and the autophagy of the skin is a natural process, and the detoxification process of continuously degrading and continuously updating damaged cell components is adopted, so that the autophagy rejuvenation anti-aging cream is urgently needed to be designed to solve the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides an autophagy skin-refreshing anti-aging cream.
In order to achieve the purpose, the invention adopts the following technical scheme:
an autophagy whitening anti-aging cream is characterized by comprising a phase A, a phase B, a phase C, a phase D, a phase E and a phase F, wherein the phase A comprises 1 part of sucrose polystearate and cetyl palmitate, 2.5 parts of cetearyl glucoside and cetearyl alcohol, 3 parts of propylene glycol and 2 parts of cetearyl alcohol, the phase B comprises 6 parts of triglyceride, 3 parts of coco-caprylate/caprate, 2 parts of hydrogenated polyisobutene, 1 part of polydimethylsiloxane, 3 parts of shea butter, 1 part of myristyl myristate and 0.5 part of tocopherol, the phase C comprises 0.2 part of sodium polyacrylate, 4 parts of glycerol, 2 parts of butanediol and 5 parts of 1, 2-pentanediol, the phase D comprises 52.8 parts of deionized water and 5 parts of a moisturizing extract, the phase E comprises 0.2 part of carboxymethyl chitosan and 3 parts of deionized water, and the phase F comprises 5 parts of a conditioning extract and 3 parts of deionized water, the conditioning extract comprises water, butylene glycol, trehalose, hydrogenated lecithin, carbomer, and Chondrus crispus extract.
Further, the moisturizing extract comprises water, glycerin, stem extract of dendrobium stem, leaf extract of aloe vera, root extract of sophora flavescens ait, fruit extract of lycium barbarum and echinacea extract.
Further, sucrose polystearate and cetyl palmitate, cetearyl glucoside and cetearyl alcohol of the phase a are used as emulsifiers.
Further, the tocopherol of phase B is primarily vitamin E acting as a skin conditioner, with the remainder being emollients.
Further, the deionized water of the phase D is used as a solvent to mix the moisturizing extracts into the moisturizing agent.
The manufacturing process comprises the following steps:
respectively heating the S1 phase and the C A, B phase to mix, heating the C phase, adding the C phase into the A, B phase mixed solution, and fully stirring until the components are uniformly dispersed;
s2, adding the phase B into the phase A in a water bath kettle, and uniformly stirring; cooling to 55 ℃;
s3, adding the phase C into the phase A + phase B in a water bath kettle under the condition of continuously stirring, stirring and mixing uniformly, stirring and dispersing uniformly, homogenizing, and then cooling and stirring;
and S4, cooling to 40 ℃, adding the phase D, the phase E and the phase F, stirring and dispersing uniformly until the temperature is room temperature, and filling.
Further, the A, B phases were mixed and heated to 80 ℃ and the C phase was heated to 55 ℃.
Further, the homogenization speed of stirring in S3 is 8000, and stirring is performed for 20 min.
The invention has the beneficial effects that:
1. the autophagy rejuvenation anti-aging cream is prepared by wrapping trehalose and other nutritional ingredients by adding an autophagy initiator through a liquid crystal type emulsification system and performing a liquid crystal type emulsification step to prepare the autophagy rejuvenation anti-aging cream which wraps the trehalose and plays a role in anti-aging skin care products of the autophagy initiator.
2. The invention can eliminate the amyloid protein expression (a skin aging index) on human skin, so as to improve the skin color uniformity, moisten the cuticle, and improve the size and the visible degree of the fishtail line.
Drawings
Fig. 1 is a schematic structural view of an autophagy rejuvenation anti-aging cream provided by the present invention;
fig. 2 is a schematic diagram of CPD damage of the autophagy rejuvenation anti-aging cream provided by the present invention;
fig. 3 is a schematic diagram of 8OHdG lesions of the autophagy rejuvenation anti-aging cream provided by the present invention;
fig. 4 is a schematic diagram of CP damage of an autophagy rejuvenation anti-aging cream according to the present invention;
FIG. 5 is a graph of the reduction of pigmentation following UVB irradiation of algal glycolipid plastids according to the invention;
FIG. 6 is a diagram showing the reduction of existing color spots in the algal glycolipid plastid proposed by the present invention;
FIG. 7 is a graph of the reduction of skin aging by algal glycolipid plasmids proposed by the present invention;
FIG. 8 is a graph of the improvement of skin tone uniformity and moisturization of the algal glycolipid plastids proposed by the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1
Referring to fig. 1 to 8, the self-service skin rejuvenating and anti-aging cream is characterized by comprising a phase a, a phase B, a phase C, a phase D, a phase E and a phase F, wherein the phase a comprises 1 part of sucrose polystearate and cetyl palmitate, 2.5 parts of cetearyl glucoside and cetearyl alcohol, 3 parts of propylene glycol and 2 parts of cetearyl alcohol, the phase B comprises 6 parts of triglyceride, 3 parts of coco-caprylate, 2 parts of hydrogenated polyisobutene, 1 part of polydimethylsiloxane, 3 parts of shea butter, 1 part of myristyl myristate and 0.5 part of tocopherol, the phase C comprises 0.2 part of sodium polyacrylate, 4 parts of glycerol, 2 parts of butylene glycol and 5 parts of 1, 2-pentanediol, the phase D comprises 52.8 parts of deionized water and 5 parts of a moisturizing extract, the phase E comprises 0.2 part of carboxymethyl chitosan and 3 parts of deionized water, the phase F comprises 5 parts of a conditioning extract and 3 parts of deionized water, the conditioning extract comprises water, butylene glycol, trehalose, hydrogenated lecithin, carbomer, and Chondrus crispus extract.
Further, the moisturizing extract includes water, glycerin, stem extract of dendrobium stem, leaf extract of aloe vera, root extract of sophora flavescens ait, fruit extract of lycium barbarum and echinacea extract.
Further, sucrose polystearate and cetyl palmitate, cetearyl glucoside and cetearyl alcohol were used as emulsifiers in phase A.
Furthermore, the tocopherol in phase B is primarily vitamin E acting as a skin conditioner, with the remainder being emollients.
Further, deionized water in the phase D serves as a solvent to mix the moisturizing extract into the moisturizing agent.
The manufacturing process comprises the following steps:
respectively heating the S1 phase and the C A, B phase to mix, heating the C phase, adding the C phase into the A, B phase mixed solution, and fully stirring until the components are uniformly dispersed;
s2, adding the phase B into the phase A in a water bath kettle, and uniformly stirring; cooling to 55 ℃;
s3, adding the phase C into the phase A + phase B in a water bath kettle under the condition of continuously stirring, stirring and mixing uniformly, stirring and dispersing uniformly, homogenizing, and then cooling and stirring;
and S4, cooling to 40 ℃, adding the phase D, the phase E and the phase F, stirring and dispersing uniformly until the temperature is room temperature, and filling.
Further, A, B phases were mixed and heated to 80 ℃ and C phase was heated to 55 ℃.
Further, the homogenization speed of stirring in S3 was 8000, and stirring was performed for 20 min.
Example 2
Referring to fig. 1 to 8, the self-service whitening anti-aging cream is characterized by comprising a phase A, a phase B, a phase C, a phase D, a phase E and a phase F, wherein the phase A comprises 1 part of sucrose polystearate and cetyl palmitate, 2.5 parts of cetearyl glucoside and cetearyl alcohol, 3 parts of propylene glycol and 2 parts of cetearyl alcohol, the phase B comprises 6 parts of triglyceride, 3 parts of decanoate, 2 parts of hydrogenated polyisobutene, 1 part of polydimethylsiloxane, 3 parts of shea butter, 1 part of myristyl myristate and 0.5 part of tocopherol, the phase C comprises 0.2 part of sodium polyacrylate, 4 parts of glycerol, 2 parts of butanediol and 5 parts of 1, 2-pentanediol, the phase D comprises 52.8 parts of deionized water and 5 parts of a moisturizing extract, the phase E comprises 0.2 part of carboxymethyl chitosan and 3 parts of deionized water, the phase F comprises 5 parts of a conditioning extract and 3 parts of deionized water, the conditioning extract comprises water, butylene glycol, trehalose, hydrogenated lecithin, carbomer, and Chondrus crispus extract.
Further, the moisturizing extract includes water, glycerin, stem extract of dendrobium stem, leaf extract of aloe vera, root extract of sophora flavescens ait, fruit extract of lycium barbarum and echinacea extract.
Further, sucrose polystearate and cetyl palmitate, cetearyl glucoside and cetearyl alcohol were used as emulsifiers in phase A.
Furthermore, the tocopherol in phase B is primarily vitamin E acting as a skin conditioner, with the remainder being emollients.
Further, deionized water in the phase D serves as a solvent to mix the moisturizing extract into the moisturizing agent.
The manufacturing process comprises the following steps:
respectively heating the S1 phase and the C A, B phase to mix, heating the C phase, adding the C phase into the A, B phase mixed solution, and fully stirring until the components are uniformly dispersed;
s2, adding the phase B into the phase A in a water bath kettle, and uniformly stirring; cooling to 55 ℃;
s3, adding the phase C into the phase A + phase B in a water bath kettle under the condition of continuously stirring, stirring and mixing uniformly, stirring and dispersing uniformly, homogenizing, and then cooling and stirring;
and S4, cooling to 40 ℃, adding the phase D, the phase E and the phase F, stirring and dispersing uniformly until the temperature is room temperature, and filling.
Further, A, B phases were mixed and heated to 80 ℃ and C phase was heated to 55 ℃.
Further, the homogenization speed of stirring in S3 was 8000, and stirring was performed for 20 min.
As shown in fig. 2-4: comparative data for trehalose loaded liposomes vs trehalose not added liposomes
Figure BDA0002503308000000071
Whitening effect of seaweed glycolipid.
The seaweed glycolipid plastid has the effect of preventing skin color spots, namely reducing color spots after UV irradiation; the healing efficacy is that the existing color spots are reduced.
The clinical effect is as follows: 10 caucasian volunteers (8 females and males, average age: 44 years), applied externally applied cream containing 5% of exemriosis to the face and neck twice a day (once in the morning and evening) for 45 days, and the degree of wetting of the horny layer of the epidermis was evaluated by a skin moisturizing tester and the degree of skin color uniformity and the degree of crow's feet by a skin surface analyzer.
As shown in fig. 7 and 8, the present invention has a superior effect of removing the expression of amyloidogenic proteins on human skin, improving skin color uniformity, cuticle moisturization, fishtail size and visibility, and reducing wrinkles.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (8)

1. An autophagy whitening anti-aging cream is characterized by comprising a phase A, a phase B, a phase C, a phase D, a phase E and a phase F, wherein the phase A comprises 1 part of sucrose polystearate and cetyl palmitate, 2.5 parts of cetearyl glucoside and cetearyl alcohol, 3 parts of propylene glycol and 2 parts of cetearyl alcohol, the phase B comprises 6 parts of triglyceride, 3 parts of coco-caprylate/caprate, 2 parts of hydrogenated polyisobutene, 1 part of polydimethylsiloxane, 3 parts of shea butter, 1 part of myristyl myristate and 0.5 part of tocopherol, the phase C comprises 0.2 part of sodium polyacrylate, 4 parts of glycerol, 2 parts of butanediol and 5 parts of 1, 2-pentanediol, the phase D comprises 52.8 parts of deionized water and 5 parts of a moisturizing extract, the phase E comprises 0.2 part of carboxymethyl chitosan and 3 parts of deionized water, and the phase F comprises 5 parts of a conditioning extract and 3 parts of deionized water, the conditioning extract comprises water, butylene glycol, trehalose, hydrogenated lecithin, carbomer, and Chondrus crispus extract.
2. The autophagy rejuvenating anti-aging cream according to claim 1, wherein the moisturizing extract comprises water, glycerin, stem extract of dendrobium nobile, leaf extract of aloe barbadensis, root extract of sophora flavescens ait, fruit extract of lycium barbarum and echinacea purpurea.
3. The autophagy peel cream according to claim 1, characterized in that sucrose polystearate and cetyl palmitate, cetearyl glucoside and cetearyl alcohol of phase a are used as emulsifiers.
4. The autophagy peel anti-aging cream according to claim 1, characterized in that the tocopherol of phase B is mainly vitamin E acting as a skin conditioner, and the balance is an emollient.
5. The autophagy peel anti-aging cream according to claim 1, wherein the deionized water of phase D acts as a solvent to mix moisturizing extracts into a moisturizer.
6. The process for making an autophagy peel anti-aging cream according to any one of claims 1 to 5, comprising the steps of:
respectively heating the S1 phase and the C A, B phase to mix, heating the C phase, adding the C phase into the A, B phase mixed solution, and fully stirring until the components are uniformly dispersed;
s2, adding the phase B into the phase A in a water bath kettle, and uniformly stirring; cooling to 55 ℃;
s3, adding the phase C into the phase A + phase B in a water bath kettle under the condition of continuously stirring, stirring and mixing uniformly, stirring and dispersing uniformly, homogenizing, and then cooling and stirring;
and S4, cooling to 40 ℃, adding the phase D, the phase E and the phase F, stirring and dispersing uniformly until the temperature is room temperature, and filling.
7. The process of claim 6, wherein A, B is heated by mixing at 80 ℃ and C is heated at 55 ℃.
8. The process of claim 6, wherein the homogenization speed of the stirring in S3 is 8000, and the stirring is performed for 20 min.
CN202010438855.8A 2020-05-22 2020-05-22 Autophagy rejuvenation anti-aging cream Pending CN111588648A (en)

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CN112516054A (en) * 2020-12-30 2021-03-19 福建臻昕美生物科技有限公司 Tea polyphenol protein cream for repairing, moisturizing and strengthening skin and production process thereof

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Publication number Priority date Publication date Assignee Title
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CN112516054A (en) * 2020-12-30 2021-03-19 福建臻昕美生物科技有限公司 Tea polyphenol protein cream for repairing, moisturizing and strengthening skin and production process thereof

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