CN108403610A - A kind of lip repair and preparation method thereof with cracking resistance - Google Patents

A kind of lip repair and preparation method thereof with cracking resistance Download PDF

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Publication number
CN108403610A
CN108403610A CN201810561195.5A CN201810561195A CN108403610A CN 108403610 A CN108403610 A CN 108403610A CN 201810561195 A CN201810561195 A CN 201810561195A CN 108403610 A CN108403610 A CN 108403610A
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China
Prior art keywords
weight
parts
lip
lip repair
present
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CN201810561195.5A
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Inventor
吉日木图
高杰
何静
明亮
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Camel Research Institute in Inner Mongolia
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Inner Mongolia Agricultural University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/001Preparations for care of the lips

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Insects & Arthropods (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a kind of lip repair and preparation method thereof.The lip repair contains the components such as hunchbacked fat, oil, wax, moisturizer, emollients, antioxidant, essence;Lip repair white color of the present invention and it is bright, quality is fine and smooth, non-stimulated to skin, can not only prevent dry skin crack, moreover it is possible to further restore and keep the natural elasticity of skin, have good deep layer moisten moisture-keeping efficacy.

Description

A kind of lip repair and preparation method thereof with cracking resistance
【Technical field】
The present invention relates to cosmetic technical fields.More particularly it relates to a kind of maintenance profit with cracking resistance Lipstick further relates to described have effects that the preparation method of the lip repair of cracking resistance.
【Background technology】
Cosmetic product may be directly applied to human skin outer surface.The certain ingredients of cosmetics may permeate into the human body. Lip balm product is directed to lip special physiological structure and designs, and lip cosmetic can be divided into rodlike lip according to its form Cream, lip liner, lip gloss and lip oil etc..Lipstick can assign gloss to lip, prevent dry and cracked, increase glamour.Since lip is made up Product are directly applied to lip and easily enter the mouth, therefore lip balm product should not have specific peculiar smell, and security requirement is high, nontoxic to human body Property, it is nonirritant etc. to mucous membrane.Lip cuticula is thin, fast without sebaceous glands, moisture evaporation rate, and natural moisturizing factor is also few, because This lip is more sensitive, it is easier to occur dry and cracked.So a kind of natural cracking resistance lipstick of exploitation can win the favor of consumer.
Northern area air humidity is low, and dust storm is big, and many frequent lips of people are dry and cracked, the bleeding of corners of the mouth breach, pain, in doctor trained in Western medicine Referred to as angular stomatitis, angular stomatitis belong to a kind of chronic dermatitis.Dry and cracked lip is since lip lacks moisture and grease, dimension life in vivo Caused by plain B2, vitamin A intake deficiency.Treat the lip dry and cracked vitamin B2 and vitamin A sufficient in addition to intake it Outside, most effective and simple method is exactly to use lip gloss.
Camel is the main poultry kind survived in desert arid area, can resist scorching summer and freezing winter, dust storm is exposed to the sun, hungry water shortage Etc. adverse circumstances, research shows that this has inseparable relationship with the fat laid in its hump.Therefore its camel extracted Peak oil certainly will also have the effect of nourishing moisturizing.Hump fat is the subcutaneous fat under the latissimus dorsi tissue of camel back protrusion Fat is two-humped camel body fat main source.Hump fat contains a large amount of triglycerides, unsaturated fatty acid and a variety of nutrition Ingredient.Hunchbacked fat room temperature is white, solidifies shape, and hunchbacked fat is in yellowish, free from extraneous odour after fusing.Fatty acid species in hunchbacked fat are more, and Unsaturated fatty acid content is higher, can repair the damage in cells of superficial layer membrane structure, improves cell activity.
Therefore, the present inventor is summarizing on prior art basis, by many experiments and analysis and research, completes finally The present invention.
【Invention content】
[technical problems to be solved]
Having effects that the lip repair of cracking resistance the purpose of the present invention is to provide a kind of.
It is a further object to provide the preparation methods with the lip repair of cracking resistance.
[technical solution]
The present invention is achieved through the following technical solutions.
Having effects that the lip repair of cracking resistance the present invention relates to a kind of.
Lip repair composition is as follows:In parts by weight
A preferred embodiment of the invention, the vegetable oil are one or more selected from castor oil, olive The vegetable oil of oil, Queensland nut seed oil, shea butter, jojoba oil or white pond flower seed oil.
According to another preferred method of implementation of the present invention, the wax is one or more selected from cera alba, small candle tree The wax of wax, palm vegetable wax or ceresine.
According to another preferred method of implementation of the present invention, the emollients are one or more selected from octyl 12 The emollients of alcohol, sad certain herbaceous plants with big flowers acid glycerol three ester or dimethyl silicone polymer.
According to another preferred method of implementation of the present invention, the moisturizer is one or more selected from vaseline, angle The moisturizer of shark alkane or hyaluronic acid.
According to another preferred method of implementation of the present invention, the antioxidant is one or more selected from tocopherol second The antioxidant of acetoacetic ester, grape seed oil or vitamin E.
According to another preferred method of implementation of the present invention, the film forming agent is one or more selected from the poly- isobutyl of hydrogenation The film forming agent of alkene, glycerin monostearate or polybutene.
According to another preferred method of implementation of the present invention, the preservative is one or more selected from fourth hydroxyl first The preservative of benzene, Phenoxyethanol or Nipasol.
According to another preferred method of implementation of the present invention, the essence is flavoring apple essence or peach flavor.
The invention further relates to the preparation methods of the lip repair.
The step of preparation method, is as follows:
A, 30~50 parts by weight vegetable oil and 10~20 parts by weight hump fat heat in water-bath at 50-60 DEG C of temperature Dissolving, is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, 10~30 parts by weight waxes, 1~10 weight is added into the transparency liquid Part film forming agent, 5~10 parts by weight moisturizer and 1~15 parts by weight emollients, stir evenly;
C, the homogeneous mixture that step B is obtained vacuum outgas 1 under conditions of 85 DEG C of temperature and 0.02~0.08MPa of pressure Then it is anti-oxidant that 0.1~0.3 parts by weight essence, 0.05~0.1 parts by weight preservative and 0.1~0.5 parts by weight are added in~3min Agent is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the temperature that step C is obtained is 70~90 DEG C Mixture injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The present invention is described in more detail below.
The characteristics of the present inventor is according to hunchbacked fat, with the fatty acid species rich content of hunchbacked fat, wherein main contain palm Acid, stearic acid, oleic acid, palmitoleic acid and myristic acid, and its contained content of fatty acid and ratio and people's epidermis lipid content are close For Research foundation, a kind of lip repair with moisturizing, cracking resistance effect containing natural hunchbacked fat ingredient is developed.Research hair Existing, hunchbacked fat can promote skin preferably to absorb, moreover it is possible to protect moisture is too fast to scatter and disappear.Therefore, lip is moistened in cracking resistance maintenance of the invention Cream is a kind of lipstick containing hunchbacked fat active ingredient.
Having effects that the lip repair of cracking resistance the present invention relates to a kind of.
The composition of the lip repair is as follows:In parts by weight
Hump fat contains abundant collagen, highly unsaturated fatty acid and vitamin E, hunchbacked fat fat globule particle diameter pole Small, permeability is strong, is easily absorbed by the skin, wherein human body vis medicatrix naturae and metabolism can be promoted to accelerate rich in immunologic active material, Promote neoblast regeneration.Therefore, select hump fat as the primary raw material of lip repair of the present invention in the present invention.
The specific extracting method of hump fat that the present invention uses is as follows:
Camel is after butchering, fresh, the clean and intact hump subcutaneous fat of acquisition, these adipose tissues do not have bone, broken Skin, internal organs, thyroid gland, adrenal gland, lymph node, tracheae, thick blood vessel, heavy clear, squeezing material and other analogs, and should be as far as possible Without musculature and blood vessel.These adipose tissues are placed in rubbing in pot, and hunchbacked fat is completely melt by heating, then make liquid hunchbacked Fat is sieved, and obtains refined hump fat, its color is bordering on faint yellow, transparent oil body, no specific peculiar smell.
In the present invention, when other components are in the content range, if hump fat content is less than 10 parts by weight, Lip repair effect obtained is bad;If hump fat content is higher than 20 parts by weight, lip repair obtained can be too It is greasy;Therefore, hump fat content is that 10~20 parts by weight are reasonable, preferably 12~18 parts by weight, more preferably 14 ~16 parts by weight.
Main function of the vegetable oil in lip repair of the present invention be moisturizing, it is soft and moist, avoid moisture loss.
In the present invention, when other components are in the content range, if content of vegetable oil is less than 30 parts by weight, Lip repair moistness obtained is poor;If content of vegetable oil is higher than 50 parts by weight, lipstick can be made too greasy or sweating;Cause This, content of vegetable oil is that 30~50 parts by weight are appropriate, preferably 35~45 parts by weight, more preferably 38~42 weight Part.
The vegetable oil that the present invention uses is one or more selected from castor oil, olive oil, Queensland nut seed oil, the wooden fruit of breast The vegetable oil of oil, jojoba oil or white pond flower seed oil.
The vegetable oil that the present invention uses all is current market sales of product, such as by the Guangzhou Chinese mugwort limited public affairs of bit trade Department is oily, wooden with trade name breast by Shandong You Suo Chemical Industry Science Co., Ltd with the Queensland nut seed that trade name macadimia nut oil is sold Fruit oil sale shea butter, by Guangzhou Chinese mugwort bit trade Co., Ltd sold with trade name jojoba oil jojoba oil, by Shenzhen Ying Bote foreign trades Co., Ltd is with the white pond flower seed oil of the white pond flower seed oil sale of trade name.
Main function of the wax in lip repair of the present invention is to improve lipstick stability, increase lipstick hardness, Lipstick is set to keep due shape at normal temperatures.
In the present invention, when other components are in the content range, if wax content is less than 10 parts by weight, can make Lip repair is easily broken off, if wax content is higher than 30 parts by weight, lip repair can be made too hard, to influence lipstick paving Malleability;Therefore, it is suitable, preferably 15~25 parts by weight that wax content, which is 10~30 parts by weight, more preferably 18~22 Parts by weight.
The wax that the present invention uses is one or more waxes selected from cera alba, candelila wax, palm vegetable wax or ceresine.
The wax that the present invention uses all is current market sales of product, such as by Shandong You Suo Chemical Industry Science Co., Ltd With the cera alba of trade name cera alba sale, the small candle tree sold with trade name candelila wax by Guangzhou rain and dew Chemical Co., Ltd. Wax, the ceresine sold with trade name ceresine by Shandong You Suo Chemical Industry Science Co., Ltd, by the excellent limited public affairs of rope chemical science and technology in Shandong Take charge of the palm vegetable wax sold with trade name palm vegetable wax.
Main function of the film forming agent in lip repair of the present invention is to be formed when using maintenance lipstick persistently Film, increase the flexibility, extensibility and elasticity of lipstick.
In the present invention, when other components are in the content range, if film former content is less than 1 parts by weight, The spreadability of lipstick can be made poor;If film former content is higher than 10 parts by weight, lipstick can be made excessively greasy;Therefore, it forms a film Agent content is that 1~10 parts by weight are feasible, preferably 2~8 parts by weight, more preferably 4~6 parts by weight.
The film forming agent that the present invention uses is one or more selected from Parleam, glycerin monostearate or polybutene Film forming agent.
The film forming agent that the present invention uses all is current market sales of product, such as limited by the excellent rope chemical science and technology in Shandong Company with trade name synthesis saualane sale Parleam, by standing grain major company of Britain with trade name stearic acid monoglyceride The glycerin monostearate of sale, the polybutene sold with trade name polybutene by Guangzhou Shang De Chemical Co., Ltd.s.
Main function of the moisturizer in lip repair of the present invention can be kept when using maintenance lipstick Moisture avoids epidermis from drying.
In the present invention, when other components are in the content range, if content of humectant is less than 5 parts by weight, Lipstick moisture retention can be caused poor;If content of humectant is higher than 10 parts by weight, the too soft and easy sweating of lipstick can be caused;Cause This, content of humectant is that 5~10 parts by weight are feasible, preferably 6~9 parts by weight, more preferably 7~8 parts by weight.
The moisturizer that the present invention uses is one or more moisturizer selected from vaseline, saualane or hyaluronic acid.
The moisturizer that the present invention uses all is current market sales of product, such as limited by the excellent rope chemical science and technology in Shandong Vaseline that company is sold with trade name vaseline sells the natural angle sold with trade name " saualane " by Nof Corp. Shark alkane, the hyaluronic acid sold with trade name hyaluronic acid by Shandong You Suo Chemical Industry Science Co., Ltd.
Main function of the emollients in lip repair of the present invention is that it can be allowed to be formed in skin surface is thin Protective layer makes skin enjoy the benefit of itself similar sebum, while can prevent water loss, gives required for dry skin Moisten.
In the present invention, when other components are in the content range, if soft and moist agent content is less than 1 parts by weight, Lipstick moistness can be made poor;If soft and moist agent content is higher than 15 parts by weight, lipstick can be made too soft;Therefore, soft and moist agent content is 1 ~15 parts by weight are suitable, preferably 4~12 parts by weight, more preferably 6~10 parts by weight.
The emollients that the present invention uses are one or more selected from octyl dodecanol, sad certain herbaceous plants with big flowers acid glycerol three ester or poly- diformazan The emollients of radical siloxane.
The emollients that the present invention uses all are current market sales of products, such as by the Guangzhou Chinese mugwort limited public affairs of bit trade Take charge of sold with trade name octyl dodecanol octyl dodecanol, by German Ying Chuan companies with trade name caprylic/capric triglyceride The caprylic/capric triglyceride of sale is sold by Shandong You Suo Chemical Industry Science Co., Ltd with trade name dimethyl silicone polymer Dimethyl silicone polymer.
Main function of the antioxidant in lip repair of the present invention be aided capture and in and free radical, from And it dispels free radical and human body is damaged.
In the present invention, when other components are in the content range, if oxidation preventive content is less than 0.1 weight Part, then it can make effect unobvious;If oxidation preventive content is higher than 0.5 parts by weight, lipstick cost can be increased;Therefore, antioxygen Agent content is that 0.1~0.5 parts by weight are appropriate, preferably 0.2~0.4 parts by weight, more preferably 0.2~0.3 weight Measure part.
The antioxidant that the present invention uses is one or more selected from tocopheryl acetate ethyl ester, grape seed oil or vitamin E Antioxidant.
The antioxidant that the present invention uses all is current market sales of product, such as is had by the excellent rope chemical science and technology in Shandong Tocopheryl acetate ethyl ester that limit company is sold with trade name tocopheryl acetate ethyl ester, by Guangzhou Chinese mugwort bit trade Co., Ltd with quotient The grape seed oil of name of an article grape seed oil sale, the dimension sold with trade name vitamin E by the Guangzhou bio tech ltd Zhong Hong Raw element E.
Main function of the preservative in lip repair of the present invention is to prevent microbial growth from causing grease rotten It loses and is ruptured with system.
In the present invention, when other components are in the content range, if antiseptic content is less than 0.05 parts by weight, Then anti-corrosion effect unobvious;If antiseptic content is higher than 0.1 parts by weight, there is side effect to skin;Therefore, antiseptic content It is feasible, preferably 0.06~0.08 parts by weight for 0.05~0.1 parts by weight.
The preservative that the present invention uses is one or more selected from butyl hydroxytoluene, the anti-corrosion of Phenoxyethanol or Nipasol Agent.
The preservative that the present invention uses all is current market sales of product, such as by Jining Heng Tai chemical companies with quotient The butyl hydroxytoluene of name of an article butyl hydroxytoluene sale is sold by Shandong You Suo Chemical Industry Science Co., Ltd with trade name Phenoxyethanol Phenoxyethanol, the Nipasol sold with trade name Nipasol by Beijing biochemical corp Sang Pu.
Main function of the essence in lip repair of the present invention is to confer to the certain fragrance of lipstick.
In the present invention, when other components are in the content range, if essence content is less than 0.1 parts by weight, Fragrance unobvious;If essence content is higher than 0.3 parts by weight, fragrance is too dense;Therefore, essence content is 0.1~0.3 parts by weight It is suitable, preferably 0.1~0.2 parts by weight.
The essence that the present invention uses is flavoring apple essence or peach flavor, they are current market sales of product, example The flavoring apple essence such as sold with trade name flavoring apple essence by Shandong You Suo Chemical Industry Science Co., Ltd, by the excellent rope chemical science and technology in Shandong The peach flavor that Co., Ltd is sold with trade name peach flavor.
The invention further relates to the preparation methods of the lip repair.
The step of preparation method, is as follows:
A, 30~50 parts by weight vegetable oil and 10~20 parts by weight hump fat heat in water-bath at 50-60 DEG C of temperature Dissolving, is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, 10~30 parts by weight waxes, 1~10 weight is added into the transparency liquid Part film forming agent, 5~10 parts by weight moisturizer and 1~15 parts by weight emollients, stir evenly;
C, the homogeneous mixture that step B is obtained vacuum outgas 1 under conditions of 85 DEG C of temperature and 0.02~0.08MPa of pressure Then it is anti-oxidant that 0.1~0.3 parts by weight essence, 0.05~0.1 parts by weight preservative and 0.1~0.5 parts by weight are added in~3min Agent is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the temperature that step C is obtained is 70~90 DEG C Mixture injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The case where in relation to hump fat, vegetable oil, wax, emollients, moisturizer, film forming agent, antioxidant, preservative and essence Oneself is through description in front, and details are not described herein.
The present invention prepares the equipment used when lip repair and is usually used, currently on the market in the art The equipment of sale.
[advantageous effect]
The beneficial effects of the invention are as follows:Lip repair of the present invention can promote lip tissue water content, keep lip more water tender, With excellent moist moistening effect, subcutaneous collagen protein content can be promoted, can not only prevent dry skin from cracking, moreover it is possible into The natural elasticity of skin is restored and kept to one step, has effects that preferable deep layer is moistened.What the present invention used is all natural material, Safe and non-toxic, good to the non-stimulated use feeling of skin, it is unique to make formula, lotion white color and it is bright, quality is fine and smooth, when using without Greasy feeling, lip is bright and full after smearing.
【Description of the drawings】
Fig. 1 is the measurement result of lip repair fusing point prepared by the embodiment of the present invention 1~4;
Fig. 2 is the Determination of Hardness result of lip repair prepared by the embodiment of the present invention 1~4;
Fig. 3 is the disruptive force measurement result of lip repair prepared by the embodiment of the present invention 1~4;
Fig. 4 is mouse ear thickness change figure;
Fig. 5 different time mouse ear moisture content change figures;
Fig. 6 different time mouse ear fat content variation diagrams;
Fig. 7 is normal group mouse ear histotomy figure;
Fig. 8 is modeling group mouse ear histotomy figure;
Fig. 9 is lipstick group mouse ear histotomy figure;
Figure 10 is vaseline group mouse ear histotomy figure;
Figure 11 is different component FLG average optical density values;
Figure 12 is different component INV average optical density values;
Figure 13 is that the pretherapy and post-treatment different time sections moisture of upper lip compares figure;
Figure 14 is that the pretherapy and post-treatment different time sections fat content of upper lip compares figure;
Figure 15 is that the pretherapy and post-treatment different time sections moisture of lower lip compares figure;
Figure 16 is that the pretherapy and post-treatment different time sections fat content of lower lip compares figure;
Figure 17 is the picture of lip when cracking resistance lip repair of the present invention is not used;
Figure 18 is the picture using lip when cracking resistance lip repair of the present invention 7th day;
Figure 19 is the picture using lip when cracking resistance lip repair of the present invention 15th day.
【Specific implementation mode】
The present invention is will be better understood that by following embodiments.
Embodiment 1:The preparation of lip repair of the present invention
The embodiment of the embodiment is as follows:
A, 30 parts by weight vegetable oil (+6 parts by weight of+8 parts by weight shea butter of+6 wt parts of olive oil of 10 parts by weight castor oil Jojoba oil) it is dissolved by heating at 55 DEG C of temperature in water-bath with 14 parts by weight hump fat, it is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, 16 parts by weight waxes (6 parts by weight cera albas is added into the transparency liquid + 3 parts by weight ceresine of+5 parts by weight palm vegetable wax of+2 wt parts Candelilla Wax), 6 parts by weight film forming agents (4 parts by weight of hydrogenated poly- isobutyls + 1 parts by weight of polybutene of+1 parts by weight glycerin monostearate of alkene), 10 parts by weight moisturizer (+2 parts by weight of 5 parts by weight vaseline + 3 parts by weight hyaluronic acid of saualane) and 1 parts by weight emollients (1 parts by weight octyl dodecanol), it stirs evenly;
C, the homogeneous mixture that step B is obtained vacuum outgas 1min under conditions of 85 DEG C of temperature and pressure 0.02MPa, so After 0.1 parts by weight essence (+0.05 parts by weight peach flavor of 0.05 weight of apple essence), 0.05 parts by weight fourth hydroxyl is added Toluene preservative and 0.1 parts by weight tocopheryl acetate ethyl ester antioxidant are uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the mixing that the temperature that step C is obtained is 70 DEG C Object injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The embodiment prepare cracking resistance lip repair physical and chemical index examine, resultant effect investigate experiment, it is both effectiveness experiment, The test results such as therapeutic evaluation see below test example part.
Embodiment 2:The preparation of lip repair of the present invention
The embodiment of the embodiment is as follows:
A, 36 parts by weight vegetable oil (oily+5 weights of+8 parts by weight Queensland nut seed of+12 wt parts of olive oil of 4 parts by weight castor oil + 7 parts by weight jojoba oil of amount part shea butter) it is dissolved by heating under temperature 50 C in water-bath with 10 parts by weight hump fat, It is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, 24 parts by weight waxes (8 parts by weight cera albas is added into the transparency liquid + 9 parts by weight ceresine of+5 parts by weight palm vegetable wax of+2 wt parts Candelilla Wax), 1 parts by weight film forming agent (0.5 parts by weight monostearate + 0.5 parts by weight of polybutene of glyceride), 5 parts by weight moisturizer (+3 parts by weight hyaluronic acid of 2 parts by weight vaseline) and 15 weight Part emollients (+8 parts by weight dimethyl silicone polymer of+5 parts by weight of octanoic acid certain herbaceous plants with big flowers acid glycerol three ester of 2 parts by weight octyl dodecanol), are stirred It mixes uniformly;
C, the homogeneous mixture that step B is obtained vacuum outgas 2min under conditions of 85 DEG C of temperature and pressure 0.04MPa, so After 0.3 parts by weight essence (+0.1 parts by weight peach flavor of 0.2 weight of apple essence), 0.1 parts by weight preservative is added (+0.2 parts by weight Nipasol of+0.4 parts by weight Phenoxyethanol of 0.4 parts by weight butyl hydroxytoluene) and 0.5 parts by weight antioxidant (+0.3 part by weight of vitamin E of 0.1+0.1 parts by weight grape seed oil of parts by weight tocopheryl acetate ethyl ester) is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the mixing that the temperature that step C is obtained is 80 DEG C Object injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The embodiment prepare cracking resistance lip repair physical and chemical index examine, resultant effect investigate experiment, it is both effectiveness experiment, The test results such as therapeutic evaluation see below test example part.
Embodiment 3:The preparation of lip repair of the present invention
The embodiment of the embodiment is as follows:
A, 44 parts by weight vegetable oil (oily+8 parts by weight shea butters of+12 parts by weight Queensland nut seed of 4 wt parts of olive oil+ The white pond flower seed oil of+4 parts by weight of 16 parts by weight jojoba oil) it is heated at 55 DEG C of temperature in water-bath with 20 parts by weight hump fat Dissolving, is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, 10 parts by weight waxes (1 parts by weight cera alba is added into the transparency liquid + 6 parts by weight ceresine of+3 parts by weight palm vegetable wax), (+2 parts by weight list of 4 parts by weight of hydrogenated polyisobutene is hard for 10 parts by weight film forming agents + 4 parts by weight of polybutene of glycerol), (1 parts by weight vaseline+4 parts by weight of+1 parts by weight saualane are saturating for 6 parts by weight moisturizer Bright matter acid) and 8 parts by weight emollients (+5 parts by weight dimethyl silicone polymer of 3 parts by weight octyl dodecanol), it stirs evenly;
C, the homogeneous mixture that step B is obtained vacuum outgas 3min under conditions of 85 DEG C of temperature and pressure 0.06MPa, so After 0.2 parts by weight essence (+0.05 parts by weight peach flavor of 0.15 weight of apple essence), 0.06 parts by weight preservative is added (0.02 parts by weight butyl hydroxytoluene++ 0.04 parts by weight Nipasol of parts by weight Phenoxyethanol) and 0.2 parts by weight antioxidant (+0.06 part by weight of vitamin E of 0.02+0.12 parts by weight grape seed oil of parts by weight tocopheryl acetate ethyl ester) is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the mixing at a temperature of 90 °C that step C is obtained Object injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The embodiment prepare cracking resistance lip repair physical and chemical index examine, resultant effect investigate experiment, it is both effectiveness experiment, The test results such as therapeutic evaluation see below test example part.
Embodiment 4:The preparation of lip repair of the present invention
The embodiment of the embodiment is as follows:
A, 50 parts by weight vegetable oil (oily+9 weights of+5 parts by weight Queensland nut seed of+6 wt parts of olive oil of 8 parts by weight castor oil Measure+10 white pond flower seed oil of parts by weight of part shea butter+12 parts by weight jojoba oil) with 18 parts by weight hump fat in water-bath It dissolves by heating, is stirred for transparency liquid under temperature 60 C;
B, above-mentioned water-bath is warming up to 85 DEG C, 30 parts by weight waxes (5 parts by weight cera albas is added into the transparency liquid + 11 parts by weight ceresine of+6 parts by weight palm vegetable wax of+8 wt parts Candelilla Wax), (1 is parts by weight of hydrogenated poly- different for 4 parts by weight film forming agents + 0.4 parts by weight of polybutene of+2.6 parts by weight glycerin monostearate of butylene), 8 parts by weight moisturizer (+2 weight of 4 parts by weight vaseline Measure+2 parts by weight hyaluronic acid of part saualane) (+4 parts by weight of octanoic acid certain herbaceous plants with big flowers of 2 parts by weight octyl dodecanol is sour with 12 parts by weight emollients + 6 parts by weight dimethyl silicone polymer of triglycerides), it stirs evenly;
C, the homogeneous mixture that step B is obtained vacuum outgas 2min under conditions of 85 DEG C of temperature and pressure 0.08MPa, so After 0.2 parts by weight essence (+0.1 parts by weight peach flavor of 0.1 weight of apple essence), 0.08 parts by weight preservative is added (+0.04 parts by weight Nipasol of+0.02 parts by weight Phenoxyethanol of 0.02 parts by weight butyl hydroxytoluene) is anti-oxidant with 0.4 parts by weight Agent (+0.2 part by weight of vitamin E of 0.1+0.1 parts by weight grape seed oil of parts by weight tocopheryl acetate ethyl ester) is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the mixing that the temperature that step C is obtained is 80 DEG C Object injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
The embodiment prepare cracking resistance lip repair physical and chemical index examine, resultant effect investigate experiment, it is both effectiveness experiment, The test results such as therapeutic evaluation see below test example part.
Test example 1:Physical and chemical index is examined
The test example carries out following several experiments:
1, character detects
The white solid of lip repair prepared by the present invention, viscosity is suitable, and hardness is suitable, the fine and smooth uniform, Tu Zhan of lotion Property it is good, the moist effect of anticracking can be played after, stability is good, pleasant aroma.
2, heat resistant test
Lip repair uncapping prepared by embodiment 1,2,3,4 all screws out, is vertically placed on 45 ± 1 DEG C of constant temperature of temperature In case for 24 hours, it takes out and restores to room temperature, the lip repair energy normal use, no softening, permeability phenomenon.
3 cold tests
Lip repair uncapping prepared by embodiment 1,2,3,4 all screws out, is vertically placed on -5-10 DEG C of refrigerators of temperature For 24 hours inside, it takes out and restores to room temperature, the lip repair energy normal use is impermeable, indeformable, not stratified.
4. centrefuge experiment
Lip repair prepared by embodiment 1,2,3,4 is packaged in tool plug test tube, in the condition of rotating speed 3000r/min Lower centrifugation 20min, no lamination.
5, stability test
Lip repair prepared by embodiment 1,2,3,4 is stood into investigation 3 months, no lamination, after at room temperature Feel unchanged, smell is unchanged.
6, irritant experiment, anaphylaxis experiment
Experiment small white mouse back is cut off into hair, respectively in the maintenance for cutting the plucked position smearing preparation of embodiment 1,2,3,4 Lip gloss, compared with the position that do not smear, the skin after smearing 30min does not have the irritations such as rubescent, dermexanthesis, blistering and mistake Quick reaction.
The volunteer that 30 ages are 16~50 years old is chosen, embodiment 1,2,3,4 is smeared in these volunteer's gesture and facial expressions and is made Standby lip repair is observed do not occur rubescent, dermexanthesis, foaming phenomena after 30 minutes.
7, lip repair fusing point of the present invention, hardness, disruptive force experiment
Fusing point, hardness, disruptive force are the fundamental characteristics of lipstick, they are mainly by the interaction institute between grease and wax class It determines.The too hard bad smearing of lipstick, it is too soft to be difficult to keep original shape.Lipstick fusing point is too low, and stability is bad, too high to influence The performance of lipstick.
(1) fusing point of presently commercially available lipstick, hardness and disruptive force measure
Current market sales of 20 kinds of lipsticks are carried out below to the measurement of fusing point, hardness, disruptive force, fusing point is basis What animal fat fusing point test GB/T12766-2008 standard methods measured;Hardness is that the hardness of lipstick is measured according to Texture instrument Lipstick is cut to the cube of 1.21cm × 1.21cm × 0.5cm (length × width × height) by method come what is measured, and speed is before surveying 1mm/s, survey medium velocity are 1mm/s, and speed is 1mm/s after survey, and target pattern is strain, and strain value selection 80% triggers pattern It is automatic;Disruptive force is measured according to the method for the shearing force of Texture instrument measurement lipstick, and lipstick is put into same mold In keep lipstick size the same, survey before speed be 1mm/s, surveys medium velocity be 1mm/s, after survey speed be 1mm/s, target pattern is position It moves, shift value selects 20mm, and triggering pattern is automatic.Its measurement result is listed in Table 1 below.
Table 1:The fusing point of 20 kinds of commercially available lipsticks, the measurement result of hardness and disruptive force
The result of table 1 clearly illustrates that these lipstick fusing points are 50~71 DEG C, and average value is 61.69 DEG C.These lipsticks are hard Degree is 308.8~1744.6HB, average value 817.17HB.These lipstick disruptive forces are 156.9~652.6N, and average value is 370.69N。
(2) lip repair fusing point test of the present invention
The fusing point that embodiment 1-4 prepares lip repair is determined according to above-mentioned standard assay method, the results are shown in attached In Fig. 1.Known by the result of attached drawing 1, embodiment 1-4 prepares the fusing point of lip repair within the scope of 50~71 DEG C, and above-mentioned Market survey result is consistent, hence it is demonstrated that this 4 kinds of lip repair meet general lipstick fusing point requirement.
(3) lip repair Determination of Hardness of the present invention
The hardness that embodiment 1-4 prepares lip repair is determined according to above-mentioned standard assay method, the results are shown in attached In Fig. 2.Being known by the result of attached drawing 2, embodiment 1-4 prepares the hardness of lip repair within the scope of 308.8~744.6N, with Above-mentioned market survey result is consistent, hence it is demonstrated that this 4 kinds of lip repair meet general lipstick hardness requirement.
(4) lip repair disruptive force of the present invention measures
Lipstick breaking degree reflects the hardness of lipstick indirectly, and lipstick is really up to the mark to will have a direct impact on its stretchability.According to above-mentioned mark Quasi- assay method determines the disruptive force that embodiment 1-4 prepares lip repair, and the results are shown in attached drawing 3.By the knot of attached drawing 3 Fruit knows that embodiment 1-4 prepares the disruptive force of lip repair in 156.9~652.6 ranges, with above-mentioned market survey result Unanimously, hence it is demonstrated that this 4 kinds of lip repair meet general lipstick disruptive force requirement.
Test example 2:Resultant effect is investigated
Using opinion poll point system, the people of 30 20~50 years old age brackets is chosen as object is tried out, arbitrarily by them Four groups are divided into, the embodiment 1-4 lip repair prepared is applied at lip respectively, usage time is one week, applies 3 within one day It is secondary.Using effect total score is 5 grades:Best result 5 divides, and indicates fine, very satisfied;4 points are preferable;3 points are that can receive; 3 points or less are bad, cannot be received.Every group of average results are listed in Table 2 below.
Table 2:Comprehensive performance scores
The result of table 2 clearly illustrates, can promote lip tissue water content using lip repair of the present invention, reduce epidermis Creeping phenomenon plays desalination cheilogramma, promotes lip elasticity and brightness, no greasy feeling.Lip repair of the present invention is also to lip simultaneously Portion is dry and cracked therapeutic effect.
In conclusion lip repair of the present invention is goodlooking, oiliness is moderate, and lotion is fine and smooth uniformly, stretchability is good, after Trap is good, moistens moisturizing, and stability is good, pleasant aroma, there is good cracking resistance maintenance effect.
Test example 3:The both effectiveness experiment of lip repair of the present invention
There is anti-inflammatory, cracking resistance and other effects to verify lip repair of the present invention, use it for suffering from chronic dermatitis BALB/c It at the ear of mouse, is smeared twice, is smeared 20 days with equal amount daily, observe its action and efficacy and mouse ear skin tissue disease Reason variation and immunohistochemistry.
The experiment sets normal group, modeling group and treatment group, and normal group is tested with no modeling and processed mouse; Modeling group to suffer from chronic dermatitis mouse, tested by the mouse for not making any treatment but;Treatment group is small to suffer from chronic dermatitis Mouse, the mouse treated using lip repair of the present invention are tested, including vaseline group;
The both effectiveness testing inspection ear thickness of test mice, ear moisture and ear fat content.Ear Thickness is the thickness that mouse ear is measured according to micrometer caliper, every time in the upper limb of the same location detection Mice Auricle of mouse, every 4 It measures primary standard method detection;Ear moisture be use by Ka Kushang silica gel Electronics Co., Ltd. of Shenzhen with Trade name digital skin moisture detector sale digital skin moisture detector, respectively before the treatment, treatment 10 days, treatment 20 It surveys mouse ear skin lesion moisture, and all detections are being detected at room temperature for 50%-60% in humidity;Ear grease contains Amount is using the digital skin sold with trade name digital skin moisture detector by Ka Kushang silica gel Electronics Co., Ltd. of Shenzhen Skin moisture detector, respectively before the treatment, treatment 10 days, treatment 20 days survey mouse ear skin lesion fat content, it is all detection wet Degree is being detected at room temperature for 50%-60%;These test results are listed in attached drawing 4-6.
Fig. 4 is the ear thickness variation diagram of different tests group test mice;Fig. 5 is different tests group test mice in difference The ear moisture content change figure of time;Fig. 6 is that different tests group test mice changes in the ear fat content of different time Figure;It can be seen from attached drawing 4-6 at the 14th day, mouse modeling is successful on the whole, and suffers from chronic dermatitis, starts to smear the present invention Lip repair and vaseline carry out comparison treatment, it can be seen from attached drawing 4 after smearing lip repair of the present invention, mouse Ear thickness is controlled, and is gradually tended towards stability.It can see by attached drawing 5 and Fig. 6, at the 14th day, due to mouse illness Cause mouse moisture and fat content smaller than normally organizing, after smearing lip repair of the present invention 34 days, it will be apparent that see mouse Moisture and fat content with normally organize it is almost the same, it can be seen that, lip repair of the present invention has centainly chronic dermatitis disease Alleviation and therapeutic efficiency.
In the present invention, test mice ear tissue slice is to cut mouse ear from root after being put to death according to mouse, Overnight, dehydration is fixed with 4% neutral formic acid, transparent, waxdip, wrapped later with paraffin after being cleaned in 85% physiological saline Slice (5 μm of thickness), HE dyeing are buried, the standard method of tissues observed pathological change situation under an optical microscope carries out.This The test mice ear tissue slice of a little different tests groups is listed in attached drawing 7-10.
Fig. 7 is normal group mouse ear histotomy figure;Fig. 8 is modeling group mouse ear histotomy figure;Fig. 9 is lipstick Group mouse ear histotomy figure;Figure 10 is vaseline group mouse ear histotomy figure;It is normal it can be seen from attached drawing 7-10 Mouse ear skin histology structure understands that well arranged, epidermal thickness is normal, and intracellular and iuntercellular is without oedema, without apparent Lymphocytic infiltration.Mouse ear epidermis thickens after modeling, it is seen that intracellular and intercellular edema, the big amount lymphocyte of high dermis Infiltration.After lip repair of the present invention and vaseline treatment, mouse ear tissue epidermis thickened degree reduces, epidermis and corium water It is swollen substantially reduced, show that lip repair and vaseline of the present invention have the function for the treatment of murine chronic dermatitis.
In the present invention, test mice cuts mouse ear from root after putting to death, a concentration of by weight 85% Cleaned in physiological saline, fix in a concentration of 4% paraformaldehyde solution by weight, paraffin embedding, slice, dewaxing;In concentration To be placed at room temperature for 5-10 minutes in 3% hydrogenperoxide steam generator by weight, antigen retrieval, Mianyang serum closing incubates primary antibody, incubates two Anti-, PBS washings, DAB colour developings are dehydrated transparent mounting, lead to mouse tissue K6, intermediate filament protein (FLG), involucrin (INV) Expression, to judge that the development and change situation of the state of an illness, situation of change are listed in attached drawing 11-12.
Figure 11 is different component FLG average optical density values;Figure 12 is different component INV average optical density values;By attached drawing 11 As can be seen that the average optical density value of normal group FLG is larger, the average optical density value of FLG is smaller at model group skin lesion, through this hair After bright lip repair and vaseline treatment, the average optical density value of FLG is larger, normally organizes INV's it can be seen from attached drawing 12 Average optical density value is larger, and the average optical density value of INV is smaller at model group skin lesion, through lip repair of the present invention and vaseline After treatment, the average optical density value of INV is larger.The expression of differentiation of intermediate filament protein (FLG) and involucrin (INV) and skin screen Barrier has close contact, and the patient of FLG protein I NV protein deficiencies is lost in increase through transepidermal water and cuticula aquation subtracts It is few, the anaphylactogen in environment can be made to be easier in intrusive body, so as to cause a series of immune responses, moisten lip through maintenance of the present invention After cream and vaseline treatment, the average optical density value of mouse FLG and INV increase, and show lip repair and vaseline of the present invention Have the function for the treatment of murine chronic dermatitis.
Test example 4:Lip repair therapeutic evaluation of the present invention
The embodiment of the test example is as follows:
Subjects:20 trial volunteers, women, 25~60 years old age.Their clinical manifestation is that lip easily occurs The subjective symptoms such as drying, furfur, chap.
Test method:Using the experiment of different time sections own control before and after treatment.
Upperlip moisture is measured according to using the standard method of pretherapy and post-treatment different time sections own control, upperlip Fat content is measured according to using the standard method of pretherapy and post-treatment different time sections own control.
Method of administration:Subject's external application lip repair of the present invention, every subject are applied to up and down according to 2 times/day Lip, before use, after use the 7th day and the 15th day 3 times record upperlip moisture and fat content.These test results are listed in In attached drawing 13-16.
Known by attached Figure 13 and 14 the results of analysis of variance, 13 upper lip of attached drawing treats p<0.05,14 upper lip of attached drawing treats p< 0.05, attached drawing 13 and attached drawing 14 all have statistical significance, i.e., have difference using front and back, can be with using lip repair of the present invention Improve the content of upper lip moisture and grease.
Known by attached drawing 15 and 16 the results of analysis of variance, 15 lower lip of attached drawing treats p<0.05,16 lower lip of attached drawing treats p< 0.05, attached drawing 15 and attached drawing 16 all have statistical significance, i.e., have difference using front and back, can be with using lip repair of the present invention Improve the content of lower lips moisture and grease.
It can be seen that lip repair of the present invention can significantly improve the moisture and fat content of entire lip.
Figure 17 is the photo of lip when lip repair of the present invention is not used;Figure 18 is using lip repair of the present invention the Lip photo at 7 days;Figure 19 is using lip photo when lip repair of the present invention 18th day.It can be clear by these photo comparisons Chu finds out can effectively treat cheilosis using lip repair of the present invention.

Claims (10)

1. a kind of having effects that the lip repair of cracking resistance, it is characterised in that the composition of the lip repair is as follows:With parts by weight Meter
2. lip repair according to claim 1, it is characterised in that the vegetable oil is one or more selected from castor The vegetable oil of sesame oil, olive oil, Queensland nut seed oil, shea butter, jojoba oil or white pond flower seed oil.
3. lip repair according to claim 1, it is characterised in that the wax be it is one or more selected from cera alba, The wax of candelila wax, palm vegetable wax or ceresine.
4. lip repair according to claim 1, it is characterised in that the emollients are one or more selected from pungent The emollients of base lauryl alcohol, sad certain herbaceous plants with big flowers acid glycerol three ester or dimethyl silicone polymer.
5. lip repair according to claim 1, it is characterised in that the moisturizer is one or more selected from all Intellectual circle, saualane or hyaluronic acid moisturizer.
6. lip repair according to claim 1, it is characterised in that the antioxidant is one or more is selected from The antioxidant of tocopheryl acetate ethyl ester, grape seed oil or vitamin E.
7. lip repair according to claim 1, it is characterised in that the film forming agent is one or more selected from hydrogen Change the film forming agent of polyisobutene, glycerin monostearate or polybutene.
8. lip gloss according to claim 1, it is characterised in that the preservative is one or more selected from fourth hydroxyl The preservative of toluene, Phenoxyethanol or Nipasol.
9. lip gloss according to claim 1, it is characterised in that the essence is flavoring apple essence or peach flavor.
10. the preparation method of the lip repair according to any one of claim 1-9 claims, it is characterised in that should The step of preparation method, is as follows:
A, 30~50 parts by weight vegetable oil and 10~20 parts by weight hump fat heat in water-bath at 50-60 DEG C of temperature molten Solution, is stirred for transparency liquid;
B, above-mentioned water-bath is warming up to 85 DEG C, into the transparency liquid add 10~30 parts by weight waxes, 1~10 parts by weight at Film, 5~10 parts by weight moisturizer and 1~15 parts by weight emollients, stir evenly
C, the homogeneous mixture that step B is obtained under conditions of 85 DEG C of temperature is with 0.02~0.08MPa of pressure vacuum outgas 1~ Then it is anti-oxidant that 0.1~0.3 parts by weight essence, 0.05~0.1 parts by weight preservative and 0.1~0.5 parts by weight are added in 3min Agent is uniformly mixed;
D, Rouge mold is preheated to 35 DEG C with Rouge mold warm table, the mixing that the temperature that step C is obtained is 70~90 DEG C Object injects in Rouge mold, then cools to room temperature, then tubulature, obtains the lip repair.
CN201810561195.5A 2018-06-04 2018-06-04 A kind of lip repair and preparation method thereof with cracking resistance Pending CN108403610A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109528519A (en) * 2018-12-06 2019-03-29 深圳市美福源日用品有限公司 A kind of lipstick and preparation method thereof
CN110251410A (en) * 2019-05-13 2019-09-20 广东蕾琪化妆品有限公司 A kind of lipstick and preparation method thereof according to the colour developing of human body acid-base value
CN110693782A (en) * 2019-11-04 2020-01-17 广州品赫化妆品有限公司 Lipstick rich in composite repairing composition and preparation method thereof
CN111317809A (en) * 2020-04-02 2020-06-23 新疆医科大学 Camel peak compound ointment and preparation method and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140248370A1 (en) * 2013-03-04 2014-09-04 Abdulkadir Hashi Ali Enhancement Composition
WO2014135934A1 (en) * 2013-03-07 2014-09-12 Applied Bio Research Inc. Camelid compound(s), composition(s) and method(s)
CN104784073A (en) * 2015-03-27 2015-07-22 李大兴 Lip repairing and moistening cream containing horse oil and preparation method of lip repairing and moistening cream
CN105106098A (en) * 2015-09-29 2015-12-02 新疆旺源驼奶实业有限公司 Composition for preparing camel milk facial mask and preparation method thereof
CN105997584A (en) * 2016-05-27 2016-10-12 江西联锴新材料有限公司 Camellia oleosa seed oil repairing lipstick and preparation method thereof
CN107519125A (en) * 2017-10-12 2017-12-29 广州番禺职业技术学院 One kind has moisturizing effect lipstick and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140248370A1 (en) * 2013-03-04 2014-09-04 Abdulkadir Hashi Ali Enhancement Composition
WO2014135934A1 (en) * 2013-03-07 2014-09-12 Applied Bio Research Inc. Camelid compound(s), composition(s) and method(s)
CN104784073A (en) * 2015-03-27 2015-07-22 李大兴 Lip repairing and moistening cream containing horse oil and preparation method of lip repairing and moistening cream
CN105106098A (en) * 2015-09-29 2015-12-02 新疆旺源驼奶实业有限公司 Composition for preparing camel milk facial mask and preparation method thereof
CN105997584A (en) * 2016-05-27 2016-10-12 江西联锴新材料有限公司 Camellia oleosa seed oil repairing lipstick and preparation method thereof
CN107519125A (en) * 2017-10-12 2017-12-29 广州番禺职业技术学院 One kind has moisturizing effect lipstick and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109528519A (en) * 2018-12-06 2019-03-29 深圳市美福源日用品有限公司 A kind of lipstick and preparation method thereof
CN110251410A (en) * 2019-05-13 2019-09-20 广东蕾琪化妆品有限公司 A kind of lipstick and preparation method thereof according to the colour developing of human body acid-base value
CN110693782A (en) * 2019-11-04 2020-01-17 广州品赫化妆品有限公司 Lipstick rich in composite repairing composition and preparation method thereof
CN111317809A (en) * 2020-04-02 2020-06-23 新疆医科大学 Camel peak compound ointment and preparation method and application thereof

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