CN109020835A - 一种医药中间体沙坦联苯的制备方法 - Google Patents
一种医药中间体沙坦联苯的制备方法 Download PDFInfo
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- CN109020835A CN109020835A CN201811282949.XA CN201811282949A CN109020835A CN 109020835 A CN109020835 A CN 109020835A CN 201811282949 A CN201811282949 A CN 201811282949A CN 109020835 A CN109020835 A CN 109020835A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/20—Diazonium compounds
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
Description
实施例 | 选择性 | 收率 | 反应时间/min |
1 | 90.2% | 87.2% | 8.5 |
2 | 94.3% | 90.8% | 8.9 |
3 | 91.2% | 85.6% | 7.3 |
4 | 93.3% | 88.2% | 9.2 |
5 | 90.8% | 91.1% | 5.7 |
6 | 94.3% | 90.3% | 5.9 |
7 | 95.6% | 92.1% | 4.2 |
8 | 92.4% | 89.1% | 6.3 |
9 | 92.6% | 88.5% | 8.2 |
10 | 93.9% | 91.5% | 6.9 |
11 | 92.8% | 91.8% | 7.1 |
12 | 91.4% | 86.2% | 5.4 |
Claims (8)
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CN201811282949.XA CN109020835B (zh) | 2018-10-31 | 2018-10-31 | 一种医药中间体沙坦联苯的制备方法 |
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CN201811282949.XA CN109020835B (zh) | 2018-10-31 | 2018-10-31 | 一种医药中间体沙坦联苯的制备方法 |
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CN109020835A true CN109020835A (zh) | 2018-12-18 |
CN109020835B CN109020835B (zh) | 2021-11-16 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09176104A (ja) * | 1995-12-27 | 1997-07-08 | Mikuni Seiyaku Kogyo Kk | アリールベンゾニトリルの製造法 |
JPH11171802A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | アルキルビフェニル誘導体の製造法およびその中間体 |
JPH11171799A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | 活性置換基を有するビフェニル誘導体の製造法 |
CN107663160A (zh) * | 2016-07-27 | 2018-02-06 | 上海惠和化德生物科技有限公司 | 一种4‑氯苯肼盐的连续流合成工艺 |
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2018
- 2018-10-31 CN CN201811282949.XA patent/CN109020835B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09176104A (ja) * | 1995-12-27 | 1997-07-08 | Mikuni Seiyaku Kogyo Kk | アリールベンゾニトリルの製造法 |
JPH11171802A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | アルキルビフェニル誘導体の製造法およびその中間体 |
JPH11171799A (ja) * | 1997-12-08 | 1999-06-29 | Mikuni Seiyaku Kogyo Kk | 活性置換基を有するビフェニル誘導体の製造法 |
CN107663160A (zh) * | 2016-07-27 | 2018-02-06 | 上海惠和化德生物科技有限公司 | 一种4‑氯苯肼盐的连续流合成工艺 |
Non-Patent Citations (3)
Title |
---|
GANESH U. CHATURBHUJ 等: "Copper catalyzed Gomberg–Buchmann–Hey reaction using aryldiazonium tosylate", 《TETRAHEDRON LETTERS》 * |
XINGYI ZHU 等: "Copper-catalyzed cross-coupling of arenediazonium tetrafluoroborates with polyfluoroarenes", 《TETRAHEDRON LETTERS》 * |
计燕萍 等: "一种合成多氟联苯类化合物的新方法", 《合成化学》 * |
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CN109020835B (zh) | 2021-11-16 |
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Effective date of registration: 20211102 Address after: 150000 room 430, life medicine entrepreneurship building, Limin biomedical R & D center, East Shenyang Street and South Zhuhai Road, Limin Development Zone, Harbin, Heilongjiang Province Applicant after: Harbin bullfighting Biotechnology Co.,Ltd. Address before: 350200 1 Beihu village, Gu Huai Town, Changle City, Fuzhou, Fujian Applicant before: FUZHOU SHENGSHI LINGYUN ENVIRONMENTAL PROTECTION TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20221212 Address after: Room 317, Life Medicine Venture Building, Limin Biomedical R&D Center, East Shenyang Street and South Zhuhai Road, Limin Development Zone, Harbin, Heilongjiang, 150000 Patentee after: HARBIN ZHENJUNDI BIOPHARMACEUTICAL TECHNOLOGY Co.,Ltd. Address before: 150000 room 430, life medicine entrepreneurship building, Limin biomedical R & D center, East Shenyang Street and South Zhuhai Road, Limin Development Zone, Harbin, Heilongjiang Province Patentee before: Harbin bullfighting Biotechnology Co.,Ltd. |