CN108938509A - Anti-dandruff and itching-relieving composition and preparation method thereof and its application - Google Patents
Anti-dandruff and itching-relieving composition and preparation method thereof and its application Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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Abstract
The present invention relates to a kind of anti-dandruff and itching-relieving compositions and preparation method thereof and its application.According to mass percentage meter, the raw material for preparing above-mentioned anti-dandruff and itching-relieving composition includes following component: must extractive of usnea 3%~30%, agastache extract 5%~20%, Fructus Kochiae extract 2%~20%, Radix Gentianae extract 1%~25%, propylene glycol 30%~65% and deionized water 5%~30%.The active constituent that the control anti-dandruff and itching-relieving closes in object comes all from plant extracts, smaller to human body irritation, and experiment proves that the anti-dandruff and itching-relieving composition has the effect of anti-dandruff and itching-relieving.
Description
Technical field
The present invention relates to daily chemical product fields, answer more particularly to a kind of anti-dandruff and itching-relieving composition and preparation method thereof with it
With.
Background technique
Adjunct of the hair as skin is not only able to maintain heat, but also has certain modification, is the important set of human body
At part.The study found that at home, 60% adult is to some extent by the puzzlement of dandruff, and this is mainly due to states
Interior consumer is not paid attention to skin of head health care or is washed caused by hair products using inappropriate.
And it is essentially all ZPT, climbazole that anti-dandruff on domestic market, which washes anti-dandruff and itching-relieving agent used by shield product,
Etc. artificial synthesized chemical substance.Although these substances all have certain anti-dandruff and itching-relieving effect, there is certain thorns
Swash property, scalp may be influenced by being used for a long time, and cause other hair problems.
Summary of the invention
Based on this, it is necessary to provide a kind of lesser anti-dandruff and itching-relieving composition of irritation.
In addition, also providing the preparation method and its application of a kind of above-mentioned anti-dandruff and itching-relieving composition.
A kind of anti-dandruff and itching-relieving composition prepares the raw material packet of the anti-dandruff and itching-relieving composition according to mass percentage meter
Include following component:
It must extractive of usnea 3%~30%, agastache extract 5%~20%, Fructus Kochiae extract 2%~20%, rough gentian
Extract 1%~25%, propylene glycol 30%~65% and deionized water 5%~30%.
Active constituent in above-mentioned anti-dandruff and itching-relieving composition is all from plant extracts, smaller to human body irritation, and
Experiment proves that the anti-dandruff and itching-relieving composition has the effect of anti-dandruff and itching-relieving.
The palpus extractive of usnea is the supercritical CO of palpus sunglo in one of the embodiments,2Extract, the wrinkled giant hyssop
Extract is the supercritical CO of wrinkled giant hyssop2Extract, the supercritical CO that the Fructus Kochiae extract is the fruit of summer cypress2Extract, the dragon
Gall extract is the supercritical CO of rough gentian2Extract.
In one of the embodiments, according to mass percentage meter, the raw material packet of the anti-dandruff and itching-relieving composition is prepared
Include following component:
It must extractive of usnea 20%, agastache extract 10%, Fructus Kochiae extract 10%, Radix Gentianae extract 10%, the third two
Alcohol 40% and deionized water surplus.
A kind of preparation method of above-mentioned anti-dandruff and itching-relieving composition, includes the following steps:
By the water and mixed with propylene glycol and 75 DEG C~85 DEG C are heated to, stirring 25min~35min；
The palpus extractive of usnea, agastache extract, Fructus Kochiae extract and Radix Gentianae extract, stirring to each component is added
Dissolution, obtains anti-dandruff and itching-relieving composition.
Further include in one of the embodiments, it is described must the preparation step of extractive of usnea, the agastache extract
The preparation step of preparation step, the preparation step of the Fructus Kochiae extract and the Radix Gentianae extract:
It is described must extractive of usnea preparation step are as follows: must sunglo crush, sieving, obtain palpus sunglo powder；Faced with super
Boundary CO2Fluid extracts the palpus sunglo powder, and obtaining must sunglo extraction mixture；Mixture is extracted to the palpus sunglo
It is separated, obtaining must sunglo isolate；The palpus sunglo isolate and water are mixed and carry out heating distillation extraction, after condensation
To palpus extractive of usnea；
The preparation step of the agastache extract are as follows: wrinkled giant hyssop is crushed, sieving, obtain Wrinkled Gianthyssop Herb；Use supercritical CO2Stream
Body extracts the Wrinkled Gianthyssop Herb, obtains wrinkled giant hyssop extraction mixture；Wrinkled giant hyssop extraction mixture is separated, is obtained
Wrinkled giant hyssop isolate；The wrinkled giant hyssop isolate and water are mixed and carry out heating distillation extraction, obtains agastache extract after condensation；
The preparation step of the Fructus Kochiae extract are as follows:
The fruit of summer cypress is crushed, sieving, obtains Belvedere Fruit；Use supercritical CO2Fluid carries out the Belvedere Fruit
Extraction obtains fruit of summer cypress extraction mixture；Fruit of summer cypress extraction mixture is separated, fruit of summer cypress root isolate is obtained；
The fruit of summer cypress isolate and water are mixed and carry out heating distillation extraction, obtains Fructus Kochiae extract after condensation；And
The preparation step of the Radix Gentianae extract are as follows: rough gentian is crushed, sieving, obtain rough gentian powder；Use supercritical CO2Stream
Body extracts the rough gentian powder, obtains rough gentian extraction mixture；Rough gentian extraction mixture is separated, is obtained
Rough gentian isolate；The rough gentian isolate and water are mixed and carry out heating distillation extraction, obtains Radix Gentianae extract.
The aperture of sieve is greater than or equal to 300 mesh in the step of sieving in one of the embodiments,.
It is described in one of the embodiments, to use supercritical CO2CO in the step of extraction2Flow velocity is 1.5kg/h~8kg/
H, extracting pressure are 15MPa~25MPa, and extraction temperature is 35 DEG C, extraction time 5h.
Separating pressure is 4MPa~6MPa, separation temperature 38 in the step of separation in one of the embodiments,
DEG C~40 DEG C, disengaging time is 4h~6h.
In one of the embodiments, in the step of distillation extraction, the solid-liquid ratio of the isolate and the water is
1g/L~5g/L, distillation time are 6h~8h.
Above-mentioned anti-dandruff and itching-relieving composition is preparing the application in hair washing product or hair products.
Detailed description of the invention
Fig. 1 is the flow chart of the preparation method of the anti-dandruff and itching-relieving composition of an embodiment；
Fig. 2 is the flow chart of the preparation method of the palpus extractive of usnea of an embodiment.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give preferred embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, purpose of providing these embodiments is keeps the understanding to the disclosure more saturating
It is thorough comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The anti-dandruff and itching-relieving composition of one embodiment prepares the original of anti-dandruff and itching-relieving composition according to mass percentage meter
Material includes following component:
It must extractive of usnea 3%~30%, agastache extract 5%~20%, Fructus Kochiae extract 2%~20%, rough gentian
Extract l%~25%, propylene glycol 30%~65% and deionized water 5%~30%.
In one of the embodiments, must extractive of usnea be must sunglo supercritical CO2Extract, agastache extract are
The supercritical CO of wrinkled giant hyssop2Extract, the supercritical CO that Fructus Kochiae extract is the fruit of summer cypress2Extract, Radix Gentianae extract are rough gentian
Supercritical CO2Extract.It is appreciated that active constituent of the above-mentioned four kinds of extracts as anti-dandruff and itching-relieving composition, all is from
In plant, performance is mild, stimulates human body smaller.
In one of the embodiments, according to mass percentage meter, the raw material for preparing anti-dandruff and itching-relieving composition includes such as
Lower component:
It must extractive of usnea 20%, agastache extract 10%, Fructus Kochiae extract 10%, Radix Gentianae extract 10%, the third two
Alcohol 40% and deionization deionized water surplus.
Active constituent in above-mentioned anti-dandruff and itching-relieving composition is all from plant extracts, smaller to human body irritation, through trying
Verifying has the effect of anti-dandruff and itching-relieving.
As shown in Figure 1, the preparation method of the anti-dandruff and itching-relieving composition of an embodiment, includes the following steps:
Step S110: by above-mentioned water and mixed with propylene glycol and 75 DEG C~85 DEG C are heated to, stirring 25min~35min.
Step S120: above-mentioned palpus extractive of usnea, agastache extract, Fructus Kochiae extract and Radix Gentianae extract is added, stirs
It mixes to each component and dissolves, obtain anti-dandruff and itching-relieving composition.
Wherein, water and propylene glycol are solvent, and propylene glycol has the function of antibiotic effect.Must extractive of usnea as antibacterial at
Point.Palpus sunglo plays the role of very strong antibacterial and antiprotozoan, and the antibacterial action of contained usnic acid is especially prominent, there is clearing liver, changes
Phlegm, hemostasis, removing toxic substances are used.Agastache extract, can be antimycotic as another antimicrobial component.Fructus Kochiae extract stops as antibacterial
Itch ingredient, have the function of antimycotic, antipruritic, is able to maintain the good growing environment of hair follicle.Radix Gentianae extract is as antipruritic anti-inflammatory
Ingredient, have the function of it is antipruritic, analgesia, it is anti-inflammatory.
As shown in Fig. 2, in one of the embodiments, further including the preparation step of palpus extractive of usnea, agastache extract
Preparation step, the preparation step of the preparation step of Fructus Kochiae extract and Radix Gentianae extract:
Wherein, the preparation step of palpus extractive of usnea are as follows:
Step S121: must sunglo crush, sieving, obtaining must sunglo powder.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
Step S122: supercritical CO is used2Fluid extracts palpus sunglo powder, and obtaining must sunglo extraction mixture.
Wherein, supercritical CO2Flow velocity is 1.5kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is
35 DEG C, extraction time 5h.
Step S123: palpus sunglo extraction mixture is separated, obtaining must sunglo isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
Step S124: must sunglo isolate add water mixing to carry out heating distillation extraction, obtaining must extractive of usnea.
Wherein, palpus sunglo isolate and water solid-liquid ratio are 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of agastache extract:
(1) wrinkled giant hyssop is crushed, sieving, obtains Wrinkled Gianthyssop Herb.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts Wrinkled Gianthyssop Herb, obtains wrinkled giant hyssop extraction mixture.
Wherein, supercritical CO2Flow velocity is 1.5kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is
35 DEG C, extraction time 5h.
(3) wrinkled giant hyssop extraction mixture is separated, obtains wrinkled giant hyssop isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) add water to mix wrinkled giant hyssop isolate to carry out heating distillation extraction, obtain agastache extract.
Wherein, wrinkled giant hyssop isolate and water solid-liquid ratio are 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of Fructus Kochiae extract:
(1) fruit of summer cypress is crushed, sieving, obtains Belvedere Fruit.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts Belvedere Fruit, obtains fruit of summer cypress extraction mixture.
Wherein, supercritical CO2Flow velocity is 1.5kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is
35 DEG C, extraction time 5h.
(3) fruit of summer cypress extraction mixture is separated, obtains fruit of summer cypress isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) add water to mix fruit of summer cypress isolate to carry out heating distillation extraction, obtain Fructus Kochiae extract.
Wherein, fruit of summer cypress isolate and water solid-liquid ratio are 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of Radix Gentianae extract:
(1) rough gentian is crushed, sieving, obtains rough gentian powder.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts rough gentian powder, obtains rough gentian extraction mixture.
Wherein, supercritical CO2Flow velocity is 1.5kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is
35 DEG C, extraction time 5h.
(3) rough gentian extraction mixture is separated, obtains rough gentian isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) add water to mix rough gentian isolate to carry out heating distillation extraction, obtain Radix Gentianae extract.
Wherein, rough gentian isolate and water solid-liquid ratio are 1g/L~5g/L, and distillation time is 6h~8h.
It should be noted that passing through advanced supercritical CO2The above-mentioned plant extracts that extraction process extracts, work therein
Property ingredient retains more, and impurity is less, and effect is more preferable than the effect of traditional boiling type extract.
Above-mentioned anti-dandruff and itching-relieving composition is combined according to the anti-dandruff and itching-relieving that anti-dandruff and itching-relieving preparation method of composition is prepared
Object is preparing the application in hair washing product or hair products.
The hair washing product as made from above-mentioned anti-dandruff and itching-relieving composition or hair products have effects that anti-dandruff and itching-relieving, and right
Human body irritation is smaller.
The following are specific embodiment part, (following embodiment unless otherwise specified, does not then contain and removes inevitable impurity
Other components not yet explicitly pointed out in addition), table 1 is the percentage composition of Examples 1 to 5 and comparative example each component, and table 2 is each reality
Apply technological parameter when prepared plant extracts in example and comparative example.
Embodiment 1
The preparation step of the anti-dandruff and itching-relieving composition of the present embodiment is as follows:
(1) according to percentage composition listed by table 1, deionized water and mixed with propylene glycol is weighed and is heated to 75 DEG C~85
DEG C, stir 25min~35min.
(2) palpus extractive of usnea, agastache extract, Fructus Kochiae extract and the dragon of percentage composition listed by table 1 is added
Gall extract, stirring to each component are dissolved, and anti-dandruff and itching-relieving composition is obtained.
The percentage composition of 1 Examples 1 to 5 of table and each raw material of comparative example
Wherein, the preparation step of palpus extractive of usnea is as follows:
(1) must sunglo crush, cross 300 mesh screens, obtaining must sunglo powder.
(2) supercritical CO for being 1.5kg/h with flow velocity2Fluid extracts palpus sunglo powder, and obtaining must sunglo extraction
Mixture.
Wherein, extracting pressure 15MPa, extraction temperature are 35 DEG C, extraction time 5h.
(3) it is 4MPa in separating pressure, under the conditions of separation temperature is 38 DEG C, palpus sunglo extraction mixture is separated
4h, obtaining must sunglo isolate.
(4) must sunglo isolate and water mixing carry out heating distillation extraction, wherein the solid-liquid ratio of isolate and water is
1g/L, distillation time 6h, obtaining must extractive of usnea.
It is understood that the preparation step of agastache extract, Fructus Kochiae extract and Radix Gentianae extract is mentioned with palpus sunglo
Take the preparation step of object identical, only plant material is different, and so it will not be repeated.
2~embodiment of embodiment 5 and comparative example
The preparation step of the anti-dandruff and itching-relieving composition of 2~embodiment of embodiment 5 and comparative example is identical with embodiment 1,
Only the percentage composition of each raw material is different, and the percentage composition of each raw material is shown in Table 1.
Each plant extracts in 2~embodiment of embodiment 5 and comparative example (must extractive of usnea, agastache extract, summer cypress
Seed extract and Radix Gentianae extract) preparation step with must extractive of usnea, the leaves of pulse plants with plant extracts corresponding in embodiment 1
Fragrant extract, Fructus Kochiae extract and Radix Gentianae extract) preparation step it is identical, only technological parameter in preparation step is different,
Technological parameter when prepared plant extracts is shown in Table 2.
Technological parameter in each embodiment of table 2 when prepared plant extracts
The measure of merit of anti-dandruff and itching-relieving composition and commercially available anti-dandruff and itching-relieving product that embodiment is prepared
1. anti-dandruff and itching-relieving is tested
Test method: volunteer 140 with severe dandruff symptom that the age is 40~50 years old are selected, wherein women
Volunteer is randomly divided into 7 groups by 52 people, 88 people of male, every group of 20 people, respectively using 1~embodiment of embodiment 5, comparative example
Anti-dandruff and itching-relieving composition and commercially available anti-dandruff and itching-relieving liquid.
Application method are as follows: after hair washing, be applied at scalp, 1 time a day, each 3ml~5ml is for 3 weeks.
Appraisal procedure: by the way of questionnaire survey, understand using after 3 weeks, subject changes product using rear anti-dandruff
The evaluation of kind situation.
Evaluation result is divided into: effect is unobvious, effect is general, more apparent, clearly.Significant effective rate=clearly
(example)/tested number (example) × 100%.
Test result is as shown in table 3:
3 anti-dandruff and itching-relieving test result of table
As shown in Table 3: in the volunteer using the anti-dandruff and itching-relieving composition of Examples 1 to 5, there is 50% respectively,
55%, 65%, 55%, 50% volunteer feels there is obviously anti-dandruff and itching-relieving effect, and using comparative example and commercially available goes
In the volunteer for considering antipruritic liquid to be worth doing, only 25% and 15% volunteer feels there is obviously anti-dandruff and itching-relieving effect respectively, this
Illustrate anti-dandruff and itching-relieving composition of the invention, anti-dandruff and itching-relieving effect is substantially better than comparative example and commercially available anti-dandruff and itching-relieving liquid.
2. safety evaluation
280 people of subject is selected, wherein male 130 people, 150 people of female, the age 20~40 years old, sensibility skin crowd.It will be by
Examination person is randomly divided into 7 groups, and every group of 40 people carry out spot examination experiment to every group of subject respectively.
Spot test method: selecting qualified spot tester, with enclosed patch test method, by tested material about 0.02ml~
0.025ml is applied in spot tester, and external application special adhesive tape is pasted on subject's forearm song side, removes tested material after 24 hours, in going
Except 30min after tested material spot tester, dermoreaction is observed after impression disappearance, by dermoreaction point in " cosmetics health specification "
Grade standard records its result.
Evaluation of result: reaction result is recorded by table 4 (skin adverse reaction grading standard), acquired results are as shown in table 5.
4 skin adverse reaction grading standard of table
5 safety evaluation result of table
Table 5 is as the result is shown: each all negative (scoring etc. of subjects skin in Examples 1 to 5 and comparative example
Grade: 0 grade).According to " cosmetics health specification " human skin class patch test judgment criteria, sample is bad anti-without skin to human body
It answers.And there are 51 order reactions in commercially available anti-dandruff and itching-relieving liquid.This shows that anti-dandruff and itching-relieving liquid of the invention shows higher peace
Quan Xing, even if using the crowd in sensitive skin, also without there is any abnormal response.
In summary known to anti-dandruff and itching-relieving test and security test: anti-dandruff and itching-relieving composition of the invention has anti-dandruff
Antipruritic effect and smaller to human body irritation.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of anti-dandruff and itching-relieving composition, which is characterized in that according to mass percentage meter, prepare the anti-dandruff and itching-relieving composition
Raw material include following component:
It must extractive of usnea 3%~30%, agastache extract 5%~20%, Fructus Kochiae extract 2%~20%, rough gentian extraction
Object 1%~25%, propylene glycol 30%~65% and deionized water 5%~30%.
2. anti-dandruff and itching-relieving composition according to claim 1, which is characterized in that the palpus extractive of usnea is must sunglo
Supercritical CO2Extract, the supercritical CO that the agastache extract is wrinkled giant hyssop2Extract, the Fructus Kochiae extract are the fruit of summer cypress
Supercritical CO2Extract, the supercritical CO that the Radix Gentianae extract is rough gentian2Extract.
3. anti-dandruff and itching-relieving composition according to claim 1, which is characterized in that according to mass percentage meter, prepare institute
The raw material for stating anti-dandruff and itching-relieving composition includes following component:
It must extractive of usnea 20%, agastache extract 10%, Fructus Kochiae extract 10%, Radix Gentianae extract 10%, propylene glycol
40% and deionized water surplus.
4. the preparation method of the described in any item anti-dandruff and itching-relieving compositions of claims 1 to 3, which is characterized in that including walking as follows
It is rapid:
By the deionized water and mixed with propylene glycol and 75 DEG C~85 DEG C are heated to, stirring 25min~35min；
The palpus extractive of usnea, agastache extract, Fructus Kochiae extract and Radix Gentianae extract is added, stirs molten to each component
Solution, obtains anti-dandruff and itching-relieving composition.
5. the preparation method of anti-dandruff and itching-relieving composition according to claim 4, which is characterized in that further include the palpus sunglo
The preparation step of extract, the preparation step of the agastache extract, the preparation step of the Fructus Kochiae extract and the dragon
The preparation step of gall extract:
It is described must extractive of usnea preparation step are as follows: must sunglo crush, sieving, obtain palpus sunglo powder；Use supercritical CO2
Fluid extracts the palpus sunglo powder, and obtaining must sunglo extraction mixture；The palpus sunglo extraction mixture is carried out
Separation, obtaining must sunglo isolate；The palpus sunglo isolate and water are mixed and carry out heating distillation extraction, obtains palpus after condensation
Extractive of usnea；
The preparation step of the agastache extract are as follows: wrinkled giant hyssop is crushed, sieving, obtain Wrinkled Gianthyssop Herb；Use supercritical CO2Fluid pair
The Wrinkled Gianthyssop Herb is extracted, and wrinkled giant hyssop extraction mixture is obtained；Wrinkled giant hyssop extraction mixture is separated, wrinkled giant hyssop is obtained
Isolate；The wrinkled giant hyssop isolate and water are mixed and carry out heating distillation extraction, obtains agastache extract after condensation；
The preparation step of the Fructus Kochiae extract are as follows:
The fruit of summer cypress is crushed, sieving, obtains Belvedere Fruit；Use supercritical CO2Fluid extracts the Belvedere Fruit,
Obtain fruit of summer cypress extraction mixture；Fruit of summer cypress extraction mixture is separated, fruit of summer cypress root isolate is obtained；It will be described
Fruit of summer cypress isolate and water mixing carry out heating distillation extraction, obtain Fructus Kochiae extract after condensation；And
The preparation step of the Radix Gentianae extract are as follows: rough gentian is crushed, sieving, obtain rough gentian powder；Use supercritical CO2Fluid pair
The rough gentian powder is extracted, and rough gentian extraction mixture is obtained；Rough gentian extraction mixture is separated, rough gentian is obtained
Isolate；The rough gentian isolate and water are mixed and carry out heating distillation extraction, obtains Radix Gentianae extract.
6. the preparation method of anti-dandruff and itching-relieving composition according to claim 5, which is characterized in that in the step of the sieving
The aperture of sieve is greater than or equal to 300 mesh.
7. the preparation method of anti-dandruff and itching-relieving composition according to claim 5, which is characterized in that described to use supercritical CO2
CO in the step of extraction2Flow velocity is 1.5kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is 35 DEG C, extraction
Taking the time is 5h.
8. the preparation method of anti-dandruff and itching-relieving composition according to claim 5, which is characterized in that in the step of the separation
Separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
9. the preparation method of Anti-hair loss composition according to claim 5, which is characterized in that the step of the distillation extraction
In, the solid-liquid ratio of the isolate and the water is 1g/L~5g/L, and distillation time is 6h~8h.
10. the described in any item anti-dandruff and itching-relieving compositions of Claims 1 to 4 or claim 5~9 it is described in any item it is anti-dandruff only
The anti-dandruff and itching-relieving composition that is prepared of preparation method of composition of itching is preparing the application in hair washing product or hair products.
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