CN100490874C - Chinese medicine composition for treating diabetes and method for preparing the same - Google Patents
Chinese medicine composition for treating diabetes and method for preparing the same Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for curing diabetes mellitus. The main compositions by weight portion of the composition are: 15 to 28 portions of aconite, 10 to 18 portions of seed of nuxvomica poison nut, 10 to 20 portions of Aconitum pendulum Busch, 15 to 30 portions of rhizoma coptidis, 35 to 45 portions of ophiopogon root and 15 to 30 portions of liquorice. The method for making the traditional Chinese medicine is as follows: the medicines are washed off; the aconite, the Aconitum pendulum Busch and the seed of nuxvomica poison nut are detoxificated and are grinded into medicine powder which is mixed and is extracted by ethanol to obtain the active extractive; other drug ingredients are decocted twice, the filter liquor of two times is mixed to obtain the extractive, the active extractive obtained in the prior step is added, the mixture is stirred evenly and is condensed into paste, the mixture is dried and grinded into the fine powder with 200 to 400 meshes so that the powder preparation is obtained. The traditional Chinese medicine composition has the evident functions of mediating the nervus centralis, getting through the channels and collaterals, inhibiting virus, facilitating the nerve cell restoration and islet cell restoration, reducing the blood sugar, reducing the complicating diseases, and increasing the ability of the nervus centralis to regulate the nerve of the digestive system, fulfills the purpose of addressing both the symptoms and root causes, and has evident effect and short treatment cycle and low recurrence rate.
Description
Technical field:
The present invention relates to a kind of Chinese medicine and preparation method thereof, specifically refer to a kind of treatment diabetes Chinese medicine composition and preparation method thereof.
Background technology:
Diabetes are commonly considered as polygenic inheritance and environmental factors causes defect of insulin secretion, cause the incretion metabolism disease of multisystem, MOFE at last, factors such as in the modern life, people's stress is big, physical training is few, eating and drinking too much at one meal, obesity, subhealth state, heredity.Just very easily blood glucose taking place and increase, causes the generation of diabetes when immunologic hypofunction.China's diabetes number of patients occupies sizable ratio, and continues to have the trend of increase.The invention of insulin and extensive use have obviously solved the misery of most patient, but still are to mend the day after tomorrow, rely on all the life, cure the symptoms, not the disease, and will cause the generation of multiple complications.No matter be modern simple blood sugar lowering, it is low anti-that glucose in urine solves insulin, insulin receptor defect, increase insulin and cell quantity, the treatment " three-many-one-little " of quenching one's thirst of the tradition traditional Chinese medical science, sweet sour yin nourishing, harmonizing the spleen and stomach, the all many-sides of the kidney invigorating nourishing the liver obtain important breakthrough, and receive certain effect, but most Therapeutic Method are also just dealt with problems from single aspect and presentation, people's body running is the balanced body of a complexity, need newest fruits and multidisciplinary field in conjunction with modern medicine, employing interdisciplinary science theory, utilization Chinese medical discrimination thought integral body is standardized, equilibrium between yin and yang reaches the treating both the principal and secondary aspects of a disease purpose.
The risk factor of diabetes is a lot, the basic reason that causes diabetes is that the disease of metabolic system is " ying-qi " deficiency, " ying-qi " is the gas of nutrition, main essence of water and grain material instituteization life by transporting and transforming function of the spleen and stomach, " ying-qi " is distributed among the blood vessels, meet the tendency the whole body, change hemopoietic liquid, bring into play its nutrition and act on all over the body.Here " gas " can be understood as the nervus centralis command system of modern medicine, when the operation various water paddy thing through peptic digestion, transform in the absorption process in nutrition, spleen " system blood ", " main fortuneization ", under the normal condition, metabolic system can be converted into the nutrition whole body such as albumen, fat, plurality of enzymes automatically according to the equilibrium between yin and yang principle by the insulin blood sugar regulation of beta Cell of islet generation and according to individual need; Human five internal organs's six internal organs are easily by virus or bacterial infection, encroached on, immune function of human body and physical strength have determined virus or antibacterial to the invasion and attack degree of metabolic system and the pathological change form of internal organs, islet function is easy to be encroached on when immunologic function degression, cause beta Cell of islet dysfunction or damage, cause beta Cell of islet not worked or few work.When the metabolism system needs insulin secretion, the under-supply or not supply of insulin will take place, cause blood glucose, glucose in urine to increase, cause the generation of diabetes.
Press the Chinese medical discrimination theory, the diabetes main diseases is " ying-qi " deficiency because of mechanism, invades in the warm epidemic disease poison, and the hear rate stagnation of QI, QI and blood are not all right, the dryness of the stomach spleen weak, due to the internal organs yin and yang imbalance.Treatment should be with immunomodulating, equilibrium between yin and yang, strengthening the body resistance, eliminating evilly take stopgap measures, purpose that dredging the meridian, activating blood circulation to dissipate blood stasis reach treating both the principal and secondary aspects of a disease.
Summary of the invention:
The object of the present invention is to provide a kind for the treatment of both the principal and the secondary aspects of a disease at the same time, effect is obvious, the treatment diabetes Chinese medicine composition that treatment cycle is short and relapse rate is low.Another object of the present invention is to provide a kind of preparation method for the treatment of the diabetes Chinese medicine composition.
The present invention seeks to realize like this, this treatment diabetes Chinese medicine composition, its primary raw material medicine and weight proportion are as follows: 15-28 parts of Radix Aconiti Lateralis Preparatas, 10-18 parts of Semen Strychni, 10-20 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 15-30 parts of Rhizoma Coptidis, 35-45 parts of Radix Ophiopogonis, 15-30 parts in Radix Glycyrrhizae.
Optimum weight proportioning of the present invention is as follows: 28 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Semen Strychni, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 20, part, 30 parts of Rhizoma Coptidis, 45 parts of Radix Ophiopogonis, 30 parts in Radix Glycyrrhizae.
The present invention also comprises one of following crude drug or its combination: 10-18 parts of Hirudos, 30-45 parts in the Radix Rehmanniae, 30-45 parts of Rhizoma Atractylodis, 8-15 parts of Rhizoma Zingiberiss.
In the side with Radix Aconiti Lateralis Preparata, Semen Strychni, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), be the monarch drug group, the hot big heat of Radix Aconiti Lateralis Preparata is poisonous, goes into 12 warps.Effect with antiinflammatory calmness, blood vessel dilating, activating blood circulation to dissipate blood stasis.Aconite alkaloid can suppress excited conduction in nerve trunk in the Radix Aconiti Lateralis Preparata, promotes the adrenal cortex effect, and promotes the increase of hepatic glycogen; also have defying age to improve immunity function, the Radix Aconiti property of medicine and Radix Aconiti Lateralis Preparata are close, and Radix Aconiti Lateralis Preparata can substitute with Radix Aconiti; consumption is identical with Radix Aconiti Lateralis Preparata, also in protection domain of the present invention.The Semen Strychni bitter cold is poisonous, goes into the liver spleen channel, and stronger antiinflammatory, digestion promoting function are arranged, and has stimulating central nervous system and promotes sanguimotor function.Strychnine can microcirculation improvement and promotion hemopoietic function.Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is gone into cardiopulmonary liver three warps, and activating blood circulation to dissipate blood stasis has the obvious anti-inflammatory and anti effect.But Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is very toxic, and therapeutic dose and toxic dose are more approaching, needs science to concoct and the control consumption.
Above Radix Aconiti Lateralis Preparata, Semen Strychni, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) are monarch's group, set upright solid wood, reconcile ying-qi, dredging the meridian, raise immunity, repair impaired islet function, thereby reach blood sugar lowering, glucose in urine purpose.
With the Radix Rehmanniae, Rhizoma Atractylodis, Radix Ophiopogonis be the minister group, eliminating pathogenic factor for supporting vital QI, activating blood circulation to dissipate blood stasis, strengthening spleen, tonifying kidney, to give birth to Qinghua turbid.The Radix Rehmanniae has the hormonal regulation effect, can adjust carbohydrate metabolism disturbance.Rhizoma Atractylodis can promote gastrointestinal motility, strengthen insulin secretion.Radix Ophiopogonis polysaccharide can increase islet cells quantity and promote islet cell function to recover.The Radix Rehmanniae in the ministerial drug group, Rhizoma Atractylodis, Radix Ophiopogonis the blood sugar lowering effect arranged all, dispel, radically reform with exopathogen.
Assistant is with Hirudo, Rhizoma Coptidis, eliminating evilly stimulates the menstrual flow, activating blood circulation to dissipate blood stasis, heat-clearing and toxic substances removing.Hirudo contains a large amount of aminoacid and various trace elements, and Hirudo have antithrombotic, expansion blood capillary, improves blood flow, blood circulation promoting, the effect of enhancing cell activation; The Rhizoma Coptidis anti-bacteria and anti-virus is gone into the heart, liver, gallbladder, spleen, stomach, large intestine channel, heat clearing and damp drying.
With Radix Glycyrrhizae, Rhizoma Zingiberis is the messenger drug group, all medicines of balance, and the toxicity of separating all medicines is alleviated the property of medicine again, and is whole standardized, improves curative effect.Rhizoma Zingiberis goes into lung taste warp, the cold expelling that induces sweat, and " it is not hot that Rhizoma Zingiberis does not have Radix Aconiti Lateralis Preparata " strengthens the effect of Radix Aconiti Lateralis Preparata cold relieving, with thermal detoxification, activating cell.And Radix Aconiti Lateralis Preparata gets Rhizoma Zingiberis minimizing toxicity.The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing is in harmonious proportion hundred medicines, and separates the poison of hundred medicines.
Monarch of the present invention, minister, help, make and respectively execute its effect, each is mended, and it is short, interacts, have tangible conciliation nervus centralis, get through meridians, suppress virus, enhance immunity ability and improve digestive system function promotes neurocyte, islet cells reparation and blood sugar lowering effect.Strengthen the regulatory function of nervus centralis to the digestive system nerve.Suppress virus and inflammation, blood sugar lowering, glucose in urine reduce the generation of complication, reach the purpose for the treatment of both the principal and secondary aspects of a disease, and effect is obvious, and treatment cycle is short and relapse rate is low.
The preparation method of above-mentioned treatment diabetes Chinese medicine composition, comprise the steps: that 1. wash medical material earlier, wherein Radix Aconiti Lateralis Preparata is made RADIX ACONITI LATERALIS PREPARATA, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) Radix Glycyrrhizae system, Semen Strychni stir-baking with sand or fried, Hirudo are scalded the drum detoxification with Pulvis Talci and handle, then with Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis natural drying or oven dry, pulverizing is 200-400 order medicated powder, mixing all medicated powder, is 75% ethanol extraction 1-3 times with concentration, and extraction time is 24 hours, filter, filtrate merges, and is concentrated, dry, gets activity extract; 2. other medical material is put into extractor, soaks 30 minutes～60 minutes, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get extract, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Hirudo, the Rhizoma Coptidis activity extract of step stir before adding, and it is 1.30-1.35 thick paste shape that filtrate is condensed into density, dries, is ground into 200-400 order fine powders, gets powder.
Or, add appropriate amount of auxiliary materials with above-mentioned all medicine deduction ointment, make capsule, tablet, granule, drop pill or powder with common process.Adjuvant is meant filler, lubricant, and filler comprises one or more in solvable or microsolubility calcium salt, mannitol, starch, dextrin, the microcrystalline Cellulose; Lubricant comprises one or more in micropowder silica gel, Pulvis Talci, the magnesium stearate.
Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis natural drying or oven dry, pulverizing are 200-400 order medicated powder, are that 75% ethanol extraction gets activity extract with mixed powder concentration, and all property of medicine is interacted, and improve effect.
Preparation clinical test results of the present invention is as follows:
The present invention observes through 212 examples through clinical practice for many years, and this 212 routine case is divided into 2 groups at random, and wherein 112 examples are treated with the capsule of treatment diabetes of the present invention, and 100 is routine with the treatment of glipizide western drug.Reach blood glucose of beginning per 1～2 weekly check in back, glucose in urine before the treatment to observe its variation, require the patient must adhere to taking medicine one more than the course of treatment, three months is a course of treatment, continue to keep diet and physical exertion constant during the treatment, forbid adding other hypoglycemic in, western drug, viewing duration requires suitably to keep on a diet, and takes this prescription continuously after two courses of treatment, and total effective rate reaches 92.5 ℅.
Treatment diabetes capsule group of the present invention (112 people), each oral 3～4, every day 3 times, three months is a course of treatment, drug withdrawal is obeyed the next course of treatment after 3 days again.
Glipizide treatment group (100 people): each oral 5mg, every day 2～3 times.
2 group of 212 routine case treated Comparison of therapeutic such as following table:
| Nomenclature of drug | Produce effects | Effectively | Invalid | Effective percentage % | Inefficiency % |
| The present invention treats the diabetes capsule | 40 | 64 | 8 | 92.5 | 7.5 |
| The glipizide tablet | 30 | 50 | 20 | 80 | 20 |
The specific embodiment:
Embodiment 1: get 28 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Semen Strychni, 20 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 30 parts of Rhizoma Coptidis, 45 parts of Radix Ophiopogonis, 30 parts in Radix Glycyrrhizae.Earlier medical material is washed Radix Aconiti Lateralis Preparata wherein, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), the Semen Strychni detoxification is handled, then with Radix Aconiti Lateralis Preparata, and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis four Chinese medicine material natural drying or oven dry, pulverizing is 200-400 order medicated powder, mixes all medicated powder, with concentration is 75% ethanol extraction 1-3 times, extraction time is 24 hours, filters, and filtrate merges, concentrated, dry, get activity extract; Other medical material is put into extractor, soaks 30 minutes～60 minutes, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get extract, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, the Rhizoma Coptidis activity extract of step stir before adding, and it is 1.30-1.35 thick paste shape that filtrate is condensed into density, dries, is ground into 200-400 order fine powders, gets powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process.Usage is every day 3 times, and each 800 milligrams, ante cibum or one hour after meal take.
Embodiment 2: get 20 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Semen Strychni, 15 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 18 parts of Rhizoma Coptidis, 40 parts of Radix Ophiopogonis, 20 parts in Radix Glycyrrhizae, 15 parts of Hirudos.Radix Aconiti Lateralis Preparata wherein, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Hirudo detoxification are handled, then with Radix Aconiti Lateralis Preparata, and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis four Chinese medicine material natural drying or oven dry, pulverizing is 200-400 order medicated powder, mixes all medicated powder, is 75% ethanol extraction 1-3 times with concentration, extraction time is 24 hours, gets activity extract; Other medical material is put into extractor, soaks 30 minutes～60 minutes, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach, twice filtrate is merged, get extract, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Radix Aconiti Lateralis Preparata, the Rhizoma Coptidis activity extract of step stir before adding, filtrate is condensed into the thick paste shape, is ground into 200-400 order fine powders, gets powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process, usage is every day 3 times, and each 800 milligrams, ante cibum or one hour after meal take, and plain boiled water is taken after mixing it with water.
Embodiment 3: get 20 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Semen Strychni, 15 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 18 parts of Rhizoma Coptidis, 40 parts of Radix Ophiopogonis, 20 parts in Radix Glycyrrhizae, 15 parts of Hirudos, 35 parts in the Radix Rehmanniae, 35 parts of Rhizoma Atractylodis, 12 parts of Rhizoma Zingiberiss.Radix Aconiti Lateralis Preparata wherein, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Hirudo detoxification are handled, then with Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis four Chinese medicine material natural drying or oven dry, pulverizing is 200-400 order medicated powder, mixes all medicated powder, with concentration is 75% ethanol extraction 1-3 times, extraction time is 24 hours, and filtrate merges, and gets activity extract; Other medical material is put into extractor, soaks 30 minutes～60 minutes, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, twice filtrate is merged, get extract, Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, the Rhizoma Coptidis activity extract of step stir before adding, and filtrate is condensed into the thick paste shape, be ground into 200-400 order fine powders, get powder.Powder is added right amount of auxiliary materials, make capsule, tablet with common process, usage is every day 3 times, and each 800 milligrams, ante cibum or one hour after meal take, and plain boiled water is taken after mixing it with water.
Concrete case
1, the patient man suffered from diabetes 10 years in 53 years old.Fasting glucose 15.6mmol/l whenever takes blood sugar lowering before the meal, through how tame hospital, and several different methods treatment, DeGrain.Lose weight, health is become thin.Obey diabetes preparation capsule of the present invention after two months, fasting glucose returns to 5.8mmol/l, 2.5 kilograms of weight increase.So far remain stable any medicine of no longer obeying in August, 2005.And recovered the sexual function that more than ten years do not have.
2, thirsty polydipsia appearred in patient man readme in 46 years old before 2 years, fatigue and weak, and frequent micturition frequent micturition, body are gradually thin, fasting glucose 7.3mmol/l.After taking medicine 1 month, diversion reduces, and urine is reduced, and fasting glucose remains on about 6mmol/l.
Claims (6)
1. treat the diabetes Chinese medicine composition for one kind, it is characterized in that: its primary raw material medicine and weight proportion are as follows: 15～28 parts of Radix Aconiti Lateralis Preparatas, 10～18 parts of Semen Strychni, 10～20 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 15～30 parts of Rhizoma Coptidis, 35～45 parts of Radix Ophiopogonis, 15～30 parts in Radix Glycyrrhizae.
2. treatment diabetes Chinese medicine composition according to claim 1, it is characterized in that: its crude drug and weight ratio are as follows: 28 parts of Radix Aconiti Lateralis Preparatas, 15 parts of Semen Strychni, 20 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 30 parts of Rhizoma Coptidis, 45 parts of Radix Ophiopogonis, 30 parts in Radix Glycyrrhizae.
3. treatment diabetes Chinese medicine composition according to claim 1 is characterized in that: also comprise one of following crude drug or its combination: 10～18 parts of Hirudos, 30～45 parts in the Radix Rehmanniae, 30～45 parts of Rhizoma Atractylodis, 8～15 parts of Rhizoma Zingiberiss.
4. according to claim 1 or 3 described treatment diabetes Chinese medicine compositions, it is characterized in that: it is capsule, tablet, granule, drop pill or powder.
5. preparation method as diabetes Chinese medicine composition as described in the claim 3, it is characterized in that: comprise the steps: that 1. wash medical material earlier, wherein Radix Aconiti Lateralis Preparata is made RADIX ACONITI LATERALIS PREPARATA, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) Radix Glycyrrhizae system, Semen Strychni stir-baking with sand or fried detoxification are handled, Hirudo is scalded the processing of drum detoxification with Pulvis Talci, then with Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, Rhizoma Coptidis natural drying or oven dry, pulverizing is 200-400 order medicated powder, is 75% ethanol extraction 1-3 times with concentration, and extraction time is 24 hours, filter, filtrate merges, and is concentrated, dry, gets activity extract; Other medical material is put into extractor, soaks 30 minutes～60 minutes, decocts 2.5 hours～3 hours for the first time, leaches; Decocted 1.5 hours～2 hours for the second time, leach; Twice filtrate is merged, get extract; 2. Radix Aconiti Lateralis Preparata, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Semen Strychni, the Rhizoma Coptidis activity extract of step stir before adding, and it is 1.30-1.35 thick paste shape that filtrate is condensed into density, dries, is ground into 200-400 order fine powders, get powder.
6. the preparation method of treatment diabetes Chinese medicine preparation according to claim 5 is characterized in that also comprising the steps: powder is added right amount of auxiliary materials, makes capsule, tablet, granule, drop pill or powder with common process.
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| 糖尿病的中药疗法研究进展. 李志豪.杭州师范学院学报(医学版)，第27卷第1期. 2007 * |
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