CN108567638A - A kind of potent moisture-preserving dressing with epidermis repair function - Google Patents
A kind of potent moisture-preserving dressing with epidermis repair function Download PDFInfo
- Publication number
- CN108567638A CN108567638A CN201810648442.5A CN201810648442A CN108567638A CN 108567638 A CN108567638 A CN 108567638A CN 201810648442 A CN201810648442 A CN 201810648442A CN 108567638 A CN108567638 A CN 108567638A
- Authority
- CN
- China
- Prior art keywords
- skin
- sodium
- moisture
- repair function
- preserving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8188—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bonds, and at least one being terminated by a bond to sulfur or by a hertocyclic ring containing sulfur; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of potent moisture-preserving dressings with epidermis repair function, including constituent content weight percent it is as follows：Polymer hyaluronic acid sodium 0.03% 2%, kayexalate 0.03% 8%, xanthans 0.03% 2%, Sodium Polyacrylate 0.02% 2%, carbomer 0.05% 3%, the transparent sour sodium of low molecule 0.03% 2%, amino acid humectant 0.2% 6%, hydrolyze glycosaminoglycan 0.01% 5%, reed fragrant plant oil 0.3% 6%, glycerine 1% 10%, propylene glycol 0.5% 10%, butanediol 0.5% 12%, Gotu Kola P.E 0.1% 8%, allantoin 0.01% 3%, preservative 0.01% 0.4%, pH adjusting agent 0.01% 1%, water surplus.The effect that product of the present invention has supplement moisture of skin, locks moisture of skin, repairs skin barrier.Suitable for being repaired after inflammation skin, allergic skin, skin trauma and laser operation, skin injury is fundamentally solved the problems, such as, and control difficulty in relapse after healing.
Description
Technical field
The invention belongs to skin care applications, it is related to a kind of moisture-preserving dressing, it is especially a kind of with epidermis repair function
Potent moisture-preserving dressing.
Background technology
Under normal circumstances, the skin of human body contains a large amount of moisture, and moisture is very heavy for keratoderma update
It wants.Lack moisture, the update of cuticula can be caused to be difficult to be normally carried out.Cuticula moisture is reduced, and can lead to cuticula update speed
It spends slack-off, so that numerous corneocytes not fallen off remain in always skin surface, finally causes the desquamation of skin and tortoise
It splits.Moisture is also to maintain the important substance that natural moisturizing factor plays a role in skin keratinocytes, therefore, once moisture is not
Foot, it is possible to cause the barrier function of skin to be damaged, environmental stimuli object is also easier to enter skin, finally causes various
Skin disease, for example skin allergy, itch and redness etc..It stretches tight in addition, the skin of water shortage not only will appear to do, is tight puckery, or even can draw
The problems such as obfuscation is heavy, pore is coarse and microgroove, aging.Therefore, replenishing water and preserving moisture is all for skin nursing all the time
It is vital.
Replenishing water and preserving moisture product currently on the market, most of water supplement function for only focusing on product, be added to many moisturizings at
Point, skin is the ability with absorption moisture, but if skin barrier is impaired, the moisture in epidermis can pass through the side of evaporation
Formula is diffused into air and is lost in reduction.Such replenishing water and preserving moisture product is unable to reach long-acting moisturizing, and it is even more impossible to fundamentally solve
Certainly problem skin and reconstruction healthy skin.
Currently, liquid dressing class product plays the work of protection damaged skin or wound mostly with physics mulching wound in the market
With not having functionality substantially, healthy skin can not be rebuild.In addition, some skin-protection products are toward being added antimicrobial in liquid dressing
Agent etc., to have the function that anti-inflammatory, anti-infective and accelerate to heal, but these are all to be compounded with drug ingedient inside, to human body
With certain side effect and harm.
In the prior art mostly for the purpose of moisturizing, never considers how to lock moisture, allow the permanent moisturizing of skin, such as
CN106265192A and CN02370606A.There are also latching moisture is considered how, as CN104622765A keeps skin permanent
Replenishing water and preserving moisture, but since its water lock structure is too simple, water lock effect is limited.In addition, documents CN104622765A is one
The facial mask of kind replenishing water and preserving moisture is used not as good as liquid dressing conveniently, and covering skin area is also limited.
In view of the deficiencies of the prior art, the present invention is absorbed from water conservation deep layer, water lock, natural plant composition antibacterial anti-inflammatory three
Aspect is started with simultaneously, is given skin replenishing water and preserving moisture, fundamentally damaged skin is made to get well.The present invention is to pass through high molecular material
Three-dimensional netted supporting structure water lock film is built, the liquid dressing in conjunction with prepared by moisturizing ingredient, plant extracts.By without any
The mode of side effect promotes skin wound healing.It is coatable on illing skin when use, or pass through carrier (such as non-woven fabrics) and inhale
Attached liquid dressing, spreads on illing skin.While to skin skin moisturizing, skin barrier is repaired, reaches supplement skin water
Divide, locks moisture of skin for a long time, repairs three big effect of skin barrier.Can rebuild healthy skin, enhancing skin to environmental stimuli because
The resistivity of son.It fundamentally solves the problems, such as skin injury, and controls difficulty in relapse after healing.
Invention content
To achieve the purpose that supplement moisture of skin simultaneously, lockking moisture of skin, reparation skin barrier for a long time, the present invention provides
A kind of potent moisture-preserving dressing with epidermis repair function, is achieved through the following technical solutions.
A kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent it is as follows：
Polymer hyaluronic acid sodium 0.03%-2%, kayexalate 0.03%-8%, xanthans 0.03%-2%,
Sodium Polyacrylate 0.02%-2%, carbomer 0.05%-3%, the transparent sour sodium 0.03%-2% of low molecule, amino acid humectant
0.2%-6% hydrolyzes glycosaminoglycan 0.01%-5%, reed fragrant plant oil 0.3%-6%, glycerine 1%-10%, propylene glycol
0.5%-10%, butanediol 0.5%-12%, Gotu Kola P.E 0.1%-8%, allantoin 0.01%-3%, preservative
0.01%-0.4%, pH adjusting agent 0.01%-1%, water surplus；The polymer hyaluronic acid sodium molecule amount is 600,000-150 ten thousand
Between, the transparent sour sodium molecule amount of the low molecule is between 8000-10 ten thousand.
Preferably, a kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent
It is as follows：Polymer hyaluronic acid sodium 0.05%-1%, kayexalate 0.04%-6%, xanthans 0.05%-1% gather
Sodium acrylate 0.04%-1%, carbomer 0.1%-2%, the transparent sour sodium 0.05%-1% of low molecule, amino acid humectant
0.4%-5% hydrolyzes glycosaminoglycan 0.01%-4%, reed fragrant plant oil 0.5%-4%, glycerine 1%-8%, propylene glycol 1%-
8%, butanediol 1%-10%, Gotu Kola P.E 0.1%-6%, allantoin 0.01%-2%, preservative 0.01%-0.4%,
PH adjusting agent 0.01%-1%, water surplus.
Preferably, a kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent
It is as follows：Polymer hyaluronic acid sodium 0.05%-0.5%, kayexalate 0.05%-5%, xanthans 0.05%-
0.5%, Sodium Polyacrylate 0.05%-0.5%, carbomer 0.1%-1%, the transparent sour sodium 0.05%-0.5% of low molecule, ammonia
Base acid moisturizer 0.5%-3% hydrolyzes glycosaminoglycan 0.01%-2%, reed fragrant plant oil 0.5%-3%, glycerine 1%-5%, third
Glycol 1%-5%, butanediol 1%-8%, Gotu Kola P.E 0.1%-5%, allantoin 0.01%-1%, preservative
0.01%-0.4%, pH adjusting agent 0.01%-1%, water surplus.
Preferably, a kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent
It is as follows：Polymer hyaluronic acid sodium 0.4%, kayexalate 4%, xanthans 0.4%, Sodium Polyacrylate 0.3%, card wave
Nurse 0.8%, the transparent sour sodium 0.4% of low molecule, amino acid humectant 2% hydrolyze glycosaminoglycan 1.5%, reed fragrant plant oil
2%, glycerine 4%, propylene glycol 4%, butanediol 6%, Gotu Kola P.E 3%, allantoin 0.8%, preservative 0.1%, pH tune
Save agent 0.2%, water surplus.
Preferably, the pH adjusting agent is triethanolamine.
The present invention formulation Design Principle be mainly：By water lock system, water conservation deep layer absorption system, skin barrier dummy
System's composition.By dihydric alcohol open keratoderma, promote water conservation deep layer absorption system and skin barrier repair system to water
The absorption divided, moisturizes to skin.By water lock system, water lock film is formed, builds physical skin barrier, and moisture lock is existed
In skin.To have the function that long-acting replenishing water and preserving moisture and repair cell barrier.
The water lock system is mainly by polymer hyaluronic acid sodium, kayexalate, carbomer, xanthans, poly- third
Olefin(e) acid sodium forms.Polymer hyaluronic acid sodium, carbomer, xanthans are positioned in water and are swollen, and pH value is adjusted using triethanolamine
It interacts between 8.5-10, then with kayexalate, polymer hyaluronic acid sodium passes through with kayexalate
Bridging and molecular folding act on forming level-one holder.Under alkaline condition, the carbomer molecule of curling is because of electric repulsion opening, level-one
Holder enters in carbomer long-chain molecule gap, forms three-dimensional netted supporting structure.When pH value being recalled to 5.0-8.0 again,
Carbomer molecular tension reduces, and can form stable three-dimensional netted supporting structure, as shown in Figure 1.It is added and protects in preparation process
Depth of water layer absorption reagent is similarly locked in three-dimensional netted supporting structure.When smearing or spreading on skin or wound, formed
Has the water lock film layer of functional three-dimensional netted holder.Prevent external factor (anaphylactogen, bacterium, dust etc.) to skin
Stimulation, and lock moisture of skin, prevent moisture of skin from volatilizing.Reach permanent moistening effect, moreover it is possible to promote epidermal cell to divide,
Repair skin barrier.The present invention adjusts the variation of carbomer molecular structure by changing pH, to be bumped into polymer hyaluronic acid
The high molecular materials such as sodium, kayexalate, Sodium Polyacrylate composition build the water lock film system of three-dimensional net structure.Appoint
What causes the variation of carbomer molecular structure by way of changing pH value, be bumped into other high molecular materials formed it is three-dimensional netted
The technology of supporting structure, belongs to and falls within the scope of the present invention.
The water conservation deep layer absorption system mainly by the transparent sour sodium of low molecule, amino acid humectant, reed fragrant plant oil, glycerine,
Propylene glycol, butanediol, hydrolysis glycosaminoglycan composition, wherein amino acid humectant, reed fragrant plant oil, glycerine, propylene glycol, fourth two
Alcohol, hydrolysis glycosaminoglycan have water retention.In addition, glycerine, propylene glycol, butanediol can softening skin cuticula, promote
Absorption of the skin to moisture.The transparent sour sodium of hydrolysis glycosaminoglycan collaboration low molecule can further promote moisture to penetrate skin
Into skin corium, it is the formation of 100,000-60 ten thousand intermediate molecular weight hyaluronic acid to promote own cells middle-molecular-weihydroxyethyl.
The Gotu Kola P.E, allantoin are nontoxic non-stimulated and have anti-inflammatory, antibacterial effect, skin wound can be accelerated to be cured
It closes.Skin barrier is constituted together in conjunction with water lock film system, water conservation deep layer absorption system and repairs system, and in water lock film system
Three-dimensional netted supporting structure contributes to Skin Cell (can as can be seen from Figure 1, wherein 1 indicates that cell is (white along stent migration, growth
Color bright spot part is cell, rounded, oval or irregular similar round)), be conducive to epidermis reparation.
The present invention also provides a kind of preparation methods of the potent moisture-preserving dressing with epidermis repair function comprising following
Step：
(1) each component is weighed by formula ratio, by polymer hyaluronic acid sodium, carbomer, the transparent sour sodium of low molecule, allantois
Element, xanthans, Sodium Polyacrylate, glycerine, propylene glycol, butanediol are added to the water, and pH value is adjusted to 8.5-10 with pH adjusting agent
Between, kayexalate, stirring and dissolving are added, warming while stirring reacts 0.5-2 hour to 80-95 degrees Celsius,
It is subsequently cooled to 15-45 degrees Celsius, obtained mixture A is spare；
(2) by Gotu Kola P.E, amino acid humectant, reed fragrant plant is oily, and hydrolysis glycosaminoglycan is added to mixture A
In, pH value is adjusted between 4.0-8.0 with pH adjusting agent, and preservative is added, stirs 0.5-1.5 hour (preferably 0.8-1.2
Hour) liquid dressing is made；
(3) dressing is sub-packed in container according to product specification (in bottle or hose), the dressing is made.
Preferably, in the step of preparation method of a kind of potent moisture-preserving dressing with epidermis repair function (1)
PH value is 9.0-9.5.
Preferably, in the step of preparation method of a kind of potent moisture-preserving dressing with epidermis repair function (1)
Warming while stirring is to 82-87 degrees Celsius.
Preferably, in the step of preparation method of a kind of potent moisture-preserving dressing with epidermis repair function (1)
Reaction time is 0.8-1.5 hours.
Compared with prior art, beneficial effects of the present invention：By polymer hyaluronic acid sodium, carbomer, xanthans, gather
The high molecular materials such as sodium styrene sulfonate and special process build the water lock film of three-dimensional netted supporting structure.By three-dimensional netted
Supporting structure delivery moisturizing ingredient, skin repair ingredient and deep skin moisturizing system can accelerate skin cell proliferation to divide,
Accelerate to repair damaged skin.The work(that supplement moisture of skin can be reached simultaneously, moisture of skin is lockked for a long time, repair skin barrier
Effect.The cold compress nursing for treating that can be used for repairing after all kinds of inflammation skins, allergic skin, skin trauma, burn, laser operation.
Description of the drawings
Fig. 1 is the three-dimensional netted supporting structure electron microscope inside dressing made from the embodiment of the present invention 2.
Specific implementation mode
It is illustrated with reference to embodiment is further to the present invention.These embodiments are to make those skilled in the art
Technical scheme of the present invention is become apparent from, rather than limiting the invention.
Embodiment 1
A kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent it is as follows：
Polymer hyaluronic acid sodium 0.03%, kayexalate 0.03%, xanthans 0.03%, Sodium Polyacrylate
0.02%, carbomer 0.05%, the transparent sour sodium 0.03% of low molecule, amino acid humectant 0.2%, hydrolysis glycosaminoglycan
0.01%, reed fragrant plant oil 0.3%, glycerine 1%, propylene glycol 0.5%, butanediol 0.5%, Gotu Kola P.E 0.1%, allantoin
0.01%, preservative 0.01%, pH adjusting agent 0.01%, water surplus.
A kind of preparation method of the potent moisture-preserving dressing with epidermis repair function comprising following steps：
(1) each component is weighed by formula ratio, by polymer hyaluronic acid sodium, carbomer, the transparent sour sodium of low molecule, allantois
Element, xanthans, Sodium Polyacrylate, glycerine, propylene glycol, butanediol are added to the water, and pH value is adjusted to 8.5-9.0 with pH adjusting agent
Between, kayexalate is added, stirring and dissolving, warming while stirring is to 80 degrees Celsius, then reacts 0.5 hour, so
Postcooling is to 15 degrees Celsius, and obtained mixture A is spare；
(2) by Gotu Kola P.E, amino acid humectant, reed fragrant plant is oily, and hydrolysis glycosaminoglycan is added to mixture A
In, pH value is adjusted between 4.0-5.5 with pH adjusting agent, and preservative is added, stirs 0.5 hour, liquid dressing is made；
(3) dressing is sub-packed in container according to product specification (in bottle or hose), the dressing is made.
Embodiment 2
A kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent it is as follows：
Polymer hyaluronic acid sodium 0.4%, kayexalate 4%, xanthans 0.4%, Sodium Polyacrylate 0.3%,
Carbomer 0.8%, the transparent sour sodium 0.4% of low molecule, amino acid humectant 2% hydrolyze glycosaminoglycan 1.5%, reed fragrant plant
Oil 2%, glycerine 4%, propylene glycol 4%, butanediol 6%, Gotu Kola P.E 3%, allantoin 0.8%, preservative 0.1%, pH
Conditioning agent 0.2%, water surplus.
A kind of preparation method of the potent moisture-preserving dressing with epidermis repair function comprising following steps：
(1) each component is weighed by formula ratio, by polymer hyaluronic acid sodium, carbomer, the transparent sour sodium of low molecule, allantois
Element, xanthans, Sodium Polyacrylate, glycerine, propylene glycol, butanediol are added to the water, and pH value is adjusted to 9.0-9.5 with pH adjusting agent
Between, kayexalate is added, stirring and dissolving, warming while stirring is to 80-95 degrees Celsius, then reacts 1 hour, so
Postcooling is to 35 degrees Celsius, and obtained mixture A is spare；
(2) by Gotu Kola P.E, amino acid humectant, reed fragrant plant is oily, and hydrolysis glycosaminoglycan is added to mixture A
In, pH value is adjusted between 5.5-7.0 with pH adjusting agent, and preservative is added, stirs 1 hour, liquid dressing is made；
(3) dressing is sub-packed in container according to product specification (in bottle or hose), the dressing is made.
It can be observed under Electronic Speculum have three-dimensional netted supporting structure, such as Fig. 1 inside the dressing made from the above experimental procedure
Shown, wherein label 1 indicates cell (white bright spot part is cell, rounded, oval or irregular similar round).
Embodiment 3
A kind of potent moisture-preserving dressing with epidermis repair function, including constituent content weight percent it is as follows：
Polymer hyaluronic acid sodium 2%, kayexalate 8%, xanthans 2%, Sodium Polyacrylate 2%, carbomer
3%, the transparent sour sodium 2% of low molecule, amino acid humectant 6% hydrolyzes glycosaminoglycan 5%, reed fragrant plant oil 6%, glycerine
10%, propylene glycol 10%, butanediol 12%, Gotu Kola P.E 8%, allantoin 3%, preservative 0.4%, pH adjusting agent 1%,
Water surplus.
A kind of preparation method of the potent moisture-preserving dressing with epidermis repair function comprising following steps：
(1) each component is weighed by formula ratio, by polymer hyaluronic acid sodium, carbomer, the transparent sour sodium of low molecule, allantois
Element, xanthans, Sodium Polyacrylate, glycerine, propylene glycol, butanediol are added to the water, and pH value is adjusted to 9.5-10 with pH adjusting agent
Between, kayexalate is added, stirring and dissolving, warming while stirring is to 95 degrees Celsius, then reacts 2 hours, then
45 degrees Celsius are cooled to, obtained mixture A is spare；
(2) by Gotu Kola P.E, amino acid humectant, reed fragrant plant is oily, and hydrolysis glycosaminoglycan is added to mixture A
In, pH value is adjusted between 7.0-8.0 with pH adjusting agent, and preservative is added, stirs 1.5 hours, liquid dressing is made；
(3) dressing is sub-packed in container according to product specification (in bottle or hose), the dressing is made.
Product measure of merit
1. test object：The patient of skin damage 120, each 60 of men and women, the age is from 10-65 Sui.
2. test method：120 patients are randomly divided into 4 groups, every group 30, A groups are used and applied described in the embodiment of the present invention 2
Material, B groups with it is commercially available certain lay claim to skin moisture-keeping and the well-known skin care item of skin repair effect, C groups are with commercially available another kind a surname
Title has skin moisture-keeping and the well-known skin care item of skin repair effect, D groups to do blank control.Sooner or later each coating is primary, is washed before coating
Net damaged skin surface carried out first time further consultation using 1 day, is used continuously and carries out within 3 days second of further consultation, continuous use 5 days into
Row third time further consultation is used continuously 7 days and carries out the 4th further consultation.
3. effect assessment：
(1) effective：Red swelling of the skin, itch, it is dry taut, tight it is puckery, obscure, pore is coarse, microgroove, equivalent damage phenomenon disappear.
(2) effectively：Red swelling of the skin, itch, it is dry taut, tight it is puckery, obscure, pore is coarse, microgroove, equivalent damage phenomenon mitigate.
(3) invalid：Red swelling of the skin, itch, it is dry taut, tight it is puckery, obscure, pore is coarse, microgroove, equivalent damage phenomenon become without apparent
Change.
(4) it aggravates：Red swelling of the skin, itch, it is dry taut, tight it is puckery, obscure, pore is coarse, microgroove, equivalent damage phenomenon aggravate.
4. treatment results are listed in table 1.
Table 1：Treatment results
From A, tri- groups for the treatment of results of B, C are as it can be seen that 5 days cure rates of A groups are 29/30=96.7%, the healing in 5 days of B groups and C groups
Rate is 18/30=60.0%, 12/30=40.0% respectively.Show that the product effect of the present invention is faster and better.Commercially available product has
The effect of skin, but slowly effect are repaired in certain moisturizing.D groups have 5 patient skin damaged phenomenons without significant change after 1 day, this
The recovery function that may have benefited from human skin itself can resist skin damage deterioration, but after the time extending to 3 days, be damaged
Phenomenon aggravates (for patient health, blank control test is no longer done after 3 days), and hint leans on autologous skin repair ability to be completely can not
It takes, skin damage still will choose appropriate therapeutic modality and be treated in time.
Claims (10)
1. a kind of potent moisture-preserving dressing with epidermis repair function, which is characterized in that including constituent content percentage by weight
Number is as follows：Polymer hyaluronic acid sodium 0.03%-2%, kayexalate 0.03%-8%, xanthans 0.03%-2%,
Sodium Polyacrylate 0.02%-2%, carbomer 0.05%-3%, the transparent sour sodium 0.03%-2% of low molecule, amino acid humectant
0.2%-6% hydrolyzes glycosaminoglycan 0.01%-5%, reed fragrant plant oil 0.3%-6%, glycerine 1%-10%, propylene glycol
0.5%-10%, butanediol 0.5%-12%, Gotu Kola P.E 0.1%-8%, allantoin 0.01%-3%, preservative
0.01%-0.4%, pH adjusting agent 0.01%-1%, water surplus；
The polymer hyaluronic acid sodium molecule amount is between 600,000-150 ten thousand, and the transparent sour sodium molecule amount of low molecule is in 8000-
Between 100000.
2. the potent moisture-preserving dressing according to claim 1 with epidermis repair function, which is characterized in that including component
Content weight percent is as follows：Polymer hyaluronic acid sodium 0.05%-1%, kayexalate 0.04%-6%, xanthan
Glue 0.05%-1%, Sodium Polyacrylate 0.04%-1%, carbomer 0.1%-2%, the transparent sour sodium 0.05%-1% of low molecule,
Amino acid humectant 0.4%-5% hydrolyzes glycosaminoglycan 0.01%-4%, reed fragrant plant oil 0.5%-4%, glycerine 1%-8%,
Propylene glycol 1%-8%, butanediol 1%-10%, Gotu Kola P.E 0.1%-6%, allantoin 0.01%-2%, preservative
0.01%-0.4%, pH adjusting agent 0.01%-1%, water surplus.
3. the potent moisture-preserving dressing according to claim 1 with epidermis repair function, which is characterized in that including component
Content weight percent is as follows：Polymer hyaluronic acid sodium 0.05%-0.5%, kayexalate 0.05%-5%, it is yellow
Virgin rubber 0.05%-0.5%, Sodium Polyacrylate 0.05%-0.5%, carbomer 0.1%-1%, the transparent sour sodium of low molecule
0.05%-0.5%, amino acid humectant 0.5%-3% hydrolyze glycosaminoglycan 0.01%-2%, reed fragrant plant oil 0.5%-
3%, glycerine 1%-5%, propylene glycol 1%-5%, butanediol 1%-8%, Gotu Kola P.E 0.1%-5%, allantoin
0.01%-1%, preservative 0.01%-0.4%, pH adjusting agent 0.01%-1%, water surplus.
4. the potent moisture-preserving dressing according to claim 1 with epidermis repair function, which is characterized in that including component
Content weight percent is as follows：Polymer hyaluronic acid sodium 0.4%, kayexalate 4%, xanthans 0.4%, poly- third
Olefin(e) acid sodium 0.3%, carbomer 0.8%, the transparent sour sodium 0.4% of low molecule, amino acid humectant 2%, hydrolysis glucose amino are poly-
Sugar 1.5%, reed fragrant plant oil 2%, glycerine 4%, propylene glycol 4%, butanediol 6%, Gotu Kola P.E 3%, allantoin 0.8% are prevented
Rotten agent 0.1%, pH adjusting agent 0.2%, water surplus.
5. the potent moisture-preserving dressing with epidermis repair function according to any one of claim 1-4, which is characterized in that
The polymer hyaluronic acid sodium, kayexalate, xanthans, Sodium Polyacrylate and carbomer build three-dimensional netted holder
Structure.
6. a kind of preparation side of the potent moisture-preserving dressing according to any one of claims 1-5 with epidermis repair function
Method, which is characterized in that include the following steps：
(1) each component is weighed by formula ratio, by polymer hyaluronic acid sodium, carbomer, the transparent sour sodium of low molecule, allantoin,
Xanthans, Sodium Polyacrylate, glycerine, propylene glycol, butanediol are added to the water, with pH adjusting agent adjust pH value to 8.5-10 it
Between, kayexalate is added, stirring and dissolving is warming up to 80-95 degrees Celsius, then reacts 0.5-2 hour, then cools down
To 15-45 degrees Celsius, obtained mixture A is spare；
(2) by Gotu Kola P.E, amino acid humectant, reed fragrant plant is oily, and hydrolysis glycosaminoglycan is added in mixture A, is used
PH adjusting agent adjusts pH value between 4.0-8.0, and preservative is added, stirs 0.5-1.5 hour, the dressing is made.
7. the preparation method of the potent moisture-preserving dressing according to claim 6 with epidermis repair function, which is characterized in that
PH value is adjusted to 9.0-9.5 with pH adjusting agent in step (1).
8. the preparation method of the potent moisture-preserving dressing according to claim 6 with epidermis repair function, which is characterized in that
Stirring and dissolving in step (1), is warming up to 82-87 degrees Celsius.
9. the preparation method of the potent moisture-preserving dressing according to claim 6 with epidermis repair function, which is characterized in that
The time reacted again in step (1) is 0.8-1.5 hour.
10. a kind of application of the potent moisture-preserving dressing according to any one of claims 1-5 with epidermis repair function,
It is characterized in that, the dressing is applied to skin care applications.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810648442.5A CN108567638B (en) | 2018-06-22 | 2018-06-22 | Moisturizing dressing with epidermis repairing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810648442.5A CN108567638B (en) | 2018-06-22 | 2018-06-22 | Moisturizing dressing with epidermis repairing function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108567638A true CN108567638A (en) | 2018-09-25 |
| CN108567638B CN108567638B (en) | 2021-06-29 |
Family
ID=63573507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810648442.5A Active CN108567638B (en) | 2018-06-22 | 2018-06-22 | Moisturizing dressing with epidermis repairing function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108567638B (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578327A (en) * | 2018-07-15 | 2018-09-28 | 海南侯臣生物科技有限公司 | A kind of mountain shaddock moisture saver mask and preparation method thereof |
| CN109568203A (en) * | 2018-12-18 | 2019-04-05 | 诺斯贝尔化妆品股份有限公司 | A kind of cosmetic composition with whitening skin lightening |
| CN109674686A (en) * | 2019-01-22 | 2019-04-26 | 华熙福瑞达生物医药有限公司 | A kind of composition and preparation method thereof of maintenance damaged skin |
| CN111281646A (en) * | 2020-03-28 | 2020-06-16 | 广州市赛迪药业科技有限公司 | Production process of medical cold compress patch |
| CN111374904A (en) * | 2018-12-29 | 2020-07-07 | 好维股份有限公司 | Oral care composition |
| CN111658818A (en) * | 2020-06-23 | 2020-09-15 | 湖南美媛本草生物工程有限公司 | Medical repair dressing and application thereof |
| CN111904888A (en) * | 2020-09-23 | 2020-11-10 | 海南希睿达生物技术有限公司 | Ceramide-containing medical dressing for skin barrier protection and preparation method thereof |
| CN112190518A (en) * | 2020-10-30 | 2021-01-08 | 昝小华 | Whitening and moisturizing mask and preparation method thereof |
| WO2022248361A1 (en) * | 2021-05-26 | 2022-12-01 | Almirall, S.A. | Pharmaceutical composition comprising a centella asiatica extract |
| CN115919686A (en) * | 2022-11-20 | 2023-04-07 | 天津郁美净集团有限公司 | Skin soothing lotion for enhancing skin barrier and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN107007876A (en) * | 2017-06-02 | 2017-08-04 | 江苏昌吉永生物科技股份有限公司 | Hyaluronic acid medical aseptic dressing and preparation method thereof |
| CN107137760A (en) * | 2017-05-27 | 2017-09-08 | 河南汇博医疗股份有限公司 | A kind of moisturizing maintenance dressing and preparation method thereof |
-
2018
- 2018-06-22 CN CN201810648442.5A patent/CN108567638B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN107137760A (en) * | 2017-05-27 | 2017-09-08 | 河南汇博医疗股份有限公司 | A kind of moisturizing maintenance dressing and preparation method thereof |
| CN107007876A (en) * | 2017-06-02 | 2017-08-04 | 江苏昌吉永生物科技股份有限公司 | Hyaluronic acid medical aseptic dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 广州魅瑟生物科技有限公司: "《花田美芙玻尿酸精华原液》", 7 May 2018, 国产非特殊用于化妆品备案信息服务平台HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20180419102050WFC62&NID=20180419102050WFC62 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578327A (en) * | 2018-07-15 | 2018-09-28 | 海南侯臣生物科技有限公司 | A kind of mountain shaddock moisture saver mask and preparation method thereof |
| CN109568203B (en) * | 2018-12-18 | 2021-12-10 | 诺斯贝尔化妆品股份有限公司 | Cosmetic composition with whitening and skin brightening effects |
| CN109568203A (en) * | 2018-12-18 | 2019-04-05 | 诺斯贝尔化妆品股份有限公司 | A kind of cosmetic composition with whitening skin lightening |
| CN111374904A (en) * | 2018-12-29 | 2020-07-07 | 好维股份有限公司 | Oral care composition |
| CN111374904B (en) * | 2018-12-29 | 2023-02-28 | 好维股份有限公司 | Oral care composition |
| CN109674686A (en) * | 2019-01-22 | 2019-04-26 | 华熙福瑞达生物医药有限公司 | A kind of composition and preparation method thereof of maintenance damaged skin |
| CN109674686B (en) * | 2019-01-22 | 2022-05-31 | 华熙生物科技股份有限公司 | Composition for repairing damaged skin and preparation method thereof |
| CN111281646A (en) * | 2020-03-28 | 2020-06-16 | 广州市赛迪药业科技有限公司 | Production process of medical cold compress patch |
| CN111658818A (en) * | 2020-06-23 | 2020-09-15 | 湖南美媛本草生物工程有限公司 | Medical repair dressing and application thereof |
| CN111904888A (en) * | 2020-09-23 | 2020-11-10 | 海南希睿达生物技术有限公司 | Ceramide-containing medical dressing for skin barrier protection and preparation method thereof |
| CN111904888B (en) * | 2020-09-23 | 2022-09-16 | 海南希睿达生物技术有限公司 | Ceramide-containing medical dressing for skin barrier protection and preparation method thereof |
| CN112190518A (en) * | 2020-10-30 | 2021-01-08 | 昝小华 | Whitening and moisturizing mask and preparation method thereof |
| WO2022248361A1 (en) * | 2021-05-26 | 2022-12-01 | Almirall, S.A. | Pharmaceutical composition comprising a centella asiatica extract |
| CN115919686A (en) * | 2022-11-20 | 2023-04-07 | 天津郁美净集团有限公司 | Skin soothing lotion for enhancing skin barrier and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108567638B (en) | 2021-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108567638A (en) | A kind of potent moisture-preserving dressing with epidermis repair function | |
| CN104587518B (en) | Hyaluronic acid dressing and preparation method thereof | |
| CN106822988B (en) | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch | |
| CN106265348A (en) | A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application | |
| CN107007876A (en) | Hyaluronic acid medical aseptic dressing and preparation method thereof | |
| CN108686255B (en) | Biological dressing for preventing scar formation and preparation method thereof | |
| CN107137760A (en) | A kind of moisturizing maintenance dressing and preparation method thereof | |
| CN105902461A (en) | Essence containing snail mucus extracts and preparation method thereof | |
| CN105012228A (en) | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition | |
| CN107982180A (en) | A kind of anti-inflammatory antiallergic mask and preparation method thereof | |
| CN110302086A (en) | A kind of multiple-effect maintenance essence and its preparation process | |
| CN109223618A (en) | A kind of hyaluronic acid Essence and preparation method thereof | |
| CN109363989A (en) | A kind of antiallergic repairs facial mask and preparation method thereof | |
| CN109330912A (en) | Beautifying skin remediation composition and facial mask | |
| CN107899003A (en) | A kind of chitosan oligomer medical wound nursing film and preparation method thereof | |
| CN109394612A (en) | Facial mask and preparation method thereof is repaired in a kind of moisturizing | |
| CN113975197B (en) | Composition containing sodium polyglutamate and dressing applied by composition | |
| CN114903981A (en) | Wound repair formula containing recombinant type III collagen | |
| WO2014190179A2 (en) | Urea silicon gel for scars and hydration treatment and method of using same | |
| US20140348873A1 (en) | Urea-Silicone Gel for Hyperkeratosis Treatment | |
| CN116196250B (en) | Recombinant collagen freeze-dried mask with repairing effect and preparation method thereof | |
| CN110496069A (en) | A kind of poly- peptide stoste of small molecule and preparation method thereof | |
| CN113750286B (en) | Skin wound covering film and preparation method thereof | |
| CN108721162A (en) | A kind of smooth essence breast of agalloch eaglewood and preparation method thereof | |
| CN104474577A (en) | Laser beatifying postoperation dressing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Qian Jiehao Inventor before: Lu Guiping Inventor before: Qian Jiehao Inventor before: Zhong Riying Inventor before: He Bing Inventor before: He Liyuan |
|
| CB03 | Change of inventor or designer information | ||
| CB02 | Change of applicant information |
Address after: No.756, xiangtian Road, Jinwan District, Zhuhai City, Guangdong Province Applicant after: ZHUHAI YASHA MEDICAL DEVICES Co.,Ltd. Address before: Nanping Town Xiangzhou District Guangdong city Zhuhai province 519060 Guang Sheng Industrial Zone No. 45 Guang Sheng Lu four floor Applicant before: ZHUHAI YASHA MEDICAL DEVICES Co.,Ltd. |
|
| CB02 | Change of applicant information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |