CN107137760A - A kind of moisturizing maintenance dressing and preparation method thereof - Google Patents
A kind of moisturizing maintenance dressing and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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Abstract
The present invention relates to functional dressing technical field, and in particular to a kind of moisturizing maintenance dressing and preparation method thereof.The dressing is made up of following raw material：Low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid, triethanolamine, NMF, lubricant, gel-type vehicle, emulsifying agent, preservative.The dressing is used cooperatively by low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid and gel-type vehicle, assign product excellent moisture retention, the instant moisture retention of product (30min) is up to 90%, and long-acting moisture retention (24h) is up to 70%.Hyaluronic acid is used cooperatively with polyglutamic acid, mitigates scytitis, is repaired skin moisture barrier, is persistently kept the moisture of skin.Dressing of the present invention can be in skin surface one moisture barrier of formation, prevent injury of the extraneous poor environment to skin, one moist environment can also be provided for inner skin, skin surface moisture loss is reduced, promote to give skin lubricious sense of touch outside skin surface wound healing.
Description
Technical field
The present invention relates to functional dressing technical field, and in particular to a kind of moisturizing maintenance dressing and preparation method thereof.
Background technology
With the development and progress in epoch, Minimally Invasive Surgery is led so that its wound is small, pain is light, recover fast advantage into each
Domain, as one kind of skin Minimally Invasive Surgery, the optics beauty such as photon delicate skin, Caisf Nfneu and laser beautifying Minimally Invasive Surgery is also increasingly
Generally.However, the skin after optics beauty also becomes abnormal fragile, easily occur water shortage, pigmentation, bubble, decolouring, erythema,
The symptoms such as inflammation, skin burns.
In addition, with the variation of living environment, the decline of ozone layer and the increase of job and life stress, the kind of skin problem
Class is more and more.In the winter especially dried in cold, on the one hand because air is more dried and sharp cold wind, cause skin table
The moisture in face accelerates to be pulled away, on the other hand, because temperature is low, and the secretion for making to sweat with sebum is reduced, and finally makes transepidermal water
Supply it is also relative reduce, cause skin surface to be dried, and then trigger a series of skin problems such as itch, decortication, fash.Thus
No matter men and women, old and young, autumn and winter all it is possible that a series of skin problems caused by drying, such as itch, it is coarse, chap,
Furfur etc..
Other dries dermatoses such as the position sebaceous glands such as ichthyosis, psoriasis, scar and sweat gland severe atrophy, causes
The secretion for making to sweat with sebum is reduced, and causes the supply of transepidermal water is relative to reduce, final to trigger the symptoms such as drying, itch, is given
Patient brings the double burden of body ＆ mind.
For problem above, people are often using the moisturizer of some basic nursing types to prevent or alleviate these
The generation of problem.But current Moisturizer is protected mostly containing compositions such as essence, mineral oil, hormone, pigments giving skin
Wet effect also produces stimulation to skin simultaneously, and hidden danger is brought to skin.And for the fragile skin of psoriasis class, with greater need for gentle
Non-stimulated product is takeed good care of, and the requirement to the instant moisture retention and long-acting moisture retention of moisturizing nursing product is also of a relatively high.
The A of Chinese patent CN 104013639 disclose a kind of composition and its gel with skin repair function, should
Gel disclosed in patent is using gelatin, hydroxyethyl cellulose and Acritamer 940 as gel-type vehicle, with glycerine, propane diols and 1,3-
Butanediol is moisturizing ingredient, and adds the auxiliary agents such as chitosan, trehalose, although with antibacterial promoting healing function, but moisture retention,
Wetability is short of, weak for the dermopathic nursing efficacy of the drying property such as ichthyosis, psoriasis, scar.
The A of Chinese patent CN 103191461 disclose a kind of wound care dressing containing hyaluronic acid, the patent utilization
High molecular weight hyaluronic acid, low-molecular-weight hyaluronic acid coordinate soluble silver salt to be prepared for material and can be used for various skin wounds, burst
The sterilizing of ulcer etc., anti-infective and healing acceleration wound dressing.Although by adding high molecular weight hyaluronic acid in the dressing
With low-molecular-weight hyaluronic acid so that dressing has certain moisture-keeping function, but it is not notable enough to continue performance of keeping humidity, it is impossible to full
Sufficient ichthyosis, psoriasis and scar etc. dry demand of the dermatoses to continuation moisturizing.
Chinese patent CN104586705A discloses a kind of facial treatment essence liquid, and the Essence includes small molecule hyalomitome
The composition such as acid, hyaluronic acid, polyglutamic acid sodium and some NMFs, plant extraction liquid and essential oil, although added in the Essence
Low molecular weight hyaluronic acid, hyaluronic acid, polyglutamic acid and other small molecule NMF compositions have been used to assign Essence to protect
Wet performance, but the instantaneous moistening effect of moisturizer of this Essence form is significantly, but without lasting performance of keeping humidity.
Accordingly, it would be desirable to develop a kind of both with good moisture retention immediately, it is again safe, non-stimulated with long-acting moisture retention
Moisturizing maintenance dressing, to meet the demand of different skin problem, becomes technical problem urgently to be resolved hurrily at present.
The content of the invention
In order to overcome the defect of prior art, dressing is repaired it is an object of the invention to provide a kind of moisturizing, with significant
Instant moisture retention and performance of keeping humidity, and it is safe and reliable non-stimulated, it disclosure satisfy that the demand of different skin problem.
Meanwhile, the present invention, which is also resided in, provides the preparation method that dressing is repaired in a kind of moisturizing.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid 0.01~
5%th, polymer hyaluronic acid 0.01~5%, polyglutamic acid 0.01~5%, triethanolamine 0.01~2%, NMF 0.01~
40%th, lubricant 0.1~25%, gel-type vehicle 0.1~5%, emulsifying agent 0.01~5%, preservative 0.01~2%, surplus is
Water.
It is preferred that, above-mentioned moisturizing maintenance dressing is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.1~2%, polymer hyaluronic acid 0.1~2%, polyglutamic acid 0.1~2%, triethanolamine 0.1~2%, NMF 10~
35%th, lubricant 5~20%, gel-type vehicle 0.1~3%, emulsifying agent 0.1~1%, preservative 0.1~1%, surplus is water.
Optionally, the gel-type vehicle is Acritamer 940, hydroxyethyl cellulose, sodium carboxymethylcellulose, gelatin, xanthan
One kind or any combination in glue.
It is preferred that, the gel-type vehicle is Acritamer 940 and hydroxyethyl cellulose according to 2：1 mixture.
Optionally, the NMF is one kind or any combination in glycerine, polyethylene glycol, cetostearyl alcohol, propane diols.
It is preferred that, the NMF is glycerine, polyethylene glycol according to 5：0.5 mixture.
Optionally, the molecular weight of the polymer hyaluronic acid is 80~1,800,000.
It is preferred that, the molecular weight of the polymer hyaluronic acid is 100~1,500,000.
Optionally, the molecular weight of the low molecular weight hyaluronic acid is 10~500,000.
It is preferred that, the molecular weight of the low molecular weight hyaluronic acid is 20~400,000.
Optionally, the molecular weight of the polyglutamic acid is 50~1,500,000.
It is preferred that, the molecular weight of the polyglutamic acid is 60~1,000,000.
Optionally, the emulsifying agent be Tween 80, polysorbate60, sorbester p17, sorbester p18, isomerous tridecanol polyoxyethylene ether,
One kind or arbitrary composition in heterogeneous ten alcohol polyoxyethylene ether, poloxamer.The lubricant is silicone oil and/or vegetable oil.
Optionally, the preservative is nipagin esters, nipagin esters salt, Kathon CG, IPBC
In one kind or any combination.
The preparation method of above-mentioned moisturizing maintenance dressing, including following operating procedure：
1) take gel-type vehicle to add to be swelled in the water of part, be sufficiently stirred for dissolving, it is standby as component A；
2) low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid and water soluble humectants are dissolved in remaining water
In, it is sufficiently stirred for dissolving, is well mixed, it is standby as B component；
3) by emulsifying agent add step 2) prepare B component in, after stirring and dissolving, under stirring add oil-soluble protect
Humectant, lubricant, after being well mixed, sequentially add preservative and component A, after being thoroughly mixed uniformly, add triethanolamine,
It is 5~7 to adjust pH, and stirring is removed bubble removing, that is, completed.
Above-mentioned water is deionized water.
Moisturizing maintenance dressing of the present invention, with low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid attached gel base
Matter, and add NMF, preservative, lubricant, emulsifying agent, triethanolamine etc. and be prepared from for raw material, compared with prior art
Have the advantages that：
1st, low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid compounding use, and in the effect of gel-type vehicle
Under, promote each component to play synergistic function, assign product excellent instant moisture retention and long-acting moisture retention：Hyaluronic acid is
The main component of the connective tissues such as human body cell interstitial, vitreum, knuckle synovia is constituted, water conservation is played in vivo, remains thin
External space of cell, regulation osmotic pressure, lubrication, the important physiological function for promoting cell repair.Containing substantial amounts of in hyaluronan molecule
Carboxyl and hydroxyl, form intramolecular and intermolecular hydrogen bond, this makes it have powerful water retention, can combine in aqueous
Itself 500-1000 times of water；In higher concentration, due to the complicated three-level network structure of its intermolecular interaction formation, its water
Solution has significant viscoplasticity again.Macromolecular hyaluronic acid has suppression to make signaling, propagation, differentiation and phagocytic function
With micromolecule hyaluronic acid then has facilitation.Hyaluronic acid acts on skin surface, and macromolecular hyaluronic acid can be in skin table
Face forms one layer of ventilative film, moistens skin smooth, and can obstruct the intrusion of alien bacteria, dust, ultraviolet, protects skin
Skin is from encroaching on, and the skin that compacts, permanent moisturizing；Micromolecule hyaluronic acid can then penetrate into corium, with mild dilation blood capillary
Pipe, increase blood circulation, improvement intermediate supersession, promotion skin-nourishing absorption, with stronger wrinkle-chasing function, can increase skin
Skin elasticity, delay skin aging.
Polyglutamic acid is a kind of natural polymer of water miscible special anion, is between α-amido and γ-carboxyl
Constituted homotype polyamide is bonded through acid amides, molecular weight is from 5 ten thousand to 2 megadaltons, and its moisturizing water lock effect is
500 times of bright matter acid.Molecular structure special γ-PGA, makes it have extremely strong moisture-retaining capacity, γ-PGA are in cosmetics for addition
Or in skin care products, can effectively increase the moisture-retaining capacity of skin, promote skin health.Polyglutamic acid and micromolecule hyaluronic acid knot
Conjunction is used, and the performance that micromolecule hyaluronic acid penetrates into corium can promote percutaneous absorption polyglutamic acid, lift the moisture retention of product
Energy.
Addition uses gel-type vehicle so that polyglutamic acid, polymer hyaluronic acid and low molecular weight hyaluronic acid can be slow
Performance of keeping humidity is discharged, and can be reduced skin surface moisture loss in skin surface formation thin film, lift the length of product
Performance of keeping humidity is imitated, and isolates outside poor environment such as bacterium, sensibiligen and is injured, the wettability of the surface of a wound can be kept again, mitigates scorching
Disease is reacted.
2nd, by adding lubricant, assign product excellent lubricity, make skin lubricious simultaneously, allow product by by
Rub and use, such a occupation mode had both expanded the use approach of product, can also by massage stimulate circulation with accelerate nutrition into
Divide and absorb.
3rd, the present invention using low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid, coordinate NMF, lubricant,
Gel-type vehicle prepares moisturizing maintenance dressing, the natural moisture preserving system that simulation human skin is made up of oil, water, NMF
System, can form the film of densification in skin surface, prevent deep skin moisture evaporation, cuticula itself aquation, and cutin-softening,
Increase moisture content of skin, reduce psoriasis, the scales of skin that peel off of ichthyosis and produce, mitigate the pruritis of people with xerosis.
4th, medical moisturized maintenance gel dressing of the invention is without compositions, gentle nothing such as pigment, essence, alcohol, mineral oil
Stimulate.
5th, the instant moisture retention (30min) of dressing of the present invention is up to 90%, and long-acting moisture retention (24h) is up to 70%.
Embodiment
Technical scheme is described in detail below by specific embodiment.
Embodiment 1
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.01%th, polymer hyaluronic acid 4%, polyglutamic acid 5%, triethanolamine 1%, NMF 0.01%, lubricant 10%, gel
Matrix 2%, emulsifying agent 5%, preservative 0.01%, surplus is deionized water；
Wherein NMF is intervention；Lubricant is silicone oil；Gel-type vehicle is Acritamer 940；Emulsifying agent is isomerous tridecanol
APEO；Preservative is nipagin esters；
Wherein the molecular weight of low molecular weight hyaluronic acid is 400,000；The molecular weight of polymer hyaluronic acid is 1,500,000；Polyglutamic
The molecular weight of acid is 1,000,000.
The preparation method of above-mentioned moisturizing maintenance dressing, including following operating procedure：
1) take gel-type vehicle to add to be swelled in the water of part, be sufficiently stirred for dissolving, it is standby as component A；
2) low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid and water soluble humectants are dissolved in remaining water
In, it is sufficiently stirred for dissolving, is well mixed, it is standby as B component；
3) by emulsifying agent add step 2) prepare B component in, after stirring and dissolving, under stirring add oil-soluble protect
Humectant, lubricant, after being well mixed, sequentially add preservative and component A, after being thoroughly mixed uniformly, add triethanolamine,
It is 5~7 to adjust pH, and stirring is removed bubble removing, that is, completed.
Embodiment 2
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid 5%,
Polymer hyaluronic acid 0.01%, polyglutamic acid 0.01%, triethanolamine 0.5%, NMF 10%, lubricant 0.1%, gel
Matrix 0.1%, emulsifying agent 4%, preservative 0.5%, surplus is deionized water；
Wherein NMF is glycerine, polyethylene glycol and propane diols according to 1：2：1 mixture；Lubricant is vegetable oil and silicon
The mixture of oil；Gel-type vehicle is hydroxyethyl cellulose；Emulsifying agent is the mixture of Tween 80 and polysorbate60；Preservative is card
Pine；
Wherein the molecular weight of low molecular weight hyaluronic acid is 200,000；The molecular weight of polymer hyaluronic acid is 1,000,000；Polyglutamic
The molecular weight of acid is 600,000.
The preparation method be the same as Example 1 of the present embodiment moisturizing maintenance dressing.
Embodiment 3
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.5%th, polymer hyaluronic acid 2%, polyglutamic acid 2%, triethanolamine 2%, NMF 40%, lubricant 5%, gel-type vehicle
5%th, emulsifying agent 2%, preservative 1%, surplus is deionized water；
Wherein NMF is cetostearyl alcohol and propane diols according to 2：1 mixture；Lubricant is vegetable oil and silicone oil
Mixture；Gel-type vehicle is gelatin；Emulsifying agent is the mixture of sorbester p17 and poloxamer；Preservative is iodo propinyl butyl
Carbamate；
Wherein the molecular weight of low molecular weight hyaluronic acid is 500,000；The molecular weight of polymer hyaluronic acid is 800,000；Polyglutamic
The molecular weight of acid is 1,500,000.
The preparation method be the same as Example 1 of the present embodiment moisturizing maintenance dressing.
Embodiment 4
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.1%th, polymer hyaluronic acid 2%, polyglutamic acid 0.8%, triethanolamine 0.01%, NMF 35%, lubricant 20%, solidifying
Gel matrix 1%, emulsifying agent 1%, preservative 2%, surplus is deionized water；
Wherein NMF is polyethylene glycol and propane diols according to 1：2 mixture；Lubricant is the mixed of vegetable oil and silicone oil
Compound；Gel-type vehicle is the mixture of gelatin and xanthans；Emulsifying agent is poloxamer:；Preservative is nipagin esters salt；
Wherein the molecular weight of low molecular weight hyaluronic acid is 100,000；The molecular weight of polymer hyaluronic acid is 1,800,000；Polyglutamic
The molecular weight of acid is 500,000.
The preparation method be the same as Example 1 of the present embodiment moisturizing maintenance dressing.
Embodiment 5
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid 2%,
Polymer hyaluronic acid 0.1%, polyglutamic acid 3%, triethanolamine 0.8%, NMF 20%, lubricant 25%, gel-type vehicle
4%th, emulsifying agent 0.01%, preservative 0.1%, surplus is deionized water；
Wherein NMF is glycerine and polyethylene glycol according to 5：0.5 mixture；Lubricant is the mixed of vegetable oil and silicone oil
Compound；Gel-type vehicle is Acritamer 940 and hydroxyethyl cellulose according to 2：1 mixture；Emulsifying agent is the alcohol polyoxy second of isomery ten
Alkene ether；Preservative is Kathon CG；
Wherein the molecular weight of low molecular weight hyaluronic acid is 300,000；The molecular weight of polymer hyaluronic acid is 1,200,000；Polyglutamic
The molecular weight of acid is 800,000.
The preparation method be the same as Example 1 of the present embodiment moisturizing maintenance dressing.
Embodiment 6
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid 2%,
Polymer hyaluronic acid 5%, polyglutamic acid 0.1%, triethanolamine 0.1%, NMF 22%, lubricant 18%, gel-type vehicle
3%th, emulsifying agent 0.1%, preservative 0.08%, surplus is deionized water；
Wherein NMF is glycerine and polyethylene glycol according to 5：0.5 mixture；Lubricant is the mixed of vegetable oil and silicone oil
Compound；Gel-type vehicle is Acritamer 940 mixture；Emulsifying agent is heterogeneous ten alcohol polyoxyethylene ether；Preservative is Kathon CG；
Wherein the molecular weight of low molecular weight hyaluronic acid is 300,000；The molecular weight of polymer hyaluronic acid is 1,200,000；Polyglutamic
The molecular weight of acid is 800,000.
Embodiment 7
The present embodiment moisturizing maintenance dressing, is made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.2%th, polymer hyaluronic acid 0.2%, polyglutamic acid 5%, triethanolamine 1%, NMF 5%, lubricant 10%, gel base
Matter 2%, emulsifying agent 5%, preservative 0.1%, surplus is deionized water；
Wherein NMF is glycerine；Lubricant is silicone oil；Gel-type vehicle is Acritamer 940；Emulsifying agent is isomerous tridecanol
APEO；Preservative is Kathon CG and IPBC；
Wherein the molecular weight of low molecular weight hyaluronic acid is 400,000；The molecular weight of polymer hyaluronic acid is 1,500,000；Polyglutamic
The molecular weight of acid is 1,000,000.
The preparation method be the same as Example 1 of the present embodiment moisturizing maintenance dressing.
Comparative example 1
This comparative example moisturizer, as different from Example 5, saves gel-type vehicle, adjustment low molecular weight hyaluronic acid
Consumption is 4%, and the consumption of polymer hyaluronic acid is 5%, other be the same as Examples 5.
Comparative example 2
This comparative example moisture-preserving dressing, as different from Example 5, saves low molecular weight hyaluronic acid, adjustment polyglutamic acid
Consumption is 7%, other be the same as Examples 5.
Comparative example 3
This comparative example moisture-preserving dressing, as different from Example 5, saves polymer hyaluronic acid, adjustment low molecule is transparent
The consumption of matter acid is 5%, other be the same as Examples 5.
Comparative example 4
This comparative example moisture-preserving dressing, as different from Example 5, saves polyglutamic acid, adjustment low molecular weight hyaluronic acid
Consumption is 7%, other be the same as Examples 5.
Test method：The product for taking the embodiment 1~7 and comparative example 1~4 of equivalent to prepare respectively is placed in 20 DEG C, and silica gel is
In the same dry environment of drier, 24h is placed, the decrement=sample for weighing up product moisture every 30 minutes and 24 hours is original
Weight is weighed after quality-placement, its moisture-holding capacity is calculated：Moisture-holding capacity=product moisture decrement/product original quality, be as a result
Its moisture retention.
Result of the test statistics is as shown in table 1 below：
Table 1
The instant performance of keeping humidity that has been respectively provided with of dressing prepared by embodiment 1~7 is understood by the data in above-mentioned table 1 and long-acting
Performance of keeping humidity, the instant performance of keeping humidity and long-acting performance of keeping humidity of dressing prepared by embodiment 7 is optimal, and wherein prepared by embodiment 1~7
Difference of the dressing between instant performance of keeping humidity and long-acting performance of keeping humidity be due to each component specific species and specific use
Amount is different；
The instant performance of keeping humidity and long-acting performance of keeping humidity of product prepared by the data display embodiment 5 in above-mentioned table 1 are obvious
Better than comparative example 1~4, it can be seen that, gel-type vehicle exist on the premise of, low molecular weight hyaluronic acid, polymer hyaluronic acid,
It can be good at playing synergistic function between polyglutamic acid, lift the instant performance of keeping humidity and long-acting performance of keeping humidity of product.
Claims (9)
1. a kind of moisturizing maintenance dressing, it is characterised in that be made up of the raw material of following weight percent consumption：Low molecular weight hyaluronic acid
0.01~5%, polymer hyaluronic acid 0.01~5%, polyglutamic acid 0.01~5%, triethanolamine 0.01~2%, NMF
0.01~40%, lubricant 0.1~25%, gel-type vehicle 0.1~5%, emulsifying agent 0.01~5%, preservative 0.01~2%,
Surplus is water.
2. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that be made up of the raw material of following weight percent consumption：
Low molecular weight hyaluronic acid 0.1~2%, polymer hyaluronic acid 0.1~2%, polyglutamic acid 0.1~2%, triethanolamine 0.1~
2%th, NMF 10~35%, lubricant 5~20%, gel-type vehicle 0.1~3%, emulsifying agent 0.1~1%, preservative 0.1~
1%, surplus is water.
3. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that the gel-type vehicle is Acritamer 940, ethoxy
One kind or any combination in cellulose, sodium carboxymethylcellulose, gelatin, xanthans.
4. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that the NMF is glycerine, polyethylene glycol, spermaceti
One kind or any combination in stearyl alcohol, propane diols.
5. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that the molecular weight of the polymer hyaluronic acid is 80
~180 ten thousand；The molecular weight of low molecular weight hyaluronic acid is 10~500,000；The molecular weight of polyglutamic acid is 50~1,500,000.
6. moisturizing maintenance dressing as claimed in claim 5, it is characterised in that the molecular weight of the polymer hyaluronic acid is
100~1,500,000；The molecular weight of low molecular weight hyaluronic acid is 20~400,000；The molecular weight of polyglutamic acid is 60~1,000,000.
7. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that the emulsifying agent is Tween 80, polysorbate60, sapn
80th, one kind or any combination in sorbester p18, isomerous tridecanol polyoxyethylene ether, heterogeneous ten alcohol polyoxyethylene ether, poloxamer
Thing；The lubricant is silicone oil and/or vegetable oil.
8. moisturizing maintenance dressing as claimed in claim 1, it is characterised in that the preservative is nipagin esters, nipagin esters
One kind or any combination in salt, Kathon CG, IPBC.
9. a kind of preparation method of moisturizing maintenance dressing as claimed in claim 1, it is characterised in that including following operation step
Suddenly：
1) take gel-type vehicle to add to be swelled in the water of part, be sufficiently stirred for dissolving, it is standby as component A；
2) low molecular weight hyaluronic acid, polymer hyaluronic acid, polyglutamic acid and water soluble humectants are dissolved in remaining water, filled
Divide stirring and dissolving, be well mixed, it is standby as B component；
3) by emulsifying agent add step 2) prepare B component in, after stirring and dissolving, under stirring add oil-soluble moisturizing
Agent, lubricant, after being well mixed, sequentially add preservative and component A, after being thoroughly mixed uniformly, add triethanolamine, adjust
It is 5~7 to save pH, and stirring is removed bubble removing, that is, completed.
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| CN108852900A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | A kind of antibacterial facial mask and preparation method thereof containing tridecanoic peptide |
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| CN110882176A (en) * | 2018-09-11 | 2020-03-17 | 吉林省蓝鼎陆和科技有限公司 | Tridecapeptide repairing and moisturizing mask taking OPC as carrier and manufacturing method thereof |
| CN111150875A (en) * | 2020-02-13 | 2020-05-15 | 华中科技大学同济医学院附属协和医院 | Hydrogel for indwelling needle application and preparation method thereof |
| CN111569137A (en) * | 2020-04-23 | 2020-08-25 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid biological dressing and preparation method thereof |
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| CN108567638A (en) * | 2018-06-22 | 2018-09-25 | 珠海市雅莎医疗器械有限公司 | A kind of potent moisture-preserving dressing with epidermis repair function |
| CN108567638B (en) * | 2018-06-22 | 2021-06-29 | 珠海市雅莎医疗器械有限公司 | Moisturizing dressing with epidermis repairing function |
| CN108852900A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | A kind of antibacterial facial mask and preparation method thereof containing tridecanoic peptide |
| CN110882176A (en) * | 2018-09-11 | 2020-03-17 | 吉林省蓝鼎陆和科技有限公司 | Tridecapeptide repairing and moisturizing mask taking OPC as carrier and manufacturing method thereof |
| CN108852900B (en) * | 2018-09-11 | 2021-12-14 | 吉林省蓝鼎陆和科技有限公司 | Thirteen-peptide-containing antibacterial mask and preparation method thereof |
| CN109432490A (en) * | 2018-10-17 | 2019-03-08 | 苏州汇涵医用科技发展有限公司 | A kind of transparent aquagel and its preparation method and application |
| CN112107724A (en) * | 2019-06-21 | 2020-12-22 | 西安博和医疗科技有限公司 | Liquid dressing and preparation method thereof |
| CN111150875A (en) * | 2020-02-13 | 2020-05-15 | 华中科技大学同济医学院附属协和医院 | Hydrogel for indwelling needle application and preparation method thereof |
| CN111150875B (en) * | 2020-02-13 | 2022-03-11 | 华中科技大学同济医学院附属协和医院 | Hydrogel for indwelling needle application and preparation method thereof |
| CN111569137B (en) * | 2020-04-23 | 2021-12-07 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid biological dressing and preparation method thereof |
| CN111569137A (en) * | 2020-04-23 | 2020-08-25 | 海南芬森医疗器械有限公司 | Gamma-polyglutamic acid biological dressing and preparation method thereof |
| CN111743788A (en) * | 2020-06-29 | 2020-10-09 | 华仁药业股份有限公司 | Collagen dressing containing icodextrin |
| CN112057670A (en) * | 2020-09-30 | 2020-12-11 | 贯皓医疗科技(惠州市)有限公司 | Liquid dressing for wound |
| CN112121032A (en) * | 2020-10-30 | 2020-12-25 | 山东华熙海御生物医药有限公司 | Hydrogel patch for skin care and preparation method thereof |
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