CN109330912A - Beautifying skin remediation composition and facial mask - Google Patents
Beautifying skin remediation composition and facial mask Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of beautifying skin remediation composition and facial masks.The composition includes: natural polysaccharide, the Low-molecular-weight polysaccharide that natural polysaccharide includes the middle-molecular-weihydroxyethyl polysaccharide that molecular weight is the high molecular weight polysaccharide of 200K~800K Da, molecular weight is 10K~100KDa and molecular weight is 200~9500Da；Native protein.Above-mentioned composition is using natural polysaccharide, albumen as Main Components, by the compound of each molecular weight section, not only can provide wet physical barriers reduces the cough and sensibility of minimally invasive skin after doctor's beauty, sterile, moisturizing skin histology repairing environment is provided, it is permeable to different skin histology inducing skin cells growths again, collagen synthesis and collagenous fibres maturation, activation skin itself is promoted to repair function, to have the function that skin-tightening, elasticity restore；And stimulation of the inflammatory reaction to the surface of a wound can be also reduced, have the function of minimally invasive analgesia, anti-inflammatory to skin.
Description
Technical field
The present invention relates to beautifying technique fields, in particular to a kind of beautifying skin remediation composition and facial mask.
Background technique
Medical cosmetology be by medical means, including drug, instrument and operation etc., by reach change human external in the form of,
The a series for the treatment of carried out for the purpose of color and part improve its physiological function, enhance the external aesthetic feeling of human body.The doctor in China
Treat beauty is in that fulminant increases in recent years, breaks through within 2016 125000000000 yuan, doctor's beauty's number has reached 7,590,000 person-times；2017, in
State is more than Brazil, as U.S. second power of whole world doctor for being only second to the U.S., and doctor's beauty's number is more than 10,000,000, and compound speedup reaches
32%.
Common medical cosmetic applications technology includes: the medical cosmetology technology of skin and hair, such as skin, hair, maintenance, text
Body, beautifying face etc.；Physical chemistry beautifying technique, such as laser, freezing, electrotherapy, grinding (mill skin), Chemical peeling (containing Chinese medicine) beauty
Technology；No operation moulding beautifying technique does not cut weight eyelid, injection fillers, liposuction moulding and other body beautification technologies such as.By above-mentioned
Medical aesthetics technology, instrument, articles scientifical use although can achieve maintenance, improve human body appearance and pretty figure purpose,
But its postoperative skin has subtle wound, more sensitivity, and convalescence domestic demand is aided with specific reparation class and cures U.S. product with firm treatment
Effect promotes satisfaction of users.
It is mostly at present conventional facial mask, complicated component, except including hyaluronic acid, collagen with skin repair facial mask after medical cosmetology
Outside the skin repairs class natural materials such as albumen, also contain various other chemical components, for thering is slight tissue to damage after doctor's fine arts,
The skin histology of rdativery sensitive is irritant, and certain chemical components therein also will cause pigment deposition, skin irritation, allergy
Equal adverse reactions, influence to cure U.S. effect and Patient Experience.In addition, the components such as hyaluronic acid, collagen used in conventional facial mask
Mostly unimodal molecular weight, such as hyaluronic acid facial mask, collagen protein face, alginic acid facial mask.And the extracellular matrix in skin histology
Then it is made of composite components such as polysaccharide and albumen, single component is difficult to provide effective cytothesis induction biomimetic environment, and
It is difficult to take into account moisture retention and permeability, cannot achieve the effect that optimal skin histology protection and Regeneration and Repair.
Summary of the invention
The main purpose of the present invention is to provide a kind of beautifying skin remediation composition and facial masks, to solve in the prior art
Conventional facial mask be difficult to take into account moisture retention and infiltrative problem.
To achieve the goals above, one aspect of the invention provides a kind of beautifying skin remediation composition, the composition
Include: natural polysaccharide, natural polysaccharide include molecular weight be the high molecular weight polysaccharide of 200K~800K Da, molecular weight be 10K~
The middle-molecular-weihydroxyethyl polysaccharide and molecular weight of 100KDa is the Low-molecular-weight polysaccharide of 200~9500Da；Native protein.
Further, the molecular weight of above-mentioned high molecular weight polysaccharide is 200K~500K Da, preferably point of middle-molecular-weihydroxyethyl polysaccharide
Son amount is 10K~80K Da, and preferably the molecular weight of Low-molecular-weight polysaccharide is 200~8000Da.
Further, above-mentioned native protein is small molecule native protein, and preferably the molecular weight of small molecule native protein is 200
~10000Da；Preferably 200~5000Da.
Further, in parts by weight, in above-mentioned composition, high molecular weight polysaccharide is 10~40 parts, middle-molecular-weihydroxyethyl polysaccharide
It is 5~20 parts, Low-molecular-weight polysaccharide is 5~30 parts, and native protein is 5~30 parts.
Further, in parts by weight, in above-mentioned composition, high molecular weight polysaccharide is 10~30 parts, middle-molecular-weihydroxyethyl polysaccharide
It is 5~15 parts, Low-molecular-weight polysaccharide is 10~20 parts, and native protein is 10~30 parts.
Further, above-mentioned natural polysaccharide is selected from one kind of the group of hyaluronic acid, sodium alginate, water soluble chitosan composition
Or it is a variety of.
Further, above-mentioned water soluble chitosan be selected from carboxymethyl chitosan, carboxymethyl chitin, hydroxypropyl chitosan,
Hydroxypropyl chitosan, hydroxyethyl chitosan, ethoxyl chitin, hydroxyl butyl chitosan, hydroxyl butyl chitin, chitosan quaternary ammonium
One of salt, chitosan lactate, glutamate, group of sulfated chitosan composition are a variety of.
Further, above-mentioned native protein is selected from collagen, gelatin, elastin, fibroin albumen and respective its and spreads out
One of group of biotic component is a variety of.
According to another aspect of the present invention, a kind of facial mask is provided, including the composition for beautifying skin reparation, the group
Close the composition that object is any of the above-described kind.
Further, above-mentioned facial mask further includes mask sheet, and composition is supported on mask sheet.
It applies the technical scheme of the present invention, the beautifying skin remediation composition of the application is main with natural polysaccharide, albumen
Component can form " exogenous cells assign repair system living ", not only can provide wet physics by the compound of each molecular weight section
Barrier reduces the cough and sensibility of minimally invasive skin after doctor's beauty, it is possible to provide sterile, moisturizing skin histology repairing environment, and can
It infiltrates into different skin histology inducing skin cells growths, promote collagen synthesis and collagenous fibres maturation, activation skin
Itself repairs function, to have the function that skin-tightening, elasticity restore；And stimulation of the inflammatory reaction to the surface of a wound can be also reduced, it is right
Skin has the function of minimally invasive analgesia, anti-inflammatory.And any medicine components or chemical reagent are not added in above-mentioned composition, no surface of a wound
Risk is stimulated, it is highly-safe.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.Below in conjunction with embodiment, the present invention will be described in detail.
As described in background technique, facial mask in the prior art is difficult to take into account moisture retention and permeability.In order to solve
Above-mentioned technical problem, the present invention provides a kind of beautifying skin remediation compositions.
In a kind of typical embodiment of the application, a kind of beautifying skin remediation composition, the composition packet are provided
Include natural polysaccharide and native protein, natural polysaccharide include molecular weight be the high molecular weight polysaccharide of 200K~800K Da, molecular weight is
The middle-molecular-weihydroxyethyl polysaccharide and molecular weight of 10K~100KDa is the Low-molecular-weight polysaccharide of 200~9500Da.
The beautifying skin remediation composition of the application is using natural polysaccharide, albumen as Main Components, by each molecular weight section
It is compound, " exogenous cells assign repair system living " can be formed, not only can provide wet physical barriers reduces minimally invasive skin after doctor's beauty
The cough and sensibility of skin, it is possible to provide sterile, moisturizing skin histology repairing environment, and it is permeable to different skin histologies
Inducing skin cells growth promotes collagen synthesis and collagenous fibres maturation, activation skin itself to repair function, to reach skin
The effect of compact, the elastic recovery of skin；And stimulation of the inflammatory reaction to the surface of a wound can be also reduced, there is minimally invasive analgesia, anti-inflammatory to skin
Effect.And any medicine components or chemical reagent are not added in above-mentioned composition, the no surface of a wound stimulates risk, highly-safe.Tool
Body:
Above-mentioned high molecular weight polysaccharide can form one layer of ventilative film in skin surface, and it is outer to play long-acting wet and barrier
Come bacterium, dust, ultraviolet light intrusion effect, and then after protecting doctor's beauty relatively fragile skin histology from secondary infringement；
Middle-molecular-weihydroxyethyl polysaccharide can gradually infiltrate into epidermis, dermis, improve skin microenvironment, and then reach permanent moisturizing, compact
The effect of skin；Low-molecular-weight polysaccharide can penetrate into skin corium, and inducing skin cells growth promotes collagen synthesis and collagen fine
Dimension is mature, to have the function that skin-tightening, elasticity recovery and the minimally invasive analgesia of skin, anti-inflammatory, can increase skin elasticity, delay skin
Skin aging.
In a preferred embodiment of the present application, the molecular weight of above-mentioned high molecular weight polysaccharide is 200K~500K Da, excellent
The molecular weight for choosing molecular weight polysaccharide is 10K~80K Da, and preferably the molecular weight of Low-molecular-weight polysaccharide is 200~8000Da.It is logical
It crosses to the further preferred of the molecular weight of above-mentioned each component, is not fully exerted so that each component acts on accordingly.
In addition, preferably above-mentioned native protein is small molecule native protein, further in order to make protein be easier to be absorbed
It is preferred that the molecular weight of the small molecule native protein is 200~10000Da；Preferably 200~5000Da.
In the application another kind preferred embodiment, in parts by weight, in above-mentioned composition, high molecular weight polysaccharide 10
~40 parts, middle-molecular-weihydroxyethyl polysaccharide is 5~20 parts, and Low-molecular-weight polysaccharide is 5~30 parts, and small-molecular-weight native protein is 5~30 parts.
The content of the composition of above-mentioned composition, high molecular weight polysaccharide is slightly more, and providing for skin histology more fragile after doctor's beauty more has
The wet physical barriers of effect alleviate stimulation, avoid secondary damage；Middle-molecular-weihydroxyethyl polysaccharide forms more mild skin microenvironment；
Boy's molecular weight polysaccharide is fully infiltrated into skin corium, can effectively activate the activity of skin epidermis, dermis layer tissue cell, inducing cell
Regeneration and Repair promotes skin quality.
Further, in parts by weight, preferably in above-mentioned composition, high molecular weight polysaccharide is 10~30 parts, middle-molecular-weihydroxyethyl
Polysaccharide is 5~15 parts, and Low-molecular-weight polysaccharide is 10~20 parts, and small-molecular-weight native protein is 10~30 parts.
Applied to the application natural polysaccharide can there are many, in order to take into account moisture retention and infiltration with alap cost
Property, preferably above-mentioned natural polysaccharide is selected from the one or more of the group of hyaluronic acid, sodium alginate, water soluble chitosan composition.It is excellent
Selection of land, above-mentioned water soluble chitosan be selected from carboxymethyl chitosan, carboxymethyl chitin, hydroxypropyl chitosan, Hydroxypropyl chitosan,
Hydroxyethyl chitosan, ethoxyl chitin, hydroxyl butyl chitosan, hydroxyl butyl chitin, chitosan quaternary ammonium salt, chitosan lactic acid
One of salt, glutamate, group of sulfated chitosan composition are a variety of.Above-mentioned each substance selects suitable molecule
Amount is combined and realizes above-mentioned technical effect.
In addition, above-mentioned native protein can also can be used in the albumen of skin being selected from the prior art, preferably
Above-mentioned native protein in the group that collagen, gelatin, elastin, fibroin albumen and its respective derivative form one
Kind is a variety of.The repairing effect of above-mentioned various albumen is ideal.
In another typical embodiment of the application, a kind of facial mask is provided, including for beautifying skin reparation
Composition, the composition that the composition is any of the above-described kind.Above-mentioned facial mask can form " exogenous cells assign repair system living ", no
Only can provide wet physical barriers reduces the cough and sensibility of minimally invasive skin after doctor's beauty, it is possible to provide sterile, moisturizing skin
Skin tissue repairing environment, and be permeable to different skin histology inducing skin cells growths, promote collagen synthesis and glue
Fibrinogen is mature, activation skin itself repairs function, to have the function that skin-tightening, elasticity restore；And it can also reduce inflammatory
The stimulation to the surface of a wound is reacted, has the function of minimally invasive analgesia, anti-inflammatory to skin.
Above-mentioned facial mask can be prepared into liquid or solation, the application in a manner of coating, for ease of use, preferably on
Stating facial mask further includes mask sheet, and composition is supported on mask sheet.Such as it is natural polysaccharide each in composition and native protein is sharp
After mixing with purified water dissolution, mask sheet dipping can be formed into above-mentioned facial mask wherein.
Below in conjunction with specific embodiment, present invention is further described in detail, these embodiments should not be understood as limitation originally
Invent range claimed.
Following molecular weight is weight average molecular weight.
Embodiment 1
The beautifying skin remediation composition of embodiment 1 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 2
The beautifying skin remediation composition of embodiment 2 includes: 5 parts of high molecular weight sodium hyaluronate (250K Da), macromolecule
It measures 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 3
The beautifying skin remediation composition of embodiment 3 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 5 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight collagen polypeptide (2000Da), small molecule
Measure elastic 10 parts of collagen polypeptide (3000Da).
Embodiment 4
The beautifying skin remediation composition of embodiment 4 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), in point
Son amount 10 parts of Sodium Hyaluronate (80K Da), 5 parts of middle-molecular-weihydroxyethyl sodium alginate (80K Da), small-molecular-weight Sodium Hyaluronate
10 parts of (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), 15 parts, small point of small-molecular-weight collagen polypeptide (2000Da)
Son measures elastic 15 parts of collagen polypeptide (3000Da).
Embodiment 5
The beautifying skin remediation composition of embodiment 5 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 5 parts of middle-molecular-weihydroxyethyl sodium alginate (80K Da), small-molecular-weight Sodium Hyaluronate
10 parts of (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), 5 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 6
The beautifying skin remediation composition of embodiment 6 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), small-molecular-weight Sodium Hyaluronate
10 parts of (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), 5 parts, small point of small-molecular-weight collagen polypeptide (2000Da)
Son measures elastic 5 parts of collagen polypeptide (3000Da).
Embodiment 7
The beautifying skin remediation composition of embodiment 7 includes: 20 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 20 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), 10 parts of small-molecular-weight collagen polypeptide (2000Da), small-molecular-weight bullet
10 parts of property collagen polypeptide (3000Da).
Embodiment 8
The beautifying skin remediation composition of embodiment 8 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 10 parts of sodium alginate (200K Da), 5 parts of middle-molecular-weihydroxyethyl sodium alginate (80K Da), small-molecular-weight Sodium Hyaluronate
10 parts of (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), 10 parts, small point of small-molecular-weight collagen polypeptide (2000Da)
Son measures elastic 10 parts of collagen polypeptide (3000Da).
Embodiment 9
The beautifying skin remediation composition of embodiment 9 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 10 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 10 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight glue
Former 10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 10
The beautifying skin remediation composition of embodiment 10 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 10 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 15 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 11
The beautifying skin remediation composition of embodiment 11 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da).
Embodiment 12
The beautifying skin remediation composition of embodiment 12 includes: 15 parts of high molecular weight sodium hyaluronate (800K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 15 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 13
The beautifying skin remediation composition of embodiment 13 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (10K Da), middle-molecular-weihydroxyethyl sodium alginate (10K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 14
The beautifying skin remediation composition of embodiment 14 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (100K Da), middle-molecular-weihydroxyethyl sodium alginate
5 parts of (100K Da), 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small molecule
It measures 10 parts of collagen polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 15
The beautifying skin remediation composition of embodiment 15 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (200Da), 10 parts of small-molecular-weight chitosan oligosaccharide (200Da), small-molecular-weight collagen egg
White 10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 16
The beautifying skin remediation composition of embodiment 16 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (9500Da), 10 parts of small-molecular-weight chitosan oligosaccharide (9000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 17
The beautifying skin remediation composition of embodiment 17 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (200Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 18
The beautifying skin remediation composition of embodiment 18 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (100K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 15 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 15 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (10000Da).
Embodiment 19
The beautifying skin remediation composition of embodiment 19 includes: 20 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 10 parts of sodium alginate (100K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight chitosan oligosaccharide (2000Da), small-molecular-weight collagen
10 parts of polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Embodiment 20
The beautifying skin remediation composition of embodiment 1 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 3 parts of small-molecular-weight Sodium Hyaluronate (5000Da), 10 parts of small-molecular-weight collagen polypeptide (2000Da), small molecule
Measure elastic 10 parts of collagen polypeptide (3000Da).
Comparative example 1
The beautifying skin remediation composition of comparative example 1 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle-molecular-weihydroxyethyl sodium alginate (80K
Da) 5 parts, 10 parts of small-molecular-weight collagen polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
Comparative example 2
The beautifying skin remediation composition of comparative example 2 includes: 15 parts of high molecular weight sodium hyaluronate (250K Da), high score
Son amount 5 parts of sodium alginate (200K Da), 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), small-molecular-weight chitosan oligosaccharide
10 parts of (2000Da), 10 parts of small-molecular-weight collagen polypeptide (2000Da), small-molecular-weight elasticity collagen polypeptide (3000Da) 10
Part.
Comparative example 3
The beautifying skin remediation composition of comparative example 3 includes: 10 parts of middle-molecular-weihydroxyethyl Sodium Hyaluronate (80K Da), middle molecule
It measures 5 parts of sodium alginate (80K Da), 10 parts of small-molecular-weight Sodium Hyaluronate (5000Da), small-molecular-weight chitosan oligosaccharide (2000Da) 10
Part, 10 parts of small-molecular-weight collagen polypeptide (2000Da), 10 parts of small-molecular-weight elasticity collagen polypeptide (3000Da).
The effect of to prove this product, has carried out following tests:
1. security test: recruiting 200 volunteers, one group of every 10 people respectively tests embodiment 1-20.Every
Subject is tested with doing control on the inside of left and right arm: each deposited product of the present invention 15min on the inside of left arm, deposited pair on the inside of right arm
1 product 15min of ratio, twice daily, record for 24 hours, the dermoreaction situation of 72h.
The result shows that: apply product of the present invention for 24 hours, after 72h, have no the allergic phenomenas such as rubefaction or erythema, it was demonstrated that this hair
Bright product has good human safety.
2. both effectiveness test:
Recruit 345 30-55 years old volunteers, one group of every 15 people.The product prepared to above-described embodiment and comparative example connects
It is continuous 30 days on probation, comparative analysis the said goods the effect of property, including moisture of skin (detecting instrument: Corneometer CM825),
Skin elasticity (Cutometer MPA580), moisture retention (detecting instrument: Tewameter TM300), skin shine (MPA9-
GL200), cutaneous sensibility (including shouting pain, itch, erythema etc.).Skin, which improves situation result, see the table below 1.
Table 1
It can be seen from the above description that the above embodiments of the present invention realized the following chievements:
Using natural polysaccharide, albumen as Main Components, being compounded to form with different molecular weight not only can moisturizing but also can be deeply true
" exogenous cells assign living repair system " of cortex induced skin regeneration, not drug containing, preservative or other chemical substances,
Nonirritant or sensitization, it is highly-safe.
Material in composition is natural degradable biomaterial, mild non-stimulated, no sensitization, cytotoxicity etc.,
Not only can provide moisturizing, protection barrier action, avoid environmental stimuli from damaging, but also can induce epidermis, skin corium cell Proliferation
Secretion assigns inducing endogenous in-situ immobilization living by exogenous cells, and reaching improves skin quality from inside to outside, consolidates and cure U.S. effect
The effect of.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of beautifying skin remediation composition, which is characterized in that the composition includes:
Natural polysaccharide, the natural polysaccharide include that molecular weight is the high molecular weight polysaccharide of 200K~800K Da, molecular weight 10K
The middle-molecular-weihydroxyethyl polysaccharide and molecular weight of~100KDa is the Low-molecular-weight polysaccharide of 200~9500Da；
Native protein.
2. composition according to claim 1, which is characterized in that the molecular weight of the high molecular weight polysaccharide be 200K~
500K Da, the molecular weight of the preferably described middle-molecular-weihydroxyethyl polysaccharide are 10K~80K Da, the molecule of the preferably described Low-molecular-weight polysaccharide
Amount is 200~8000Da.
3. composition according to claim 1, which is characterized in that the native protein is small molecule native protein, preferably
The molecular weight of the small molecule native protein is 200~10000Da；Preferably 200~5000Da.
4. composition according to claim 1, which is characterized in that in parts by weight, in the composition, the macromolecule
Measuring polysaccharide is 10~40 parts, and the middle-molecular-weihydroxyethyl polysaccharide is 5~20 parts, and the Low-molecular-weight polysaccharide is 5~30 parts, described natural
Albumen is 5~30 parts.
5. composition according to claim 4, which is characterized in that in parts by weight, in the composition, the macromolecule
Measuring polysaccharide is 10~30 parts, and the middle-molecular-weihydroxyethyl polysaccharide is 5~15 parts, and the Low-molecular-weight polysaccharide is 10~20 parts, the day
Right albumen is 10~30 parts.
6. composition according to claim 1, which is characterized in that the natural polysaccharide be selected from hyaluronic acid, sodium alginate,
Water soluble chitosan composition group it is one or more.
7. composition according to claim 6, which is characterized in that the water soluble chitosan be selected from carboxymethyl chitosan,
Carboxymethyl chitin, hydroxypropyl chitosan, Hydroxypropyl chitosan, hydroxyethyl chitosan, ethoxyl chitin, hydroxyl butyl shell are poly-
The group of sugar, hydroxyl butyl chitin, chitosan quaternary ammonium salt, chitosan lactate, glutamate, sulfated chitosan composition
One of or it is a variety of.
8. composition according to claim 1, which is characterized in that the native protein is selected from collagen, gelatin, elastic force
One of group of albumen, fibroin albumen and its respective derivative composition is a variety of.
9. a kind of facial mask, including the composition for beautifying skin reparation, which is characterized in that the composition is claim 1
To composition described in any one of 8.
10. facial mask according to claim 9, which is characterized in that the facial mask further includes mask sheet, the composition load
On the mask sheet.
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| CN113730283A (en) * | 2021-10-14 | 2021-12-03 | 扬州日兴生物科技股份有限公司 | Natural moisturizing and bacteriostatic facial mask containing compound functional chitosan |
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