CN108421082A - The preparation method of graphene oxide wound dressing with antibacterial anti-scar double action - Google Patents

The preparation method of graphene oxide wound dressing with antibacterial anti-scar double action Download PDF

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Publication number
CN108421082A
CN108421082A CN201810369012.XA CN201810369012A CN108421082A CN 108421082 A CN108421082 A CN 108421082A CN 201810369012 A CN201810369012 A CN 201810369012A CN 108421082 A CN108421082 A CN 108421082A
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Prior art keywords
graphene oxide
wound dressing
scar
double action
auxiliary material
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CN201810369012.XA
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Chinese (zh)
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闫金银
孟英
胡万宁
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0085—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents

Abstract

The present invention relates to a kind of preparation methods of the graphene oxide wound dressing with antibacterial anti-scar double action.Using graphene oxide as raw material, by sonic oscillation dispersion, be separated by solid-liquid separation, three basic programs of drug loading and obtain product.Graphene oxide dressing thickness prepared by the present invention is controllable, and large specific surface area, adsorptivity is excellent, and intensity and flexibility are good, nontoxic sterile, and antibacterial, anti-cicatrization is non-stimulated to human body, with skin wound no adhesion, environmental protection；Preparation method is simple, easy to operate, and production cost is relatively low.Wound dressing prepared by the present invention can be widely used for the wound healing of conventional and minimally invasive plastic operation and anti-cicatrization, the healing of the surface of a wound such as skin burn, contusion and anti-cicatrization.

Description

The preparation method of graphene oxide wound dressing with antibacterial anti-scar double action
Technical field
The present invention relates to compress material outside bio-medical, specifically a kind of graphite oxide with antibacterial anti-scar double action The preparation method of alkene wound dressing.
Background technology
Graphene（Graphene）A kind of new material for the individual layer laminated structure being made of carbon atom, by carbon atom with Sp2 hybridized orbits form the flat film that hexangle type is in honeycomb lattice, and only there are one the two-dimensional materials of carbon atom thickness.Graphite Alkene can be fabricated to the macroscopically material in paper-like, have the characteristics that high intensity, light weight, absorption property are excellent.Tradition is applied with material Material, such as gauze, bandage, oily yarn, are still widely used in clinic, have water imbibition and heat insulating ability excellent heat resistance and alkali resistance good The features such as.But after absorbing wound exudate due to traditional auxiliary material, often can due to secretion oozes out contaminated wound, and remove external application material It is easy adhesion wound when material, promotes wound cicatrization.In order to solve compress material adhesion wound, easy infection, easy shape outside tradition At scar, insulating power difference and hemostasis, it is hemagglutinin bad the shortcomings of, people improve this kind of outer compress material using various methods Performance, such as dipping, coating and chemically or physically method of modifying, but effect is all undesirable.Carbon-based material is because of good adsorptivity Can, nontoxic sterile, heat resistance the features such as by people's extensive concern, graphene is as a kind of since its is excellent of carbon-based material Characteristic is considered having wide practical use in this respect.
CN201410162366.9 discloses a kind of graphene wound dressing, is easily grown carefully with solving existing wound dressing Using effect problem caused by the problems such as bacterium, easy adhesion.The graphene wound dressing, not in its area load antibacterial or anti-scar Therefore the biotic factor or drug of trace can only play the antibacterial effect of antibacterial surface by the physicochemical property of itself to wound, Antibacterial effect is limited, and cannot meet the needs of inhibiting bacterial wound breeding to grow and inhibiting wound scar formation simultaneously.
Invention content
The graphene oxide wound with antibacterial anti-scar double action that the technical problem to be solved in the present invention is to provide a kind of The preparation method of mouth dressing, wound dressing thickness prepared by this method is controllable, can carry antibacterial anti-scarring drug, specific surface area Greatly, pore structure is abundant, and to body fluid strong adsorption, intensity is high, and flexibility is good, with skin wound no adhesion, can be recycled；It should Method operating procedure is simple, and production cost is low, is suitable for large-scale production.
The present invention solve its technical problem the technical solution adopted is that：
A kind of preparation method of the graphene oxide wound dressing with antibacterial anti-scar double action, includes the following steps：
(1) sonic oscillation disperses；
Using graphene oxide as raw material, by the quality of graphene oxide: the quality of auxiliary material: the ratio between volume of solvent is 1g: 0~1g : graphene oxide and auxiliary material are added in solvent by the ratio of 10~20ml, after stirring evenly, sonic oscillation dispersion 30~ 120 minutes, obtain the dispersion mixing liquid of graphene oxide and auxiliary material；
(2) it is separated by solid-liquid separation；
By the dispersion mixing liquid of graphene oxide and auxiliary material made from step (1), it is separated by solid-liquid separation with filter membrane vacuum filtration instrument, Separating liquid and solid residue are collected respectively；
(3) drug loading；
Even application nano-ZnO or spraying vitamin A acid on the solid residue that step (2) is collected, obtaining load has drug Then load is had the solid residue of drug by solid residue, 0.5~2 hour dry at being 40~80 DEG C in temperature, is obtained To the graphene oxide wound dressing of paper-like.
Using the present invention of above-mentioned technical proposal, compared with prior art, advantageous effect is：
(1) graphene oxide wound dressing is nontoxic sterile, while carrying anti-biotic material nano-ZnO and anti-scarring drug vitamin A acid； Nonirritant to human body, absorption property is strong, and adhesion will not be caused with skin wound, can be obviously promoted skin wound healing, reduces Scar generates.
(2) thickness of graphene oxide wound dressing is between 0.5~3mm, aperture be mainly distributed on 6~50nm it Between, large specific surface area to 100m2/g or more has good pore size distribution$ and absorption property；The fiber being evenly distributed simultaneously Shape auxiliary material has good mechanical property, can effectively improve its mechanical strength and flexibility.
(3) sonic oscillation dispersion and separation of solid and liquid and drying etc. are used, high-temperature process is not necessarily to, energy consumption is low.
(4) be not necessarily to catalyst, to the solvent in production process can also recycling, without " three wastes " discharge, belong to cycle Economy, can reduce production cost and.
(5) simple for process, easy to operate, production equipment is few, easy to utilize to further reduce the cost, and is suitable for Large-scale production.
Further, preferred embodiment of the present invention is：
The solvent is absolute ethyl alcohol or deionized water.
The auxiliary material is carbon fiber or carbon nano-fiber.
The filter membrane of the filter membrane vacuum filtration instrument is teflon membrane filter.
Specific implementation mode
The present invention is described in detail with reference to embodiment.
The preparation method of the graphene oxide wound dressing with antibacterial anti-scar double action described in the present embodiment, with Graphene oxide as raw material, by sonic oscillation dispersion, be separated by solid-liquid separation, drug loading and obtain product, be as follows：
(1) sonic oscillation disperses：
Using graphene oxide as raw material, according to the quality (g) of graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent The ratio between be 1: 0.8: 15 ratio, graphene oxide and auxiliary material are added in solvent, after stirring evenly, in the output of ultrasonic wave Power is to carry out sonic oscillation under 150~500W and disperse 30~120 minutes, just obtain the dispersion of graphene oxide and auxiliary material Mixed liquor；Wherein：Solvent is absolute ethyl alcohol；Auxiliary material is carbon nano-fiber.
(2) it is separated by solid-liquid separation：
After the completion of (1) step, by the dispersion mixing liquid of graphene oxide made from (1) step and auxiliary material, using 100~ Vacuum filtration instrument of the 300ml with filter membrane is separated by solid-liquid separation, and collects separating liquid (i.e. solvent) and solid residue respectively；
Wherein：Filter membrane is nylon leaching film or teflon membrane filter.
(3) drug loading：
After the completion of (2) step, medicament (nano-ZnO) and sprinkling are uniformly sprayed on the solid residue that (2) step is collected Drug (vitamin A acid), and obtaining load has the solid residue of drug, then load is had to the solid residue of drug, in temperature Degree is 0.5~2 hour dry at 40~80 DEG C, just obtains bio-medical graphene oxide paper.
The foregoing is merely preferably feasible embodiments of the invention, not thereby limit to the interest field of the present invention, Equivalence changes made by all contents with description of the invention are both contained within the interest field of the present invention.

Claims (4)

1. a kind of preparation method of the graphene oxide wound dressing with antibacterial anti-scar double action, which is characterized in that packet Include following step：
(1) sonic oscillation disperses；
Using graphene oxide as raw material, by the quality of graphene oxide: the quality of auxiliary material: the ratio between volume of solvent is 1g: 0~1g : graphene oxide and auxiliary material are added in solvent by the ratio of 10~20ml, after stirring evenly, sonic oscillation dispersion 30~ 120 minutes, obtain the dispersion mixing liquid of graphene oxide and auxiliary material；
(2) it is separated by solid-liquid separation；
By the dispersion mixing liquid of graphene oxide and auxiliary material made from step (1), it is separated by solid-liquid separation with filter membrane vacuum filtration instrument, Separating liquid and solid residue are collected respectively；
(3) drug loading；
Even application nano-ZnO or spraying vitamin A acid on the solid residue that step (2) is collected, obtaining load has drug Then load is had the solid residue of drug by solid residue, 0.5~2 hour dry at being 40~80 DEG C in temperature, is obtained To the graphene oxide wound dressing of paper-like.
2. according to the preparation side of the graphene oxide wound dressing with antibacterial anti-scar double action described in claim 1 Method, it is characterised in that：The solvent is absolute ethyl alcohol or deionized water.
3. according to the preparation side of the graphene oxide wound dressing with antibacterial anti-scar double action described in claim 1 Method, it is characterised in that：The auxiliary material is carbon fiber or carbon nano-fiber.
4. according to the preparation side of the graphene oxide wound dressing with antibacterial anti-scar double action described in claim 1 Method, it is characterised in that：The filter membrane of the filter membrane vacuum filtration instrument is teflon membrane filter.
CN201810369012.XA 2018-04-23 2018-04-23 The preparation method of graphene oxide wound dressing with antibacterial anti-scar double action Withdrawn CN108421082A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109395152A (en) * 2018-09-21 2019-03-01 南通强生石墨烯科技有限公司 A kind of compound hydrocolloid medical dressing of graphene and preparation method thereof
CN113384738A (en) * 2021-06-10 2021-09-14 山东良福制药有限公司 Preparation method of tretinoin dressing for promoting wound healing

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109395152A (en) * 2018-09-21 2019-03-01 南通强生石墨烯科技有限公司 A kind of compound hydrocolloid medical dressing of graphene and preparation method thereof
CN113384738A (en) * 2021-06-10 2021-09-14 山东良福制药有限公司 Preparation method of tretinoin dressing for promoting wound healing

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