CN102926272B - Process for preparing biomedical graphene oxide paper - Google Patents
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- CN102926272B CN102926272B CN201210434776.5A CN201210434776A CN102926272B CN 102926272 B CN102926272 B CN 102926272B CN 201210434776 A CN201210434776 A CN 201210434776A CN 102926272 B CN102926272 B CN 102926272B
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 229910021389 graphene Inorganic materials 0.000 title claims abstract description 56
- 238000004519 manufacturing process Methods 0.000 title abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 238000000926 separation method Methods 0.000 claims abstract description 18
- 239000006185 dispersion Substances 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 238000011068 loading method Methods 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000007787 solid Substances 0.000 claims description 30
- 239000002904 solvent Substances 0.000 claims description 22
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 230000010355 oscillation Effects 0.000 claims description 8
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical group II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 7
- 238000003828 vacuum filtration Methods 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229920000153 Povidone-iodine Polymers 0.000 claims description 6
- 229960001621 povidone-iodine Drugs 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- LLYXJBROWQDVMI-UHFFFAOYSA-N 2-chloro-4-nitrotoluene Chemical compound CC1=CC=C([N+]([O-])=O)C=C1Cl LLYXJBROWQDVMI-UHFFFAOYSA-N 0.000 claims description 5
- 239000004809 Teflon Substances 0.000 claims description 5
- 229920006362 Teflon® Polymers 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 229920000049 Carbon (fiber) Polymers 0.000 claims description 4
- 239000004677 Nylon Substances 0.000 claims description 4
- 239000004917 carbon fiber Substances 0.000 claims description 4
- 229960000479 ceftriaxone sodium Drugs 0.000 claims description 4
- FDRNWTJTHBSPMW-GNXCPKRQSA-L disodium;(6r,7r)-7-[[(2e)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-6-oxido-5-oxo-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound [Na+].[Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)/C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C([O-])=NN1C FDRNWTJTHBSPMW-GNXCPKRQSA-L 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 229940098465 tincture Drugs 0.000 claims description 4
- 239000009306 yunnan baiyao Substances 0.000 claims description 4
- 239000002134 carbon nanofiber Substances 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 206010072170 Skin wound Diseases 0.000 abstract description 6
- 239000011148 porous material Substances 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 abstract description 3
- 230000029663 wound healing Effects 0.000 abstract description 3
- 239000003990 capacitor Substances 0.000 abstract description 2
- 239000007772 electrode material Substances 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract description 2
- 238000001179 sorption measurement Methods 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 7
- 229910002804 graphite Inorganic materials 0.000 description 7
- 239000010439 graphite Substances 0.000 description 7
- 206010052428 Wound Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 238000004064 recycling Methods 0.000 description 4
- 229920002749 Bacterial cellulose Polymers 0.000 description 3
- -1 as dipping Substances 0.000 description 3
- 239000005016 bacterial cellulose Substances 0.000 description 3
- 238000011031 large-scale manufacturing process Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 239000003575 carbonaceous material Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
The invention discloses a process for preparing biomedical graphene oxide paper and belongs to the field of biomedical materials. According to the process, a graphene oxide bought from market serves as a raw material, and a product is obtained through ultrasonic oscillating dispersion, solid-liquid separation and drug loading. The biomedical graphene oxide paper prepared by the process has the advantages of being controllable in thickness, large in specific surface area, abundant in pore structure, good in adsorptivity, strength and flexibility, free from toxicity and bacteria, free from irritation on human bodies and cohesiveness on skin wounds, environment-friendly and the like. The process is simple in technology, convenient to operate, low in production cost, beneficial to popularization and application and the like. The product prepared by the process can be widely applied to medical external application materials which are used for treating skin wounds (such as burns), promoting wound healing and the like, and the product can also be used for electrode materials of super-capacitors and environmental protection materials for adsorption, purification and the like.
Description
Technical field
The invention belongs to biology medical material technical field, be specifically related to the preparation method of outer compress material bio-medical graphene oxide paper.
Background technology
Graphene (Graphene) refers to the graphite of carbon (C) atomic layer level thickness, by sp between carbon-to-carbon
2covalent linkage is hexagonal network aspect, is considered to the basic structural unit of fullerene, CNT and graphite.Graphene paper is by the material macroscopically in paper-like of Graphene self assembly.There is the features such as high strength, quality is light, absorption property is excellent.The outer compress material of tradition, comprises gauze, bandage etc., although they have water imbibition and heat insulating ability is excellent, heat resistance and feature, the still extensive use in various types of wound so far such as alkali resistance is better.But after their absorption wound exudate, often can cause wound infection because secretion oozes out pollution, and easy adhesion wound etc. when removing outer compress material.In order to solve the outer compress material adhesion wound of tradition, not every bacterium, insulating power difference and stop blooding, the hemagglutinin shortcoming such as bad, people adopt various method to improve the performance of this kind of outer compress material, as dipping, coating and chemistry or physical modification method, but effect is all undesirable.Carbon-based material is because the feature such as good absorption property, nontoxic aseptic, heat resistance is subject to people's extensive concern, and Graphene is considered to have wide practical use in this respect as a kind of characteristic due to its excellence of carbon-based material.
The preparation method of existing medical graphite alkene material, it is the patent of " bacterial cellulose/graphene composite material and preparation method thereof " of 201110063663.4 as application number, disclosed method is: first prepare moistening bacterial cellulose product, again Graphene pulverized, stir and make graphene dispersing solution, then by graphene dispersing solution and bacteria cellulose mixing, then bacterial cellulose/graphene composite material is prepared by Separation of Solid and Liquid.The major defect of the method is: process conditions are complicated, consuming time long, and single with the types of drugs of Graphene compound, are not suitable with the requirement of large-scale production.And for example application number is the patent of " method of using expansion graphite as wound auxiliary material " of 95115437.0, disclosed method is: first prepare expanded graphite pulvis, hybrid medicine in graphite pulvis again, finally applies this mixing powder and is pressed into band-type product at hospital gauze or carbon fiber surface.The major defect of the method is: be only only apply to cause drug powder easily to come off on surface to cause medical value to reduce with expanded graphite based on normal gauze, easily bond with skin wound and cause patient's misery, that fails to make full use of Graphene enriches pore structure and the advantage such as high strength, pliability.
Summary of the invention
The object of the invention is to the deficiency for existing bio-medical grapheme material, a kind of preparation method of bio-medical graphene oxide paper is provided, there is thickness controlled, specific area is large, pore structure is abundant, strong to body fluid adsorptivity, intensity is high, pliability good and skin wound no adhesion, the characteristic such as can be recycled; It is simple, easy to operate that the method has technique, and production cost is low, be suitable for the advantages such as large-scale production.
The technical scheme realizing the object of the invention is: a kind of preparation method of bio-medical graphene oxide paper, using commercial graphene oxide as raw material, through sonic oscillation dispersion, Separation of Solid and Liquid, drug loading and obtain product.The concrete steps of described method are as follows:
(1) sonic oscillation dispersion
With commercial graphene oxide for raw material, quality (g) according to graphene oxide: the quality (g) of auxiliary material: the ratio of the volume (ml) of solvent is the ratio of 1: 0 ~ 1: 20 ~ 100, graphene oxide and auxiliary material are joined in solvent, after stirring, under hyperacoustic power output is 150 ~ 500W, carry out sonic oscillation dispersion 30 ~ 120 minutes, just obtain the dispersion mixed liquor of graphene oxide and auxiliary material.
Wherein: described solvent is absolute ethyl alcohol or deionized water etc.;
Described auxiliary material is CNT or activated carbon fiber or carbon fiber or carbon nano-fiber etc.
(2) Separation of Solid and Liquid
After (1) step completes, the graphene oxide that (1) step is obtained and the dispersion mixed liquor of auxiliary material, adopt 100 ~ 300ml to be with the vacuum filtration instrument of filter membrane to carry out Separation of Solid and Liquid, collect parting liquid (i.e. solvent) and solid residue respectively.Recycling is carried out to the parting liquid (i.e. solvent) collected.
Wherein: the nylon leaching film of described filter membrane or teflon membrane filter etc.
(3) drug loading
After (2) step completes, the solid residue that (2) step is collected uniformly sprays medicament (i.e. Povidone-Iodine Solution or PVP-I or the tincture of iodine) or spraying medicine (i.e. Yunnan Baiyao or ceftriaxone sodium) and obtains the solid residue that load has medicine, then load there is the solid residue of medicine, at temperature is 40 ~ 80 DEG C, drying 0.5 ~ 2 hour, just obtains bio-medical graphene oxide paper.
Wherein: described medicament is povidone-iodine or Povidone-Iodine Solution or the tincture of iodine, and medicine is Yunnan Baiyao or or ceftriaxone sodium.
After the present invention adopts technique scheme, there is following effect:
(1) the inventive method prepare bio-medical graphene oxide paper nontoxic aseptic, to human body nonirritant, absorption property, strong and skin wound can not cause adhesion to be conducive to skin wound healing.
(2) the inventive method prepares the thickness of bio-medical graphene oxide paper between 0.5 ~ 3mm, and aperture is mainly distributed between 6 ~ 50nm, and specific area arrives 100m greatly
2/ more than g, has good pore size distribution$ and absorption property.The fibrous auxiliary material energy well mechanical property be simultaneously evenly distributed, can effectively improve its mechanical strength and pliability.
(3) the inventive method adopts sonic oscillation dispersion and Separation of Solid and Liquid and drying etc., and without the need to high-temperature process, energy consumption is low.
(4) the inventive method is without the need to catalyst, can also recycling to the solvent in production process, and without " three wastes " discharge, belong to recycling economy, this can reduce production cost, is conducive to environmental protection again.
(5) present invention process is simple, and easy to operate, production equipment is few, thus reduces costs further, easy to utilize, is suitable for large-scale production.
The bio-medical graphene oxide paper adopting the inventive method to prepare, can be widely used in treatment skin trauma (as burn) and promote that the medical external dressing material of wound healing etc. also can be used for environment conscious material and the electrode material for super capacitor such as absorption, purification.
Accompanying drawing explanation
Fig. 1 is the scanning electron microscope (SEM) photograph of the present embodiment 1 bio-medical graphene oxide paper,
In figure: 1 is carrying medicament, 2 is graphene oxide lamella, and 3 is activated carbon fiber.
Detailed description of the invention
Below in conjunction with detailed description of the invention, further illustrate the present invention.
Embodiment 1
The concrete steps of a kind of bio-medical graphene oxide paper preparation method are as follows:
(1) sonic oscillation dispersion
Quality (g) according to graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent is than the ratio being 1: 0.5: 50, graphene oxide and auxiliary material are put into solvent, after stirring, under ultrasonic output frequency is 500W, carry out sonic oscillation and disperse 60 minutes, obtain the dispersion mixed liquor of graphene oxide and auxiliary material.
Wherein: described auxiliary material is activated carbon fiber;
Described solvent is absolute ethyl alcohol.
(2) Separation of Solid and Liquid
After (1) step completes, 200ml is adopted to be with the vacuum filtration instrument of teflon membrane filter, the graphene oxide prepare (1) step and the dispersion mixed liquor of auxiliary material activated carbon fiber carry out Separation of Solid and Liquid, collect parting liquid (i.e. anhydrous ethanol solvent) and solid residue respectively, recycling is carried out to the parting liquid (i.e. anhydrous ethanol solvent) collected.
(3) drug loading
After (2) step completes, uniform spraying medicine Yunnan Baiyao on the surface of the solid residue of (2) step collection, just obtain the solid residue that load has medicine, then load there is the solid residue of medicine, under temperature 60 C, drying 60 minutes, just prepares bio-medical graphene oxide paper.
Embodiment 2
Preparation method is with embodiment 1 for one bio-medical graphene oxide paper, wherein:
In (1) step, the quality (g) of graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent is than being 1: 1: 100, and ultrasonic frequency is 300W, and the ultrasonic Separation time is 120 minutes.
Wherein: described auxiliary material is CNT;
Described solvent is deionized water.
In (2) step, 300ml is adopted to be with the vacuum filtration instrument of nylon leaching film that the mixed liquor that (1) step is prepared is carried out Separation of Solid and Liquid.
In (3) step, the surface of the solid residue of (2) step collection uniformly sprays the medicament tincture of iodine, just obtains the solid residue that load has medicine, wherein: drying 120 minutes at temperature is 80 DEG C.
Embodiment 3
Preparation method is with embodiment 1 for one bio-medical graphene oxide paper, wherein:
In (1) step, the quality (g) of graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent is than being 1: 0: 20, and ultrasonic frequency is 150W, and the ultrasonic Separation time is 80 minutes.
Wherein: described auxiliary material is CNT;
Described solvent is deionized water.
In (2) step, the graphene oxide adopting 100ml to be with the vacuum filtration instrument of teflon membrane filter (1) step to be prepared and the mixed liquor of auxiliary material dispersion carry out Separation of Solid and Liquid.
In (3) step, the surface of the solid residue of (2) step collection uniformly sprays medicament Povidone-Iodine Solution, wherein: drying 30 minutes at temperature is 100 DEG C.
Embodiment 4
Preparation method is with embodiment 1 for one bio-medical graphene oxide paper, wherein:
In (1) step, the quality (g) of graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent is than being 1: 0.2: 20, and ultrasonic frequency is 300W, and the ultrasonic Separation time is 30 minutes.
Wherein: described auxiliary material is carbon nano-fiber;
Described solvent is deionized water.
In (2) step, 150ml is adopted to be with the vacuum filtration instrument of nylon leaching film that the mixed liquor that (1) step is prepared is carried out Separation of Solid and Liquid.
In (3) step, the surface of the solid residue of (2) step collection uniformly sprays medicament and gathers iodine dimension ketone, wherein: drying 60 minutes at temperature is 40 DEG C.
Embodiment 5
Preparation method is with embodiment 1 for one bio-medical graphene oxide paper, wherein:
In (1) step, the quality (g) of graphene oxide: the quality (g) of auxiliary material: the volume (ml) of solvent is than being 1: 0.5: 100, and ultrasonic frequency is 300W, and the ultrasonic Separation time is 120 minutes.
Wherein: described auxiliary material is carbon fiber;
Described solvent is absolute ethyl alcohol.
In (2) step, 200ml is adopted to be with the vacuum filtration instrument of teflon membrane filter that the mixed liquor that (1) step is prepared is carried out Separation of Solid and Liquid.
In (3) step, uniform spraying medicine ceftriaxone sodium on the surface of the solid residue of (2) step collection, wherein: drying 60 minutes at temperature is 60 DEG C.
Result of the test
Carry out scanning electron microscopic observation, specific area and pore Structure Analysis, absorption property test to the bio-medical graphene oxide paper that embodiment 1 is prepared, its stereoscan photograph as shown in Figure 1.
From test result analysis, by the graphene-based paper of bio-medical of embodiment 1 gained, thickness is about 3mm, B.E.T. specific area is 158.88m
2/ g; Average pore size is 25.83nm, and aperture is mainly distributed between 10-50nm, good adsorption performance.
Claims (1)
1. a preparation method for bio-medical graphene oxide paper, is characterized in that the concrete steps of described method are as follows:
(1) sonic oscillation dispersion
With commercial graphene oxide for raw material, quality according to graphene oxide: the quality of auxiliary material: the ratio of the volume of solvent is the ratio of 1g: 0 ~ 1g: 20 ~ 10ml, graphene oxide and auxiliary material are joined in solvent, after stirring, under ultrasonic power output is 150 ~ 500W condition, carries out sonic oscillation dispersion 30 ~ 120 minutes and just obtain the dispersion mixed liquor of graphene oxide and auxiliary material;
(2) Separation of Solid and Liquid
After (1) step completes, the graphene oxide obtain (1) step and the dispersion mixed liquor of auxiliary material, adopt 100 ~ 300m1 to be with the vacuum filtration instrument of filter membrane to carry out Separation of Solid and Liquid, collect parting liquid and solid residue respectively;
(3) drug loading
After (2) step completes, even application medicament or spray medicine and obtain the solid residue that load has medicine on the solid residue that (2) step obtains, then load there is the solid residue of medicine, at temperature is 40 ~ 80 DEG C, drying 0.5 ~ 2 hour, just obtains bio-medical graphene oxide paper;
Described solvent is absolute ethyl alcohol or deionized water;
Described auxiliary material is CNT or activated carbon fiber or carbon fiber or carbon nano-fiber;
Described filter membrane is nylon leaching film or teflon membrane filter;
Described medicament is povidone-iodine or Povidone-Iodine Solution or the tincture of iodine, and medicine is Yunnan Baiyao or ceftriaxone sodium.
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| CN103449421B (en) * | 2013-08-23 | 2015-10-28 | 上海二工大资产经营有限公司 | A kind of preparation method of heat conductive insulating graphene oxide paper |
| CN103482621B (en) * | 2013-09-11 | 2016-01-20 | 黄镇东 | Oxidation or reduced graphene base macroscopic material and preparation method thereof |
| CN103482620B (en) * | 2013-09-11 | 2016-01-20 | 黄镇东 | Oxidation or reduced graphene base net grid material and preparation method thereof |
| CN104977194B (en) * | 2014-04-10 | 2018-08-14 | 北京雷根生物技术有限公司 | A method of addition graphene accelerates sample process |
| CN104129779A (en) * | 2014-06-27 | 2014-11-05 | 桂林浩新科技服务有限公司 | Preparation method of graphene-containing nano paper |
| CN105544306B (en) * | 2015-11-26 | 2017-06-13 | 张建刚 | A kind of preparation method containing graphene oxide antibiotic mildew-proof wallpaper |
| CN108421082A (en) * | 2018-04-23 | 2018-08-21 | 闫金银 | The preparation method of graphene oxide wound dressing with antibacterial anti-scar double action |
| CN109331780B (en) * | 2018-11-29 | 2021-03-30 | 长沙学院 | Preparation method of activated carbon fiber/graphene tube composite material |
| CN113652885A (en) * | 2021-07-19 | 2021-11-16 | 南京信息工程大学 | Preparation method and application of bacterial cellulose-reinforced graphene oxide paper |
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|---|---|---|---|---|
| CN1145257A (en) * | 1995-09-15 | 1997-03-19 | 清华大学 | Method of using expansion graphite as wound dressing |
| CN101670108A (en) * | 2009-08-13 | 2010-03-17 | 苏州纳米技术与纳米仿生研究所 | Medicine carrying system based on nano graphene oxide |
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| CN102417176A (en) * | 2011-09-06 | 2012-04-18 | 天津大学 | Preparation method of graphene-carbon nanotube compound film based on three-dimensional network appearance |
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| US8535726B2 (en) * | 2007-07-27 | 2013-09-17 | The Board Of Trustees Of The Leland Stanford Junior University | Supramolecular functionalization of graphitic nanoparticles for drug delivery |
| EP2660192B1 (en) * | 2010-12-30 | 2017-12-20 | Ocean's King Lighting Science&Technology Co., Ltd. | Graphene derivative-carbon nanotube composite material and preparation method thereof |
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|---|---|---|---|---|
| CN1145257A (en) * | 1995-09-15 | 1997-03-19 | 清华大学 | Method of using expansion graphite as wound dressing |
| CN102066245A (en) * | 2007-10-19 | 2011-05-18 | 卧龙岗大学 | Process for the preparation of graphene |
| CN101670108A (en) * | 2009-08-13 | 2010-03-17 | 苏州纳米技术与纳米仿生研究所 | Medicine carrying system based on nano graphene oxide |
| CN102417176A (en) * | 2011-09-06 | 2012-04-18 | 天津大学 | Preparation method of graphene-carbon nanotube compound film based on three-dimensional network appearance |
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