CN108295114A - 丹参茎叶中酚酸类及黄酮类成分的提取纯化方法 - Google Patents
丹参茎叶中酚酸类及黄酮类成分的提取纯化方法 Download PDFInfo
- Publication number
- CN108295114A CN108295114A CN201810305228.XA CN201810305228A CN108295114A CN 108295114 A CN108295114 A CN 108295114A CN 201810305228 A CN201810305228 A CN 201810305228A CN 108295114 A CN108295114 A CN 108295114A
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- China
- Prior art keywords
- salvia miltiorrhiza
- extraction
- phenolic acid
- miltiorrhiza stem
- purification
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 title claims abstract description 66
- 150000007965 phenolic acids Chemical class 0.000 title claims abstract description 54
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- 235000011949 flavones Nutrition 0.000 title claims abstract description 51
- 238000000605 extraction Methods 0.000 title claims abstract description 50
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- 238000000746 purification Methods 0.000 title claims abstract description 26
- 241000304195 Salvia miltiorrhiza Species 0.000 title claims abstract 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 79
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- 238000011084 recovery Methods 0.000 description 2
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- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
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- 235000005493 rutin Nutrition 0.000 description 2
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- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
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- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 235000010355 mannitol Nutrition 0.000 description 1
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
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- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810305228.XA CN108295114A (zh) | 2018-04-08 | 2018-04-08 | 丹参茎叶中酚酸类及黄酮类成分的提取纯化方法 |
Applications Claiming Priority (1)
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CN201810305228.XA CN108295114A (zh) | 2018-04-08 | 2018-04-08 | 丹参茎叶中酚酸类及黄酮类成分的提取纯化方法 |
Publications (1)
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CN108295114A true CN108295114A (zh) | 2018-07-20 |
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CN201810305228.XA Pending CN108295114A (zh) | 2018-04-08 | 2018-04-08 | 丹参茎叶中酚酸类及黄酮类成分的提取纯化方法 |
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CN (1) | CN108295114A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110124087A (zh) * | 2019-06-10 | 2019-08-16 | 江苏农林职业技术学院 | 基于流苏叶中黄酮类活性成分的创可贴的制备方法 |
CN112007073A (zh) * | 2020-09-09 | 2020-12-01 | 南京中医药大学 | 丹参茎叶酚酮有效部位的制备及其质量检测方法 |
CN112043746A (zh) * | 2020-09-09 | 2020-12-08 | 南京中医药大学 | 一种具有改善微循环障碍作用的丹参茎叶有效部位及其制备与应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101073599A (zh) * | 2007-06-18 | 2007-11-21 | 石任兵 | 丹参中总丹参酮及总酚酸提取物及其制备方法 |
US20120207862A1 (en) * | 2010-09-02 | 2012-08-16 | Morre D James | ORAL INHIBITORS OF AGE-RELATED NADH OXIDASE (arNOX), COMPOSITIONS AND NATURAL SOURCES |
-
2018
- 2018-04-08 CN CN201810305228.XA patent/CN108295114A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101073599A (zh) * | 2007-06-18 | 2007-11-21 | 石任兵 | 丹参中总丹参酮及总酚酸提取物及其制备方法 |
US20120207862A1 (en) * | 2010-09-02 | 2012-08-16 | Morre D James | ORAL INHIBITORS OF AGE-RELATED NADH OXIDASE (arNOX), COMPOSITIONS AND NATURAL SOURCES |
Non-Patent Citations (3)
Title |
---|
张雷红: "《天然药物化学》", 31 January 2017, 中国医药科技出版社 * |
曾慧婷: "丹参及丹参茎叶水提物UPLC指纹图谱研究与丹酚酸类成分定量分析", 《药物分析杂志》 * |
项想: "丹参茎叶酚酮有效部位的提取纯化工艺研究", 《中草药》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110124087A (zh) * | 2019-06-10 | 2019-08-16 | 江苏农林职业技术学院 | 基于流苏叶中黄酮类活性成分的创可贴的制备方法 |
CN112007073A (zh) * | 2020-09-09 | 2020-12-01 | 南京中医药大学 | 丹参茎叶酚酮有效部位的制备及其质量检测方法 |
CN112043746A (zh) * | 2020-09-09 | 2020-12-08 | 南京中医药大学 | 一种具有改善微循环障碍作用的丹参茎叶有效部位及其制备与应用 |
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