CN108137653A - 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 - Google Patents
有抗凝血和抗血小板活性的多靶点化合物及制法和用途 Download PDFInfo
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- CN108137653A CN108137653A CN201580082185.8A CN201580082185A CN108137653A CN 108137653 A CN108137653 A CN 108137653A CN 201580082185 A CN201580082185 A CN 201580082185A CN 108137653 A CN108137653 A CN 108137653A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
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Abstract
提供了一种抗凝血和拮抗血小板GPⅡb/Ⅲa受体多靶点化合物,其通式如下:A‑L‑B‑L’‑C,其中A和B为与凝血酶结合位点,C为与血小板GPⅡb/Ⅲa受体结合位点,L为第一连接基团,L’为第二连接基团。还提供了上述化合物的制备方法及其用途。所述化合物具有体外人凝血酶抑制活性、体外血小板GPⅡb/Ⅲa受体抑制作用以及体外/体内抗血小板聚集、体内抗凝血和抗血栓作用。
Description
PCT国内申请,说明书已公开。
Claims (22)
- PCT国内申请,权利要求书已公开。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110662995.8A CN113773369B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110661682.0A CN113201048B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110662996.2A CN113201049B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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PCT/CN2015/086173 WO2017020282A1 (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
Related Child Applications (3)
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CN202110662995.8A Division CN113773369B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110662996.2A Division CN113201049B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110661682.0A Division CN113201048B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN108137653A true CN108137653A (zh) | 2018-06-08 |
CN108137653B CN108137653B (zh) | 2021-07-13 |
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Family Applications (4)
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CN202110662996.2A Active CN113201049B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN201580082185.8A Active CN108137653B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110661682.0A Active CN113201048B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110662995.8A Active CN113773369B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
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CN202110662996.2A Active CN113201049B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
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CN202110661682.0A Active CN113201048B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
CN202110662995.8A Active CN113773369B (zh) | 2015-08-05 | 2015-08-05 | 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 |
Country Status (6)
Country | Link |
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US (1) | US11643439B2 (zh) |
EP (1) | EP3333177B1 (zh) |
JP (1) | JP6530564B2 (zh) |
CN (4) | CN113201049B (zh) |
ES (1) | ES2886576T3 (zh) |
WO (1) | WO2017020282A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3401356A1 (en) * | 2017-05-12 | 2018-11-14 | Solvay SA | Fluoropolymer hybrid composite |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003090733A1 (en) * | 2002-04-23 | 2003-11-06 | Vddi Pharmaceuticals | Inhibition of platelet aggregation |
CN1649625A (zh) * | 2002-03-01 | 2005-08-03 | 图兰恩教育基金管理人 | 治疗剂或细胞毒性剂与生物活性肽的偶联物 |
WO2006102069A3 (en) * | 2005-03-17 | 2007-02-01 | Microbia Inc | Methods and compositions for the treatment of hypertension and gastrointestinal disorders |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318899A (en) | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
GB9023149D0 (en) * | 1990-10-24 | 1990-12-05 | British Bio Technology | Proteins and nucleic acids |
US20070253966A1 (en) | 2003-06-12 | 2007-11-01 | Eli Lilly And Company | Fusion Proteins |
CN1810836A (zh) * | 2006-02-17 | 2006-08-02 | 北京师范大学 | 具有血小板GPⅡb-Ⅲa受体专一性的新型重组抗栓剂人胰岛素原-KGD嵌合肽的研制 |
CN101284877A (zh) | 2008-05-30 | 2008-10-15 | 重庆大学 | 重组靶向抗凝血酶活性和抗血小板聚集的融合蛋白及制备方法 |
US7803762B1 (en) * | 2009-08-20 | 2010-09-28 | The Medicines Company | Ready-to-use bivalirudin compositions |
WO2012050930A2 (en) | 2010-09-28 | 2012-04-19 | Amylin Pharmaceuticals, Inc | Engineered polypeptides having enhanced duration of action |
CN102241734B (zh) * | 2011-04-15 | 2014-04-02 | 广东医学院 | 一类抗凝血多肽及其应用 |
CN102241735B (zh) * | 2011-06-23 | 2014-01-22 | 陕西麦科奥特科技有限公司 | 用于预防及治疗急性冠脉综合症及抗凝抗血栓治疗的多肽及其应用 |
CN102702325B (zh) * | 2012-06-19 | 2015-09-23 | 深圳翰宇药业股份有限公司 | 一种抗凝血多肽的制备方法 |
CN107759662B (zh) * | 2013-08-28 | 2020-10-30 | 北京赛而生物药业有限公司 | 一种抗凝血化合物、其制备方法和用途、及包含其的药物组合物 |
CN104193807B (zh) * | 2014-09-28 | 2016-06-15 | 广州贝奥吉因生物科技有限公司 | 凝血酶抑制多肽及其制备方法、应用 |
CN104193809B (zh) * | 2014-09-28 | 2016-08-17 | 顾玉奎 | 一种凝血酶抑制及其制备方法、应用 |
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2015
- 2015-08-05 CN CN202110662996.2A patent/CN113201049B/zh active Active
- 2015-08-05 EP EP15900056.1A patent/EP3333177B1/en active Active
- 2015-08-05 US US15/749,622 patent/US11643439B2/en active Active
- 2015-08-05 WO PCT/CN2015/086173 patent/WO2017020282A1/zh active Application Filing
- 2015-08-05 CN CN201580082185.8A patent/CN108137653B/zh active Active
- 2015-08-05 JP JP2018526284A patent/JP6530564B2/ja active Active
- 2015-08-05 CN CN202110661682.0A patent/CN113201048B/zh active Active
- 2015-08-05 CN CN202110662995.8A patent/CN113773369B/zh active Active
- 2015-08-05 ES ES15900056T patent/ES2886576T3/es active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1649625A (zh) * | 2002-03-01 | 2005-08-03 | 图兰恩教育基金管理人 | 治疗剂或细胞毒性剂与生物活性肽的偶联物 |
WO2003090733A1 (en) * | 2002-04-23 | 2003-11-06 | Vddi Pharmaceuticals | Inhibition of platelet aggregation |
WO2006102069A3 (en) * | 2005-03-17 | 2007-02-01 | Microbia Inc | Methods and compositions for the treatment of hypertension and gastrointestinal disorders |
Non-Patent Citations (1)
Title |
---|
高文静,等: "糖蛋白Ⅱb/Ⅲa抑制剂治疗急性心肌梗死的临床研究进展", 《药学服务与研究》 * |
Also Published As
Publication number | Publication date |
---|---|
EP3333177B1 (en) | 2021-07-14 |
CN113773369B (zh) | 2022-11-08 |
CN108137653B (zh) | 2021-07-13 |
CN113201049B (zh) | 2022-10-04 |
US11643439B2 (en) | 2023-05-09 |
CN113201049A (zh) | 2021-08-03 |
JP2018525442A (ja) | 2018-09-06 |
ES2886576T3 (es) | 2021-12-20 |
EP3333177A4 (en) | 2018-12-26 |
CN113201048A (zh) | 2021-08-03 |
CN113773369A (zh) | 2021-12-10 |
CN113201048B (zh) | 2022-10-04 |
JP6530564B2 (ja) | 2019-06-12 |
EP3333177A1 (en) | 2018-06-13 |
US20180305409A1 (en) | 2018-10-25 |
WO2017020282A1 (zh) | 2017-02-09 |
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