CN108042420B - Composition for oral health care and application thereof - Google Patents
Composition for oral health care and application thereof Download PDFInfo
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- CN108042420B CN108042420B CN201711386699.XA CN201711386699A CN108042420B CN 108042420 B CN108042420 B CN 108042420B CN 201711386699 A CN201711386699 A CN 201711386699A CN 108042420 B CN108042420 B CN 108042420B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention relates to the technical field of daily chemical products, in particular to a composition for oral health care and application thereof. The composition comprises the following components in parts by weight: 0.001-15 parts of chamomile tincture, 0.001-12 parts of latanib extract and 0.002-10 parts of myrrh tincture. The composition provided by the invention can further comprise one or more of soapberry extract, cudrania tricuspidata phenol, o-cymene-5-alcohol, thymol and paeonol. The composition provided by the invention has excellent antibacterial effect, can be used for preparing oral health products or medicaments, can clean oral cavities, can kill helicobacter pylori, has good treatment effect on halitosis, and can obviously inhibit dental plaque.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to a composition for oral health care and application thereof.
Background
Halitosis, also known as halitosis, refers to foul breath exhaled from the mouth. Because bad breath is often boring and embarrassing, people with bad breath (especially young people) are afraid to deal with people at a short distance, which seriously affects social interaction and mental health of people, and at present, the WHO reports the bad breath as a disease. According to survey, the prevalence rate of halitosis in China is 27.5%, and in western countries, 50%, and 10% to 65% of people worldwide have had halitosis.
The types of halitosis can be divided into physiological halitosis and pathological halitosis. Physiological halitosis is caused by that oral hygiene is not noticed in daily life, food residues in the mouth are accumulated for a long time, and are fermented, decayed and decomposed under the action of bacteria to generate substances such as indole sulfhydryl and amine, and the like, so that decayed malodor is generated. Physiological bad breath can be removed by enhancing oral hygiene without special treatment. The pathological halitosis can be caused by oral cavity problems such as dental plaque, dental caries and the like on one hand, and can be caused by medical diseases such as acute and chronic gastritis, sour and stink generated by peptic ulcer and the like on the other hand. The infection of helicobacter pylori is the important cause of acute and chronic gastritis. Helicobacter pylori can enter from the mouth, deposit in the oral cavity, enter the stomach through swallowing action, colonize and infect after reaching gastric mucosa, cause chronic and superficial gastritis for weeks or months, and develop into duodenal ulcer, gastric ulcer, lymphoproliferative gastric lymphoma, chronic atrophic gastritis and the like after years or decades, and the latter is the most dangerous factor causing gastric cancer. And after stomach diseases appear, the halitosis problem can be caused. Therefore, the treatment of pathological halitosis needs to be started from oral diseases and medical diseases, and the treatment is carried out fundamentally.
The invention develops an oral product capable of removing halitosis in all directions, which can remove bacteria in the oral cavity, inhibit dental plaque, kill helicobacter pylori in the oral cavity and simultaneously assist in shortening the stomach problem caused by the helicobacter pylori, and has very important significance for patients with halitosis.
Disclosure of Invention
The invention provides a composition for oral health care, which can not only clean the oral cavity, but also kill helicobacter pylori, simultaneously eliminate bacteria in the oral cavity, inhibit dental plaque, assist in shortening the stomach problem caused by the helicobacter pylori, and solve the problem of halitosis from an external source and an internal source.
The composition of the invention comprises:
0.001-15 parts by weight of chamomile tincture,
0.001 to 12 parts by weight of a latanib extract,
0.002-10 parts by weight of myrrh tincture.
Preferably, the composition comprises:
0.5-4 parts of chamomile tincture,
0.5 to 4 parts by weight of a latanib extract,
0.1-1 part by weight of myrrh tincture.
Among the components used in the present invention, chamomile tincture is a dried whole plant extract of chamomile Matricaria chamomilla l. a feverfew, which mainly contains active ingredients such as flavone, saponin, polysaccharide, volatile oil, etc., and has inhibitory activity against staphylococcus aureus, streptococcus, candida albicans, etc.
Latanib has been used since ancient times by peru to treat oral inflammation and injury. The root extract of latanib is rich in benzofuran content, ellagitannin and protocatechuic tannin, and can inhibit reproduction of various microorganisms, especially gram-positive bacteria and fungi. The ratanhia extract adopted by the invention is an alcohol extract or a water extract of ratanhia root, and preferably the alcohol extract.
The myrrh tincture contains eugenol and various functional components and has certain antibacterial effect.
The invention creatively discovers that the combination of the components according to the specific ratio can obtain the composition with better effect than the combination of single or two components, which indicates the synergistic effect of the three components.
Preferably, the composition of the present invention further comprises one or more selected from the group consisting of soapberry extract, totarol, o-cymene-5-ol, thymol and paeonol.
Wherein, when any of the above components is selected, it is used in the composition in an amount of:
preferably, the components are present in the composition in amounts of:
the soapberry is a common natural washing product in China all the time from ancient times and has the effects of inhibiting bacteria, removing dandruff, preventing alopecia, whitening skin, removing speckles, moistening skin and the like, and the soapberry extract is an extract of soapberry ethanol and/or water.
The totarol is a core material extracted from totaro cudrania Tricuspidata Thunb, is a natural plant bactericide, has excellent activity against gram-negative bacteria and gram-positive bacteria, and has high inhibitory activity against bacteria causing dental caries and halitosis.
O-cymene-5-ol is effective component of Rhododendron pulchrum Maxim (Ledum palustre L. var dillatatumwahlanberg) of Ericaceae, has expectorant and antiinflammatory effects, and can be used as antiseptic.
Thymol can be extracted from essential oil of multiple plants (such as thyme) and has antibacterial effect. The Thymol is preferably WellcapTThymol which is a Thymol nano microcapsule manufactured by adopting WellcapTM technology, and the stability and the antibacterial capacity of the Thymol can be improved.
Paeonol is the main functional component of cortex moutan, has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and relieving deficiency heat, and has antibacterial activity.
The present invention has surprisingly found that the effect of the composition can be further improved by adding one or more of soapberry extract, totarol, o-cymene-5-ol, thymol and paeonol to the composition.
As a preferred embodiment of the present invention, there is provided a composition formulated as follows:
the composition adopting the formula can exert the synergistic effect of each component to the maximum extent.
Most preferably, the following:
the invention also provides application of the composition in preparing a medicine or an oral health product for treating halitosis.
In particular to the application of any composition in the technical scheme in the preparation of oral health products.
The invention also provides an oral health product which comprises any one of the compositions in the technical scheme.
The present invention also provides a mouthwash comprising:
the humectant is selected from one or more of sorbitol, propylene glycol, glycerol and polyethylene glycol-8;
the surfactant is selected from one or more of poloxamer 407, sodium lauryl sulfate, sodium lauroyl sarcosinate and sodium cocoyl methyl taurate;
the thickening agent is selected from one or more of cellulose, carbomer and carrageenan;
the edible essence is selected from one or more of flos Caryophylli, cortex Cinnamomi, flos Osmanthi Fragrantis, oleum Menthae Dementholatum, herb Hierochloes Adoratae essence, herba Menthae Rotundifoliae, herba Menthae Haplocalycis, and herba Menthae Dementholati;
the color of the colorant is selected from one or more of green, blue and red.
Preferably, the above mouthwashes further comprise any one or more of the following components, when any is selected, in the following amounts in the composition:
by adding the components, the mouthwash provided by the invention can effectively kill helicobacter pylori in the mouth, inhibit dental plaque and shorten the time required for curing gastric ulcer by auxiliary medicines, thereby showing an excellent effect of removing halitosis.
Preferably, the components are present in the composition in amounts of:
the components are dissolved in a solvent, and the solvent is deionized water; preferably up to 100 parts by weight of the solvent.
As a preferred scheme of the invention, the mouthwash is provided, the total weight parts are 100 parts, and the formula is as follows:
the mouthwash provided by the above is capable of maximally utilizing the synergistic effect of each component thereof by specially selecting the components and matching with the regulation and control of the weight parts, and has a better effect of treating or assisting in treating oral diseases.
The invention also provides a preparation method of the mouthwash, and the mouthwash is prepared by mixing the components. The preparation method can be prepared by adopting a conventional method, the invention is not particularly limited, and only provides a more preferable preparation method:
the method comprises the following specific steps:
1) dispersing the thickening agent into the humectant, adding deionized water, heating to 90 ℃ for sterilization, and stirring and dispersing uniformly.
2) Adding a surfactant, dissolving and dispersing uniformly, and then cooling.
3) Cooling to 38 deg.C, adding ethanol, flos Chrysanthemi tincture, Latanini extract, Myrrha tincture, edible essence, and colorant, stirring, and filtering.
The invention provides a toothpaste, comprising:
the abrasive is selected from one or more of silicon dioxide, hydrated calcium hydrophosphate, anhydrous calcium hydrophosphate, calcium carbonate, aluminum hydroxide and calcium pyrophosphate;
the humectant is selected from one or more of sorbitol, glycerol, propylene glycol, polyethylene glycol-8 and butanediol;
the foaming agent is selected from one or more of sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium cocoyl glycinate, sodium acyl glutamate and sodium cocoyl methyl taurate;
the thickening agent is selected from one or more of cellulose and derivatives thereof, guar gum, sodium alginate, xanthan gum, guar gum hydroxypropyl trimethyl ammonium chloride, carrageenan and locust bean gum;
the sweetener is selected from one or more of saccharin sodium, sucralose, xylitol, sodium cyclamate, aspartame, stevioside and mogroside;
the essence is selected from one or more of vanilla essence, spearmint, mint and wintergreen mint;
the preservative is selected from one or more of benzoic acid and salts thereof, sorbic acid and salts thereof and parabens;
the appearance modifier is selected from one or more of titanium dioxide, food pigment, food color lake and tooth cleaning particles;
the components are dissolved in a solvent, and the solvent is deionized water; preferably, the solvent is used to make up to 100 parts.
Preferably, the toothpaste comprises a solvent and the following components:
and one or more selected from soapberry extract, totarol, o-cymene-5-ol, thymol and paeonol, wherein when any one component is selected, the following components are used in the composition:
preferably, the first and second electrodes are formed of a metal,
the toothpaste provided by the invention has the effects of removing bacteria and inhibiting dental plaque in the oral cavity, killing helicobacter pylori in the oral cavity and has the advantage of comprehensively removing halitosis.
The invention also provides a preparation method of the toothpaste, which comprises the following steps: mixing the above materials, and making toothpaste. The method comprises the following specific steps:
1) dissolving chamomile tincture, latanib extract and myrrh tincture in a humectant, and stirring at high speed to prepare a first mixed solution;
2) adding a thickening agent into the first mixed solution, and stirring to obtain a second mixed solution;
3) adding an appearance modifier into the second mixed solution, and stirring to obtain a third mixed solution;
4) adding the third mixed solution, the sweetening agent, the friction agent, the essence, the foaming agent and the preservative into the solvent, and stirring to obtain a fourth mixed solution;
5) the fourth mixed solution is continuously stirred under the vacuum condition of 0.08-0.12MPa to prepare paste.
6) Checking, aseptically filling into aluminum plastic composite tube, sealing, and making into toothpaste.
The composition provided by the invention comprises chamomile tincture, Latany extract and myrrh tincture, and the composition has the functions of efficiently eliminating halitosis caused by various ways, including killing helicobacter pylori, eliminating dental plaque, assisting in treating gastric ulcer and the like by screening specific components, combining different medicinal mechanisms of different components according to specific proportions and fully utilizing the synergistic effect among the components.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The embodiment provides a composition for oral health, which comprises the following specific components:
2 parts of chamomile tincture, namely,
2 parts of a latanib extract, namely latanib,
0.85 portion of myrrh tincture.
Example 2
The embodiment provides a composition for oral health, which comprises the following specific components:
example 3
The embodiment provides a composition for oral health, which comprises the following specific components:
example 4
The embodiment provides a composition for oral health, which comprises the following specific components:
example 5
The embodiment provides a composition for oral health, which comprises the following specific components:
example 6
The embodiment provides a composition for oral health, which comprises the following specific components:
example 7
The embodiment provides a composition for oral health, which comprises the following specific components:
example 8
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 9
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 10
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 11
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 12
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 13
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 14
The embodiment provides a mouthwash, which comprises the following specific components in parts by weight of 100:
example 15
The embodiment provides toothpaste, which comprises the following specific components in parts by weight of 100:
example 16
The embodiment provides toothpaste, which comprises the following specific components in parts by weight of 100:
example 17
The embodiment provides toothpaste, which comprises the following specific components in parts by weight of 100:
example 18
The embodiment provides toothpaste, which comprises the following specific components in parts by weight of 100:
example 19
The embodiment provides toothpaste, which comprises the following specific components in parts by weight of 100:
comparative examples 1 to 5
Comparative examples 1 to 5 provide compositions for oral care, the specific components of which are as follows:
comparative examples 6 to 10
Comparative examples 6-10 provide formulations for mouthwashes as follows:
comparative example 11
The comparative example provides a formulation of mouthwash, the total weight of which is 100g, the formulation being as follows:
mixing the above materials, filtering with 0.22 μm filter membrane, and making into collutory.
Test example 1
The experimental examples provide bacteriostatic experiments and data on the compositions provided in examples 1-5 and comparative examples 1-5.
1. Preparation of a culture medium:
preparation of a helicobacter pylori liquid culture medium: weighing 10.0g of lunar indicum peptone; 10.0g of bovine brain extract powder; 9.0g of bovine heart extract powder; 5.0g of sodium chloride; 2.0g of glucose; 2.5g of disodium hydrogen phosphate is dissolved by distilled water, the volume is fixed to 1000g, the mixture is autoclaved at 121 ℃ for 15 minutes, 7ml of sterile defibrinated sheep blood and 1 HP bacteriostatic agent (containing 1mg of nalidixic acid, 0.5mg of TMP, 0.3mg of vancomycin and 0.2mg of amphotericin) are added when the mixture is cooled to 50-55 ℃, and the mixture is uniformly mixed and subpackaged for later use.
Preparation of helicobacter pylori solid medium: a solid medium was prepared in the same manner by adding 1.5% agar powder to the above liquid medium.
2. And (3) bacteriostatic test:
strain activation: 0.1ml of freeze-thawed helicobacter pylori (Hp) stock strain was spread on a solid medium of helicobacter pylori (Hp) in a microaerophilic environment (N) at 36 ℃285％,CO210％,O25%) for 72 h.
Preparation of the bacterial suspension: taking a ring of activated helicobacter pylori in 10ml helicobacter pylori liquid culture medium, and placing in microaerophilic environment (N)285％,CO210％,O25%) until the concentration of bacteria reaches 1 × 108CFU ml-1。
Preparation of a liquid culture medium containing the composition: 4.85g of the compositions of comparative examples 1 to 5 and examples 1 to 5 were weighed out, respectively, and dissolved in a liquid culture medium of helicobacter bacteria to make up 100 g.
And (3) bacteriostatic test: adding 1ml of the suspension to 100g of a liquid culture medium containing different compositions, and using the liquid culture medium of the bacteria without the composition as a blank in a microaerophilic environment (N)285％,CO210％,O25%) and then measuring the OD value of the bacteria liquid by using a spectrophotometer after 3d of culture, and calculating the bacteriostasis rate of each composition according to the formula of (blank control OD value-composition OD value)/blank control OD value × 100% by 100%.
The bacteriostatic effect is shown in table 1:
TABLE 1 Experimental data for bacteriostatic effect of different compositions
From the above results, it is understood that the compositions of the examples have strong inhibitory activity against the proliferation and growth of helicobacter pylori.
Test example 2
The test example provides the human body test (treatment effect on dental plaque) of the mouthwashes provided in examples 8 to 14 and comparative examples 6 to 11, and data thereof.
Volunteers with dental plaque were selected for human trial trials. Before trial, the severity of dental plaque of volunteers is evaluated, the volunteers are divided into groups according to the severity of dental plaque, 25 persons are in each group, different mouth washes are tried respectively in each group, the mouth washes are used once in the morning and at night every day, and the severity of dental plaque is evaluated again after 6 months.
The severity scoring criteria for dental plaque were as follows:
0 minute: has no bacterial plaque.
1 minute: the plaque is located at the neck of the tooth and distributed in the form of scattered spots.
And 2, dividing: the plaque is located in the neck of the tooth and is linear with a width of 1 mm.
And 3, dividing: the width of the plaque was > 1 mm, but did not reach l/3 of the crown.
And 4, dividing: the plaque reached l/3 of the crown, but not 2/3 of the crown.
And 5, dividing: the plaque width reached 2/3 or more of the crown.
The results are shown in table 2:
table 2 plaque scoring before and after use of different mouthwashes
Test example 3
The experimental example provides human tests (effect of adjuvant therapy for gastric ulcer) of the mouthwashes provided in examples 8 to 14 and comparative examples 6 to 11 and data thereof.
The patients who have more than 2 years of history of gastric ulcer, repeatedly attack and are in the attack period and the attack time is within 48 hours are selected to take the auxiliary treatment effect of the mouthwash on the gastric ulcer. The treatment method comprises the steps of randomly grouping according to the number of test samples, using 25 persons in each group, using the mouth wash in the embodiment and the comparative example respectively, using the mouth wash once in the morning and at the evening every day, simultaneously taking the same dose of the gastric bismuth magnesium, counting the healing time of gastric ulcer, and counting the recurrence rate of the gastric ulcer within 12 months after self healing.
The results are shown in Table 3:
TABLE 3 adjuvant treatment of gastric ulcer with different mouthwashes
Test example 4
The test example provides the human tests (treatment effect on halitosis) of the mouthwashes provided in examples 8 to 14 and comparative examples 6 to 11, and data thereof.
Volunteers with severe pathological halitosis (volunteers with various halitosis types) were selected to participate in the test of the treatment effect of mouthwash on halitosis. Before trial, volunteers are scored and randomly grouped into 25 persons in each group, different mouthwashes are tried in each group respectively, and are scored once in the morning and at night every day, and halitosis is scored again after 30 days. Halitosis scoring the scoring protocol of Rosenberg was used, as follows:
0 point, no halitosis, and definitely no odor.
Score 1, suspected bad breath, similar to an audible smell.
2 points, slight halitosis, definitely smells bad smell, but very slight.
Score 3, moderate halitosis, obvious halitosis.
4 points, severe halitosis, but it is barely tolerated by the examiners.
5 points out strong odor, which is intolerable to the examiners.
The results are shown in Table 4:
TABLE 4 therapeutic Effect on pathological halitosis after using different mouthwashes
From the above results, it is understood that the mouth wash containing the composition of the example can effectively kill helicobacter pylori in the mouth, inhibit plaque, and shorten the time required for the gastric ulcer to heal by the adjuvant drug, thereby exhibiting excellent effects.
Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that many modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (4)
1. The mouthwash is characterized by comprising the following active ingredients in parts by weight:
1 to 1.5 portions of chamomile tincture,
1-1.5 parts of latanib extract,
0.5 to 0.8 portion of myrrh tincture,
0.3 to 0.7 portion of soapberry extract,
0.01 to 0.02 portion of cudrania tricuspidata phenol,
0.2 to 0.5 portion of o-cymene-5-alcohol,
0.1 to 0.2 portion of thymol,
0.1-0.2 part of paeonol.
2. The mouthwash according to claim 1, further comprising one or more selected from the group consisting of 0 to 10 parts by weight of a humectant, 0 to 5 parts by weight of a surfactant, 0 to 5 parts by weight of a thickener, 0 to 25 parts by weight of ethanol, 0 to 5 parts by weight of a flavoring essence, and 0 to 1 part by weight of a coloring agent.
3. The mouthwash according to claim 1, further comprising, in parts by weight:
1-10 parts of a humectant, namely,
0.5 to 215 portions of surface active agent,
1-5 parts of a thickening agent,
1-25 parts of ethanol, namely,
1-5 parts of edible essence,
0.001-1 part of a coloring agent;
the total weight portion is 100 portions;
the humectant is selected from one or more of sorbitol, propylene glycol, glycerol and polyethylene glycol-8;
the surfactant is selected from one or more of poloxamer 407, sodium lauryl sulfate, sodium lauroyl sarcosinate and sodium cocoyl methyl taurate;
the thickening agent is selected from one or more of cellulose, carbomer and carrageenan;
the edible essence is selected from one or more of flos Caryophylli, cortex Cinnamomi, flos Osmanthi Fragrantis, oleum Menthae Dementholatum, herb Hierochloes Adoratae essence, herba Menthae Rotundifoliae, herba Menthae Haplocalycis, and herba Menthae Dementholati;
the color of the colorant is selected from one or more of green, blue and red.
4. The mouthwash according to any one of claims 1 to 3, wherein the formulation comprises the following components in parts by weight based on 100 parts by weight:
1.1 to 1.3 portions of chamomile tincture,
1.1-1.4 parts of latanib extract,
0.5 to 0.8 portion of myrrh tincture,
0.3 to 0.6 portion of soapberry extract,
0.01 to 0.02 portion of cudrania tricuspidata phenol,
0.2 to 0.4 portion of o-cymene-5-alcohol,
0.1 to 0.2 portion of thymol,
0.1 to 0.2 portion of paeonol,
1-10 parts of sorbitol (sugar) alcohol,
4070.5-2 parts of poloxamer, namely,
1-5 parts of cellulose, wherein the cellulose is cellulose,
1-25 parts of ethanol, namely,
1-5 parts of mint fragrance,
0.001 to 1 portion of blue color,
the balance of deionized water.
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| CN109010404A (en) * | 2018-09-26 | 2018-12-18 | 广东南方洁灵科技实业有限公司 | A kind of anti-helicobacter pylori oral cavity compound and its preparation method and application |
| CN110478298A (en) * | 2019-09-23 | 2019-11-22 | 沈阳天然纳美科技有限公司 | A kind of composition and its preparation method and application with oral health function |
| CN110613631A (en) * | 2019-10-28 | 2019-12-27 | 青岛明月海藻生物健康科技集团有限公司 | Fucoidin delicate antibacterial composition for oral care products |
| CN114948805A (en) * | 2021-02-23 | 2022-08-30 | 上海昆药生物科技有限公司 | Antibacterial composition containing sweet wormwood herb volatile oil and application of antibacterial composition in acne-removing skin care product |
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|---|---|---|---|---|
| WO2018066707A1 (en) * | 2016-10-07 | 2018-04-12 | 株式会社 Ｐａｌ | Aging inhibitor, soft-tissue calcification inhibitor, and lung tissue destruction inhibitor |
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| CN108042420A (en) | 2018-05-18 |
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