A kind of oral care implement that contains totarol
Technical field
The present invention relates to oral care product field, particularly relate to and contain totarol as the oral care product of active sterilization component.
Background technology
Oral care implement is a clean beautification function indispensable in people's daily life, and can assist the product that prevents or alleviate oral problem, mainly comprises toothpaste, collutory, dentifrice, oral spray, chewing gum etc.Owing to containing nutritional labeling and moisture in raw material, additive, these are growth of microorganism, it is necessary to breed.In production and use procedure, when condition is permitted, microbes growth and breeding, causes the oral care implement sense organs such as toothpaste, collutory and quality to change, and causes going bad.Safety in order to ensure the stable of nursing materials and consumer's use, will reach the efficacy effect that nursing materials is antibacterial, sterilize in addition, must in product, add and have functional component antibacterial, sterilization.
The dental plaque that oral cavity bacterium forms has the structure of high-sequential, and every gram contains 1012 antibacterials that yard up, and also has in addition the materials such as polysaccharide, phospholipid and protein.Although antibacterial does not endanger gums conventionally, its metabolite can cause oral cavity tissue generation pathological change.1890, father's Miller of dentistry microbiology just pointed out, should kill antibacterial in oral cavity to reach the object of control dental disorder with antibacterial.The kind that inserts the antibacterial in toothpaste once had antibiotics, antiseptic and anti-inflammatory agent etc., but effect is bad, and had obvious side effect, can upset the normal ecological environment of oral microorganism.Bactericidal action is not only in order to prevent the generation of bacterial plaque.Effectively antibacterial should have the antibacterial activity of wide spectrum; Can remain on oral mucosa and tooth; Good taste; Low toxicity; And do not upset the ecological environment of the normal microorganism in oral cavity.
At present, the oral care implement that lacks the sterilization component that uses efficiency natural on market, not only clean and beautify tooth, and can assist prevention or alleviate oral problem, effectively sterilization, can also keep oral care implement stable, safety, and on human body nonhazardous, do not affect the normal microorganism ecological environment in oral cavity.
Summary of the invention
The invention provides the oral care implement that contains totarol, totarol has effect antibacterial, sterilization as the raw material of natural plant active component, totarol is joined in the oral care product of toothpaste, collutory as active component antibacterial, antibacterial, can play the effect that prevents and safeguard oral cavity total health.
Technical scheme of the present invention provides a kind of oral care implement that contains totarol, contains totarol, and the percentage by weight of totarol in oral care implement is 0.001-0.05%.
Preferably, described oral care implement is toothpaste or collutory.
Preferably, described toothpaste also comprises following component, by weight percentage: abrasive material 0-65%, sorbitol 15-70%, PEG-4000 2-10%, glycerol 0-15%, thickening agent 0.2-1.3%, sodium lauryl sulfate 1.8-2.5%, saccharin sodium 0.2-0.3%, tetrasodium pyrophosphate 0.2-2.0%, pigment 0-0.3%, essence 0.5-2.0%.
Preferably, to be selected from be silicon dioxide or calcium carbonate to abrasive material.
Preferably, to be selected from be one or more mixing of sodium carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, carrageenan, guar gum to thickening agent.
Preferably, described collutory also comprises following component, by weight percentage: sorbitol 5-20%, glycerol 3-15%, ethanol 0-15%, poloxamer 0.5-3%, saccharin sodium 0.03-0.5%, pigment 0.0001-0.2%, essence 0.1-0.5%.
Beneficial effect of the present invention has:
1) totarol (Totarol) is used supercritical CO
2the natural activity product that technology extracts from the core of Fructus Persicae three-bristle cudrania Semen Podocarpi Macrophylli, is rich in fragrant diterpene; Its per os is tasteless, has slight aromatic odor.Totarol is extensively by independent experiment chamber authentification, and result of study shows that it has efficient bio-active, human safety and formula for a product compatibility.Totarol is a kind of natural bactericide, there is outstanding anti-gram negative bacteria, the activity of positive bacteria, the diluent of 0.005% concentration has 98.9% killing rate to propionibacterium acnes, in addition it also has efficient antioxidant, peroxidization Scavenger of ROS (ROS) that can oil-control.This natural plants antibacterial, because it has good bacteriostatic activity and non-oxidizability, more and more receives people's concern.Totarol has good antibiotic property, can effectively suppress the growth of pathogenic bacterium and oral cavity noxious bacteria, to preventing oral disease and safeguarding that oral cavity total health has good effect.
2) totarol of low concentration has good fungistatic effect, and totarol concentration is elevated to 0.05% by 0.001%, and the fungistatic effect tool of toothpaste and collutory improves, and amplitude stabilization.When totarol concentration reaches 0.1% from 0.05% raising, or even 0.5% time, the fungistatic effect of toothpaste and collutory is not significantly improved.So the present invention selects the concentration range of 0.001-0.05%, not only avoided the waste of totarol, also make antibiotic and sterilizing effect reach best.
3) antibacterial of high concentration easily causes antibacterial to produce drug resistance under pressure.Therefore, in oral care product, use the totarol of low concentration not only can reach good fungistatic effect, and can avoid or reduce the generation of oral cavity bacterium drug resistance.
The specific embodiment
Below by embodiment, the present invention will be further described, and its object is only better to understand content of the present invention but not limits the scope of the invention.
Specific embodiment one
The application of totarol of the present invention in toothpaste:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.005 |
Sorbitol |
15.0 |
Glycerol |
2.0 |
PEG-4000 |
2.0 |
Calcium carbonate |
65.0 |
[0020]?
Sodium carboxymethyl cellulose |
0.2 |
Sodium lauryl sulfate |
2.5 |
Saccharin sodium |
0.25 |
Tetrasodium pyrophosphate |
0.2 |
Pigment |
0.3 |
Essence |
1.1 |
Deionized water |
11.445 |
The preparation method of toothpaste:
Lotion of toothpaste can adopt the one-step method of conventional toothpaste cream production technology processed to make, and in the end the stage is dissolved in essence by totarol and adds in mastic and stir.
Specific embodiment two
The application of totarol of the present invention in toothpaste:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.001 |
Sorbitol |
70.0 |
PEG-4000 |
4.0 |
Silicon dioxide |
16 |
Hydroxyethyl-cellulose |
0.65 |
Sodium lauryl sulfate |
2.2 |
Saccharin sodium |
0.2 |
Tetrasodium pyrophosphate |
1.0 |
Coolant agent |
0.03 |
Pigment |
0.1 |
Essence |
0.5 |
Deionized water |
5.319 |
The preparation method of toothpaste:
Lotion of toothpaste can adopt the one-step method of conventional toothpaste cream production technology processed to make, and in the end the stage is dissolved in essence by totarol and adds in mastic and stir.
Specific embodiment three
The application of totarol in toothpaste:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.05 |
Sorbitol |
35.0 |
Glycerol |
10.0 |
PEG-4000 |
10.0 |
Silicon dioxide |
20.0 |
Xanthan gum |
0.8 |
Sodium carboxymethyl cellulose |
0.5 |
Sodium lauryl sulfate |
1.8 |
Saccharin sodium |
0.3 |
Tetrasodium pyrophosphate |
2.0 |
Essence |
2.0 |
Deionized water |
17.55 |
The preparation method of toothpaste:
Lotion of toothpaste can adopt the one-step method of conventional toothpaste cream production technology processed to make, and in the end the stage is dissolved in essence by totarol and adds in mastic and stir.
Specific embodiment four
The application of totarol in toothpaste:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.009 |
Sorbitol |
50.0 |
Glycerol |
15.0 |
PEG-4000 |
8.0 |
Calcium carbonate |
17.0 |
Carrageenan |
0.3 |
Guar gum |
0.3 |
Sodium carboxymethyl cellulose |
0.7 |
Sodium lauryl sulfate |
2.0 |
Saccharin sodium |
0.3 |
Tetrasodium pyrophosphate |
1.5 |
Pigment |
0.2 |
Essence |
1.5 |
The preparation method of toothpaste:
Lotion of toothpaste can adopt the one-step method of conventional toothpaste cream production technology processed to make, and in the end the stage is dissolved in essence by totarol and adds in mastic and stir.
Specific embodiment five
The application of totarol in collutory:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.001 |
Sorbitol |
5.0 |
Glycerol |
15.0 |
Poloxamer |
0.5 |
Methyl hydroxybenzoate |
0.1 |
Propylparaben |
0.02 |
Saccharin sodium |
0.5 |
Freshener |
0.02 |
Pigment |
0.2 |
Essence |
0.2 |
Deionized water |
78.459 |
The preparation method of collutory:
Adopt existing collutory production technology, in the end the stage together adds stirring and evenly mixing in collutory by totarol and essence.
Specific embodiment six
The application of totarol in collutory:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.05 |
Sorbitol |
20.0 |
Glycerol |
3.0 |
Ethanol |
8.0 |
Poloxamer |
1.2 |
Sodium benzoate |
0.15 |
Saccharin sodium |
0.15 |
[0047]?
Pigment |
0.05 |
Essence |
0.5 |
Deionized water |
66.9 |
The preparation method of collutory:
Adopt existing collutory production technology, in the end the stage together adds stirring and evenly mixing in collutory by totarol and essence.
Specific embodiment seven
The application of totarol in collutory:
Constituent |
Constituent percentage by weight (%) |
Totarol |
0.005 |
Sorbitol |
10.0 |
Glycerol |
10.0 |
Ethanol |
15.0 |
Poloxamer |
3.0 |
Sodium benzoate |
0.15 |
Saccharin sodium |
0.03 |
Pigment |
0.0001 |
Essence |
0.1 |
Deionized water |
61.7149 |
The preparation method of collutory:
Adopt existing collutory production technology, in the end the stage together adds stirring and evenly mixing in collutory by totarol and essence.
Specific embodiment eight
Toothpaste containing different totarol concentration is carried out to Oxford cup inhibition zone test, to compare the diversity of its bacteriostasis property.Toothpaste is configured to measure after dentifrice slurry by solid-to-liquid ratio (1:1), and test result is as shown in table 1.
Table 1 dentifrice slurry is to 5 kinds of antibacterial circle diameters (mm) for examination bacterium
Specific embodiment nine
Toothpaste minimum inhibitory concentration (MIC) containing different totarol concentration is measured, to compare the diversity of its bacteriostasis property.Toothpaste is configured to measure after dentifrice slurry by solid-to-liquid ratio (1:1), and test result is as shown in table 2.
Table 2 dentifrice slurry is to 5 kinds of MIC values (ppm) for examination bacterium
Specific embodiment ten
By the collutory to containing different totarol concentration, carry out Oxford cup inhibition zone and test, to compare the diversity of its bacteriostasis property.Directly adopt stock solution to measure collutory, test result is as shown in table 3.
Table 3 collutory is to 5 kinds of antibacterial circle diameters (mm) for examination bacterium
Specific embodiment 11
By the collutory to containing different totarol concentration, carry out minimum inhibitory concentration (MIC) and measure, to compare the diversity of its bacteriostasis property.Directly adopt stock solution to measure collutory, test result is as shown in table 4.
Table 4 collutory is to 5 kinds of MIC values (ppm) for examination bacterium
The announcement of book and instruction according to the above description, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the present invention is not limited to the specific embodiment disclosed and described above, to modifications and changes more of the present invention, also should fall in the protection domain of claim of the present invention.In addition,, although used some specific terms in this description, these terms just for convenience of description, do not form any restriction to the present invention.