CN111956761A

CN111956761A - Traditional Chinese medicine formula for increasing white blood cells and improving immunity, decocting method and eating method

Info

Publication number: CN111956761A
Application number: CN202011031935.8A
Authority: CN
Inventors: 罗海生
Original assignee: Dongguan Qihua Biotechnology Co ltd
Current assignee: Dongguan Qihua Biotechnology Co ltd
Priority date: 2020-09-27
Filing date: 2020-09-27
Publication date: 2020-11-20

Abstract

The invention discloses a traditional Chinese medicine formula for increasing leucocytes and improving immunity, which comprises the following components in parts by weight: 15-35 parts of radix angelicae; 10-30 parts of fingered citron; 40-60 parts of sea buckthorn; 10-30 parts of kudzu roots; 20-40 parts of fructus amomi; 20-40 parts of rhizoma polygonati; 5-25 parts of liquorice; 20-40 parts of mother medicine. The invention also discloses a decocting method and an eating method based on the traditional Chinese medicine formula. The invention can obviously increase white blood cells and platelets, improve immunity, improve symptoms of low white blood cells and platelets and the like caused by radiotherapy and chemotherapy, has no side effect, and promotes various immune cells to grow towards a healthy direction.

Description

Traditional Chinese medicine formula for increasing white blood cells and improving immunity, decocting method and eating method

Technical Field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine formula for increasing leucocytes and improving immunity, a decocting method and an eating method.

Background

Cancer is one of the main diseases threatening human life, and the treatment of cancer still mainly comprises surgery, radiotherapy and chemotherapy at present. The obvious side effect of the chemotherapy and the radiation therapy which are used as main treatment means is that the hematopoietic function of bone marrow is inhibited, so that leucopenia is caused, the treatment process and the treatment effect of a patient are influenced, the disease resistance of the patient is reduced, and the patient is easy to be infected with a series of complications such as other diseases. The serious reduction of leucocytes in the chemotherapy causes alopecia, difficult diet, weak body and serious influence on resistance, which is the defect of the modern medicine in treating the cancer.

Clinically, the white blood cell count in the peripheral hemogram is lower than 4000/mm²The normal proportion of neutrophils is called leukopenia. According to clinical preliminary statistics, the leucopenia caused by radiotherapy is about 5% (the irradiation dose is a conventional dose), while the leucopenia caused by chemotherapy has larger variation, and the leucopenia rate is about 40-70% (calculated according to a treatment course). In order to effectively reduce the incidence rate of the disease and prevent the disease, some medicines for increasing the white blood cells are usually taken while chemotherapy and radiotherapy, at present, western medicines are generally adopted, and although the western medicines have a certain treatment effect, the western medicines generally have the defects of certain side effect, high treatment cost and slow effect, so the using effect is not ideal. Therefore, how to screen the drugs which can effectively increase the leucocytes and improve the immunity from the traditional Chinese medicines is a critical urgency in the clinical application at present.

Disclosure of Invention

In view of the above disadvantages, the present invention aims to provide a traditional Chinese medicine formula, decoction and eating method for increasing leukocytes and enhancing immunity, which can significantly increase leukocytes and platelets, enhance immunity, improve the symptoms of leukocyte and platelet depletion caused by radiotherapy and chemotherapy, have no side effects, and promote the growth of various immune cells in a healthy direction.

The technical scheme adopted by the invention to achieve the aim is as follows:

the traditional Chinese medicine formula for increasing white blood cells and improving immunity is characterized by comprising the following components in parts by weight:

15-35 parts of radix angelicae;

10-30 parts of fingered citron;

40-60 parts of sea buckthorn;

10-30 parts of kudzu roots;

20-40 parts of fructus amomi;

20-40 parts of rhizoma polygonati;

5-25 parts of liquorice;

20-40 parts of mother medicine.

As a further improvement of the invention, the paint comprises the following components in parts by weight:

25 parts of radix angelicae;

20 parts of fingered citron;

50 parts of sea buckthorn;

20 parts of kudzu root;

30 parts of fructus amomi;

30 parts of rhizoma polygonati;

15 parts of liquorice;

30 parts of mother medicine.

As a further improvement of the invention, the mother medicine is ginsenoside.

The decocting method based on the traditional Chinese medicine formula is characterized by comprising the following steps:

(1) preparing raw materials according to a ratio, and packaging into a tea bag;

(2) putting 10-20 tea bags into a tile pot, adding purified water and 15-25g ginger slices, and adding 400-600ml of purified water into every 60-120g of tea bags;

(3) boiling with strong fire, and decocting with slow fire for 10-20 min;

(4) adding 80-120g cleaned rabbit meat, boiling with strong fire, and cooking with slow fire.

The eating method of the traditional Chinese medicine obtained by the decoction method is characterized in that the traditional Chinese medicine is taken once in the morning and at night and is eaten 0.5 to 1.5 hours after meal.

As a further improvement of the invention, after the first soup is drunk in the morning and the rabbit meat is eaten, the remaining tea bag is added with 1200 and 1500ml of water and is returned to the pot for the second time to be drunk as the tea water of the same day.

The invention has the beneficial effects that:

(1) the traditional Chinese medicine in the formula is prepared by combining radix angelicae, fingered citron, sea buckthorn, radix puerariae, fructus amomi, rhizoma polygonati and liquorice in a special proportion, so that the two symptoms of spleen-kidney deficiency and blood stasis are conditioned and treated; meanwhile, the ginsenoside used as the parent drug promotes the generation of leucocytes, so the medicine is particularly suitable for treating the leucopenia caused by cancer radiotherapy and chemotherapy, and can also be used for treating the leucopenia with unknown reasons and people with low immunity.

(2) In the chemotherapy treatment process, when the traditional Chinese medicine is taken for treatment, the white blood cells and the platelets are obviously increased and finally reach the normal range, the symptoms of low white blood cells and platelets and the like caused by radiotherapy and chemotherapy are obviously improved, no side effect is caused, and the growth of various immune cells in a healthy direction is promoted.

(3) The traditional Chinese medicine in the formula also has the effects of stimulating appetite, expelling toxin, promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, enhancing immunity, obviously improving the symptoms of low white blood cells and platelets, physical performance reduction, sore throat, oral ulcer, constipation, poor sleep, hair loss and the like caused by radiotherapy and chemotherapy, and promoting the growth of various immune cells in a healthy direction.

The above is an overview of the technical solutions of the present invention, and the present invention is further described below with reference to the accompanying drawings and the detailed description thereof.

Drawings

FIG. 1 is a report of a cytological diagnosis of bone marrow at 12 months and 28 days 2018;

FIG. 2 is a report of a cytological examination of bone marrow at 1 month and 2 days 2019;

FIG. 3 is a 2019, month 2 and day 11 examination report;

FIG. 4 is a 2019, month 3 and day 11 inspection report;

FIG. 5 is a 2019 inspection report of 4, 16;

FIG. 6 is a bone marrow image report of 24 days 5 months 2019;

FIG. 7 is a report sheet of the flow cytometric immunofluorescence analysis results of 24 days at 5 months in 2019;

FIG. 8 is a 2019 examination report of 5, 28;

fig. 9 is a test report sheet of 2019, 6, month and 4.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined purposes, the following detailed description of the embodiments of the present invention is provided with the accompanying drawings and the preferred embodiments.

The first embodiment is as follows:

the embodiment provides a traditional Chinese medicine formula for increasing white blood cells and improving immunity, which comprises the following components in parts by weight:

15 parts of radix angelicae;

10 parts of fingered citron;

40 parts of sea buckthorn;

10 parts of kudzu roots;

20 parts of fructus amomi;

20 parts of rhizoma polygonati;

5 parts of liquorice;

20 parts of mother medicine.

Example two:

35 parts of radix angelicae;

30 parts of fingered citron;

60 parts of sea buckthorn;

30 parts of kudzu roots;

40 parts of fructus amomi;

40 parts of rhizoma polygonati;

25 parts of liquorice;

40 parts of mother medicine.

Example three:

25 parts of radix angelicae;

20 parts of fingered citron;

50 parts of sea buckthorn;

20 parts of kudzu root;

30 parts of fructus amomi;

30 parts of rhizoma polygonati;

15 parts of liquorice;

30 parts of mother medicine.

The effects of the components in the first to third embodiments are described in detail below:

radix angelicae: dispelling pathogenic wind, eliminating dampness, relieving swelling and pain; it can be used for treating headache, supercilium pain, odontalgia, nasosinusitis, cold-dampness, abdominal pain, intestinal wind, hemorrhoid, leucorrhea with red and white discharge, carbuncle, skin ulcer, pruritus, scabies, and tinea.

Fingered citron: the root, stem, leaf, flower and fruit can be used as the medicine, and are pungent, bitter, sweet, warm and nontoxic; it has the functions of regulating qi, eliminating phlegm, stopping vomiting, relieving flatulence, soothing liver, strengthening spleen, regulating stomach and other medicinal functions. Has obvious relieving effect on tracheitis and asthma of the old; has more obvious curative effect on dyspepsia and chest and abdomen swelling and stuffiness of general people. The fingered citron can be prepared into various traditional Chinese medicinal materials, and has the effects of health care and life prolonging after long-term administration.

Sea-buckthorn: the sea-buckthorn fruit is rich in nutrition, and active substances such as various vitamins, fatty acids, trace elements, linolein, sea-buckthorn flavone, superoxide and the like and various amino acids required by a human body are determined to be contained in the sea-buckthorn fruit. The folium Hippophae can be used for preparing health tea.

The seabuckthorn oil contains 206 active substances beneficial to human bodies, wherein 46 bioactive substances comprise a large amount of vitamin E, vitamin A, flavone and the like, has special pharmacological properties of resisting fatigue, enhancing organism vitality, resisting cancer and the like, has the effects of protecting and accelerating the repair of gastric mucosa, increasing the drug property of intestinal bifidobacteria, reducing plasma cholesterol and reducing the content of cholesterol in blood vessel walls, can prevent and treat hyperlipidemia and atherosclerosis, and has the effect of promoting wound healing.

Kudzu root: can be used for treating fever due to exterior syndrome, pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency.

And (3) husky kernels: has effects in eliminating dampness, activating spleen, promoting qi circulation, regulating stomach function, and promoting digestion.

Rhizoma polygonati: has effects in invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney.

Licorice root:

(1) licorice root is indicated for heart-qi deficiency, palpitation, intermittent pulse, spleen-stomach qi deficiency, lassitude and hypodynamia. The former is often combined with Gui Zhi, such as Gui Zhi gan Cao Tang and gan Cao Zhi Tang; the latter is often combined with Dang Shen and Bai Zhu, such as Sijun Zi Tang and Lian Zhong Wan.

(2) Licorice root is used for abscess, sores and ulcers, swollen and sore throat, etc. It can be used singly, orally or externally, or combined. For abscess, deep-rooted carbuncle, sores and ulcers, it is often combined with jin Yin Hua and Lian Qiao to play the role of clearing heat and removing toxicity, such as Xian Fang Huo Ming Yin. For swollen and sore throat, it is often combined with Jie Geng, such as Jie Geng Tang. For intoxication by pesticide and food, it is often combined with mung bean or decocted with Fang Feng water for oral administration.

(3) Radix Glycyrrhizae can be used for treating asthma and cough. It can be used singly or combined with other herbs. For example, ERCHEN decoction for treating cough due to damp phlegm; ling gan Wu Wei Jiang Xin Tang for treating cough and asthma due to cold-phlegm; mulberry and apricot decoction for treating cough due to dry phlegm; radix Platycodi decoction for treating lung abscess, coughing up saliva, stinking up and purulent phlegm due to heat-toxin; and licorice dry ginger decoction for treating cough, spittle and sialorrhea. It is also often combined with wind-heat cough, wind-cold cough and heat-phlegm cough.

(4) Licorice root, radix Glycyrrhizae is used for stomachache, abdominal pain, acute contracture pain of gastrocnemius and the like, and is often used together with Paeonia lactiflora pall, which can significantly enhance the curative effect of treating acute contracture pain, such as Paeonia lactiflora and Licorice root decoction.

(5) Licorice root, radix Glycyrrhizae is used to harmonize the intensity of some drugs. For example, the flavoring Chengqi decoction can alleviate the purgative effect of Da Huang and Mang Xiao and the irritation to the gastrointestinal tract. In addition, it is commonly used in many prescriptions to coordinate the actions of the drugs.

(6) Licorice root has the similar effect of adrenocortical hormone. Has inhibitory effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine.

(7) Licorice root has the similar effect of adrenocortical hormone. Has inhibitory effect on hyperacidity caused by histamine; it also has antacid and spasmodic effects on smooth muscle of stomach and intestine.

(8) Licoflavone, glycyrrhiza extract and glycyrrhetinic acid have obvious cough relieving effect; the phlegm eliminating effect is also obvious, and the action strength is glycyrrhizic acid, licoflavone and liquorice extract.

(9) The Glycyrrhrizae radix has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa. The glycyrrhiza extract and glycyrrhizic acid have detoxifying effect similar to that of glucuronic acid on certain toxicants.

(10) Licorice is commonly used to treat symptoms accompanying menopause because it contains liquiritigenin, a hormone-like compound that helps to balance the hormone content in women.

(11) The hypochlorous acid contained in Glycyrrhrizae radix can block carcinogen from inducing tumor growth.

In the first to third embodiments, the mother drug is ginsenoside.

Specifically, the ginsenoside has the following effects:

(1) ginsenoside Rh2 in ginsenoside has the function of promoting the generation of leucocyte, and specifically stimulates macrophage in hematopoietic induction microenvironment through a direct or indirect way, so that the synthesis and secretion of hematopoietic regulatory factors are promoted from the level of protein and the level of gene transcription, and the proliferation and differentiation of hematopoietic progenitor cells of various lines are further promoted, thereby being one of ways of regulating the generation of leucocyte by ginsenoside. Therefore, the ginsenoside can rapidly improve the white blood cells and reduce the pain of patients.

(2) Has the function of improving the immunity of the organism;

(3) can effectively regulate the functions of the nervous system of the human body and has the effect of soothing the nerves;

(4) can effectively protect the cardiovascular and cerebrovascular vessels and improve the cardiac function;

(5) has antitumor effect, and can improve immunity, regulate body functions, and resist cancer cells.

(6) Has antifatigue effect;

(7) can regulate arrhythmia, promote salivation, tranquilize mind, regulate arrhythmia, and protect heart function.

The traditional Chinese medicine prepared by mixing the components according to the proportion has the following effects: promoting appetite, removing toxic substances, promoting blood circulation for removing blood stasis, softening and resolving hard mass, enhancing immunity, remarkably improving symptoms caused by radiotherapy and chemotherapy such as leucocyte and platelet deficiency, physical ability decline, sore throat, oral ulcer, constipation, poor sleep and hair loss, and promoting growth of various immunocytes to a healthy direction. Particularly, in the chemotherapy treatment process of patients, the number of the white blood cells of the patients can be restored to a normal value by taking the formula without injecting a white blood-raising needle to increase the number of the white blood cells, and the formula is mainly suitable for the patients with the white blood cells lower than the normal value.

The specific treatment mechanism is as follows: deficiency of the essence (i.e., spleen and kidney deficiency) is the root cause of leukopenia, "spleen is the acquired essence", the source of qi and blood generation and transformation, the five zang-organs and six fu-organs rely on nourishing, and if spleen deficiency and qi and blood are not generated, blood deficiency is caused; the kidney is the congenital origin, which is mainly the bone to produce marrow and is stored by the essence of the five zang-organs and six fu-organs, and the marrow sea is not filled if the kidney qi is insufficient, and the generation of qi and blood is also affected when the essence and blood are homologous. The dysfunction of spleen in transporting and transforming food essence can lead to kidney qi deficiency; on the contrary, kidney yang deficiency can not warm spleen yang, and both affect each other, resulting in spleen-kidney deficiency and insufficiency of nutrient-defensive qi and blood. In addition, invasion by toxic heat and blood stasis are also important causes of the disease. The pathogenic heat-toxicity (radiotherapy and chemotherapy) invades the body and the nutrient-yin is robbed. Most patients are manifested as deficiency of both qi and yin, while a few are accompanied by blood heat; according to the traditional understanding of 'blood stasis is needed after long-term illness' in traditional Chinese medicine, patients with leucopenia are not cured for a long time, and clinical symptoms of blood stasis appear in the past. In conclusion, the etiology is not limited to internal injury and external infection, and the pathogenesis is not limited to congenital and acquired two factors. The innate key is the kidneys and the acquired key is the spleen.

Therefore, the traditional Chinese medicine is prepared by combining radix angelicae, fingered citron, sea buckthorn, radix puerariae, fructus amomi, rhizoma polygonati and liquorice in a special proportion, and is used for conditioning and treating spleen-kidney deficiency and blood stasis; meanwhile, the generation of leucocytes is promoted by the ginsenoside, particularly the ginsenoside rh2, which is used as a mother medicine, so that the problems of bone marrow suppression and leucocyte reduction caused by side effects of chemotherapy and radiotherapy are solved, and no side effect is caused.

Example four:

the embodiment provides a decocting method based on any one of the first to third embodiments of the traditional Chinese medicine formula, which comprises the following steps:

(1) preparing raw materials according to a ratio, and packaging into a tea bag;

(2) putting 10-20 tea bags into a tile pot (according to different usage amounts of personal physical conditions), adding purified water and 15-25g ginger slices, about 2 ginger slices, and adding 400 ml of purified water and 600ml of purified water per 60-120g of tea bags, preferably 500ml of purified water;

(3) boiling with strong fire, and decocting with slow fire for 10-20 min, preferably for 10 min;

(4) adding cleaned rabbit meat 80-120g, preferably 100g, and cooking with strong fire, then cooking with slow fire, and taking. When the product is taken, oil is not required to be discharged, and a little salt is added for seasoning.

The rabbit meat with leukopenia is a high protein, low fat and low cholesterol meat food, and can be used for strengthening body constitution without obesity.

Example five:

the embodiment provides an eating method of the traditional Chinese medicine obtained by implementing the decoction method, which is characterized in that the traditional Chinese medicine is taken once in the morning and at night, and is eaten 0.5-1.5 hours after meal, and is optimally eaten 1 hour after meal.

After the first soup is drunk in the morning and rabbit meat is eaten, the remaining tea bags are added with 1200 and 1500ml of water and then are boiled for the second time, and preferably 1500ml of water is added to be used as the tea for the same day.

When eating, it is recommended to eat the rabbit meat together with the rabbit meat. At the beginning of eating, each person has different physical conditions and different conditioning reactions occur, such as: large flatus; the excrement is discharged for two or three days, the excrement is soft and thin, the excrement is discharged for 2-4 times every day, and the color of the excrement is slowly recovered to be normal later; individuals have a sense of tiredness with a slight sore throat (like getting inflamed), discomfort with a slight stomach distention or pain, more urine, and a desire to sleep; there are also situations where an individual is in a state of excessive excitement and poor sleep at night. These reactions generally occur more in the first week, less in the second week, and essentially none after half a month, and are normal when one sticks to two meals per day, except two bowls of soup, and the best is to keep about 8 cups of double-leaved tea.

During the chemotherapy treatment process of a patient, white blood cells and platelets are obviously increased by taking the traditional Chinese medicine formula provided by the embodiment of the invention for treatment. Specific treatment data and test report data are as follows:

certain Chen starts to continuously burn for a plurality of days in 12 months in 2018, and then goes to hospitals in Yangxi, Zhanjiang, Guangzhou and the like for examination, and the diagnosis report is shown in fig. 1 and 2 from the beginning of abnormal routine blood examination to the end of diagnosis of acute myeloid leukemia.

The chemotherapy starts to be performed in 2019 month 1, the traditional Chinese medicine with the formula provided by the invention is eaten, each course of treatment is treated by a chemotherapy needle for ten days, the minimum leukocyte is 0.3 x 10^9/L, the minimum platelet is 2 x 10^9/L, and when the traditional Chinese medicine is drunk by a user all the time in the chemotherapy period, the leukocyte and the platelet which are seriously low are improved.

The test report of 1 month and 14 days in 2019 shows that the white blood cells are 0.3 x 10^9/L and the platelets are 13 x 10^ 9/L.

The examination report of 11/2/2019 shows that the white blood cells are 0.6 x 10^9/L and the platelets are 2 x 10^9/L, and the examination report is shown in FIG. 3.

The examination report of 3, 11 and 2019 shows that the white blood cells are 5.4X 10^9/L and the platelets are 335X 10^9/L, and the examination report is shown in FIG. 4.

The examination report of 2019, 4, 16 and shows that the white blood cells are 4.4 x 10^9/L and the platelets are 185 x 10^9/L, and the examination report is shown in FIG. 5.

A bone marrow puncture report of 24 days at 5 months in 2019, and a bone marrow image report is shown in fig. 6.

The flow cytometric immunofluorescence analysis report of 24 days in 2019, 5 months, and the analysis result report is shown in fig. 7.

The examination report of 5/28/2019 shows that the white blood cells are 4.2X 10^9/L and the platelets are 222X 10^9/L, and the examination report is shown in FIG. 8.

The blood examination report of 6/4/2019 shows that the white blood cells are 5.8 x 10^9/L, the platelets are 193 x 10^9/L, and the examination report is shown in FIG. 9.

If a certain old patient is visited in 6 months and 3 days in 2019, the patient's condition is more ideal.

The results of bone marrow puncture report of 7, 3 and 2019 are ideal.

The flow cytometric immunofluorescence analysis of 7, 3 and 2019 shows ideal report results.

Today (7 months in 2020) one year after a certain case (7 months in 2019) is released last time, the patient insists on eating the traditional Chinese medicine without changing bone marrow, the treatment cost in a hospital is not more than 10 ten thousand, and a plurality of doctors give a prediction of 'only 13-month survival time' when the preliminary diagnosis is overturned (12 months in 2018).

As can be seen from the above detection reports, when the patient takes the traditional Chinese medicine of the embodiment of the invention for treatment in the chemotherapy treatment process, the white blood cells and the platelets are obviously increased and finally reach the normal range. Therefore, the traditional Chinese medicine formula disclosed by the embodiment can promote the generation of white blood cells, obviously improve the symptoms of low white blood cells and platelets and the like caused by radiotherapy and chemotherapy, and promote the growth of various immune cells in a healthy direction.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the technical scope of the present invention, so that other structures obtained by using the same or similar technical features as the above-described embodiments of the present invention are within the protection scope of the present invention.

Claims

1. The traditional Chinese medicine formula for increasing white blood cells and improving immunity is characterized by comprising the following components in parts by weight:

2. the traditional Chinese medicine formula for increasing leukocytes and improving immunity according to claim 1, is characterized by comprising the following components in parts by weight:

3. the traditional Chinese medicine formula for increasing leukocytes and improving immunity according to claim 1, wherein the parent drug is ginsenoside.

4. The decocting method based on the traditional Chinese medicine formula of any one of claims 1 to 3, which is characterized by comprising the following steps:

(1) preparing raw materials according to a ratio, and packaging into a tea bag;

(3) boiling with strong fire, and decocting with slow fire for 10-20 min;

5. The eating method of the traditional Chinese medicine obtained by the decoction method of claim 4 is implemented, wherein the traditional Chinese medicine is taken once in the morning and at night, and is eaten 0.5-1.5 hours after meals.

6. The eating method of the traditional Chinese medicine as claimed in claim 5, wherein the first soup is drunk in the morning, the rabbit meat is eaten, the remaining tea bag is added with 1200 and 1500ml of water and then boiled for the second time, and the tea water is drunk in the same day.