CN107569648B - A kind of preparation method of Chinese eaglewood medicated leaven - Google Patents
A kind of preparation method of Chinese eaglewood medicated leaven Download PDFInfo
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Abstract
The present invention relates to pharmaceutical fields, disclose a kind of preparation method of Chinese eaglewood medicated leaven, including：1）Weighing；2）Sterilizing；3）Batch mixing；4）Flour slurry processed；5）Softwood processed；6）Briquetting；7）It is dry；8）Packaging.Chinese eaglewood medicated leaven made from the method for the present invention other than it can be used as the bulk pharmaceutical chemicals of other drugs, can also directly be taken in bulk.And it is easy to be absorbed by alimentary canal after taking, it is rapid-action.
Description
Technical field
The present invention relates to pharmaceutical field more particularly to a kind of preparation methods of Chinese eaglewood medicated leaven.
Background technology
The effect of Chinese eaglewood medicated leaven has thin tableization stagnant, soothing liver and harmonizing stomach can be used in treatment table heresy not to the greatest extent, and stagnation of liver-QI and stomach-QI is uncomfortable in chest
Gastral cavity is swollen, side of body rib is had a pain, acid regurgitation vomiting.Chinese eaglewood medicated leaven can be used as the bulk pharmaceutical chemicals of other drugs, also can directly take.But existing work
Chinese eaglewood medicated leaven made from skill has that dissolving is slow in human body alimentary canal, is not easy to absorb when directly taking.
Number of patent application is that the Chinese patent of CN201610708316.5 discloses Chinese eaglewood medicated leaven biologic ferment preparation, is prepared
Method is：Brown sugar is poured into water stirring and melts, then radix rehmanniae preparata, cape jasmine, Cortex Magnoliae Officinalis, dragon fruit, Fructus Aurantii, malt, snake gall, fig are soaked
Then ferment 1 year or more among syrup puts down pine tree juice, rice vinegar secondary fermentation four months or more, the temperature of fermentation again
32 ~ 38 DEG C, pH value 6.0, during which pay attention to it is ventilated, avoid sunlight；Fermentation is completed, and finally presses 8 with Chinese eaglewood medicated leaven:2 ratio is mixed
It closes and Chinese eaglewood medicated leaven biologic ferment preparation is made；The invention promotes enzyme metabolic system by enzyme microb, makes estradiol and estradiol
Secretion balance, fundamentally solves the problems, such as acne, and have no toxic side effect.
But above-mentioned patent is compounded with other drugs again and again to prepare biologic ferment using Chinese eaglewood medicated leaven as raw material
Preparation is not directed to the preparation method of Chinese eaglewood medicated leaven itself, simultaneously because it is the bulk pharmaceutical chemicals as other medicines, therefore also not
Have and solves technical problem described previously.
Invention content
In order to solve the above technical problem, the present invention provides a kind of preparation methods of Chinese eaglewood medicated leaven.The method of the present invention is made
Chinese eaglewood medicated leaven, in bulk, other than it can be used as the bulk pharmaceutical chemicals of other drugs, can also directly take.And it is easy after taking
It is absorbed by alimentary canal, it is rapid-action.
The specific technical solution of the present invention is：A kind of preparation method of Chinese eaglewood medicated leaven, includes the following steps：
1）Weighing：Weigh respectively agalloch eaglewood, root of Aucklandia lappa Decne, radix bupleuri, ginger Cortex Magnoliae Officinalis, cardamom, fructus amomi, Radix Curcumae, windproof, pueraria lobata, the root of three-nerved spicebush,
Fructus Aurantii, dried orange peel, campanulaceae, betel nut, frying malt, frying rice sprout, the root of purple-flowered peucedanum, bran fried green skin, the root of Dahurain angelica, santal, dalbergia wood, Rhizoma Et Radix Notopterygii, wrinkled giant hyssop
With Radix Glycyrrhizae totally 24 taste bulk pharmaceutical chemicals
2）Sterilizing：It sterilizes respectively to the bulk pharmaceutical chemicals.
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, are then mixed.
4）Flour slurry processed：Flour and purified water are mixed into paste, be then then added to by boiling purified water at a simmer into
Row stirring, stirring to slurry color and luster it is gentle after, be made flour slurry.
5）Softwood processed：Mixed bulk pharmaceutical chemicals are added in mixing machine, flour slurry is slowly added into, stir 5-10min, system
At the softwood uniformly without agglomerate, then softwood is taken to be placed in oscillating granulator, carry out whole grain, wet grain is made.
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made.
7）It is dry：Wet knee-piece is dried, dry medium block is made.
8）Packaging：After being packed to dry medium block, finished product.
24 taste medicine of the present invention couple sterilizes before batch mixing, is milled, and strictly controls bulk pharmaceutical chemicals in softwood and starched with flour
Amount ratio so that Bulk drug obtained take after be easy is absorbed by alimentary canal, so as to fast onset.
Preferably, step 1）In, the parts by weight of each bulk pharmaceutical chemicals are：18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, Jiang Zhihou
9 parts of Piao, 9 parts of cardamom, 9 parts of fructus amomi, 9 parts of Radix Curcumae, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, tangerine
36 parts of stalk, 36 parts of betel nut, 36 parts of frying malt, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, santal
13.5 parts of 27 parts, 27 parts of dalbergia wood, 27 parts of Rhizoma Et Radix Notopterygii, 27 parts of wrinkled giant hyssop and Radix Glycyrrhizae.
Preferably, step 2）In, sterilizing specific method is：Bulk pharmaceutical chemicals are set in sterilizing installation, are kept the temperature at 55-75 DEG C
Sterilize at least 2h, is then evacuated to 0.07MPa or more, sprays into the ethyl alcohol of suitable a concentration of 88-92%, natural cooling is at least
12h, handling material are spare.
Preferably, step 3）In, 80-120 mesh sieve is smashed it through, bulk pharmaceutical chemicals are then added to three-dimensional movement mixer
Middle mixing 25-35min.
Raw material will be under the granularity, it is easier to be absorbed by alimentary canal.
Preferably, step 4）In, the mass ratio of flour and purified water is 37-38:120.
Preferably, step 5）In, the mass ratio of bulk pharmaceutical chemicals and flour slurry is 3.5-4.5:1.
Preferably, step 5）In, before bulk pharmaceutical chemicals are mixed with flour slurry, coral powder, the coral are added into bulk pharmaceutical chemicals
The quality of coral powder is the 1-5% of bulk pharmaceutical chemicals.
Preferably, the coral powder passes through pretreatment, specially：It takes coral and it is eluted with water, pulverized
After 20-80 mesh sieve, pickling is carried out to coral powder surface with the hydrochloric acid solution of 1-5wt%, 200-400 mesh was regrind after pickling
Sieve first roasts 1-3h to coral powder at 200-300 DEG C under nitrogen protection, is then warming up to 900-950 DEG C and continues to roast 1-
2h takes out, 18-22 in mass ratio:1 itself and lecithin are mixed, and packet oil film is carried out to coral powder surface after roasting, are made
Pretreated coral powder.
In order to further increase after drug administration in gastral dissolved efficiency and absorptivity, starched in bulk pharmaceutical chemicals and flour
Before mixing, coral powder is added into bulk pharmaceutical chemicals, coral is the shell that coral polyp secrets out of, and the chemical composition of coral matrix is mainly
Calcium carbonate exists with crystallite calcite aggregated form, and certain organic matter is also contaminated in the matrix.Coral matrix quality
Loose porous, organic matter is embedding to be invested in hole.The present invention pre-processes it, after being first coarsely ground into powder, carries out pickling, effect is
Its Surface of Coral is removed to be difficult to, by washing the impurity removed, its internal hole " can be got through " after removing impurity, after being convenient for
Continuous calcining.In 200-300 DEG C of low temperature calcination, it is therefore an objective to remove the organic matter in matrix, the specific surface area of coral is made to increase；
In 900-950 DEG C of high-temperature calcination, it is therefore an objective to which it is calcium oxide and carbon dioxide to make calcium carbonate pyrolysis, which is：On the one hand,
Calcium carbonate can further increase its porosity when sloughing gas；On the other hand, after generating calcium oxide, calcium oxide activity is more
Height, into alimentary canal after can react with hydrochloric acid in gastric juice liquid, moisture, and discharge heat so that medicine disintegration realizes each bulk pharmaceutical chemicals
It is quick dissolving, release and be fully absorbed.And its specific surface area bigger after pre-processing, reactivity higher, effect are more preferable.
It should be noted that when coral powder and flour starch batch mixing, it is dissolved in absorption and reacts in advance, for this purpose, the present invention is specially mixed
It uses lecithin to carry out surface packet oil film before material to it, it is prevented to be contacted and premature wear with water.Above-mentioned material is natural original
Material, securely and reliably.
Preferably, step 7）In, drying temperature is 50-70 DEG C, drying time 26-34h, and moisture control is 5% after drying
Below.
It is compared with the prior art, the beneficial effects of the invention are as follows：Chinese eaglewood medicated leaven made from the method for the present invention is in bulk, in addition to
Except can be as the bulk pharmaceutical chemicals of other drugs, can also directly it take.And it is easy to be absorbed by alimentary canal after taking, it is rapid-action.
Specific implementation mode
With reference to embodiment, the invention will be further described.
Embodiment 1
A kind of preparation method of Chinese eaglewood medicated leaven, it is characterised in that include the following steps：
1）Weighing：Weigh respectively 18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, 9 parts of ginger Cortex Magnoliae Officinalis, 9 parts of cardamom, 9 parts of fructus amomi,
9 parts of Radix Curcumae, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, 36 parts of campanulaceae, 36 parts of betel nut, frying wheat
36 parts of bud, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, 27 parts of santal, 27 parts of dalbergia wood, Rhizoma Et Radix Notopterygii 27
13.5 parts of part, 27 parts of wrinkled giant hyssop and Radix Glycyrrhizae.
2）Sterilizing：Bulk pharmaceutical chemicals are set in sterilizing installation, insulated sterilizing at least 2h, is then evacuated at 65 DEG C
0.07MPa or more, suitable a concentration of 90% ethyl alcohol of penetrating, natural cooling at least 12h, handling material are spare.
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, are sieved with 100 mesh sieve, bulk pharmaceutical chemicals are then added to three-dimensional movement mixing
30min is mixed in machine.Then it mixes.
4）Flour slurry processed：Flour and purified water are mixed into paste, be then then added to by boiling purified water at a simmer into
Row stirring, stirring to slurry color and luster it is gentle after, be made flour slurry.Flour and the mass ratio of purified water are 37.5:120.
5）Softwood processed：Mixed bulk pharmaceutical chemicals are added in mixing machine, flour slurry is slowly added into, stirs 8min, be made
The uniformly softwood without agglomerate；The mass ratio of bulk pharmaceutical chemicals and flour slurry is 4:1.Then softwood is taken to be placed in oscillating granulator, into
Wet grain is made in row whole grain.
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made.
7）It is dry：Wet knee-piece is dried, drying temperature is 60 DEG C, drying time 30h, and moisture control is 5% after drying
Hereinafter, dry medium block is made.
8）Packaging：After being packed to dry medium block, finished product.
Embodiment 2
A kind of preparation method of Chinese eaglewood medicated leaven, it is characterised in that include the following steps：
1）Weighing：Weigh respectively 18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, 9 parts of ginger Cortex Magnoliae Officinalis, 9 parts of cardamom, 9 parts of fructus amomi,
9 parts of Radix Curcumae, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, 36 parts of campanulaceae, 36 parts of betel nut, frying wheat
36 parts of bud, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, 27 parts of santal, 27 parts of dalbergia wood, Rhizoma Et Radix Notopterygii 27
13.5 parts of part, 27 parts of wrinkled giant hyssop and Radix Glycyrrhizae.
2）Sterilizing：Bulk pharmaceutical chemicals are set in sterilizing installation, insulated sterilizing at least 2h, is then evacuated at 55 DEG C
0.07MPa or more, suitable a concentration of 88% ethyl alcohol of penetrating, natural cooling at least 12h, handling material are spare.
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, 80 mesh sieve is crossed, bulk pharmaceutical chemicals is then added to three-dimensional movement mixer
Middle mixing 35min.Then it mixes.
4）Flour slurry processed：Flour and purified water are mixed into paste, be then then added to by boiling purified water at a simmer into
Row stirring, stirring to slurry color and luster it is gentle after, be made flour slurry.Flour and the mass ratio of purified water are 37:120.
5）Softwood processed：Mixed bulk pharmaceutical chemicals are added in mixing machine, flour slurry is slowly added into, stirs 5min, be made
The uniformly softwood without agglomerate；The mass ratio of bulk pharmaceutical chemicals and flour slurry is 3.5:1.Then softwood is taken to be placed in oscillating granulator,
Whole grain is carried out, wet grain is made.
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made.
7）It is dry：Wet knee-piece is dried, drying temperature is 50 DEG C, drying time 34h, and moisture control is 5% after drying
Hereinafter, dry medium block is made.
8）Packaging：After being packed to dry medium block, finished product.
Embodiment 3
A kind of preparation method of Chinese eaglewood medicated leaven, it is characterised in that include the following steps：
1）Weighing：Weigh respectively 18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, 9 parts of ginger Cortex Magnoliae Officinalis, 9 parts of cardamom, 9 parts of fructus amomi,
9 parts of Radix Curcumae, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, 36 parts of campanulaceae, 36 parts of betel nut, frying wheat
36 parts of bud, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, 27 parts of santal, 27 parts of dalbergia wood, Rhizoma Et Radix Notopterygii 27
13.5 parts of part, 27 parts of wrinkled giant hyssop and Radix Glycyrrhizae.
2）Sterilizing：Bulk pharmaceutical chemicals are set in sterilizing installation, insulated sterilizing at least 2h, is then evacuated at 65 DEG C
0.07MPa or more, suitable a concentration of 90% ethyl alcohol of penetrating, natural cooling at least 12h, handling material are spare.
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, are sieved with 100 mesh sieve, bulk pharmaceutical chemicals are then added to three-dimensional movement mixing
30min is mixed in machine.Then it mixes.
4）Flour slurry processed：Flour and purified water are mixed into paste, be then then added to by boiling purified water at a simmer into
Row stirring, stirring to slurry color and luster it is gentle after, be made flour slurry.Flour and the mass ratio of purified water are 37.5:120.
5）Softwood processed：The coral powder that bulk pharmaceutical chemicals gross mass 3% is added into bulk pharmaceutical chemicals, mixed bulk pharmaceutical chemicals are added to
In mixing machine, it is slowly added into flour slurry, 8min is stirred, the uniformly softwood without agglomerate is made；The mass ratio of bulk pharmaceutical chemicals and flour slurry
It is 4:1.Then it takes softwood to be placed in oscillating granulator, carries out whole grain, wet grain is made.
The coral powder is by pretreatment, specially：It takes coral and it is eluted with water, after 50 mesh of pulverizing sieve,
Pickling is carried out to coral powder surface with the hydrochloric acid solution of 3wt%, 300 mesh sieve was regrind after pickling, it is under nitrogen protection, right
Coral powder first roasts 2h at 250 DEG C, is then warming up to 910 DEG C and continues to roast 1.5h, takes out, in mass ratio 20:1 by itself and ovum
Phosphatide is mixed, and packet oil film is carried out to coral powder surface after roasting, and pretreated coral powder is made.
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made.
7）It is dry：Wet knee-piece is dried, drying temperature is 60 DEG C, drying time 30h, and moisture control is 5% after drying
Hereinafter, dry medium block is made.
8）Packaging：After being packed to dry medium block, finished product.
Embodiment 4,
A kind of preparation method of Chinese eaglewood medicated leaven, it is characterised in that include the following steps：
1）Weighing：Weigh respectively 18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, 9 parts of ginger Cortex Magnoliae Officinalis, 9 parts of cardamom, 9 parts of fructus amomi,
9 parts of Radix Curcumae, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, 36 parts of campanulaceae, 36 parts of betel nut, frying wheat
36 parts of bud, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, 27 parts of santal, 27 parts of dalbergia wood, Rhizoma Et Radix Notopterygii 27
13.5 parts of part, 27 parts of wrinkled giant hyssop and Radix Glycyrrhizae.
2）Sterilizing：Bulk pharmaceutical chemicals are set in sterilizing installation, insulated sterilizing at least 2h, is then evacuated at 75 DEG C
0.07MPa or more, suitable a concentration of 92% ethyl alcohol of penetrating, natural cooling at least 12h, handling material are spare.
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, cross 80-120 mesh sieve, it is mixed that bulk pharmaceutical chemicals are then added to three-dimensional movement
35min is mixed in conjunction machine.Then it mixes.
4）Flour slurry processed：Flour and purified water are mixed into paste, be then then added to by boiling purified water at a simmer into
Row stirring, stirring to slurry color and luster it is gentle after, be made flour slurry.Flour and the mass ratio of purified water are 38:120.
5）Softwood processed：The coral powder that bulk pharmaceutical chemicals gross mass 1% is added into bulk pharmaceutical chemicals, mixed bulk pharmaceutical chemicals are added to
In mixing machine, it is slowly added into flour slurry, 10min is stirred, the uniformly softwood without agglomerate is made；The mass ratio of bulk pharmaceutical chemicals and flour slurry
It is 4.5:1.Then it takes softwood to be placed in oscillating granulator, carries out whole grain, wet grain is made.
The coral powder is by pretreatment, specially：It takes coral and it is eluted with water, after 80 mesh of pulverizing sieve,
Pickling is carried out to coral powder surface with the hydrochloric acid solution of 5wt%, 400 mesh sieve was regrind after pickling, it is under nitrogen protection, right
Coral powder first roasts 1h at 300 DEG C, is then warming up to 950 DEG C and continues to roast 1h, takes out, in mass ratio 22:1 by itself and lecithin
Fat is mixed, and packet oil film is carried out to coral powder surface after roasting, and pretreated coral powder is made.
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made.
7）It is dry：Wet knee-piece is dried, drying temperature is 70 DEG C, drying time 26h, and moisture control is 5% after drying
Hereinafter, dry medium block is made.
8）Packaging：After being packed to dry medium block, finished product.
1 piece is weighed respectively（7g）Chinese eaglewood medicated leaven made from embodiment 1 and 3 puts into 500mL, 38 DEG C, pH 3（Simulate stomach ring
Border）Water in, detect solution rate.
Testing result shows, the Chinese eaglewood medicated leaven of embodiment 1 be completely dissolved the time required in the sections 50-60min, embodiment 3
Chinese eaglewood medicated leaven is distinguished the time required to being completely dissolved in 15-30min, and Chinese eaglewood medicated leaven in the prior art is completely dissolved required time and exists
The sections 50-70min.
Raw materials used in the present invention, equipment is unless otherwise noted the common raw material, equipment of this field；In the present invention
Method therefor is unless otherwise noted the conventional method of this field.
The above is only presently preferred embodiments of the present invention, is not imposed any restrictions to the present invention, every according to the present invention
Technical spirit still falls within the technology of the present invention side to any simple modification, change and equivalent transformation made by above example
The protection domain of case.
Claims (6)
1. a kind of preparation method of Chinese eaglewood medicated leaven, it is characterised in that include the following steps：
1）Weighing：18 parts of agalloch eaglewood, 18 parts of root of Aucklandia lappa Decne, 9 parts of radix bupleuri, 9 parts of ginger Cortex Magnoliae Officinalis, 9 parts of cardamom, 9 parts of fructus amomi, Radix Curcumae are weighed respectively
9 parts, 36 parts windproof, 9 parts of pueraria lobata, 36 parts of the root of three-nerved spicebush, 36 parts of Fructus Aurantii, 36 parts of dried orange peel, 36 parts of campanulaceae, 36 parts of betel nut, frying malt 36
Part, 36 parts of frying rice sprout, 36 parts of the root of purple-flowered peucedanum, 36 parts of bran fried green skin, 36 parts of the root of Dahurain angelica, 27 parts of santal, 27 parts of dalbergia wood, 27 parts of Rhizoma Et Radix Notopterygii, the leaves of pulse plants
Fragrant 27 parts and 13.5 parts of Radix Glycyrrhizae；
2）Sterilizing：It sterilizes respectively to the bulk pharmaceutical chemicals；
3）Batch mixing：Bulk pharmaceutical chemicals are crushed respectively, are then mixed；
4）Flour slurry processed：Flour and purified water are mixed into paste, being then then added to will stir in boiling purified water at a simmer
Mix, stirring to slurry color and luster it is gentle after, be made flour slurry；
5）Softwood processed：Mixed bulk pharmaceutical chemicals are added in mixing machine, the 1-5% that quality is bulk pharmaceutical chemicals is added into bulk pharmaceutical chemicals
Coral powder, then be slowly added into flour slurry, stir 5-10min, the uniformly softwood without agglomerate is made, then takes softwood to be placed in and waves
In formula granulator, whole grain is carried out, wet grain is made；
The coral powder is by pretreatment：It takes coral and it is eluted with water, after 20-80 mesh of pulverizing sieve, use 1-5wt%
Hydrochloric acid solution to coral powder surface carry out pickling, regrind after pickling 200-400 mesh sieve, under nitrogen protection, to coral
Coral powder first roasts 1-3h at 200-300 DEG C, is then warming up to 900-950 DEG C and continues to roast 1-2h, takes out, 18- in mass ratio
22:1 itself and lecithin are mixed, and packet oil film is carried out to coral powder surface after roasting, and pretreated coral powder is made；
6）Briquetting：Briquetting is carried out to wet grain, wet knee-piece is made；
7）It is dry：Wet knee-piece is dried, dry medium block is made；
8）Packaging：After being packed to dry medium block, finished product.
2. a kind of preparation method of Chinese eaglewood medicated leaven as described in claim 1, which is characterized in that step 2）In, sterilize specific method
For：Bulk pharmaceutical chemicals are set in sterilizing installation, then the insulated sterilizing at least 2h at 55-75 DEG C is evacuated to 0.07MPa or more, spray
Enter the ethyl alcohol of suitable a concentration of 88-92%, natural cooling at least 12h, handling material is spare.
3. a kind of preparation method of Chinese eaglewood medicated leaven as described in claim 1, which is characterized in that step 3）In, smash it through 80-
120 mesh sieve, and then bulk pharmaceutical chemicals are added in three-dimensional movement mixer and mix 25-35min.
4. a kind of preparation method of Chinese eaglewood medicated leaven as described in claim 1, which is characterized in that step 4）In, flour and purified water
Mass ratio be 37-38:120.
5. a kind of preparation method of Chinese eaglewood medicated leaven as described in claim 1, which is characterized in that step 5）In, bulk pharmaceutical chemicals and flour
The mass ratio of slurry is 3.5-4.5:1.
6. a kind of preparation method of Chinese eaglewood medicated leaven as described in claim 1, which is characterized in that step 7）In, drying temperature 50-
70 DEG C, drying time 26-34h, moisture control is below 5% after drying.
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| CN1055851C (en) * | 1996-09-28 | 2000-08-30 | 郑文学 | Weixiandan as medicine for gastropathy |
| CN101011501A (en) * | 2007-02-06 | 2007-08-08 | 王剑 | Linaloe tea and its making technique |
| CN104224738A (en) * | 2014-09-11 | 2014-12-24 | 葛强 | Single traditional Chinese medicine pills and preparation method thereof |
| CN106138906A (en) * | 2016-08-23 | 2016-11-23 | 明少英 | A kind of Chinese eaglewood medicated leaven biologic ferment preparation |
| CN106942297A (en) * | 2017-03-08 | 2017-07-14 | 方尉 | A kind of line spices of expelling parasite dehumidifying and preparation method thereof |
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Denomination of invention: A preparation method of agaric Koji Effective date of registration: 20220624 Granted publication date: 20180720 Pledgee: Xianju Branch of Industrial and Commercial Bank of China Ltd. Pledgor: TAIZHOU NANFENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022330001091 |