CN107529809A - 核苷酸组合物及其在食品中的应用 - Google Patents
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- CN107529809A CN107529809A CN201680013841.3A CN201680013841A CN107529809A CN 107529809 A CN107529809 A CN 107529809A CN 201680013841 A CN201680013841 A CN 201680013841A CN 107529809 A CN107529809 A CN 107529809A
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- 235000011180 diphosphates Nutrition 0.000 description 1
- QLBHNVFOQLIYTH-UHFFFAOYSA-L dipotassium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O QLBHNVFOQLIYTH-UHFFFAOYSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PVBRXXAAPNGWGE-LGVAUZIVSA-L disodium 5'-guanylate Chemical compound [Na+].[Na+].C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O PVBRXXAAPNGWGE-LGVAUZIVSA-L 0.000 description 1
- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
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- 238000011207 functional examination Methods 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000009698 intestinal cell proliferation Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000020185 raw untreated milk Nutrition 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940099992 seromycin Drugs 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000012859 sterile filling Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/13—Nucleic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pediatric Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
Abstract
Description
Claims (19)
- 一种用作食品添加物的核苷酸组合物,其中按重量计,所述组合物基本上由CMP、AMP、UMP和GMP组成,并且各组分的比例为CMP:58~72%、AMP:6~14%、UMP:10~18%以及GMP:8~14%,条件是各种组分之和为100%。
- 权利要求1的组合物,其中各组分的比例为CMP:60~70%、AMP:8~12%、UMP:12~16%以及GMP:10~12%,条件是各种组分之和为100%。
- 权利要求1的组合物,其中各组分的比例为CMP:60~65%、AMP:10~12%、UMP:14~16%以及GMP:11~12%,条件是各种组分之和为100%。
- 权利要求1的组合物,其中各组分的比例为CMP:65~70%、AMP:8~10%、UMP:12~14%以及GMP:10~11%,条件是各种组分之和为100%。
- 权利要求1-4中任一项的组合物,其中各组分的比例为CMP:60%、AMP:12%、UMP:16%以及GMP:12%;CMP:65%、AMP:10%、UMP:14%以及GMP:11%;或者CMP:70%、AMP:8%、UMP:12%以及GMP:10%。
- 一种用作食品添加物的核苷酸组合物,其中按重量计,所述组合物基本上由CMP、AMP、UMP、GMP和IMP组成,并且各组分的比例为CMP:58~70%、AMP:7.5~12.5%、UMP:12~16.5%、GMP:10~13%以及IMP:0~2.5%,条件是各种组分之和为100%。
- 权利要求6的组合物,其中各组分的比例为CMP:60~65%、AMP:8~12%、UMP:14~16%、GMP:11~12%以及IMP:0~2%,条件是各种组分之和为100%。
- 权利要求1-7中任一项的组合物,其中所述食品为婴幼儿食品。
- 权利要求1-8中任一项的组合物,其中所述食品为乳制品的形式。
- 权利要求1-9中任一项的组合物,其中所述食品为奶粉或液态乳制品的形式。
- 一种食品,其包含权利要求1-10中任一项的核苷酸组合物。
- 权利要求11的食品,其为婴幼儿食品。
- 权利要求11或12的食品,其中所述食品为乳制品的形式。
- 权利要求11-13中任一项的食品,其中所述食品为为奶粉或液态乳制品的形式。
- 权利要求1-10中任一项的核苷酸组合物在制备食品中的应用。
- 权利要求15的应用,其中所述食品为婴幼儿食品。
- 权利要求15或16的应用,其中所述食品为乳制品的形式。
- 权利要求15-17中任一项的应用,其中所述食品为奶粉或液态乳制品的形式。
- 权利要求15-18中任一项的应用,其中所述食品用于实现以下方面的效果:提供免疫刺激效果、促进生长发育、促进肠道损伤后的修复、促进肠道有益微生物的生长和/或它们的任意组合。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN2015100998506 | 2015-03-06 | ||
CN201510099850.6A CN105982074A (zh) | 2015-03-06 | 2015-03-06 | 核苷酸组合物及其在食品中的应用 |
PCT/CN2016/074813 WO2016141812A1 (zh) | 2015-03-06 | 2016-02-29 | 核苷酸组合物及其在食品中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN107529809A true CN107529809A (zh) | 2018-01-02 |
CN107529809B CN107529809B (zh) | 2020-03-13 |
Family
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Application Number | Title | Priority Date | Filing Date |
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CN201510099850.6A Pending CN105982074A (zh) | 2015-03-06 | 2015-03-06 | 核苷酸组合物及其在食品中的应用 |
CN201680013841.3A Active CN107529809B (zh) | 2015-03-06 | 2016-02-29 | 核苷酸组合物及其在食品中的应用 |
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CN201510099850.6A Pending CN105982074A (zh) | 2015-03-06 | 2015-03-06 | 核苷酸组合物及其在食品中的应用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20180049460A1 (zh) |
EP (1) | EP3266310B1 (zh) |
CN (2) | CN105982074A (zh) |
AU (1) | AU2016228670B2 (zh) |
DK (1) | DK3266310T3 (zh) |
ES (1) | ES2805825T3 (zh) |
MY (1) | MY186145A (zh) |
SG (2) | SG11201707213PA (zh) |
WO (1) | WO2016141812A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113519805A (zh) * | 2021-07-27 | 2021-10-22 | 大连珍奥生物技术股份有限公司 | 一种调节肠道菌群的核苷酸益生菌泡菜及其制备方法 |
CN113616667A (zh) * | 2021-07-27 | 2021-11-09 | 大连珍奥生物技术股份有限公司 | 一种辅助治疗糖尿病的核苷酸组合物及其制备方法和应用 |
WO2024067345A1 (zh) * | 2022-09-26 | 2024-04-04 | 黑龙江飞鹤乳业有限公司 | 核苷酸的用途、营养组合物、食品及其用途 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117378767B (zh) * | 2023-12-12 | 2024-04-09 | 内蒙古伊利实业集团股份有限公司 | 一种可促进生长追赶的营养组合物及其应用 |
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CN1282585A (zh) * | 2000-07-25 | 2001-02-07 | 许振亚 | 一种复合核苷酸制剂 |
CN101376906A (zh) * | 2008-10-06 | 2009-03-04 | 张剑秋 | 一种混合核苷酸的生产方法 |
CN101559069A (zh) * | 2009-05-27 | 2009-10-21 | 珍奥集团股份有限公司 | 5’核苷酸在制备缓解体力疲劳药物、保健食品中的用途 |
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JP3173844B2 (ja) * | 1992-03-03 | 2001-06-04 | 雪印乳業株式会社 | 生体組織内ω3系脂肪酸増加剤及びそれを含む栄養組成物 |
CN1048400C (zh) * | 1994-05-19 | 2000-01-19 | 颜怀玮 | 维生素微量元素嘌呤嘧啶双核苷酸营养素产品及制造方法 |
CN1364417A (zh) * | 2001-01-09 | 2002-08-21 | 许振亚 | 核苷酸牛奶 |
WO2004032651A1 (en) * | 2002-10-10 | 2004-04-22 | Wyeth | Infant formula containing nucleotides |
US8293264B2 (en) * | 2009-05-11 | 2012-10-23 | Mead Johnson Nutrition Company | Nutritional composition to promote healthy development and growth |
MX2012010487A (es) * | 2012-09-11 | 2014-03-26 | Nucitec Sa De Cv | Composicion de nutrimientos y sustancias bioactivas que favorecen el crecimiento y que disminuyen la intolerancia y los efectos adversos en infantes prematuros. |
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2015
- 2015-03-06 CN CN201510099850.6A patent/CN105982074A/zh active Pending
-
2016
- 2016-02-29 DK DK16761039.3T patent/DK3266310T3/da active
- 2016-02-29 AU AU2016228670A patent/AU2016228670B2/en active Active
- 2016-02-29 ES ES16761039T patent/ES2805825T3/es active Active
- 2016-02-29 SG SG11201707213PA patent/SG11201707213PA/en unknown
- 2016-02-29 MY MYPI2017703243A patent/MY186145A/en unknown
- 2016-02-29 EP EP16761039.3A patent/EP3266310B1/en active Active
- 2016-02-29 SG SG10201908193P patent/SG10201908193PA/en unknown
- 2016-02-29 CN CN201680013841.3A patent/CN107529809B/zh active Active
- 2016-02-29 WO PCT/CN2016/074813 patent/WO2016141812A1/zh active Application Filing
- 2016-02-29 US US15/555,867 patent/US20180049460A1/en not_active Abandoned
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CN1282585A (zh) * | 2000-07-25 | 2001-02-07 | 许振亚 | 一种复合核苷酸制剂 |
CN101376906A (zh) * | 2008-10-06 | 2009-03-04 | 张剑秋 | 一种混合核苷酸的生产方法 |
CN101559069A (zh) * | 2009-05-27 | 2009-10-21 | 珍奥集团股份有限公司 | 5’核苷酸在制备缓解体力疲劳药物、保健食品中的用途 |
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CN113519805A (zh) * | 2021-07-27 | 2021-10-22 | 大连珍奥生物技术股份有限公司 | 一种调节肠道菌群的核苷酸益生菌泡菜及其制备方法 |
CN113616667A (zh) * | 2021-07-27 | 2021-11-09 | 大连珍奥生物技术股份有限公司 | 一种辅助治疗糖尿病的核苷酸组合物及其制备方法和应用 |
CN113519805B (zh) * | 2021-07-27 | 2022-03-25 | 陈玉松 | 一种调节肠道菌群的核苷酸益生菌泡菜及其制备方法 |
WO2024067345A1 (zh) * | 2022-09-26 | 2024-04-04 | 黑龙江飞鹤乳业有限公司 | 核苷酸的用途、营养组合物、食品及其用途 |
Also Published As
Publication number | Publication date |
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SG11201707213PA (en) | 2017-10-30 |
CN105982074A (zh) | 2016-10-05 |
DK3266310T3 (da) | 2020-07-27 |
CN107529809B (zh) | 2020-03-13 |
WO2016141812A1 (zh) | 2016-09-15 |
SG10201908193PA (en) | 2019-10-30 |
EP3266310A4 (en) | 2018-09-26 |
EP3266310B1 (en) | 2020-06-24 |
AU2016228670A1 (en) | 2017-10-19 |
EP3266310A1 (en) | 2018-01-10 |
ES2805825T3 (es) | 2021-02-15 |
US20180049460A1 (en) | 2018-02-22 |
AU2016228670B2 (en) | 2020-05-21 |
NZ735399A (en) | 2020-11-27 |
MY186145A (en) | 2021-06-26 |
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