CN103830674B - One treats lipomatous pharmaceutical composition and preparation method and purposes - Google Patents
One treats lipomatous pharmaceutical composition and preparation method and purposes Download PDFInfo
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- CN103830674B CN103830674B CN201410068476.9A CN201410068476A CN103830674B CN 103830674 B CN103830674 B CN 103830674B CN 201410068476 A CN201410068476 A CN 201410068476A CN 103830674 B CN103830674 B CN 103830674B
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Abstract
Disclosure one treats lipomatous pharmaceutical composition, is made up of following raw material: Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae part, Bulbus Fritillariae Thunbergii, Concha Meretricis seu Cyclinae, Concha Arcae, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae, Radix Glycyrrhizae。Preparation method: S1: claim Concha Meretricis seu Cyclinae and Concha Arcae in proportion, soak after mixing and decoct；S2: add water after weighing Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing in proportion；S3: decocting after the medicinal liquid of S1 and medicinal residues being mixed with the medical material of S2, filter to obtain decocting liquid, medicinal residues are standby；S4: the medicinal residues of S3 being added soak by water and filters to obtain decocting liquid, medicinal residues discard；S5: merged with the decocting liquid of S4 by the decocting liquid of S3 and be condensed into extractum and dry, pulverize, adds adjuvant and is prepared from。The present invention forms simply, novel formula has that cost is low, good effect, have no side effect, be not likely to produce toleration, take and easy to carry, suitable in lipomatous patient。
Description
Technical field
The present invention relates to one and treat lipomatous pharmaceutical composition and preparation method thereof。
Background technology
Lipoma is initiated by the benign tumor of fatty tissue, is made up of ripe fatty tissue, and all internal positions having fat existence all can occur, and lipoma has fibrointimal one layer thin, inside has a lot of fiber rope, forms a lot of interval in length and breadth。Being most commonly in the subcutaneous tissue of neck, shoulder, the back of the body, buttocks and breast and limbs, secondly face, scalp, scrotum and labia are after peritoneum and gastrointestinal wall etc.；Only a few may occur in which in the position of original fat-free mass, if fibrous tissue proportion is more in tumor, then claims fibrolipoma。Can be divided into and have isolatism lipoma and lipomatosis by number according to lipomatous。Tumor body constitution ground is soft, circular or lobulated, located subcutaneously, it is possible to promote；Not etc., little is as not big in Fructus Jujubae for tumorous size, with hands touch can stereognosis, big swelled surface, but surface skin is normal, many no conscious symptons。The patient sought medical advice because of subcutaneous fat tumor clinically is more, and the mood especially sought medical advice with blue or green, aged patients is the most urgent。Less subcutaneous fat tumor doctor trained in Western medicine is often advised that patient is without treatment, to be viewed as master, treats without any specific drugs, for bigger subcutaneous fat tumor then based on excision。Subcutaneous fat tumor belongs to the category of the traditional Chinese medical science " physocele ", " sarcoma ", " sucutaneous nodule ", and it is the Basic disease cause of primary disease that depressed, blood stasis, expectorant coagulate, and can obtain satisfied clinical efficacy after being treated by promoting flow of QI and blood blood stasis dispelling。
Summary of the invention
It is an object of the present invention to overcome the deficiencies in the prior art, there is provided one composition simple, the lipomatous pharmaceutical composition for the treatment of of novel formula, this pharmaceutical composition has that cost is low, good effect, have no side effect, be not likely to produce toleration, take and easy to carry, be generally applicable to the features such as lipomatous patient。
Further object is that a kind of preparation method treating lipomatous pharmaceutical composition of offer, this preparation method is simple to operate, is applicable to industrialized production。
It is an object of the invention to be achieved through the following technical solutions: one treats lipomatous pharmaceutical composition, it is characterised in that: it is made up of the raw material of following ratio of weight and number: 15～60 parts of Poria, Spica Prunellae 10～50 parts, Fructus Forsythiae 10～50 parts, Semen Sinapis Albae 10～50 parts, Bulbus Fritillariae Thunbergii 10～50 parts, Concha Meretricis seu Cyclinae 10～50 parts, Concha Arcae 10～50 parts, Rhizoma Curcumae 10～50 parts, Caulis Bambusae In Taenia 10～50 parts, Fructus Aurantii Immaturus 10～50 parts, Rhizoma Pinelliae Preparatum 5～40 parts, Pericarpium Citri Reticulatae 5～40 parts, 1～10 part of Radix Glycyrrhizae。
Preferably, the ratio of weight and number of described each raw material is: 20～50 parts of Poria, Spica Prunellae 15～40 parts, Fructus Forsythiae 15～40 parts, Semen Sinapis Albae 15～40 parts, Bulbus Fritillariae Thunbergii 15～40 parts, Concha Meretricis seu Cyclinae 15～40 parts, Concha Arcae 15～40 parts, Rhizoma Curcumae 15～40 parts, Caulis Bambusae In Taenia 15～40 parts, Fructus Aurantii Immaturus 15～40 parts, Rhizoma Pinelliae Preparatum 10～30 parts, Pericarpium Citri Reticulatae 10～30 parts, 3～8 parts of Radix Glycyrrhizae。
Preferably, the ratio of weight and number of described each raw material is: 25～40 parts of Poria, Spica Prunellae 20～35 parts, Fructus Forsythiae 20～35 parts, Semen Sinapis Albae 20～35 parts, Bulbus Fritillariae Thunbergii 20～35 parts, Concha Meretricis seu Cyclinae 20～35 parts, Concha Arcae 20～35 parts, Rhizoma Curcumae 20～35 parts, Caulis Bambusae In Taenia 20～35 parts, Fructus Aurantii Immaturus 20～35 parts, Rhizoma Pinelliae Preparatum 15～25 parts, Pericarpium Citri Reticulatae 15～25 parts, 4～6 parts of Radix Glycyrrhizae。
Preferably, the ratio of weight and number of described each raw material is: 30 parts of Poria, Spica Prunellae 25 parts, Fructus Forsythiae 25 parts, Semen Sinapis Albae 25 parts, Bulbus Fritillariae Thunbergii 25 parts, Concha Meretricis seu Cyclinae 25 parts, Concha Arcae 25 parts, Rhizoma Curcumae 25 parts, Caulis Bambusae In Taenia 25 parts, Fructus Aurantii Immaturus 25 parts, Rhizoma Pinelliae Preparatum 20 parts, Pericarpium Citri Reticulatae 20 parts, 5 parts of Radix Glycyrrhizae。
Preferably, the ratio of weight and number of described each raw material is: 20 parts of Poria, Spica Prunellae 15 parts, Fructus Forsythiae 15 parts, Semen Sinapis Albae 15 parts, Bulbus Fritillariae Thunbergii 15 parts, Concha Meretricis seu Cyclinae 15 parts, Concha Arcae 15 parts, Rhizoma Curcumae 15 parts, Caulis Bambusae In Taenia 15 parts, Fructus Aurantii Immaturus 15 parts, Rhizoma Pinelliae Preparatum 12 parts, Pericarpium Citri Reticulatae 12 parts, 3 parts of Radix Glycyrrhizae。
A kind of method preparing above-mentioned any one pharmaceutical composition, it is characterised in that: it comprises the following steps:
S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently；
S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；
S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；
S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；
S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmaceutically acceptable adjuvant and prepares into pharmaceutically conventional pharmaceutical preparation。
Pharmaceutical preparation of the present invention is tablet, capsule, granule, powder or oral liquid。
Pharmaceutically acceptable adjuvant of the present invention includes starch, magnesium stearate, dextrin and microcrystalline Cellulose。
The pharmaceutical composition of the present invention application in preparation treatment lipoma medicine, it is preferable that the pharmaceutical composition of the present invention application in preparation treatment subcutaneous fat tumor medicine。
The pharmaceutical composition of the present invention can prepare into dosage form described on any pharmaceutics according to the conventional method of pharmaceutical field；Pharmaceutical composition can be applied to patient by modes such as oral, suction or intestinal external administrations。The described dosage form on pharmaceutics includes: the tablet of use, capsule, pill, powder, granule, syrup, oral liquid etc. during oral administration；The freeze-dried powder used when intestinal external administration and injection etc.。
For making above-mentioned dosage form be capable of, pharmaceutically acceptable adjuvant need to be added when preparing these dosage forms, for instance: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, preservative, substrate etc.。Filler includes: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.；Disintegrating agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.；Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Binding agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods；Substrate includes: PEG6000, PEG4000, insect wax etc.。
Poria in pharmaceutical composition of the present invention, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Concha Meretricis seu Cyclinae, Concha Arcae, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are 2010 editions " Chinese Pharmacopoeias " first Chinese medicine recorded or its processed product。Poria is the sclerotium of On Polyporaceae Poria, has the effect of promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming；Spica Prunellae is the fruit ear of Labiatae herbaceos perennial Spica Prunellae, has the effect letting out clearly liver-fire, mass dissipating and swelling eliminating；Fructus Forsythiae is the fruit of Oleaceae machaka Fructus Forsythiae, has heat-clearing and toxic substances removing, dispelling wind and heat pathogens, the effect of eliminating carbuncle eliminating stagnation；Semen Sinapis Albae is the dry mature seed of crucifer Caulis et Folium Sinapis albee, has and reduces phlegm by drink, the effect of mass dissipating and swelling eliminating；Bulbus Fritillariae Thunbergii is the bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii, has removing heat-phlegm, the effect of dissipating depression of QI eliminating stagnation；Concha Meretricis seu Cyclinae is the shell of the multiple sea clams such as Veneridae animal Conch Meretricis seu Cyclinae, Concha Meretricis Seu Cyclinae；Concha Arcae is the shell of Carnis Arca inflata section animal Scapharca subcrenata, Tegillarca granosa or Scapharca broughtonii, has eliminating phlegm and softening indurated mass, the effect of blood stasis-eliminating and stagnation-dissipating；Rhizoma Curcumae is the rhizome of Zingiberaceae herbaceos perennial Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE, has removing blood stasis circulation of qi promoting, the effect of removing food stagnancy pain relieving；Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, has removing heat-phlegm, the effect relieved restlessness and prevented vomiting；The dry young fruit of Fructus Aurantii Immaturus rutaceae Citrus aurantium Linn. and variety or Fructus Citri sinensis, has dispelling the stagnated QI except painful abdominal mass, the effect of transforming phlegm and dispersing accumulations；Rhizoma Pinelliae Preparatum is the processed product of the Rhizoma Pinelliae, and the Rhizoma Pinelliae is the tuber of the aroid Rhizoma Pinelliae, has the effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；Pericarpium Citri Reticulatae is the mature peel of rutaceae orange and variety thereof, has the effect of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm；Radix Glycyrrhizae is glycyrrhizic legume, the root of Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. or rhizome, has the effect of QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine。
The invention has the beneficial effects as follows: inventive formulation is novel, composition is simple, proves that lipomatous patient is had good clinical efficacy by clinical research, in formula, each taste principal agent price is all inexpensively, holistic cost is cheap, and preparation method is simple to operate, is applicable to industrialized production。
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme is described in further detail, but protection scope of the present invention is not limited to the following stated。
Embodiment 1:
Weigh raw material Poria 15g, Spica Prunellae 10g, Fructus Forsythiae 10g, Semen Sinapis Albae 10g, Bulbus Fritillariae Thunbergii 10g, Concha Meretricis seu Cyclinae 10g, Concha Arcae 10g, Rhizoma Curcumae 10g, Caulis Bambusae In Taenia 10g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae Preparatum 5g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 1g, add supplementary product starch 100g to granulate, magnesium stearate 5g, dextrin 100g, microcrystalline Cellulose 100g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 2:
Weigh raw material Poria 60g, Spica Prunellae 50g, Fructus Forsythiae 50g, Semen Sinapis Albae 50g, Bulbus Fritillariae Thunbergii 50g, Concha Meretricis seu Cyclinae 50g, Concha Arcae 50g, Rhizoma Curcumae 50g, Caulis Bambusae In Taenia 50g, Fructus Aurantii Immaturus 50g, Rhizoma Pinelliae Preparatum 40g, Pericarpium Citri Reticulatae 40g, Radix Glycyrrhizae 10g, add supplementary product starch 600g to granulate, magnesium stearate 30g, dextrin 500g, microcrystalline Cellulose 500g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 3:
Weigh raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g part, Caulis Bambusae In Taenia 15g part, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 10g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 3g, add supplementary product starch 180g to granulate, magnesium stearate 12g, dextrin 120g, microcrystalline Cellulose 120g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 4:
Weigh raw material Poria 50g, Spica Prunellae 40g, Fructus Forsythiae 40g, Semen Sinapis Albae 40g, Bulbus Fritillariae Thunbergii 40g, Concha Meretricis seu Cyclinae 40g, Concha Arcae 40g, Rhizoma Curcumae 40g, Caulis Bambusae In Taenia 40g, Fructus Aurantii Immaturus 40g, Rhizoma Pinelliae Preparatum 30g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 8g, add supplementary product starch 450g to granulate, magnesium stearate 30g, dextrin 350g, microcrystalline Cellulose 350g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 5:
Weigh raw material Poria 25g, Spica Prunellae 20g, Fructus Forsythiae 20g, Semen Sinapis Albae 20g, Bulbus Fritillariae Thunbergii 20g, Concha Meretricis seu Cyclinae 20g, Concha Arcae 20g, Rhizoma Curcumae 20g, Caulis Bambusae In Taenia 20g, Fructus Aurantii Immaturus 20g, Rhizoma Pinelliae Preparatum 15g, Pericarpium Citri Reticulatae 15g, Radix Glycyrrhizae 4g, add supplementary product starch 250g to granulate, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 6:
Weigh raw material Poria 40g, Spica Prunellae 35g, Fructus Forsythiae 35g, Semen Sinapis Albae 35g, Bulbus Fritillariae Thunbergii 35g, Concha Meretricis seu Cyclinae 35g, Concha Arcae 35g, Rhizoma Curcumae 35g, Caulis Bambusae In Taenia 35g, Fructus Aurantii Immaturus 35g, Rhizoma Pinelliae Preparatum 25g, Pericarpium Citri Reticulatae 25g, Radix Glycyrrhizae 6g, add supplementary product starch 300g to granulate, magnesium stearate 30g, dextrin 250g, microcrystalline Cellulose 200g, uniformly prepare granule, tabletting, obtain tablet。
Embodiment 7:
Weigh raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g, add supplementary product starch 280g to granulate, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, uniformly prepare granule, load capsule, obtain capsule。
Embodiment 8:
Weigh raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g, adds supplementary product starch 180g and granulates, magnesium stearate 15g, dextrin 150g, microcrystalline Cellulose 150g, conventionally technique prepares into granule。
Embodiment 9:
Weigh raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g, adds supplementary product starch 280g and granulates, magnesium stearate 20g, dextrin 200g, microcrystalline Cellulose 200g, conventionally technique prepares into oral liquid。
Embodiment 10:
Weigh raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g, adds supplementary product starch 180g and granulates, magnesium stearate 15g, dextrin 150g, microcrystalline Cellulose 150g, conventionally technique prepares into powder。
Embodiment 11:
Weigh raw material Poria 15g, Spica Prunellae 10g, Fructus Forsythiae 10g, Semen Sinapis Albae 10g, Bulbus Fritillariae Thunbergii 10g, Concha Meretricis seu Cyclinae 10g, Concha Arcae 10g, Rhizoma Curcumae 10g, Caulis Bambusae In Taenia 10g, Fructus Aurantii Immaturus 10g, Rhizoma Pinelliae Preparatum 5g, Pericarpium Citri Reticulatae 5g, Radix Glycyrrhizae 1g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into tablet。
Embodiment 12:
Weigh raw material Poria 60g, Spica Prunellae 50g, Fructus Forsythiae 50g, Semen Sinapis Albae 50g, Bulbus Fritillariae Thunbergii 50g, Concha Meretricis seu Cyclinae 50g, Concha Arcae 50g, Rhizoma Curcumae 50g, Caulis Bambusae In Taenia 50g, Fructus Aurantii Immaturus 50g, Rhizoma Pinelliae Preparatum 40g, Pericarpium Citri Reticulatae 40g, Radix Glycyrrhizae 10g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into tablet。
Embodiment 13:
Weigh raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g part, Caulis Bambusae In Taenia 15g part, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 10g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 3g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into capsule。
Embodiment 14:
Weigh raw material Poria 50g, Spica Prunellae 40g, Fructus Forsythiae 40g, Semen Sinapis Albae 40g, Bulbus Fritillariae Thunbergii 40g, Concha Meretricis seu Cyclinae 40g, Concha Arcae 40g, Rhizoma Curcumae 40g, Caulis Bambusae In Taenia 40g, Fructus Aurantii Immaturus 40g, Rhizoma Pinelliae Preparatum 30g, Pericarpium Citri Reticulatae 30g, Radix Glycyrrhizae 8g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into granule。
Embodiment 15:
Weigh raw material Poria 25g, Spica Prunellae 20g, Fructus Forsythiae 20g, Semen Sinapis Albae 20g, Bulbus Fritillariae Thunbergii 20g, Concha Meretricis seu Cyclinae 20g, Concha Arcae 20g, Rhizoma Curcumae 20g, Caulis Bambusae In Taenia 20g, Fructus Aurantii Immaturus 20g, Rhizoma Pinelliae Preparatum 15g, Pericarpium Citri Reticulatae 15g, Radix Glycyrrhizae 4g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into oral liquid。
Embodiment 16:
Weigh raw material Poria 40g, Spica Prunellae 35g, Fructus Forsythiae 35g, Semen Sinapis Albae 35g, Bulbus Fritillariae Thunbergii 35g, Concha Meretricis seu Cyclinae 35g, Concha Arcae 35g, Rhizoma Curcumae 35g, Caulis Bambusae In Taenia 35g, Fructus Aurantii Immaturus 35g, Rhizoma Pinelliae Preparatum 25g, Pericarpium Citri Reticulatae 25g, Radix Glycyrrhizae 6g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into powder。
Embodiment 17:
Weigh raw material Poria 30g, Spica Prunellae 25g, Fructus Forsythiae 25g, Semen Sinapis Albae 25g, Bulbus Fritillariae Thunbergii 25g, Concha Meretricis seu Cyclinae 25g, Concha Arcae 25g, Rhizoma Curcumae 25g, Caulis Bambusae In Taenia 25g, Fructus Aurantii Immaturus 25g, Rhizoma Pinelliae Preparatum 20g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 5g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into tablet。
Embodiment 18:
Weigh raw material Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g；Its preparation method comprises the following steps: S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, and after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently。S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmacy customary adjuvant and prepares into capsule。
Beneficial effects of the present invention is verified below by concrete clinical research:
1 physical data
Choose 52 example lipoma patients, 20～70 years old age, male 28 examples, female 24 example。The course of disease is many in 6 months to 10 years, 42 years old mean age。
2 diagnostic criterias
(1) send out in neck, shoulder, the back of the body and extremity, not of uniform size, in flat agglomerate or lobulated；(2) poor growth, no conscious sympton, matter is soft and flexible, can have pseudofluctuation。
3 experimental techniques
Experimental formula is: Poria 20g, Spica Prunellae 15g, Fructus Forsythiae 15g, Semen Sinapis Albae 15g, Bulbus Fritillariae Thunbergii 15g, Concha Meretricis seu Cyclinae 15g, Concha Arcae 15g, Rhizoma Curcumae 15g, Caulis Bambusae In Taenia 15g, Fructus Aurantii Immaturus 15g, Rhizoma Pinelliae Preparatum 12g, Pericarpium Citri Reticulatae 12g, Radix Glycyrrhizae 3g。Its decocting method is: S1: by Concha Meretricis seu Cyclinae and Concha Arcae, the water soaking of addition medical material 6～8 times amount 0.5～1 hour after mixing, decoct 0.5～1 hour subsequently, S2: Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae are mixed, adds the water of medical material 6～8 times amount；S3: common decoction 15～20min after the medicinal liquid of S1 step and medicinal residues are mixed with the medical material of S2 step, it is filtrated to get decocting liquid, medicinal residues are standby；S4: the medicinal residues in S3 step adding the soak by water 15～20min of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard。Instructions of taking: take 1 dose every day, every bu is taken for 3 times, within 3 months, is 1 course for the treatment of。Curative effect is added up after taking 1 course for the treatment of。
4 the standard of curative effect evaluations
Curing: tumor body atrophy, close to normal, simultaneous phenomenon disappears or substantially disappears；
Effective: tumor body is obviously reduced, and simultaneous phenomenon substantially alleviates；
Effective: tumor body and simultaneous phenomenon alleviate before all relatively treating；
Invalid: tumorous size, number do not change。
5 results
52 example patients are after 1 course for the treatment of drug treatment, and 27 examples of fully recovering (51.92%), effective 13 examples (25%), effective 9 examples (17.31%), invalid 3 examples (5.77%), total effective rate reaches 94.23%。Test and after terminating, each patient is carried out electrocardiogram, liver, kidney merit safety indexes inspection, each patient ECG, liver, kidney merit no abnormality seen。
Claims (10)
1. treat lipomatous pharmaceutical composition for one kind, it is characterised in that: it is made up of the raw material of following ratio of weight and number: 15～60 parts of Poria, Spica Prunellae 10～50 parts, Fructus Forsythiae 10～50 parts, Semen Sinapis Albae 10～50 parts, Bulbus Fritillariae Thunbergii 10～50 parts, Concha Meretricis seu Cyclinae 10～50 parts, Concha Arcae 10～50 parts, Rhizoma Curcumae 10～50 parts, Caulis Bambusae In Taenia 10～50 parts, Fructus Aurantii Immaturus 10～50 parts, Rhizoma Pinelliae Preparatum 5～40 parts, Pericarpium Citri Reticulatae 5～40 parts, 1～10 part of Radix Glycyrrhizae。
2. one according to claim 1 treats lipomatous pharmaceutical composition, it is characterised in that: the ratio of weight and number of described each raw material is: 20～50 parts of Poria, Spica Prunellae 15～40 parts, Fructus Forsythiae 15～40 parts, Semen Sinapis Albae 15～40 parts, Bulbus Fritillariae Thunbergii 15～40 parts, Concha Meretricis seu Cyclinae 15～40 parts, Concha Arcae 15～40 parts, Rhizoma Curcumae 15～40 parts, Caulis Bambusae In Taenia 15～40 parts, Fructus Aurantii Immaturus 15～40 parts, Rhizoma Pinelliae Preparatum 10～30 parts, Pericarpium Citri Reticulatae 10～30 parts, 3～8 parts of Radix Glycyrrhizae。
3. one according to claim 1 treats lipomatous pharmaceutical composition, it is characterised in that: the ratio of weight and number of described each raw material is: 25～40 parts of Poria, Spica Prunellae 20～35 parts, Fructus Forsythiae 20～35 parts, Semen Sinapis Albae 20～35 parts, Bulbus Fritillariae Thunbergii 20～35 parts, Concha Meretricis seu Cyclinae 20～35 parts, Concha Arcae 20～35 parts, Rhizoma Curcumae 20～35 parts, Caulis Bambusae In Taenia 20～35 parts, Fructus Aurantii Immaturus 20～35 parts, Rhizoma Pinelliae Preparatum 15～25 parts, Pericarpium Citri Reticulatae 15～25 parts, 4～6 parts of Radix Glycyrrhizae。
4. one according to claim 1 treats lipomatous pharmaceutical composition, it is characterised in that: the ratio of weight and number of described each raw material is: 30 parts of Poria, Spica Prunellae 25 parts, Fructus Forsythiae 25 parts, Semen Sinapis Albae 25 parts, Bulbus Fritillariae Thunbergii 25 parts, Concha Meretricis seu Cyclinae 25 parts, Concha Arcae 25 parts, Rhizoma Curcumae 25 parts, Caulis Bambusae In Taenia 25 parts, Fructus Aurantii Immaturus 25 parts, Rhizoma Pinelliae Preparatum 20 parts, Pericarpium Citri Reticulatae 20 parts, 5 parts of Radix Glycyrrhizae。
5. one according to claim 1 treats lipomatous pharmaceutical composition, it is characterised in that: the ratio of weight and number of described each raw material is: 20 parts of Poria, Spica Prunellae 15 parts, Fructus Forsythiae 15 parts, Semen Sinapis Albae 15 parts, Bulbus Fritillariae Thunbergii 15 parts, Concha Meretricis seu Cyclinae 15 parts, Concha Arcae 15 parts, Rhizoma Curcumae 15 parts, Caulis Bambusae In Taenia 15 parts, Fructus Aurantii Immaturus 15 parts, Rhizoma Pinelliae Preparatum 12 parts, Pericarpium Citri Reticulatae 12 parts, 3 parts of Radix Glycyrrhizae。
6. the method treating lipomatous pharmaceutical composition prepared in Claims 1 to 5 described in any one, it is characterised in that: it comprises the following steps:
S1: weigh Concha Meretricis seu Cyclinae and Concha Arcae by weight, after mixing, the water soaking of addition medical material 6～8 times amount 0.5～1 hour, decocts 0.5～1 hour subsequently；
S2: weigh Poria, Spica Prunellae, Fructus Forsythiae, Semen Sinapis Albae, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Caulis Bambusae In Taenia, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparatum, Pericarpium Citri Reticulatae and Radix Glycyrrhizae mixing by weight, add the water of medical material 6～8 times amount；
S3: common decoction 1～1.5 hour after the medicinal liquid of S1 step and medicinal residues being mixed with the medical material of S2 step, is filtrated to get decocting liquid, and medicinal residues are standby；
S4: the medicinal residues in S3 step adding the soak by water 1～1.5 hour of 6～8 times of medical material amounts, is filtrated to get decocting liquid, medicinal residues discard；
S5: be condensed into extractum after being merged with the decocting liquid in S4 step by the decocting liquid in S3 step, then obtains dry cream by extractum vacuum drying, and dried cream powder is broken, adds pharmaceutically acceptable adjuvant and prepares into pharmaceutically conventional pharmaceutical preparation。
7. method according to claim 6, it is characterised in that: described pharmaceutical preparation is tablet, capsule, granule, powder or oral liquid。
8. method according to claim 6, it is characterised in that: described pharmaceutically acceptable adjuvant includes starch, magnesium stearate, dextrin and microcrystalline Cellulose。
9. pharmaceutical composition as described in any one claim application in preparation treatment lipoma medicine in Claims 1 to 5。
10. application according to claim 9, it is characterised in that: described lipoma is subcutaneous fat tumor。
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| CN105214000A (en) * | 2015-11-09 | 2016-01-06 | 陈慧珊 | A kind of Chinese medicine oral liquid and preparation method for the treatment of subcutaneous fat tumor |
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| CN108114240A (en) * | 2018-02-01 | 2018-06-05 | 重庆跃龙生物制药有限公司 | Treat lipomatous Chinese medicine composition and its preparation method and application |
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