CN106692431A - Medicine for treating and preventing duck cholera and preparation method thereof - Google Patents
Medicine for treating and preventing duck cholera and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a medicine for treating and preventing duck cholera. The medicine is prepared from the following active pharmaceutical ingredients in parts by mass: 190-215 parts of agastache rugosus, 170-195 parts of coptis chinensis, 190-215 parts of rheum officinale, 280-320 parts of rhizoma atractylodis, 140-165 parts of radix astragali, 350-380 parts of dark plum, 180-215 parts of houttuynia cordata, 190-215 parts of cortex phellodendri and 290-320 parts of radix isatidis. In the medicine disclosed by the invention, with harmonious compatibility of the raw materials, the occurrence rate of duck cholera can be obviously reduced, and perfect prevention and treatment effects on duck cholera can be realized; and moreover, without toxic or side effect, the medicine is safe to use and avoids residues of harmful medicines.
Description
Technical field
Medicine the present invention relates to a kind of preventing and treating of duck epidemic disease and preparation method thereof, it is particularly a kind of to have substantially to dfuck cholera
Medicine of preventive and therapeutic action and preparation method thereof.
Background technology
Dfuck cholera is also called duck poultry and loses, and is the contagious disease caused by pasteurella multocida.Killing property Pasteur fowl more
The brevibacterium that bacillus is a kind of Gram-negative, do not move, there is pod membrane, not forming brood cell.In the culture of addition blood or serum
Dew drop sample petite is formed on base.Equal this disease of easy infection of duck of the susceptible various ages in days of dfuck cholera, various kinds, laying duckses are the most
It is susceptible.Route of infection mainly passes through alimentary canal and respiratory tract infection.It is many after strong virus force strain infection to pass through into septic, it is acute
Morbidity, case fatality rate is high, and slower compared with the course of disease after the strain infection of weak virulence, the death rate is not also high, often in sporadic.Precipitating factor master
If because cutting off the water supply fracture, suddenly change feed, the excessive grade environmental stress factor of mutation stocking density of air can all make duck
The neurological susceptibility of cholera is improved.The acute performance body temperature rising of dfuck cholera, poor appetite, mouth, nasal secretions and cause and exhale
Inhale difficult, attempt of shaking the head throws away larynx mucus, suffer from diarrhoea.Chronic type often shows as chornic arthritis, pneumonia, air bag inflammation etc..
Western medicine antibiotics, sulfa drugs, olaquindox etc. have certain effect to anti-disease of effecting a permanent cure, but also bring some to ask
Topic, such as treatment thoroughly, often do not recur after drug withdrawal；Abuse of antibiotics makes bacterial resistance occurred, causes scope of medication to reduce, medication
Dosage increases, and production cost increases, and heavy dose of medication produces certain side effect to body, and causes medicine in duck product
Remained high, finding the medicine for the treatment of and prevention dfuck cholera that is safer, efficient, having no toxic side effect turns into what people studied
Emphasis.
Western medicine focuses on Eradicates and removes disease and evil, eliminates the cause of disease；Chinese medicine emphasizes entirety, focuses on the resistance against diseases for improving body, adjust,
The various functions of body are balanced, using safe and reliable, western medicine disease is replaced using Chinese medicine, the kind that Western medicine can be overcome to exist
Plant defect.Therefore a kind of drug residue free for treating dfuck cholera, the generation that has no drug resistance, the significant special efficacy medium-height grass of clinical effectiveness are researched and developed
Medicine is one of the field scientific research technical staff new problem anxious to be resolved.
The content of the invention
The purpose of the present invention is to overcome the above-mentioned not enough of prior art and provide a kind of medicine for treating and preventing dfuck cholera,
Each material combination does not exist incompatibility in medicine of the invention, can substantially reduce the incidence of dfuck cholera, has very to dfuck cholera
Good preventive and therapeutic action, and have no toxic side effect, using safety, without hazardous drugs residual.
It is a further object of the present invention to provide a kind of preparation method of said medicine, its process is simple, its bulk drug is common,
Cheaply.
The technical scheme is that：A kind of medicine for treating and preventing dfuck cholera, it is matched by following masses part
Bulk drug is made：Wrinkled giant hyssop 190-215 parts, coptis 170-200 parts, rheum officinale 190-215 parts, rhizoma atractylodis 280-320 parts, Radix Astragali 140-
165 parts, dark plum 350-380 parts, cordate houttuynia 180-215 parts, golden cypress 190-215 parts, Radix Isatidis 290-320 parts.
Its further preferred mass part matches and is：Wrinkled giant hyssop 190-210 parts, coptis 170-195 parts, rheum officinale 190-210 parts,
Rhizoma atractylodis 280-315 parts, Radix Astragali 140-160 parts, dark plum 350-375 parts, cordate houttuynia 180-210 parts, golden cypress 190-210 parts, plate indigo plant
Root 290-315 parts.
Its further preferred mass part matches and is：Wrinkled giant hyssop 190-205 parts, coptis 170-190 parts, rheum officinale 190-205 parts,
Rhizoma atractylodis 290-315 parts, Radix Astragali 140-155 parts, dark plum 350-370 parts, cordate houttuynia 190-210 parts, golden cypress 190-205 parts, plate indigo plant
Root 290-310 parts.
Its further preferred mass part matches and is：Wrinkled giant hyssop 190-200 parts, coptis 170-190 parts, rheum officinale 190-200 parts,
Rhizoma atractylodis 290-310 parts, Radix Astragali 145-155 parts, dark plum 350-365 parts, cordate houttuynia 195-210 parts, golden cypress 195-205 parts, plate indigo plant
Root 290-305 parts.
Its further preferred mass part matches and is：Wrinkled giant hyssop 195-200 parts, coptis 180-190 parts, rheum officinale 195-200 parts,
Rhizoma atractylodis 300-310 parts, Radix Astragali 145-150 parts, dark plum 350-360 parts, cordate houttuynia 200-210 parts, golden cypress 195-200 parts, plate indigo plant
Root 300-305 parts.
Its further preferred mass part matches and is：200 parts of wrinkled giant hyssop, 180 parts of the coptis, 200 parts of rheum officinale, 300 parts of rhizoma atractylodis, Huang
150 parts of stilbene, 360 parts of dark plum, 200 parts of cordate houttuynia, 200 parts of golden cypress, 300 parts of Radix Isatidis.
Another technical scheme of the invention is：A kind of preparation method of the medicine for treating and preventing dfuck cholera, it is mainly wrapped
Include following steps：
First, bulk drug is weighed by formula；
2nd, the bulk drug that will claim is crushed, and is well mixed, and obtains medical treatment and prevent the medicine of dfuck cholera.
Further another technical scheme of the present invention is：After step 2 raw material is crushed, 100-300 mesh sieves are crossed.
Further another technical scheme of the present invention is：After step 2 raw material is crushed, 150-300 mesh sieves are crossed.
The primary raw material medicine that the present invention is used is described as follows：
Wrinkled giant hyssop：Also known as：Blending, grey announcement, mountain fennel etc., belong to tubular flower mesh,【Function with cure mainly】Eliminate dampness with aromatics, and middle preventing or arresting vomiting, hair
Table relieving summer-heat.For turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp table card, from the beginning of, burnout of generating heat, uncomfortable in chest not relax, cold-dampness closes heat, abdomen to damp-warm syndrome
Pain is vomited and diarrhoea, nasosinusitis headache.
The coptis：Alias：Taste connects, river connects, Rhizoma Coptidis, and category Ranunculaceae, Coptis herbaceos perennial, heat-clearing and damp-drying drug are rushed down
Fire removing toxic substances.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, mesh are vomitted
Red, toothache is quenched one's thirst, carbuncle swells furunculosis；Eczema is controlled outward, wet sore, duct is suppurated.It is burning hot that prepared RHIZOMA COPTIDIS with vino is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For hot eyes, mouth
Sore.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach anti-vomiting.Mutually tied for fever and chills, damp and hot middle resistance, feeling of fullness vomiting.The easypro liver anti-vomiting of cornel coptis.For
Liver-stomach disharmony, vomits acid regurgitation.
Rheum officinale：States Pharmacopoeia specifications medicine rheum officinale should be from sorrel, Rheum officinale, the dry root of Rheum tanguticum Maxim and root
Stem.Preceding excavation that autumn Mo cauline leaf is withered or secondary spring is germinateed, removes radicula, scrapes off crust, valve cutting or section, restricts and wears bunchiness drying or direct
Dry.【Nature and flavor and return through】Hardship, trembles with fear.Returns spleen, stomach, large intestine, liver, pericardium channel.【Function with cure mainly】Heat and toxic materials clearing away, clearing heat-fire,
Removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.For the stagnant constipation of real heat, blood-head tells nosebleed, hot eyes pharynx swelling, carbuncle swells furunculosis, acute appendicitis abdomen
Bitterly, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice urine is red, stranguria, oedema；Externally treating burns and scalds.Prepared RADIX ET RHIZOMA RHEI with wine is apt to
Clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI rushes down exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Greatly
Yellow charcoal cooling blood and removing stasis hemostasis.There is stasis of blood haemorrhage for blood-head.
Rhizoma atractylodis：Perennial herb.Stem list is given birth to or fasciation, and stem branch is dredged by arachnoid hair.Rhizoma atractylodis root-like stock is used as medicine, have eliminating dampness,
Change the effect of turbid, analgesic.
The Radix Astragali：《Compendium of Materia Medica》In also known as wearing crushed grain, wear mulberry, grass, hundred, the prince's descendants, (" stilbene " original work are " over sixty years of age ")；Smell
(root) is sweet, tepor, nontoxic；Cure mainly:Urinary obstruction, wine subcutaneous ulcer Huang disease, gonorrhoea, sallow terribly thirsty, old people constipation, blood strangury, drench less, tell
Blood, cough purulence hemoptysis, lung carbuncle, fetal irritability, the moon and make soaked with sweat and itch.Have tonifying middle-Jiao and Qi arrest sweating, control chronic nephritis, the albumen that disappears, solution taking poison and growing muscle due,
The effects such as strengthening the spleen and stomach.The Chinese medicine Radix Astragali is leguminous herbaceous plant's astragalus mongolicus, the root of Astragalus membranacus, with invigorating qi for strengthening superficies, profit
The effects such as water detumescence, pus draining and toxin expelling, myogenic；The Radix Astragali is more containing saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper etc.
Plant trace element；There are enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, step-down and wide antibacterial action.
Dark plum：Almost ripe fruit is dried for rose department plant plum.For chronic cough of deficiency lung, protracted dysentery and diarrhea, abnormal heat is quenched one's thirst, ascarid
Vomiting of fainting is suffered from abdominal pain.
Cordate houttuynia：Cordate houttuynia is the herbal medicine that Chinese Pharmacopoeia is included, herbal medicine source be saururaceae plant houttuynia cordata dryly
Upper part.It is clearing heat and detoxicating, inducing diuresis to remove edema.Pneumonia is controlled, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid take off
Anus, eczema, the favus of the scalp, mange.
Golden cypress:It is the dry bark of rutaceae wampee.Practise and claim " CORTEX PHELLODENDRI CHINENSE ".After stripping bark, tertia is removed,
Dry.For damp-heat dysentery, jaundice urine is red, under band pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted, hectic fever due to yin labor heat, night sweat, seminal emission, sore
Pyogenic infections, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Radix Isatidis:Alias：Indigo-blue, indigo root, manyflower glorybower root, are a kind of Chinese medicines.It is doing for cruciferae isatis
Dry, generally excavated in the fall, can be used as medicine after processing.Its is cold in nature, and taste is first micro- sweet rear pained, with clearing heat and detoxicating, prevention
The effect of flu, relieving sore-throat.It is mainly used in the diseases such as the dark reddish purple dark, scarlet fever for the treatment of febrile virulent maculae, tongue.
Each material combination does not exist incompatibility in medicine of the invention, the incidence of dfuck cholera can be substantially reduced, to duck
Cholera has good preventive and therapeutic action, and has no toxic side effect, using safety, without hazardous drugs residual.
Medicine application method of the invention:During nursing, every 500 kg diet weighs 2000-2200 grams for the treatment of and prevention duck
The medicine of cholera, then by the medicine with appropriate water to mixing up, be subsequently adding in feed, mix, feed immediately, it is sooner or later each daily
Feed once, 10 days is a course for the treatment of, and one course for the treatment of of this medicine can be fed every 20 days.
In order to illustrate more clearly of the present invention, following examples are enumerated, but its scope to invention is without any restrictions.
Specific embodiment
Embodiment 1
Weigh wrinkled giant hyssop 200g, coptis 180g, rheum officinale 200g, rhizoma atractylodis 300g, Radix Astragali 150g, dark plum 360g, cordate houttuynia 200g, golden cypress
200g, Radix Isatidis 300g, these material compositions are the quality after drying, and 150-300 mesh is ground into micronizer,
It is well mixed, then packed with plastic bag sealing, the medicine for treating and preventing dfuck cholera is obtained.
Application method：When feeding every time, every 500 kilograms of feeds for mixing up weigh 2090 grams of the present embodiment preventing and treating duckling wounds
Cold medicine, then by the medicine with appropriate water to mixing up, be subsequently adding in feed, mix, feed immediately, daily sooner or later respectively feed
Support once, 10 days is a course for the treatment of, and one course for the treatment of of this medicine can be fed every 20 days.
Embodiment 2-14, comparative example 1-2
Embodiment 2-12 its raw material type and step of preparation process and is used in addition to raw material mass mixture ratio is different from embodiment 1
Method is identical with embodiment 1, and comparative example 1 is that cordate houttuynia is eliminated on the basis of embodiment 1, and comparative example 2 is in embodiment 1
On the basis of eliminate rhizoma atractylodis, raw material that embodiment 1-12, comparative example 1-2 are used and quality as shown in Table 1 below, below
Table 1 show raw material and quality that embodiment 1-12, comparative example 1-2 used.
Table 1
Clinical practice one：
Hengyang duckery, the 95 age in days sheldrakes morbidity of raising, spirit is depressed, and tail fin is sagging, closes one's eyes slow-witted vertical, the fluffy and disorderly nothing of feather
Light；Poor appetite is useless exhausted, and drink is intended to increase；42-43 DEG C of body temperature；Mouth and nose flow out mucus, and mouth breathing is shaken the head；Under acutely
Dysentery, row's green or white loose stool；Duck is preced with and wattle is blue, and dfuck cholera is judged to by clinical and laboratory diagnosis.Select 600
Sick duck, 15 groups are randomly divided into by sick duck, every group 40, are controlled with embodiment 1-12, the made medicines of comparative example 1-2 and terramycin respectively
Treat（Control group）Treated, after medication 10 days, got well using the duck group more than 95% of made drug therapy of the invention, soil
The duck group 70% of mycin treatment group treatment gets well, as a result such as table 2：
Table 2
By table 2 as can be seen that medicine of the invention has significant therapeutic effect to dfuck cholera, cure rate is treated higher than terramycin
Group.
Clinical practice two：
In order to prove feeding effect of the present invention to duck, feeding experiment is repeatedly tried in the duck field occurred in epidemic situation, chooses large-scale
600 ducklings of duckery, body weight size, health status are basically identical, are randomly divided into 15 groups, every group 40.Wherein 14 groups are
Experimental group, the feed that feeding embodiment 1-12, medicine described in comparative example 1-2 are made into respectively, twice daily, continuous 10 days, every
Feed a course for the treatment of within 20 days.Another group is control group, and feeding is not added with the identical feed of medicine, 15 groups of nursing number of times of duckling, is fed
Support amount, nursing time all same.Contrast 15 groups of various performance indications of duckling, average value such as table 3.
After 40 days, 15 groups of duckling situation such as tables 3：
Table 3
Can be evident that from table, after the feed that the continuous feeding present invention is provided, weightening is relatively compareed experimental group duckling
Group increases obvious, and experimental group duckling is compared with control group honey stomach, and energetic, state is good, occurs without dfuck cholera disease.
So the present invention is not limited to as the protective agents of dfuck cholera, as long as composition of raw materials it is identical with the present invention or
Equivalent medicine just falls within the scope and spirit of the invention.By with the protective agents same recipe for preventing and treating dfuck cholera of the invention
Raw material be made any Chinese medicine preparation and also fall within the scope and spirit of the invention, as long as i.e. composition of raw materials and phase of the present invention
Same medicine just falls within the scope and spirit of the invention.
Claims (9)
1. it is a kind of treat and prevent dfuck cholera medicine, it is characterised in that be made up by the bulk drug that part matches of following weight：The leaves of pulse plants
Fragrant 190-215 parts, coptis 170-200 parts, rheum officinale 190-215 parts, rhizoma atractylodis 280-320 parts, Radix Astragali 140-165 parts, dark plum 350-
380 parts, cordate houttuynia 180-215 parts, golden cypress 190-215 parts, Radix Isatidis 290-320 parts.
2. it is according to claim 1 treat and prevent dfuck cholera medicine, it is characterised in that wrinkled giant hyssop 190-210 parts, the coptis
170-195 parts, rheum officinale 190-210 parts, rhizoma atractylodis 280-315 parts, Radix Astragali 140-160 parts, dark plum 350-375 parts, cordate houttuynia 180-
210 parts, golden cypress 190-210 parts, Radix Isatidis 290-315 parts.
3. it is according to claim 1 treat and prevent dfuck cholera medicine, it is characterised in that wrinkled giant hyssop 190-205 parts, the coptis
170-190 parts, rheum officinale 190-205 parts, rhizoma atractylodis 290-315 parts, Radix Astragali 140-155 parts, dark plum 350-370 parts, cordate houttuynia 190-
210 parts, golden cypress 190-205 parts, Radix Isatidis 290-310 parts.
4. it is according to claim 1 treat and prevent dfuck cholera medicine, it is characterised in that wrinkled giant hyssop 190-200 parts, the coptis
170-190 parts, rheum officinale 190-200 parts, rhizoma atractylodis 290-310 parts, Radix Astragali 145-155 parts, dark plum 350-365 parts, cordate houttuynia 195-
210 parts, golden cypress 195-205 parts, Radix Isatidis 290-305 parts.
5. it is according to claim 1 treat and prevent dfuck cholera medicine, it is characterised in that wrinkled giant hyssop 195-200 parts, the coptis
180-190 parts, rheum officinale 195-200 parts, rhizoma atractylodis 300-310 parts, Radix Astragali 145-150 parts, dark plum 350-360 parts, cordate houttuynia 200-
210 parts, golden cypress 195-200 parts, Radix Isatidis 300-305 parts.
6. it is according to claim 1 treat and prevent dfuck cholera medicine, it is characterised in that 200 parts of wrinkled giant hyssop, the coptis 180
Part, 200 parts of rheum officinale, 300 parts of rhizoma atractylodis, 150 parts of the Radix Astragali, 360 parts of dark plum, 200 parts of cordate houttuynia, 200 parts of golden cypress, 300 parts of Radix Isatidis.
7. the preparation method of the medicine of dfuck cholera is treated and prevented according to claim 1, it is characterized in that：It is mainly included such as
Lower step：
First, bulk drug is weighed；
2nd, the bulk drug that will claim is crushed, and is well mixed, and obtains medical treatment and prevent the medicine of dfuck cholera.
8. the preparation method of the medicine of dfuck cholera is treated and prevented according to claim 7, it is characterized in that：Step 2 raw material powder
After broken, 300 mesh sieves are crossed.
9. it is according to claim 7 treat and prevent dfuck cholera medicine preparation method, it is characterized in that：Step 2 raw material
After crushing, 200 mesh sieves are crossed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611223428.8A CN106692431A (en) | 2016-12-27 | 2016-12-27 | Medicine for treating and preventing duck cholera and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611223428.8A CN106692431A (en) | 2016-12-27 | 2016-12-27 | Medicine for treating and preventing duck cholera and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106692431A true CN106692431A (en) | 2017-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611223428.8A Withdrawn CN106692431A (en) | 2016-12-27 | 2016-12-27 | Medicine for treating and preventing duck cholera and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815280A (en) * | 2018-08-09 | 2018-11-16 | 集美大学 | A kind of Chinese medicine composition and its preparation method and application deforming pseudomonad disease for treating grouper |
-
2016
- 2016-12-27 CN CN201611223428.8A patent/CN106692431A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108815280A (en) * | 2018-08-09 | 2018-11-16 | 集美大学 | A kind of Chinese medicine composition and its preparation method and application deforming pseudomonad disease for treating grouper |
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