CN111150875B - Hydrogel for indwelling needle application and preparation method thereof - Google Patents

Hydrogel for indwelling needle application and preparation method thereof Download PDF

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CN111150875B
CN111150875B CN202010090651.XA CN202010090651A CN111150875B CN 111150875 B CN111150875 B CN 111150875B CN 202010090651 A CN202010090651 A CN 202010090651A CN 111150875 B CN111150875 B CN 111150875B
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万思疑
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Tongji Medical College of Huazhong University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties

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Abstract

The invention provides a hydrogel for indwelling needle application, which comprises the following components in parts by weight: polyethylene glycol: 20-30 parts of a solvent; polyglutamic acid: 3.2-5.5 parts; tannic acid: 2.4-7.0 parts; succinaldehyde: 1.2-2.4 parts; hyaluronic acid: 0.7-5.0 parts; deionized water: 200-360 parts; an acidity regulator; wherein the acidic regulator is used for regulating pH. The hyaluronic acid content is added and optimized, so that the hyaluronic acid has better adsorption capacity and water retention property, and the skin at the position of application can be nursed. The invention also provides a preparation method of the hydrogel for the indwelling needle application, which is used for preparing the hydrogel for the indwelling needle application with better adsorption force and water retention by adding and optimizing the content of hyaluronic acid and accurately controlling the reaction temperature, stirring speed and standing time.

Description

Hydrogel for indwelling needle application and preparation method thereof
Technical Field
The invention relates to the technical field of preparation of indwelling needle application, in particular to hydrogel for the indwelling needle application and a preparation method thereof.
Background
Patients who are fasted for a long time need to be infused with nutrient solutions such as amino acid, fat emulsion and the like, phlebitis can occur in the infusion process, the retention time of an indwelling needle is short, and repeated puncture damages blood vessels of the patients. The application of the hydrogel patch can reduce phlebitis and prolong the use time of an indwelling needle.
Chinese patent 201010140046.5 discloses a low-swelling hydrogel with swelling degree of about-50% to about 50%, but the raw material used in this patent is trilysine, which is expensive, and the low-swelling hydrogel is alkaline, and if the dressing is alkaline, it will cause severe irritation to the surrounding skin.
The Chinese patent invention 201811170048.1 discloses a medical silicone gel dressing patch, which comprises a hydrophobic layer, a medical non-woven fabric layer, a pressure-sensitive adhesive layer and a plasma layer, wherein the hydrophobic layer, the medical non-woven fabric layer, the pressure-sensitive adhesive layer and the plasma layer are sequentially arranged from outside to inside, a silicone gel layer with a preset area is arranged between the medical non-woven fabric layer and the pressure-sensitive adhesive layer, and the silicone gel dressing is prepared from 45-60% of silicone, 1-8% of medical emulsifier and 32-54% of matrix in percentage by mass. However, the silicone gel has poor tissue integration, namely, the silicone gel is not tightly attached to the tissue, and cannot play a role in actively promoting wound repair, and the gel is easy to dehydrate in the air to cause structural damage and reduce the efficacy.
Disclosure of Invention
The invention aims to design and develop a hydrogel for indwelling needle application, which is added and optimized in hyaluronic acid content, so that the hydrogel has good adsorption force and water retention property and can be used for nursing the skin at the application position.
The invention also aims to design and develop a preparation method of the hydrogel for the indwelling needle application, which is used for preparing the hydrogel for the indwelling needle application with better adsorption force and water retention by adding and optimizing the content of hyaluronic acid and accurately controlling the reaction temperature, stirring speed and standing time.
The technical scheme provided by the invention is as follows:
the hydrogel for the indwelling needle application comprises the following components in parts by weight:
polyethylene glycol: 20-30 parts of a solvent;
polyglutamic acid: 3.2-5.5 parts;
tannic acid: 2.4-7.0 parts;
succinaldehyde: 1.2-2.4 parts;
hyaluronic acid: 0.7-5.0 parts;
deionized water: 200-360 parts;
an acidity regulator;
wherein the acidic regulator is used for regulating pH.
Preferably, the hyaluronic acid comprises the following components in parts by weight:
Figure BDA0002383589790000021
wherein, whyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight fraction of polyglutamic acid, wetThe weight portion of the polyethylene glycol.
Preferably, the acidity regulator is a mixed solution of hydrochloric acid and tartaric acid.
Preferably, the molar ratio of the hydrochloric acid to the tartaric acid in the mixed solution of hydrochloric acid and tartaric acid is 2: 1.
preferably, the mass concentration of the succinaldehyde is 5-10%.
A preparation method of hydrogel for indwelling needle application comprises the following steps:
step 1: adding polyethylene glycol into deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 80-90 ℃;
wherein the weight part of the polyethylene glycol is 20-30 parts, and the weight part of the deionized water is 200-360 parts;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH of the solution to 3-4, adding polyglutamic acid and tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000031
in the formula, T2Heating the solution in the step 2; t is1Heating the solution in the step 1;
wherein the weight portion of the polyglutamic acid is 3.2-5.5, and the weight portion of the tannic acid is 2.4-7.0;
and step 3: adding succinaldehyde and hyaluronic acid, stirring at room temperature for 20-30 min, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000032
the rest time satisfies:
Figure BDA0002383589790000033
in the formula, n3The stirring speed of step 3, n2The stirring speed of step 2, n1The stirring speed in the step 1 is T is room temperature, T0To set the temperature, ηbuIs the viscosity, eta, of succinaldehydehyIs the viscosity, eta, of hyaluronic acidmViscosity, w, of the solution obtained for step 2hyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight fraction of polyglutamic acid, wetIs the weight portion of polyethylene glycol, t is the rest time, t0Is a set time and t0＝20min；
Wherein the weight portion of the succinaldehyde is 1.2-2.4, and the weight portion of the hyaluronic acid is 0.7-5.0.
Preferably, in the step 3, the hyaluronic acid comprises the following components in parts by weight:
Figure BDA0002383589790000041
preferably, the acidity regulator is a mixed solution of hydrochloric acid and tartaric acid.
Preferably, the molar ratio of the hydrochloric acid to the tartaric acid in the mixed solution of hydrochloric acid and tartaric acid is 2: 1.
preferably, the mass concentration of the succinaldehyde is 5-10%.
The invention has the following beneficial effects:
(1) the hydrogel for the indwelling needle application designed and developed by the invention is added and optimized in hyaluronic acid content, so that the hydrogel has good adsorption capacity and water retention property, and can be used for nursing the skin at the application position.
(2) The preparation method of the hydrogel for the indwelling needle application designed and developed by the invention is used for preparing the hydrogel for the indwelling needle application with better adsorption capacity and water retention property by adding and optimizing the content of hyaluronic acid and accurately controlling the reaction temperature, the stirring speed and the standing time.
Drawings
FIG. 1 is a water retention property graph of a hydrogel for indwelling needle application prepared in example 3 of the present invention at 40 ℃.
FIG. 2 is a water retention curve at ordinary temperature of a hydrogel for indwelling needle application prepared in example 3 of the present invention.
Detailed Description
The present invention is further described in detail below with reference to the attached drawings so that those skilled in the art can implement the invention by referring to the description text.
This invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather as being provided for the purpose of illustration and description.
The invention provides a hydrogel for indwelling needle application, which comprises the following components in parts by weight: polyethylene glycol: 20-30 parts of a solvent; polyglutamic acid: 3.2-5.5 parts; tannic acid: 2.4-7.0 parts; succinaldehyde: 1.2-2.4 parts; hyaluronic acid: 0.7-5.0 parts; deionized water: 200-360 parts; an acidity regulator; wherein the acidic regulator is used for regulating pH.
The hyaluronic acid comprises the following components in parts by weight:
Figure BDA0002383589790000051
wherein, whyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight fraction of polyglutamic acid, wetThe weight portion of the polyethylene glycol.
The acidity regulator is a mixed solution of hydrochloric acid and tartaric acid, and the molar ratio of the hydrochloric acid to the tartaric acid is 2: 1. the mass concentration of the butanedialdehyde is 5-10%.
The hydrogel for the indwelling needle application designed and developed by the invention is added and optimized in hyaluronic acid content, so that the hydrogel has good adsorption capacity and water retention property, and can be used for nursing the skin at the application position.
The invention also provides a preparation method of the hydrogel for the indwelling needle application, which comprises the following steps:
step 1: adding polyethylene glycol into deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 80-90 ℃;
wherein the weight part of the polyethylene glycol is 20-30 parts, and the weight part of the deionized water is 200-360 parts;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH of the solution to 3-4, adding polyglutamic acid and tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000052
in the formula, T2Heating the solution in the step 2; t is1Heating the solution in the step 1;
wherein, the weight portion of the polyglutamic acid is 3.2 to 5.5 portions, and the weight portion of the tannic acid is 2.4 to 7.0 portions;
and step 3: adding succinaldehyde and hyaluronic acid, stirring at room temperature for 20-30 min, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000061
the rest time satisfies:
Figure BDA0002383589790000062
in the formula, n3The stirring speed of step 3, n2The stirring speed of step 2, n1The stirring speed in the step 1 is T is room temperature, T0To set the temperature, ηbuIs the viscosity, eta, of succinaldehydehyIs the viscosity, eta, of hyaluronic acidmViscosity, w, of the solution obtained for step 2hyIs the weight portion of hyaluronic acid, wbuIs prepared from Butylene glycolWeight fraction of aldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight fraction of polyglutamic acid, wetIs the weight portion of polyethylene glycol, t is the rest time, t0Is a set time and t0＝20min；
Wherein the weight portion of the succinaldehyde is 1.2-2.4, and the weight portion of the hyaluronic acid is 0.7-5.0.
In the step 3, the weight parts of the hyaluronic acid further satisfy that:
Figure BDA0002383589790000063
the acidity regulator is a mixed solution of hydrochloric acid and tartaric acid, and the molar ratio of the hydrochloric acid to the tartaric acid is 2: 1. the mass concentration of the butanedialdehyde is 5-10%.
Example 1
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 20 parts of (1); polyglutamic acid: 3.2 parts of a mixture; tannic acid: 2.4 parts; succinaldehyde: 1.2 parts; deionized water: 200 parts of (A);
hyaluronic acid:
Figure BDA0002383589790000071
the preparation process comprises the following steps:
step 1: adding 20 parts of polyethylene glycol into 200 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 80 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3, adding 3.2 parts of polyglutamic acid and 2.4 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000072
and step 3: adding 1.2 parts of succinaldehyde and 0.74 part of hyaluronic acid, stirring for 20min at room temperature, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000073
the rest time satisfies:
Figure BDA0002383589790000074
example 2
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 30 parts of (1); polyglutamic acid: 5.5 parts; tannic acid: 7.0 parts; succinaldehyde: 2.4 parts; deionized water: 360 parts of a mixture;
hyaluronic acid:
Figure BDA0002383589790000075
the preparation process comprises the following steps:
step 1: adding 30 parts of polyethylene glycol into 360 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 90 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 4, adding 5.5 parts of polyglutamic acid and 7.0 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000081
and step 3: adding 2.4 parts of succinaldehyde and 4.3 parts of hyaluronic acid, stirring for 30min at room temperature, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000082
the rest time satisfies:
Figure BDA0002383589790000083
example 3
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 25 parts of (1); polyglutamic acid: 4.5 parts; tannic acid: 5.0 parts of (B); succinaldehyde: 2.0 parts of (B); deionized water: 290 parts of (a);
hyaluronic acid:
Figure BDA0002383589790000084
the preparation process comprises the following steps:
step 1: adding 25 parts of polyethylene glycol into 290 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 85 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3.5, adding 4.5 parts of polyglutamic acid and 5.0 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000091
and step 3: adding 2.0 parts of succinaldehyde and 3.7 parts of hyaluronic acid, stirring at room temperature for 25min, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000092
the rest time satisfies:
Figure BDA0002383589790000093
example 4
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 28 parts of (1); polyglutamic acid: 4 parts of a mixture; tannic acid: 5.5 parts; succinaldehyde: 2.2 parts of; deionized water: 286 parts of;
hyaluronic acid:
Figure BDA0002383589790000094
the preparation process comprises the following steps:
step 1: adding 28 parts of polyethylene glycol into 286 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 85 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3.5, adding 4.0 parts of polyglutamic acid and 5.5 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000095
and step 3: adding 2.2 parts of succinaldehyde and 3.8 parts of hyaluronic acid, stirring at room temperature for 25min, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure BDA0002383589790000101
the rest time satisfies:
Figure BDA0002383589790000102
comparative example 1
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 28 parts of (1); polyglutamic acid: 4 parts of a mixture; tannic acid: 5.5 parts; succinaldehyde: 2.2 parts of; deionized water: 286 parts of;
the preparation process comprises the following steps:
step 1: adding 28 parts of polyethylene glycol into 286 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 85 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3.5, adding 4.0 parts of polyglutamic acid and 5.5 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000103
and step 3: adding 2.2 parts of succinaldehyde, stirring at room temperature for 25min, and standing for 75min (controlling the stirring speed to be 538r/min) to obtain hydrogel;
comparative example 2
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 25 parts of (1); polyglutamic acid: 4.5 parts; tannic acid: 5.0 parts of (B); succinaldehyde: 2.0 parts of (B); deionized water: 290 parts of (a); and 7 parts of hyaluronic acid.
The preparation process comprises the following steps:
step 1: adding 25 parts of polyethylene glycol into 290 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 85 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3.5, adding 4.5 parts of polyglutamic acid and 5.0 parts of tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure BDA0002383589790000111
and step 3: adding 2.0 parts of succinaldehyde and 7 parts of hyaluronic acid, stirring at room temperature for 25min, and standing for 66min (controlling the stirring speed at 541r/min) to obtain hydrogel.
Comparative example 3
The components and parts by weight of the hydrogel for indwelling needle application of the present embodiment are: polyethylene glycol: 25 parts of (1); polyglutamic acid: 4.5 parts; tannic acid: 5.0 parts of (B); succinaldehyde: 2.0 parts of (B); deionized water: 290 parts of (a); hyaluronic acid: 0.5 part.
The preparation process comprises the following steps:
step 1: adding 25 parts of polyethylene glycol into 290 parts of deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 85 ℃;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH value of the solution to 3.5, adding 4.5 parts of polyglutamic acid and 5.0 parts of tannic acid, heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved, and controlling the heating temperature to be 50 ℃;
and step 3: adding 2.0 parts of succinaldehyde and 0.5 part of hyaluronic acid, stirring at room temperature for 25min, and standing for 50min (stirring speed is controlled at 520r/min) to obtain hydrogel.
The hydrogel for indwelling needle application prepared in examples 1 to 4 and comparative examples 1 to 3 was subjected to measurement of initial peel strength of skin, skin tack retention, and water retention at room temperature for 6 hours by the orthogonal test method, and the results are shown in Table 1.
TABLE 1 test results
Serial number Initial peel strength of skin Degree of skin tack retention Water retention property
Example 1 0.04/0.5kg Can be applied to skin and thrown for 8 times without dropping 91％
Example 2 0.06/0.5kg Can be applied to skin and thrown for 9 times 90％
Example 3 0.05/0.5kg Can be applied to skin and thrown for 10 times 92％
Example 4 0.06/0.5kg Can be applied to skin and thrown for 9 times 91％
Comparative example 1 0.02/0.5kg Can be applied to skin and thrown for 3 times without dropping 79％
Comparative example 2 0.03/0.5kg Can be applied to skin and thrown for 5 times without dropping 82％
Comparative example 3 0.02/0.5kg Can be applied to skin and thrown for 4 times without dropping 81％
As is clear from Table 1, the hydrogel for indwelling needle application prepared according to the present invention has high initial peel strength of skin, skin tack retaining ability, and water retentivity.
The hydrogel for indwelling needle application prepared in example 3 was selected for water retention test as shown in FIGS. 1 and 2. The hydrogel for indwelling needle application prepared in example 3 showed the fastest decrease in water retention for the first 15 hours at 40 ℃ (shown in fig. 1), the decrease in water retention was gradual for 15 to 20 hours, and after 28 hours, the water retention was about 28.6%. Under the condition of normal temperature (shown in figure 2), the water retention property of the hydrogel is reduced fastest within 15-40 hours, then the water retention property is continuously reduced, the reduction speed is slow, the water retention property of the hydrogel is 37.9% within 48 hours,
the preparation method of the hydrogel for the indwelling needle application designed and developed by the invention is used for preparing the hydrogel for the indwelling needle application with better adsorption capacity and water retention property by adding and optimizing the content of hyaluronic acid and accurately controlling the reaction temperature, the stirring speed and the standing time.
When the hydrogel patch is used, a common patch can be used, a through hole is formed in the center of the patch, the hydrogel prepared by the invention is arranged in the through hole, the position of the hydrogel enables an indwelling needle to penetrate through, and the hydrogel corresponds to the skin of a needle eye, so that phlebitis can be effectively avoided, the use of the hydrogel is saved, and the cost is greatly reduced.
While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable in various fields of endeavor to which the invention pertains, and further modifications may readily be made by those skilled in the art, it being understood that the invention is not limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.

Claims (8)

1. The hydrogel for the indwelling needle application is characterized by comprising the following components in parts by weight:
polyethylene glycol: 20-30 parts of a solvent;
polyglutamic acid: 3.2-5.5 parts;
tannic acid: 2.4-7.0 parts;
succinaldehyde: 1.2-2.4 parts;
hyaluronic acid: 0.7-5.0 parts;
deionized water: 200-360 parts;
an acidity regulator;
wherein the acidic regulator is used for regulating the pH;
the hyaluronic acid comprises the following components in parts by weight:
Figure FDA0003191970660000011
wherein, whyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight portion of polyglutamic acid, wetThe weight portion of the polyethylene glycol.
2. The hydrogel for indwelling needle application according to claim 1, wherein the acidity regulator is a mixed solution of hydrochloric acid and tartaric acid.
3. The hydrogel for indwelling needle application according to claim 2, wherein the molar ratio of hydrochloric acid to tartaric acid in the mixed solution of hydrochloric acid and tartaric acid is 2: 1.
4. the hydrogel for indwelling needle application according to claim 3, wherein the concentration by mass of succinaldehyde is 5 to 10%.
5. A preparation method of hydrogel for indwelling needle application is characterized by comprising the following steps:
step 1: adding polyethylene glycol into deionized water, heating and stirring until the polyethylene glycol is completely dissolved, wherein the heating temperature is 80-90 ℃;
wherein the weight part of the polyethylene glycol is 20-30 parts, and the weight part of the deionized water is 200-360 parts;
step 2: adding an acidic regulator into the solution obtained in the step 1, regulating the pH of the solution to 3-4, adding polyglutamic acid and tannic acid, and heating and stirring until the polyglutamic acid and the tannic acid are completely dissolved;
controlling the heating temperature to meet the following requirements:
Figure FDA0003191970660000021
in the formula, T2Heating the solution in the step 2; t is1Heating the solution in the step 1;
wherein the weight portion of the polyglutamic acid is 3.2-5.5, and the weight portion of the tannic acid is 2.4-7.0;
and step 3: adding succinaldehyde and hyaluronic acid, stirring at room temperature for 20-30 min, and standing to obtain hydrogel;
controlling the stirring speed to meet the following requirements:
Figure FDA0003191970660000022
the rest time satisfies:
Figure FDA0003191970660000023
in the formula, n3The stirring speed of step 3, n2The stirring speed of step 2, n1The stirring speed in the step 1 is T is room temperature, T0To set the temperature, ηbuIs the viscosity, eta, of succinaldehydehyIs the viscosity, eta, of hyaluronic acidmViscosity, w, of the solution obtained for step 2hyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight portion of polyglutamic acid, wetIs the weight portion of polyethylene glycol, t is the rest time, t0Is a set time and t0＝20min；
Wherein the weight portion of the succinaldehyde is 1.2-2.4, and the weight portion of the hyaluronic acid is 0.7-5.0;
the hyaluronic acid comprises the following components in parts by weight:
Figure FDA0003191970660000031
wherein, whyIs the weight portion of hyaluronic acid, wbuIs the weight part of succinaldehyde, wwaIs the weight part of deionized water, wgaThe weight portion of the tannic acid is; w is aglIs the weight portion of polyglutamic acid, wetThe weight portion of the polyethylene glycol.
6. The method for preparing a hydrogel for indwelling needle application according to claim 5, wherein the acidity regulator is a mixture of hydrochloric acid and tartaric acid.
7. The method for preparing a hydrogel for indwelling needle application according to claim 6, wherein the molar ratio of hydrochloric acid to tartaric acid in the mixed solution of hydrochloric acid and tartaric acid is 2: 1.
8. the method for preparing the hydrogel for indwelling needle application according to claim 7, wherein the mass concentration of succinaldehyde is 5 to 10%.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103611184A (en) * 2013-11-27 2014-03-05 长春吉原生物科技有限公司 Hydrogel of composite semipermeable membrane and preparation method thereof
CN204468878U (en) * 2015-01-29 2015-07-15 云南省玉溪市人民医院 Venous detaining needle protection system
CN106267316A (en) * 2016-08-18 2017-01-04 南京轩凯生物科技有限公司 A kind of anti-dehydration Gekko Swinhonis hydrogel application and preparation method thereof
CN107137760A (en) * 2017-05-27 2017-09-08 河南汇博医疗股份有限公司 A kind of moisturizing maintenance dressing and preparation method thereof
CN209033363U (en) * 2018-06-27 2019-06-28 杭州市第一人民医院 A kind of remaining needle plaster

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103611184A (en) * 2013-11-27 2014-03-05 长春吉原生物科技有限公司 Hydrogel of composite semipermeable membrane and preparation method thereof
CN204468878U (en) * 2015-01-29 2015-07-15 云南省玉溪市人民医院 Venous detaining needle protection system
CN106267316A (en) * 2016-08-18 2017-01-04 南京轩凯生物科技有限公司 A kind of anti-dehydration Gekko Swinhonis hydrogel application and preparation method thereof
CN107137760A (en) * 2017-05-27 2017-09-08 河南汇博医疗股份有限公司 A kind of moisturizing maintenance dressing and preparation method thereof
CN209033363U (en) * 2018-06-27 2019-06-28 杭州市第一人民医院 A kind of remaining needle plaster

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