CN107136269A - A kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof - Google Patents
A kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The present invention relates to a kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof.The blue or green money willow bitter gourd sugar-reducing tea is made by the raw material of following parts by weight：1 20 parts of Qingqian Willow leaf, 40 80 parts of balsam pear class, 1 15 parts of mulberry leaf, 1 15 parts of selfheal, 1 10 parts of chrysanthemum indicum, 15 parts of jasmine tea；Wherein, the balsam pear class is the combination of Bitter Melon P.E, balsam pear jerky or balsam pear jerky and Bitter Melon P.E.The raw materials used present invention is integration of drinking and medicinal herbs, is had no toxic side effect；There is preferable adjuvant treatment effect to type II diabetes, the consumption per day of medicine can be reduced to 2nd/1 to three/2nds of former dosage, have no adverse reaction, effectively reduce side effects of pharmaceutical drugs.
Description
Technical field
The present invention relates to a kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof, belong to medical health care tea.
Background technology
Diabetes (diabetes) are by inherent cause, immunologic function disorder, microorganism infection and its toxin, free radical poison
Element, the various virulence factors of mental element etc. act on the sugar that body causes hypoinsulinism, insulin resistance etc. and trigger,
A series of metabolic disorder syndromes such as protein, fat, water and electrolyte.
At present, the medicine for the treatment of diabetes has insulin and oral hypoglycemic, and oral hypoglycemic includes sulfonylureas, double
Guanidine, benzoic acid derivative, alpha-glucosidase inhibitor, thiazolidinediones.But it is serious that current medicine all has some
Side reaction.
The content of the invention
The present invention provides a kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof, can be with insulin or all kinds of oral drop blood
Sugared medicine is used in combination, assisting in reducing blood sugar, the effect for having preferable assisting in reducing blood sugar especially for type II diabetes early stage,
The dosage of insulin or all kinds of oral hypoglycemics is reduced, so as to reduce the side effect that medicine is brought.It is described that there is reduction
The preparation method of the composition of blood glucose effect has technique simple, and cost is low, the characteristics of being conducive to industrialized production.
To achieve the above object, the present invention is adopted the following technical scheme that：
A kind of blue or green money willow bitter gourd sugar-reducing tea, is made by the raw material of following parts by weight：1-20 parts of Qingqian Willow leaf, balsam pear class 40-
80 parts, 1-15 parts of mulberry leaf, 1-15 parts of selfheal, 1-10 parts of chrysanthemum indicum, 1-5 parts of jasmine tea；
Wherein, the balsam pear class is the combination of Bitter Melon P.E, balsam pear jerky or balsam pear jerky and Bitter Melon P.E；
Preferably, in the combination of the balsam pear jerky and Bitter Melon P.E, the weight ratio of the Bitter Melon P.E and balsam pear jerky is
1：7-9；Preferably 1：8.5.
The Bitter Melon P.E is extracted from balsampear leaf, balsampear stem and balsam pear jerky and obtained；Wherein, the balsam pear
Leaf：Balsampear stem：The mass ratio of balsam pear jerky is (1-6):(1-4):(2-10)；It is highly preferred that when the blue or green money willow bitter gourd sugar-reducing
When tea is tea bag, the balsampear leaf：Balsampear stem：The mass ratio of balsam pear jerky is 3:3:4；When the blue or green money willow bitter gourd sugar-reducing tea
During for granule, the balsampear leaf：Balsampear stem：The mass ratio of balsam pear jerky is 1:1:6.
The Bitter Melon P.E is comprised the following steps：The balsampear leaf for the ratio for preparing, balsampear stem and balsam pear jerky are crushed
Into 10-30 mesh particles, 1-20 times of 50%-90% ethanol is added, adjustment pH value to 6.0-8.0 extracts 6-10 small in 20 DEG C -50 DEG C
When, extract 2 times, filtering takes filtrate；1-10 times of 50%-90% ethanol is added, adjustment pH value is to 6.0-8.0, in 20 DEG C -50
DEG C extract 6-10 hour, filter, take filtrate；Merge three filtrates, be concentrated in vacuo to relative density (preferably relative for 1.05-1.2
Density is 1.15), to obtain Bitter Melon P.E medicinal extract, dries, produces Bitter Melon P.E.
The jasmine tea is derived from the one or more in jasmine tea, osmanthus flower tea, chrysanthemum tea or rose tea；Wherein described chrysanthemum
Chrysanthemum in jasmine tea is one kind in tire chrysanthemum, tribute chrysanthemum or FLOS CHRYSANTHEMI ALBA from Haizhou of China.
As one of preferred embodiment of the present invention, the blue or green money willow bitter gourd sugar-reducing tea is by including the original of following parts by weight
Material is made：5-20 parts of Qingqian Willow leaf, 45-80 parts of balsam pear class, 5-12 parts of mulberry leaf, 5-12 parts of selfheal, 1-10 parts of chrysanthemum indicum, jasmine tea
1-5 parts.
As one of preferred embodiment of the present invention, the blue or green money willow bitter gourd sugar-reducing tea is by including the original of following parts by weight
Material is made：6-12 parts of Qingqian Willow leaf, 70-80 parts of balsam pear class, 4-8 parts of mulberry leaf, 4-8 parts of selfheal, 3-5 parts of chrysanthemum indicum, jasmine tea 1-3
Part；Still more preferably, the blue or green money willow bitter gourd sugar-reducing tea is made by the raw material including following parts by weight：8 parts of Qingqian Willow leaf is bitter
Melon 76 parts, 5 parts of mulberry leaf, 5 parts of selfheal, 4 parts of chrysanthemum indicum, 2 parts of jasmine tea.
As one of preferred embodiment of the present invention, the blue or green money willow bitter gourd sugar-reducing tea is by including the original of following parts by weight
Material is made：15-20 parts of Qingqian Willow leaf, 40-50 parts of balsam pear class, 8-15 parts of mulberry leaf, 8-15 parts of selfheal, 8-10 parts of chrysanthemum indicum, flower
Tea 3-5 material are made：Still more preferably, the blue or green money willow bitter gourd sugar-reducing tea is made by the raw material including following parts by weight：Blue or green money
18 parts of willow leaf, 45 parts of balsam pear class, 11 parts of mulberry leaf, 11 parts of selfheal, 10 parts of chrysanthemum indicum, 5 parts of jasmine tea.Blue or green money willow of the present invention
Bitter gourd sugar-reducing tea has effect of lowering blood sugar, is used for convenience of consumer, present invention is alternatively directed to the specification of blue or green money willow bitter gourd sugar-reducing tea,
Formulation, packaging etc. are improved.It is preferred that the blue or green money willow bitter gourd sugar-reducing tea is made into granule or tea bag.
The present invention also provides the preparation technology of above-mentioned blue or green money willow bitter gourd sugar-reducing tea, is specially：By Qingqian Willow leaf, mulberry leaf, summer
Withered grass, chrysanthemum indicum, jasmine tea are mixed in proportion, balsam pear class can be mixed together according to final products dosage form selection and other raw materials or
After add, prepared according still further to the conventional fabrication process of formulation.
Wherein, the granule is comprised the following steps：By Qingqian Willow leaf, mulberry leaf, selfheal, chrysanthemum indicum, jasmine tea press than
Example weigh, respectively extract or mix after extract, gained total extract again with balsam pear class, food additives mixing granulation, sieve, dry
It is dry, sterilize, packaging, finished product.
Wherein, it is described to be packaged as plastics package；
The addition of the food additives is the 1/4-1/2 of total extract weight；The food additives are selected from methyl
Cellulose, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, oxidized starch, oxidation hydroxypropul starch, gelatin, carragheen or
One or more in sodium alginate.
As the preferred scheme of the process for producing granula, comprise the following steps：By the Qingqian Willow leaf for the ratio for preparing,
Mulberry leaf, selfheal, chrysanthemum indicum, Jasmine are ground into 10 mesh particles, add water to cook twice, collecting decoction, and filtration, filtrate decompression is dense
The medicinal extract that relative density is 1.2 is reduced to, with Bitter Melon P.E medicinal extract, methylcellulose mixing granulation, gained particle crosses 12 mesh sieves,
Drying, sterilizes, and packaging, finished product is described to be packaged as plastics package；The consumption of methylcellulose is the 1/ of raw extract gross weight
3。
The tea bag is then comprised the following steps：By Qingqian Willow leaf, balsam pear, mulberry leaf, selfheal, chrysanthemum indicum, jasmine tea
Mixing granulation in proportion, wherein balsam pear class are selected from Bitter Melon P.E and balsam pear jerky, and the two weight ratio is 1：8-9, gained particle
Sieving, is dried, and is sterilized, packaging, finished product；Wherein packaging is divided into inner packing and outer packing, and the inner packing uses non-woven fabrics, described
Outer packing uses plastics package.
The invention has the advantages that：
The present invention uses Qingqian Willow leaf, balsam pear class, mulberry leaf, selfheal, chrysanthemum indicum for primary raw material, is aided with jasmine tea regulation mouth
Taste, raw materials used is integration of drinking and medicinal herbs, and toxic side effect is small, can be ignored；To type II diabetes, especially for II type glycosuria
There is the effect of preferable assisting in reducing blood sugar sick early stage, and the consumption per day of medicine can be reduced to 1 to the three/2nds of former dosage
/ bis-, by the treatment of 12 weeks, have no adverse reaction, effectively reduce side effects of pharmaceutical drugs.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
A kind of blue or green money willow bitter gourd sugar-reducing tea (tea bag) of embodiment 1
A kind of blue or green money willow bitter gourd sugar-reducing tea, is made by following steps：
(1) balsampear leaf 142Kg, balsampear stem 142Kg, balsam pear jerky 189Kg are weighed, is well mixed, is ground into 10 mesh particles,
The ethanol of 5676Kg 60% is added, pH value 6.0 is adjusted, extracted 8 hours in 50 DEG C, filtering takes filtrate, is extracted altogether twice；Continue to
3784Kg85% ethanol is added in filter residue, pH value 7.0 is adjusted, extracted 6 hours in 50 DEG C, filtering takes filtrate, merges three filters
Liquid, it is 1.15 (50 DEG C of surveys) to be concentrated in vacuo to relative density, and obtaining Bitter Melon P.E medicinal extract 142.9Kg, (quality is after drying
80Kg)；
(2) Qingqian Willow leaf 80Kg, balsam pear jerky 680Kg, mulberry leaf 50Kg, selfheal 50Kg, chrysanthemum indicum 40Kg, jasmine are weighed
Flower 20Kg, is well mixed, is ground into 32 mesh particles, is mixed with Bitter Melon P.E medicinal extract 142.9Kg (quality is 80Kg after drying)
Uniformly, pelletize, gained particle crosses 12 mesh sieves, dry, sterilizing is fitted into non-woven fabrics inner packing, every bag of 5g, outer packing is plastics bag
Dress, finished product, totally 200000 bags.
A kind of blue or green money willow bitter gourd sugar-reducing tea (granule) of embodiment 2
A kind of blue or green money willow bitter gourd sugar-reducing tea, has the following steps obtained：
(1) balsampear leaf 145Kg, balsampear stem 145Kg, balsam pear jerky 870Kg are weighed, is well mixed, is ground into 10 mesh particles,
13920Kg60% ethanol is added, pH value 6.0 is adjusted, extracted 8 hours in 50 DEG C, filtering takes filtrate, is extracted altogether twice；Continue to
9280Kg85% ethanol is added in filter residue, pH value 7.0 is adjusted, extracted 6 hours in 50 DEG C, filtering takes filtrate, merges three filters
Liquid, it is 1.15 (50 DEG C of surveys) to be concentrated in vacuo to relative density, obtains Bitter Melon P.E medicinal extract 350Kg (quality is 196Kg after drying)；
(2) by Qingqian Willow leaf 78Kg, mulberry leaf 48Kg, selfheal 48Kg, chrysanthemum indicum 44Kg, Jasmine 22Kg is ground into 10 mesh
Particle, is added water to cook twice, and add water 2400Kg every time, 3 hours for the first time, and second 2 hours, collecting decoction, filtration, filtrate subtracted
Pressure is concentrated into the medicinal extract 240.4Kg (quality is 44Kg after drying) that relative density is 1.2 (80 DEG C of surveys), with Bitter Melon P.E medicinal extract
350Kg (quality is 196Kg after drying), methylcellulose 80Kg mixing granulations, gained particle crosses 12 mesh sieves, dries, and sterilizes, bag
Dress, finished product is described to be packaged as plastics package, every bag of 1.6g, totally 200000 bags.
Comparative example 1
A kind of drink, its preparation process is as follows：960g Qingqian Willow leafs are taken, 20g Jasmines are ground into 12 mesh particles, every bag
5g。
Comparative example 2
A kind of drink, its preparation process is as follows：960g balsam pears jerky, 20g Jasmines are taken, 12 mesh particles, every bag are ground into
5g。
Comparative example 3
A kind of drink, its preparation process is as follows
(1) balsampear leaf 18.63g, balsampear stem 18.63g, balsam pear jerky 24.84g are weighed, is well mixed, extraction process is strictly according to the facts
Example 1 is applied, Bitter Melon P.E medicinal extract 18.75g (being completely dried rear quality for 10.5g) is obtained.
(2) Qingqian Willow leaf 300g, balsam pear jerky 89.5g, mulberry leaf 20g, selfheal 20g, chrysanthemum indicum 15g, Jasmine are weighed
5g, is well mixed, is ground into 32 mesh particles, is well mixed with Bitter Melon P.E medicinal extract 18.75g, pelletizes, and gained particle crosses 12 mesh
Sieve, is dried, and sterilizing is fitted into non-woven fabrics inner packing, every bag of 5g, outer packing is plastics package, finished product.
Comparative example 4
A kind of drink, its preparation process is as follows
(1) balsampear leaf 56.1g, balsampear stem 5601g, balsam pear jerky 74.8g are weighed, is well mixed, extraction process is as implemented
Example 1, obtains Bitter Melon P.E medicinal extract 56.4g (being completely dried rear quality for 31.6g).
(2) balsam pear jerky 268.4g, mulberry leaf 200g, selfheal 200g, chrysanthemum indicum 200g, Jasmine 100g are weighed, is mixed
Uniformly, 32 mesh particles are ground into, are well mixed with Bitter Melon P.E medicinal extract 56.4g, are pelletized, gained particle crosses 12 mesh sieves, are dried,
Sterilizing, is fitted into non-woven fabrics inner packing, every bag of 5g, outer packing is plastics package, finished product.
Comparative example 5
A kind of drink, its preparation process is as follows
Qingqian Willow leaf 400g, mulberry leaf 200g, selfheal 200g, chrysanthemum indicum 150g, Jasmine 50g are weighed, is well mixed, powder
32 mesh particles are broken into, methylcellulose 330g is added, granulation, gained particle crosses 12 mesh sieves, dries, sterilizing loads in non-woven fabrics
In packaging, every bag of 6.5g, outer packing is plastics package, finished product.
Comparative example 6
A kind of drink, its preparation process is as follows：
Mulberry leaf 350g, selfheal 350g, chrysanthemum indicum 200g, Jasmine 100g are weighed, is well mixed, is ground into 32 mesh
Grain, adds methylcellulose 330g, and granulation, gained particle crosses 12 mesh sieves, dries, and sterilizing is fitted into non-woven fabrics inner packing, every bag
6.5g, outer packing is plastics package, finished product.
Comparative example 7
A kind of drink, its preparation process is as follows：
Balsampear leaf 18.63g, balsampear stem 18.63g, balsam pear jerky 24.84g are weighed, is well mixed, extraction process is as implemented
Example 1, obtains Bitter Melon P.E medicinal extract 18.75g (being completely dried rear quality for 10.5g).
Qingqian Willow leaf 400g, balsam pear jerky 89.5g, selfheal 20g, chrysanthemum indicum 20g, Jasmine 10g are weighed, mixing is equal
It is even, 32 mesh particles are ground into, are well mixed with Bitter Melon P.E medicinal extract 18.75g, are pelletized, gained particle crosses 12 mesh sieves, are dried,
Sterilizing, is fitted into non-woven fabrics inner packing, every bag of 5g, outer packing is plastics package, finished product.
Comparative example 8
A kind of drink, its preparation process is as follows：
Balsampear leaf 18.63g, balsampear stem 18.63g, balsam pear jerky 24.84g are weighed, is well mixed, extraction process is as implemented
Example 1, obtains Bitter Melon P.E medicinal extract 18.75g (being completely dried rear quality for 10.5g).
Qingqian Willow leaf 400g, balsam pear jerky 89.5g, mulberry leaf 20g, chrysanthemum indicum 20g, Jasmine 10g are weighed, is well mixed,
32 mesh particles are ground into, are well mixed with Bitter Melon P.E medicinal extract 18.75g, are pelletized, gained particle crosses 12 mesh sieves, dries, goes out
Bacterium, is fitted into non-woven fabrics inner packing, every bag of 5g, and outer packing is plastics package, finished product.
Comparative example 9
A kind of drink, its preparation process is as follows：
Balsampear leaf 18.63g, balsampear stem 18.63g, balsam pear jerky 24.84g are weighed, is well mixed, extraction process is as implemented
Example 1, obtains Bitter Melon P.E medicinal extract 18.75g (being completely dried rear quality for 10.5g).
Qingqian Willow leaf 400g, balsam pear jerky 89.5g, selfheal 20g, selfheal 20g, Jasmine 10g are weighed, mixing is equal
It is even, 32 mesh particles are ground into, are well mixed with Bitter Melon P.E medicinal extract 18.75g, are pelletized, gained particle crosses 12 mesh sieves, are dried,
Sterilizing, is fitted into non-woven fabrics inner packing, every bag of 5g, outer packing is plastics package, finished product.
Experimental example 1
First, screening object and packet
According to the World Health Organization (WHO) diagnostic criteria in 1999,75g anhydrous grapes carbohydrate tolerance test by oral administration was screened
Research object, excludes angiocarpy, liver, kidney diaseases and infectious diseases and Diabetic Acute complication, screens 24 II type glycosurias
Patient is research object, wherein man 13, female 11, age 40-75 Sui, average age is 61.3 ± 1.4 years old, course of disease 2-8
Contrasted in terms of year, average course of disease 3.7 ± 1.2 years, 24 Genders, age and the courses of disease, no significant difference (P ＞ 0.05),
It is not statistically significant, with comparativity.This 24 patients are randomly divided into 12 groups, respectively every group of 2 people, control group, blue or green money willow
Bitter gourd sugar-reducing tea bag make tea group (embodiment 1), blue or green money willow bitter gourd sugar-reducing tea granule agent group (embodiment 2), 1 group of comparative example, contrast
2 groups of example, 3 groups of comparative example, 4 groups of comparative example, 5 groups of comparative example, 6 groups of comparative example, 7 groups of comparative example, 8 groups of comparative example, 9 groups of comparative example.
2nd, treatment method
Control group treatment method is：Oral glimepiride, daily dosage is 2mg, once a day.
Blue or green money willow bitter gourd sugar-reducing tea bag group (embodiment 1) treatment method of making tea is：Oral Glimepiride, daily dosage is
1mg, once a day, daily 3 bags of 1 gained blue or green money willow balsom pear tea bag of embodiment, brewed for drinking.
Blue or green money willow bitter gourd sugar-reducing tea granule agent group (embodiment 2) treatment method is：Oral Glimepiride, daily dosage is
1mg, once a day, daily 3 bags of the gained granule of embodiment 2, warm water, which is brewed, to be drunk.
1 group for the treatment of method of comparative example is：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 1
Make tea daily 3 bags, brewed for drinking.
2 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 2
Make tea daily 3 bags, brewed for drinking.
3 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 3
Make tea daily 3 bags, brewed for drinking.
4 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 4
Make tea daily 3 bags, brewed for drinking.
5 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 5
Make tea daily 3 bags, brewed for drinking.
6 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 6
Make tea daily 3 bags, brewed for drinking.
7 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 7
Make tea daily 3 bags, brewed for drinking.
8 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 8
Make tea daily 3 bags, brewed for drinking.
9 groups for the treatment of methods of comparative example are：Oral Glimepiride, daily dosage is 1mg, once a day, the gained bag of comparative example 9
Make tea daily 3 bags, brewed for drinking.
Fasting blood-glucose (FPG), after the meal 2 hours blood glucoses (2hPG) after above each group is treated 1 day are determined respectively, the results are shown in Table 1.
The experimental data of the experimental example 1 of table 1
As seen from the results in Table 1, blue or green money willow bitter gourd sugar-reducing tea bag make tea group and blue or green money willow bitter gourd sugar-reducing tea granule agent group drop
Sugared effect is suitable with individually using the hypoglycemic effect of Glimepiride, and the consumption of Glimepiride can be reduced to two points of former dosage
One of.From the hypoglycemic result of comparative example 1-9 groups, the raw material proportioning of blue or green money willow balsom pear tea bag and its granule is aided in it
Hypoglycemic effect has considerable influence.
Experimental example 2
First, screening object and packet
According to the World Health Organization (WHO) diagnostic criteria in 1999,75g anhydrous grapes carbohydrate tolerance test by oral administration was screened
Research object, excludes angiocarpy, liver, kidney diaseases and infectious diseases and Diabetic Acute complication, screens 24 II type glycosurias
Patient is research object, wherein man 12, female 12, age 35-75 Sui, average age is 54.1 ± 1.7 years old, course of disease 2-8
Contrasted in terms of year, average course of disease 2.7 ± 1.6 years, 24 Genders, age and the courses of disease, no significant difference (P ＞ 0.05),
It is not statistically significant, with comparativity.This 24 patients are randomly divided into 12 groups, respectively every group of 2 people, control group, blue or green money willow
Bitter gourd sugar-reducing tea bag make tea group (embodiment 1), blue or green money willow bitter gourd sugar-reducing tea granule agent group (embodiment 2), 1 group of comparative example, contrast
2 groups of example, 3 groups of comparative example, 4 groups of comparative example, 5 groups of comparative example, 6 groups of comparative example, 7 groups of comparative example, 8 groups of comparative example, 9 groups of comparative example.
2nd, treatment method
Control group treatment method is：Oral melbine hydrocloride is treated, and daily dosage is 1.5g, three times a day.
A blue or green money willow bitter gourd sugar-reducing tea bag group treatment method of making tea is：Oral melbine hydrocloride is treated, and daily dosage is
0.75g, twice a day, daily 3 bags of 1 gained blue or green money willow balsom pear tea bag of embodiment, brewed for drinking.
Blue or green money willow bitter gourd sugar-reducing tea granule agent group treatment method is：Oral melbine hydrocloride is treated, and daily dosage is
0.75g, twice a day, daily 3 bags of the gained granule of embodiment 2, warm water, which is brewed, to be drunk.
1 group for the treatment of method of comparative example is：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 1, brewed for drinking.
2 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 2, brewed for drinking.
3 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 3, brewed for drinking.
4 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 4, brewed for drinking.
5 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 5, brewed for drinking.
6 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 6, brewed for drinking.
7 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 7, brewed for drinking.
8 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 8, brewed for drinking.
9 groups for the treatment of methods of comparative example are：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, right
Daily 3 bags of the gained tea bag of ratio 9, brewed for drinking.
Fasting blood-glucose (FPG), after the meal 2 hours blood glucoses (2hPG) after above each group is treated 1 day are determined respectively, the results are shown in Table 2.
The experimental data of the experimental example 2 of table 2
As seen from the results in Table 2, blue or green money willow bitter gourd sugar-reducing tea bag make tea group and blue or green money willow bitter gourd sugar-reducing tea granule agent group drop
Sugared effect is suitable with individually using the hypoglycemic effect of Metformin hydrochloride, and the consumption of Metformin hydrochloride can be reduced into former agent
/ 2nd of amount.From the hypoglycemic result of comparative example 1-9 groups, the raw material proportioning of blue or green money willow balsom pear tea bag and its granule
There is considerable influence to the effect of its auxiliary hyperglycemic.
Experimental example 3
First, screening object and packet
According to the World Health Organization (WHO) diagnostic criteria in 1999,75g anhydrous grapes carbohydrate tolerance test by oral administration was screened
Research object, excludes angiocarpy, liver, kidney diaseases and infectious diseases and Diabetic Acute complication, screens 24 II type glycosurias
Patient is research object, wherein man 9, female 15, age 40-75 Sui, average age is 58.3 ± 2.2 years old, course of disease 2-8
Contrasted in terms of year, average course of disease 2.3 ± 1.6 years, 24 Genders, age and the courses of disease, no significant difference (P ＞ 0.05),
It is not statistically significant, with comparativity.This 24 patients are randomly divided into 12 groups, respectively every group of 2 people, control group, blue or green money willow
Bitter gourd sugar-reducing tea bag make tea group (embodiment 1), blue or green money willow bitter gourd sugar-reducing tea granule agent group (embodiment 2), 1 group of comparative example, contrast
2 groups of example, 3 groups of comparative example, 4 groups of comparative example, 5 groups of comparative example, 6 groups of comparative example, 7 groups of comparative example, 8 groups of comparative example, 9 groups of comparative example.
2nd, treatment method
Control group treatment method is：Oral acarbose treating, daily dosage is 150mg, three times a day.
A blue or green money willow bitter gourd sugar-reducing tea bag group treatment method of making tea is：Oral acarbose treating, daily dosage is 100mg,
Twice a day, daily 3 bags of 1 gained blue or green money willow balsom pear tea bag of embodiment, brewed for drinking.
Blue or green money willow bitter gourd sugar-reducing tea granule agent group treatment method is：Oral acarbose treating, daily dosage is 100mg,
Twice a day, daily 3 bags of the gained granule of embodiment 2, warm water, which is brewed, to be drunk.
1 group for the treatment of method of comparative example is：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 1
Daily 3 bags of gained tea bag, brewed for drinking.
2 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 2
Daily 3 bags of gained tea bag, brewed for drinking.
3 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 3
Daily 3 bags of gained tea bag, brewed for drinking.
4 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 4
Daily 3 bags of gained tea bag, brewed for drinking.
5 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 5
Daily 3 bags of gained tea bag, brewed for drinking.
6 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 6
Daily 3 bags of gained tea bag, brewed for drinking.
7 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 7
Daily 3 bags of gained tea bag, brewed for drinking.
8 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 8
Daily 3 bags of gained tea bag, brewed for drinking.
9 groups for the treatment of methods of comparative example are：Oral acarbose treating, daily dosage is 100mg, twice a day, comparative example 9
Daily 3 bags of gained tea bag, brewed for drinking.
Fasting blood-glucose (FPG), after the meal 2 hours blood glucoses (2hPG) after above each group is treated 1 day are determined respectively, the results are shown in Table 3.
The experimental data of the experimental example 3 of table 3
As seen from the results in Table 3, the hypoglycemic effect of blue or green money willow balsom pear tea bag group and granule group is with individually using acarbose
The consumption of acarbose quite, and can be reduced to 2/3rds of former dosage by hypoglycemic effect.By the drop of comparative example 1-9 groups
Sugared result understands that the raw material proportioning of blue or green money willow balsom pear tea bag and its granule has larger shadow to the effect of its auxiliary hyperglycemic
Ring.
Experimental example 4
First, screening object and packet
According to the World Health Organization (WHO) diagnostic criteria in 1999,75g anhydrous grapes carbohydrate tolerance test by oral administration was screened
Research object, excludes angiocarpy, liver, kidney diaseases and infectious diseases and Diabetic Acute complication, screens 18 II type glycosurias
Patient is research object, wherein man 10, female 8, age 40-75 Sui, average age is 51.9 ± 3.6 years old, course of disease 2-8
Contrasted in terms of year, average course of disease 2.7 ± 1.2 years, 18 Genders, age and the courses of disease, no significant difference (P ＞ 0.05),
It is not statistically significant, with comparativity.This 18 patients are randomly divided into 9 groups, respectively every group of 2 people, 1-9 groups.
2nd, treatment method
All patient blood glucoses are determined before treatment, before treatment starts, in addition to the medicine of experiment, all patients disable any with controlling
Treat the relevant medicine of diabetes.
1 group for the treatment of method：Oral glimepiride, daily dosage is 2mg, once a day, is treated 12 weeks；
2 groups for the treatment of methods：Oral Glimepiride, daily dosage is 1mg, once a day, the gained blue or green money willow balsam pear of embodiment 1
Daily 3 bags of tea bag, brewed for drinking is treated 12 weeks；
3 groups for the treatment of methods：Oral Glimepiride, daily dosage is 1mg, once a day, and the gained granule of embodiment 2 is daily
3 bags, warm water, which is brewed, to be drunk, and is treated 12 weeks；
4 groups for the treatment of methods：Oral melbine hydrocloride is treated, and daily dosage is 1.5g, three times a day, is treated 12 weeks；
5 groups for the treatment of methods：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, the gained of embodiment 1
Blue or green money willow bitter gourd sugar-reducing tea bag is made tea daily 3 bags, brewed for drinking, is treated 12 weeks；
6 groups for the treatment of methods：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, the gained of embodiment 2
Daily 3 bags of blue or green money willow bitter gourd sugar-reducing tea granule agent, warm water, which is brewed, to be drunk, and is treated 12 weeks；
7 groups for the treatment of methods：Oral acarbose treating, daily dosage is 150mg, three times a day, is treated 12 weeks；
8 groups for the treatment of methods：Oral acarbose treating, daily dosage is 100mg, twice a day, the blue or green money of the gained of embodiment 1
Willow bitter gourd sugar-reducing tea bag is made tea daily 3 bags, brewed for drinking, is treated 12 weeks；
9 groups for the treatment of methods：Granule group treatment method is：Oral acarbose treating, daily dosage is 100mg, one day
Twice, daily 3 bags of the gained blue or green money willow bitter gourd sugar-reducing tea granule agent of embodiment 2, warm water, which is brewed, to be drunk, and is treated 12 weeks.
Detect respectively above-mentioned 1-9 groups patient treat 12 weeks before and after fasting blood-glucose (FPG), after the meal 2 hours blood glucoses (2hPG),
Glycosylated hemoglobin (HbA1c), and statistics have the number of adverse reaction, the results are shown in Table 4.
Adverse reaction includes：Gastrointestinal reaction, central nervous system symptom, granulocyte, decrease of platelet, cholestatic are yellow
Subcutaneous ulcer and hepatic lesion, continuation hypoglycemia；Loss of appetite, diarrhoea, stomachache, headache, dizziness, megaloblastic anemia, lactate
Acidaemia, ketonemia；The high inlet and outlet of abdominal distension, stomachache, gurgling sound increase in one or more.
The experimental data of the experimental example 4 of table 4
1st, the standard of curative effect evaluation：
It is effective：Patient's fasting blood-glucose≤6.39mmol/L, 2h-plasma glucose≤7.8mmol/L；
Effectively:Patient's fasting blood-glucose≤7.8mmol/L, 2h-plasma glucose≤11.1mmol/L；
It is invalid：It's too late that symptom is without any improvement by patient blood glucose.
2nd, the relation of the control situation of glycosylated hemoglobin and blood glucose：
When glycosylated hemoglobin is 4%-6%, glycemic control is normal；
When glycosylated hemoglobin is 6%-7%, glycemic control is more satisfactory；
When glycosylated hemoglobin is 7%-8%, glycemic control is general；
When glycosylated hemoglobin is 8%-9%, glycemic control is undesirable, need to strengthen glycemic control, and be careful in one's diet knot more
Structure and motion, and adjust control program under the guidance of doctor；
When glycosylated hemoglobin is more than 9%, glycemic control is very poor, is the hazards that chronic complicating diseases develop,
The complication such as nephrosis, artery sclerosis, cataract may be triggered, and be possible to the acute merging such as DKA occur
Disease.
As seen from the results in Table 4, above-mentioned each group patient was by the treatment of 12 weeks, and glycemic control effect is more satisfactory.Sent out with this
The bright blue or green money willow bitter gourd sugar-reducing tea bag make tea or blue or green money willow bitter gourd sugar-reducing tea granule agent auxiliary treatment type II diabetes effect
More alone Glimepiride, Metformin hydrochloride, acarbose effect more preferably, and the consumption per day of medicine can be reduced to former agent
2nd/to three/2nds of amount, make tea because of blue or green money willow bitter gourd sugar-reducing tea bag and are used with blue or green money willow bitter gourd sugar-reducing tea granule agent
Raw material be integration of drinking and medicinal herbs raw material, safety non-toxic by the treatment of 12 weeks, has no adverse reaction, effectively reduces long-term taking
The side effect brought of medicine.
Model case 1
Patient Zhang, female, 58 years old, height 159cm, body weight 64Kg, BMI25.3Kg/m2It is diagnosed as type II diabetes 2 years
Remaining, cardinal symptom is thirsty, many drinks, weak.Inspection result：Fasting blood-glucose：9.5mmol/L, 2 hours 13.1mmol/L, sugared after the meal
Change hemoglobin 7.1%, liver function, kidney work(, blood pressure, blood fat,Hepatitis BFive, urinate it is micro-AmountFour, albumen, rabat, electrocardiogram, liver and gall
The double kidney B ultrasound no abnormality seens of spleen.
Therapeutic scheme：Oral Glimepiride, daily dosage is 1mg, once a day, and the oral gained blue or green money willow of embodiment 1 is bitter
Daily 3 bags of melon blood-sugar reducing tea tea bag, brewed for drinking.
Inspection result after treating 2 months：Fasting blood-glucose：5.7mmol/L, after the meal 2 hours 8.7mmol/L, HbAle egg
White 6.1%.
Model case 2
Patient Lee, man, 62 years old, height 172cm, body weight 76Kg, BMI25.6Kg/m2, it is diagnosed as type II diabetes 3 years
It is remaining, many drinks, diuresis, intermittent weak, body weight increase and decrease is not obvious.Inspection result：Fasting blood-glucose：9.6mmol/L, after the meal 2 hours
14.3mmol/L, glycosylated hemoglobin 7.2%, liver function, kidney work(, blood pressure, blood fat, five indexes of hepatitis b, urine micro protein four, chest
The double kidney B ultrasound no abnormality seens of piece, electrocardiogram, liver and gall spleen.
Therapeutic scheme：Oral melbine hydrocloride is treated, and daily dosage is 0.75g, twice a day, and the gained of embodiment 2 is blue or green
Daily 3 bags of money willow bitter gourd sugar-reducing tea granule agent, warm water, which is brewed, to be drunk.
Inspection result after treating 2 months：Fasting blood-glucose：6.2mmol/L, after the meal 2 hours 9.1mmol/L, HbAle egg
White 6.3%.
Model case 3
The patient Qin, female, 48 years old, height 161cm, body weight 68Kg, BMI26.2Kg/m2, it is diagnosed as type II diabetes 2.5
Year, many drinks, diuresis are intermittent weak.Inspection result：Fasting blood-glucose：9.6mmol/L, 2 hours 14.3mmol/L, are saccharified after the meal
Hemoglobin 7.2%, liver function, kidney work(, blood pressure, blood fat, five indexes of hepatitis b, urine micro protein four, rabat, electrocardiogram, liver and gall spleen
Double kidney B ultrasound no abnormality seens.
Therapeutic scheme：Oral acarbose treating, daily dosage is 100mg, twice a day, the gained blue or green money willow of embodiment 1
Bitter gourd sugar-reducing tea bag is made tea daily 3 bags, brewed for drinking.
Inspection result after treating 2 months：Fasting blood-glucose：5.9mmol/L, after the meal 2 hours 9.0mmol/L, HbAle egg
White 6.4%.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of blue or green money willow bitter gourd sugar-reducing tea, it is characterised in that be made by the raw material including following parts by weight：Qingqian Willow leaf 1-20
Part, 40-80 parts of balsam pear class, 1-15 parts of mulberry leaf, 1-15 parts of selfheal, 1-10 parts of chrysanthemum indicum, 1-5 parts of jasmine tea；Wherein, the balsam pear
Class is the combination of Bitter Melon P.E, balsam pear jerky or balsam pear jerky and Bitter Melon P.E.
2. blue or green money willow bitter gourd sugar-reducing tea according to claim 1, it is characterised in that the Bitter Melon P.E is from balsam pear
Extract what is obtained in leaf, balsampear stem and balsam pear jerky；Wherein, the balsampear leaf：Balsampear stem：The mass ratio of balsam pear jerky is (1-
6):(1-4):(2-10)；
Preferably, when the blue or green money willow bitter gourd sugar-reducing tea is tea bag, the balsampear leaf：Balsampear stem：The quality of balsam pear jerky
Than for 3:3:4；When the blue or green money willow bitter gourd sugar-reducing tea is granule, the balsampear leaf：Balsampear stem：The mass ratio of balsam pear jerky
For 1:1:6.
3. blue or green money willow bitter gourd sugar-reducing tea according to claim 1 or 2, it is characterised in that the Bitter Melon P.E is by as follows
Method is made：The balsampear leaf for the ratio for preparing, balsampear stem and balsam pear jerky are ground into 10-30 mesh particles, 1-20 times of 50%- is added
90% ethanol, adjustment pH value to 6.0-8.0 is extracted 6-10 hours in 20 DEG C -50 DEG C, is extracted 2 times, and filtering takes filtrate；Add
1-10 times of 50%-90% ethanol, adjustment pH value to 6.0-8.0 is extracted 6-10 hours in 20 DEG C -50 DEG C, and filtering takes filtrate；Close
And three filtrates, relative density is concentrated in vacuo to for 1.05-1.2, Bitter Melon P.E medicinal extract is obtained, and is dried, is produced Bitter Melon P.E.
4. according to any described blue or green money willow bitter gourd sugar-reducing tea of claim 1-3, it is characterised in that the jasmine tea is derived from Jasmine
One or more in tea, osmanthus flower tea, chrysanthemum tea or rose tea；Chrysanthemum selection tire chrysanthemum in wherein described chrysanthemum tea, tribute chrysanthemum
Or the one or more in FLOS CHRYSANTHEMI ALBA from Haizhou of China.
5. blue or green money willow bitter gourd sugar-reducing tea according to claim 1, it is characterised in that by the raw material system for including following parts by weight
：5-20 parts of Qingqian Willow leaf, 45-80 parts of balsam pear class, 5-12 parts of mulberry leaf, 5-12 parts of selfheal, 1-10 parts of chrysanthemum indicum, jasmine tea 1-5
Part.
6. blue or green money willow bitter gourd sugar-reducing tea according to claim 1, it is characterised in that by the raw material system for including following parts by weight
：6-12 parts of Qingqian Willow leaf, 70-80 parts of balsam pear class, 4-8 parts of mulberry leaf, 4-8 parts of selfheal, 3-5 parts of chrysanthemum indicum, 1-3 parts of jasmine tea；
Still more preferably, the blue or green money willow bitter gourd sugar-reducing tea is made by the raw material including following parts by weight：8 parts of Qingqian Willow leaf, balsam pear
76 parts of class, 5 parts of mulberry leaf, 5 parts of selfheal, 4 parts of chrysanthemum indicum, 2 parts of jasmine tea；
Or, it is made by the raw material including following parts by weight：15-20 parts of Qingqian Willow leaf, 40-50 parts of balsam pear class, 8-15 parts of mulberry leaf,
8-15 parts of selfheal, 8-10 parts of chrysanthemum indicum, jasmine tea 3-5 material are made：Still more preferably, the blue or green money willow bitter gourd sugar-reducing tea is by wrapping
The raw material for including following parts by weight is made：18 parts of Qingqian Willow leaf, 45 parts of balsam pear class, 11 parts of mulberry leaf, 11 parts of selfheal, chrysanthemum indicum 10
Part, 5 parts of jasmine tea.
7. according to any blue or green money willow bitter gourd sugar-reducing tea of claim 1-6, it is characterised in that the blue or green money willow bitter gourd sugar-reducing tea
Granule or tea bag is made according to demand.
8. blue or green money willow bitter gourd sugar-reducing tea according to claim 7, it is characterised in that the granule is comprised the following steps：
Qingqian Willow leaf, mulberry leaf, selfheal, chrysanthemum indicum, jasmine tea are weighed in proportion, extracts or is extracted after mixing respectively, gained is always extracted
Thing again with balsam pear class, food additives mixing granulation, sieve, dry, sterilize, packaging, finished product.
9. blue or green money willow bitter gourd sugar-reducing tea according to claim 7, it is characterised in that the tea bag is comprised the following steps：
By Qingqian Willow leaf, balsam pear class, mulberry leaf, selfheal, chrysanthemum indicum, jasmine tea mixing granulation in proportion, wherein balsam pear class is carried selected from balsam pear
Thing and balsam pear jerky are taken, the two weight ratio is 1：8-9, gained pellet through sieves are dried, and are sterilized, packaging, finished product.
10. application of any blue or green money willow bitter gourd sugar-reducing tea of claim 1-9 in health food.
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| CN108935842A (en) * | 2018-06-28 | 2018-12-07 | 华南农业大学 | A kind of preparation and application of balsam pear blue or green money willow lipid-lowering health-care tea |
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| CN107136269B (en) | 2020-09-15 |
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