CN107136269B - Cyclocarya paliurus and bitter gourd blood sugar reducing tea and preparation method thereof - Google Patents
Cyclocarya paliurus and bitter gourd blood sugar reducing tea and preparation method thereof Download PDFInfo
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Abstract
The invention relates to cyclocarya paliurus-bitter gourd blood sugar reducing tea and a preparation method thereof. The cyclocarya paliurus-bitter gourd blood glucose reducing tea is prepared from the following raw materials in parts by weight: 1-20 parts of cyclocarya paliurus leaves, 40-80 parts of bitter melons, 1-15 parts of mulberry leaves, 1-15 parts of selfheal, 1-10 parts of wild chrysanthemum flowers and 1-5 parts of scented tea; wherein the bitter gourds are bitter gourd extracts, bitter gourd jerky or a combination of bitter gourd jerky and bitter gourd extracts. The raw materials used in the invention are homologous in medicine and food, and have no toxic or side effect; the traditional Chinese medicine composition has a good auxiliary treatment effect on type II diabetes, can reduce the daily dosage of the medicine to one half to two thirds of the original dosage, has no adverse reaction, and effectively reduces the side effect of the medicine.
Description
Technical Field
The invention relates to cyclocarya paliurus-bitter gourd blood sugar reducing tea and a preparation method thereof, and belongs to medical health care tea.
Background
Diabetes (diabetes) is a series of metabolic disorder syndromes of sugar, protein, fat, water, electrolyte and the like caused by hypofunction of pancreatic islets, insulin resistance and the like due to the action of various pathogenic factors such as genetic factors, immune dysfunction, microbial infection and toxins thereof, free radical toxins, mental factors and the like on the body.
Currently, there are insulin and oral hypoglycemic agents, including sulfonylureas, biguanides, benzoic acid derivatives, alpha-glucosidase inhibitors, thiazolidinediones, which treat diabetes. However, the current therapeutic drugs have some serious side effects.
Disclosure of Invention
The cyclocarya paliurus and bitter gourd blood sugar reducing tea and the preparation method thereof provided by the invention can be used together with insulin or various oral blood sugar reducing medicines to assist in reducing blood sugar, particularly have a good effect of assisting in reducing blood sugar in the early stage of type II diabetes, and reduce the dosage of the insulin or various oral blood sugar reducing medicines, so that the side effect brought by the medicines is reduced. The preparation method of the composition with the effect of reducing blood sugar has the characteristics of simple process, low cost and contribution to industrial production.
In order to achieve the purpose, the invention adopts the following technical scheme:
a cyclocarya paliurus-bitter gourd blood sugar reducing tea is prepared from the following raw materials in parts by weight: 1-20 parts of cyclocarya paliurus leaves, 40-80 parts of bitter melons, 1-15 parts of mulberry leaves, 1-15 parts of selfheal, 1-10 parts of wild chrysanthemum flowers and 1-5 parts of scented tea;
wherein the bitter gourds are bitter gourd extracts, bitter gourd jerky or a combination of the bitter gourd jerky and the bitter gourd extracts; preferably, in the combination of the dried balsam pear flesh and the extract of balsam pear, the weight ratio of the extract of balsam pear to the dried balsam pear flesh is 1: 7-9; preferably 1: 8.5.
the balsam pear extract is extracted from balsam pear leaves, balsam pear vines and balsam pear jerky; wherein, the balsam pear leaves: balsam pear vine: the mass ratio of the balsam pear jerky is (1-6) to (1-4) to (2-10); more preferably, when the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is a tea bag, the ratio of the bitter gourd leaves: balsam pear vine: the mass ratio of the balsam pear jerky is 3:3: 4; when the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is granules, the bitter gourd leaves are: balsam pear vine: the mass ratio of the balsam pear jerky is 1:1: 6.
The bitter gourd extract is prepared by the following method: pulverizing folium Momordicae Charantiae, caulis Momordicae Charantiae and fructus Momordicae Charantiae into 10-30 mesh particles, adding 1-20 times of 50% -90% ethanol, adjusting pH to 6.0-8.0, extracting at 20-50 deg.C for 6-10 hr for 2 times, filtering, and collecting filtrate; adding 1-10 times of 50% -90% ethanol, adjusting pH to 6.0-8.0, extracting at 20-50 deg.C for 6-10 hr, filtering, and collecting filtrate; mixing the three filtrates, vacuum concentrating to relative density of 1.05-1.2 (preferably relative density of 1.15), to obtain extract, and drying to obtain fructus Momordicae Charantiae extract.
The scented tea is one or more selected from jasmine tea, sweet osmanthus tea, chrysanthemum tea or rose tea; wherein the chrysanthemum in the chrysanthemum tea is one of chrysanthemum bud, chrysanthemum tribute or chrysanthemum morifolium.
As one of the preferable embodiments of the invention, the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is prepared from the following raw materials in parts by weight: 5-20 parts of cyclocarya paliurus leaves, 45-80 parts of bitter gourds, 5-12 parts of mulberry leaves, 5-12 parts of selfheal, 1-10 parts of wild chrysanthemum flowers and 1-5 parts of scented tea.
As one of the preferable embodiments of the invention, the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is prepared from the following raw materials in parts by weight: 6-12 parts of cyclocarya paliurus leaves, 70-80 parts of bitter melons, 4-8 parts of mulberry leaves, 4-8 parts of selfheal, 3-5 parts of wild chrysanthemum flowers and 1-3 parts of scented tea; more preferably, the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is prepared from the following raw materials in parts by weight: 8 parts of cyclocarya paliurus leaves, 76 parts of bitter melons, 5 parts of mulberry leaves, 5 parts of selfheal, 4 parts of wild chrysanthemum flowers and 2 parts of scented tea.
As one of the preferable embodiments of the invention, the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is prepared from the following raw materials in parts by weight: 15-20 parts of cyclocarya paliurus leaves, 40-50 parts of bitter gourds, 8-15 parts of mulberry leaves, 8-15 parts of selfheal, 8-10 parts of wild chrysanthemum flowers and 3-5 parts of scented tea, and the traditional Chinese medicine is prepared from the following raw materials: more preferably, the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is prepared from the following raw materials in parts by weight: 18 parts of cyclocarya paliurus leaves, 45 parts of bitter gourds, 11 parts of mulberry leaves, 11 parts of selfheal, 10 parts of wild chrysanthemum flowers and 5 parts of scented tea. The cyclocarya paliurus-bitter gourd blood sugar reducing tea has the effect of reducing blood sugar, is convenient for consumers to use, and is improved aiming at the specification, dosage form, package and the like of the cyclocarya paliurus-bitter gourd blood sugar reducing tea. Preferably, the cyclocarya paliurus-bitter gourd blood sugar reducing tea is prepared into granules or tea bags.
The invention also provides a preparation process of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea, which specifically comprises the following steps: mixing folium cyclocarya paliurus, folium Mori, Prunellae Spica, flos Chrysanthemi Indici, and scented tea at a certain proportion, mixing or adding bitter gourd according to final product dosage form, and preparing according to conventional preparation process of dosage form.
Wherein the granules are prepared by the following method: weighing cyclocarya paliurus leaves, folium mori, selfheal, wild chrysanthemum flower and scented tea in proportion, extracting respectively or extracting after mixing, mixing the obtained total extract with bitter melons and food additives, granulating, sieving, drying, sterilizing and packaging to obtain the finished product.
Wherein the package is a plastic package;
the addition amount of the food additive is 1/4-1/2 of the total extract weight; the food additive is selected from one or more of methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, oxidized starch, oxidized hydroxypropyl starch, gelatin, carrageenan or sodium alginate.
The preferable scheme of the preparation method of the granules is that the granules are prepared by the following steps: pulverizing cyclocarya paliurus leaves, folium mori, selfheal, wild chrysanthemum flower and jasmine flower in a ratio into particles of 10 meshes, adding water, decocting twice, combining decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.2, mixing the extract with the extract of the bitter gourd and methylcellulose, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing and packaging to obtain a finished product, wherein the packaging is plastic packaging; the amount of methylcellulose used is 1/3 based on the total weight of the raw material extract.
The tea bag is prepared by the following method: mixing cyclocarya paliurus leaves, bitter gourds, mulberry leaves, selfheal, wild chrysanthemum flowers and scented tea in proportion and granulating, wherein the bitter gourds are selected from bitter gourd extracts and bitter gourd jerky, and the weight ratio of the bitter gourd extracts to the bitter gourd jerky is 1: 8-9, sieving the obtained granules, drying, sterilizing and packaging to obtain a finished product; wherein the packing divide into inner packing and extranal packing, the inner packing adopts the non-woven fabrics, extranal packing adopts plastic packaging.
The invention has the following beneficial effects:
the tea disclosed by the invention adopts cyclocarya paliurus leaves, bitter melons, mulberry leaves, selfheal and wild chrysanthemum flowers as main raw materials, and is supplemented with scented tea to adjust the taste, the used raw materials are homologous in medicine and food, and the toxic and side effects are small and can be ignored; the traditional Chinese medicine composition has a good effect of assisting in reducing blood sugar for the type II diabetes, particularly for the early stage of the type II diabetes, can reduce the daily dosage of the medicine to be one half to two thirds of the original dosage, has no adverse reaction after 12 weeks of treatment, and effectively reduces the side effect of the medicine.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1 cyclocarya paliurus balsam pear blood sugar reducing tea (teabag)
A cyclocarya paliurus-bitter gourd blood sugar reducing tea is prepared by the following steps:
(1) weighing 142Kg of balsam pear leaves, 142Kg of balsam pear vines and 189Kg of dried balsam pear, uniformly mixing, crushing into 10-mesh particles, adding 5676Kg of 60% ethanol, adjusting the pH value to 6.0, extracting at 50 ℃ for 8 hours, filtering, taking filtrate, and extracting twice in total; adding 3784Kg of 85% ethanol into the residue, adjusting pH to 7.0, extracting at 50 deg.C for 6 hr, filtering, collecting the filtrate, mixing the three filtrates, and vacuum concentrating to relative density of 1.15 (measured at 50 deg.C) to obtain 142.9Kg of fructus Momordicae Charantiae extract (dried weight of 80 Kg);
(2) weighing 80Kg of cyclocarya paliurus leaves, 680Kg of dried balsam pear meat, 50Kg of mulberry leaves, 50Kg of selfheal, 40Kg of wild chrysanthemum flowers and 20Kg of jasmine flowers, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 142.9Kg of balsam pear extract (the mass is 80Kg after drying), granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, and filling into non-woven fabric inner packages, wherein each bag is 5g, and the outer packages are plastic packages, finished products and 200000 bags in total.
Example 2 cyclocarya paliurus balsam pear blood sugar reducing tea (granule)
A cyclocarya paliurus-bitter gourd blood sugar reducing tea is prepared by the following steps:
(1) weighing 145Kg of balsam pear leaves, 145Kg of balsam pear vines and 870Kg of balsam pear jerky, uniformly mixing, crushing into 10-mesh particles, adding 13920Kg of 60% ethanol, adjusting the pH value to 6.0, extracting at 50 ℃ for 8 hours, filtering, taking filtrate, and extracting twice in total; adding 9280Kg of 85% ethanol into the residue, adjusting pH to 7.0, extracting at 50 deg.C for 6 hr, filtering, collecting the filtrate, mixing the three filtrates, and vacuum concentrating to relative density of 1.15 (measured at 50 deg.C) to obtain 350Kg of fructus Momordicae Charantiae extract (dried mass of 196 Kg);
(2) 78Kg of cyclocarya paliurus leaves, 48Kg of mulberry leaves, 48Kg of selfheal, 44Kg of wild chrysanthemum flowers and 22Kg of jasmine flowers are crushed into particles of 10 meshes, the particles are decocted twice by adding water, 2400Kg of water is added each time, the first time is 3 hours, the second time is 2 hours, the decoction liquids are combined and filtered, the filtrate is decompressed and concentrated into 240.4Kg of extract (the mass is 44Kg after drying) with the relative density of 1.2 (measured at 80 ℃), the extract is mixed with 350Kg of extract of balsam pear (the mass is 196Kg after drying) and 80Kg of methyl cellulose for granulation, the obtained particles are sieved by 12 bags, dried, sterilized and packaged into finished products, the package is a plastic package, each bag is 1.6g, and the total bag is 20000.
Comparative example 1
A beverage is prepared by the following steps: 960g of cyclocarya paliurus leaves and 20g of jasmine flowers are taken and crushed into particles of 12 meshes, and each bag is 5 g.
Comparative example 2
A beverage is prepared by the following steps: 960g of dried balsam pear and 20g of jasmine flower are taken and crushed into 12-mesh particles, and each bag contains 5g of the particles.
Comparative example 3
A beverage is prepared by the following steps
(1) Weighing 18.63g of balsam pear leaves, 18.63g of balsam pear stems and 24.84g of dried balsam pear flesh, uniformly mixing, and obtaining 18.75g of balsam pear extract (the mass is 10.5g after complete drying) by the extraction process in the example 1.
(2) Weighing 300g of cyclocarya paliurus leaves, 89.5g of dried balsam pear meat, 20g of mulberry leaves, 20g of selfheal, 15g of wild chrysanthemum flowers and 5g of jasmine flowers, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 18.75g of extract of the balsam pear, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, and filling into non-woven inner packages, wherein each bag is 5g, and the outer packages are plastic packages to obtain finished products.
Comparative example 4
A beverage is prepared by the following steps
(1) 56.1g of balsam pear leaves, 5601g of balsam pear vines and 74.8g of dried balsam pear meat are weighed and mixed uniformly, and the extraction process is as in example 1, so as to obtain 56.4g of balsam pear extract (the mass is 31.6g after complete drying).
(2) Weighing 268.4g of dried balsam pear pulp, 200g of mulberry leaf, 200g of selfheal, 200g of wild chrysanthemum flower and 100g of jasmine flower, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 56.4g of balsam pear extract, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, filling into non-woven inner packages, each bag is 5g, and the outer packages are plastic packages to obtain finished products.
Comparative example 5
A beverage is prepared by the following steps
Weighing 400g of cyclocarya paliurus leaves, 200g of mulberry leaves, 200g of selfheal, 150g of wild chrysanthemum flowers and 50g of jasmine flowers, uniformly mixing, crushing into 32-mesh particles, adding 330g of methylcellulose, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, filling into non-woven inner packages, wherein each bag is 6.5g, and the outer packages are plastic packages to obtain the finished product.
Comparative example 6
A beverage is prepared by the following steps:
weighing 350g of mulberry leaves, 350g of selfheal, 200g of wild chrysanthemum flowers and 100g of jasmine flowers, uniformly mixing, crushing into 32-mesh granules, adding 330g of methyl cellulose, granulating, sieving the obtained granules with a 12-mesh sieve, drying, sterilizing, filling into non-woven inner packages, wherein each bag is 6.5g, and the outer packages are plastic packages to obtain finished products.
Comparative example 7
A beverage is prepared by the following steps:
weighing 18.63g of balsam pear leaves, 18.63g of balsam pear stems and 24.84g of dried balsam pear flesh, uniformly mixing, and obtaining 18.75g of balsam pear extract (the mass is 10.5g after complete drying) by the extraction process in the example 1.
Weighing 400g of cyclocarya paliurus leaves, 89.5g of dried balsam pear meat, 20g of selfheal, 20g of wild chrysanthemum flower and 10g of jasmine flower, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 18.75g of extract of the balsam pear, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, and filling into non-woven inner packages, wherein each bag is 5g, and the outer packages are plastic packages to obtain finished products.
Comparative example 8
A beverage is prepared by the following steps:
weighing 18.63g of balsam pear leaves, 18.63g of balsam pear stems and 24.84g of dried balsam pear flesh, uniformly mixing, and obtaining 18.75g of balsam pear extract (the mass is 10.5g after complete drying) by the extraction process in the example 1.
Weighing 400g of cyclocarya paliurus leaves, 89.5g of dried balsam pear meat, 20g of mulberry leaves, 20g of wild chrysanthemum flowers and 10g of jasmine flowers, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 18.75g of extract of the balsam pear, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, and filling into non-woven inner packages, wherein each bag is 5g, and the outer packages are plastic packages to obtain finished products.
Comparative example 9
A beverage is prepared by the following steps:
weighing 18.63g of balsam pear leaves, 18.63g of balsam pear stems and 24.84g of dried balsam pear flesh, uniformly mixing, and obtaining 18.75g of balsam pear extract (the mass is 10.5g after complete drying) by the extraction process in the example 1.
Weighing 400g of cyclocarya paliurus leaves, 89.5g of dried balsam pear meat, 20g of selfheal and 10g of jasmine flower, uniformly mixing, crushing into 32-mesh particles, uniformly mixing with 18.75g of extract of the balsam pear, granulating, sieving the obtained particles with a 12-mesh sieve, drying, sterilizing, and filling into non-woven inner packages, wherein each bag is 5g, and the outer packages are plastic packages to obtain finished products.
Experimental example 1
Screening objects and grouping
According to the 1999 World Health Organization (WHO) diagnosis standard, a 75g anhydrous glucose tolerance test is adopted to screen a subject, cardiovascular diseases, liver diseases, kidney diseases, infectious diseases and acute complications of diabetes are excluded, 24 type II diabetes patients are screened as the subject, wherein 13 men, 11 women, the age is 40-75 years, the average age is 61.3 +/-1.4 years, the course is 2-8 years, the average course is 3.7 +/-1.2 years, and the sex, the age and the course of 24 patients are compared, have no significant difference (P is more than 0.05), have no statistical significance and have comparability. The 24 patients were randomly divided into 12 groups of 2 patients, each group was a control group, a cyclocarya paliurus bitter gourd blood sugar reducing tea bag group (example 1), a cyclocarya paliurus bitter gourd blood sugar reducing tea granule group (example 2), a comparative example 1 group, a comparative example 2 group, a comparative example 3 group, a comparative example 4 group, a comparative example 5 group, a comparative example 6 group, a comparative example 7 group, a comparative example 8 group and a comparative example 9 group.
Second, therapeutic methods
The control group treatment method comprises the following steps: glimepiride was administered orally at a daily dose of 2mg once a day.
The tea bag group of cyclocarya paliurus and bitter gourd blood sugar reducing tea (example 1) comprises the following treatment methods: the glimepiride is orally taken, the daily dose is 1mg, the cyclocarya paliurus and bitter gourd tea bags obtained in the example 1 are drunk after being bagged in 3 bags every day.
The treatment method of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea granule group (example 2) comprises the following steps: glimepiride was orally administered at a daily dose of 1mg once a day, and the granules obtained in example 2 were taken with 3 bags a day, and were brewed with warm water.
The treatment method of comparative example 1 group was: 1mg of glimepiride is orally taken once a day, and 3 bags of the tea bag obtained in the comparative example 1 are drunk after being made into tea bags.
The treatment methods in comparative example 2 group were: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 2 is drunk after being bagged in 3 bags every day.
The treatment methods in the comparative example 3 group were: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 3 is drunk after being bagged in 3 bags every day.
The treatment method of comparative example 4 group was: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 4 is drunk after being 3 bags every day.
The treatment methods in comparative example 5 group were: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 5 is drunk after being 3 bags per day.
The treatment method of comparative example 6 group was: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 6 is drunk after being 3 bags every day.
The treatment methods in comparative example 7 were: glimepiride was orally administered at a daily dose of 1mg once a day, and the tea bag obtained in comparative example 7 was drunk as tea in 3 bags per day.
The treatment methods of comparative example 8 group were: the glimepiride is orally taken once a day with the daily dose of 1mg, and the tea bag obtained in the comparative example 8 is drunk after being 3 bags every day.
The treatment method of comparative example 9 group was: glimepiride is orally taken once a day at a daily dose of 1mg, and the tea bag obtained in comparative example 9 is drunk after being bagged in 3 bags per day.
Fasting Plasma Glucose (FPG) and 2-hour postprandial plasma glucose (2hPG) were measured after 1 day of treatment in each of the above groups, and the results are shown in Table 1.
TABLE 1 Experimental data for Experimental example 1
The results in table 1 show that the blood sugar reducing effect of the cyclocarya paliurus-bitter gourd blood sugar reducing tea bag group and the cyclocarya paliurus-bitter gourd blood sugar reducing tea granule group is equivalent to the blood sugar reducing effect of glimepiride alone, and the dosage of the glimepiride can be reduced to one half of the original dosage. As shown in the blood sugar reducing results of the comparative examples 1-9, the ingredient ratio of the cyclocarya paliurus-bitter gourd tea bag and the granules thereof has a great influence on the auxiliary blood sugar reducing effect.
Experimental example 2
Screening objects and grouping
According to the 1999 World Health Organization (WHO) diagnosis standard, a 75g anhydrous glucose tolerance test is adopted to screen a subject, cardiovascular diseases, liver diseases, kidney diseases, infectious diseases and acute complications of diabetes are excluded, 24 type II diabetes patients are screened as the subject, wherein 12 men, 12 women, the age is 35-75 years, the average age is 54.1 +/-1.7 years, the course is 2-8 years, the average course is 2.7 +/-1.6 years, and the sex, the age and the course of 24 patients are compared, have no significant difference (P is more than 0.05), have no statistical significance and have comparability. The 24 patients were randomly divided into 12 groups of 2 patients, each group was a control group, a cyclocarya paliurus bitter gourd blood sugar reducing tea bag group (example 1), a cyclocarya paliurus bitter gourd blood sugar reducing tea granule group (example 2), a comparative example 1 group, a comparative example 2 group, a comparative example 3 group, a comparative example 4 group, a comparative example 5 group, a comparative example 6 group, a comparative example 7 group, a comparative example 8 group and a comparative example 9 group.
Second, therapeutic methods
The control group treatment method comprises the following steps: metformin hydrochloride is administered orally in a daily dose of 1.5g three times a day.
The treatment method of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea bag group comprises the following steps: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the cyclocarya paliurus and bitter gourd tea bags obtained in example 1 are taken twice a day, and the cyclocarya paliurus and bitter gourd tea bags are drunk after being made into tea.
The treatment method of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea granule group comprises the following steps: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the granules obtained in example 2 are taken twice a day, and the granules are brewed and drunk by warm water in 3 bags each day.
The treatment method of comparative example 1 group was: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and 3 bags of the tea bags obtained in the comparative example 1 are taken every day and are drunk as tea bags.
The treatment methods in comparative example 2 group were: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and the tea bags obtained in the comparative example 2 are 3 bags per day and are drunk as tea bags.
The treatment methods in the comparative example 3 group were: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and the tea bags obtained in the comparative example 3 are drunk after being taken for 3 bags every day.
The treatment method of comparative example 4 group was: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and 3 bags of tea bags obtained in comparative example 4 are taken every day and are drunk after being made into tea bags.
The treatment methods in comparative example 5 group were: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and the tea bag obtained in the comparative example 5 is 3 bags per day and is drunk as a tea bag.
The treatment method of comparative example 6 group was: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and 3 bags of the tea bags obtained in the comparative example 6 are taken every day and are drunk as tea bags.
The treatment methods in comparative example 7 were: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and 3 bags of the tea bags obtained in the comparative example 7 are taken every day and are drunk as tea bags.
The treatment methods of comparative example 8 group were: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the metformin hydrochloride is taken twice a day, and 3 bags of the tea bags obtained in the comparative example 8 are taken every day and are drunk as tea bags.
The treatment method of comparative example 9 group was: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the dosage is twice a day, and 3 bags of the tea bags obtained in the comparative example 9 are taken every day and are drunk after being made into tea bags.
Fasting Plasma Glucose (FPG) and 2-hour postprandial plasma glucose (2hPG) were measured after 1 day of treatment in each of the above groups, and the results are shown in Table 2.
Table 2 experimental data of experimental example 2
The results in table 2 show that the blood sugar reducing effect of the cyclocarya paliurus-bitter gourd blood sugar reducing tea bag group and the cyclocarya paliurus-bitter gourd blood sugar reducing tea granule group is equivalent to the blood sugar reducing effect of metformin hydrochloride alone, and the dosage of the metformin hydrochloride can be reduced to one half of the original dosage. As shown in the blood sugar reducing results of the comparative examples 1-9, the ingredient ratio of the cyclocarya paliurus-bitter gourd tea bag and the granules thereof has a great influence on the auxiliary blood sugar reducing effect.
Experimental example 3
Screening objects and grouping
According to the 1999 World Health Organization (WHO) diagnosis standard, a 75g anhydrous glucose tolerance test is adopted to screen a subject, cardiovascular diseases, liver diseases, kidney diseases, infectious diseases and acute complications of diabetes are excluded, 24 type II diabetes patients are screened as the subject, wherein 9 men, 15 women, the age is 40-75 years, the average age is 58.3 +/-2.2 years, the course is 2-8 years, the average course is 2.3 +/-1.6 years, and the sex, the age and the course of 24 patients are compared, have no significant difference (P is more than 0.05), have no statistical significance and have comparability. The 24 patients were randomly divided into 12 groups of 2 patients, each group was a control group, a cyclocarya paliurus bitter gourd blood sugar reducing tea bag group (example 1), a cyclocarya paliurus bitter gourd blood sugar reducing tea granule group (example 2), a comparative example 1 group, a comparative example 2 group, a comparative example 3 group, a comparative example 4 group, a comparative example 5 group, a comparative example 6 group, a comparative example 7 group, a comparative example 8 group and a comparative example 9 group.
Second, therapeutic methods
The control group treatment method comprises the following steps: acarbose is administered orally at a daily dose of 150mg three times a day.
The treatment method of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea bag group comprises the following steps: the acarbose is orally taken for treatment, the daily dose is 100mg, the cyclocarya paliurus and bitter gourd tea bags obtained in example 1 are taken twice a day, and the cyclocarya paliurus and bitter gourd tea bags are drunk after being made into tea.
The treatment method of the cyclocarya paliurus-bitter gourd blood sugar-reducing tea granule group comprises the following steps: the acarbose is orally taken for treatment, the daily dose is 100mg, the granules obtained in example 2 are taken twice a day, and the granules are taken after being mixed with warm water in 3 bags each day.
The treatment method of comparative example 1 group was: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 1 is 3 bags per day and is drunk after being made into tea.
The treatment methods in comparative example 2 group were: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 2 is 3 bags per day and is drunk after being made into tea.
The treatment methods in the comparative example 3 group were: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 3 is 3 bags per day and is drunk after being made into tea.
The treatment method of comparative example 4 group was: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in comparative example 4 is 3 bags per day and is drunk after being made into tea.
The treatment methods in comparative example 5 group were: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 5 is 3 bags per day and is drunk after being made into tea.
The treatment method of comparative example 6 group was: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and 3 bags of the tea bags obtained in the comparative example 6 are taken every day and are drunk after being made into tea.
The treatment methods in comparative example 7 were: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 7 is 3 bags per day and is drunk after being made into tea.
The treatment methods of comparative example 8 group were: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 8 is 3 bags per day and is drunk after being made into tea.
The treatment method of comparative example 9 group was: the acarbose is orally taken for treatment, the daily dose is 100mg, the acarbose is taken twice a day, and the tea bag obtained in the comparative example 9 is 3 bags per day and is drunk after being made into tea.
Fasting Plasma Glucose (FPG) and 2-hour postprandial plasma glucose (2hPG) were measured after 1 day of treatment in each of the above groups, and the results are shown in Table 3.
Table 3 experimental data of experimental example 3
As can be seen from the results in Table 3, the blood sugar reducing effect of the cyclocarya paliurus-bitter gourd tea bag group and the particle group is equivalent to the blood sugar reducing effect of the acarbose which is singly used, and the dosage of the acarbose can be reduced to two thirds of the original dosage. As shown in the blood sugar reducing results of the comparative examples 1-9, the ingredient ratio of the cyclocarya paliurus-bitter gourd tea bag and the granules thereof has a great influence on the auxiliary blood sugar reducing effect.
Experimental example 4
Screening objects and grouping
According to the 1999 World Health Organization (WHO) diagnosis standard, subjects are screened by an oral 75g anhydrous glucose tolerance test, cardiovascular, liver and kidney diseases, infectious diseases and acute complications of diabetes are excluded, 18 II type diabetes patients are screened as subjects, wherein 10 men, 8 women, the age is 40-75 years, the average age is 51.9 +/-3.6 years, the course is 2-8 years, the average course is 2.7 +/-1.2 years, and the sex, the age and the course of 18 patients are compared, have no significant difference (P is more than 0.05), have no statistical significance and have comparability. The 18 patients were randomized into 9 groups of 2 patients each, with 1-9 groups.
Second, therapeutic methods
Blood glucose was measured in all patients prior to treatment, and all patients were discontinued from any medication associated with the treatment of diabetes prior to the start of treatment, except the medications tested.
Group 1 treatment methods: oral glimepiride treatment, daily dose of 2mg, once a day for 12 weeks;
group 2 treatment methods: 1mg of glimepiride is orally taken, the daily dose is once a day, and the cyclocarya paliurus and bitter gourd tea bag obtained in the example 1 is drunk after being brewed into tea for 12 weeks;
group 3 treatment methods: taking glimepiride orally, the daily dose is 1mg, taking once a day, the granules obtained in example 2 are taken with 3 bags each day, and the granules are brewed with warm water for drinking for 12 weeks;
group 4 treatment methods: oral metformin hydrochloride treatment, daily dose is 1.5g, three times a day, treatment for 12 weeks;
group 5 treatment methods: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the tea bag is taken twice a day, the cyclocarya paliurus bitter gourd blood sugar reducing tea obtained in the example 1 is 3 bags per day, and the tea bag is drunk for 12 weeks;
group 6 treatment methods: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the cyclocarya paliurus and bitter gourd blood sugar reducing tea granules obtained in the example 2 are taken twice a day, 3 bags are taken every day, and the granules are brewed and drunk by warm water for 12 weeks;
group 7 treatment methods: oral acarbose treatment, daily dose 150mg, three times a day for 12 weeks;
group 8 treatment methods: the acarbose is orally taken for treatment, the daily dose is 100mg, the tea bag is taken twice a day, the cyclocarya paliurus bitter gourd blood sugar reducing tea obtained in the example 1 is taken for 3 bags every day, and the tea bag is drunk for 12 weeks;
group 9 treatment methods: the granule group treatment method comprises the following steps: the acarbose is orally taken for treatment, the daily dose is 100mg, the cyclocarya paliurus-bitter gourd blood sugar reducing tea granules obtained in the example 2 are taken twice a day, 3 bags are taken every day, and the granules are brewed with warm water for drinking for 12 weeks.
The Fasting Plasma Glucose (FPG), postprandial 2-hour plasma glucose (2hPG), and glycated hemoglobin (HbA1c) were measured before and after 12 weeks of treatment in the above-mentioned groups 1 to 9, and the number of patients with adverse reactions was counted, and the results are shown in Table 4.
The adverse reactions include: gastrointestinal reactions, central nervous system symptoms, granulocytes, thrombocytopenia, cholestatic jaundice and liver damage, persistent hypoglycemia; appetite decrease, diarrhea, abdominal pain, headache, dizziness, megaloblastic anemia, lactic acidemia, and ketonemia; one or more of abdominal distention, abdominal pain, hypersusceptibility of bowel sound, and increased exhaust.
Table 4 experimental data of experimental example 4
1. The evaluation standard of the curative effect is as follows:
the effect is shown: the fasting blood sugar of the patient is less than or equal to 6.39mmol/L, and the blood sugar of the patient is less than or equal to 7.8mmol/L after 2 hours of meal;
effective, the fasting blood sugar of the patient is less than or equal to 7.8mmol/L, and the blood sugar of the patient is less than or equal to 11.1mmol/L after 2 hours of meal;
and (4) invalidation: the patients have no improvement on blood sugar and symptoms.
2. Relationship of glycated hemoglobin to glycemic control:
when the content of the glycosylated hemoglobin is 4% -6%, the blood sugar is normally controlled;
when the content of the glycosylated hemoglobin is 6% -7%, the blood sugar control is ideal;
when the content of the glycosylated hemoglobin is 7% -8%, the blood sugar is generally controlled;
when the content of the glycosylated hemoglobin is 8% -9%, the blood sugar control is not ideal, the blood sugar control needs to be strengthened, the diet structure and the movement are cared for more, and the control scheme is adjusted under the guidance of a doctor;
when the glycated hemoglobin content is more than 9%, blood glucose control is poor, which is a risk factor for the development of chronic complications, and complications such as diabetic nephropathy, arteriosclerosis, cataract, and acute complications such as ketoacidosis may occur.
As is clear from the results in Table 4, the blood glucose control effect was more favorable in the above-mentioned groups of patients treated for 12 weeks. The effect of the cyclocarya paliurus-bitter gourd blood sugar reducing tea bag or the cyclocarya paliurus-bitter gourd blood sugar reducing tea granule for adjuvant therapy of type II diabetes is better than that of singly using glimepiride, metformin hydrochloride and acarbose, and the daily dosage of the medicine can be reduced to one half to two thirds of the original dosage, because the raw materials adopted by the cyclocarya paliurus-bitter gourd blood sugar reducing tea bag and the cyclocarya paliurus-bitter gourd blood sugar reducing tea granule are medicinal and edible raw materials, the tea bag is safe and non-toxic, and after 12 weeks of treatment, adverse reactions do not exist, and the side effects caused by long-term medicine taking are effectively reduced.
Typical case 1
The patient is Zhangzhi, female, 58 years old, 159cm in height, 64Kg in weight, BMI25.3Kg/m2The diagnosis of type II diabetes is more than 2 years, and the main symptoms are thirst, polydipsia and hypodynamia. And (4) checking results: fasting blood glucose: 9.5mmol/L, 13.1mmol/L after 2 hours, 7.1% of glycosylated hemoglobin, liver function, kidney function, blood pressure, blood fat,Hepatitis B virusFive items and urineMeasurement ofProtein four item, chest film, electrocardiogram and liverNo abnormality was found in B-mode ultrasound of gallbladder, spleen and kidney.
The treatment scheme comprises the following steps: the daily dose of the glimepiride is 1mg once a day, and the cyclocarya paliurus bitter gourd blood sugar reducing tea bag obtained in the example 1 is taken orally for 3 bags every day and is drunk after being made into a tea bag.
Examination results after 2 months of treatment: fasting blood glucose: 5.7mmol/L, 8.7mmol/L after 2 hours and 6.1% of glycosylated hemoglobin.
Typical case 2
The patient is a plum, male, 62 years old, 172cm in height, 76Kg in weight and BMI25.6Kg/m2It is diagnosed as type II diabetes more than 3 years, polydipsia, diuresis, intermittent hypodynamia, and unobvious weight increase and decrease. And (4) checking results: fasting blood glucose: 9.6mmol/L, 14.3mmol/L after 2 hours, 7.2% of glycosylated hemoglobin, four items of liver function, kidney function, blood pressure, blood fat, five items of hepatitis B and urine trace protein, chest radiograph, electrocardiogram and B-ultrasound of liver, gallbladder, spleen and kidney.
The treatment scheme comprises the following steps: the metformin hydrochloride is orally taken for treatment, the daily dose is 0.75g, the cyclocarya paliurus-bitter gourd blood sugar reducing tea granules obtained in example 2 are taken twice a day, and the granules are brewed with warm water for drinking.
Examination results after 2 months of treatment: fasting blood glucose: 6.2mmol/L, 9.1mmol/L after 2 hours and 6.3% of glycosylated hemoglobin.
Typical case 3
The patient is Qin and Zhan, woman, 48 years old, 161cm in height, 68Kg in weight, BMI26.2Kg/m2Type II diabetes mellitus is diagnosed as polydipsia, diuresis and intermittent hypodynamia in 2.5 years. And (4) checking results: fasting blood glucose: 9.6mmol/L, 14.3mmol/L after 2 hours, 7.2% of glycosylated hemoglobin, four items of liver function, kidney function, blood pressure, blood fat, five items of hepatitis B and urine trace protein, chest radiograph, electrocardiogram and B-ultrasound of liver, gallbladder, spleen and kidney.
The treatment scheme comprises the following steps: the acarbose is orally taken for treatment, the daily dose is 100mg, the tea bag is taken twice a day, and the cyclocarya paliurus bitter gourd blood sugar reducing tea obtained in example 1 is taken for 3 bags every day and is drunk after being made into tea.
Examination results after 2 months of treatment: fasting blood glucose: 5.9mmol/L, 9.0mmol/L after 2 hours and 6.4% of glycosylated hemoglobin.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (6)
1. The cyclocarya paliurus and bitter gourd auxiliary blood glucose reducing tea is characterized by being prepared from the following raw materials in parts by weight: 6-12 parts of cyclocarya paliurus leaves, 70-80 parts of bitter melons, 4-8 parts of mulberry leaves, 4-8 parts of selfheal, 3-5 parts of wild chrysanthemum flowers and 1-3 parts of scented tea;
or, the composition is prepared from the following raw materials in parts by weight: 15-20 parts of cyclocarya paliurus leaves, 40-50 parts of bitter gourds, 8-15 parts of mulberry leaves, 8-15 parts of selfheal, 8-10 parts of wild chrysanthemum flowers and 3-5 parts of scented tea;
wherein the bitter gourds are the combination of bitter gourd jerky and bitter gourd extract; the balsam pear extract is extracted from balsam pear leaves, balsam pear vines and balsam pear jerky; wherein, the balsam pear leaves: balsam pear vine: the mass ratio of the balsam pear jerky is (1-6) to (1-4) to (2-10);
the bitter gourd extract is prepared by the following method: pulverizing folium Momordicae Charantiae, caulis Momordicae Charantiae and fructus Momordicae Charantiae into 10-30 mesh particles, adding 1-20 times of 50% -90% ethanol, adjusting pH to 6.0-8.0, extracting at 20-50 deg.C for 6-10 hr for 2 times, filtering, and collecting filtrate; adding 1-10 times of 50% -90% ethanol, adjusting pH to 6.0-8.0, extracting at 20-50 deg.C for 6-10 hr, filtering, and collecting filtrate; mixing the three filtrates, vacuum concentrating to relative density of 1.05-1.2 to obtain fructus Momordicae Charantiae extract, and drying to obtain fructus Momordicae Charantiae extract;
the scented tea is one or more selected from jasmine tea, sweet osmanthus tea, chrysanthemum tea or rose tea; wherein the chrysanthemum in the chrysanthemum tea is one or more of chrysanthemum bud, chrysanthemum tribute or chrysanthemum morifolium.
2. The cyclocarya paliurus-bitter gourd auxiliary blood glucose reduction tea as claimed in claim 1, is prepared from the following raw materials in parts by weight: 8 parts of cyclocarya paliurus leaves, 76 parts of bitter melons, 5 parts of mulberry leaves, 5 parts of selfheal, 4 parts of wild chrysanthemum flowers and 2 parts of scented tea;
or, the composition is prepared from the following raw materials in parts by weight: 18 parts of cyclocarya paliurus leaves, 45 parts of bitter gourds, 11 parts of mulberry leaves, 11 parts of selfheal, 10 parts of wild chrysanthemum flowers and 5 parts of scented tea.
3. The cyclocarya paliurus-bitter gourd auxiliary blood-glucose-reducing tea as claimed in claim 1 or 2, wherein the cyclocarya paliurus-bitter gourd blood-glucose-reducing tea is prepared into granules or tea bags according to requirements;
when the cyclocarya paliurus and bitter gourd blood sugar-reducing tea is a tea bag, the bitter gourd leaves are: balsam pear vine: the mass ratio of the balsam pear jerky is 3:3: 4; when the cyclocarya paliurus-bitter gourd blood sugar-reducing tea is granules, the bitter gourd leaves are: balsam pear vine: the mass ratio of the balsam pear jerky is 1:1: 6.
4. The cyclocarya paliurus-bitter gourd auxiliary blood-glucose-reducing tea as claimed in claim 3, wherein the granules are prepared by a method comprising the following steps of: weighing cyclocarya paliurus leaves, folium mori, selfheal, wild chrysanthemum flower and scented tea in proportion, extracting respectively or extracting after mixing, mixing the obtained total extract with bitter melons and food additives, granulating, sieving, drying, sterilizing and packaging to obtain the finished product.
5. The cyclocarya paliurus-bitter gourd auxiliary blood glucose reduction tea as claimed in claim 3, wherein the tea bag is prepared by the following method: mixing cyclocarya paliurus leaves, bitter gourds, mulberry leaves, selfheal, wild chrysanthemum flowers and scented tea in proportion, and granulating, wherein the bitter gourds are bitter gourd extracts and bitter gourd jerky, and the weight ratio of the bitter gourd extracts to the bitter gourd jerky is 1: 8-9, sieving the obtained granules, drying, sterilizing and packaging to obtain the finished product.
6. The use of the cyclocarya paliurus-bitter gourd auxiliary blood-glucose-reducing tea of any one of claims 1 to 5 in the preparation of health-care food.
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