CN106692297A - Composition for assistedly decreasing blood sugar, and preparation method and application thereof - Google Patents
Composition for assistedly decreasing blood sugar, and preparation method and application thereof Download PDFInfo
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- CN106692297A CN106692297A CN201710080001.5A CN201710080001A CN106692297A CN 106692297 A CN106692297 A CN 106692297A CN 201710080001 A CN201710080001 A CN 201710080001A CN 106692297 A CN106692297 A CN 106692297A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a composition for efficiently assistedly decreasing blood sugar, and a preparation method and an application thereof. The composition is composed of 400 to 500 parts by weight of a cyclocarya paliurus extract, 200 to 300 parts by weight of a horseradish tree leaf ultramicro wall-broken fine powder, 120 to 240 parts by weight of a mulberry leaf extract and 80 to 160 parts by weight of a bitter gourd extract. The content of cyclocarya paliurus total flavonoids is 8-16% and the content of polysaccharides is 12 to 28%; horseradish tree leaves are subjected to low-temperature airflow crushing to obtain the ultramicro wall-broken powder; the content of total flavonoids of the mulberry leaf extract is 2% to 15%, and the content of DNJ is 1% to 2%; the content of charantin of the bitter gourd extract is 5% to 20%. Tests indicate that the composition can significantly reduce the blood sugar of diabetic mice, can significantly enhance the glucose tolerance of the diabetic mice, and has important significance for research and development of hypoglycemic drugs, health food, functional ordinary food, special medical food and special dietary food.
Description
Technical field
The present invention relates to a kind of composition of efficient auxiliary hyperglycemic.More particularly to blue or green money willow extract, leaf of Moringa ultra micro
Compatible composition of broken wall fine powder, mulberry-leaf extract and Bitter Melon P.E and its preparation method and application.
Technical background
Due to the continuous improvement of people's living standard, the change of dietary structure, more and more nervous rhythm of life and few
The factors influences such as the dynamic life style sat, global onset diabetes rate increases very fast more.According to statistics, diabetes into
It is the chronic disease of the third-largest serious threat human health after tumour, cardiovascular and cerebrovascular disease.Diabetes are one kind due to blood
The sugar whole body progressive disease being higher by caused by normal level out of control, 0 complication is more and serious, and clinical treatment removes insulin injection
Outward, there is certain side effect and body injury in predominantly oral sulfonylureas, biguanides hypoglycemic drug.At present, blood is effectively reduced
The life enhancement class product that sugar, auxiliary prevent and treat diabetes is less, with national " preventiveing treatment of disease " big health industry policy less
It is consistent.
Qingqian Willow leaf defends the new resource food (notification number of planning commission (the former Ministry of Public Health) approval for country：2013 No. 10),
Leaf of Moringa defends the new resource food (notification number of planning commission (the former Ministry of Public Health) approval for country：2012 No. 19).Mulberry leaf and balsam pear
Homologous material is eaten as traditional medicine, the traditional Chinese medical science is just using mulberry leaf as treatment diabetes (i.e. the diabetes of modern medicine) since ancient times
Application in TCM in clinic, Japanese ancient book《Eat tea health note》Also recording mulberry leaf has improvement " drinking-water disease " (the i.e. glycosuria of modern medicine
Disease) effect.In addition, China just utilizes balsam pear as medicinal plant since ancient times,《Herbal for Relief of Famines》With《Herbal guiding principle
Mesh》In Deng ancient documents, balsam pear is all once mentioned；In terms of diabetes, all emphasize it " can quench the thirst ", " cure mainly polydipsia and draw drink "
Deng.
《A kind of tea bag containing leaf of Moringa and preparation method thereof》(patent application publication number：CN105519721A) disclose
A kind of tea bag containing leaf of Moringa and preparation method thereof.Its formula include Qingqian Willow leaf, 0.1 that mass fraction is 1~2.8 part~
1.0 parts of leaf of Moringa and 0.1~0.5 part of six fort tealeaves, additionally providing this kind of preparation method of tea bag includes crushing, mixes
The steps such as conjunction, granulation, whole bag, specification is not directed to component and extracts and Quality Control Technology enlightenment；《One kind was both significantly improved
Blood pressure and blood lipoid can rapidly supplement the health food compound method that human body must be micro- again》(patent application publication number：
CN105851360A a kind of health care food for not only having significantly improved blood pressure and blood lipoid but also rapidly having supplemented the necessary trace element of human body) is disclosed
Product compound method.Its formula is by 10~40 parts of ampelopsis grossdentata leaves of parts by weight, 10~40 parts of Qingqian Willow leafs, 10~40 parts of Moringas
Leaf is constituted, and specification is not directed to technological parameter and Quality Control Technology enlightenment.
It is contemplated that using new resource food raw material Qingqian Willow leaf, leaf of Moringa and traditional integration of drinking and medicinal herbs mulberry leaf, balsam pear group
Side, it is specific composition thing of the present invention to be enriched with by technical schemes such as special process parameter of the present invention, raw material qualification, quality controls
Matter, then the composition of blood sugar is significantly reduced by special ratios of the present invention preparation.Experiment proves have significantly to diabetic mice
Pharmacological action that is hypoglycemic, significantly increasing diabetic mice sugar tolerance.
The content of the invention
The first object of the present invention is to provide a kind of composition of efficient auxiliary hyperglycemic and preparation method thereof.Second mesh
Be provide said composition application.
The first object of the present invention is realized using following technical scheme.
First, the present invention provides a kind of composition of efficient auxiliary hyperglycemic, the composition by parts by weight 400~
500 parts of blue or green money willow extract, the leaf of Moringa super-micro wall-broken fine powder of 200~300 parts of parts by weight, 120~240 parts of parts by weight
Mulberry-leaf extract and 60~180 parts of parts by weight Bitter Melon P.E composition.
Preferably, the composition by 420~480 parts of parts by weight blue or green money willow extract, parts by weight 220~280
The hardship of 80~160 parts of the leaf of Moringa super-micro wall-broken fine powder, the mulberry-leaf extract of 140~220 parts of parts by weight and parts by weight of part
Melon extract is constituted.
Further preferably, the composition by the blue or green money willow extract of 440~460 parts of parts by weight, parts by weight 240~
100~140 parts of 260 parts of leaf of Moringa super-micro wall-broken fine powder, the mulberry-leaf extract of 160~200 parts of parts by weight and parts by weight
Bitter Melon P.E composition.
Most preferably, the composition is by the blue or green money willow extract of 450 parts of parts by weight, the leaf of Moringa of 250 parts of parts by weight
The Bitter Melon P.E composition of 120 parts of super-micro wall-broken fine powder, the mulberry-leaf extract of 180 parts of parts by weight and parts by weight.
Secondly, blue or green money willow extract system of the present invention, with Qingqian Willow leaf as raw material, is 20~40 mesh meal through meal, is adopted
With mass volume ratio (g/ml)=1:3rd, concentration is that 70~80% ethanol extract 2-3 times (80 DEG C of temperature control, 2~4h of extraction time),
Collection extract solution is concentrated under reduced pressure into relative density 1.05 (20 DEG C determine) must contain flavones and saponin(e concentrate；Residue is added after weighing
Mass volume ratio (g/ml) 1：8~8.5 purifying water boiling and extractions 2 times (90 DEG C of temperature control, 2~3h of extraction time), collect extract solution
Being concentrated under reduced pressure into relative density 1.23 (20 DEG C determine) must contain polysaccharide concentrate；2 concentrates of mixing, it is concentrated, dry to be obtained
Blue or green money willow extract.Blue or green money willow extractive total flavone content 8~16%, polyoses content 12~28%, be preferably 14%~26%,
More preferably 16~24%
Again, leaf of Moringa super-micro wall-broken fine powder system of the present invention uses low-temperature airflow crushing technology, will dry Moringa
Leaf is ground into 800~1200 mesh under the conditions of 20 DEG C of ﹣, liquid nitrogen and is obtained.
In addition, mulberry-leaf extract of the present invention, Bitter Melon P.E system use food-grade or pharmaceutical grade raw material.Wherein, mulberry
Leaf extract quality control index is limited to：DNJ contents 1%~2%, general flavone content 2%~15%, be preferably 4%~
12%th, more preferably 5%~10%.Bitter Melon P.E quality control index is limited to：Balsam pear salidroside content 5%~20%, preferably
It is 8%~17%, more preferably 10%~15%.
Finally, blue or green money willow extract, leaf of Moringa super-micro wall-broken essence are weighed by parts by weight of the present invention and preferred weight number
Powder, food or pharmaceutical grade mulberry-leaf extract and Bitter Melon P.E, the mesh sieve of size-reduced mistake 80~100, in clean rustless steel container
It is uniform through being thoroughly mixed, obtain final product the present composition.
The second object of the present invention is realized using following technical scheme.
First, composition of the present invention can be used for the medicine of assisting in reducing blood sugar, health food, feature and commonly eat
In product, special medicine food, special diet food.
Secondly, composition of the present invention can be directly prepared into powder, granule, hard shell capsules, tablet without any auxiliary material
Deng solid orally ingestible；Also one or more that can be added in water, rice vinegar etc. are prepared into the water-bindered pill as excipient；Can also add
Water, a- cyclodextrin, beta-schardinger dextrin, sodium carboxymethylcellulose, starch, microcrystalline cellulose, PVP, PEG-4000, PEG-6000,
One or more in magnesium stearate, medicinal or food vegetable fat etc. are further made granule, tablet, hard shell capsules, flexible glue
The preparations such as capsule, pill.
Specific embodiment：
Below by specific embodiment, the invention will be further described, but the present invention limited never in any form
System, based on present invention teach that any change or replacement made, belong to the scope of the present invention.
Embodiment 1：It is prepared by blue or green money willow extract
Qingqian Willow leaf is taken, 24 mesh sieves are crossed after removal of impurities, drying, crushing.Weigh during 10kg Qingqian Willow leaf meal puts extractor, add
Plus mass volume ratio (g/ml)=1:3rd, concentration is that 75% alcohol heat reflux extracts 2 times (80 DEG C of temperature control, every time 3 hours), is merged
Extract solution is concentrated under reduced pressure into relative density 1.05 (20 DEG C of measure) twice, obtains the concentrate containing flavones and saponin component；Ethanol
Residual residue is weighed after circumfluence distillation, addition mass volume ratio (g/ml)=1：8 purified waters decoct 2 times (90 DEG C of temperature control, every time
Extract 2 hours), No. 2 extract solutions of merging are concentrated under reduced pressure into contrast 1.23 (20 DEG C determine) must contain the concentrate of polysaccharide component；
Merge alcohol heat reflux, water decocting and concentrating liquid, concentrated, dry blue or green money willow extract 2.5kg, after testing：General flavone content
15%th, polyoses content 21%.
Brief description of the drawings：Fig. 1 is blue or green money willow extract extraction process flow chart
Embodiment 2：It is prepared by leaf of Moringa super-micro wall-broken fine powder
Liquid nitrogen air-flow Lowtemperaturepulverizer (high bridge/M-250 types) start is cooled to 20 DEG C of ﹣ in advance, is weighed and is dried leaf of Moringa (moisture
The 1.5kg of content≤10%) is put in pulverizer, and start is crushed to 1000 mesh, obtains leaf of Moringa super-micro wall-broken fine powder 1.25kg.
Embodiment 3：Mulberry-leaf extract, Bitter Melon P.E prepare
It is 1 to purchase specification:10 food-grade mulberry-leaf extract 1.5kg.Self-inspection flavones content 6%, DNJ contents 1.8%.
Purchase charantin content >=10% food-grade Bitter Melon P.E (Q/HLB031-2013) 1kg.Self-inspection balsam pear salidroside content
13%.
Embodiment 4：Composition prepares 1
Example 1 prepare blue or green money willow extract 400g, embodiment 2 prepare leaf of Moringa super-micro wall-broken fine powder 300g,
Mulberry-leaf extract 240g and Bitter Melon P.E 60g that embodiment 3 prepares, crushed 80 mesh sieves, were filled in clean rustless steel container
Divide and be uniformly mixed, obtain composition 996g.
Embodiment 5：Composition prepares 2
Example 1 prepare blue or green money willow extract 420g, embodiment 2 prepare leaf of Moringa super-micro wall-broken fine powder 280g,
Mulberry-leaf extract 220g and Bitter Melon P.E 80g that embodiment 3 prepares, crushed 100 mesh sieves, were filled in clean rustless steel container
Divide and be uniformly mixed, obtain composition 991g.
Embodiment 6：Composition prepares 3
Example 1 prepare blue or green money willow extract 450g, embodiment 2 prepare leaf of Moringa super-micro wall-broken fine powder 250g,
Mulberry-leaf extract 180g and Bitter Melon P.E 120g that embodiment 3 prepares, crushed 80 mesh sieves, were filled in clean rustless steel container
Divide and be uniformly mixed, i.e. composition 995g.
Embodiment 7：Composition prepares 4
Example 1 prepare blue or green money willow extract 480g, embodiment 2 prepare leaf of Moringa super-micro wall-broken fine powder 220g,
Mulberry-leaf extract 160g and Bitter Melon P.E 140g that embodiment 3 prepares, crushed 100 mesh sieves, in clean rustless steel container
It is thoroughly mixed uniform, i.e. composition 989g.
Embodiment 8：Composition prepares 5
Example 1 prepare blue or green money willow extract 500g, embodiment 2 prepare leaf of Moringa super-micro wall-broken fine powder 200g,
Mulberry-leaf extract 120g and Bitter Melon P.E 180g that embodiment 3 prepares, crushed 100 mesh sieves, in clean rustless steel container
It is thoroughly mixed uniform, i.e. composition 993g.
Embodiment 9：It is prepared by hard shell capsules
Composition 100g prepared by Example 6, through wet granulation, drying, filling, is obtained the ebonite of auxiliary hyperglycemic
Capsule.
Embodiment 10：It is prepared by the water-bindered pill
Composition 100g prepared by Example 7, using purified water, rice vinegar as excipient, is made auxiliary hyperglycemic
The water-bindered pill.
Embodiment 11：It is prepared by granule
Composition 200g prepared by Example 6, addition appropriate amount of starch, sodium carboxymethylcellulose, powder-beta-dextrin, through wet method system
Softwood, extruding sieving, dry, whole grain is made the granule of auxiliary hyperglycemic.
Embodiment 12：It is prepared by tablet
Composition 200g prepared by Example 6, addition appropriate amount of starch, PVP, magnesium stearate through wet granulation, are done
Dry, compressing tablet is obtained the tablet of auxiliary hyperglycemic.
In order to the technique effect further to the present composition is illustrated, the present invention chooses prepared by embodiment 1
Leaf of Moringa super-micro wall-broken fine powder, the mulberry-leaf extract of the preparation of embodiment 3 and balsam pear prepared by blue or green money willow extract, embodiment 2 is carried
The composition that thing and four non-invention portfolio ratios are prepared by embodiment 7 is taken (to be surpassed by blue or green money willow extract 200g, leaf of Moringa
Micro- broken wall fine powder 500g, mulberry-leaf extract 60g, Bitter Melon P.E 240g are mixed) used as control sample, numbering is followed successively by
①、②、③、④、⑤；The composition prepared by embodiment 6 is chosen as test specimen, 6. numbering is；Choose diabetes pill
(Xiaoke Pill, XKP, Guangzhou No.1 Chinese Pharmacy Factory) is used as positive control medicine；Simultaneously set blank control group, model control group with
Exclude modeling interference and error.Carry out the experiment of mouse hypoglycemic and carbohydrate tolerance test simultaneously, it is as a result as follows：
Experimental animal and equipment：Healthy Male Kunming strain mice (26 ± 2g of body weight)；The 5% alloxan aqueous solution (faces use
Newly match somebody with somebody), blood sugar detection kit (by specification is used), full-automatic biochemical detector, 721-B type ultraviolet specrophotometers.
Give sample dosage：Composition (test specimen is 6.) 60kg adult of the present invention is defined as 7g/ days to sample dosage, according to
This daily mouse of conversion is 1.05g/kg BW to sample dosage.The dosage such as foundation determine that control sample is 5. daily to sample than principle
It is 1.05g/kg BW to sample dosage, with reference to the day highest recommended amounts of diabetes pill (Xiaoke Pill, XKP, Guangzhou No.1 Chinese Pharmacy Factory)
Determine that positive controls diabetes pill is daily 1.05g/kgBW to sample amount.According to etc. dosage to sample than principle, with reference to national medicine
Allusion quotation or the blue or green money willow extract of relevant industries standard recommendation, leaf of Moringa, mulberry-leaf extract, Bitter Melon P.E highest day recommended dose
Determine control sample 1.~be 4. 1.05g/kgBW to sample dosage.
Modeling and packet：Healthy Male Kunming strain mice 400 is chosen, 20 is randomly selected and is only used as blank group (NC), remained
Remaining and 380 be served only for modeling.Before modeling, all animal fasting 48h (free water), 380 modeling mouse tail vein injections (iv)
The dosage physiological saline such as injection 80mg/ ㎏ BW alloxans, blank group injection, injection finishes rear 30s and recovers to food, normal to raise
5 days, fasting 5h, from 380 modeling mouse orbit venous blood collection 0.05ml, EDTA anti-freezings, centrifuging and taking determination of plasma fasting blood-glucoses
Value, blood sugar is that hyperglycaemia modeling success animal is used to test higher than 13mmol/L person.334 mouse modeling successes are had, therefrom
320 are chosen to be randomly divided into 8 groups (every group of 2 repetitions, each repeats 20).Set up model group (TNB), diabetes pill positive control separately
Group (XKP), experiment 1.~6. group.
Reduce fasting blood-glucose experiment：The daily gavage sample of test group 1.~6. sample 1.05g/kg BW, positive control are filled daily
The daily isometric distilled water of gavage respectively of stomach XKP 1.05g/kg BW, TNB and NC group (being fasting 5h before gavage), long run test 6
In week, in being weighed after last day gavage weekly and surveying fasting blood-glucose, result of the test is shown in Tables 1 and 2.
Sugar tolerance is tested：After long run test 6 weeks, blood glucose value when collection last fasting blood-glucose is as 0h.Each group is filled respectively again
Stomach glucose solution 2g/kg BW, to 0.5 after glucose, 1,2h from mouse orbit venous blood collection, blood glucose value is determined respectively, test
The results are shown in Table 3.
Table 1：Test mice body weight determination result
Table 2：Test mice fasting blood-glucose testing result
Table 3：Test mice sugar tolerance testing result
Remarks：In table 1~3, TNB groups, XKP groups, 1.~6. organize 2 repetitions between mouse blood sugar value there was no significant difference, system
Timing is merged.
Table 1~3 is found out：During off-test, experiment 6. group compared to TNB groups, experiment 1.~5. group Mouse Weight, fasting blood
Sugared value, carbohydrate tolerance test result have height significant difference (P ＜ 0.01), test 6. group compared to XKP groups Mouse Weight, sky
Abdomen blood glucose value, carbohydrate tolerance test result have significant difference (P ＜ 0.05).The display present composition (test specimen is 6.) phase
Compared with sample 1.~5., diabetic mice body weight can be significantly improved, fasting blood-glucose is significantly reduced, significantly increased alloxan glycosuria
Sick mouse glucose tolerance ability, its pharmacological activity is better than classical antidiabetic drug diabetes pill.
To sum up, composition of the present invention can significantly improve the Body weight loss of tentative diabetic mice, quick reduction sky
Abdomen blood sugar, significantly increase sugar tolerance effect.Its pharmacological activity is better than positive control drug diabetes pill, for auxiliary hyperglycemic, glycosuria
Disease prevention and treatment medicine, health food, feature ordinary food, special medicine food, special diet food research exploitation tool
There is meaning of crucial importance.
Claims (10)
1. a kind of composition of efficient auxiliary hyperglycemic.It is characterized in that：The composition is by 400~500 parts of parts by weight
Blue or green money willow extract, the leaf of Moringa super-micro wall-broken fine powder of 200~300 parts of parts by weight, the mulberry leaf of 120~240 parts of parts by weight
The Bitter Melon P.E composition of 60~180 parts of extract and parts by weight.
2. composition according to claim 1, it is characterised in that：The composition by 420~480 parts of parts by weight blue or green money
Willow extract, the leaf of Moringa super-micro wall-broken fine powder of 220~280 parts of parts by weight, the mulberry leaf of 140~220 parts of parts by weight are extracted
The Bitter Melon P.E composition of 80~160 parts of thing and parts by weight.
3. composition according to claim 1, it is characterised in that：The composition by 440~460 parts of parts by weight blue or green money
Willow extract, the leaf of Moringa super-micro wall-broken fine powder of 240~260 parts of parts by weight, the mulberry leaf of 160~200 parts of parts by weight are extracted
The Bitter Melon P.E composition of 100~140 parts of thing and parts by weight.
4. composition according to claim 1, it is characterised in that：The composition is carried by the blue or green money willow of 450 parts of parts by weight
Take the mulberry-leaf extract and parts by weight 120 of thing, the leaf of Moringa super-micro wall-broken fine powder of 250 parts of parts by weight, 180 parts of parts by weight
The Bitter Melon P.E composition of part.
5. composition according to claims 1 to 4, it is characterised in that：The blue or green money willow extract system is with Qingqian Willow leaf as former
Material, it is size-reduced to 20~40 mesh, using mass volume ratio (g/ml) 1:3rd, the alcohol heat reflux of concentration 70~80% is extracted 2~3 times
(80 DEG C of temperature control, 2~4h of extraction time), collect extract solution be concentrated under reduced pressure into relative density 1.05 (20 DEG C determine) must contain flavones and
Saponin(e concentrate；Residue adds mass volume ratio (g/ml) 1 after weighing：8~8.5 purifying water boiling and extractions 2 times (90 DEG C of temperature control,
2~3h of extraction time), collect the concentrate containing polysaccharide that extract solution is concentrated under reduced pressure into relative density 1.23 (20 DEG C of measure)；Mixing 2
Secondary concentrate, concentrated, dry prepared blue or green money willow extract.Blue or green money willow extractive total flavone content 8~16%, polyoses content 12
~28%, 14%~26%, more preferably 16~24% are preferably.
6. composition according to claims 1 to 4, it is characterised in that：The leaf of Moringa super-micro wall-broken fine powder system uses low temperature
Airflow pulverization, 800~1200 mesh is crushed under the conditions of liquid nitrogen, 20 DEG C of ﹣ and is obtained.
7. composition according to claims 1 to 4, it is characterised in that：The mulberry-leaf extract is food or pharmaceutical grade raw material.
Wherein, DNJ contents 1%~2%, general flavone content 2%~15%, preferably 4%~12%, more preferably 5%~10%.
8. composition according to claims 1 to 4, it is characterised in that：The Bitter Melon P.E is food or pharmaceutical grade raw material.
Wherein, balsam pear salidroside content 5%~20%, preferably 8%~17%, more preferably 10%~15%.
9. composition according to claims 1 to 8, it is characterised in that：The composition can be applied to assisting in reducing blood sugar
Medicine, health food, feature ordinary food, special medicine food, special diet food.
10. composition according to claims 1 to 9, it is characterised in that：The composition can be added or without medicine, guarantor
Health food, feature ordinary food, special medicine formula food, the acceptable auxiliary material of special diet food, are further made scattered
The preparations such as agent, tablet, granule, hard shell capsules, soft capsule, the water-bindered pill.
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| CN107136269A (en) * | 2017-06-29 | 2017-09-08 | 北京颐方生物科技有限公司 | A kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof |
| CN108283285A (en) * | 2017-12-31 | 2018-07-17 | 深圳市金乐智能健康科技有限公司 | A kind of health-care physiotherapeutic food of diabetes |
| CN108935842A (en) * | 2018-06-28 | 2018-12-07 | 华南农业大学 | A kind of preparation and application of balsam pear blue or green money willow lipid-lowering health-care tea |
| CN109463685A (en) * | 2018-11-22 | 2019-03-15 | 河南农业大学 | A kind of preparation method and health care product of woody hypoglycemic composition |
| CN109875047A (en) * | 2019-04-04 | 2019-06-14 | 云南农业大学 | A kind of wheaten food auxiliary additive for alleviating anorectal disease |
| CN109966417A (en) * | 2017-12-28 | 2019-07-05 | 随州市万松堂康汇保健品有限公司 | A kind of solid beverage for diabetic population |
| CN110051726A (en) * | 2019-04-16 | 2019-07-26 | 浙江大学 | The preparation method and application of general flavone and total starches in a kind of Qingqian Willow leaf |
| CN112352895A (en) * | 2020-11-02 | 2021-02-12 | 辽宁康汇医学临床研究有限公司 | Angelica keiskei plant herbaceous solid beverage assisting in reducing blood sugar and preparation method thereof |
| CN112569300A (en) * | 2020-12-29 | 2021-03-30 | 深圳可弘生物科技有限公司 | Composition and preparation for reducing blood sugar, preparation method and application thereof |
| CN112970923A (en) * | 2021-04-19 | 2021-06-18 | 广州王老吉餐饮管理发展有限公司 | Plant extract for flavoring syrup |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107136269A (en) * | 2017-06-29 | 2017-09-08 | 北京颐方生物科技有限公司 | A kind of blue or green money willow bitter gourd sugar-reducing tea and preparation method thereof |
| CN109966417A (en) * | 2017-12-28 | 2019-07-05 | 随州市万松堂康汇保健品有限公司 | A kind of solid beverage for diabetic population |
| CN108283285A (en) * | 2017-12-31 | 2018-07-17 | 深圳市金乐智能健康科技有限公司 | A kind of health-care physiotherapeutic food of diabetes |
| CN108935842A (en) * | 2018-06-28 | 2018-12-07 | 华南农业大学 | A kind of preparation and application of balsam pear blue or green money willow lipid-lowering health-care tea |
| CN109463685A (en) * | 2018-11-22 | 2019-03-15 | 河南农业大学 | A kind of preparation method and health care product of woody hypoglycemic composition |
| CN109875047A (en) * | 2019-04-04 | 2019-06-14 | 云南农业大学 | A kind of wheaten food auxiliary additive for alleviating anorectal disease |
| CN110051726A (en) * | 2019-04-16 | 2019-07-26 | 浙江大学 | The preparation method and application of general flavone and total starches in a kind of Qingqian Willow leaf |
| CN112352895A (en) * | 2020-11-02 | 2021-02-12 | 辽宁康汇医学临床研究有限公司 | Angelica keiskei plant herbaceous solid beverage assisting in reducing blood sugar and preparation method thereof |
| CN112569300A (en) * | 2020-12-29 | 2021-03-30 | 深圳可弘生物科技有限公司 | Composition and preparation for reducing blood sugar, preparation method and application thereof |
| CN112970923A (en) * | 2021-04-19 | 2021-06-18 | 广州王老吉餐饮管理发展有限公司 | Plant extract for flavoring syrup |
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