CN107108747A - 具有共同轻链的双特异性抗体或抗体混合物 - Google Patents

具有共同轻链的双特异性抗体或抗体混合物 Download PDF

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Publication number
CN107108747A
CN107108747A CN201680005167.4A CN201680005167A CN107108747A CN 107108747 A CN107108747 A CN 107108747A CN 201680005167 A CN201680005167 A CN 201680005167A CN 107108747 A CN107108747 A CN 107108747A
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antigen
antibody
light chain
binding portion
sequence
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CN107108747B (zh
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徐霆
须涛
汪皛皛
李倩
逄敏洁
张慧敏
韩莉
张庆青
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Jiangsu Corelle Jerry biopharmaceutical Co., Ltd.
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Suzhou Alphamab Co Ltd
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

本发明提供了具有共同轻链的双特异性抗体或抗体混合物及其制备方法。本发明还提供了编码所述抗体或混合物的核酸分子、含有该核酸分子的重组载体和重组细胞，以及所述抗体或混合物的检测和定量方法。

Description

PCT国内申请，说明书已公开。

Claims (45)

  1. PCT国内申请，权利要求书已公开。
CN201680005167.4A 2015-01-08 2016-01-08 具有共同轻链的双特异性抗体或抗体混合物 Active CN107108747B (zh)

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CN202111616341.8A CN114276458A (zh) 2015-01-08 2016-01-08 具有共同轻链的双特异性抗体或抗体混合物

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CN201510008045.8A CN105820251B (zh) 2015-01-08 2015-01-08 具有共同轻链的双特异性抗体或抗体混合物
CN2015100080458 2015-01-08
PCT/CN2016/070447 WO2016110267A1 (zh) 2015-01-08 2016-01-08 具有共同轻链的双特异性抗体或抗体混合物

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CN107108747B CN107108747B (zh) 2022-02-08

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CN201910869921.4A Active CN110658340B (zh) 2015-01-08 2015-01-08 具有共同轻链的双特异性抗体或抗体混合物
CN201910857990.3A Active CN110655582B (zh) 2015-01-08 2015-01-08 具有共同轻链的双特异性抗体或抗体混合物
CN201680005167.4A Active CN107108747B (zh) 2015-01-08 2016-01-08 具有共同轻链的双特异性抗体或抗体混合物
CN202111616341.8A Pending CN114276458A (zh) 2015-01-08 2016-01-08 具有共同轻链的双特异性抗体或抗体混合物

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CN201910869921.4A Active CN110658340B (zh) 2015-01-08 2015-01-08 具有共同轻链的双特异性抗体或抗体混合物
CN201910857990.3A Active CN110655582B (zh) 2015-01-08 2015-01-08 具有共同轻链的双特异性抗体或抗体混合物

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US (2) US10808043B2 (zh)
EP (1) EP3243840B8 (zh)
JP (1) JP7041516B2 (zh)
CN (5) CN105820251B (zh)
DK (1) DK3243840T3 (zh)
ES (1) ES2811267T3 (zh)
WO (1) WO2016110267A1 (zh)

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CN110799546A (zh) * 2017-09-01 2020-02-14 四川科伦博泰生物医药股份有限公司 重组双特异性抗体
WO2022179507A1 (en) * 2021-02-23 2022-09-01 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Methods of preventing, alleviating or treating tumors

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JP2022527860A (ja) * 2019-04-02 2022-06-06 ケンジョッケティ バイオテクノロジー，インク． 排出ポンプ－癌抗原マルチ特異性抗体ならびにそれに関する組成物、試薬、キットおよび方法
CN114269781A (zh) * 2019-12-04 2022-04-01 江苏康宁杰瑞生物制药有限公司 双特异性融合蛋白与抗Her2抗体的组合用于肿瘤治疗
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CN113563473A (zh) * 2020-04-29 2021-10-29 三生国健药业（上海）股份有限公司 四价双特异性抗体、其制备方法和用途
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US20230406921A1 (en) * 2020-11-12 2023-12-21 Mabwell (shanghai) Bioscience Co., Ltd. Antibody and preparation method therefor
CN114539413A (zh) * 2020-11-25 2022-05-27 三生国健药业（上海）股份有限公司 结合her2的多价双特异性抗体、其制备方法和用途
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