CN106925595A - A kind of handling process of antibiotic bacterium dregs - Google Patents
A kind of handling process of antibiotic bacterium dregs Download PDFInfo
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- CN106925595A CN106925595A CN201511021128.7A CN201511021128A CN106925595A CN 106925595 A CN106925595 A CN 106925595A CN 201511021128 A CN201511021128 A CN 201511021128A CN 106925595 A CN106925595 A CN 106925595A
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- Prior art keywords
- antibiotic bacterium
- bacterium dregs
- acid
- handling process
- antibiotic
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- 241000894006 Bacteria Species 0.000 title claims abstract description 156
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- 238000000034 method Methods 0.000 title claims abstract description 116
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- 238000006731 degradation reaction Methods 0.000 claims description 30
- 230000015556 catabolic process Effects 0.000 claims description 25
- 239000002253 acid Substances 0.000 claims description 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 15
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
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- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 description 1
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- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/40—Destroying solid waste or transforming solid waste into something useful or harmless involving thermal treatment, e.g. evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B5/00—Operations not covered by a single other subclass or by a single other group in this subclass
Landscapes
- Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fertilizers (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
The present invention relates to the process field of organic waste, a kind of handling process of antibiotic bacterium dregs is disclosed, wherein, the handling process includes：In the presence of acidic materials, and in confined conditions, at 40-260 DEG C, pending antibiotic bacterium dregs are degraded, catabolite is then carried out into the gentle phase material stream of isolated solid formation mass flow, and gaseous substance stream is post-processed.By above-mentioned technical proposal, Organic nutrient therein can be effectively retained while the residual antibiotic in effectively degraded antibiotic bacterium dregs, for the innoxious use of bacteria residue provides good precondition.Furthermore, technique of the invention can be prevented effectively from the problem that bacteria residue discharges bad smell in processing procedure and after treatment, and the bacteria residue odorless after treatment is environment-friendly.
Description
Technical field
The present invention relates to a kind of handling process of organic waste, in particular it relates to a kind of antibiotic bacterium dregs
Handling process.
Background technology
Antibiotic bacterium dregs are the solid waste of generation during Production by Microorganism Fermentation antibiotic.China
It is the first big country of antibiotics production, it is current country's antibiotic that the green of antibiotic bacterium dregs is degraded and utilized
A major challenge that manufacturing enterprise faces.
Antibiotic bacterium dregs are main by being blended in microbial cells tissue, culture medium, the production technology of residual
Solids phase residue in culture medium, such as filter aid are constituted.The composition of the antibiotic bacterium dregs includes：Source
Protein, fat in microorganism and culture medium, carbohydrate, chitin, vitamin, mineral matter
And the antibiotic of residual etc..Wherein, the moisture of antibiotic bacterium dregs ordinarily be about 70-95 weight %.
The ratio of crude protein is in 30-50 weight % or so in solid waste butt, carbohydrate such as cellulose,
The other compositions such as chitin, mineral matter account for the 40-70 weight % of solid waste butt, antibiotic
Residual concentration is general between 0.05-6 weight ‰.
At present, antibiotic bacterium dregs are according to hazardous waste disposal.Prior art provides the various ways for utilizing
Footpath：As CN104263451A provides a kind of bacteria residue green polymerization fuel and preparation method thereof, the method is proposed
Antibiotic bacterium dregs and coal slime and dimerization fuel are prepared as fuel and the scheme burned.
And for example CN104086244A provides the side that a kind of antibiotic bacterium dregs biofermentation converts humus
Method, the method carries out solid state fermentation using complex microorganism to material, wherein, the material includes antibiosis
Plain bacteria residue and stalk；The complex microorganism includes Trichoderma, bacillus subtilis and bacillus licheniformis,
And the Trichoderma, the weight ratio between bacillus subtilis and bacillus licheniformis are
(3-5):(2-4):(2-4).The method is used by solid fermentation by using bacteria residue as organic fertilizer raw material.
And for example CN103923599A provides a kind of adhesive prepared based on antibiotic bacterium dregs and bean powder
And preparation method thereof, the raw material of the adhesive includes antibiotic bacterium dregs, bean powder and additive.The method
What is proposed is by the scheme of the materialized application of antibiotic bacterium dregs.
Although the existing treatment technology of antibiotic bacterium dregs include incineration technology, Fertilizer Transformed technology, landfill and
Energy technology etc..However, the treatment of antibiotic bacterium dregs still suffers from lot of challenges.Firstly, for bacterium
The antibiotic remained in slag, in addition to burning and carbonization is heat-treated, is difficult to effectively in prior art solutions
Degraded, can reenter environment, as the hotbed for cultivating drug-resistant microorganisms.Second, antibiotic bacterium dregs
Stacking and processing procedure can discharge bad smell, surrounding environment is polluted so that the mistake for the treatment of
Journey faces bigger technical difficulty.
The content of the invention
The purpose of the present invention is to overcome defect of the prior art and provide a kind for the treatment of of antibiotic bacterium dregs
Technique, the handling process can effectively reduce the residual concentration of various antibiotic so that at this programme
The bacteria residue of reason meets the requirement of innoxious use, and can effectively improve the protein content in bacteria residue.
It was found by the inventors of the present invention that using burning and carbonization heat-treating methods, although can remove anti-
Raw element residual, but, the Organic nutrient such as thick protein, amino acid and other organic substances can not
Retained.And handling process of the invention can effectively remove residual antibiotic, nutrients can be retained again
Matter, that is, eliminate residual antibiotic and remain nutriment again and remove peculiar smell, thus should with good
Use prospect.
To achieve these goals, the present invention provides a kind of handling process of antibiotic bacterium dregs, wherein, institute
Stating handling process includes：In the presence of acidic materials, and in confined conditions, at 40-260 DEG C, will
Pending antibiotic bacterium dregs are degraded, and it is gentle that catabolite then is carried out into isolated solid formation mass flow
Phase material stream, and gaseous substance stream is post-processed.
By above-mentioned technical proposal, can be while the residual antibiotic in effectively degraded antibiotic bacterium dregs
Organic nutrient therein is effectively retained, for the innoxious use of bacteria residue provides good precondition.
Furthermore, technique of the invention can be prevented effectively from bacteria residue release difficult in processing procedure and after treatment
The problem of smelling, the bacteria residue odorless after treatment is environment-friendly.
Preferably, after the handling process is additionally included in degraded, it is depressured by the way of steam blasting, is made
Front and rear pressure differential at least 0.1MPa, more preferably 0.4-1.2MPa must be depressured.In this process
In, cell in bacteria residue can be made fully to crush, rupture, and make wherein each component, such as cellulose and
The abundant separate out of nutriment, such as protein, antibiosis is remained so as to be further ensured that in antibiotic bacterium dregs
Element is significantly degraded, and is effectively retained nutritional ingredient.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Brief description of the drawings
Accompanying drawing is, for providing a further understanding of the present invention, and to constitute the part of specification, with
Following specific embodiment is used to explain the present invention together, but is not construed as limiting the invention.
In accompanying drawing：
Fig. 1 is a kind of processing technological flow figure of the antibiotic bacterium dregs of specific embodiment of the invention.
Specific embodiment
Specific embodiment of the invention is described in detail below.It should be appreciated that this place is retouched
The specific embodiment stated is merely to illustrate and explain the present invention, and is not intended to limit the invention.
According to the present invention, the handling process of the antibiotic bacterium dregs includes：In the presence of acidic materials,
And in confined conditions, at 40-260 DEG C, pending antibiotic bacterium dregs are degraded, then will degraded
Product carries out the gentle phase material stream of isolated solid formation mass flow, and gaseous substance stream is post-processed.
Under preferable case, degradation temperature is more than or equal to 110 DEG C to being less than 200 DEG C, more preferably
120-190℃。
Solid formation mass flow of the present invention refers to solid-liquid of the antibiotic bacterium dregs by generation after degradation treatment
Mixture；Described gas gas-phase objects mass flow refers to gas mixing of the antibiotic bacterium dregs by generation after degradation treatment
Thing.
Handling process of the invention is used in the presence of acidic materials, and in confined conditions,
40-260 DEG C, pending antibiotic bacterium dregs are degraded, can effectively be reduced antibiotic concentration, improved
Solid phase protein content, removes bacteria residue peculiar smell, so as to reach hot acid degraded, harmless treatment and effective profit
With triple purposes of material.
According to the present invention, as long as effective degraded of the time guarantee antibiotic of the degraded and organic nutrition
Effective preservation of material, under preferable case, the time of the degraded is 0.05-180 minutes, enters one
Under step preferable case, when antibiotic bacterium dregs are processed using hot acid method, degradation time can be shorten to
3-80 minutes.
According to the present invention, the pressure of the degraded of the airtight condition can be 3KPa-5MPa, preferably
0.2-1.3MPa。
According to one of the invention preferred embodiment, in order to improve degradation efficiency, it is ensured that antibiotic bacterium
The abundant degraded and the retention of nutriment of slag, it is of the invention in the presence of acidic materials, and in closed bar
Under part, at 110-260 DEG C, more preferably greater than or equal to 110 DEG C are extremely less than 200 DEG C, further preferably
Degraded 0.1-180 minutes for 120-190 DEG C and under 3KPa-5MPa, preferably 0.2-1.3MPa,
After preferably 3-80 minutes, i.e. after degrading under these conditions, before catabolite is separated,
It is depressured by the way of steam blasting so that the pressure differential before and after step-down is at least 0.1MPa, preferably
0.4-1.2MPa.It is depressured by the way of steam blasting, moment is by the pressure state in closed environment from height
Pressure drop is to normal pressure or low pressure, so that the cell in antibiotic bacterium dregs is fully crushed, ruptured；And make wherein
Each component, such as cellulosic structure fully opened and nutriment, and such as protein is fully discharged,
So that the antibiotic of antibiotic bacterium dregs intraor extracellular is significantly degraded, and further realize hair of the invention
Improving eyesight.
According to the present invention, in the presence of acidic materials, and under degradation condition of the present invention, will treat
The treatment mode degraded of antibiotic bacterium dregs can be：Before degrading will pending antibiotic bacterium dregs
Contacted with acidic materials (for example, mixed pending antibiotic bacterium dregs with acidic materials before charging,
Or mix pending antibiotic bacterium dregs with acidic materials in charging), or will in degradation process
Pending antibiotic bacterium dregs are contacted with acidic materials, it is also possible to both before degrading by pending antibiotic
Bacteria residue is contacted with acidic materials, and again by pending antibiotic bacterium dregs and acidic materials in degradation process
Contact.Wherein, described contact is preferably mixing.
According to the present invention, in the presence of acidic materials, pending antibiotic bacterium dregs are degraded,
Under identical degradation time, degradation temperature can be reduced, or under identical degradation temperature, drop can be shortened
The solution time, while do not interfere with again, or even degradation efficiency can be improved.The present invention is to the acidic materials
Species and consumption are not particularly limited, and under preferable case, the consumption of acidic materials causes pending antibiotic
Acid concentration is in the range of 0.001M-5M in bacteria residue, preferably 0.005M-1M.
Further preferably, the acidic materials can also be able to be weak acid for strong acid, or strong acid with
The combination of weak acid, for example, the strong acid can be selected from the one kind in hydrochloric acid, sulfuric acid, phosphoric acid and pyrophosphoric acid
Or it is various, pKa (25 DEG C) value of the weak acid at least above -2, preferably at least above 0；For example,
Carboxylic acid can be selected from, such as in fumaric acid, lactic acid, citric acid, formic acid, acetic acid, ethanedioic acid, succinic acid
One or more.Additionally, the acidic materials can also be is presented acid amino acid, such as paddy ammonia
Acid and/or aspartic acid.
According to the present invention, the method that catabolite is carried out the gentle phase material stream of isolated solid formation mass flow
Can be carried out using method well known in the art, for example, by decompression, cooling, such as in cyclone separator
In, by the discharge of gaseous matter stream, and isolated solid formation mass flow.Meanwhile, the gaseous substance that will be discharged
Stream carries out conventional gas post processing well known in the art, to remove pernicious gas therein.Such as using life
The desulfurization of thing method, chemiadsorption etc. are removing the pernicious gases such as ammonia therein, hydrogen sulfide；For another example can be with
Using using the tail gas absorption for having peculiar smell or harmful components in the porous medias such as water or activated carbon absorption tail gas
Equipment, it would however also be possible to employ for the burning facility of incineration tail gas combustible component, when combustible component contains in tail gas
The fuel gas such as biogas, natural gas can be mixed when measuring relatively low carries out mixed burning.
According to the present invention, the water content of the pending antibiotic bacterium dregs can be 20-99 weight %, be
Can more efficiently treatment bacteria residue, improve treatment effeciency, it is specific as shown in figure 1, place of the invention
Science and engineering skill also includes：Before pending antibiotic bacterium dregs are degraded, will at least part of pending antibiotic
Bacteria residue carries out separation of solid and liquid, obtains pending antibiotic bacterium after the dehydration that moisture is 45-90 weight %
Slag and liquid phase substance stream, and by pending antibiotic bacterium dregs after dehydration individually degraded or with do not take off
The pending antibiotic bacterium dregs of water are degraded together.According to a specific embodiment of the invention, it is
Guarantee is effectively contacted with acidic materials, can by pending antibiotic bacterium dregs and acidic materials after dehydration
Directly individually degraded after contact, or can also be by pending antibiotic bacterium dregs and selectivity after dehydration
Ground contacted with acidic materials be not dehydrated pending antibiotic bacterium dregs together with optionally connect with acidic materials
Touch and degraded together.Wherein, " what is optionally contacted with acidic materials is not dehydrated pending antibiosis
Plain bacteria residue " and " optionally being contacted with acidic materials together " refer to this without dewater treatment
Antibiotic bacterium dregs can first be contacted before degraded with enough acidic materials, directly wait to locate with after dehydration afterwards
Managing antibiotic bacterium dregs to be degraded together, or be somebody's turn to do the antibiotic bacterium dregs without dewater treatment to degrade
Preceding elder generation contacts with the acidic materials of part, mix with pending antibiotic bacterium dregs after dehydration afterwards and with part
Acidic materials are contacted and degraded together, furthermore are somebody's turn to do the antibiotic bacterium dregs without dewater treatment and are treated after being dehydrated
Treatment antibiotic bacterium dregs be mixed contacted with acidic materials and together with degraded.
Further preferably, the technique also includes being dehydrated the isolated liquid phase substance stream to moisture containing
It is 55-85 weight % to measure, and individually carries out degraded and is preferably returned to together with pending antibiotic bacterium dregs after dehydration
Degraded.On the one hand, the dry substance concentration of pending antibiotic bacterium dregs is improved, it is possible to increase equipment
Treatment effeciency, is conducive to further reducing the residual concentration of antibiotic, improves solid phase protein content, separately
On the one hand, the liquid phase substance stream after separation of solid and liquid is further dehydrated, is such as returned after evaporation, concentration, with
Pending antibiotic bacterium dregs are degraded together after dehydration, it is possible to reduce steam consumption, and can be further
The a small amount of bacteria residue contained in liquid phase substance stream is carried out into degradation treatment together, treatment effect is improve, and
Also it is improved in continuous feed convenience and controllability.
Wherein, the method for the separation of solid and liquid can be used and carried out well known to a person skilled in the art method,
It is for instance possible to use the method such as plate-frame filtering.
According to the present invention, in order to further improve degradation effect, the degraded of the pending antibiotic bacterium dregs
It is preferred that carrying out under agitation.
According to the present invention, the present invention is preferably in air-liquid two-phase or gas, liquid, solid phase three-phase thermal response mistake
Degraded in journey, wherein, there is provided the thermal source of temperature includes steam and/or other heat carriers, mode of heating
Can directly be contacted with material and it be conducted heat, or heat carrier is by between container wall for heat carrier
Connect and give material heating, or above two mode of heating is combined and carried out.In the preferred case, there is provided temperature
Thermal source be steam, the steam can be saturated vapor and/or superheated steam, it is preferable that airtight condition
Vapour pressure more than or equal to synthermal lower vapor saturated vapor pressure.
The handling process of antibiotic bacterium dregs of the present invention can be carried out in equipment known in the art,
For example, can be in batch (-type) boiling vessel, such as conventional vertical digester, it is also possible in continuous steamer, such as
Carried out in conventional transverse tube type continuous steamer or tower continuous steamer.
According to the present invention, the species of the pending antibiotic bacterium dregs is not particularly limited, and can be existing
Various antibiotic bacterium dregs in technology, for example, from various following antibiotic bacterium dregs fermentations can be produced to produce
Raw bacteria residue and the bacteria residue material comprising the antibiotic, specifically, the antibiotic bacterium dregs can be selected
From containing beta-lactam class (such as cynnematin, penicillin), Tetracyclines (such as tetracycline, terramycin),
Macrolides (such as erythromycin) class, aminoglycoside (such as gentamicin, streptomysin), polypeptide
With the bacteria residue of one or more antibiotic in lincomycin class etc..
In the present invention, institute's finger pressure is absolute pressure.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited to above-mentioned reality
The detail in mode is applied, in range of the technology design of the invention, can be to technical side of the invention
Case carries out various simple variants, and these simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned specific embodiment,
In the case of reconcilable, can be combined by any suitable means, in order to avoid unnecessary
Repeat, the present invention is no longer separately illustrated to various possible combinations.
Additionally, can also be combined between a variety of implementation methods of the invention, as long as its
Without prejudice to thought of the invention, it should equally be considered as content disclosed in this invention.
Below will the present invention will be described in detail by embodiment.
In following examples, the pending antibiotic bacterium dregs are the bacteria residue for producing benzyl penicillin and erythromycin；
Wherein, the moisture of penicillin mushroom dregs is 81.6 weight %.Butt weight with penicillin mushroom dregs is as base
Standard, crude protein content is 40.7 weight %, and fiber content is 6.5 weight %, and crude fat content is 3.5
Weight %, the residual concentration of benzyl penicillin is 2.38 weight ‰ (2380ppm).Wherein, erythromycin bacterium
The moisture of slag is 90.1 weight %.On the basis of the butt weight of erythromycin bacterium slag, crude protein content
It is 34.1 weight %, fiber content is 2.6 weight %, and crude fat content is 8.9 weight %, erythromycin
Residual concentration is 1.71 weight ‰ (1710ppm).
Penicillin/erythromycin is remained in terms of ppm in catabolite in following embodiments and comparative example, 1ppm
Equivalent to 0.0001 weight %.
In following examples, the antibiotic crude protein content is determined by the method for kjeldahl determination and obtained,
By high performance liquid chromatography tandem mass spectrum method, (liquid chromatogram is Agilent to the content of antibiotic in bacteria residue
7890B, is equipped with binary gradient pump, vacuum on-line degassing machine, automatic sampler；Mass spectrograph is Agilent
Company 6540Q-TOF；Instrument controlling, data acquisition software and DAS are public using Agilent
The MassHnuter systems of department) method measures.
Chromatographic condition：HSS-T3 chromatographic columns, 100x2.1mm id., 1.8 μm of particle diameter, column temperature：40℃.
Mobile phase：A phases are that, containing the aqueous formic acid of 1 mass ‰, B phases are acetonitrile；Flow velocity 0.4ml/min.Sample introduction
Volume is 3 μ l.
Mass Spectrometry Conditions：Electron spray positive ion source (ESI+), voltage 3500V dries 300 DEG C of temperature degree,
Taper hole voltage 65V, 350 DEG C of sheath temperature degree dries gas and sheath throughput respectively 8L/min and 11L/min,
Atomization gas pressure 35psi, full scan pattern (50-1000amu).
In example 1 below -12 and comparative example 1-3, the operating temperature of batch (-type) vertical digester
40-300 DEG C, operating pressure 3KPa-10MPa；In embodiment 13-18 and comparative example 4, continous way
40-210 DEG C of boiling vessel operating temperature, operating pressure 3KPa-1.9MPa.
In following examples, gas processing device be using using activated carbon porous media absorb tail gas in have
The tail gas absorption equipment of peculiar smell or harmful components.
Embodiment 1
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
It is 0.01M that pending penicillin mushroom dregs are mixed into regulation to the acid concentration of penicillin mushroom dregs with citric acid,
And the penicillin mushroom dregs are placed in batch (-type) vertical digester, it is passed through saturated vapor so that batch (-type) steams
Saturated vapor pressure in boiler is 0.2MPa, in airtight condition, at 120 DEG C, under agitation degrade
15 minutes.Batch (-type) boiling vessel is carried out by the quick pressure releasing (pressure before and after pressure release using steam blasting mode
Difference is 0.1MPa), discharge gas is separated and sent into by cyclone separator and carry out in gas processing device
Post processing, and solid phase catabolite is isolated, measure is obtained, and Penicillin Residues are in catabolite
2.03ppm, crude protein content is 45.8 weight %.
Embodiment 2
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, acidic materials are acetic acid, drop
Solution temperature is 180 DEG C.Saturated vapor pressure during degraded in boiling vessel is 1.0MPa, the pressure before and after pressure release
Difference is 0.9MPa.Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content
It is 53.9 weight %.
Embodiment 3
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, degradation temperature is 150 DEG C.
Saturated vapor pressure during degraded in boiling vessel is 0.476MPa, and the pressure differential before and after pressure release is 0.37MPa.
Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content is 51.4 weight %.
Embodiment 4
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, acidic materials are acetic acid, drop
Solution temperature is 230 DEG C.Saturated vapor pressure during degraded in boiling vessel is 2.8MPa, the pressure before and after pressure release
Difference is 2.7MPa.Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content
It is 41.7 weight %.
Embodiment 5
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, acidic materials are acetic acid, drop
Solution temperature is 199 DEG C, and saturated vapor pressure during degraded in boiling vessel is 1.52MPa, the pressure before and after pressure release
Power difference is 1.45MPa.Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein contains
It is 52.1 weight % to measure.
Embodiment 6
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, degradation time is 80 minutes.
Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content is 49.3 weight %.
Embodiment 7
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, degradation time is 45 minutes.
Measure is obtained, and Penicillin Residues are 0.02ppm in catabolite, and crude protein content is 47.2 weight %.
Embodiment 8
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, used after the completion of degradation reaction
The mode of slow step-down carries out pressure release to normal pressure (moment pressure difference is both less than 0.1MPa).Measure is obtained, drop
Penicillin Residues are 2.75ppm in solution product, and crude protein content is 44.8 weight %.
Embodiment 9
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, institute is mixed with penicillin mushroom dregs
Acid is phosphoric acid.Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content
It is 47.8 weight %.
Embodiment 10
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, tune is mixed with penicillin mushroom dregs
The acid concentration for saving penicillin mushroom dregs is 0.82M.Measure is obtained, and Penicillin Residues are in catabolite
<0.01ppm, crude protein content is 47.2 weight %.
Embodiment 11
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 1 processes antibiotic bacterium dregs, unlike, handled antibiotic bacterium dregs
It is erythromycin bacterium slag.Measure is obtained, and erythromycin residual is 1.02ppm, crude protein content in catabolite
It is 36.4 weight %.
Embodiment 12
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 3 processes antibiotic bacterium dregs, unlike, handled antibiotic bacterium dregs
It is erythromycin bacterium slag.Measure is obtained, and erythromycin residual is in catabolite<0.01ppm, crude protein content
It is 40.8 weight %.
Embodiment 13
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
It is 0.01M that pending penicillin mushroom dregs are mixed into regulation to the acid concentration of penicillin mushroom dregs with citric acid,
And the penicillin mushroom dregs are placed in continuous transverse tube boiling vessel, it is passed through saturated vapor so that continuously stewing
Saturated vapor pressure in device is 0.2MPa, airtight condition, at 120 DEG C, degrade 15 under agitation
Minute.Then, continuous steamer is carried out by the quick pressure releasing (pressure before and after pressure release using steam blasting mode
Power difference is 0.1MPa), discharge gas is separated and sent into by cyclone separator and enter in gas processing device
Row post processing, and solid phase catabolite is isolated, measure is obtained, and Penicillin Residues are in catabolite
0.59ppm, crude protein content is 46.7 weight %.
Embodiment 14
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 13 processes penicillin mushroom dregs, unlike, degradation temperature is 160 DEG C.
Saturated vapor pressure during degraded in boiling vessel is 0.618MPa, and the pressure differential before and after pressure release is 0.517MPa.
Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content is 52.5 weight %.
Embodiment 15
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 13 processes penicillin mushroom dregs, unlike, degradation time is 100 points
Clock.Measure is obtained, and Penicillin Residues are in catabolite<0.01ppm, crude protein content is 49.8 weights
Amount %.
Embodiment 16
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 13 processes penicillin mushroom dregs, unlike, adopted after the completion of degradation reaction
Pressure release is carried out with the mode of slow step-down (moment pressure difference is both less than 0.1MPa).Measure is obtained, and degraded is produced
Penicillin Residues are 1.21ppm in thing, and crude protein content is 46.0 weight %.
Embodiment 17
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
It is penicillin mushroom dregs described in 81.6 weight % by moisture according to the technological process shown in accompanying drawing 1
Separation of solid and liquid is carried out by plate-frame filtering, solid formation mass flow and liquid phase that water content is 72.5 weight % is obtained
Material stream.During the isolated solid formation mass flow sent into continuously stewing device together with citric acid
(consumption of acid causes that the acid concentration of penicillin mushroom dregs is maintained at 0.01M), is passed through saturated vapor so that
Saturated vapor pressure in continuously stewing device maintains 0.476MPa, airtight condition, at 150 DEG C,
Degraded 15 minutes is maintained in continuously stewing device under agitation.Above-mentioned liquid phase substance stream is evaporated,
It is concentrated into water content for 72 weight % and this is continuous through pervaporation, the liquid phase substance stream being concentrated to give
It is back in continuously stewing device to be degraded together with pending penicillin mushroom dregs after dehydration and (if desired mends
Addition acidic materials are filled, then sour consumption causes that the acid concentration of penicillin mushroom dregs remains at 0.01M).
After the completion of degraded, continuous steamer is carried out into quick pressure releasing by catabolite using steam blasting mode and (is let out
Pressure differential before and after pressure is 0.375MPa) and draw off, discharge gas is separated simultaneously by cyclone separator
Post-processed in feeding tail gas treatment device, measure is obtained, and Penicillin Residues are in catabolite
<0.01ppm, crude protein content is 51.8 weight %.
Embodiment 18
This example demonstrates that the handling process and its result of the antibiotic bacterium dregs that the present invention is provided.
Method according to embodiment 17 processes antibiotic bacterium dregs, unlike, handled antibiotic bacterium
Slag is erythromycin bacterium slag.Measure is obtained, and erythromycin residual is in catabolite<0.01ppm, crude protein contains
It is 41.3 weight % to measure.
Comparative example 1
This comparative example is used for the handling process and its result of the antibiotic bacterium dregs for illustrating prior art.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, it is added without acid, degradation temperature
It is 300 DEG C.Measure is obtained, and Penicillin Residues are in catabolite<0.01 weight %, crude protein content is
14.3 weight %.
Comparative example 2
This comparative example is used for the handling process and its result of the antibiotic bacterium dregs for illustrating prior art.
Method according to embodiment 1 processes penicillin mushroom dregs, unlike, it is added without acid, degradation temperature
It it is 300 DEG C, degradation time is 120 minutes.Measure is obtained, and Penicillin Residues are in catabolite
<0.01ppm, crude protein content is 9.3 weight %.
Comparative example 3
This comparative example is used for the handling process and its result of the antibiotic bacterium dregs for illustrating prior art.
Method according to embodiment 1 processes erythromycin bacterium slag, unlike, degradation temperature is 300 DEG C.
Measure is obtained, and erythromycin residual is in catabolite<0.01ppm, crude protein content is 7.5 weight %.
Comparative example 4
This comparative example is used for the handling process and its result of the antibiotic bacterium dregs for illustrating prior art.
Method according to embodiment 13 processes penicillin mushroom dregs, unlike, degradation temperature is 35 DEG C,
Degradation time is 120 minutes.Measure is obtained, and Penicillin Residues are 2210ppm, thick egg in catabolite
Bai Hanliang is 40.9 weight %.
Claims (14)
1. a kind of handling process of antibiotic bacterium dregs, it is characterised in that the handling process includes：
In the presence of acidic materials, and in confined conditions, at 40-260 DEG C, pending antibiotic bacterium dregs are entered
Row degraded, then carries out the gentle phase material stream of isolated solid formation mass flow by catabolite, and by gas phase
Material stream is post-processed.
2. the handling process of antibiotic bacterium dregs according to claim 1, wherein, the pressure of degraded
It is 3KPa-5MPa, preferably 0.2-1.3MPa, the time of degraded is 0.05-180 minutes, preferably
3-80 minutes.
3. the handling process of antibiotic bacterium dregs according to claim 2, wherein, degradation temperature is
More than or equal to 110 DEG C to less than 200 DEG C, more preferably 120-190 DEG C.
4. the handling process of antibiotic bacterium dregs according to claim 3, wherein, place's science and engineering
Skill also includes：
After degradation, before catabolite is separated, it is depressured by the way of steam blasting so that
Pressure differential before and after step-down is at least 0.1MPa, preferably 0.4-1.2MPa.
5. the handling process of the antibiotic bacterium dregs according to any one in claim 1-3, wherein,
In the presence of acidic materials, and in confined conditions, at 40-260 DEG C, by pending antibiotic bacterium dregs
The method degraded includes：Before pending antibiotic bacterium dregs are degraded, by pending antibiosis
Plain bacteria residue is contacted and/or in degradation process with acidic materials, by pending antibiotic bacterium dregs and acidic materials
Contact.
6. the handling process of antibiotic bacterium dregs according to claim 5, wherein, acidic materials
Acid concentration is 0.001M-5M during consumption makes pending antibiotic bacterium dregs.
7. the handling process of antibiotic bacterium dregs according to claim 6, wherein, acidic materials
Acid concentration is 0.005M-1M during consumption makes pending antibiotic bacterium dregs.
8. the handling process of the antibiotic bacterium dregs according to claim 1,6 or 7, wherein, it is described
Acidic materials be selected from sulfuric acid, hydrochloric acid, phosphoric acid, pyrophosphoric acid, fumaric acid, lactic acid, citric acid, malic acid,
One or more in formic acid, acetic acid, ethanedioic acid, succinic acid and acidic amino acid, it is preferable that the acid
Acidic amino acid is glutamic acid and/or aspartic acid.
9. the handling process of antibiotic bacterium dregs according to claim 5, wherein, place's science and engineering
Skill also includes：Before pending antibiotic bacterium dregs are degraded, will at least part of pending antibiotic
Bacteria residue carries out separation of solid and liquid, obtains pending antibiotic bacterium after the dehydration that moisture is 45-90 weight %
Slag and liquid phase substance stream, and pending antibiotic bacterium dregs after dehydration are contacted and dropped with acidic materials
Solution, or pending antibiotic bacterium dregs after dehydration are treated with not being dehydrated of optionally being contacted with acidic materials
Treatment antibiotic bacterium dregs optionally contact with acidic materials together and together with degraded.
10. the handling process of antibiotic bacterium dregs according to claim 9, wherein, place's science and engineering
Skill also includes：It is 55-85 weight % that the isolated liquid phase substance stream is dehydrated to moisture,
And return is degraded together with pending antibiotic bacterium dregs after dehydration.
The handling process of 11. antibiotic bacterium dregs according to any one in claim 1-4, wherein,
The degraded is carried out under agitation.
The handling process of 12. antibiotic bacterium dregs according to claim 1 or 3, wherein, there is provided drop
Solve temperature thermal source be saturated vapor and/or superheated steam, and cause airtight condition vapour pressure be more than or
Equal to the saturated vapor pressure of synthermal lower vapor.
Place's science and engineering of 13. antibiotic bacterium dregs according to any one in claim 1-4,9 and 10
Skill, wherein, the water content of the pending antibiotic bacterium dregs is 20-99 weight %.
Place's science and engineering of 14. antibiotic bacterium dregs according to any one in claim 1-4,9 and 10
Skill, wherein, antibiotic bacterium dregs are selected from and contain beta-lactam class, Tetracyclines, macrolides, amino
One or more bacteria residue in glucosides, polypeptide and lincomycin series antibiotics.
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