CN109013641A - A kind of method of antibiotic bacterium dregs removing toxic substances - Google Patents
A kind of method of antibiotic bacterium dregs removing toxic substances Download PDFInfo
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- CN109013641A CN109013641A CN201810757584.5A CN201810757584A CN109013641A CN 109013641 A CN109013641 A CN 109013641A CN 201810757584 A CN201810757584 A CN 201810757584A CN 109013641 A CN109013641 A CN 109013641A
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- bacterium dregs
- antibiotic bacterium
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- 241000894006 Bacteria Species 0.000 title claims abstract description 106
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 34
- 231100000614 poison Toxicity 0.000 title claims abstract description 22
- 239000003440 toxic substance Substances 0.000 title claims abstract description 21
- 239000000126 substance Substances 0.000 claims abstract description 26
- 238000007701 flash-distillation Methods 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 21
- 238000001027 hydrothermal synthesis Methods 0.000 claims abstract description 12
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000012545 processing Methods 0.000 claims abstract description 7
- 238000007689 inspection Methods 0.000 claims abstract description 5
- 238000001514 detection method Methods 0.000 claims description 18
- 231100000331 toxic Toxicity 0.000 claims description 7
- 230000002588 toxic effect Effects 0.000 claims description 7
- 239000002647 aminoglycoside antibiotic agent Substances 0.000 claims description 6
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 5
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 5
- 229940124586 β-lactam antibiotics Drugs 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 3
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 229940072172 tetracycline antibiotic Drugs 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 239000002699 waste material Substances 0.000 abstract description 5
- 239000002028 Biomass Substances 0.000 abstract description 3
- 238000004064 recycling Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 description 10
- 239000003242 anti bacterial agent Substances 0.000 description 9
- 229940088710 antibiotic agent Drugs 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 4
- 229930186147 Cephalosporin Natural products 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 229940124587 cephalosporin Drugs 0.000 description 3
- 150000001780 cephalosporins Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 229930182566 Gentamicin Natural products 0.000 description 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 2
- OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- KIPLYOUQVMMOHB-MXWBXKMOSA-L [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O Chemical compound [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C([O-])[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c1c(O)cccc1[C@@]3(C)O KIPLYOUQVMMOHB-MXWBXKMOSA-L 0.000 description 2
- -1 amino alditol Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229960002518 gentamicin Drugs 0.000 description 2
- 239000002920 hazardous waste Substances 0.000 description 2
- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 2
- 229960005287 lincomycin Drugs 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 239000011819 refractory material Substances 0.000 description 2
- 239000010801 sewage sludge Substances 0.000 description 2
- 238000010025 steaming Methods 0.000 description 2
- 229940063650 terramycin Drugs 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 108010001478 Bacitracin Proteins 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000187747 Streptomyces Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 229930184125 bacitracin Natural products 0.000 description 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007665 chronic toxicity Effects 0.000 description 1
- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 238000013139 quantization Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE
- B09B5/00—Operations not covered by a single other subclass or by a single other group in this subclass
Abstract
The invention belongs to biomass waste process fields, disclose a kind of method of antibiotic bacterium dregs removing toxic substances, which comprises pulp processing: the antibiotic bacterium dregs of quasi- processing and water being mixed, are stirred evenly, so that the concentration of mixed material is 5~10%；Hydro-thermal process: the material that pulp is disposed, being passed through temperature is 200~230 DEG C, pressure in the saturated vapor of 1.6~2.8MPa, and temperature of charge is caused to rise to 160~200 DEG C, and 30~120min of residence time；Flash distillation process: the material that hydro-thermal process is finished carries out pressure release, and temperature of charge is caused to be reduced to 90~100 DEG C；It examines: the material after flash distillation process is subjected to chemical titer inspection.Chemical titer in antibiotic bacterium dregs can be reduced to zero by method of the invention, that is, realize the removing toxic substances of antibiotic bacterium dregs, and the removing toxic substances of antibiotic bacterium dregs is that the minimizing of antibiotic bacterium dregs and recycling provide the foundation.
Description
Technical field
The invention belongs to biomass wastes to handle disposal technology field, and in particular to a kind of side of antibiotic bacterium dregs removing toxic substances
Method.
Background technique
Antibiotic bacterium dregs are the Main By products during antibiotics production, and essence is during producing antibiotics production
Culture medium waste, be hazardous waste as defined in " National Hazard waste register ".It is certain due to being remained in antibiotic waste water, bacteria residue
Antibiotic enters meeting in soil and water body and generates inhibiting effect to the growth of certain animals and plants, influences biology composition thus broken
The intrinsic ecological balance of bad environment, residual antibiotic eventually passes through food chain and is transmitted to human body in environment, reaches a certain concentration
The problems such as generating drug resistance afterwards, causes high risks to human health.So the removing toxic substances of antibiotic bacterium dregs, is at antibiotic bacterium dregs
Manage the most critical factor of disposition.
Therefore, the residues of antibiotics in antibiotic bacterium dregs how is effectively killed, realizes that antibiotic bacterium dregs chemical titer is zero
It becomes for a technical problem to be solved urgently.
Summary of the invention
The purpose of the present invention is how to kill the residues of antibiotics in antibiotic bacterium dregs, i.e. realization antibiotic bacterium dreg chemistry is imitated
Valence is zero.
The technical solution adopted in the present invention is as follows:
A kind of method of antibiotic bacterium dregs removing toxic substances, which comprises pulp reaction, pyrohydrolysis reaction, flash distillation, detection four
A processing step:
Step S1, antibiotic bacterium dregs are pumped into pulp tank, material is adjusted into concentration to 5-10% containing solid in pulp tank
Rate (boiler is filled the water to pulp tank), and stir evenly；
Step S2, the antibiotic bacterium dregs in pulp tank are pumped into hydro-thermal tank, be passed through saturated vapor (200~230 DEG C,
1.6MPa~2.3MPa), it is heated to 160 DEG C~200 DEG C, preferably 180 DEG C, residence time 30-120min.Antibiotic bacterium dregs
In residues of antibiotics be destroyed in the hydro-thermal tank of high temperature and pressure；
Step S3, flash tank, antibiotic bacterium in pressure leak process are inputted after 160 DEG C~200 DEG C of high temperature bacteria residue hydro-thermal process
Eucaryotic cell structure in slag is further destroyed.
Step S4, near 90-100 DEG C of the bacteria residue temperature after flash distillation, is discharged into bacteria residue storage bin, carries out toxicization to bacteria residue
Learn detection.
Compared with prior art, the method for a kind of antibiotic bacterium dregs removing toxic substances provided by the present invention, can be by antibiotic bacterium dregs
In chemical titer be reduced to zero, that is, realize the removing toxic substances of antibiotic bacterium dregs, the removing toxic substances of antibiotic bacterium dregs is subtracting for antibiotic bacterium dregs
Quantization and recycling provide the foundation.
Detailed description of the invention
Fig. 1 is the working principle diagram of the method for the removing toxic substances of antibiotic bacterium dregs described in the embodiment of the present invention.
Specific embodiment
Below in conjunction with attached drawing, invention is further described in detail, but not as a limitation of the invention.
Shown in referring to Fig.1, a kind of method of antibiotic bacterium dregs removing toxic substances disclosed in the embodiment of the present invention, including walk as follows
It is rapid:
Step S1, pulp is handled: the antibiotic bacterium dregs of quasi- processing and water are mixed, are stirred evenly, so that mixed material
Concentration is 5~10%, forms flow morphology；
Wherein, in step sl, pulp processing carries out in pulp tank, and antibiotic bacterium dregs are led to by entering from raw material cabin
It crosses conveyer belt and bacteria residue is delivered into pulp tank from pulp tank top or side surface upper part, the pulp tank also has connection hot water
The water inlet of case, the water inlet also are located at pulp tank top or side surface upper part, when bacteria residue enters, open simultaneously boiler
Valve, convey hot water into pulp tank, mixed with bacteria residue, and be stirred uniformly by blender, so that solid content
Between 5~10% namely moisture content is between 90~95%, so that flow morphology of the material shape at pulp, convenient for conveying.Institute
It states and is additionally provided with pressure sensor, temperature sensor and liquid level sensor in pulp tank, be respectively used to press pulp material
Power detection, temperature detection and level sensing.
Step S2, hydro-thermal process: the material that pulp is disposed is passed through temperature and exists in 200 DEG C~230 DEG C, pressure
Saturated vapor between 1.6MPa~2.8MPa causes temperature of charge to rise to 160~180 DEG C, and the residence time 30~
120min；By hydro-thermal process, the residues of antibiotics in antibiotic bacterium dregs is destroyed in the hydro-thermal tank of high temperature and pressure.
Wherein, in step s 2, hydro-thermal process carries out in hydro-thermal tank, and pulp pot bottom is discharge gate, hydro-thermal tank top
Or side surface upper part is feed inlet, the material after pulp enters inside hydro-thermal tank from hydro-thermal tank top.In hydro-thermal tank, it will lead to
The saturated vapor for entering high-temperature, high pressure, heats material, and steam is squeezed into from the bottom of hydro-thermal tank, thus in tank
Bacteria residue is sufficiently mixed.For saturated vapor, temperature and pressure is one-to-one, such as when the vapor (steam) temperature being passed through is 200 DEG C
When, pressure value is preferable in 1.6MPa, and steam can not be pressed into tank by too low temperature and pressure, while hydrothermal temperature deficiency can be led
Cause bacteria residue pyrohydrolysis underaction in hydro-thermal tank, although and excessively high vapor (steam) temperature and pressure to pyrohydrolysis react it is more advantageous,
But requirements at the higher level, equipment cost, which can greatly improve, to be proposed to equipment itself.In the embodiment of the present invention, the saturated-steam temperature that is passed through
In 200 DEG C~230 DEG C, pressure between 1.6MPa~2.8MPa, the temperature of saturated vapor no more than 230 DEG C, pressure it is unsuitable
More than 2.8MPa, can so be played under the premise of guaranteeing equipment cost it is good hydrothermal, the saturated vapor that is passed through with
Bacteria residue mixing, when material being caused to be heated to 160~230 DEG C, in the hydrothermal system using saturated vapor as heat transfer medium, reaction
Temperature is higher, and pyrohydrolysis reaction effect is better, but crosses the saturated vapor that high reaction temperature generally requires higher temperature and pressure, this
The design, construction and operation of hydro-thermal tank itself made higher requirement, especially valve, cost can greatly improve, therefore
It is highly preferred that the present invention can be maintained in material when being heated to 180 DEG C.Reaction stays for some time, 30~120min compared with
Good, the different biological natures according to belonging to bacteria residue, reaction time can slightly have difference, such as polypeptide antibiotics bacterium
Slag, aminoglycoside antibiotics bacteria residue, macrolide antibiotic bacterium dregs, beta-lactam antibiotic bacteria residue, what hydro-thermal stopped
Time is preferably 55~65min, and 60min is best.For aminoglycoside antibiotics bacteria residue, hydro-thermal residence time is 25~
35min, 30min are best.For tetracycline antibiotics bacteria residue, hydro-thermal residence time is 80~100min, and 90min is most
It is good, it so can guarantee and realize good pyrolysis effect under the premise of reducing energy consumption.Pressure sensor is provided in the hydro-thermal tank
And temperature sensor, with the pressure and temperature of real-time detection hydro-thermal reaction, to carry out pressure and temperature adjusting.Due to absolutely mostly
Number antibiotic non-refractories, will generally occur open loop at 100 DEG C or so, and the Fourth Ring class of better heat stability and amino alditol
Class antibiotic also can occur below open loop at 160 DEG C.Most antibiotic non-refractories, will generally send out at 100 DEG C or so
Raw open loop, the Fourth Ring class and amino sugar aldehydes antibiotic of better heat stability also can occur below open loop at 160 DEG C.Hydrothermal technique
Using saturated vapor as reaction medium, the eucaryotic cell structure in biomass waste is destroyed, effective sterilization is realized, compares electric heating side
Formula, so that heating is more evenly, heating effect is good.In the present invention, hydrothermal temperature is preferably set to 180 DEG C, can make substantially
It obtains whole antibiotic and open loop occurs, and pass through the reaction time of setting, it being capable of thorough open loop.
Step S3, flash distillation process: the material that hydro-thermal process is finished carries out pressure release, cause temperature of charge be reduced to 90~
100℃；Flash tank, the eucaryotic cell structure quilt in pressure leak process in antibiotic bacterium dregs are inputted after 180 DEG C of high temperature bacteria residue hydro-thermal process
Further destroy.
Wherein, in step s3, the flash distillation process carries out in flash tank, and the flash tank feed inlet is located at tank top
Or side surface upper part.High pressure-temperature fluid makes the reduction of its boiling point by decompression, and into flash tank, at this moment, fluid temperature (F.T.) is higher than should
Boiling point under pressure, fluid boiling vaporization rapidly in flash tank, and carry out two-phase laminated flow.The flash drum overhead, which is connected with, lets out
Pressure valve opens valve, carries out pressure releasing.Pressure sensor and temperature sensor are additionally provided in the flash tank, after flash distillation
Temperature be set as 100~110 DEG C.
Flash distillation is a kind of mode of fast cooling, while can also further realize breaking-wall cell and recovery section steam,
Temperature is generally only capable of being down to 90 DEG C or so after single stage flash, and multistage flash distillation is able to achieve fast cooling while recycling more steaminess, therefore
A preferred mode of the invention is that the flash distillation process is carried out using Multi-stage flash steaming pot.
Step S4: the material after flash distillation process is subjected to toxic inspection.
In step s 4, near 90-100 DEG C of the bacteria residue temperature after flash distillation is discharged into the collection of bacteria residue storage bin, carries out bacteria residue
It is toxic.
In the present embodiment, toxic detection includes a variety of evaluation methods.
Mode one, chemical titer are examined, and the measurement of chemical titer can extract measurement by titer of antibodies analyzer.
The chemical titer that antibiotic is measured by high performance liquid chromatography is most efficient, the sensitive method of current detection antibiotic remnants.
Mode two, bio-toxicity evaluation means, bio-toxicity evaluation means can reflect antibiotic bacterium dregs to biological subject
Combined influence, and detection method it is sensitive efficiently, be important Testing index one of of the antibiotic bacterium dregs as hazardous waste.It is examining
When examining the bio-toxicity of antibiotic bacterium dregs, most commonly development acute toxicity and chronic toxicity is evaluated, and generallys use EC50 value
Carry out toxicity size.It includes photobacteria, fish, Magna etc., chronic poison that wide biological subject is applied in acute toxic test
Property test in using more biological subject include algae, fish, mouse, rabbit etc..
Mode three, antibiotic bacterium dregs contain drug-fast bacteria and drug resistant gene, while residues of antibiotics therein and its intermediary
Mass-energy induces the microorganism around receptor to generate drug resistant gene, so needing to measure by real-time fluorescence quantitative PCR and high pass
The means such as sequence carry out system detection to the drug resistant gene of microorganism in antibiotic bacterium dregs and its treatment process and receptor.
And completely and accurately judged for the toxic progress to material, it is preferred to use above three mode carries out simultaneously
It judges.
Embodiment one
Bacitracin belongs to polypeptide antibiotics, and bacteria residue moisture content is 90.5%, and bacteria residue chemical titer is 92u/mL.By bar
Bacterium peptide bacteria residue is pumped to pulp tank after mixing evenly, subsequently into hydro-thermal tank, hydro-thermal 60min under the conditions of 180 DEG C, by dodging
Detection is collected after steaming, measuring chemical titer is 0.
Embodiment two
For Streptomyces in aminoglycoside antibiotics, bacteria residue moisture content is 94.7%, and bacteria residue chemical titer is 1080u/
mL.Streptomysin bacteria residue is pumped to pulp tank after mixing evenly, subsequently into hydro-thermal tank, hydro-thermal under the conditions of 180 DEG C
60min collects detection after flash distillation, and measuring chemical titer is 0.
Embodiment three
Gentamicin belongs to aminoglycoside antibiotics, and bacteria residue moisture content is 96.9%, and bacteria residue chemical titer is 31u/
mL.Gentamicin bacteria residue is pumped to pulp tank after mixing evenly, subsequently into hydro-thermal tank, hydro-thermal under the conditions of 180 DEG C
30min collects detection after flash distillation, and measuring chemical titer is 0.
Example IV
Lincomycin belongs to macrolide antibiotics, and bacteria residue moisture content is 83.4%, and bacteria residue chemical titer is 256u/
mL.Lincomycin fungi residues are pumped to pulp tank after mixing evenly, bacteria residue are diluted to 10% solid content in pulp tank, then
Into in hydro-thermal tank, hydro-thermal 60min under the conditions of 180 DEG C collects detection after flash distillation, and measuring chemical titer is 0.
Embodiment five
Penicillin belongs to beta-lactam antibiotic, and bacteria residue moisture content is 79.6%, and bacteria residue chemical titer is 128u/
mL.Penicillin mushroom dregs are pumped to pulp tank after mixing evenly, bacteria residue is diluted to 10% solid content in pulp tank, then into
Enter in hydro-thermal tank, hydro-thermal 60min under the conditions of 180 DEG C, detection is collected after flash distillation, measuring chemical titer is 0.
Embodiment six
Cephalosporin belongs to beta-lactam antibiotic, and bacteria residue moisture content is 92.6%, and bacteria residue chemical titer is
133u/mL.Cephalosporin bacteria residue is pumped to pulp tank after mixing evenly, subsequently into hydro-thermal tank, under the conditions of 180 DEG C
Hydro-thermal 60min collects detection after flash distillation, and measuring chemical titer is 0.
Embodiment seven
Ospeneff belongs to beta-lactam antibiotic, and bacteria residue moisture content is 81.9%, and bacteria residue chemical titer is
142u/mL.Ospeneff bacteria residue is pumped to pulp tank after mixing evenly, bacteria residue is diluted to 10% containing solid in pulp tank
Rate, subsequently into hydro-thermal tank, hydro-thermal 60min under the conditions of 180 DEG C collects detection after flash distillation, and measuring chemical titer is
0。
Embodiment eight
Terramycin belongs to tetracycline antibiotics, and bacteria residue moisture content is 90.8%, and bacteria residue chemical titer is 1590u/mL.It will
Terramycin bacteria residue is pumped to pulp tank after mixing evenly, and subsequently into hydro-thermal tank, hydro-thermal 90min under the conditions of 180 DEG C passes through
Detection is collected after flash distillation, measuring chemical titer is 0.
Embodiment nine
Sewage sludge results from the sewage treatment plant of antibiotics production enterprise, and antibiotics production corporate boss will produce bacillus
Peptide, streptomysin and cephalosporin, moisture percentage in sewage sludge 89.1%, the chemical titer of three kinds of antibiotic are respectively 6,8 and 6.It will be dirty
Mud is pumped to pulp tank after mixing evenly, and bacteria residue is diluted to 10% solid content in pulp tank, subsequently into hydro-thermal tank,
Hydro-thermal 60min under the conditions of 180 DEG C collects detection after flash distillation, and the chemical titer for measuring three kinds of antibiotic is 0.
Several preferred embodiments of the invention have shown and described in above description, but as previously described, it should be understood that the present invention
Be not limited to forms disclosed herein, should not be regarded as an exclusion of other examples, and can be used for various other combinations,
Modification and environment, and above-mentioned guidance or the technology or knowledge of related fields can be passed through within that scope of the inventive concept describe herein
It is modified.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of the present invention, then it all should be in this hair
In the protection scope of bright appended claims.
Claims (8)
1. a kind of method of antibiotic bacterium dregs removing toxic substances, which is characterized in that the described method includes:
Step S1, pulp is handled: the antibiotic bacterium dregs of quasi- processing and water being mixed, are stirred evenly, so that the concentration of mixed material
It is 5~10%；
Step S2, hydro-thermal process: the material that pulp is disposed, be passed through temperature be 200~230 DEG C, pressure 1.6~
Saturated vapor between 2.8MPa causes temperature of charge to rise to 160~200 DEG C, and 30~120min of residence time；
Step S3, flash distillation process: the material that hydro-thermal process is finished carries out pressure release, and temperature of charge is caused to be reduced to 90~110 DEG C；
Step S4, it examines: the material after flash distillation process is subjected to toxic inspection.
2. the method for antibiotic bacterium dregs removing toxic substances as described in claim 1, which is characterized in that the pulp processing is in pulp tank
It carries out, the hydro-thermal process carries out in hydro-thermal tank, and the flash distillation process carries out in flash tank, and the chemical titer is examined
Bacteria residue storage bin carries out, wherein the pulp tank, hydro-thermal tank, flash tank, bacteria residue storage bin are sequentially connected, and the pulp tank is also
Connect boiler.
3. the method for antibiotic bacterium dregs removing toxic substances as claimed in claim 2, which is characterized in that be additionally provided with pressure in the pulp tank
Force snesor, temperature sensor and liquid level sensor are provided with pressure sensor and temperature in the hydro-thermal tank and flash tank
Sensor.
4. the method for antibiotic bacterium dregs removing toxic substances as described in claim 1, which is characterized in that toxic the including: of inspection
Learn potency inspection, bio-toxicity evaluation, drug-fast bacteria and drug resistant gene detection.
5. the method for antibiotic bacterium dregs as described in claim 1 removing toxic substances, which is characterized in that for polypeptide antibiotics bacteria residue,
Aminoglycoside antibiotics bacteria residue, macrolide antibiotic bacterium dregs, beta-lactam antibiotic bacteria residue, hydro-thermal residence time
For 60min.
6. the method for antibiotic bacterium dregs removing toxic substances as described in claim 1, which is characterized in that be directed to aminoglycoside antibiotics bacterium
Slag, hydro-thermal residence time are 30min.
7. the method for antibiotic bacterium dregs removing toxic substances as described in claim 1, which is characterized in that it is directed to tetracycline antibiotics bacteria residue,
Hydro-thermal residence time is 90min.
8. the method for antibiotic bacterium dregs removing toxic substances as claimed in claim 2, which is characterized in that the bacteria residue for entering the pulp tank enters
Mouth and hot water inlet are respectively positioned on the pulp tank top or side surface upper part, and the saturated vapor is passed through from the bottom of the hydro-thermal tank
Hybrid Heating is carried out with material.
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