CN106749231B - 萘啶化合物和药物组合物及它们的应用 - Google Patents
萘啶化合物和药物组合物及它们的应用 Download PDFInfo
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- CN106749231B CN106749231B CN201610880102.6A CN201610880102A CN106749231B CN 106749231 B CN106749231 B CN 106749231B CN 201610880102 A CN201610880102 A CN 201610880102A CN 106749231 B CN106749231 B CN 106749231B
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- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (5)
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CN201610880102.6A CN106749231B (zh) | 2016-10-09 | 2016-10-09 | 萘啶化合物和药物组合物及它们的应用 |
EP16918185.6A EP3421038B1 (en) | 2016-10-09 | 2016-11-08 | Naphthyridine compound, pharmaceutical composition and use thereof |
JP2019540476A JP6862563B2 (ja) | 2016-10-09 | 2016-11-08 | ナフチリジン化合物、薬物組成物およびそれらの使用 |
PT169181856T PT3421038T (pt) | 2016-10-09 | 2016-11-08 | Compostos de naftiridina, combinações médicas e sua utilização |
PCT/CN2016/105012 WO2018064852A1 (zh) | 2016-10-09 | 2016-11-08 | 萘啶化合物和药物组合物及它们的应用 |
ES16918185T ES2784525T3 (es) | 2016-10-09 | 2016-11-08 | Compuestos de naftiridina, combinaciones médicas y uso de las mismas |
AU2016425880A AU2016425880B2 (en) | 2016-10-09 | 2016-11-08 | Naphthyridine compound, pharmaceutical composition and use thereof |
PL16918185T PL3421038T3 (pl) | 2016-10-09 | 2016-11-08 | Związek naftyrydyny, kompozycja farmaceutyczna i ich zastosowanie |
US15/402,768 US9938274B1 (en) | 2016-10-09 | 2017-01-10 | Naphthyridine compounds, medical combinations and use thereof |
JP2021005294A JP7085032B2 (ja) | 2016-10-09 | 2021-01-15 | ナフチリジン化合物、薬物組成物およびそれらの応用 |
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EP (1) | EP3421038B1 (zh) |
JP (2) | JP6862563B2 (zh) |
CN (1) | CN106749231B (zh) |
AU (1) | AU2016425880B2 (zh) |
ES (1) | ES2784525T3 (zh) |
PL (1) | PL3421038T3 (zh) |
PT (1) | PT3421038T (zh) |
WO (1) | WO2018064852A1 (zh) |
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IL302209B2 (en) | 2015-11-02 | 2024-06-01 | Blueprint Medicines Corp | RET inhibitors |
CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての置換ピロロ[2,3-d]ピリミジン化合物 |
SI3773589T1 (sl) | 2018-04-03 | 2024-03-29 | Blueprint Medicines Corporation | Inhibitor RET za uporabo pri zdravljenju raka, ki ima RET spremembo |
CN110862397A (zh) * | 2018-08-27 | 2020-03-06 | 北京赛特明强医药科技有限公司 | 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用 |
CN111961045A (zh) * | 2020-08-07 | 2020-11-20 | 南京纳丁菲医药科技有限公司 | 1,6-萘啶-4(1h)-酮化合物的合成方法 |
CN113520999B (zh) * | 2021-07-30 | 2022-08-09 | 石家庄四药有限公司 | 含萘啶类化合物的口服液及其制备方法 |
CN113633623A (zh) * | 2021-08-25 | 2021-11-12 | 石家庄四药有限公司 | 一种含萘啶类化合物的胶囊及其制备方法 |
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WO2007095187A2 (en) * | 2006-02-13 | 2007-08-23 | Trustees Of Boston University | Compositions and methods for antibiotic potentiation and drug discovery |
WO2013097753A1 (zh) * | 2011-12-31 | 2013-07-04 | 江苏先声药业有限公司 | 一类稠杂环衍生物及其应用 |
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US6809097B1 (en) | 1996-09-25 | 2004-10-26 | Zeneca Limited | Quinoline derivatives inhibiting the effect of growth factors such as VEGF |
AU2012223639B2 (en) * | 2011-02-28 | 2015-03-19 | Sunshine Lake Pharma Co., Ltd. | Substituted quinoline compounds and methods of use |
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2016
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- 2016-11-08 EP EP16918185.6A patent/EP3421038B1/en active Active
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WO2007095187A2 (en) * | 2006-02-13 | 2007-08-23 | Trustees Of Boston University | Compositions and methods for antibiotic potentiation and drug discovery |
WO2013097753A1 (zh) * | 2011-12-31 | 2013-07-04 | 江苏先声药业有限公司 | 一类稠杂环衍生物及其应用 |
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PL3421038T3 (pl) | 2020-06-29 |
JP6862563B2 (ja) | 2021-04-21 |
US20180099962A1 (en) | 2018-04-12 |
AU2016425880A1 (en) | 2019-05-30 |
EP3421038A1 (en) | 2019-01-02 |
JP7085032B2 (ja) | 2022-06-15 |
CN106749231A (zh) | 2017-05-31 |
AU2016425880B2 (en) | 2020-09-17 |
US9938274B1 (en) | 2018-04-10 |
ES2784525T3 (es) | 2020-09-28 |
EP3421038A4 (en) | 2019-03-20 |
WO2018064852A1 (zh) | 2018-04-12 |
JP2019534323A (ja) | 2019-11-28 |
PT3421038T (pt) | 2020-04-22 |
EP3421038B1 (en) | 2020-01-15 |
JP2021054871A (ja) | 2021-04-08 |
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