CN106729589A - Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine - Google Patents
Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation and preparation method for treating transmissible gastroenteritis of swine, belong to Chinese herbal medicine preparation technology field.The Chinese medicine preparation is made by the raw material of following parts by weight：Bitter dish, carpet bugle, mountain lettuce, baked ginger, iron railing, six songs, Sargent gloryvine, Chinese lobelia, Herba Ixeritis polycephalae, Thlaspis, southern Guangdong birthwort, osbeckia, catchweed bedstraw herb, Chinese Fevervine Herb, manyleaf meadowure rhizome and root, polygonum flaccidum, Glabrous Sarcandra Herb, great burdock achene, the root of purple-flowered peucedanum, iron holly bark.The Chinese medicine preparation of present invention treatment transmissible gastroenteritis of swine have anti-inflammation, ataralgesia, Shengyang Zhixie, clearing heat and detoxicating, strengthening spleen and nourishing stomach, qi-regulating help digestion and enhance immunity effect, the transmissible gastroenteritis disease with treatment pig can effectively be prevented, the characteristics of being easy to get with raw material, make simple, low cost, good effect, have no toxic side effect and be administered convenient.
Description
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, more particularly to a kind of Chinese medicine system for treating transmissible gastroenteritis of swine
Agent and preparation method.
Background technology
Pig stomach enteritis is a kind of high degree in contact communicable intestinal diseases caused by marcy agent, with vomiting, serious abdomen
Rush down, be dehydrated, cause the viral infectious that piglet high mortality is characterized in two week old.After Infection in Piglets within general 2 week old
Vomiting occurs within 12-24 hours, serious water sample or pasty state diarrhoea then occur, excrement is in yellow, is often accompanied indigested solidifying
Newborn block, stench, body weight declines rapidly, and piglet is substantially dehydrated, morbidity death in 2-7 days, and the death rate is up to 100%；In the son of 2-3 week old
Pig, the death rate can be controlled in less than 10%.Fallen ill within 2-4 days after ablactation pig infection, performance watery diarrhea, in spurting, excrement gray or
Brown, indivedual pig vomitings, suffered from diarrhoea after 5-8 days and stops, few dead, but Body weight loss, depauperation was often showed, as deadlock
Pig.Some sows and ill piglet close contact repeated infection, symptom are heavier, and body temperature is raised, and lactation stops, and vomiting, appetite are not
Shake and suffer from diarrhoea, also some milking sows do not show clinical symptom.
Preferable treatment method there is no to transmissible gastroenteritis of swine doctor trained in Western medicine at present, also without specific drug, the method taken is only
It is, to mitigate symptom, to reduce dead, the shortening course of disease, reduces loss.For prevent the disease generation and prevalence frequently with vaccine inoculation
Therapy, but vaccine influenceed by many uncertain factors, and often actual effect is not good enough, controls above-mentioned disease to have completely by vaccine
Great difficulty.Using hyper-immune serum, Yolk antibody treats this disease, although curative effect is preferably, cost is too high.Without restraint abuse chemical drug,
Antibiotic and monomer medicine, had both produced polynary anti-medicine and the super many drug induced diseases such as quick of acceptor, caused animal products to pollute again,
Jeopardize human food safe and healthy.Chinese medicine derives from animal, plant and mineral matter, containing various biological effective components, wherein greatly
Most Chinese medicines be with natural plants as raw material, with aboundresources, easily obtain, work well, cheap, toxic and side effect
It is small, almost noresidue, without the resistance to the action of a drug and free from environmental pollution.And in the prior art on the Chinese medicinal herb medicament for the treatment of pig stomach enteritis
It is less, and majority uses oral administration, generally existing administration is difficult, it is difficult absorb, slow drug effect and the problems such as weak curative effect.Cause
This, invent it is a kind of be administered directly, drug effect is fast, eutherapeutic treatment transmissible gastroenteritis of swine Chinese medicine preparation substitutes chemical drug, anti-
Raw element turns into art technology problem.
The content of the invention
It is an object of the present invention to be directed to above-mentioned the deficiencies in the prior art, there is provided a kind of transmissible gastroenteritis of swine for the treatment of
Chinese medicine preparation and preparation method.The Chinese medicine preparation of present invention treatment transmissible gastroenteritis of swine has anti-inflammation, ataralgesia, liter
Positive antidiarrheal, clearing heat and detoxicating, strengthening spleen and nourishing stomach, qi-regulating help digestion and enhance immunity effect, can effectively prevent and treat pig
Transmissible gastroenteritis disease, is easy to get with raw material, makes simple, low cost, good effect, has no toxic side effect and is administered and be easily special
Point.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：Bitter dish 30-60 parts, muscle
15-40 parts of bone grass, 8-15 parts of mountain lettuce, baked ginger 10-20 parts, 5-10 parts of iron railing, six 10-18 parts of songs, Sargent gloryvine 3-8 parts, it is half of
Lotus 5-10 parts, Herba Ixeritis polycephalae 8-15 parts of 10-20 parts of, Thlaspi, 6-12 parts of southern Guangdong birthwort, osbeckia 4-8 parts, catchweed bedstraw herb 2-6 parts,
Chinese Fevervine Herb 1-5 parts, manyleaf meadowure rhizome and root 3-5 parts, polygonum flaccidum 1-5 parts, Glabrous Sarcandra Herb 3-8 parts, great burdock achene 1-5 parts, root of purple-flowered peucedanum 1-5 parts and iron holly bark 1-
8 parts.
Further, it is made by the raw material of following parts by weight：Bitter dish 40-55 parts, carpet bugle 20-35 parts, mountain lettuce
Lettuce 10-13 parts, baked ginger 12-18 parts, 5-8 parts of iron railing, six 12-15 parts of songs, Sargent gloryvine 5-8 parts, Chinese lobelia 6-8 parts, Herba Ixeritis polycephalae
10-13 parts of 12-18 parts of, Thlaspis, 8-10 parts of southern Guangdong birthwort, osbeckia 5-8 parts, catchweed bedstraw herb 3-5 parts, Chinese Fevervine Herb 2-4 parts, horse hair
Even 3-4 parts, polygonum flaccidum 2-5 parts, Glabrous Sarcandra Herb 4-6 parts, great burdock achene 2-4 parts, root of purple-flowered peucedanum 1-3 parts and iron holly bark 2-6 parts.
Further, it is made by the raw material of following parts by weight：50 parts of bitter dish, 30 parts of carpet bugle, 12 parts of mountain lettuce,
15 parts of baked ginger, 6 parts of iron railing, six 13 parts of songs, 7 parts of Sargent gloryvine, 7 parts of Chinese lobelia, 12 parts of Herba Ixeritis polycephalae, 15 parts of, Thlaspis, southern Guangdong horse pocket
It is 9 parts of bell, 7 parts of osbeckia, 4 parts of catchweed bedstraw herb, 3 parts of Chinese Fevervine Herb, 4 parts of manyleaf meadowure rhizome and root, 4 parts of polygonum flaccidum, 5 parts of Glabrous Sarcandra Herb, 3 parts of great burdock achene, preceding
2 parts and 5 parts of iron holly bark recklessly.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 30-90 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, is put into
Pulverizer, crushes 10-30 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 5-8 times of its weight, decocts 3-5 hours, filters drug
Slag, repeats to decoct 2-4 times, merges each fried liquid, and concentration obtains concentrate, the wherein concentrate and the gross weight of raw material
Than being 1：（0.8-1.2）；
3rd step, takes second step concentrate, adds ethanol to make alcohol content for 60-80%, and regulation pH value to 7.5-8.5 stands 18-
Filtered after 24 hours, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 60-150 minutes, obtains particle diameter and is less than 2 μm
The mixed powder of the nano-scale particle of volume average particle size, the powder rate that obtains of the mixed powder is no less than 85%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 5-100ml, both described treat pig transmissible stomach
The Chinese medicine preparation of enteritis.
The raw material pharmacology of the Chinese medicine preparation of the above treatment transmissible gastroenteritis of swine is analyzed as follows：
Bitter dish：Latin name：Sonchus oleraceus L., alias：Day coriander, the bitter edible plant hardship pod, Gan Macai, old stork dish, without caraway
Deng medicine name：Field pennycress, different name：Maiden spends, deer intestines horse grass.Bitter, it is cold in nature, with anti-inflammation, clearing heat and detoxicating, improving eyesight and stomach,
The effect of removing heat from the blood and relieve diarrhea etc..Bitter dish not only contain 5 kinds of vitamins and 17 kinds of amino acid, also separately contain taraxasterol, mannitol etc.
Multiple components, to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus, Diplococcus pneumopniae, meningococcus, diphtheria bar
Bacterium, Pseudomonas aeruginosa, shigella dysenteriae etc. have obvious inhibitory action with certain lethal effect to haemocyte deoxygenase,
There is control and therapeutic action well to inflammation, be usually used in treatment appendicitis, peritoneal abscess, enteritis, dysentery, pelvic infecton, lung
The symptoms such as heat cough, pulmonary tuberculosis, haematemesis, bleeding from five sense organs or subcutaneous tissue.It is monarch drug in a prescription that Chinese medicine preparation of the present invention uses bitter dish, in its abundant extract,
With good antiinflammatory action, while suppression with inflammation is repaired, moreover it is possible to supplement multivitamin and amino acid to body, favorably
In acceleration state of an illness rehabilitation.
Carpet bugle：Latin name：Ajuga ciliata Bunge., Lamiales Labiatae bugle.Alias：White hair
Selfheal, clarke boea herb, POXUE DAN.Its bitter, it is cold in nature, with antibechic, eliminating the phlegm, relieving asthma, heat-clearing, removing toxic substances, cool blood, the work(such as soothing the liver
Effect, be usually used in the infection of the upper respiratory tract, tonsillitis, pharyngitis, bronchitis, pneumonia, lung abscess, enterogastritis, hepatitis, appendicitis,
Mastitis, acute conjunctivitis, hypertension.Though carpet bugle has good curative effect to all kinds of inflammation, its property of medicine is relatively trembled with fear, and is easily caused
Body is uncomfortable or other symptoms occurs, and the present invention is as ministerial drug playing more preferable auxiliaring effect.By fry technique and
Addition baked ginger, relaxes its cold so that Chinese medicine preparation of the present invention is more easy to be received by body.
Mountain lettuce：Latin name：Lagedium sibiricum （L.）Sojak, belongs to chrysanthemum mesh, and composite family perennial herb is high
50-130 centimetres.Cold in nature, bitter has the effect of clearing heat and detoxicating, promoting blood circulation, stomach invigorating, can treat appendicitis, tonsillitis, sore
Furuncle poison, place food do not disappear, postpartum blood stasis.Coordinated using mountain lettuce and baked ginger and go to assist a ruler in governing a country bitter dish and carpet bugle, can not only improved
The property of medicine, can also improve antiphlogistic effects and protection stomach.
Baked ginger:Chinese medicine name, is the Preparation process product of rhizoma zingiberis.Gas is fragrant, special, taste micro-pungent, peppery, returns spleen, stomach, kidney channel.Often
Lost blood for treating the deficiency of yang, hematemesis uterine bleeding, deficiency-cold in spleen and stomach, stomachache vomit and diarrhoea.Baked ginger can not only improve deficiency-cold in spleen and stomach, stomachache and vomit and diarrhoea
Symptom, part in Chinese medicine preparation of the present invention can also be relaxed and trembled with fear partially the property of medicine of raw material, it is to avoid the property of medicine is trembled with fear and causes stomach partially
It is uncomfortable.
Iron railing：Chinese medicine name, is Campanulaceae lobelia plant tower flower Lobelia sessilifolia Lobelia pyramidalis Wall.
Herb.Taste is pungent, slight bitter, it is mild-natured.With removing toxicity for detumescence, the effect of desinsection.Cure mainly boil on the nape, acute appendicitis, pruitus.Iron railing
There is to kill enteron aisle disease pest to sick pig, repair intestinal wall and fester face.
Six is bent：Chinese medicine name, through hair after being mixed using the medicines such as almond mud, rde bean, flaccid knotweed herb, sweet wormwood, flour, Siberian cocklebur grass end
The processed goods of ferment.It is sweet, pungent, it is warm in nature, enter spleen, stomach.There is and eat the stomach that disappears.For accumulation of food in the stomach and intes tine due to indigestion, the vexed abdomen of gastral cavity
It is swollen, the disease such as indigestion and diarrhea.Addition Medicated Leaven can improve indigestion, increase appetite, promote stomach to absorb.
Sargent gloryvine：Latin name：Sargentodoxa cuneata., are Lardizabalaceae, Saggentodoxa fallen leaves, bejuco.
Bitter, it is mild-natured, return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, clearing and activating the channels and collaterals, promoting blood circulation and stopping pain, dispelling wind and eliminating dampness, disinsection efficiency.Cure mainly intestines
Carbuncle, dysentery, newborn pain, dysmenorrhoea, Amenorrhea, traumatic injury, arthralgia pain due to rheumatism, abdominal pain due to enterositosis.
Chinese lobelia：Latin name：Lobelia chinensis Lour., another name：Edible kernel of melon seeds grass, anxious solution rope, thin rice grass, balloonflower root
Section's lobelia perennial herb.Herb is medicinal, containing various alkaloids, there is clearing heat and detoxicating, inducing diuresis to remove edema effect, controls poisonous snake and stings
Wound, cirrhotic ascites, advanced schistosomiasis ascites, enteritis effect etc..
Herba Ixeritis polycephalae:Chinese medicine name, is the herb of feverfew Herba Ixeritis polycephalae Ixeris polycephala Cass., taste
It is bitter, sweet, cool in nature, return liver warp.With clearing heat and detoxicating, the effect of dampness removing；It is usually used in treatment lung heat laryngalgia, stomachache, lump in the abdomen, appendix
It is scorching.
Thlaspi：Latin name：Thlaspi arvense L., another name：Penny cress, field pennycress, viola japonica.Herb can be used as medicine,
With clearing liver and improving vision, the effects such as reducing fever and causing diuresis, ephritis, endometritis are cured mainly.It is edible.Herb：Clearing heat and detoxicating, dampness removing disappears
It is swollen, and middle appetizing.For appendicitis, lung abscess, carbuncle furuncle poison, erysipelas, endometritis, leukorrhea, ephritis, cirrhotic ascites,
Children's indigestion.Seed：Dispelling wind and eliminating dampness, and stomach and alleviating pain.For rheumatic arthritis, pain in the back, acute conjunctivitis, stomachache, liver
It is scorching.It is sweet, put down.With middle QI invigorating, sharp gas, detumescence, clearing heat and detoxicating, sharp liver improving eyesight.
Southern Guangdong birthwort：Latin name：Aristolochia howii Merr. et Chun., alias：How dutchmanapipe root,
Wang larynx and, Ya Bulun, be Aristolochiaceae, Aristolochia, woody climber.The root tuber hyoscine of southern Guangdong birthwort, has antibacterial, disappears
The scorching, effect of removing toxic substances；Control hyperpyrexia, pneumonia and laryngalgia etc..
Osbeckia：Latin literary fame：Osbeckia chinensis L., alias：Cup is careless, small back of the body cage, thin flower bag, Zhang Tian
Cylinder, high day alley, sub Radix Osbeckia Crinitae, thin nine chi, golden incense burner, Zhuan yong, Melochia corchorifolia L, osbeckia chinensis.It is mild-natured, it is taste micro-sweet, puckery.Function master
Control：Clearing heat and promoting diuresis, subdhing swelling and detoxicating is relieving cough and reducing sputum.For acute bacillary dysentery, amoebic dysentery, amoeba liver abscess, intestines
Inflammation, cold cough, abscess of throat, children's bronchus asthma, hemoptysis of pulmonary tuberculosis, appendicitis, venomous snake bite, furunculosis furuncle.
Catchweed bedstraw herb:Latin name：Tender Catchweed Bedstraw Herb, also known as aizoon stonecrop, blood circulation promoting pill, see blood
Scattered, Sedum uizoon, clearvers, acalyphae,herba etc., are crassulaceae plants.Bitter, pungent, cold in nature, Gui Shaoyin, Taiyin channels, with heat-clearing solution
Toxic action, cure mainly swollen ulcer drug, mastitis, appendicitis, oedema, cold, fever, dysentery, urinary tract infections, hematuria, bleeding gums,
Knife wound bleeding.
Chinese Fevervine Herb：Chinese medicine name, another name：Fevervine, ox-hide freeze, smelly rattan, are the herb of madder wort Chinese Fevervine Herb.Its taste
Sweet, slight bitter, mild-natured, the thoughts of returning home, liver,spleen,kidney warp.The effect of with expelling wind and removing dampness, promoting digestion and removing indigestion, cough-relieving, analgesic.For treating wind
Wet muscle and bone ache, traumatic injury, traumatic pain, diarrhoea, dysentery, indigestion, infantile malnutrition, tuberculosis spitting of blood, liver and gall and stomach and intestine
Leukopenia and pesticide poisoning that angina, jaundice type hepatitis, bronchitis, radioreaction cause.Chinese Fevervine Herb can not only
Pain of alleviation, also with the effect for promoting promoting digestion and removing indigestion.
Manyleaf meadowure rhizome and root：Chinese medicine name, alias Radix et Rhizoma Thalictri is the leafy grass of meadow rue Thalictrum of Ranunculaceae thalictrum spp
Foliolosum DC. and plateau grass of meadow rue T.cultratum Wall.T. deciternatum Boiv, are used as medicine with root.
Bitter, it is cold in nature, enter the heart, liver, courage, large intestine channel.Effect with heat-clearing and damp-drying drug, removing toxic substances, is usually used in treatment dysentery, enteritis, infection
Property hepatitis, flu, measles, conjunctivitis etc..
Polygonum flaccidum：Chinese medicine name, is the herb of polygonaceae arsesmart water pepper Polygonum hydropiper L..It is taste is pungent, peppery,
It is warm in nature, return stomach, large intestine channel.With expelling wind and removing dampness, blood stasis removing analgesic, removing toxicity for detumescence, the effect of desinsection is antipruritic.It is usually used in dysentery, stomach
The treatment of the illnesss such as enteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, functional uterine bleeding；It is used for venomous snake bite, skin outward
Eczema.
Glabrous Sarcandra Herb：Alias：Synthetism tree, sarcandra, nine joint flower, Herba Pileae Scriptae, ring tea, synthetism lotuses, kwan-yin tea, synthetism
Wood, Herba Pileae Scriptae, refute section tea, duck pin section, the mountain root of bidentate achyranthes, Chloranthus spicatus Mak, veronica, Baptisia, Xue Shicha, lindenleaf torricellia bark or leaf, Sambucus thunbergiana, copper pin spirit
Celestial being, Herba Sarcandrae Inj, section bone tea, synthetism lotuses, bamboo tea, are that Chloranthaceae plant Chloranthus glaber dries complete stool.It is bitter, pungent, it is mild-natured, return
The heart, Liver Channel.There is anti-inflammation, clearing heat and detoxicating, dispelling wind and removing obstruction in the meridians, blood circulation promoting and dispersing pathogen accumulation, for pneumonia, acute appendicitis, urgency
Property gastroenteritis, cellulitis belong to heat toxin and stop up and contain patient, and arthralgia pain due to rheumatism, injury from falling down, tumour auxiliary treatment.
Great burdock achene：Latin name：Fructus Arctii, are the dry mature fruit of composite family biennial herb plant burdock.
Taste is pungent, hardship, it is cold in nature, attach to the lung and stomach meridians.With dispelling wind and heat from the body, facilitaing lung promoting eruption, relieving sore-throat dissipating bind, the effect of removing toxicity for detumescence.Belong to inducing diaphoresis
Wind-heat-dispersing medicinal in medicine.The symptom of sick pig body surface heating can be alleviated.
The root of purple-flowered peucedanum：Chinese medicine name, is the dry root of samphire RADIX PEUCEDANI Peucedanum praeruptorum Dunn.
Bitter, pungent, cold nature.Return lung is passed through.With lowering the adverse-rising QI to resolve phlegm, effect of wind heat-clearing is dissipated.Full, cough up phlegm yellow thick, wind-heat for phlegm heat panting
Coughing with a lot of sputum.The symptoms such as sick pig respiratory tract product phlegm, unsmooth breath can effectively be alleviated.
Iron holly bark：Latin name：Ilex rotunda Thunb, Chinese name：Hex godajam (colebr) Wall, is holly plant Ilex
Rotunda Thunb., belong to aiphyllium or shrub.It is cold in nature, bitter, return lung, liver, large intestine channel.With clearing heat and detoxicating, dampness removing,
The effect of analgesic, is usually used in treatment cold, fever, abscess of throat, stomachache, summer heat damp diarrhea, jaundice, dysentery, traumatic injury, rheumatism
Numbness pain, eczema, boil.There is preferably effect to alleviating pain and diarrhoea in sick pig abdomen.
In sum, due to using above-mentioned technical proposal, the beneficial effects of the invention are as follows：
1. the Chinese medicine preparation of present invention treatment pig stomach enteritis, from natural Chinese medicinal herb plant, is made through science.Wherein with
Bitter dish are monarch drug in a prescription, not only with anti-inflammation, clearing heat and detoxicating, improving eyesight and stomach, the effect of removing heat from the blood and relieve diarrhea etc., also containing 5 kinds of vitamins,
The Multiple components such as 17 kinds of amino acid, taraxasterol, mannitol, have obvious inhibitory action so that control to haemocyte deoxygenase
While treating enterogastritis, moreover it is possible to supplement multivitamin and amino acid to body, be conducive to accelerating state of an illness rehabilitation；Carpet bugle has
The effects such as clearing heat and detoxicating, cool blood flat liver, the traditional Chinese medical science is usually used in lung abscess, enterogastritis, hepatitis, appendicitis, mastitis, acute conjunctiva
The symptoms such as inflammation, hypertension, but its property of medicine is relatively cold, and the young pig for a week old will be run counter to desire with this medicine.But by frying technique
And coordinate baked ginger, and to relax and be used to assist a ruler in governing a country bitter dish as ministerial drug after the property of medicine of carpet bugle, the overall drug effect of significant increase；The mountain lettuce
Lettuce, baked ginger, iron railing, six songs, Sargent gloryvine, Chinese lobelia, Herba Ixeritis polycephalae, Thlaspis, southern Guangdong birthwort, osbeckia, catchweed bedstraw herb, chicken droppings
Rattan, manyleaf meadowure rhizome and root, polygonum flaccidum, Glabrous Sarcandra Herb, great burdock achene, the root of purple-flowered peucedanum and iron holly bark are helped altogether, with clearing heat and detoxicating, anti-inflammation and sterilization, anti-vomiting,
The effects such as warm stomach ease constipation, invigorating the spleen are transported wet, promoting digestion and removing indigestion, defaecation qi-regulating, Shengyang Zhixie, analgesic hemostatic, desinsection and attack long-pending, with bitter dish,
Carpet bugle group 5, all medicines are played altogether, and healthy tendency is unobstructed, and heresy is inverse to be removed certainly.The preparation method of the Chinese medicine preparation fries technique by slow fire,
Curative effect of the raw materials such as bitter dish, carpet bugle to Transmissible Gastroenteritis can not only be strengthened, after each Chinese medicine material compatibility can also be relaxed
The property of medicine, make last obtained Chinese medicine preparation that there is the property of medicine and more preferable curative effect of milder；With in water extraction dissolving medicinal material
Active ingredient, greatly reduce production cost；There is feature oral, that injection is dual-purpose, significant increase using injection form
The convenience of administration.
2. the Chinese medicine preparation of present invention treatment transmissible gastroenteritis of swine, without antibiotic etc, is not likely to produce resistance
Property, and it is nontoxic, have no side effect, noresidue, meet《Veterinary medical quality standard》、《Feed medicated premix operating specification》Requirement,
The features such as with fast convenient, drug effect, good effect is administered, be a kind of Chinese medicine system of ideal treatment transmissible gastroenteritis of swine
Agent.
Specific embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：30 parts of bitter dish, carpet bugle
40 parts, 8 parts of mountain lettuce, 20 parts of baked ginger, 5 parts of iron railing, six bent 18 parts, 3 parts of Sargent gloryvine, 10 parts of Chinese lobelia, 8 parts of Herba Ixeritis polycephalae, Xi
120 parts of Mi, 6 parts of southern Guangdong birthwort, 8 parts of osbeckia, 2 parts of catchweed bedstraw herb, 5 parts of Chinese Fevervine Herb, 3 parts of manyleaf meadowure rhizome and root, 5 parts of polygonum flaccidum, Glabrous Sarcandra Herb 3
Part, 5 parts of great burdock achene, 1 part of the root of purple-flowered peucedanum and 8 parts of iron holly bark.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 30 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, puts into powder
Broken machine, crushes 10 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 5 times of its weight, decocts 3 hours, filters out the dregs of a decoction,
Repeat to decoct 4 times, merge each fried liquid, concentration obtains concentrate, and wherein concentrate and the ratio of the gross weight of raw material is 1：
0.8；
3rd step, takes second step concentrate, adds ethanol to make alcohol content be 60%, regulation pH value to 7.5, mistake after standing 24 hours
Filter, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 60 minutes, obtains particle diameter and is less than 2 μm of volumes
The mixed powder of the nano-scale particle of average grain diameter, the powder rate that obtains of the mixed powder is no less than 85%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 5ml, both the treatment transmissible gastroenteritis of swine
Chinese medicine preparation.
Embodiment 2
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：60 parts of bitter dish, carpet bugle
15 parts, 15 parts of mountain lettuce, 10 parts of baked ginger, 10 parts of iron railing, six bent 10 parts, 8 parts of Sargent gloryvine, 5 parts of Chinese lobelia, 15 parts of Herba Ixeritis polycephalae,
10 parts of Thlaspi, 12 parts of southern Guangdong birthwort, 4 parts of osbeckia, 6 parts of catchweed bedstraw herb, 1 part of Chinese Fevervine Herb, 5 parts of manyleaf meadowure rhizome and root, 1 part of polygonum flaccidum, swollen section
1 part of 8 parts of wind, 1 part of great burdock achene, 5 parts of the root of purple-flowered peucedanum and iron holly bark.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 90 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, puts into powder
Broken machine, crushes 30 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 8 times of its weight, decocts 5 hours, filters out the dregs of a decoction,
Repeat to decoct 2 times, merge each fried liquid, concentration obtains concentrate, and wherein concentrate and the ratio of the gross weight of raw material is 1：
1.2；
3rd step, takes second step concentrate, adds ethanol to make alcohol content be 80%, regulation pH value to 8.5, mistake after standing 18 hours
Filter, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 150 minutes, obtains particle diameter and is less than 2 μm of volumes
The mixed powder of the nano-scale particle of average grain diameter, the powder rate that obtains of the mixed powder is no less than 90%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 100ml, both described treat pig transmissible stomach and intestine
Scorching Chinese medicine preparation.
Embodiment 3
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：40 parts of bitter dish, carpet bugle
35 parts, 10 parts of mountain lettuce, 18 parts of baked ginger, 5 parts of iron railing, six bent 15 parts, 5 parts of Sargent gloryvine, 8 parts of Chinese lobelia, 10 parts of Herba Ixeritis polycephalae, Xi
18 parts of Mi, 8 parts of southern Guangdong birthwort, 8 parts of osbeckia, 3 parts of catchweed bedstraw herb, 4 parts of Chinese Fevervine Herb, 3 parts of manyleaf meadowure rhizome and root, 5 parts of polygonum flaccidum, Glabrous Sarcandra Herb 4
Part, 4 parts of great burdock achene, 1 part of the root of purple-flowered peucedanum and 6 parts of iron holly bark.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 50 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, puts into powder
Broken machine, crushes 15 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 6 times of its weight, decocts 3 hours, filters out the dregs of a decoction,
Repeat to decoct 4 times, merge each fried liquid, concentration obtains concentrate, and wherein concentrate and the ratio of the gross weight of raw material is 1：
0.9；
3rd step, takes second step concentrate, adds ethanol to make alcohol content be 65%, regulation pH value to 7.5, mistake after standing 22 hours
Filter, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 80 minutes, obtains particle diameter and is less than 2 μm of volumes
The mixed powder of the nano-scale particle of average grain diameter, the powder rate that obtains of the mixed powder is no less than 86%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 10ml, both described treat pig transmissible stomach and intestine
Scorching Chinese medicine preparation.
Embodiment 4
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：55 parts of bitter dish, carpet bugle
20 parts, 13 parts of mountain lettuce, 12 parts of baked ginger, 8 parts of iron railing, six bent 12 parts, 8 parts of Sargent gloryvine, 6 parts of Chinese lobelia, 13 parts of Herba Ixeritis polycephalae, Xi
12 parts of Mi, 10 parts of southern Guangdong birthwort, 5 parts of osbeckia, 5 parts of catchweed bedstraw herb, 2 parts of Chinese Fevervine Herb, 4 parts of manyleaf meadowure rhizome and root, 2 parts of polygonum flaccidum, Glabrous Sarcandra Herb 6
Part, 2 parts of great burdock achene, 3 parts of the root of purple-flowered peucedanum and 2 parts of iron holly bark.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 70 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, puts into powder
Broken machine, crushes 25 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 7 times of its weight, decocts 5 hours, filters out the dregs of a decoction,
Repeat to decoct 2 times, merge each fried liquid, concentration obtains concentrate, and wherein concentrate and the ratio of the gross weight of raw material is 1：
1.1；
3rd step, takes second step concentrate, adds ethanol to make alcohol content be 75%, regulation pH value to 8.5, mistake after standing 19 hours
Filter, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 130 minutes, obtains particle diameter and is less than 2 μm of volumes
The mixed powder of the nano-scale particle of average grain diameter, the powder rate that obtains of the mixed powder is no less than 89%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 50ml, both described treat pig transmissible stomach and intestine
Scorching Chinese medicine preparation.
Embodiment 5
The Chinese medicine preparation of transmissible gastroenteritis of swine is treated, is made by the raw material of following parts by weight：50 parts of bitter dish, carpet bugle
30 parts, 12 parts of mountain lettuce, 15 parts of baked ginger, 6 parts of iron railing, six bent 13 parts, 7 parts of Sargent gloryvine, 7 parts of Chinese lobelia, 12 parts of Herba Ixeritis polycephalae, Xi
15 parts of Mi, 9 parts of southern Guangdong birthwort, 7 parts of osbeckia, 4 parts of catchweed bedstraw herb, 3 parts of Chinese Fevervine Herb, 4 parts of manyleaf meadowure rhizome and root, 4 parts of polygonum flaccidum, Glabrous Sarcandra Herb 5
Part, 3 parts of great burdock achene, 2 parts of the root of purple-flowered peucedanum and 5 parts of iron holly bark.
The preparation method of the Chinese medicine preparation for the treatment of transmissible gastroenteritis of swine of the present invention, comprises the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 60 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, puts into powder
Broken machine, crushes 20 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 6 times of its weight, decocts 4 hours, filters out the dregs of a decoction,
Repeat to decoct 3 times, merge each fried liquid, concentration obtains concentrate, and wherein concentrate and the ratio of the gross weight of raw material is 1：
1；
3rd step, takes second step concentrate, adds ethanol to make alcohol content be 70%, and regulation pH value to 8 is filtered after standing 20 hours,
Filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 100 minutes, obtains particle diameter and is less than 2 μm of volumes
The mixed powder of the nano-scale particle of average grain diameter, the powder rate that obtains of the mixed powder is no less than 88%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 20ml, both described treat pig transmissible stomach and intestine
Scorching Chinese medicine preparation.
Above-mentioned 5 kinds of embodiments are made Chinese medicine preparation separately below, carries out toxicity test and curative effect contrast test, its examination
Test as follows：
First, toxicity test：
Healthy mice 50 of the body weight in 35-50g is taken, 5 groups are bisected at random, in being made using above-mentioned 5 kinds of embodiments respectively
Medicine preparation, twice, per injection dosage is 5ml for injection daily, continuous injection 10 days, and all mouse are strong after 10 days deposits, its activity,
Diet has strengthened, but hair, excreta are no abnormal, have no toxic reaction；11st day to murine oral and damaged skin
Irritation test is carried out, irritative response or other abnormal responses are there are no；Slaughter within 12nd day, each group mice organs are disease-free
Become, blood picture and GPT detections are in normal range (NR).
Toxicity sample proves, the non-toxic side effect of Chinese medicine preparation of present invention treatment transmissible gastroenteritis of swine and bad anti-
Should, practical application is safe and reliable.
2nd, curative effect contrast test：
1-2 week old sick pig of the natural occurrence with transmissible gastroenteritis, therefrom blind at random to select 7 groups in certain market pig breeding base
（Control group 1, control group 2, embodiment group 1, embodiment group 2, embodiment group 3, embodiment group 4 and embodiment group 5）, every group 10
Sick pig, control group 1 uses florfenicol powder（Every sick pig medication 0.1g/ times, daily 2 times, pulvis is watered and gavages）, control group 2
It is clear using intestines poison（Every sick pig medication 0.4g/ times, daily 2 times, pulvis is watered and gavages）, embodiment group 1-5 is respectively using corresponding
Chinese medicine preparation prepared by embodiment 1-5（Every sick pig medication 10ml/ times, daily 2 times, intravenous injection）, continuous use stops after 6 days
Medicine and continuous observation, each group isolated rearing, other cultivating conditions are identical.3 stages were divided into by 6 days of medication, are recorded respectively
The curative effect in each stage and the recurrence rate in 14 days, as a result as shown in table 1.
The Chinese medicine preparation of the present invention of table 1 and control group clinical trial data
Knowable to the data of table 1：Control group 1 is watered using florfenicol powder and gavaged, and cure rate in the first stage is up to 60%,
But second and third stage cure rate is respectively 70%, 80%, its ascendant trend rapid drawdown substantially, and in 14 days high recurrence rate up to 50%,
Prove that antibioticses florfenicol powder has early stage evident in efficacy to controlling pig treatment gastroenteritis, and there is easy resistance, easily recurrence in the later stage
Shortcoming；Control group 2 is gavaged using clear being watered of intestines poison, and cure rate in the first stage is up to 70%, but second and third stage is controlled
More rate is all 80%, and its ascendant trend rapid drawdown is simultaneously scattered and disappeared, and in 14 days high recurrence rate up to 60%, it was demonstrated that antibioticses intestines poison is clear to controlling
Pig treats gastroenteritis has early stage evident in efficacy, and the later stage haves the shortcomings that easy resistance, easily recurrence；Embodiment group 1-5 is injected respectively
Chinese medicine preparation obtained in embodiment 1-5, the cure rate average value in first, second, third stage is respectively 30%, 58%, 86%, its
Ascendant trend stabilization and uniform, the phase III cure rate average value apparently higher than two groups of control groups, and the recurrence in 14 days
Rate average value is only 10%, hence it is evident that less than two groups of control groups, it was demonstrated that Chinese medicine preparation has to pig stomach enteritis obtained in embodiment 1-5
Good curative effect, body itself has had certain immunocompetence after drug withdrawal.
Above example is only presently preferred embodiments of the present invention, is not intended to limit the invention, all in spirit of the invention
Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (4)
1. the Chinese medicine preparation of transmissible gastroenteritis of swine is treated, it is characterised in that be made by the raw material of following parts by weight：It is bitter
Dish 30-60 parts, carpet bugle 15-40 parts, 8-15 parts of mountain lettuce, baked ginger 10-20 parts, it is 5-10 parts of iron railing, six 10-18 parts of songs, red
Rattan 3-8 parts, Chinese lobelia 5-10 parts, Herba Ixeritis polycephalae 8-15 parts of 10-20 parts of, Thlaspi, 6-12 parts of southern Guangdong birthwort, osbeckia 4-8 parts,
Catchweed bedstraw herb 2-6 parts, Chinese Fevervine Herb 1-5 parts, manyleaf meadowure rhizome and root 3-5 parts, polygonum flaccidum 1-5 parts, Glabrous Sarcandra Herb 3-8 parts, great burdock achene 1-5 parts, root of purple-flowered peucedanum 1-5
Part and iron holly bark 1-8 parts.
2. the Chinese medicine preparation of transmissible gastroenteritis of swine is treated according to claim 1, it is characterised in that by following parts by weight
Raw material be made：Bitter dish 40-55 parts, carpet bugle 20-35 parts, 10-13 parts of mountain lettuce, baked ginger 12-18 parts, iron railing 5-8
Part, six 12-15 parts of songs, Sargent gloryvine 5-8 parts, Chinese lobelia 6-8 parts, Herba Ixeritis polycephalae 10-13 parts of 12-18 parts of, Thlaspis, southern Guangdong birthwort 8-
10 parts, osbeckia 5-8 parts, catchweed bedstraw herb 3-5 parts, Chinese Fevervine Herb 2-4 parts, manyleaf meadowure rhizome and root 3-4 parts, polygonum flaccidum 2-5 parts, Glabrous Sarcandra Herb 4-6 parts, ox
Burdock 2-4 parts, root of purple-flowered peucedanum 1-3 parts and iron holly bark 2-6 parts.
3. the Chinese medicine preparation of transmissible gastroenteritis of swine is treated according to claim 1, it is characterised in that by following parts by weight
Raw material be made：50 parts of bitter dish, 30 parts of carpet bugle, 12 parts of mountain lettuce, 15 parts of baked ginger, 6 parts of iron railing, six bent 13 parts, it is red
7 parts of rattan, 7 parts of Chinese lobelia, 12 parts of Herba Ixeritis polycephalae, 15 parts of, Thlaspis, 9 parts of southern Guangdong birthwort, 7 parts of osbeckia, 4 parts of catchweed bedstraw herb, chicken droppings
5 parts of 3 parts of rattan, 4 parts of manyleaf meadowure rhizome and root, 4 parts of polygonum flaccidum, 5 parts of Glabrous Sarcandra Herb, 3 parts of great burdock achene, 2 parts of the root of purple-flowered peucedanum and iron holly bark.
4. according to the preparation method of the Chinese medicine preparation of any treatment transmissible gastroenteritis of swine in claim 1-3, its feature
It is：Comprise the following steps：
The first step, each raw material Chinese medicine is shredded, and slow fire is fried 30-90 minutes after mixing in proportion, is dried in the air after stir-bake to yellowish cool, is put into
Pulverizer, crushes 10-30 minutes, obtains mixing medicinal material of the particle diameter less than 2mm volume average particle sizes；
Second step, the mixing medicinal material for taking first step acquisition adds the water of relative 5-8 times of its weight, decocts 3-5 hours, filters drug
Slag, repeats to decoct 2-4 times, merges each fried liquid, and concentration obtains concentrate, the wherein concentrate and the gross weight of raw material
Than being 1：（0.8-1.2）；
3rd step, takes second step concentrate, adds ethanol to make alcohol content for 60-80%, and regulation pH value to 7.5-8.5 stands 18-
Filtered after 24 hours, filtrate recycling ethanol, concentration is dried, and obtains dry cream；
4th step, the dry cream that the 3rd step is obtained puts into Ultramicrofine crasher, crushes 60-150 minutes, obtains particle diameter and is less than 2 μm
The mixed powder of the nano-scale particle of volume average particle size, the powder rate that obtains of the mixed powder is no less than 85%；
5th step, takes the mixed powder 5g of the 4th step acquisition, adds 100g sodium chloride, adds 1000ml waters for injection, stirs
Dissolve it, with 0.45 μm of filtering with microporous membrane, sterilizing packing embedding, every bottle of 5-100ml, both described treat pig transmissible stomach
The Chinese medicine preparation of enteritis.
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| CN107242375A (en) * | 2017-07-25 | 2017-10-13 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent and treat feed of transmissible gastroenteritis of swine and preparation method thereof |
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