CN103719552B - Feed for preventing and treating swine erysipelas and preparation method for feed - Google Patents
Feed for preventing and treating swine erysipelas and preparation method for feed Download PDFInfo
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Abstract
The invention discloses a feed for preventing and treating swine erysipelas and a preparation method for the feed. The feed comprises the following raw materials of barley, wheat, composite enzyme, yam powder, methionine, threonine, vitamin premix and a traditional Chinese medicinal additive. The feed disclosed by the invention has the beneficial effects that the feed contains the traditional Chinese medicinal additive for treating the swine erysipelas, and the main therapeutic principle of the traditional Chinese medicinal additive is to clear away heat and purge pathogenic fire, nourish yin, promote the secretion of saliva or body fluid, regulate qi and blood and regulate spleen and stomach; the traditional Chinese medicinal additive and other feed raw materials are interactive and are matched, so that the feed has an outstanding preventing and treating effect on the swine erysipelas and has the advantages of low side effect, high curing rate, short treating course, less possibility of relapse and the like.
Description
Technical field
The present invention relates to a boar food, particularly a kind of for feed preventing and treating brickpox and preparation method thereof.
Background technology
Brickpox is a kind of acute febrile infectious disease that bacillus rhusiopathiae suis causes, and its principal character is high heat, acute sepsis, skin rash block (subacute), chronic libman-Sack endocarditis and cutaneous necrosis and multiple non suppurative arthritis (chronic).Current Intensive Farm of Pig Raising is more rare, but controls completely not yet.This disease is in worldwide distribution.Bacillus rhusiopathiae suis is a kind of gram-positive bacteria, has the tendency significantly forming long filament.This bacterium is straight or micro-curved very thin dialister bacterium, and size is 0.2 ~ 0.4 micron × 0.8 ~ 2.5 micron.Bacterium in pathological material of disease, Dan, paired or one-tenth clump arrangement, general one-tenth clump existence in leucocyte, with in the internal membrane of heart wart-like lump of chronic disease pig in outmoded broth culture, many in long filament shape, sometimes very thin.The resistance of this bacterium to natural environments such as salted, fire is smoked, dry, corrupt and daylight is stronger.
In the liver, spleen of sick dead pig 4 DEG C 159 days, virulence is still powerful.The outdoor placement sick dead pig liver of 27 days, buried 1.5 meters of sick pig corpse of 231 days, 12.5% salt process also refrigerates in 4 DEG C of pork of 148 days, can be separated to bacillus rhusiopathiae suis.At general disinfectant, as very fast dead in 2% formalin, l% bleaching powder, 1% NaOH or 5% carbonic acid.More weak to the resistance of heat, broth culture is in 50 DEG C through 12 ~ 20 minutes, and 70 DEG C can be killed for 5 minutes.The acid resistance of this bacterium is comparatively strong, and the acidity in pig stomach can not kill it, therefore can enter enteron aisle through stomach.
The pathological change of brickpox is: at the bottom of (1) acute stomach and pyloric part vigorous film generation diffuse hemorrhage, and point is hemorrhage; Whole enteron aisle has Catarrhal in various degree or hemorrhagic inflammation; Splenomegaly, in typical sepsis spleen; Kidney extravasated blood, enlargement, have the title of " large purple kidney "; Lymph node is congested, enlargement, and tangent plane turns up, succulence, and the congested spot center of the subacute type of lungs extravasated blood, oedema (2) can because oedema compressing be in pale asphyxia.(3) chronic type 1. endocarditis: the endocarditic pathology bicuspid valve of defect shape can be seen and cauliflower-like proliferation appears in aorta petal at heart.2. arthritis: arthroncus, has serosity, fibrinous exudate to accumulate.
The cardinal symptom of brickpox is: short 1 day of incubation period of clinical symptoms, long 7 days.Acute: this kind of is common, to break out suddenly, acute process and height death is feature.Sick pig lassitude, high fever; Do not eat, vomit; Conjunctival congestion; Ight soil is stiff, with mucus.Piggy later stage diarrhea.Ear, neck, back of the body flush, blue.On one's deathbed front oxter, in stock, in abdomen, have irregular cerise patch, merge together after finger pressure fades.Normal dead in 3-4 days.Case fatality rate about 80%, the dead does not transfer rash block-type or chronic type to.When suckling pig and the piggy generation brickpox of just weaning, general sudden onset, performance nervous symptoms, twitch, bite the dust, the course of disease is no more than one day more.Subacute type (rash block-type): disease is comparatively light, especially chest side, back, neck to whole body occur that boundary is obvious to head, and circular, quadrangle, have the rash block of hotness, be commonly called as " diamond-skin disease ", finger pressure fades at health different parts a couple of days.Rash block gives prominence to skin 2-3 millimeter, size about to several centimetres, from several to dozens of not etc., forms brown crust after withered.Sick pig is thirsty, constipation, vomiting, fever.After rash block occurs, body temperature starts to decline, and patient's condition alleviates, through a few days so that more than ten days, and the rehabilitation voluntarily of sick pig.Also many sick pigs are had in pathogenic process, severity of symptoms and change septic and dead into.The course of disease is about 1-2 week.Chronic type: changed by acute or subacute type, also have primary, common are chornic arthritis, chronic endocarditis and cutaneous necrosis etc. several.Chornic arthritis type main manifestations is the inflammatory swelling of extremities joint (wrist, gambrel are the most common compared with knee, hip joint), and sick leg is stiff, pain.Later acute symptom disappears, and based on dysarthrasis, the broken row or the sleeping ground that present a limb or two limbs do not rise.Sick pig appetite is normal, but poor growth, have a delicate constitution, become thin.Course of disease several weeks or several months.Chronic endocarditis type main manifestations is become thin, anaemia, asthenia universalis, and happiness is sleeping, detests and walks about, force walking, then manner is slow, and whole body rocks.Auscultation heart has noise, palpitates quickly, hyperfunction, and cardiac arrhythmia, is short of breath.This kind of sick pig can not be cured, usually because cardioplegia falls down to the ground suddenly death.Exedens or cabbage sample excipuliform is gone to live in the household of one's in-laws on getting married natural disposition endocarditis.Cardiac arrhythmia, expiratory dyspnea, anaemia.Course of disease several weeks are to the several months.The brickpox of chronic type forms cutaneous necrosis sometimes.Often betide the portions such as the back of the body, shoulder, ear, hoof and tail.Local skin swelling, protuberance, necrosis, look black be, stiff, like leather.Be separated with its lower floor's cambium gradually, just as one deck crust.Necrotic area sometimes scope is very large, can account for whole skin of back; Sometimes can necrose at part auricular concha, tail, tip, each coffin.About come off through 2 ~ 3 months dead skin, leave over a slice and heal without hair, look light scar.If any scabies secondary infection, then the state of an illness is complicated, and the course of disease extends.
Current prevention and therapy brickpox medicine is PCs (Amoxicillin), cephalo-type (ceftiofur sodium).But the side effect of Western medicine is larger, and Western medicine only has obvious curative effect to single illness or a class illness when treating, and for the disease that some illnesss are more, curative effect is not too obvious, and usually need out a lot of Western medicine, price is higher; A lot of Chinese medicine is when treating brickpox mainly from antibacterial, anti-inflammatory, clearing heat and detoxicating, and the many-side such as ecchymose removing of invigorating blood circulation regulates body.Compared with antibiotic, non-merely antibacterial of Chinese medicine.Chinese medicine majority derives from natural plants, its complicated component, makes bacterium not easily produce drug resistance, also not easily causes medicament residue.The extensive concern of people prevented and treated the effect in the white scour of piglet and causing by Chinese medicine in recent years.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for feed preventing and treating brickpox and preparation method thereof, containing the Chinese medicine additive being used for the treatment of brickpox in feed, have evident in efficacy to the control of brickpox disease, side effect is low, cure rate is high, not easily the advantage such as recurrence.
In order to realize foregoing invention object, the invention provides the feed for preventing and treating brickpox, described feed comprises following raw material: barley, wheat, complex enzyme, yam flour, methionine, threonine, vitamin premix and Chinese medicine additive.
Described feed is made up of the raw material of following parts by weight: barley 40-60 weight portion, wheat 30-40 weight portion, complex enzyme 5-9 weight portion, yam flour 10-20 weight portion, methionine 2-4 weight portion, threonine 2-4 weight portion, vitamin premix 4-6 weight portion and Chinese medicine additive 4-9 weight portion.
Described feed is made up of the raw material of following parts by weight: barley 56 weight portion, wheat 33 weight portion, complex enzyme 7 weight portion, yam flour 15 weight portion, methionine 3 weight portion, threonine 3 weight portion, vitamin premix 5 weight portion and Chinese medicine additive 6 weight portion.
Described complex enzyme by dextranase, tie up plain enzyme, amylase forms; Vitamin premix main component is: vitamin A, vitamin D
3, vitamin E, vitamin K
3, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, folic acid, biotin, nicotinic acid, pantothenic acid, cottonseed protein, cornstarch, antioxidant and probiotics;
Described Chinese medicine additive is made up of following raw medicinal material: honeysuckle, fiber crops corruption, Spondias axillaris, root of Chinese trichosanthes, garlic, potato, ant, Da Lunmu, rheum officinale, glutinous rice, talcum, blackberry lily, subprostrate sophora, folium isatidis, lepidium seed, the root bark of tree peony, radix rehmanniae recen, radix scrophulariae, Radix Glycyrrhizae, almond, Chinese violet, catkin, duckweed, alum and dandelion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 10 ~ 20 weight portion, rotten 18 ~ 28 weight portions of fiber crops, Spondias axillaris 10 ~ 26 weight portion, root of Chinese trichosanthes 10 ~ 20 weight portion, garlic 10 ~ 20 weight portion, potato 10 ~ 15 weight portion, ant 10 ~ 20 weight portion, reach logical sequence wood 10 ~ 26 weight portion, rheum officinale 10 ~ 20 weight portion, glutinous rice 10 ~ 15 weight portion, talcum 10 ~ 26 weight portion, blackberry lily 10 ~ 25 weight portion, subprostrate sophora 10 ~ 15 weight portion, folium isatidis 10 ~ 20 weight portion, lepidium seed 10 ~ 20 weight portion, the root bark of tree peony 10 ~ 24 weight portion, radix rehmanniae recen 10 ~ 26 weight portion, radix scrophulariae 10 ~ 20 weight portion, Radix Glycyrrhizae 10 ~ 24 weight portion, almond 10 ~ 24 weight portion, Chinese violet 10 ~ 20 weight portion, catkin 10 ~ 20 weight portion, duckweed 10 ~ 15 weight portion, alum 10 ~ 15 weight portion and dandelion 10 ~ 20 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 12 ~ 17 weight portion, rotten 19 ~ 25 weight portions of fiber crops, Spondias axillaris 14 ~ 22 weight portion, root of Chinese trichosanthes 13 ~ 18 weight portion, garlic 12 ~ 17 weight portion, potato 10 ~ 15 weight portion, ant 15 ~ 20 weight portion, reach logical sequence wood 15 ~ 26 weight portion, rheum officinale 10 ~ 15 weight portion, glutinous rice 10 ~ 15 weight portion, talcum 10 ~ 18 weight portion, blackberry lily 10 ~ 21 weight portion, subprostrate sophora 10 ~ 15 weight portion, folium isatidis 10 ~ 17 weight portion, lepidium seed 10 ~ 16 weight portion, the root bark of tree peony 12 ~ 20 weight portion, radix rehmanniae recen 13 ~ 18 weight portion, radix scrophulariae 13 ~ 18 weight portion, Radix Glycyrrhizae 13 ~ 21 weight portion, almond 15 ~ 21 weight portion, Chinese violet 12 ~ 17 weight portion, catkin 12 ~ 18 weight portion, duckweed 13 ~ 15 weight portion, alum 13 ~ 15 weight portion and dandelion 13 ~ 17 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 15 weight portion, rotten 23 weight portions of fiber crops, Spondias axillaris 18 weight portion, root of Chinese trichosanthes 15 weight portion, garlic 15 weight portion, potato 13 weight portion, ant 17 weight portion, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portion, glutinous rice 13 weight portion, talcum 14 weight portion, blackberry lily 15 weight portion, subprostrate sophora 12 weight portion, folium isatidis 15 weight portion, lepidium seed 13 weight portion, the root bark of tree peony 16 weight portion, radix rehmanniae recen 15 weight portion, radix scrophulariae 16 weight portion, Radix Glycyrrhizae 17 weight portion, almond 18 weight portion, Chinese violet 15 weight portion, catkin 15 weight portion, duckweed 14 weight portion, alum 14 weight portion and dandelion 15 weight portion.
Described Chinese medicine additive also comprises following bulk drug: dried orange peel, husky, cloves and hawthorn.
Described Chinese medicine additive is made up of following bulk drug: honeysuckle 12 ~ 17 weight portion, rotten 19 ~ 25 weight portions of fiber crops, Spondias axillaris 14 ~ 22 weight portion, root of Chinese trichosanthes 13 ~ 18 weight portion, garlic 12 ~ 17 weight portion, potato 10 ~ 15 weight portion, ant 15 ~ 20 weight portion, reach logical sequence wood 15 ~ 26 weight portion, rheum officinale 10 ~ 15 weight portion, glutinous rice 10 ~ 15 weight portion, talcum 10 ~ 18 weight portion, blackberry lily 10 ~ 21 weight portion, subprostrate sophora 10 ~ 15 weight portion, folium isatidis 10 ~ 17 weight portion, lepidium seed 10 ~ 16 weight portion, the root bark of tree peony 12 ~ 20 weight portion, radix rehmanniae recen 13 ~ 18 weight portion, radix scrophulariae 13 ~ 18 weight portion, Radix Glycyrrhizae 13 ~ 21 weight portion, almond 15 ~ 21 weight portion, Chinese violet 12 ~ 17 weight portion, catkin 12 ~ 18 weight portion, duckweed 13 ~ 15 weight portion, alum 13 ~ 15 weight portion, dandelion 13 ~ 17 weight portion, dried orange peel 10 ~ 15 weight portion, husky 10 ~ 20 weight portions in ground, cloves 10 ~ 20 weight portion and hawthorn 10 ~ 20 weight portion.
Described Chinese medicine additive is made up of following bulk drug: honeysuckle 15 weight portion, rotten 23 weight portions of fiber crops, Spondias axillaris 18 weight portion, root of Chinese trichosanthes 15 weight portion, garlic 15 weight portion, potato 13 weight portion, ant 17 weight portion, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portion, glutinous rice 13 weight portion, talcum 14 weight portion, blackberry lily 15 weight portion, subprostrate sophora 12 weight portion, folium isatidis 15 weight portion, lepidium seed 13 weight portion, the root bark of tree peony 16 weight portion, radix rehmanniae recen 15 weight portion, radix scrophulariae 16 weight portion, Radix Glycyrrhizae 17 weight portion, almond 18 weight portion, Chinese violet 15 weight portion, catkin 15 weight portion, duckweed 14 weight portion, alum 14 weight portion, dandelion 15 weight portion, dried orange peel 13 weight portion, husky 15 weight portions in ground, cloves 15 weight portion and hawthorn 15 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, load in multi-function extractor, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, adds hot reflux and extracts for 1 hour ~ 3 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa ~ 0.6MPa, extracting liquid filtering is obtained the first filtered fluid and filter residue;
Second step, adding relative to the determining alcohol of first step mixture quality 1 ~ 3 times by the filter residue that the first step obtains is the ethanol of 80% ~ 90%, add hot reflux and extract for 0.5 hour ~ 1.5 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa ~ 0.6MPa, extracting liquid filtering is obtained the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains Chinese medicine additive powder.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of the feed for preventing and treating brickpox, described preparation method comprises the following steps:
(1) destruction step: take barley and wheat by weight percentage and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: be mixed into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 DEG C, makes its gelatinization degree reach more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying process: complex enzyme is sprayed to the surface of the pellet after fragmentation.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains the Chinese medicine additive being used for the treatment of brickpox, Chinese medicine additive with clearing heat-fire, Yin-nourishing and body fluid promoting, regulating blood condition of regulating the flow of vital energy, function of spleen and stomach regulating for primary treatment principle, with other feedstuff actings in conjunction, work in coordination, have evident in efficacy to brickpox control, side effect is low, the advantages such as cure rate is high, short treating period, not easily recurrence.
Detailed description of the invention
Chinese medicine, mainly by antibacterial, improves immunity of organisms, strengthens resistance against diseases, anti-inflammatory, mitigation symptoms, keeps gastrointestinal bacterial flora balance, gastrointestinal peristalsis inhibition, improves body blood physical and chemical index etc. and is used for treating brickpox.Theoretical according to traditional Chinese veterinary medicine, the morbidity of brickpox is relevant with many factors, and pig physique is weak, climate change, and diet problem etc. all can.Traditional Chinese veterinary medicine from deficiency of vital energy blood-head opinion it, ying-qi is empty and can not promote blood, therefore blood-head row and overflow channels and collaterals and occur extravasated blood spot in vain, or owing to heat being hindered body fluid, causes body fluid exhausted, and Jin Dynasty doctor Liu Wansu think: the kidney being a water ZANG-organ, and void is then hot, actually cold.The heart is that fire is dirty, by the restriction of kidney water, therefore advocates with the therapeutic rules of foster kidney watery diarrhea internal heat.Supporting kidney water is effect a permanent cure, and purge the sthenic heart-fire takes stopgap measures." etiology based on plain questions ": " elimnation for excess and tonification for deficiency, flat." brickpox mainly uses heat-clearing and fire-clearing drug, the more important thing is and reuse Yin-nourishing and body fluid promoting medicine.Qi and blood is obstructed, and all kinds of diseases and ailments are raw, stagnation of QI and blood may bring about pain, and during brickpox, ying-qi is weak, can not promote blood, and warm blood is gone outside channels and collaterals in vain, therefore produces blood cake rash.Therefore regulating blood condition of regulating the flow of vital energy treated by brickpox, ecchymose removing promoting eruption.By impelling QI-blood circulation, to make in body various nutritional labeling in vivo gradually to best configuration.The spleen being the foundation of acquired constitution, spleen be dirty in mother, taste, as tree root, do not have the biochemical action of spleen, allly dirtyly lose nutrition, and life cannot exist, and stomach, for receiving Gu Zhihai, does not have the effect of stomach, and spleen cannot carry out biochemical transporting, so be also noted that function of spleen and stomach regulating.
According to above-mentioned principle, the present invention with clearing heat-fire, Yin-nourishing and body fluid promoting, regulating blood condition of regulating the flow of vital energy, function of spleen and stomach regulating for primary treatment principle, provide a kind of feed containing Chinese medicine additive for preventing and treating brickpox, Chinese medicine additive comprises following raw medicinal material: honeysuckle, fiber crops corruption, Spondias axillaris, root of Chinese trichosanthes, garlic, potato, ant, Da Lunmu, rheum officinale, glutinous rice, talcum, blackberry lily, subprostrate sophora, folium isatidis, lepidium seed, the root bark of tree peony, radix rehmanniae recen, radix scrophulariae, Radix Glycyrrhizae, almond, Chinese violet, catkin, duckweed, alum and dandelion.
Fang Zhong, the pharmacology of each bulk drug is as follows:
Honeysuckle: taste is sweet, cold in nature, enters the heart, lung, stomach, large intestine channel, has clearing heat and detoxicating effect, doublely can remove heat from the blood and relieve diarrhea, and is mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is comparatively contained, or when warm disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of heat evil; The malicious diarrhea of heat, the lower blood of stool; Heat temperature is demonstrate,proved; The sore carbuncle that hot poison gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has good antipyretic effect, has antiinflammatory action, can promote leukocytic phagocytic function, have stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria.
Fiber crops are rotten: sharp stomach, relieving heat toxin, grows beneficial marrow, the most sharp old man.Profit flesh, laxation, removing toxic substances.
Spondias axillaris: taste is sweet; Acid; Property is put down.Return spleen; Liver Channel.Function cures mainly: the promoting flow of qi and blood circulation; Mental-tranquilization; Disappear long-pending; Removing toxic substances.Main qi depression to blood stasis; Pectoralgia; Palpitation; Neurasthenia; Insomnia; Bronchitis; Eat stagnant abdomen full; Diarrhoea; Hernia; Burn and scald.
Root of Chinese trichosanthes: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing heat and promoting fluid, detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, interior heat is quenched one's thirst, sore swollen toxin." detailed outline ": radices trichosanthis, sweet and slightly bitter taste acid, acid can be promoted the production of body fluid, therefore profit of quenching the thirst is withered, and fire falls in micro-hardship, does not sweetly injure one's stomach, and former times people only says its bitter cold, like deeply not examining." book on Chinese herbal medicine converge with speech ": root of Chinese trichosanthes, it is hot and suffocating to move back the five internal organs, and as internal heat is contained and dry tongue and mouth, lung-fire is contained and the swollen larynx numbness of pharynx, and spleen fire is contained and dispute tooth swells, and convulsive seizure due to phlegm-fire is contained and cough is not peaceful.Walk note if the side of body of irascibility is swollen, the hectic fever due to yin dysphoria with smothery sensation of kidney fire, or ulcer is not burst, and hot poison does not fall apart, or five subcutaneous ulcer yellow skin and eyes, and if if the pouring of little water is puckery, be all intimately caused by pent-up, convulsive seizure due to phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling polydipsia from blood medicine, is control thirsty key medicine also.
Garlic: warm in nature, taste is pungent flat; Enter spleen, stomach, lung channel.Removing toxic substances desinsection, swelling and pain relieving, antidiarrheal stops dysentery, controls lung, expelling parasite, also has warm spleen to warm up stomach in addition.Control swollen ulcer drug, white bald tinea sore, dysentery is had loose bowels, tuberculosis pertussis, roundworm pinworm, eating accumulation, coldness and pain in the epigastrium, oedema turgor, and promoting the circulation of qi disappears long-pending, and desinsection detoxifies.To swell sore for flu, bacillary dysentery, amoebic dysentery, enteritis, eating accumulation, carbuncle.Strong disinfecting: in garlic, sulfur-containing compound has strong antibacterial and anti-inflammation functions, all has suppression and killing action to multiple coccus, bacillus, fungi and virus etc., is the one that in the natural plants found at present, antibacterial action is the strongest.Anti-curing oncoma and cancer: the elements such as the germanium in garlic and selenium can the growth of inhibition tumor cell and cancer cell, and experiment finds, the crowd that cancer incidence is minimum is exactly the crowd that in blood, selenium content is the highest.National Cancer tissue is thought, in the plant of the anticancer potentiality of whole world most, what rank first is garlic.Toxin-expelling intestine-cleaning, prevention of intestinal gastric disease: garlic can effectively suppress and kill the bacterial viruses such as the helicobacter pylori causing gastrointestinal disease, removes stomach noxious material, stimulating gastrointestinal mucous membrane, promotes appetite, accelerates digestion.Reduce blood sugar, prevention diabetes: garlic can promote the secretion of insulin, increase histocyte to the absorption of glucose, improve human glucose tolerance, blood sugar level in rapid reduction body, and the various germs because of infection-induced diabetes can be killed, thus effective prevention and therapy diabetes.Control cardiovascular and cerebrovascular disease: garlic can prevent the fat deposition in cardiovascular and cerebrovascular, the metabolism of induced tissue fat inside, remarkable increase FA, reduces cholesterol, suppresses hematoblastic gathering, reduce PC, increase arteriolar expansion ratio, impel vasodilation, regulate blood pressure, increase the permeability of blood vessel, thus suppress formation and the prevention of arterial sclerosis of thrombus.Eat 2 ~ 3 lobe garlics every day, be the preferably the most easy way of step-down, garlic can help the right quantity of a kind of enzyme in holder and avoid occurring hypertension.
Potato: taste is sweet; Property is put down.Function cures mainly: in strong with stomach; Removing toxicity for detumescence.Main stomachache; Zha rib; Carbuncle swells; Eczema; Scald.
Ant: taste is salty; Acid; Property is put down.Return liver; Kidney channel.Function cures mainly: tonifying kidney and benefiting sperm; Clearing and activating the channels and collaterals; Removing toxicity for detumescence.Main dizzy tinnitus of suffering from a deficiency of the kidney; Insomnia and dreamful sleep; Impotence and seminal emission; Arthralgia due to wind-dampness; Hemiplegia 6; Numb in every limb; Erythematosus lupus; Chorionitis; Dermatomyositis; Carbuncle swells furunculosis; Venomous snake bite.
Reach logical sequence wood: acid; Pungent; Micro-hardship; Tepor.Function cures mainly: detumescence of dispeling the wind; Blood stasis removing analgesic.Main traumatic injury; Treating rheumatic ostealgia; Stomach and intestine angina; Cellulitis; Abscess; Stomatitis.
Rheum officinale: cure mainly real hot constipation; The thermojunction feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhoea; Oedema abdomen is full; Difficult urination; Hot eyes; Abscess of throat; Aphthae; Gastropyretic vomiting; Spit blood; Spitting of blood; Bleeding from five sense organs or subcutaneous tissue; Have blood in stool; Hematuria; Store blood; Through closing; The stagnant stomachache of the stasis of blood in postpartum; A lump in the abdomen causing distension and pain; Traumatic injury; The malicious large carbuncle of heat; Erysipelas; Scald.
Glutinous rice: sweet, temperature.Cure mainly tonifying middle-Jiao and Qi, controlling quenches one's thirst urinates many, and spontaneous perspiration, just lets out.Few for insufficiency of the spleen food, weak loose stool, hysteria of womam.Immunosuppressive action: the alcohol extract of date with every day 100 mg to rat oral gavage, display date has same immunosuppressive action with imuran, can suppress the generation of antibody to atopic diseases.Date alcohol extract may have inhibitory action to rat reactive antibody, and does not produce inhibitory action to non-reacted antibody.The two glucoside A of flavones in date, pharmacological evaluation proves have calmness, hypnosis and hypotensive effect, and date has the effect increasing cAMP in white blood cell.Date decoction can reduce the damage of CCl4 to liver.
Talcum: sweet, light, cold.Return bladder, lung, stomach warp.Function cures mainly: inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore.Drench for heat, urolithiasis, urinates hot puckery pain, summer-heat and damp polydipsia, damp and hot watery diarrhea; Control eczema outward, wet sore, prickly heat.
Blackberry lily: bitter, cold in nature, return lung, Liver Channel, have clearing heat and detoxicating, the effect of clear phlegm relieve sore throat, for the malicious convulsive seizure due to phlegm-fire pent-up of heat, abscess of throat, accumulation and obstruction of sputum, the cards such as cough and asthma, blackberry lily is commonly used to the disease for the treatment of respiratory tract, Chang Zuowei main ingredient in the compound of antiviral property breathing problem.Osajin in blackberry lily and triterpene substance are its main antiviral ingredients.What in current blackberry lily, isoflavone like substance had been reported has 30 multiple compounds.Osajin composition has anti-inflammatory, scavenging free radicals, the developing of pneumonia caused by the effect such as antibacterial, antiviral and anti-oxidant, and reduces inflammation, and has delayed-action to herpesviral I cytopathogenic effect.According to relevant report, the triterpenoid saponin constituents in blackberry lily has the generation strengthening Cellular Immunity, enhancing antibody and complement, regulates the effects such as cell factor.
Subprostrate sophora: bitter, cold; Poisonous.Attach to the lung and stomach meridians.Function cures mainly: clearing heat and detoxicating, detumescence relieve sore throat.Pent up for fiery poison, abscess of throat, gingivitis.
Folium isatidis: be mainly used in heat poison and send out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.This medicine extensive use clinically in recent years, controls except above-mentioned all diseases except available, can be used for again the strongly fragrant lung of phlegm heat, Huang of coughing up phlegm is thick; Especially be usually used in popular second encephalitis, both can be applied to prevention by single, and radix bupleuri, honeysuckle flower, the capsule of weeping forsythia, Radix Isatidis, radix scrophulariae, radix rehmanniae recen etc. can be coordinated again, can removing summer-heat gas divide, the heat of seek point is malicious, availablely control various encephalitis, and comparatively suitable with partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, larynx numbness, erysipelas." " Lan Yezhi separates Chinese blister beetle, Yuan green grass or young crops, tree of heaven chicken, cinnabar, arsenolite poison." " book on Chinese herbal medicine is just ": " control the hot poison of pestilence to go mad, wind-heat macula, large carbuncle swells and ache, relieving thirst and restlessness, only nosebleed epistaxis, haematemesis, kills infantile malnutrition due to digestive disturbances or intestinalparasites erosion, metal-inflicted wound curare.Allly to hold concurrently malicious person with heat, all should smash juice and use it by blue leaf.”
Lepidium seed: pungent; Bitter; Cold.Return lung channel; The heart channel of Hang-Shaoyin; Liver Channel; Stomach warp; Urinary bladder channel.Function: purging the lung of pathogenic fire sending down abnormally ascending; Eliminating phlegm and relieving asthma; Inducing diuresis for removing edema; Let out by heresy.Cure mainly: sputum stops up the dyspnea and cough with excessive sputum of lung; Lung carbuncle; Oedema; Chest abdomen ponding; Difficult urination; Chronic cor pulmonale; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
The root bark of tree peony: Compendium of Material Medica: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of moutan bark has suppression Platelet; Paeonol has the effects such as central inhibitory action and antiatherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolysis.
Radix rehmanniae recen: there is anti-inflammatory, anti-allergic effects.Glutinous rehmannia decoction gavage has obvious antagonism to big white mouse formaldehyde arthritis and albumen arthritis, and the increase of capillary permeability that the granuloma that turpentine oil hypodermic injection can be suppressed to cause and histamine cause. Rehmannia glutinosa Libosch Water extract has obvious inhibitory action to the mouse peritoneum inflammation that vasopermeability increases and acetic acid causes that histamine causes, also have antiinflammatory action to egg white induced Acute inflammation, the alcohol of glutinous rehmannia and ether extract are then without antiinflammatory action.Have antifungic action, the growth of Rehmannia glutinosa Libosch Water preserved material to multiple fungies such as trichophyton mentagrophytes, gypsum sample microspore tinea bacterium, ulotrichy microspore tinea bacterium and Du's big belly microspore tinea bacterium difficult to understand has inhibitory action.There is antagonism dexamethasone to the inhibitory action of Pituitary Adrenalcortical system, and the synthesis of cortex hormone of aadrenaline can be promoted.
Radix scrophulariae: there is antibacterial action.In vitro, radix scrophulariae has inhibitory action to trichophyton mentagrophytes, acrothesium floccosum and ulotrichy microspore tinea bacterium.Radix scrophulariae water logging agent (1:3) also has inhibitory action to Austria Du big belly microspore tinea bacterium in vitro.Experiment shows: the inhibitory effect of radix scrophulariae leaf is stronger than root, wherein particularly evident to staphylococcus aureus.
Radix Glycyrrhizae: property is put down, and taste is sweet, returns 12 warps.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolysis so that the pharmacological action such as anticancer, Radix Glycyrrhizae has reducing blood lipid, oxidation resistant effect.
Almond: bitter, tepor.Relieving cough and asthma, relax bowel.Antibechic, antiasthmatic effect, for cough and asthma.This product master enters lung channel.Bitter can fall, and holds concurrently and dredge the property opened of profit, falls the merit that has a surname's lung among lung qi concurrently and reaches relieving cough and asthma, for controlling the key medicine coughed and breathe heavily.Multiple cough illness card is can be used for card compatibility.Cough as chill and breathe heavily, compatibility Chinese ephedra, Radix Glycyrrhizae, with dispersing wind and cold, freeing lung and relieving asthma, i.e. Sanao tang.Cough due to wind-heat evil, compatibility mulberry leaf, chrysanthemum, with loose wind-heat, the cough-relieving of a surname's lung, as Sang Ju Yin.Cough caused by dryness-heat, compatibility mulberry leaf, the bulb of fritillary, the root of straight ladybell, with clearing away the lungheat and moisturizing cough-relieving, as sangxing decoction.Lung heat is coughed and is breathed heavily, and compatibility gypsum etc. expels the heat-evil with clearing lung-heat, freeings lung and relieving asthma, as Ma Xing Shi Gan Tang.To the effect of digestive system, gas under almond bitter, and be rich in fat oil.Fat oil can improve the lubrication of intestinal contents to mucous membrane, therefore almond has the function relaxed bowel.Anti-inflammatory, analgesic activity, amarogentin decomposes the benzaldehyde quiet styrax condensing enzyme effect produced and generates styrax.Styrax has analgesic activity, and therefore the domestic people of having can remove the misery of patient with semen armeniacae amarae treatment advanced liver cancer, and even not needing of having takes anodyne.Antitumor action, about the research of almond antitumor machanism mainly contains following several respects: 1. a part of scholar thinks that, containing a large amount of beta-glucosidase in cancer cell, this enzyme can be hydrolyzed amarogentin and produce hydrogen cyanide (HCN), benzaldehyde and glucose.Generate enzyme because cancer cell lacks sulphur nitrile, this enzyme has the detoxication to HCN, makes the sulphur nitrile compound that HCN becomes nontoxic, and normal cell lacks beta-glucosidase and generates enzyme containing a large amount of sulphur nitriles.According to this theory, amarogentin selectively should be able to kill cancer cell, and almost harmless to normal cell.2. the transparent sample that amarogentin can help body endotrypsin to digest cancer cell sticks protein film, makes the more accessible cancer cell of leucocyte in body, and engulfs cancer cell.3. someone finds that similar NaSCN and NaOCN of amarogentin can affect thymidine and enter liver tumor cell DNA and tumour cell to phosphate and amino acid whose absorption.Hypoglycemic activity, amarogentin has the effect of the diabetes that control causes because of antineoplastic alloxan.Adopt alloxan to bring out mouse hyperglycaemia method to prove, survey blood sugar after lumbar injection 3g/kg amarogentin 48h in advance, result shows that amarogentin can suppress the blood sugar caused by alloxan to raise specifically, and action intensity is relevant with the concentration of amarogentin in blood.Effect for reducing blood fat, clinical report, jordan almond obviously can reduce the blood lipid level of hyperlipemic patients, Spiller(1990) think in almond monounsaturated fatty acids and contribute to and reduce the blood fat that patient slightly raises, and without the need to strict dietary restriction.Beautification function, theoretical according to lung associating with skin and hair, can control from a surname's lung method opinion some disease of skin clinically, compatibility eats almond, often obtains prompt effect.Modern study proves, fat oil contained in semen armeniacae amarae can make keratoderma soften, thus reaches the effect of beauty treatment.For the dry constipation of intestines, this product contains grease and matter profit, bitter and lower gas, therefore can relax bowel.The Chang Peiwu seed of Oriental arborvitae, brush-cherry seed are equal to use, as the wuren pills of Effective Formulas Tested by Physicians for Generations.
Chinese violet: bitter, cold. enter the heart, Liver Channel.Function cures mainly: clearing heat and promoting diuresis, removing toxicity for detumescence.Control furunculosis, carbuncle swells, scrofula, jaundice, dysentery, diarrhoea, hot eyes, larynx numbness, venomous snake bite.
Catkin: bitter; Cool in nature.Function cures mainly: cooling blood and hemostasis; Removing toxicity for eliminating carbuncles.Main haematemesis; Traumatic bleeding; Ulcer; Dislike sore.
Duckweed: pungent, cold.Return lung channel.Function cures mainly: dispelling wind-heat, promoting eruption, diuresis.For measles without adequate eruption, rubella itch, oedema oliguria.
Alum: nature and flavor are sour and astringent, cold, poisonous.Therefore have antibacterial action, astriction etc., can be used as Chinese medicine.Alum has another name called alum, is the refinement product of alunite.Alum sour-puckery flavor cold in nature, has stronger astriction, and the traditional Chinese medical science thinks that alum has removing toxic substances desinsection, and eliminating dampness is antipruritic, hemostasis antidiarrheal, effect of heat-clearing dissolving phlegm.Research in recent years confirms, alum also has the effects such as antibacterial, anti-Trichomonas vaginalis.Antibacterial action alum has inhibitory action to multiple Grain-negative, positive cocci and bacillus; Stronger bacteriostasis is had to common pyogenic baeceria. experiment shows: alum has inhibitory action (test tube method) to staphylococcus aureus, proteus. there is inhibitory action (paper dish, flat band method) to Escherichia coli, Pseudomonas aeruginosa, bacillus anthracis, Fu Shi and shigella, typhoid bacillus and paratyphoid A bacillus, proteus and staphylococcus etc.; The strongest to viridans streptococci, hemolytic streptococcus, pneumococcus, corynebacterium diphtheriae effect, ox type Brucella, Bordetella pertussis, meningococcus effect being taken second place, to Bacillus influenzae without effect (paper disk method). high concentration alum steep also has inhibitory action to human-like (H37RV) and bacillus tuberculosis bovis. and effective to the charrin's disease controlling burn wound with 0.75% alumen suspension clinically.
Dandelion: the effect with resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus in vitro, also has certain bactericidal action to Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis.Dandelion extract (1:400) can suppress tulase in vitro.Dandelion water decoction (1:80) can delay ECHO11 viral cytopathic.Taraxol extract 31mg/kg can kill Leptospira.Water logging agent has inhibitory action to various skin fungi.Decoction, to Oral Administration in Rats, absorbs good, can keep certain antibacterial action in urine.Also have protect the liver, the effect of cholagogic, by dandelion decoction gavage or with Dandelion Injectable Solution injection, the glutamic-pyruvic transaminase caused carbon tetrachloride raises obvious inhibitory action; Significantly can alleviate the Histological change that carbon tetrachloride hepatic injury causes.Have report to point out, dandelion has choleretic effect in animals.Herba Taraxaci liquid gavage can make gallbladder contraction, and oddi's sphincter relaxes, and is conducive to bile and enters in intestines.Clinically to chronic gallbladder spasmolytic and calculosis effective.Also there is immunologic function, dandelion decoction can significantly improve PBLC blast transformation rate in vitro, Taraxacum Polysaccharides significantly can strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice foot pad delayed allergy intensity, and have administration time more effective feature more backward, the administration on the 11st ~ 20th namely after antigenic stimulus or 2 ~ 20 the next day administration have obvious effect.Taraxacum Polysaccharides lumbar injection significantly can strengthen the CDCC of mouse antibodies dependence macrophage.
Chinese medicine additive of the present invention also comprises: dried orange peel, husky, cloves and hawthorn.
Dried orange peel: warm in nature, taste is pungent, bitter; Return spleen, lung channel, for diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, gather around the diseases such as stagnant, chest diaphragm ruffian full and the taste stagnation of the circulation of vital energy, abdominal fullness and distention for lung qi, for damp retention in middle-jiao, gastral cavity abdomen ruffian is swollen, have loose bowels in loose stool, and the disease such as many coughs of phlegm.Orange peel dispelling dampness with bitter and warm-natured drugs and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Being good at again eliminating dampness and eliminating phlegm, stopping up the conventional key medicine of lung, the many coughs of phlegm for controlling wet phlegm, reduce for insufficiency of the spleen diet, indigestion, and the disease such as n and V.This product eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizings, indigestion, stool diarrhea, often and the fit applications such as ginseng, the bighead atractylodes rhizome, Poria cocos.Because it can invigorating the spleen, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, orange peel again can with in, stomach Qi rising, n and V can be controlled.
Ground is husky: property is put down, and taste is sweet.Function cures mainly: invigorating the spleen, moistening lung.
Cloves: Wen Zhong, warm kidney, fall inverse.Cure mainly: control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addiction, hernia, ringworm.Meridian distribution of property and flavor: pungent, temperature." Kaibao Bencao ": " taste is pungent, temperature, nontoxic." enter stomach, spleen, kidney channel." Japan hanako materia medica ": control implication, gastric disorder causing nausea, treats kidney qi, up-rushing gas syndrome, cloudy pain, establishing-Yang, and warm waist knee, kill wine poison, disappear Xuan addiction, except cold labor.
Hawthorn: section is dried, put in pot large stir-fry of useing force and be degree to outside Jiao's brown, inner yellowish-brown, spray clear water, taking-up is dried, and is charred FRUCTUS CRATAEGI.There is appetite-stimulating indigestion-relieving, change effect of stagnant long-pending, the promoting blood circulation to remove blood stasis of disappearing, promoting the circulation of qi of reducing phlegm, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral hawthorn can increase digestive ferment, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by abdominal fullness and distention, belch, do not feel like eating, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, hawthorn has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglycerides, atherosclerosis, but also can diastole coronary artery, increases myocardial contractive power, to anti-arrhythmia.Therefore, be conducive to preventing and treating hypertension, high fat of blood, artery sclerosis and coronary heart disease.
Embodiment 1 feed 1
Embodiments provide a kind of feed being used for the treatment of brickpox, feed is made up of the raw material of following parts by weight: barley 48 weight portion, wheat 40 weight portion, complex enzyme 9 weight portion, yam flour 13 weight portion, methionine 4 weight portion, threonine 4 weight portion, vitamin premix 5 weight portion and Chinese medicine additive 9 weight portion.
Wherein, complex enzyme by ratio of weight and number be 1:1:1 dextranase, tie up plain enzyme, amylase forms, vitamin premix main component is: retinol1 800IU/kg, vitamin D
3270 IU/kg, vitamin E 89 IU/kg, vitamin K
30.5mg/kg, Cobastab
12.8mg/kg, Cobastab
24mg/kg, Cobastab
62mg/kg, Cobastab
1221 μ g/kg, folic acid 0.6mg/kg, biotin 0.4mg/kg, nicotinic acid 29mg/kg, pantothenic acid 21mg/kg, cottonseed protein 8mg/kg, cornstarch 11mg/kg, antioxidant 2mg/kg and probiotics 5mg/kg, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 15 weight portion, rotten 23 weight portions of fiber crops, Spondias axillaris 18 weight portion, root of Chinese trichosanthes 15 weight portion, garlic 15 weight portion, potato 13 weight portion, ant 17 weight portion, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portion, glutinous rice 13 weight portion, talcum 14 weight portion, blackberry lily 15 weight portion, subprostrate sophora 12 weight portion, folium isatidis 15 weight portion, lepidium seed 13 weight portion, the root bark of tree peony 16 weight portion, radix rehmanniae recen 15 weight portion, radix scrophulariae 16 weight portion, Radix Glycyrrhizae 17 weight portion, almond 18 weight portion, Chinese violet 15 weight portion, catkin 15 weight portion, duckweed 14 weight portion, alum 14 weight portion and dandelion 15 weight portion.
Wherein, the preparation method of Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, load in multi-function extractor, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 80%, adds hot reflux and extracts for 3 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa, extracting liquid filtering is obtained the first filtered fluid and filter residue;
Second step, adding relative to the determining alcohol of first step mixture quality 3 times by the filter residue that the first step obtains is the ethanol of 80%, adds hot reflux and extracts for 1.5 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa, extracting liquid filtering is obtained the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 170 DEG C, leaving air temp 60 DEG C, is ground into 400 orders subsequently, obtains Chinese medicine additive powder.
The feed of the embodiment of the present invention is obtained by following preparation method:
(1) destruction step: take barley and wheat by weight percentage and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: be mixed into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 DEG C, makes its gelatinization degree reach more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying process: complex enzyme is sprayed to the surface of the pellet after fragmentation.
Embodiment 2 feed 2
Embodiments providing a kind of feed for preventing and treating brickpox, being made up of the raw material of following parts by weight: barley 56 weight portion, wheat 33 weight portion, complex enzyme 7 weight portion, yam flour 15 weight portion, methionine 3 weight portion, threonine 3 weight portion, vitamin premix 5 weight portion and Chinese medicine additive 6 weight portion.
Wherein, complex enzyme by ratio of weight and number be 2:1:2 dextranase, tie up plain enzyme, amylase forms, vitamin premix main component is: retinol1 800IU/kg, vitamin D
3270 IU/kg, vitamin E 89 IU/kg, vitamin K
30.5mg/kg, Cobastab
12.8mg/kg, Cobastab
24mg/kg, Cobastab
62mg/kg, Cobastab
1221 μ g/kg, folic acid 0.6mg/kg, biotin 0.4mg/kg, nicotinic acid 29mg/kg, pantothenic acid 21mg/kg, cottonseed protein 8mg/kg, cornstarch 11mg/kg, antioxidant 2mg/kg and probiotics 5mg/kg, Chinese medicine additive is made up of following raw medicinal material: honeysuckle 15 weight portion, rotten 23 weight portions of fiber crops, Spondias axillaris 18 weight portion, root of Chinese trichosanthes 15 weight portion, garlic 15 weight portion, potato 13 weight portion, ant 17 weight portion, reach logical sequence wood 21 weight portions, rheum officinale 13 weight portion, glutinous rice 13 weight portion, talcum 14 weight portion, blackberry lily 15 weight portion, subprostrate sophora 12 weight portion, folium isatidis 15 weight portion, lepidium seed 13 weight portion, the root bark of tree peony 16 weight portion, radix rehmanniae recen 15 weight portion, radix scrophulariae 16 weight portion, Radix Glycyrrhizae 17 weight portion, almond 18 weight portion, Chinese violet 15 weight portion, catkin 15 weight portion, duckweed 14 weight portion, alum 14 weight portion, dandelion 15 weight portion, dried orange peel 13 weight portion, husky 15 weight portions in ground, cloves 15 weight portion and hawthorn 15 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, load in multi-function extractor, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, adds hot reflux and extracts for 2 hours, obtain extract, the steam pressure added in thermal reflow process is 0.5MPa, extracting liquid filtering is obtained the first filtered fluid and filter residue;
Second step, adding relative to the determining alcohol of first step mixture quality 2 times by the filter residue that the first step obtains is the ethanol of 85%, adds hot reflux and extracts for 1 hour, obtain extract, the steam pressure added in thermal reflow process is 0.5MPa, extracting liquid filtering is obtained the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into spray dryer dry, and ensure that EAT is at 180 DEG C, leaving air temp 70 DEG C, is ground into 300 orders subsequently, obtains Chinese medicine additive powder.
Toxicity test
1, acute toxicity test
Require to carry out prerun according to acute toxicity test, find that test medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get above-mentioned mouse 40, fasting can't help water after 12 hours, administration group and water control group is divided at random by body weight, often organize 20, administration group gives the liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the Chinese medicine additive prepared containing embodiment 1, gavage one day 2 times, make dosage in a day reach symphysis dose 192.0g/kg, water control group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, equal Continuous Observation seven days, the toxic reaction that record may occur and death condition, after administration, mouse outward appearance hair color light, behavioral activity is normal, pathologic neural reflex without exception occurs, in seven days, feed is good, and other Novel presentation is seen at end, changes of weight no significant difference and none animal dead compared with water control group, visually observe the main organs such as the heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, the test result of result as embodiment 1 Chinese medicine additive is identical.
Long term toxicity test
The Chinese medicine additive aqueous solution of the embodiment of the present invention 1 gavages 16 weeks (1.0ml/100g body weight to mouse continuously by 10.78,20.35 and 33.48g crude drug/kg, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of Chinese medicine additive to mouse of the embodiment of the present invention 1 all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine additive of the present invention is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.Use the Chinese medicine additive of the embodiment of the present invention 2 to carry out above-mentioned test to mouse, the test result of result as embodiment 1 Chinese medicine additive is identical.
Clinical testing
1.1 for examination material
1.1.1 for examination animal
In pig farm, Weifang City of Shandong Province, random choose 3 monthly age sodium selenite 150.
1.1.2 strains tested
The individual raiser of Shandong Province pig, find the piglet phenomena of mortality, other piglet lassitudes, high fever, does not eat, vomiting, conjunctival congestion, and ight soil is stiff, with mucus, in oxter, stock, has irregular cerise patch in abdomen, merges together after finger pressure fades.After being dissected by dead piglet, find at the bottom of stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal in various degree or hemorrhagic inflammation, and splenomegaly, in typical sepsis spleen.By pathological material of disease sterile samplings such as the livers of dead pig, inoculation blood agar medium, cultivates 24h in 37 DEG C of constant temperature are wet, observes colonial morphology, then select suspicious bacterium colony and carry out pure culture.The tiny bacillus of the visible Gram-positive of microscopy, very thin shaft-like person is in the majority, easily forms long filament shape, the blunt circle in two ends, and methylene blue dyeing is the club shape of color depth, has long and bending thread thalline.The erysipelas bacillus be separated to is attacked malicious two suckling pig, after 24 hours, finds brickpox symptom, determine that dead piglet is that brickpox is lethal.Using the bacterial strain of separation as strains tested.
1.1.3 for reagent product
The feed 1 of embodiment 1; The feed 2 of embodiment 2; Conventional medicament: Amoxicillin+qingkailing injections.
1.2 test method
1.2.1 inoculation test
By the erysipelas bacterial strain cultivated respectively intravenous injection 134 for examination piglet, infects and all occurs brickpox symptom after one day, selection wherein 120 ill piglets as experiment pig.
1.2.2 grouping is tested
120 ill piglets are divided into three groups at random, often organize 40, i.e. embodiment group 1, embodiment group 2 and control group.
1.2.3 test method
Occur after infection that the piglet of swine erysipelas adopts diverse ways to treat respectively, wherein, embodiment group 1 uses the feed 1 of the embodiment of the present invention 1 to treat, and uses 4 days continuously; Embodiment group 2 uses the embodiment of the present invention 2 feed 2 to treat, and uses 4 days continuously; Control group uses Amoxicillin 2 grams/50 kg body weight+qingkailing injections 20 milliliters/50 kg body weight, once a day, is used in conjunction 4 days, uses conventional feed to feed.
1.2.4 observed and recorded
Clinical symptoms and the pathological change of each group of piglet is observed, the result for the treatment of after the rear death toll of record infection and treatment terminate after infection.
2 results
2.1 criterion of therapeutical effect
Cure: ill piglet spirit, appetite, body temperature, defecation all recover normal, the cerise patch in oxter, stock, in abdomen all disappears;
Effective: ill piglet spirit, appetite, body temperature, defecation all recover normal, the red patch in oxter, stock, in abdomen is clearly better;
Invalid: it is even dead that ill piglet symptom does not disappear or sb.'s illness took a turn for the worse.
Wherein, efficient for curing and effective percentage sum.
2.2 observed results are as shown in table 1.
The table 1 treatment results table of comparisons
| Group | Death toll (only) | Cure (only) | Effectively (only) | Invalid (only) | Efficient (%) |
| Embodiment group 1 | 1 | 30 | 8 | 2 | 95.0% |
| Embodiment group 2 | 0 | 32 | 7 | 1 | 97.5% |
| Control group | 3 | 20 | 12 | 8 | 80.0% |
Data from table 1: compared with control group, the treatment of feed to brickpox of the embodiment of the present invention 1 and embodiment 2 has evident in efficacy, and side effect is low, the advantage that treated effect is high; Find in long-term observation subsequently, embodiment group 1 and embodiment group 2 piglet of curing the again incidence of disease is starkly lower than the piglet of control group.
2.3 infect rear symptom and cut open inspection result
After infection, the symptom of ill piglet is: lassitude, and high fever, does not eat, vomiting, conjunctival congestion, and ight soil is stiff, with mucus, in oxter, stock, has irregular cerise patch in abdomen, merges together after finger pressure fades.After being dissected by dead piglet, find at the bottom of stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal in various degree or hemorrhagic inflammation, and splenomegaly, in typical sepsis spleen.
Concrete case
Case 1
Two 3 monthly age piglet discovery lassitude that the Qin is domestic, do not eat, the phenomenon of high fever, vomiting and conjunctival congestion is there is after one day, occur there is cerise patch in oxter and abdomen two days later, merge after finger pressure fades together, be diagnosed as brickpox, use the forage feed of the embodiment of the present invention 1, feed in a conventional manner, use 3 days continuously, two pig all recovers normal.
Case 2
27 suckling pigs on certain pig farm, there are the phenomena of mortality in 1 piglet, in dead front oxter, stock, has irregular cerise patch in abdomen, merge together after finger pressure fades, after being dissected by dead piglet, find at the bottom of stomach and pyloric part film generation diffuse hemorrhage, point is hemorrhage; Whole enteron aisle has Catarrhal in various degree or hemorrhagic inflammation, and splenomegaly, in typical sepsis spleen, other piglets all have poor appetite, spirit is low, and the symptom of cerise patch appears in oxter, is diagnosed as brickpox, use the forage feed of the embodiment of the present invention 2, feed according to normal feed mode, use 3 days continuously, 23 piglets all recover normal, continual cure 2 days, other 4 piglets all recover normal.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (5)
1. for preventing and treating the feed of brickpox, it is characterized in that, described feed is made up of the raw material of following parts by weight: barley 40-60 weight portion, wheat 30-40 weight portion, complex enzyme 5-9 weight portion, yam flour 10-20 weight portion, methionine 2-4 weight portion, threonine 2-4 weight portion, vitamin premix 4-6 weight portion and Chinese medicine additive 4-9 weight portion;
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 10 ~ 20 weight portion, rotten 18 ~ 28 weight portions of fiber crops, Spondias axillaris 10 ~ 26 weight portion, root of Chinese trichosanthes 10 ~ 20 weight portion, garlic 10 ~ 20 weight portion, potato 10 ~ 15 weight portion, ant 10 ~ 20 weight portion, reach logical sequence wood 10 ~ 26 weight portion, rheum officinale 10 ~ 20 weight portion, glutinous rice 10 ~ 15 weight portion, talcum 10 ~ 26 weight portion, blackberry lily 10 ~ 25 weight portion, subprostrate sophora 10 ~ 15 weight portion, folium isatidis 10 ~ 20 weight portion, lepidium seed 10 ~ 20 weight portion, the root bark of tree peony 10 ~ 24 weight portion, radix rehmanniae recen 10 ~ 26 weight portion, radix scrophulariae 10 ~ 20 weight portion, Radix Glycyrrhizae 10 ~ 24 weight portion, almond 10 ~ 24 weight portion, Chinese violet 10 ~ 20 weight portion, catkin 10 ~ 20 weight portion, duckweed 10 ~ 15 weight portion, alum 10 ~ 15 weight portion and dandelion 10 ~ 20 weight portion.
2. the feed for preventing and treating brickpox according to claim 1, it is characterized in that, described feed is made up of the raw material of following parts by weight: barley 56 weight portion, wheat 33 weight portion, complex enzyme 7 weight portion, yam flour 15 weight portion, methionine 3 weight portion, threonine 3 weight portion, vitamin premix 5 weight portion and Chinese medicine additive 6 weight portion.
3. the feed for preventing and treating brickpox according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: honeysuckle 12 ~ 17 weight portion, rotten 19 ~ 25 weight portions of fiber crops, Spondias axillaris 14 ~ 22 weight portion, root of Chinese trichosanthes 13 ~ 18 weight portion, garlic 12 ~ 17 weight portion, potato 10 ~ 15 weight portion, ant 15 ~ 20 weight portion, reach logical sequence wood 15 ~ 26 weight portion, rheum officinale 10 ~ 15 weight portion, glutinous rice 10 ~ 15 weight portion, talcum 10 ~ 18 weight portion, blackberry lily 10 ~ 21 weight portion, subprostrate sophora 10 ~ 15 weight portion, folium isatidis 10 ~ 17 weight portion, lepidium seed 10 ~ 16 weight portion, the root bark of tree peony 12 ~ 20 weight portion, radix rehmanniae recen 13 ~ 18 weight portion, radix scrophulariae 13 ~ 18 weight portion, Radix Glycyrrhizae 13 ~ 21 weight portion, almond 15 ~ 21 weight portion, Chinese violet 12 ~ 17 weight portion, catkin 12 ~ 18 weight portion, duckweed 13 ~ 15 weight portion, alum 13 ~ 15 weight portion and dandelion 13 ~ 17 weight portion.
4. the feed for preventing and treating brickpox according to any one of claim 1-3, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, all bulk drugs are mixed in proportion, be ground into powder, load in multi-function extractor, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, adds hot reflux and extracts for 1 hour ~ 3 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa ~ 0.6MPa, extracting liquid filtering is obtained the first filtered fluid and filter residue;
Second step, adding relative to the determining alcohol of first step mixture quality 1 ~ 3 times by the filter residue that the first step obtains is the ethanol of 80% ~ 90%, add hot reflux and extract for 0.5 hour ~ 1.5 hours, obtain extract, the steam pressure added in thermal reflow process is 0.4MPa ~ 0.6MPa, extracting liquid filtering is obtained the second filtered fluid;
3rd step, the first filtered fluid and the second filtered fluid are merged, reduced pressure concentration is except desolventizing, obtain and get dry extract, dry cream is put into spray dryer dry, ensure that EAT is at 170 DEG C ~ 190 DEG C, leaving air temp 60 DEG C ~ 80 DEG C, is ground into 200 order ~ 400 orders subsequently, obtains Chinese medicine additive powder.
5. a preparation method for the feed for preventing and treating brickpox as described in any one of claim 1-4, it is characterized in that, described preparation method comprises the following steps:
(1) destruction step: take barley and wheat by weight percentage and drop into pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: be mixed into yam flour, methionine, threonine, vitamin premix and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 DEG C, makes its gelatinization degree reach more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again;
(5) spraying process: complex enzyme is sprayed to the surface of the pellet after fragmentation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310744843.8A CN103719552B (en) | 2013-12-30 | 2013-12-30 | Feed for preventing and treating swine erysipelas and preparation method for feed |
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| CN201310744843.8A CN103719552B (en) | 2013-12-30 | 2013-12-30 | Feed for preventing and treating swine erysipelas and preparation method for feed |
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| CN103719552A CN103719552A (en) | 2014-04-16 |
| CN103719552B true CN103719552B (en) | 2015-07-01 |
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| CN107048007A (en) * | 2017-02-09 | 2017-08-18 | 安徽菲扬农业科技有限公司 | A kind of feed of prevention brickpox |
| CN107259153A (en) * | 2017-07-25 | 2017-10-20 | 安徽华米生物科技有限公司 | It is a kind of to be used to prevent feed of brickpox and preparation method thereof |
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| CN101695342B (en) * | 2009-10-23 | 2012-01-11 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN102038098A (en) * | 2010-09-14 | 2011-05-04 | 周剑峰 | Feed additive for preventing and treating swine erysipelas |
| CN103416625B (en) * | 2013-08-05 | 2014-07-02 | 山东新希望六和集团有限公司 | Barley piglet feed and preparation method thereof |
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