CN103656315B - Medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof - Google Patents
Medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof, medicine comprises following raw medicinal material: Cortex Magnoliae Officinalis, Herba Veronicae, Oviductus Ranae, Semen Lepidii (Semen Descurainiae), Radix Scutellariae, Rhizoma Coptidis, Herba Mimosae Pudicae, Herba Swertiae davidi, Radix Rhodiolae, Caulis Bambusae In Taenia, Liquod Orzae Distillata, Rhizoma Phragmitis, Semen Raphani, Radix Rubi Parvifolii, Radix Zanthoxyli Spinifolii, Radix Aerio Fici Microcarpae, Radix Stephaniae Cepharanthae, Hui Bao, Castanea seguinii Dode (Involucrum Castaneae Seguinii) and Herba Thermopsis Lanceolatae.The invention has the beneficial effects as follows: medicine of the present invention with clearing away heat-fire, anti-inflammation, support lung YIN nourishing, relieving cough and asthma for Therapeutic Principle, the advantage that treatment porcine contagious pleuropneumonia good effect, instant effect, toxic and side effects are little, with low cost.
Description
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of porcine contagious pleuropneumonia and preparation method thereof.
Background technology
Pig transmissible pleuritis is a kind of respiratory infectious disease of the pig caused by pleuritis Actinobacillus, with pneumonia and pleuritis for characteristic pathological changes.This disease can cause the height dyspnea of pig, and acute sepsis and sudden death occur; After infecting, the growing-finishing pigs of survival is slow, and average daily gain and the price of deed decline, and resistance toly crosses boar and often become the potential source of infection because carrying disease germs.Pathogen is Actinobacillus pleuropneumoniae, is club shape, shaft-like, filamentous bacteria; Showing as pleomorphism, do not move, is Gram-positive amphimicrobian; Optimum growth temperature is 37 DEG C, growth scope 25 ~ 43 DEG C; Resistance is strong, conventional disinfectant and lowlyer to kill, and has certain resistance, can survive 7 ~ 10 days at 5 DEG C to low temperature.Pathogenic bacteria is mainly present in disease porcine respiratory.Winter and early spring are multiple season, pig all susceptibles of all ages and classes, sex, and with the most susceptible of 6 weeks ~ 3 monthly age piglet, and the pig morbidity of 4 ~ 5 monthly ages is dead more.The factor affecting the height of sickness rate and mortality rate is a lot, as abrupt change of climate, and improper ventilation, the flip-flop of feeding environment, dense husbandry and long-distance transport etc.With feeding and management condition and environmental condition improvement and reduce to some extent.
Porcine contagious pleuropneumonia incubation period is 1 ~ 7 day, wherein the most acutely shows as with acute pig, sick pig sudden onset, and body temperature is increased to 41.5 ~ 42 DEG C, does not eat food, and spirit is depressed, rapid breathing, sometimes laxativeness; Later stage dyspnea, presents and dehisces to loll, dog sitting posture, flows out foam sample secretions, be sometimes with color, palpitating speed from mouth and nose, and if mouth, nose, ear, limbs skin are mulberry, often dead in 2 days, the not aobvious symptom of indivedual pig is namely dead.Some pig may transfer to subacute and chronic, sick temperature of pig body 39 ~ 40 DEG C, loss of appetite or absolutely useless, and intermittent cough, condition of illness progressively relaxes.But, some chronic type or healing or the pig of inapparent infection, when environment changes such as other pathogenic infections (as pasteurellosis bacillus or mycoplasma etc.) or transports, all may make exacerbation of symptoms or transfer to acute.
The prevention of primary disease mainly will do pig house environment health well, prevents by chronic, the recessive pig of outer introducing and the pig that carries disease germs, once import health pig into, is difficult to remove.As introduced a fine variety, should isolate and carry out Serological testing, confirming as negative pig and just can introduce.
General choice drug is penicillin, chloromycetin and SMZ-SD-TMP methylisoxazole (sulfamethoxazole), or should coordinate the sodium bicarbonate (sodium bicarbonate) of equivalent during sulfamethoxazole for oral administration.Also can select long-acting terramycin, obtain meter Xian etc.The shortcoming of Western medicine is that side effect is relatively large, is not suitable for long-term taking, and be also not suitable for uses as health medicine more, and some medicines easily produce drug resistance or Drug resistance.And Chinese tradition Chinese herbal medicine is in the lipid metabolism of regulation and control Swine, control porcine contagious pleuropneumonia aspect has advantageous advantage, may be used for preventing and treating porcine contagious pleuropneumonia.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of porcine contagious pleuropneumonia, has the advantage that good effect, instant effect, toxic and side effects are little, with low cost.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of porcine contagious pleuropneumonia, wherein, described medicine comprises following raw medicinal material: Cortex Magnoliae Officinalis, Herba Veronicae, Oviductus Ranae, Semen Lepidii (Semen Descurainiae), Radix Scutellariae, Rhizoma Coptidis, Herba Mimosae Pudicae, Herba Swertiae davidi, Radix Rhodiolae, Caulis Bambusae In Taenia, Liquod Orzae Distillata, Rhizoma Phragmitis, Semen Raphani, Radix Rubi Parvifolii, Radix Zanthoxyli Spinifolii, Radix Aerio Fici Microcarpae, Radix Stephaniae Cepharanthae, Hui Bao, Castanea seguinii Dode (Involucrum Castaneae Seguinii) and Herba Thermopsis Lanceolatae.
Described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 20-30 weight portion, Herba Veronicae 15-25 weight portion, Oviductus Ranae 10-20 weight portion, Semen Lepidii (Semen Descurainiae) 10-20 weight portion, Radix Scutellariae 20-30 weight portion, Rhizoma Coptidis 20-30 weight portion, Herba Mimosae Pudicae 20-30 weight portion, Herba Swertiae davidi 10-30 weight portion, Radix Rhodiolae 10-20 weight portion, Caulis Bambusae In Taenia 10-30 weight portion, Liquod Orzae Distillata 20-30 weight portion, Rhizoma Phragmitis 10-20 weight portion, Semen Raphani 10-30 weight portion, Radix Rubi Parvifolii 10-20 weight portion, Radix Zanthoxyli Spinifolii 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Radix Stephaniae Cepharanthae 10-20 weight portion, ash bag 10-20 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 20-30 weight portion and Herba Thermopsis Lanceolatae 5-10 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 23-27 weight portion, Herba Veronicae 17-23 weight portion, Oviductus Ranae 13-17 weight portion, Semen Lepidii (Semen Descurainiae) 12-18 weight portion, Radix Scutellariae 23-27 weight portion, Rhizoma Coptidis 22-28 weight portion, Herba Mimosae Pudicae 23-28 weight portion, Herba Swertiae davidi 15-20 weight portion, Radix Rhodiolae 13-18 weight portion, Caulis Bambusae In Taenia 14-23 weight portion, Liquod Orzae Distillata 23-28 weight portion, Rhizoma Phragmitis 13-17 weight portion, Semen Raphani 15-26 weight portion, Radix Rubi Parvifolii 13-17 weight portion, Radix Zanthoxyli Spinifolii 13-17 weight portion, Radix Aerio Fici Microcarpae 12-18 weight portion, Radix Stephaniae Cepharanthae 13-18 weight portion, ash bag 13-15 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 23-29 weight portion and Herba Thermopsis Lanceolatae 5-8 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 19 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 26 weight portion, Herba Mimosae Pudicae 26 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 15 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 26 weight portion and Herba Thermopsis Lanceolatae 6 weight portion.
Described medicine also comprises: Rhizoma Dioscoreae, Fructus Chaenomelis, Massa Medicata Fermentata, Auricularia and Fructus Crataegi.
Described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 20-30 weight portion, Herba Veronicae 15-25 weight portion, Oviductus Ranae 10-20 weight portion, Semen Lepidii (Semen Descurainiae) 10-20 weight portion, Radix Scutellariae 20-30 weight portion, Rhizoma Coptidis 20-30 weight portion, Herba Mimosae Pudicae 20-30 weight portion, Herba Swertiae davidi 10-30 weight portion, Radix Rhodiolae 10-20 weight portion, Caulis Bambusae In Taenia 10-30 weight portion, Liquod Orzae Distillata 20-30 weight portion, Rhizoma Phragmitis 10-20 weight portion, Semen Raphani 10-30 weight portion, Radix Rubi Parvifolii 10-20 weight portion, Radix Zanthoxyli Spinifolii 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Radix Stephaniae Cepharanthae 10-20 weight portion, ash bag 10-20 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 20-30 weight portion, Herba Thermopsis Lanceolatae 5-10 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Fructus Chaenomelis 10-20 weight portion, Massa Medicata Fermentata 10-20 weight portion, Auricularia 10-20 weight portion and Fructus Crataegi 10-20 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 23-27 weight portion, Herba Veronicae 17-23 weight portion, Oviductus Ranae 13-17 weight portion, Semen Lepidii (Semen Descurainiae) 12-18 weight portion, Radix Scutellariae 23-27 weight portion, Rhizoma Coptidis 22-28 weight portion, Herba Mimosae Pudicae 23-28 weight portion, Herba Swertiae davidi 15-20 weight portion, Radix Rhodiolae 13-18 weight portion, Caulis Bambusae In Taenia 14-23 weight portion, Liquod Orzae Distillata 23-28 weight portion, Rhizoma Phragmitis 13-17 weight portion, Semen Raphani 15-26 weight portion, Radix Rubi Parvifolii 13-17 weight portion, Radix Zanthoxyli Spinifolii 13-17 weight portion, Radix Aerio Fici Microcarpae 12-18 weight portion, Radix Stephaniae Cepharanthae 13-18 weight portion, ash bag 13-15 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 23-29 weight portion, Herba Thermopsis Lanceolatae 5-8 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Fructus Chaenomelis 15-20 weight portion, Massa Medicata Fermentata 13-16 weight portion, Auricularia 15-20 weight portion and Fructus Crataegi 12-17 weight portion.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 20 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 25 weight portion, Herba Mimosae Pudicae 25 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 16 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 weight portion, Herba Thermopsis Lanceolatae 6 weight portion, Rhizoma Dioscoreae 17 weight portion, Fructus Chaenomelis 17 weight portion, Massa Medicata Fermentata 14 weight portion, Auricularia 17 weight portion and Fructus Crataegi 15 weight portion.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the medicine of porcine contagious pleuropneumonia, described preparation method comprises the following steps:
A, to be put into by described raw medicinal material after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 30% ~ 40%, collects the raw material fine powder by 120 mesh sieves, and particulate matter remaining after sieving is for subsequent use;
B, the determining alcohol particulate matter be left after sieving being put into 5 ~ 7 times amount are the ethanol heating and refluxing extraction twice of 85%, and each 1 ~ 2 hour, merged by extracted twice liquid and leave standstill, obtain extracting solution 1, medicinal residues were for subsequent use;
C, the medicinal residues crossed by ethanol extraction in step b add 5 ~ 7 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill, obtain extracting solution 2;
D, by extracting solution 1 and extracting solution also 2-in-1, filter, when concentrating under reduced pressure relative density is 50 DEG C ~ 60 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The medicine that the raw material fine powder obtained after being sieved by step a mixes with raw material medicated powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention with clearing away heat-fire, anti-inflammation, support lung YIN nourishing, relieving cough and asthma for Therapeutic Principle, the advantage that treatment porcine contagious pleuropneumonia good effect, instant effect, toxic and side effects are little, with low cost.
Detailed description of the invention
Pig transmissible pleuritis is a kind of respiratory infectious disease of the pig caused by pleuritis Actinobacillus, with pneumonia and pleuritis for characteristic pathological changes.Present pneumonia and pleuritic characteristic symptom and pathological changes, acute person's mortality rate is high, the upper ability mistake of chronic person.The pig of various age, sex has susceptibility, and sickness rate and death have very big-difference.Pathogenic bacteria is mainly present in disease porcine respiratory, and often through air droplet transmission, the easiest contact transmission under the condition of the intensive feedstuff of jumpbogroup, boar plays an important role in propagation link.Propagation between swinery is mainly through introducing carry disease germs pig or chronic infection pig.Acute case body temperature can be increased to more than 42 DEG C, dyspnea, rapid, often stands or sits in dog and be reluctant sleeping ground, to dehisce to loll, be in anguish, as treated not in time, and often death by suffocation in 24-48 hour.Also can not see symptom before having the most acute person dead.If symptom comparatively relaxes when starting, it's more than 4 days pasts ability, and symptom progressively disappears, often can be healthy voluntarily, but the course of disease is longer.After a lot of pig infects, clinical symptom is comparatively light, in chronic process.The case of acute death, lung is aubergine, and tangent plane is like liver, and interstitial is full of color glue sample liquid body, the course of disease more than 24 hours persons, and pneumonia district often occurs that cellulosic thing invests surface, and has yellow transudate; The case that the course of disease is longer, pneumonia district strong as seen, there is the adhesive attachment of connective tissue on surface, and pneumonia focus becomes scleroma or necrotic lesion, with thoracic wall adhesion.
The present invention with clearing away heat-fire, anti-inflammation, support lung YIN nourishing, relieving cough and asthma is for Therapeutic Principle, provide a kind of medicine being used for the treatment of porcine contagious pleuropneumonia, comprise following raw medicinal material: Cortex Magnoliae Officinalis, Herba Veronicae, Oviductus Ranae, Semen Lepidii (Semen Descurainiae), Radix Scutellariae, Rhizoma Coptidis, Herba Mimosae Pudicae, Herba Swertiae davidi, Radix Rhodiolae, Caulis Bambusae In Taenia, Liquod Orzae Distillata, Rhizoma Phragmitis, Semen Raphani, Radix Rubi Parvifolii, Radix Zanthoxyli Spinifolii, Radix Aerio Fici Microcarpae, Radix Stephaniae Cepharanthae, Hui Bao, Castanea seguinii Dode (Involucrum Castaneae Seguinii) and Herba Thermopsis Lanceolatae.
Wherein, the pharmacological property of each raw medicinal material is:
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and has stomach invigorating digestion-aid effect; The checking of resisting pathogenic microbes acting body exterior-excess is bright, and Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, having obvious hypotensive effect lower than during muscle relaxant amount, this effect can not by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10 ~ 15 minutes, and the blood pressure lowering of intramuscular administration is held time, and can reach more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make increased heart rate.
Herba Veronicae: cool in nature; Acrid in the mouth.Return lung meridian.Function cures mainly: heat clearing away is fallen apart strongly fragrant.Main chronic tracheitis.
Oviductus Ranae: sweet, salty is flat.Return lung, kidney channel.Function cures mainly: the kidney invigorating and essence nourishing, nourishing YIN and moistening the lung.Weak for the deficiency of YIN, spiritlessness and weakness, palpitation and insomnia, night sweat is more than, and consumptive disease is coughed hemoptysis.
Semen Lepidii (Semen Descurainiae): pungent, bitter, Great Cold.Return lung, urinary bladder channel.Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, cure mainly damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quench one's thirst, carbuncle furuncle, eczema, eczema, auditory meatus such as to be suppurated at the card, Rhizoma Coptidis is light broad spectrum antiviral drug thing, effectively can reduce the drug resistance of Salmonella, to staphylococcus aureus, blood dissolubility streptococcus, streptococcus pneumoniae, meningococcus, dysentery bacteriums etc. have stronger bacteriostasis, amplification on Canon of Materia Medica: moderns are multiplex controls dysentery, lid is held with the dry justice of hardship.Lower valgar but see that intestinal void is oozed and let out, micro-seemingly have hemafecia, namely with it, only more do not know.Ignore again cold and heat how many, but with most agent for degree, by being cause danger to be stranded more.If QI excess is just sick, overabundant heat dysentery, just stopping of clothes, still need not use up agent also.Or empty and cold, then must not take.Remaining as " warp ".
Herba Mimosae Pudicae: sweet, puckery, cool.Slightly poisonous.Function cures mainly: clearing away heat and promoting diuresis, preventing phlegm from forming and stopping coughing, ataralgesia.For flu, infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, urinary system calculus, malaria, neurasthenia; Treating swelling and pain by traumatic injury is controlled in external, sore swollen toxin.
Herba Swertiae davidi: bitter, cool.Heat-clearing and toxic substances removing; Dampness removing.Main jaundice due to damp-heat; Cough due to lung-heat; Laryngopharynx swelling and pain; Toothache; Dysentery; Urinary tract infection; Suppurative osteomyelitis; Conjunctivitis; Adnexitis; Pelvic inflammatory disease; Herpes zoster; Scabies sore.
Radix Rhodiolae: sweet, puckery, cold.Function cures mainly: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Caulis Bambusae In Taenia: sweet, is slightly cold.Attach to the lung and stomach meridians.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Liquod Orzae Distillata: sweet; Light; Flat.Function cures mainly: strengthening the spleen and tonifying the lung; Stimulating appetite.Main insufficiency of the spleen lack of appetite; Large loose stool is thin; Chronic cough of deficiency lung
Rhizoma Phragmitis: attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.1. the Coixol contained by this product has inhibitory action to skeletal muscle, the contractile response caused by electricity irritation of frog neuromuscular specimen and the oxygen of diaphragm in rats can be suppressed to absorb and anaerobic glycolysis, and the reaction of actin-adenosine triphosphate system can be suppressed, also has more weak central inhibitory action, show as and all have sedation to rat and mice, and can with caffeine phase antagonism.On the electroencephalogram of rabbit, occur that wave amplitude increases, frequency reduces, and shows and has suppression phenomenon to the function of central nervous system.In rat tails electricity irritation test, have analgesic activity, intensity is similar to aminophenazone.Having refrigeration function, the refining complex polysaccharide class to TTG(Pseu-domonas fluorescens thalline) refrigeration function of heat pyrexia is better, and the heating caused dinitrophenol is without very acting on.Of short duration inhibitory action is had to multisynaptic reflex (cat peroneal nerve-specimen-gastrocnemius muscle).Intravenous injection can cause the of short duration decline of rabbits blood pressure, and subcutaneous injection can make blood glucose slightly decline, and to Isolated Toad Heart and isolated rabbit intestinal all in inhibitory action, has no significant effect rabbit ear blood vessel.Its toxicity is very low, Mouse oral 0.5g/(kg.d), lmo does not cause abnormal change.2. the tricin contained by this product has relexation to isolated guinea pig intestinal tube, when 2 × l0 (-5) concentration, can show suppression isolated rabbit intestinal contraction.4mg injects rabbit intestinal chamber in place, and peristaltic contraction can be made to slow down.Award Oral Administration in Rats 2mg every day, thyroxine in blood can be made to show and increase.And have slight antioxidation, adrenergic oxidation can be prevented.There is slight estrogen-like effects.Still have antitumaous effect, 6 and 12.5mg be 133 and 174% to the T/C of mice P388.
Semen Raphani: property is put down, acrid in the mouth, sweet, returns lung, spleen, stomach warp, has the de-swelling that helps digestion, effect of lowering the adverse-rising QI to resolve phlegm, cures mainly retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up cards such as breathing with cough.
Radix Rubi Parvifolii: sweet is cool.Enter lung, liver, spleen three warp.Function cures mainly: induce sweat, heat clearing away, improving eyesight, diuresis.Cure cold, cough, headache, laryngalgia, cataract, urine heat-blockage, stranguria with turbid discharge, leucorrhea, carbuncle, furuncle.
Radix Zanthoxyli Spinifolii: pungent, temperature.Return liver; Lung meridian.Function cures mainly: expelling wind and cold, relaxing muscles and tendons to promote blood circulation, analgesia.Control cough due to wind and cold, rheumatic numbness, traumatic injury, traumatic hemorrhage, constipation.
Radix Aerio Fici Microcarpae: pained is flat.Function cures mainly: expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease is suffered from abdominal pain, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury.
Radix Stephaniae Cepharanthae: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.For acute hepatitis, bacillary dysentery, acute appendicitis, stomachache, internal hemorrhage, traumatic injury, venom; Mumps is controlled in external, lymphadenitis, neurodermatitis.
Ash bag: light; Pungent; Property is put down.Return lung meridian.Function cures mainly: relieving sore-throat by clearing away heat; Removing toxic substances sore; Hemostasis.。Main acute pharyngolaryngitis; Pneumonia; Pulmonary abscess; Epistaxis; Traumatic hemorrhage.
Castanea seguinii Dode (Involucrum Castaneae Seguinii): control pneumonia, pulmonary tuberculosis, erysipelas, sore.
Herba Thermopsis Lanceolatae: sweet; Tepor.Return lung meridian.Function cures mainly: expelling phlegm for arresting cough; Loosening bowel to relieve constipation.Main cough phlegm dyspnea; Constipation with dry stool.1. phlegm-dispelling functions: herb preserved material can directly excitedly be vomitted and respiratory center, and stimulates the sensory nerve ending of stomach, reflexive promotion bronchial secretion.Use same with hippo, have eliminating the phlegm and deepen accelerate breathe effect.2. pair effect of breathing: anagyrine or the similar nicotine of eulexine effect, can breathe in reflexive excitement.Femoral vein in anesthetized cat injects eulexine 0.02mg/kg or 1.5mg/ that extracts from this product, and all have strong excited Repiration, simultaneously palpitating speed, blood pressure sharply rises, and recovers thereafter normal in company with the disappearance of respiratory stimulant effect very soon.Experiment proves, from the excited Repiration of the eulexine 0.06mg/kg that this product is extracted, be not only greatly better than the antabac of same dosage, and comparatively the antabac of 5 times (0.3mg/kg) is slightly strong.Methylcytisine effect is similar to eulexine, but compared with its weak 10-12 doubly.3. other effects: thermopsine has the inhibitory action of medium degree to vegetative ganglia.Sparteine has of short duration blocking effect to vegetative ganglia, reduces adrenal cortex and sino-carotid reactivity, improves uterus muscle tension force.Anagyrine also can suppress neuroganglion conduction of impulse, but more weak, and has curariform action mask.Dried plant has the effect (contact poison) of kill insects, and herb preserved material still can anthelmintic.The fluid extract intravenous injection of leaf can make exaggerated respiration accelerate, and blood pressure raises, and heart rate accelerates.
Medicine of the present invention also comprises: Rhizoma Dioscoreae, Fructus Chaenomelis, Massa Medicata Fermentata, Auricularia and Fructus Crataegi.
Rhizoma Dioscoreae: sweet in the mouth, property are flat, and enter lung, spleen, stomach warp, have spleen reinforcing nourishing the stomach, lung benefiting reinforces the kidney, and the effect of YIN nourishing and the production of body fluid promoting, is mainly used in weakness of the spleen and stomach, the lack of appetite poor appetite of dysfunction of the spleen in transportation, the symptoms such as the vexed diarrhoea of gastral cavity.
Fructus Chaenomelis: acid, temperature.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
Massa Medicata Fermentata: be the processed goods through fermentation after whole wheat flour and other drug (Herba Artemisiae Annuae, Herba Xanthii, the buds such as Herba polygoni hydropiperis, Semen Armeniacae Amarum, Semen Phaseoli) mixing.Get Massa Medicata Fermentata to put in pot and fry to appearance be coke black, inner coke yellow, take out, sprinkling disappears water, cools, is Massa Medicata Fermentata (parched to brown).Massa Medicata Fermentata forms through fermentation, and the product of all fermentations have the digestant effect of strengthening the spleen and stomach, and therefore, bad, feeling of stuffiness in chest abdominal distention for the digestion caused by diet internal injury quite have effect.
Auricularia: sweet, flat.Function cures mainly: fill blood, lung moistening, hemostasis.For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, spitting of blood, spit blood, epistaxis, metrorrhagia, hypertension, constipation.
Fructus Crataegi: section is dried, put in pot large stir-fry of useing force and be degree to outer wrinkly face brown, inner yellowish-brown, spray clear water, taking-up is dried, and is Fructus Crataegi (parched to brown).There is appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, promoting blood circulation to remove blood stasis, circulation of qi promoting of reducing phlegm effect, meridian distribution of property and flavor, sour, sweet, slightly warm in nature.Main component is containing chlorogenic acid, caffeic acid, Crataegolic acid, neat chrysanthemum fruit acid, Quercetin, ursolic acid, oleanolic acid, hyperin, epicatechin etc.Oral Fructus Crataegi can increase digestive enzyme, promotes decomposition and the digestion of fat, to because of eat meat or greasy too much caused by distension and fullness in the abdomen, belch, anorexia, stomachache, diarrhoea person, curative effect is especially good.In addition, modern medicines test shows, Fructus Crataegi has slow and lasting effect reduced blood pressure, and also can reduce cholesterol and triglyceride, atherosclerosis, but also can diastole coronary artery, increases myocardial contraction, to arrhythmia.Therefore, be conducive to preventing and treating hypertension, hyperlipidemia, arteriosclerosis and coronary heart disease.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine being used for the treatment of porcine contagious pleuropneumonia, be made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 19 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 26 weight portion, Herba Mimosae Pudicae 26 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 15 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 26 weight portion and Herba Thermopsis Lanceolatae 6 weight portion
The preparation method of medicine comprises the following steps:
A, to be put into by described raw medicinal material after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 30%, collects the raw material fine powder by 120 mesh sieves, and particulate matter remaining after sieving is for subsequent use;
B, the determining alcohol particulate matter be left after sieving being put into 5 times amount are the ethanol heating and refluxing extraction twice of 85%, and each 1 hour, merged by extracted twice liquid and leave standstill, obtain extracting solution 1, medicinal residues were for subsequent use;
C, the medicinal residues crossed by ethanol extraction in step b add 5 times of water gaging heating and refluxing extraction 2 times, each 1 hour, are merged by 2 extracting solution and leave standstill, obtain extracting solution 2;
D, by extracting solution 1 and extracting solution also 2-in-1, filter, when concentrating under reduced pressure relative density is 50 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The medicine that the raw material fine powder obtained after being sieved by step a mixes with raw material medicated powder.
Embodiment 2 medicine 2
Embodiments provide a kind of medicine being used for the treatment of porcine contagious pleuropneumonia, be made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 20 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 25 weight portion, Herba Mimosae Pudicae 25 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 16 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 weight portion, Herba Thermopsis Lanceolatae 6 weight portion, Rhizoma Dioscoreae 17 weight portion, Fructus Chaenomelis 17 weight portion, Massa Medicata Fermentata 14 weight portion, Auricularia 17 weight portion and Fructus Crataegi 15 weight portion.
The preparation method of medicine comprises the following steps:
A, to be put into by described raw medicinal material after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 40%, collects the raw material fine powder by 120 mesh sieves, and particulate matter remaining after sieving is for subsequent use;
B, the determining alcohol particulate matter be left after sieving being put into 6 times amount are the ethanol heating and refluxing extraction twice of 85%, and each 2 hours, merged by extracted twice liquid and leave standstill, obtain extracting solution 1, medicinal residues were for subsequent use;
C, the medicinal residues crossed by ethanol extraction in step b add 6 times of water gaging heating and refluxing extraction 2 times, each 2 hours, are merged by 2 extracting solution and leave standstill, obtain extracting solution 2;
D, by extracting solution 1 and extracting solution also 2-in-1, filter, when concentrating under reduced pressure relative density is 60 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The medicine that the raw material fine powder obtained after being sieved by step a mixes with raw material medicated powder.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the medicine of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.With the medicine 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 16 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.The medicine LD50>32.9 crude drug/kg of the Mouse oral gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the embodiment of the present invention 1 medicine 1 be 3g crude drug/day/head, pig weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By weighing machine: the dosis tolerata of the medicine of mice (average weight is in 20g) the oral administration gavage embodiment of the present invention 1 is 131 times of quantity.Therefore the acute toxicity of the medicine 1 of the embodiment of the present invention 1 is low, clinical drug safety.With the medicine 2 of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
Clinical trial
(1) laboratory animal
Pig farm, Jinan City, Shandong Province finds the growing and fattening pigs of 253 about 60kg in March, 2012, occurs that body temperature is increased to more than 41 DEG C, dyspnea and rapid, normal seat in dog and not acting as a planted agent, and dehisces to loll, time and cough, loss of appetite or absolutely useless.Owing to not treating in time, there is two pig dead.After cuing open inspection, find that lung is aubergine, tangent plane is like liver, and interstitial is full of color glue sample liquid body, and pneumonia district occurs that cellulosic thing invests surface, and has yellow transudate.Be diagnosed as the infectious pleuropneumonia of pig, choose 171 ill pigs as experiment pig.
(2) test method
171 ill pigs are divided into three experimental grouies at random, and often organize 57, three experimental grouies use the medicine 1(embodiment group 1 of the embodiment of the present invention 1 respectively), the medicine 2(embodiment group 2 of embodiment 2) and conventional medicament (matched group) treat.Medicine 1 and medicine 2 are added feedstuff according to the percentage by weight of feedstuff 5-15% by embodiment group 1 and embodiment group 2 respectively, feed according to feedstuff feed mode, use 3-5 days continuously; Conventional medicament selects Florfenicol intramuscular injection, and in medicinal liquid, crude drug content is 0.5g/ml, and twice daily, each 4-7ml, uses 3-5 days continuously.
(3) criterion of therapeutical effect
Cure: body temperature, breathing and appetite all recover normal, without cough symptom;
Effective: body temperature, breathing and appetite recover normal substantially, and cough obviously alleviates;
Invalid: symptom does not disappear or sb.'s illness took a turn for the worse even death be judged to invalid.
Wherein, effective percentage is for curing and effective percentage ratio sum.
(4) therapeutic outcome
The results are shown in Table 1, from therapeutic effect, adopt medicine of the present invention to be more than 89% to the treated effect of porcine contagious pleuropneumonia, higher than matched group.
Data as can be seen from table 1: compared with matched group, use the Drug therapy porcine contagious pleuropneumonia of the embodiment of the present invention 1 and embodiment 2, have evident in efficacy, that cure rate is high advantage; Find in long-term observation subsequently, embodiment group 1 and the embodiment group 2 ill pig of curing again sickness rate is starkly lower than the pig of matched group.
Concrete case
Case 1
In August, 2012, pig Lee raiser finds that the appearance all in various degree of 13 piglets in 4 week age is had a fever to more than 41 DEG C, dyspnea and rapid, normal seat in dog and not acting as a planted agent, dehisces to loll, time and cough, loss of appetite is even absolutely useless, an existing piglet death by suffocation before treatment, find that dead piglet lung is aubergine through cuing open inspection, tangent plane is like liver, interstitial is full of color glue sample liquid body, and pneumonia district occurs that cellulosic thing invests surface.Be diagnosed as porcine contagious pleuropneumonia, add the medicine of the embodiment of the present invention 1 of feedstuff gross weight 8% in feedstuff, use 4 days continuously, 12 piglets all recover normal.
Case 2
In March, 2012, Shandong plant finds that 40 growing and fattening pigs occur dyspnea and rapid, time and cough, loss of appetite is even absolutely useless, be diagnosed as porcine contagious pleuropneumonia through blood drawing Virus monitory, in feedstuff, add the medicine of the embodiment of the present invention 2 of feedstuff gross weight 12%, use 3 days continuously, 35 growing and fattening pigs all recover normal, effectively, continue use 2 days, 5 ill pigs all recover normal in other 5 treatments.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. be used for the treatment of the medicine of porcine contagious pleuropneumonia, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 20-30 weight portion, Herba Veronicae 15-25 weight portion, Oviductus Ranae 10-20 weight portion, Semen Lepidii (Semen Descurainiae) 10-20 weight portion, Radix Scutellariae 20-30 weight portion, Rhizoma Coptidis 20-30 weight portion, Herba Mimosae Pudicae 20-30 weight portion, Herba Swertiae davidi 10-30 weight portion, Radix Rhodiolae 10-20 weight portion, Caulis Bambusae In Taenia 10-30 weight portion, Liquod Orzae Distillata 20-30 weight portion, Rhizoma Phragmitis 10-20 weight portion, Semen Raphani 10-30 weight portion, Radix Rubi Parvifolii 10-20 weight portion, Radix Zanthoxyli Spinifolii 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Radix Stephaniae Cepharanthae 10-20 weight portion, ash bag 10-20 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 20-30 weight portion and Herba Thermopsis Lanceolatae 5-10 weight portion,
The preparation method of described medicine comprises the following steps:
A, to be put into by described raw medicinal material after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 30% ~ 40%, collects the raw material fine powder by 120 mesh sieves, and particulate matter remaining after sieving is for subsequent use;
B, the determining alcohol particulate matter be left after sieving being put into 5 ~ 7 times amount are the ethanol heating and refluxing extraction twice of 85%, and each 1 ~ 2 hour, merged by extracted twice liquid and leave standstill, obtain extracting solution 1, medicinal residues were for subsequent use;
C, the medicinal residues crossed by ethanol extraction in step b add 5 ~ 7 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill, obtain extracting solution 2;
D, by extracting solution 1 and extracting solution also 2-in-1, filter, when concentrating under reduced pressure relative density is 50 DEG C ~ 60 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The medicine that the raw material fine powder obtained after being sieved by step a mixes with raw material medicated powder.
2. the medicine being used for the treatment of porcine contagious pleuropneumonia according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 23-27 weight portion, Herba Veronicae 17-23 weight portion, Oviductus Ranae 13-17 weight portion, Semen Lepidii (Semen Descurainiae) 12-18 weight portion, Radix Scutellariae 23-27 weight portion, Rhizoma Coptidis 22-28 weight portion, Herba Mimosae Pudicae 23-28 weight portion, Herba Swertiae davidi 15-20 weight portion, Radix Rhodiolae 13-18 weight portion, Caulis Bambusae In Taenia 14-23 weight portion, Liquod Orzae Distillata 23-28 weight portion, Rhizoma Phragmitis 13-17 weight portion, Semen Raphani 15-26 weight portion, Radix Rubi Parvifolii 13-17 weight portion, Radix Zanthoxyli Spinifolii 13-17 weight portion, Radix Aerio Fici Microcarpae 12-18 weight portion, Radix Stephaniae Cepharanthae 13-18 weight portion, ash bag 13-15 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 23-29 weight portion and Herba Thermopsis Lanceolatae 5-8 weight portion.
3. the medicine being used for the treatment of porcine contagious pleuropneumonia according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 19 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 26 weight portion, Herba Mimosae Pudicae 26 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 15 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 26 weight portion and Herba Thermopsis Lanceolatae 6 weight portion.
4. be used for the treatment of the medicine of porcine contagious pleuropneumonia, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 20-30 weight portion, Herba Veronicae 15-25 weight portion, Oviductus Ranae 10-20 weight portion, Semen Lepidii (Semen Descurainiae) 10-20 weight portion, Radix Scutellariae 20-30 weight portion, Rhizoma Coptidis 20-30 weight portion, Herba Mimosae Pudicae 20-30 weight portion, Herba Swertiae davidi 10-30 weight portion, Radix Rhodiolae 10-20 weight portion, Caulis Bambusae In Taenia 10-30 weight portion, Liquod Orzae Distillata 20-30 weight portion, Rhizoma Phragmitis 10-20 weight portion, Semen Raphani 10-30 weight portion, Radix Rubi Parvifolii 10-20 weight portion, Radix Zanthoxyli Spinifolii 10-20 weight portion, Radix Aerio Fici Microcarpae 10-20 weight portion, Radix Stephaniae Cepharanthae 10-20 weight portion, ash bag 10-20 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 20-30 weight portion, Herba Thermopsis Lanceolatae 5-10 weight portion, Rhizoma Dioscoreae 10-20 weight portion, Fructus Chaenomelis 10-20 weight portion, Massa Medicata Fermentata 10-20 weight portion, Auricularia 10-20 weight portion and Fructus Crataegi 10-20 weight portion,
The preparation method of described medicine comprises the following steps:
A, to be put into by described raw medicinal material after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 30% ~ 40%, collects the raw material fine powder by 120 mesh sieves, and particulate matter remaining after sieving is for subsequent use;
B, the determining alcohol particulate matter be left after sieving being put into 5 ~ 7 times amount are the ethanol heating and refluxing extraction twice of 85%, and each 1 ~ 2 hour, merged by extracted twice liquid and leave standstill, obtain extracting solution 1, medicinal residues were for subsequent use;
C, the medicinal residues crossed by ethanol extraction in step b add 5 ~ 7 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill, obtain extracting solution 2;
D, by extracting solution 1 and extracting solution also 2-in-1, filter, when concentrating under reduced pressure relative density is 50 DEG C ~ 60 DEG C 1.38 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 100 DEG C, obtains raw material medicated powder; The medicine that the raw material fine powder obtained after being sieved by step a mixes with raw material medicated powder.
5. the medicine being used for the treatment of porcine contagious pleuropneumonia according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 23-27 weight portion, Herba Veronicae 17-23 weight portion, Oviductus Ranae 13-17 weight portion, Semen Lepidii (Semen Descurainiae) 12-18 weight portion, Radix Scutellariae 23-27 weight portion, Rhizoma Coptidis 22-28 weight portion, Herba Mimosae Pudicae 23-28 weight portion, Herba Swertiae davidi 15-20 weight portion, Radix Rhodiolae 13-18 weight portion, Caulis Bambusae In Taenia 14-23 weight portion, Liquod Orzae Distillata 23-28 weight portion, Rhizoma Phragmitis 13-17 weight portion, Semen Raphani 15-26 weight portion, Radix Rubi Parvifolii 13-17 weight portion, Radix Zanthoxyli Spinifolii 13-17 weight portion, Radix Aerio Fici Microcarpae 12-18 weight portion, Radix Stephaniae Cepharanthae 13-18 weight portion, ash bag 13-15 weight portion, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 23-29 weight portion, Herba Thermopsis Lanceolatae 5-8 weight portion, Rhizoma Dioscoreae 15-20 weight portion, Fructus Chaenomelis 15-20 weight portion, Massa Medicata Fermentata 13-16 weight portion, Auricularia 15-20 weight portion and Fructus Crataegi 12-17 weight portion.
6. the medicine being used for the treatment of porcine contagious pleuropneumonia according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Cortex Magnoliae Officinalis 25 weight portion, Herba Veronicae 20 weight portion, Oviductus Ranae 15 weight portion, Semen Lepidii (Semen Descurainiae) 15 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Coptidis 25 weight portion, Herba Mimosae Pudicae 25 weight portion, Herba Swertiae davidi 17 weight portion, Radix Rhodiolae 16 weight portion, Caulis Bambusae In Taenia 18 weight portion, Liquod Orzae Distillata 25 weight portion, Rhizoma Phragmitis 15 weight portion, Semen Raphani 21 weight portion, Radix Rubi Parvifolii 15 weight portion, Radix Zanthoxyli Spinifolii 15 weight portion, Radix Aerio Fici Microcarpae 15 weight portion, Radix Stephaniae Cepharanthae 16 weight portion, ash bag 14 weight portions, Castanea seguinii Dode (Involucrum Castaneae Seguinii) 25 weight portion, Herba Thermopsis Lanceolatae 6 weight portion, Rhizoma Dioscoreae 17 weight portion, Fructus Chaenomelis 17 weight portion, Massa Medicata Fermentata 14 weight portion, Auricularia 17 weight portion and Fructus Crataegi 15 weight portion.
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| CN105998282A (en) * | 2016-05-27 | 2016-10-12 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicinal composition for treating contagious bovine pleuropneumonia in cows and preparation method of traditional Chinese medicinal composition |
| CN110251653A (en) * | 2019-08-01 | 2019-09-20 | 郑州赛科药业科技有限公司 | For preventing and treating the Chinese medicine composition and preparation method of Porcine contagious pleuropneumonia |
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| CN101664485A (en) * | 2009-09-30 | 2010-03-10 | 北京大北农科技集团股份有限公司 | Traditional Chinese medicine for treating respiratory disease of livestock and preparation method thereof |
| CN101698024A (en) * | 2009-10-28 | 2010-04-28 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof |
| CN102133355A (en) * | 2011-03-25 | 2011-07-27 | 江西核工业金品生物科技有限公司 | Screened traditional Chinese medicine preparation for preventing and treating high fever syndrome of livestock and preparation method thereof |
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| CN101664485A (en) * | 2009-09-30 | 2010-03-10 | 北京大北农科技集团股份有限公司 | Traditional Chinese medicine for treating respiratory disease of livestock and preparation method thereof |
| CN101698024A (en) * | 2009-10-28 | 2010-04-28 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine for treating respiratory diseases and promoting growth for swine and preparation method thereof |
| CN102133355A (en) * | 2011-03-25 | 2011-07-27 | 江西核工业金品生物科技有限公司 | Screened traditional Chinese medicine preparation for preventing and treating high fever syndrome of livestock and preparation method thereof |
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