CN106543080A - 一种4‑氧代‑7‑甲氧基‑1,4‑二氢喹啉‑6‑甲酸甲酯的合成方法 - Google Patents
一种4‑氧代‑7‑甲氧基‑1,4‑二氢喹啉‑6‑甲酸甲酯的合成方法 Download PDFInfo
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- CN106543080A CN106543080A CN201611010792.6A CN201611010792A CN106543080A CN 106543080 A CN106543080 A CN 106543080A CN 201611010792 A CN201611010792 A CN 201611010792A CN 106543080 A CN106543080 A CN 106543080A
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- China
- Prior art keywords
- dihydroquinoline
- synthetic method
- nitrae
- methyl ester
- isosorbide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
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Claims (8)
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CN201611010792.6A CN106543080B (zh) | 2016-11-17 | 2016-11-17 | 一种4-氧代-7-甲氧基-1,4-二氢喹啉-6-甲酸甲酯的合成方法 |
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CN201611010792.6A CN106543080B (zh) | 2016-11-17 | 2016-11-17 | 一种4-氧代-7-甲氧基-1,4-二氢喹啉-6-甲酸甲酯的合成方法 |
Publications (2)
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CN106543080A true CN106543080A (zh) | 2017-03-29 |
CN106543080B CN106543080B (zh) | 2018-11-09 |
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CN201611010792.6A Active CN106543080B (zh) | 2016-11-17 | 2016-11-17 | 一种4-氧代-7-甲氧基-1,4-二氢喹啉-6-甲酸甲酯的合成方法 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104876864A (zh) * | 2015-06-05 | 2015-09-02 | 北京康立生医药技术开发有限公司 | 一种乐伐替尼的制备方法 |
US20160089365A1 (en) * | 2014-09-25 | 2016-03-31 | Eisai R&D Management Co., Ltd. | Immunostimulatory compound |
CN105801481A (zh) * | 2016-05-20 | 2016-07-27 | 湖南欧亚生物有限公司 | 一种乐伐替尼的合成方法 |
CN105985289A (zh) * | 2015-02-15 | 2016-10-05 | 正大天晴药业集团股份有限公司 | 一种乐伐替尼的制备方法 |
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2016
- 2016-11-17 CN CN201611010792.6A patent/CN106543080B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160089365A1 (en) * | 2014-09-25 | 2016-03-31 | Eisai R&D Management Co., Ltd. | Immunostimulatory compound |
CN105985289A (zh) * | 2015-02-15 | 2016-10-05 | 正大天晴药业集团股份有限公司 | 一种乐伐替尼的制备方法 |
CN104876864A (zh) * | 2015-06-05 | 2015-09-02 | 北京康立生医药技术开发有限公司 | 一种乐伐替尼的制备方法 |
CN105801481A (zh) * | 2016-05-20 | 2016-07-27 | 湖南欧亚生物有限公司 | 一种乐伐替尼的合成方法 |
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Denomination of invention: A synthetic method of methyl 4-oxo-7-methoxy-1,4-dihydroquinoline-6-formate Effective date of registration: 20211207 Granted publication date: 20181109 Pledgee: Qilu bank Limited by Share Ltd. Ji'nan science and technology innovation center sub branch Pledgor: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980014223 |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |