CN106540052A - A kind of Western medicine combination for treating flu and preparation method thereof - Google Patents

A kind of Western medicine combination for treating flu and preparation method thereof Download PDF

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Publication number
CN106540052A
CN106540052A CN201611109143.1A CN201611109143A CN106540052A CN 106540052 A CN106540052 A CN 106540052A CN 201611109143 A CN201611109143 A CN 201611109143A CN 106540052 A CN106540052 A CN 106540052A
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parts
flavonols
pseudoephedrine
western medicine
caffeine
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不公告发明人
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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Zhengzhou Zhengxian Pharmaceutical Technology Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/7036Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K35/644Beeswax; Propolis; Royal jelly; Honey

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Abstract

The invention discloses a kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:0.5 4 parts of Paracetamol, 13 parts of qinghaosu, 25 parts of flavonols, 0.5 4 parts of brufen, 36 parts of streptomysin, 5 10 parts of pseudoephedrine, 0.1 1.5 parts of oryzanol, 4 12 parts of vitamin C, 5 12 parts of honey, 5 15 parts of garlic juice, 38 parts of caffeine, 26 parts of glycerine and 15 32 parts of the ethanol solution that volume fraction is 55 70%.The present invention also disclosed the preparation method of the medicine.Raw material sources of the present invention are extensive, preparation process is simple, investment of production equipment low cost, it is adaptable to large-scale industrial production;In the present invention, the component such as brufen, flavonols, pseudoephedrine plays synergy, can fundamentally cure common cold, instant effect, therapeutic effect far superior to existing product and no toxic and side effect, wide market.

Description

A kind of Western medicine combination for treating flu and preparation method thereof
Technical field
The present invention relates to a kind of medicine, specifically a kind of Western medicine combination for treating flu.
Background technology
Flu, also known as the infection of the upper respiratory tract, is the general name for including nasal cavity, pharynx or acute throat inflammation.Sensu lato flu is not It is a medical diagnosis on disease, but one group of disease, including common cold, viral pharyngitis, laryngitis, herpangina, pharynx conjunctiva Heat and bacterial pharyngotonsillitis.The upper sense of narrow sense, also known as common cold, is modal acute infections of respiratory tract disease, It is in self limiting more, but incidence is higher.Common cold is commonly called as " cold ", also known as acute rhinitis or common cold, more by nose Virus causes, and secondly causes for coronavirus, parainfluenza virus, Respiratory Syncytial Virus(RSV), echovirus, Coxsackie virus etc., It is mainly shown as sniffle, such as sneeze, nasal obstruction and flows clear water sample nasal mucus, can also appear as cough, dry throat, pharynx and itch or scorching hot Sense, or even Postnasal drip sense.Morbidity can have sneeze, nasal obstruction simultaneously or after a few hours and flow the symptoms such as clear water sample nasal mucus.Morbidity 2-3 Nasal mucus retrogradation after it, often with pharyngalgia, shed tears, hypogeusia, unsmooth breath, trachyphonia etc..Although existing Western medicine can be treated general Logical flu, but cure the symptoms, not the disease, and also the toxic and side effect of long-term taking is big, and this just brings inconvenience for patient.
The content of the invention
It is an object of the invention to provide a kind of Western medicine combination for treating flu, to solve to carry in above-mentioned background technology The problem for going out.
For achieving the above object, the present invention provides following technical scheme:
A kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:Paracetamol 0.5-4 Part, qinghaosu 1-3 parts, flavonols 2-5 parts, brufen 0.5-4 parts, streptomysin 3-6 parts, pseudoephedrine 5-10 parts, Gu Wei Plain 0.1-1.5 parts, vitamin C 4-12 parts, honey 5-12 parts, garlic juice 5-15 parts, caffeine 3-8 parts, glycerine 2-6 parts and volume The ethanol solution 15-32 parts of fraction for 55-70%.
As further scheme of the invention:The Western medicine combination for treating flu, by following raw material according to weight Part composition:Paracetamol 2-4 parts, qinghaosu 1.5-3 parts, flavonols 3-5 parts, brufen 2-4 parts, streptomysin 4-6 parts, Pseudoephedrine 7-10 parts, oryzanol 0.4-1.5 parts, vitamin C 7-12 parts, honey 7-12 parts, garlic juice 8-15 parts, caffeine 5- The ethanol solution 21-32 parts of 8 parts, glycerine 3-6 parts and volume fraction for 55-70%.
As further scheme of the invention:The Western medicine combination for treating flu, by following raw material according to weight Part composition:3 parts of Paracetamol, 2.5 parts of qinghaosu, 4 parts of flavonols, 3 parts of brufen, 5 parts of streptomysin, pseudoephedrine 9 Part, 0.9 part of oryzanol, 10 parts of vitamin C, 11 parts of honey, 13 parts of garlic juice, 6 parts of caffeine, 5 parts of glycerine and volume fraction are 28 parts of the ethanol solution of 55-70%.
The preparation method of the Western medicine combination for treating flu, comprises the following steps that:
Step one, adds ethanol solution in garlic juice, then be added thereto to Paracetamol, qinghaosu, flavonols and Brufen, at normal temperatures with the rotating speed stirring 15-25 minutes of 60-120rpm, stirring seals 2-5 hours after terminating to mixer And filter, obtain the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add coffee while stirring Coffee is because caffeine is added after finishing, and mixer stirs 20-45 minutes with 150-240rpm under 30-45 degree Celsius, obtains second Mixed solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, in 100- Cooking disinfection is carried out under 200 degrees Celsius, you can obtain finished product.
Compared with prior art, the invention has the beneficial effects as follows:Extensively, preparation process is simple is raw for raw material sources of the present invention Produce equipment investment cost low, it is adaptable to large-scale industrial production;Brufen, flavonols, pseudoephedrine in the present invention Etc. component rise synergy, can fundamentally cure common cold, instant effect, therapeutic effect be far superior to existing product and Without toxic and side effect, wide market.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:0.5 part of Paracetamol, 1 part of qinghaosu, 2 parts of flavonols, 0.5 part of brufen, 3 parts of streptomysin, 5 parts of pseudoephedrine, 0.1 part of oryzanol, vitamin C4 parts, 5 parts of honey, 5 parts of garlic juice, 3 parts of caffeine, 2 parts of glycerine and 15 parts of the ethanol solution that volume fraction is 55%.
The preparation method of the Western medicine combination for treating flu, comprises the following steps that:
Step one, adds ethanol solution in garlic juice, then be added thereto to Paracetamol, qinghaosu, flavonols and Brufen, mixer are stirred 20 minutes with the rotating speed of 60rpm at normal temperatures, and stirring is sealed 3 hours and filtered after terminating, Obtain the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add coffee while stirring Coffee is because caffeine is added after finishing, and mixer is stirred 20 minutes with 150rpm under 30 degrees Celsius, obtains the second mixed solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, is taken the photograph 120 Cooking disinfection is carried out under family name's degree, you can obtain finished product.
Embodiment 2
A kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:2 parts of Paracetamol, green grass or young crops 1.5 parts of artemisin, 3 parts of flavonols, 2 parts of brufen, 4 parts of streptomysin, 7 parts of pseudoephedrine, 0.4 part of oryzanol, vitamin C 7 Part, 7 parts of honey, 8 parts of garlic juice, 5 parts of caffeine, 3 parts of glycerine and 21 parts of the ethanol solution that volume fraction is 60%.
The preparation method of the Western medicine combination for treating flu, comprises the following steps that:
Step one, adds ethanol solution in garlic juice, then be added thereto to Paracetamol, qinghaosu, flavonols and Brufen, mixer are stirred 15 minutes with the rotating speed of 80rpm at normal temperatures, and stirring is sealed 4 hours and filtered after terminating, Obtain the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add coffee while stirring Coffee is because caffeine is added after finishing, and mixer is stirred 30 minutes with 180rpm under 36 degrees Celsius, obtains the second mixed solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, is taken the photograph 150 Cooking disinfection is carried out under family name's degree, you can obtain finished product.
Embodiment 3
A kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:3 parts of Paracetamol, green grass or young crops 2.5 parts of artemisin, 4 parts of flavonols, 3 parts of brufen, 5 parts of streptomysin, 9 parts of pseudoephedrine, 0.9 part of oryzanol, vitamin C 10 Part, 11 parts of honey, 13 parts of garlic juice, 6 parts of caffeine, 5 parts of glycerine and 28 parts of the ethanol solution that volume fraction is 65%.
The preparation method of the Western medicine combination for treating flu, comprises the following steps that:
Step one, adds ethanol solution in garlic juice, then be added thereto to Paracetamol, qinghaosu, flavonols and Brufen, mixer are stirred 22 minutes with the rotating speed of 110rpm at normal temperatures, and stirring seals 4 hours and mistake after terminating Filter, obtains the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add coffee while stirring Coffee is because caffeine is added after finishing, and mixer is stirred 35 minutes with 210rpm under 42 degrees Celsius, obtains the second mixed solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, is taken the photograph 180 Cooking disinfection is carried out under family name's degree, you can obtain finished product.
Embodiment 4
A kind of Western medicine combination for treating flu, is made up of according to weight portion following raw material:4 parts of Paracetamol, green grass or young crops 3 parts of artemisin, 5 parts of flavonols, 4 parts of brufen, 6 parts of streptomysin, 10 parts of pseudoephedrine, 1.5 parts of oryzanol, vitamin C 12 Part, 12 parts of honey, 15 parts of garlic juice, 8 parts of caffeine, 6 parts of glycerine and 32 parts of the ethanol solution that volume fraction is 70%.
The preparation method of the Western medicine combination for treating flu, comprises the following steps that:
Step one, adds ethanol solution in garlic juice, then be added thereto to Paracetamol, qinghaosu, flavonols and Brufen, mixer are stirred 18 minutes with the rotating speed of 120rpm at normal temperatures, and stirring seals 4 hours and mistake after terminating Filter, obtains the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add coffee while stirring Coffee is because caffeine is added after finishing, and mixer is stirred 30 minutes with 240rpm under 45 degrees Celsius, obtains the second mixed solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, is taken the photograph 150 Cooking disinfection is carried out under family name's degree, you can obtain finished product.
500 patients, men and women are selected respectively to account for half.By 500 patient's stochastic averaginas be divided into 5 groups and per group in sex and It is almost identical on age.Patient of the product of embodiment 1-4 to 1-4 groups is taken, existing product is taken to 5 groups of patients, often It three times, each 200ml and warm water delivery service is adopted, continue 3 days, therapeutic effect is shown in Table 1.Treatment standard:Cure:Various senses Emit symptom to be wholly absent, drug withdrawal was no longer recurred in one week;Effectively:Various cold symptoms substantially mitigate more than half;It is invalid:It is various Cold symptoms do not mitigate substantially, or even increase.
Table 1
As it can be seen from table 1 the cure rate of the product of embodiment 1-4 is more than 68%, significantly larger than existing product 43%;Efficient more than 96%, significantly larger than the 64% of existing product of the product of embodiment 1-4, the product of embodiment 1-4 During patient's use, there is not any discomfort in patient.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art Understandable other embodiment.

Claims (4)

1. a kind of Western medicine combination for treating flu, it is characterised in that be made up of according to weight portion following raw material:Acetylamino Phenol 0.5-4 parts, qinghaosu 1-3 parts, flavonols 2-5 parts, brufen 0.5-4 parts, streptomysin 3-6 parts, pseudoephedrine 5-10 Part, oryzanol 0.1-1.5 parts, vitamin C 4-12 parts, honey 5-12 parts, garlic juice 5-15 parts, caffeine 3-8 parts, glycerine 2-6 Part and ethanol solution 15-32 parts that volume fraction is 55-70%.
2. the Western medicine combination for treating flu according to claim 1, it is characterised in that by following raw material according to weight Part composition:Paracetamol 2-4 parts, qinghaosu 1.5-3 parts, flavonols 3-5 parts, brufen 2-4 parts, streptomysin 4-6 parts, Pseudoephedrine 7-10 parts, oryzanol 0.4-1.5 parts, vitamin C 7-12 parts, honey 7-12 parts, garlic juice 8-15 parts, caffeine 5- The ethanol solution 21-32 parts of 8 parts, glycerine 3-6 parts and volume fraction for 55-70%.
3. the Western medicine combination for treating flu according to claim 1, it is characterised in that by following raw material according to weight Part composition:3 parts of Paracetamol, 2.5 parts of qinghaosu, 4 parts of flavonols, 3 parts of brufen, 5 parts of streptomysin, pseudoephedrine 9 Part, 0.9 part of oryzanol, 10 parts of vitamin C, 11 parts of honey, 13 parts of garlic juice, 6 parts of caffeine, 5 parts of glycerine and volume fraction are 28 parts of the ethanol solution of 55-70%.
4. the preparation method that a kind of Western medicine for treating flu as described in claim 1-3 is arbitrary is combined, it is characterised in that Comprise the following steps that:
Step one, adds ethanol solution in garlic juice, then is added thereto to Paracetamol, qinghaosu, flavonols and isobutyl Benzenpropanoic acid, mixer at normal temperatures with the rotating speed of 60-120rpm stirring 15-25 minutes, stirring seal after terminating 2-5 hours and Filter, obtain the first mixed solution;
Step 2, streptomysin, pseudoephedrine, oryzanol, vitamin C and glycerine are stirred, and add caffeine while stirring, Caffeine is added after finishing, and mixer stirs 20-45 minutes with 150-240rpm under 30-45 degree Celsius, obtains the second mixing Solution;
Step 3, honey, the first mixed solution and the second mixed solution is stirred and bottling is filtered, is taken the photograph in 100-200 Cooking disinfection is carried out under family name's degree, you can obtain finished product.
CN201611109143.1A 2016-12-06 2016-12-06 A kind of Western medicine combination for treating flu and preparation method thereof Withdrawn CN106540052A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098910A (en) * 1993-11-08 1995-02-22 赵承侠 Compounded anti-cold inhalation using pseudo ephedrine
CN101703673A (en) * 2009-09-22 2010-05-12 南通市灵通生物科技研究所 Oral liquid capable of clearing heat, resolving toxin, and preventing and treating cold and production method thereof
CN103202940A (en) * 2013-01-29 2013-07-17 袁清洪 Antiphlogistic drug
CN104706733A (en) * 2013-12-13 2015-06-17 淄博开发区亚大制药有限责任公司 Integrated Chinese and Western cold drug

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1098910A (en) * 1993-11-08 1995-02-22 赵承侠 Compounded anti-cold inhalation using pseudo ephedrine
CN101703673A (en) * 2009-09-22 2010-05-12 南通市灵通生物科技研究所 Oral liquid capable of clearing heat, resolving toxin, and preventing and treating cold and production method thereof
CN103202940A (en) * 2013-01-29 2013-07-17 袁清洪 Antiphlogistic drug
CN104706733A (en) * 2013-12-13 2015-06-17 淄博开发区亚大制药有限责任公司 Integrated Chinese and Western cold drug

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
徐小薇: "对乙酰氨基酚及复方制剂", 《中国药房》 *

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