CN107929573B - Traditional Chinese medicine for treating hand-foot-and-mouth disease and preparation method thereof - Google Patents
Traditional Chinese medicine for treating hand-foot-and-mouth disease and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a traditional Chinese medicine for treating hand-foot-and-mouth disease and a preparation method thereof, wherein the traditional Chinese medicine comprises the following components: flos Dolichoris, herba Taraxaci, Prunellae Spica, radix rehmanniae, radix Cyathulae, rhizoma anemarrhenae, radix Sophorae Flavescentis, Kochiae fructus, medulla Junci, folium Bambusae, and Glycyrrhrizae radix. The traditional Chinese medicine provided by the invention has the advantages of obvious effect, short fever duration, obvious acceleration of disappearance speed of oral ulcer and herpes zoster of hands and feet and low side effect when being used for treating hand-foot-and-mouth diseases, particularly children.
Description
Technical Field
The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a traditional Chinese medicine for treating hand-foot-and-mouth disease.
Background
The hand-foot-and-mouth disease is an infectious disease caused by enteroviruses, and the enteroviruses causing the hand-foot-and-mouth disease are more than 20, wherein the most common enteroviruses are coxsackievirus A16 type (Cox A16) and enterovirus 71 type (EV 71). It is usually seen in children under 5 years old, with symptoms of stomachache, anorexia, low fever, small herpes or ulcer in the mouth, most children will heal themselves for about one week, and few children will cause complications such as myocarditis, pulmonary edema, aseptic meningoencephalitis, etc.
However, the existing medicines for treating the hand-foot-and-mouth disease have the following defects:
(1) at present, no specific medicine with good curative effect is available on the market for treating the hand-foot-and-mouth disease;
(2) in the treatment process of the existing medicines, the fever time of a patient is long; side effects such as diarrhea and vomiting occur at a high rate; the time for eliminating symptoms such as oral ulcer and herpes of hands and feet is long.
Disclosure of Invention
In order to overcome the defects of the prior art, one of the purposes of the invention is to provide the traditional Chinese medicine for treating the hand-foot-and-mouth disease, and the traditional Chinese medicine has the advantages of obvious effect, short fever duration, obvious acceleration of disappearance speed of oral ulcer and herpes zoster of hands and feet and low side effect when being used for treating the hand-foot-and-mouth disease, particularly for treating the hand-foot-and-mouth disease of children.
The invention also aims to provide a preparation method of the traditional Chinese medicine for treating hand-foot-and-mouth disease.
One of the purposes of the invention is realized by adopting the following technical scheme:
a traditional Chinese medicine for treating hand-foot-and-mouth disease comprises the following components:
flos Dolichoris, herba Taraxaci, Prunellae Spica, radix rehmanniae, radix Cyathulae, rhizoma anemarrhenae, radix Sophorae Flavescentis, Kochiae fructus, medulla Junci, folium Bambusae, and Glycyrrhrizae radix.
Further, the traditional Chinese medicine comprises the following components in parts by weight: 6-15 parts of south bean flower, 6-15 parts of dandelion, 5-14 parts of selfheal, 4-14 parts of radix rehmanniae recen, 5-17 parts of medicinal cyathula root, 5-15 parts of rhizoma anemarrhenae, 6-15 parts of sophora flavescens, 4-16 parts of fructus kochiae, 3-15 parts of juncus effuses, 6-17 parts of bamboo leaves and 5-15 parts of liquorice.
Further, the traditional Chinese medicine comprises the following components in parts by weight: 8-13 parts of south beancurd flower, 8-13 parts of dandelion, 9-11 parts of selfheal, 6-13 parts of radix rehmanniae recen, 8-14 parts of medicinal cyathula root, 7-12 parts of rhizoma anemarrhenae, 7-13 parts of sophora flavescens, 8-12 parts of fructus kochiae, 5-11 parts of juncus effuses, 9-14 parts of bamboo leaves and 7-12 parts of liquorice.
Further, the traditional Chinese medicine comprises the following components in parts by weight: 8 parts of south bean flower, 8 parts of dandelion, 9 parts of selfheal, 6 parts of radix rehmanniae recen, 8 parts of medicinal cyathula root, 7 parts of rhizoma anemarrhenae, 7 parts of radix sophorae flavescentis, 8 parts of fructus kochiae, 5 parts of rush, 9 parts of bamboo leaf and 7 parts of liquorice.
Further, the traditional Chinese medicine comprises the following components in parts by weight: 13 parts of south bean flower, 13 parts of dandelion, 11 parts of selfheal, 13 parts of radix rehmanniae recen, 14 parts of medicinal cyathula root, 12 parts of rhizoma anemarrhenae, 13 parts of radix sophorae flavescentis, 12 parts of fructus kochiae, 11 parts of rush, 14 parts of bamboo leaf and 12 parts of liquorice.
Further, the traditional Chinese medicine comprises the following components in parts by weight: 10 parts of south bean flower, 10 parts of dandelion, 10 parts of selfheal, 10 parts of radix rehmanniae recen, 10 parts of medicinal cyathula root, 10 parts of rhizoma anemarrhenae, 10 parts of radix sophorae flavescentis, 10 parts of fructus kochiae, 12 parts of rush, 10 parts of bamboo leaf and 10 parts of liquorice.
A preparation method of a traditional Chinese medicine for treating hand-foot-and-mouth disease comprises decocting the traditional Chinese medicines according to formula amount in a decocting machine at 90-100 deg.C for 30-60 min.
Further, the decoction temperature is 98 ℃.
Further, the decoction time is 50 min.
Furthermore, the type of the decocting machine is JH07240/3001 type decocting machine.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine for treating the hand-foot-and-mouth disease comprises sophora flower, dandelion, selfheal, radix rehmanniae, medicinal cyathula root, rhizoma anemarrhenae, radix sophorae flavescentis, fructus kochiae, juncus effuses, bamboo leaves and liquorice; the preparation method provided by the invention is used for decocting, is used for treating the hand-foot-and-mouth disease of children, and has the advantages of obvious effect, shortened fever duration, obvious acceleration of oral ulcer and hand-foot herpes regression and low side effect.
The traditional Chinese medicine provided by the invention has the main effects of clearing away heart-fire, purging spleen, detoxifying and promoting diuresis. The formula of the traditional Chinese medicine is as follows: in the formula, the rehmannia root has the effects of clearing heat and cooling blood, and the bamboo leaf has the effects of clearing heart fire and reducing pathogenic fire to promote diuresis, can guide heat to descend and is excreted as a monarch drug from urine and urine; the akebiaquinata is removed, the rush is added to strengthen the effect of clearing away heart-fire, the south bean flower, the dandelion and the selfheal can clear away heat and toxic materials and promote diuresis, the rhizoma anemarrhenae can clear away heat and remove toxicity of spleen and stomach, the radix sophorae flavescentis and the fructus kochiae can clear away heat and toxic materials and promote diuresis, and the medicines are ministerial medicines; cyathula root, radix Cyathulae, as an adjuvant drug, acts to induce fire downward, to relieve constipation, and Licorice root, radix Glycyrrhizae, as a guiding drug, coordinates the effects of the other drugs in the recipe.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
A traditional Chinese medicine for treating hand-foot-and-mouth disease comprises the following components:
flos Dolichoris, herba Taraxaci, Prunellae Spica, radix rehmanniae, radix Cyathulae, rhizoma anemarrhenae, radix Sophorae Flavescentis, Kochiae fructus, medulla Junci, folium Bambusae, and Glycyrrhrizae radix.
As a further implementation mode, the traditional Chinese medicine comprises the following components in parts by weight: 6-15 parts of south bean flower, 6-15 parts of dandelion, 5-14 parts of selfheal, 4-14 parts of radix rehmanniae recen, 5-17 parts of medicinal cyathula root, 5-15 parts of rhizoma anemarrhenae, 6-15 parts of sophora flavescens, 4-16 parts of fructus kochiae, 3-15 parts of juncus effuses, 6-17 parts of bamboo leaves and 5-15 parts of liquorice. Under the proportion, the traditional Chinese medicine provided by the invention has more remarkable effect on treating the hand-foot-and-mouth disease.
As a further implementation mode, the traditional Chinese medicine comprises the following components in parts by weight: 8-13 parts of south beancurd flower, 8-13 parts of dandelion, 9-11 parts of selfheal, 6-13 parts of radix rehmanniae recen, 8-14 parts of medicinal cyathula root, 7-12 parts of rhizoma anemarrhenae, 7-13 parts of sophora flavescens, 8-12 parts of fructus kochiae, 5-11 parts of juncus effuses, 9-14 parts of bamboo leaves and 7-12 parts of liquorice. According to the proportion, the traditional Chinese medicine provided by the invention can effectively reduce the time length of fever when treating the hand-foot-and-mouth disease.
As a further implementation mode, the traditional Chinese medicine comprises the following components in parts by weight: 8 parts of south bean flower, 8 parts of dandelion, 9 parts of selfheal, 6 parts of radix rehmanniae recen, 8 parts of medicinal cyathula root, 7 parts of rhizoma anemarrhenae, 7 parts of radix sophorae flavescentis, 8 parts of fructus kochiae, 5 parts of rush, 9 parts of bamboo leaf and 7 parts of liquorice. With the proportion, the traditional Chinese medicine provided by the invention has better effect on controlling dental ulcer when treating hand-foot-and-mouth disease.
As a further implementation mode, the traditional Chinese medicine comprises the following components in parts by weight: 13 parts of south bean flower, 13 parts of dandelion, 11 parts of selfheal, 13 parts of radix rehmanniae recen, 14 parts of medicinal cyathula root, 12 parts of rhizoma anemarrhenae, 13 parts of radix sophorae flavescentis, 12 parts of fructus kochiae, 11 parts of rush, 14 parts of bamboo leaf and 12 parts of liquorice.
As a further implementation mode, the traditional Chinese medicine comprises the following components in parts by weight: 10 parts of south bean flower, 10 parts of dandelion, 10 parts of selfheal, 10 parts of radix rehmanniae recen, 10 parts of medicinal cyathula root, 10 parts of rhizoma anemarrhenae, 10 parts of radix sophorae flavescentis, 10 parts of fructus kochiae, 12 parts of rush, 10 parts of bamboo leaf and 10 parts of liquorice. The proportion is an optimal implementation scheme, the proportion adopting the scheme has the best curative effect, particularly the relative feverish days are the least, the oral ulcer and the hand-foot herpes disappear at the fastest speed, and meanwhile, the proportion not only can ensure the curative effect, but also has the lowest side effect incidence rate.
A preparation method of a traditional Chinese medicine for treating hand-foot-and-mouth disease comprises decocting the traditional Chinese medicines according to formula amount in a decocting machine at 90-100 deg.C for 30-60 min.
As a further embodiment, the decoction temperature is 98 ℃. The decoction time is 50 min. The type of the decocting machine is JH07240/3001 type decocting machine.
The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
Examples 1 to 5
The traditional Chinese medicine for treating the hand-foot-and-mouth disease comprises the specific components and the dosage (parts by weight), and further specifically, each part by weight is 1g in the following examples 1-5, and the following table 1 shows.
TABLE 1 example 1-5 Chinese medicinal formula table for treating hand-foot-and-mouth disease
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Dandelion | 6 | 15 | 8 | 13 | 10 |
| Selfheal | 5 | 14 | 9 | 11 | 10 |
| Dried rehmannia root | 4 | 14 | 6 | 13 | 10 |
| Radix cyathulae | 5 | 17 | 8 | 14 | 10 |
| Rhizoma anemarrhenae | 5 | 15 | 7 | 12 | 10 |
| All-grass of south Dolichos | 6 | 15 | 8 | 13 | 10 |
| Sophora flavescens ait | 6 | 15 | 7 | 13 | 10 |
| Kochia scoparia (L.) Schrad | 4 | 16 | 8 | 12 | 10 |
| Rush pith | 3 | 15 | 5 | 11 | 12 |
| Bamboo leaf | 9 | 17 | 9 | 14 | 10 |
| Licorice root, radix Glycyrrhizae | 5 | 15 | 7 | 12 | 10 |
Example 6
A preparation method of a traditional Chinese medicine for treating hand-foot-and-mouth disease comprises decocting the traditional Chinese medicines according to formula amount in a decocting machine at 90-100 deg.C for 30-60 min.
As a further embodiment, the decoction temperature is 98 ℃. The decoction time is 50 min. The type of the decocting machine is JH07240/3001 type decocting machine.
The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
Verification examples
The inventor systematically observes 34 cases of internal and external combined treatment of the pediatric hand-foot-and-mouth disease of the traditional Chinese medicine (the formula described in example 5) and compares the internal and external combined treatment with 30 cases of oral ribavirin granule control groups. The treatment group was administered orally after decocting the drugs using the method described in example 6. After the decoction is taken, the dregs are recovered and the hand-foot rash is washed outside. The results show that the effective rate, the antipyretic time and the rash regression time of the treatment group are obviously better than those of the control group (P <0.05 or 0.01). And (4) conclusion: the traditional Chinese medicine for internally and externally treating the hand-foot-and-mouth disease has the effects of high efficiency, and defervescence and skin rash regression in a short period. The specific result data are as follows:
two groups of curative effects: 34 cases in a treatment group, 17 cases with obvious effect (50%), 15 cases with effect (44.1%), 2 cases with no effect (5.9%), and 94.1% of total effective rate; the control group comprises 30 cases, 11 cases (36.7%) with obvious effect, 10 cases (33.3%) with effect, 9 cases (30%) with no effect, the total effective rate is 70%, the comparison difference of the two groups of total effective rates has significance (X2 is 6.533, P is less than 0.05), and the total effective rate of the treatment group is obviously superior to that of the control group.
② two groups of clinical symptom resolution time comparison: see table 2. The regression time of symptoms such as fever, oral mucosa ulcer, herpes zoster is obviously faster than that of the control group (P is less than 0.01 or 0.05).
TABLE 2 comparison of the time to regression of symptoms (days, x. + -. s)
Note that, compared with the control group,*P<0.05，**P<0.01
③ adverse reaction of the medicine: 4 cases of diarrhea in a treatment group, 2 cases of vomiting and 20 percent of the total incidence rate of adverse reactions, 3 cases of diarrhea in a control group, 6 cases of vomiting and 2 cases of rash, and the incidence rate of the adverse reactions is 36.7 percent, and the total incidence rate of the adverse reactions of the medicaments in the treatment group is obviously lower than that in the control group (P is less than 0.05) through statistical treatment.
Claims (5)
1. The traditional Chinese medicine for treating hand-foot-and-mouth disease is characterized by comprising the following raw materials in parts by weight: 10 parts of south bean flower, 10 parts of dandelion, 10 parts of selfheal, 10 parts of radix rehmanniae recen, 10 parts of medicinal cyathula root, 10 parts of rhizoma anemarrhenae, 10 parts of radix sophorae flavescentis, 10 parts of fructus kochiae, 12 parts of rush, 10 parts of bamboo leaf and 10 parts of liquorice; the treatment method by utilizing the traditional Chinese medicine for treating the hand-foot-and-mouth disease comprises the following steps: decocting the above materials in water, and washing hands and feet with the residue after oral administration.
2. A method for preparing the traditional Chinese medicine for treating hand-foot-and-mouth disease as claimed in claim 1, wherein the formula amount of the traditional Chinese medicine is put into a decocting machine for decocting at 90-100 ℃ for 30-60 min.
3. The method for preparing a traditional Chinese medicine for treating hand-foot-and-mouth disease as claimed in claim 2, wherein the decoction temperature is 98 ℃.
4. The preparation method of the traditional Chinese medicine for treating hand-foot-and-mouth disease as claimed in claim 2, wherein the decoction time is 50 min.
5. The preparation method of the traditional Chinese medicine for treating hand-foot-and-mouth disease according to claim 2, characterized in that the type of the decocting machine is JH07240/3001 decocting machine.
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Citations (2)
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| CN102784204A (en) * | 2012-08-23 | 2012-11-21 | 西安市北方医院 | Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method thereof |
| CN103341066A (en) * | 2013-07-02 | 2013-10-09 | 石家庄市第五医院 | Chinese medicine oral liquid for treating hand-foot-mouth diseases of children and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784204A (en) * | 2012-08-23 | 2012-11-21 | 西安市北方医院 | Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease and preparation method thereof |
| CN103341066A (en) * | 2013-07-02 | 2013-10-09 | 石家庄市第五医院 | Chinese medicine oral liquid for treating hand-foot-mouth diseases of children and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 迟炘.导赤散加味治疗小儿手足口病.《中国民间疗法》.2011,(第05期),46. * |
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