CN103211997B - Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof - Google Patents
Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to an antibacterial and antiviral traditional Chinese medicine composition and a preparation method thereof. The antibacterial and antiviral traditional Chinese medicine composition comprises perilla leaf, angelica dahurica, chastetree fruit, kudzu root, fructus forsythiae, south isatis root, dandelion, houttuynia cordata, verbena, blackberry lily, reed rhizome, rhizoma anemarrhenae, evodia lepta, gypsum, rehmanniae root, sweet wormwood, coix seeds, wax gourd seeds, dark plum, liquorice and platycodon grandiflorum. The preparation method of the antibacterial and antiviral traditional Chinese medicine composition comprises the following steps of: mixing medicinal materials perilla leaf, angelica dahurica and chastetree fruit to obtain a medicinal material mixture; grinding the medicinal material mixture into powder; and preparing the medicinal material mixture into a Chinese materia medica preparation. The antibacterial and antiviral traditional Chinese composition is formed by combining Chinese herbal medicinal ingredients, avoids a side effect produced by taking western medicine, also can realize the aim that multiple diseases are treated by one formula and is applicable to various diseases.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition method and preparation method thereof of anti-bacteria and anti-virus.
Background technology
People's bacterial infection or virus can cause various disease, comprise all kinds of flu, and the syndrome of WEI system in calentura, syndrome in QI system, syndrome of disease involving weifen and qifen, get angry etc., or the complication of above disease.
But in correlation technique, if the drug main Western medicine for the treatment of antibacterial or disease of viral infection, comprise the Western medicine such as antihistaminic class medicine, antibiotic or antibiotics, but these medicines of long-term taking can produce toxic and side effects to human body, such as antihistaminic class medicine has system to have inhibitory action to nervus centralis, and period in a medicine affects work; Antibiotic or antibiotic medicine can cause hemopoietic system hepatorenal damage etc.
Summary of the invention
Chinese medicine composition method that the object of the present invention is to provide a kind of anti-bacteria and anti-virus and preparation method thereof, to solve the above problems.
Provide a kind of Chinese medicine composition of anti-bacteria and anti-virus in an embodiment of the present invention, comprising:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
Additionally provide a kind of preparation method of Chinese medicine composition of anti-bacteria and anti-virus in an embodiment of the present invention, comprise the following steps:
Steps A: by Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks are bitter, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, and Radix Platycodonis mixes, and obtains medicinal material mixture;
Step B: by described medicinal material mixture grind into powder;
Step C: the powder of described medicinal material mixture is made Chinese medicine preparation.
The Chinese medicine composition of the anti-bacteria and anti-virus of the above embodiment of the present invention contains 21 kinds of Chinese crude drugs, can be used for treating the disease that antibacterial and viral infection cause, and the complication of these diseases, be mainly used in treating wind and cold, anemopyretic cold, syndrome of WEI system in heat syndrome, syndrome in QI system, syndrome of disease involving weifen and qifen and three class diseases of getting angry, and all can find in Chinese medicine books and periodicals in this Chinese medicine composition not containing toxic and side effects composition, avoid the toxic and side effects taken Western medicine and produce, the composition principle of this Chinese medicine composition monarch is:
Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae can induce sweat heat-clearing and toxic substances removing, and ten is monarch drug altogether; Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks hardships, Gypsum Fibrosum clearing away heat-fire, the Radix Rehmanniae, Herba Artemisiae Annuae clearing away heat and cooling blood, Semen Coicis, Semen Benincasae clearing away heat and discharging pus, eight is ministerial drug altogether; Fructus Mume and Radix Glycyrrhizae treatment are held concurrently and are pressed from both sides disease, and coordinating the actions of various ingredients in a prescription, is combined into adjuvant drug, and Radix Platycodonis is priming, as making medicine;
In the preparation method of above-mentioned Chinese medicine composition provided by the invention, by described steps A to C totally three steps obtain Chinese medicine composition, can be used for treating the disease that antibacterial and viral infection cause, its method in clinical application is:
Be used for the treatment of and have some inkling of a cold and mild, each 2g, one day three times; Be used for the treatment of flu mid-term and serious symptom, each 3-4g, one day three times; Be used for the treatment of syndrome of WEI system, syndrome in QI system, syndrome of disease involving weifen and qifen or high heat, each 4g, one day three times; Be used for the treatment of and get angry, each 2g, one day three times; Be used for the treatment of other infectious disease, depending on each 2-4g of state of an illness weight, one day three times; And the mode of taking of this Chinese medicine composition is based on oral.
In addition, prove through test, medicine of the present invention is 93.8% to the effective percentage of fever patient, is 95.6% to the effective percentage of acute tonsillitis patient, is 100% to the effective percentage of cold patients.In a word, medicine of the present invention is combined by Chinese medicine ingredients, avoids the side effect of taking Western medicine and producing, and can realize the object of a kind of formula treatment various disease conditions, indication is wide simultaneously.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment one
Embodiments of the invention one provide a kind of Chinese medicine composition of anti-bacteria and anti-virus, comprising:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
21 kinds of Chinese medicinal components in above-mentioned Chinese medicine composition can select any number within the scope of its parts by weight.
Embodiment two
Embodiments of the invention two provide the Chinese medicine composition of another kind of preferred anti-bacteria and anti-virus, comprising:
By weight, Folium Perillae 3-4 part, Radix Angelicae Dahuricae 3-4 part, Fructus Viticis 3-4 part, Radix Puerariae 3-4 part, Fructus Forsythiae 5-7 part, Rhizoma Et Radix Baphicacanthis Cusiae 5-7 part, Herba Taraxaci 6-10 part, Herba Houttuyniae 6-10 part, Herba Verbenae 5-7 part, Rhizoma Belamcandae 6-10 part, Rhizoma Phragmitis 2-6 part, Rhizoma Anemarrhenae 2-6 part, the bitter 4-9 part of three forks, Gypsum Fibrosum 6-10 part, Radix Rehmanniae 3-5 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 3-5 part, Semen Benincasae 3-4 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 3-4 part, Radix Platycodonis 1-4 part.
Equally, 21 kinds of Chinese medicinal components in the Chinese medicine composition of embodiment two can select any number within the scope of its parts by weight.
Embodiment three
Embodiments of the invention three provide the Chinese medicine composition of another kind of preferred anti-bacteria and anti-virus, comprising:
By weight, Folium Perillae 3 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Viticis 3 parts, Radix Puerariae 3 parts, Fructus Forsythiae 6 parts, Rhizoma Et Radix Baphicacanthis Cusiae 5.8 parts, Herba Taraxaci 8 parts, Herba Houttuyniae 8 parts, Herba Verbenae 6 parts, Rhizoma Belamcandae 8 parts, Rhizoma Phragmitis 4 parts, the Rhizoma Anemarrhenae 4 parts, bitter 7 parts of three forks, 8 parts, Gypsum Fibrosum, 4 parts, the Radix Rehmanniae, Herba Artemisiae Annuae 2.2 parts, Semen Coicis 4 parts, Semen Benincasae 3 parts, Fructus Mume 5 parts, 3 parts, Radix Glycyrrhizae, Radix Platycodonis 2 parts.
The Chinese medicine composition of above-mentioned three embodiments all contains 21 kinds of Chinese crude drugs, can reach following effect:
Can be used for treatment antibacterial and viral infection cause disease, and the complication of these diseases, be mainly used in treating wind and cold, anemopyretic cold, syndrome of WEI system in heat syndrome, syndrome in QI system, syndrome of disease involving weifen and qifen and three class diseases of getting angry, and all can find in Chinese medicine books and periodicals in this Chinese medicine composition not containing toxic and side effects composition, avoid the toxic and side effects taken Western medicine and produce, the composition principle of this Chinese medicine composition monarch is:
Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae can induce sweat heat-clearing and toxic substances removing, and ten is monarch drug altogether; Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks hardships, Gypsum Fibrosum clearing away heat-fire, the Radix Rehmanniae, Herba Artemisiae Annuae clearing away heat and cooling blood, Semen Coicis, Semen Benincasae clearing away heat and discharging pus, eight is ministerial drug altogether; Fructus Mume and Radix Glycyrrhizae treatment are held concurrently and are pressed from both sides disease, and coordinating the actions of various ingredients in a prescription, is combined into adjuvant drug, and Radix Platycodonis is priming, as making medicine.
The method in clinical application of above-mentioned Chinese medicine composition is:
Be used for the treatment of and have some inkling of a cold and mild case, each 2g, one day three times; Be used for the treatment of flu mid-term and serious symptom, each 3-4g, one day three times; Be used for the treatment of syndrome of WEI system, syndrome in QI system, syndrome of disease involving weifen and qifen or high heat, each 4g, one day three times; Be used for the treatment of and get angry, each 2g, one day three times; Be used for the treatment of other infectious disease, depending on each 2-4g of state of an illness weight, one day three times.
In addition, prove through test, Chinese medicine composition of the present invention is 93.8% to the effective percentage of fever patient, be 95.6% to the effective percentage of acute tonsillitis patient, be 100% to the effective percentage of cold patients, have therapeutic effect to acute pharyngitis, bronchitis, aphtha, eye hordeolum, herpes simplex, urinary system infection, otitis media, gingivitis, furuncle enteritis, sinusitis, acute conjunctivitis etc.
In a word, Chinese medicine composition of the present invention is combined by Chinese medicine ingredients, not only avoid the side effect of taking Western medicine and producing, and can realize the object of a kind of formula treatment various disease conditions, indication is wide simultaneously.The drug component that above-mentioned three embodiments are mentioned simultaneously can adopt any number within the scope of the number of its correspondence, all can reach above-mentioned effect.
In addition, relative to existing antibiotics and the antibiotic that can reach identical treatment effect, because compositions of the present invention contains multi-medicament composition, composition variation, thus antibacterial and virus not easily produce drug resistance to it, thus relative to existing antibiotics and antibiotic, this compositions range of application is wider.The feature of the medicine of existing treatment antibacterial or disease of viral infection is simultaneously: a kind of medicine can only be treated a kind of sick, when patient suffers from multiple disease simultaneously (such as complication), usually needs to take multi-medicament, adds the burden of patient; Pharmaceutical composition of the present invention then avoids this puzzlement, it comprises plurality of Chinese component, can treat the various diseases that antibacterial or viral infection cause, the pharmacology of said composition and the provable this point of clinical practice situation.
The pharmacology of Chinese medicine composition of the present invention is as follows in detail:
Folium Perillae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, the Rhizoma Anemarrhenae, three fork hardships have broad-spectrum antibacterial action, kill or inhibitory action staphylococcus, escherichia coli, dysentery bacterium, Hemolytic streptococcus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, bordetella pertussis, tubercule bacillus, Diplococcus pneumoniae, bacillus subtilis, bacillus enteritidis, micrococcus catarrhalis, diphtheria corynebacterium.
Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Houttuyniae, Rhizoma Belamcandae, three fork hardships have broad-spectrum disease resistance toxic action, have inhibitory action to common cold virus, influenza virus.
Herba Houttuyniae clearing the nasal passage, controls polytype rhinitis, sinusitis, eliminates nasal obstruction.
Herba Verbenae, Rhizoma Belamcandae, Gypsum Fibrosum reduce Vascular Permeability, reduce inflammatory exudation, eliminate rhinorrhea.
The Radix Rehmanniae, Radix Glycyrrhizae, Semen Benincasae have antiinflammatory, antiallergic, the effect of glucocorticoid sample.
Herba Houttuyniae, Rhizoma Belamcandae, the Rhizoma Anemarrhenae, Radix Puerariae can expand cerebral arteries and coronary artery, improve myocardial ischemia and cerebral blood circulation.
The Radix Rehmanniae has cardiotonic
Fructus Viticis, the Radix Angelicae Dahuricae, Herba Houttuyniae, Herba Verbenae, Gypsum Fibrosum have analgesic activity.
Folium Perillae, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Verbenae, the Rhizoma Anemarrhenae, three forks hardships, Gypsum Fibrosum have refrigeration function.
The effect of reducing blood pressure of Radix Puerariae, Rhizoma Belamcandae.
Fructus Forsythiae, Herba Houttuyniae, the Rhizoma Anemarrhenae have diuresis.
Rhizoma Et Radix Baphicacanthis Cusiae, Herba Houttuyniae, gypsum increasing phagocytic activity of leukocytes, enhancing body resistance.
Baphicanthus cusia radical cure aphtha.
Herba Taraxaci, Herba Houttuyniae, three fork hardships can treat that furuncle swells and ache, furunculosis breast ulcer.
Herba Taraxaci controls conjunctivitis, blepharitis, hordeolum.
Folium Perillae, Herba Taraxaci control upper respiratory tract infection, reduce bronchial secretion, alleviate bronchospasm, relieving cough and asthma.
Rhizoma Belamcandae, three forks are bitter, Gypsum Fibrosum treatment tonsillitis, pharyngolaryngitis.
The antibacterial of Herba Houttuyniae to antibiotics drug resistance has antibacterial action, can treat enteritis, dysentery.
Herba Taraxaci can treat pelvic inflammatory disease, acute appendicitis, cholecystitis, urinary system infection.
Present invention also offers the preparation method of the Chinese medicine composition of above-mentioned anti-bacteria and anti-virus.
Embodiment four:
The preparation method of the Chinese medicine composition of the anti-bacteria and anti-virus above mentioned, comprises the following steps:
Step 101: by Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks are bitter, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, and Radix Platycodonis mixes, and obtains medicinal material mixture;
Step 102: by described medicinal material mixture grind into powder;
Step 103: the powder of described medicinal material mixture is made Chinese medicine preparation.
In above-mentioned preparation method, by described step 101 to 103 totally three steps obtain Chinese medicine composition, can be used for treating the disease that antibacterial and viral infection cause.
Wherein, described Chinese medicine preparation can be following in one: capsule, pill, tablet, powder.These preparations are all suitable for directly oral, and more convenient patient takes.
Preferably, when being prepared as capsule preparations, described in make Chinese medicine preparation and comprise: the powder of described medicinal material mixture is incapsulated.Wherein preferably, described capsule is No. 0 gastric-dissolved capsule.
In addition, the granularity of powder described in described step 102 is 100-300 order, and more preferably, the granularity of described powder is 150-300 order.
Embodiment five
Present embodiments provide Chinese medicine composition of a kind of preferred anti-bacteria and anti-virus and preparation method thereof, wherein Chinese medicine composition adopts the proportioning of above-described embodiment three, and preparation method is:
Step 201: by Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks are bitter, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, and Radix Platycodonis mixes, and obtains medicinal material mixture;
Step 202: by described medicinal material mixture grind into powder;
Step 203: the powder of described medicinal material mixture is loaded No. 0 gastric solubility capsule, make capsule preparations.
Capsule every the content of dispersion that above-described embodiment five finally obtains is 0.5 ± 0.02g.
Clinical practice situation
Chinese medicine composition of the present invention used in following all clinical practices is all product that embodiment five provides.
In order to further describe performance of the present invention in detail, the following provide three routine patient's Cures for three kinds of various disease.
Cold clinical application examples
Zhang, female, 48 years old, symptom was: nasal obstruction rhinorrhea one day, because of onset of suffering from cold, from the beginning of aversion to wind, itching of the throat, sneeze, was then with more clear rare nasal mucus, with nasal obstruction, took WEI C YINQIAO PIAN and do not take a turn for the better for 1 day, tongue fur whiting floating pulse; Be diagnosed as anemofrigid cold.Take medicine of the present invention, each 5, one day three times, after taking medicine one day, above-mentioned symptom alleviates, and continue to take medicine two days, symptom disappears completely, cures.
Heating clinical practice example
Go into business certain, man, and 30 years old, symptom was: mouth and nose are warmed, fear of cold, headache, systemic pain half a day, flushing, yellow fur, rapid pulse, body temperature 39.2 DEG C, is diagnosed as calentura from the beginning of syndrome of WEI system.Take medicine of the present invention, each 8, one day three times, after taking medicine one day, above-mentioned symptom disappears, body temperature 37 DEG C, cures.
Acute tonsillitis clinical practice example
Zhang, man, 27 years old, symptom was: have sore throat one day, and from the beginning of conscious fear of cold, heating, headache, systemic pain, thirsty, irritated, pharyngalgia obvious, and red tongue with yellow fur is thick, full and large pulse, and there is several yellow-white pus point on antiadoncus, hyperemia, surface, body temperature 39.8 DEG C.Be diagnosed as acute tonsillitis.Take medicine of the present invention, one time 8, one day three times, take medicine one day, above-mentioned symptom alleviates, and body temperature is down to 37.8 DEG C, then take this medicine two days later symptom eliminate completely, the congested enlargement of tonsil is disappeared, and body temperature 37 DEG C is cured.
Except above-mentioned three routine clinical practices, also has the clinical example for Other diseases, but do not enumerate at this, simultaneously in order to more absolutely prove the performance of this compositions, the present invention has also made statistics to Chinese medicine composition applicable cases clinically: clinical total treatment example is 1739 examples, total effective rate is up to 91.3%, and the treatment situation of each disease is as shown in table 1, table 2, table 3.
Table 1 the present invention is to the treatment situation of various disease
Table 2 the present invention is to the treatment situation of various disease
Table 3 the present invention is to the treatment situation of various disease
From data in above-mentioned three tables, medicine of the present invention may be used for treatment heating, acute pharyngitis, acute tonsillitis, flu, bronchitis, aphtha, eye hordeolum, herpes simplex, urinary system infection, gets angry, the various diseases such as otitis media, gingivitis, furuncle, enteritis, sinusitis, acute conjunctivitis, and there is higher effective percentage (effectively refer to and take in medicine of the present invention seven days, the symptom of each disease is all eliminated).Wherein, treatment flu is totally 696 examples, and effective percentage is 100%.Treatment acute tonsillitis (and gas is with sick) totally 110 examples, effective percentage is 96.4%.
In addition, the curative effect of Chinese medicine composition of the present invention and compound recipe cold drug, amoxicillin has also been made contrast test by the present invention respectively.
The present invention and compound recipe cold drug treat the comparitive study of catching a cold
The diagnostic criteria of flu: sneeze, rhinorrhea, nasal obstruction.
Curative effect is divided into healing, effective, effective three ranks, and " effective percentage " refers to the ratio that three ranks are total, the evaluation criterion of three ranks is:
Cure: take medicine three to four days, all transference cures, drug withdrawal is without recurrence.
Effective: to take medicine three to four days, all transference cures, end-of-dose failure, need maintain medication to the 7th day.
Effective: take medicine three to four days, symptom alleviates, and does not disappear completely, medication need be maintained to the 7th day.
Case selection:
52 example flu patients are divided into test group and matched group at random, and test group takes medicine of the present invention, and matched group takes compound recipe cold drug.Test group and each 26 examples of matched group, be of the similar age, be 18 to 58 years old for two groups, the mean age is respectively 36.5 years old and 36.6 years old, each 18 examples of male, each 8 examples of women, clinical manifestation is similar, through t inspection, two groups without significant difference p>0.05, thus two groups have comparability.
Therapeutic Method:
Each four of administration during test group first visit, three times on the one, oral medication three days.
Each 4 of administration during matched group first visit, three times on the one, oral medication three days.
Result:
Disappearance person in sneeze, rhinorrhea 2 hours: test group is 25 examples, accounts for 96%, average regression time 1.5 hours; And matched group accounts for 77%, average regression time 2.1 hours.
Have a stuffy nose disappearance person in 4 hours: test group is 21 examples, and account for 80.7%, average regression time is 3.3 hours; Matched group accounts for 61%, and average regression time is 4 hours.
Through t inspection, in elimination sneeze, rhinorrhea, nasal obstruction, test group is all better than matched group, and two groups of Different therapeutical effects are remarkable.
In addition, also compares two groups take medicine after suppression situation to nervus centralis, evaluate symptom and comprise: be lassitude, tired, drowsiness, dizzy.
Table 4 the present invention and compound recipe cold drug are to the suppression situation of nervus centralis
| Symptom | Lassitude | Tired | Drowsiness | Dizzy |
| Test group percentage ratio | 0 | 0 | 0 | 0 |
| Matched group percentage ratio | 34.6% | 26.9% | 23.1% | 15.4% |
[0108]can be found out by the comparative result of above-mentioned effects and side effects, relative to compound recipe cold drug, the present invention is not only more effective to flu, and has no side effect to human body, and period in a medicine does not affect the normal work of patient.
The comparitive study of acute tonsillitis is treated in the present invention and amoxicillin
The diagnostic criteria of acute tonsillitis:
Tcm diagnosis: simultaneous occurrence of syndromes of both QI and WEI systems, aversion to cold, high heat, headache, systemic pain, thirsty, red tongue with yellow fur, floating and rapid pulse or loud sliding number.
Western medicine diagnose: onset is anxious, have the high heat headache of fear of cold, systemic pain, pharyngalgia is obvious, and check and see pharyngeal recess acute congestion, antiadoncus, there is yellow-white pustule on surface, and crypts has yellow-white point-like exudate, and hemogram leukocyte is more, body temperature 38.3-39.5 DEG C.
Curative effect is divided into healing, effective, effective, invalid four ranks, and " effective percentage " refers to the ratio that first three rank is total, the evaluation criterion of four ranks is:
Recovery from illness: take medicine four days, symptom disappears completely, high heat is moved back to the greatest extent, and the congested swelling of tonsil is disappeared, and crypts is without purulent secretion, and hemogram recovers normal, and light red tongue tongue Be is white, arteries and veins one expiration and inspiration five to.
Effective: take medicine 4 days, the state of an illness is clearly better, but above-mentioned symptom has one to two not recover normal.
Effective: body temperature disappears, symptom partial disappearance, the congested swelling of tonsil.
Invalid: symptom and sign is without improvement.
Case selection:
Patient 205 example being diagnosed as acute tonsillitis in outpatient service, be divided into test group and matched group at random, test group takes Chinese medicine composition of the present invention, and matched group takes amoxicillin.
Test group 110 example, male 64 example, women 46 example.
Matched group 95 example, male 51 example, women 44 example.
Be of the similar age, be 20 to 58 years old for two groups.Mean age is respectively 38.5 years old and 38.7 years old, and clinical manifestation is similar, and through t inspection, two groups, without significant difference p>0.05, have comparability.
Therapeutic Method:
Test group takes Chinese medicine composition of the present invention, each 8, one day three times, orally serve on 4 days.
Matched group takes amoxicillin, each 0.5g, one day four times, serve on four days.
Curative effect:
It is as shown in the table, and the effective percentage of test group is 96.4%, and the effective percentage of matched group is 97.9%.
The comparitive study result of acute tonsillitis is treated in table 5 the present invention and amoxicillin
| Medicine | Cure | Significantly | Effectively | Invalid |
| Test group | 77.3% | 11.8% | 7.3% | 3.6% |
| Matched group | 75.8% | 13.6% | 5.3% | 5.3% |
Conclusion:
Through t inspection, P>0.05, compares without significant difference for two groups, and visible Chinese medicine composition of the present invention acts on similar to amoxicillin, treatment acute tonsillitis therapeutic equivalence.But compare amoxicillin, Chinese medicine composition of the present invention can not cause allergic reaction, and range of application is wider.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition for anti-bacteria and anti-virus, is characterized in that, its Chinese medicine ingredients is made up of following ingredients:
By weight, Folium Perillae 1-5 part, Radix Angelicae Dahuricae 1-5 part, Fructus Viticis 1-5 part, Radix Puerariae 1-5 part, Fructus Forsythiae 2-10 part, Rhizoma Et Radix Baphicacanthis Cusiae 2-10 part, Herba Taraxaci 2-14 part, Herba Houttuyniae 2-14 part, Herba Verbenae 2-10 part, Rhizoma Belamcandae 2-14 part, Rhizoma Phragmitis 1-7 part, Rhizoma Anemarrhenae 1-7 part, the bitter 1-13 part of three forks, Gypsum Fibrosum 2-14 part, Radix Rehmanniae 1-7 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 1-7 part, Semen Benincasae 1-5 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 1-5 part, Radix Platycodonis 1-4 part.
2. the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 1, is characterized in that, its Chinese medicine ingredients is made up of following ingredients:
By weight, Folium Perillae 3-4 part, Radix Angelicae Dahuricae 3-4 part, Fructus Viticis 3-4 part, Radix Puerariae 3-4 part, Fructus Forsythiae 5-7 part, Rhizoma Et Radix Baphicacanthis Cusiae 5-7 part, Herba Taraxaci 6-10 part, Herba Houttuyniae 6-10 part, Herba Verbenae 5-7 part, Rhizoma Belamcandae 6-10 part, Rhizoma Phragmitis 2-6 part, Rhizoma Anemarrhenae 2-6 part, the bitter 4-9 part of three forks, Gypsum Fibrosum 6-10 part, Radix Rehmanniae 3-5 part, Herba Artemisiae Annuae 1-4 part, Semen Coicis 3-5 part, Semen Benincasae 3-4 part, Fructus Mume 1-9 part, Radix Glycyrrhizae 3-4 part, Radix Platycodonis 1-4 part.
3. the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 2, is characterized in that, its Chinese medicine ingredients is made up of following ingredients:
By weight, Folium Perillae 3 parts, the Radix Angelicae Dahuricae 3 parts, Fructus Viticis 3 parts, Radix Puerariae 3 parts, Fructus Forsythiae 6 parts, Rhizoma Et Radix Baphicacanthis Cusiae 5.8 parts, Herba Taraxaci 8 parts, Herba Houttuyniae 8 parts, Herba Verbenae 6 parts, Rhizoma Belamcandae 8 parts, Rhizoma Phragmitis 4 parts, the Rhizoma Anemarrhenae 4 parts, bitter 7 parts of three forks, 8 parts, Gypsum Fibrosum, 4 parts, the Radix Rehmanniae, Herba Artemisiae Annuae 2.2 parts, Semen Coicis 4 parts, Semen Benincasae 3 parts, Fructus Mume 5 parts, 3 parts, Radix Glycyrrhizae, Radix Platycodonis 2 parts.
4. a preparation method for the Chinese medicine composition of a kind of anti-bacteria and anti-virus described in any one of claim 1-3, is characterized in that, comprise the following steps:
Steps A: by Folium Perillae, the Radix Angelicae Dahuricae, Fructus Viticis, Radix Puerariae, Fructus Forsythiae, Rhizoma Et Radix Baphicacanthis Cusiae, Herba Taraxaci, Herba Houttuyniae, Herba Verbenae, Rhizoma Belamcandae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, three forks are bitter, Gypsum Fibrosum, the Radix Rehmanniae, Herba Artemisiae Annuae, Semen Coicis, Semen Benincasae, Fructus Mume, Radix Glycyrrhizae, and Radix Platycodonis mixes, and obtains medicinal material mixture;
Step B: by described medicinal material mixture grind into powder;
Step C: the powder of described medicinal material mixture is made Chinese medicine composition.
5. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4, is characterized in that, the dosage form of described Chinese medicine composition is capsule.
6. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 5, is characterized in that, described capsule is prepared by following methods:
The powder of described medicinal material mixture is incapsulated.
7. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 6, is characterized in that, described capsule is No. 0 gastric solubility capsule.
8. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4, is characterized in that, the granularity of described powder is 100-300 order.
9. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 4, is characterized in that, the dosage form of described Chinese medicine composition be following in one: pill, tablet, powder.
10. the preparation method of the Chinese medicine composition of a kind of anti-bacteria and anti-virus according to claim 8, is characterized in that, the granularity of described powder is 150-300 order.
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| CN103961575A (en) * | 2014-05-08 | 2014-08-06 | 肖勇 | Chinese patent medicine for treating cold and preparation method thereof |
| CN104840822A (en) * | 2015-06-02 | 2015-08-19 | 岳兵兵 | Traditional Chinese medicine composition for treating otitis media |
| CN104840823A (en) * | 2015-06-02 | 2015-08-19 | 岳兵兵 | Traditional Chinese medicine preparation for treating otitis media and preparation method |
| CN104983944A (en) * | 2015-06-15 | 2015-10-21 | 山东大学 | Compound Chinese herbal medicine anti-microbial anti-viral agent and preparing method and application thereof |
| CN105125741A (en) * | 2015-07-27 | 2015-12-09 | 袁忠祥 | Traditional Chinese medicine having functions of immunity enhancement and longevity improvement and preparation method and application of traditional Chinese medicine |
| CN105748989B (en) * | 2016-03-14 | 2020-03-10 | 赵剑锋 | Antibacterial and antiviral composition and preparation method thereof |
| CN107854670A (en) * | 2017-11-01 | 2018-03-30 | 罗建平 | Prevent and treat Chinese herbal feed additive of pig anemofrigid cold and preparation method thereof |
| CN111467414A (en) * | 2020-02-18 | 2020-07-31 | 上海蓝盎医学科技发展有限公司 | A Chinese medicinal composition for treating new coronavirus, and its preparation method |
| CN113713070A (en) * | 2021-10-11 | 2021-11-30 | 徐州天意动物药业股份有限公司 | Antibacterial and antiviral traditional Chinese medicine composition and preparation method thereof |
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