CN106490285A - A kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof - Google Patents
A kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof Download PDFInfo
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- CN106490285A CN106490285A CN201610949112.0A CN201610949112A CN106490285A CN 106490285 A CN106490285 A CN 106490285A CN 201610949112 A CN201610949112 A CN 201610949112A CN 106490285 A CN106490285 A CN 106490285A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
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- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof, belong to technical field of health care food.Health-care sweets formula of the present invention is as follows：Lactoferrin, lysozyme, lactoperoxidase, FOS, Tea Polyphenols, microcrystalline cellulose, magnesium stearate, starch, fruit powder；The present invention adopts wet granule compression tablet technology, by supplementary material preparation, granulation, drying, whole grain, total mixing, compressing tablet and packaging finished product.Health-care sweets prepared by the present invention have the cariogenic growth of microorganism in suppression oral cavity, kill the effect such as lactic acid bacteria present in slot and other caries bacterias, so as to reach the purpose of preventing decayed tooth permanent tooth.The health-care sweets of the present invention also have regulation flora, antibacterial, the health-care efficacy of strengthen immunity, and the active component of supplementary material composition involved in the present invention is food additives category, and is applied to multiple infant food fields, and long use will not produce side effect.
Description
Technical field
The present invention relates to a kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof, and in particular to one kind can be prevented
With treatment deciduous dental caries, suppression oral bacteria growth, the health-care sweets of strengthen immunity and preparation method thereof, belong to health food
Technical field.
Background technology
Dental caries are things containing confectionery（Particularly sucrose）After entering oral cavity, in the bacterial plaque through cariogenic bacteria effect, fermentation produces
Acid, these acid from tooth face structure weakness where invade, the inorganic matter of dissolved destruction tooth and produce.Bacterium in bacterial plaque with
Dental caries morbidity is closely related.With the generation of dental caries, in bacterial plaque, bacterium ratio constantly can change.During dental caries are fallen ill
When streptococcus mutans, actinomyces, lactobacillus and saccharomycete quantity increase, and Streptococcus sanguis and Wei Yong bacterium numbers amount are reduced.Common
Cariogenic bacterium includes streptococcus, lactobacillus and actinomyces, and wherein streptococcus mutans and lactobacillus acidophilus is main cause
Dental caries bacterium.In China's Incidence of caries about 35%～45%, children may be up to 70% or so.The infection of dental caries is irreversible, so dental caries
Tooth should be puted prevention first with health care.
Lactoferrin (lactoferrin, LF) is a kind of safe and reliable natural materials extracted from animal milk, it
It is a kind of multifunctional protein, is not only involved in the transhipment of iron, and there is broad-spectrum antiseptic, anti-oxidant, anticancer, adjust immune system etc.
A kind of powerful biological function, it is considered to be the food and feed additive of novel antibacterial, cancer therapy drug and great exploitation potential, and
Food enrichment was identified as in 2012.Which is widely used in dispensed food for baby at present, and nutritional supplementation is made up
The aspects such as product, food preservative, ancillary drug treatment.
Lysozyme（Lysozyme, Lyz）Hydrolyze also known as muramidase, Lysozyme or N- acetyl mureins glycan
Enzyme, is a kind of alkaline enzyme that can be hydrolyzed and stick polysaccharide in pathogenic bacteria, is widely present in the tissue of higher mammal, saliva, tear, blood
Clearly, in lymph etc. and protozoan, insect, plant and microorganism.Which is mainly by destroying the N- acetyl cell walls in cell membrane
β-Isosorbide-5-Nitrae glycosidic bond between acid and NAG, makes the insoluble glutinous polysaccharide of cell membrane resolve into soluble glycopeptide, causes
Cell wall rupture content is escaped and makes bacterolysis.Lysozyme has antibacterial, anti-inflammatory, the effect such as antiviral.There is research to show,
Lysozyme in oral cavity participates in the regulation process of homeostasis, and the generation, development with carious tooth, diseases of oral mucosa and periodontosis has one
Determine relation.
Lactoperoxidase is a kind of oxidoreducing enzyme in breast, mammary gland, salivary gland, lachrymal gland in mammal and its point
Can find in secretion, its biological significance is that it constitutes a kind of natural defending system, while having antibacterial activity and protection
Zooblast is by snperoxiaized effect.
FOS is a kind of water-soluble dietary fiber, is preferable low-calorie functional sweetener, it is possible to decrease serum
Middle cholesterol and the content of triglycerides, promote the absorption of nutrition, the especially absorption of calcium, preventing and treating diarrhoea and constipation, to enteron aisle
Beneficial bacterium has proliferation function, simultaneously because FOS can not be provided mouth by streptococcus mutans using insoluble glucan is generated
Chamber microbe deposition/product acid and the place (tartar) of corrosion, therefore can prevent carious tooth.
Tea Polyphenols (Tea Polyphenols) is the general name of Polyphenols of Tea, and Tea Polyphenols has antioxidation,
Also there is bacteriostasis.Tea polyphenolic compoundses can kill lactic acid bacteria present in slot and other caries bacterias, have
Suppress the effect of glucose polymerisation enzymatic activity, such germ cannot on tooth implantation, effectively interrupted making carious tooth to be formed
Process, while Tea Polyphenols can kill the putrefactivebacteria by the protein residued in slot for food.According to another relevant information
Show, carry out " tea therapy is gargled after meal " test in pupil, caries incidence can reduce by 80%.
Content of the invention
It is an object of the invention to overcoming above-mentioned weak point, there is provided a kind of preventing decayed tooth health-care sweets containing lactoferrin and its
Preparation method.
According to the technical scheme that the present invention is provided, a kind of preventing decayed tooth health-care sweets containing lactoferrin, formula rate is by weight
Part meter is as follows：Lactoferrin 30-50 parts, lysozyme 3-10 parts, lactoperoxidase 3-10 parts, FOS 3-10 parts, tea are more
Phenol 3-10 parts, microcrystalline cellulose 3-6 parts, magnesium stearate 0.5-2 parts, amylum pregelatinisatum 2-5 parts, starch slurry 2-5 parts, dried starch 1-
5 parts, fruit powder 1-30 part.
Further, formula meter is as follows：40 parts of lactoferrin, 5 parts of lysozyme, 5 parts of lactoperoxidase are low
7 parts of Fructooligosaccharides, 8 parts of Tea Polyphenols, 4 parts of microcrystalline cellulose, 1 part of magnesium stearate, 2 parts of amylum pregelatinisatum, 5 parts of starch slurry, dried starch 3
Part, 20 parts of fruit powder.
The preparation method of the preventing decayed tooth health-care sweets containing lactoferrin, by weight step are as follows：
（1）Supplementary material prepares：By lactoferrin 30-50 parts, lysozyme 3-10 parts, lactoperoxidase 3-10 parts, FOS
3-10 parts, Tea Polyphenols 3-10 parts, microcrystalline cellulose 3-6 parts cross 80 mesh sieves after crushing, and are placed in granulator in proportion after precise
Middle mixing；
（2）Granulation：By step（1）Resulting material is placed in comminutor and continuously adds amylum pregelatinisatum 2-5 parts, starch slurry 2-5 parts
With dried starch 1-5 parts, it is well mixed, obtains wet granular；
（3）Dry：By step（2）Gained wet granular is transferred in vacuum drying chamber and dries, and it is 50-60 DEG C to arrange EAT,
Vacuum 0.075-0.09MPa, drying time 15-30min, with 16 mesh sieve whole grains after, be laid in stainless steel disc, thickness does not surpass
Cross 3cm；Continue to be placed in vacuum drying chamber, dry to pellet moisture≤3%；
（4）Whole grain：By step（3）Dried particle is placed in pelletizing machine crosses 16 mesh nylon mesh whole grains；
（5）Total mixing：By step（4）Particle after gained whole grain is moved in granulator and is mixed；Add fruit powder 1-30 part and tristearin
Sour magnesium 0.5-2 parts, machine, are well mixed, and moisture is surveyed in then sampling；
（6）Compressing tablet：According to the average piece weight of particle, from die needed, compressing tablet in rotary tablet machine is put；
（7）Packaging：Packed from appropriate packing machine, it is desirable to seal, airtight, attractive packages, complete, that is, produced
Preventing decayed tooth health-care sweets of the product containing lactoferrin.
Beneficial effects of the present invention：Candy prepared by the present invention has the cariogenic growth of microorganism in suppression oral cavity, kills in tooth
Lactic acid bacteria present in seam and other caries bacterias etc. act on, so as to reach the purpose of preventing decayed tooth permanent tooth.The candy of the present invention also has
There are regulation flora, antibacterial, the health-care efficacy of strengthen immunity, the active component of supplementary material composition involved in the present invention to be food
Product additive category, and multiple infant food fields are applied to, long use will not produce side effect.
Specific embodiment
With reference to specific embodiment, the present invention will be further described.
A kind of preventing decayed tooth health-care sweets containing lactoferrin of embodiment 1, by the material composition of following parts by weight：
40 parts of lactoferrin, 5 parts of lysozyme, 5 parts of lactoperoxidase, 7 parts of FOS, 8 parts of Tea Polyphenols, microcrystalline cellulose 4
Part, 1 part of magnesium stearate, 2 parts of amylum pregelatinisatum, 5 parts of starch slurry, 3 parts of dried starch, 20 parts of fruit powder.
Preparation process：To prepare 1000, as a example by average piece weight 0.25g.
（1）Supplementary material prepares：By 40 parts of lactoferrin, 5 parts of lysozyme, 5 parts of lactoperoxidase, 7 parts of FOS, tea
4 parts of 8 parts of polyphenol and microcrystalline cellulose cross 80 mesh sieves after crushing, in proportion precise, are placed in YB series oscillating granulators and mix
Close；
（2）Granulation：By step（1）Resulting material is placed in mixed at high speed comminutor, adds 2 parts of amylum pregelatinisatum, 5 parts of starch slurry
With 3 parts of dried starch, mixed at high speed uniform wet granular；
（3）Dry：Wet granular is transferred in vacuum drying chamber and is dried, it is 50～60 DEG C to arrange EAT, vacuum
0.075-0.09MPa, drying time about 15～30min, with 16 mesh sieve whole grains after, be laid in stainless steel disc, thickness is less than
3cm.It is placed in vacuum drying chamber, dries to pellet moisture and answer≤3%；
（4）Whole grain：Dried particle is placed in pelletizing machine and crosses 16 mesh nylon mesh whole grains；
（5）Total mixing：Particle after by whole grain is moved into and is mixed in YB series oscillating granulators；Add 20 parts of fruit powder and stearic acid
1 part of magnesium, machines, is well mixed, and moisture is surveyed in then sampling；
（6）Compressing tablet：According to the average piece weight of particle, from die needed, compressing tablet in rotary tablet machine is put；
（7）Packaging：Packed from appropriate packing machine, it is desirable to seal, airtight, attractive packages, complete, that is, produced
Preventing decayed tooth health-care sweets of the product containing lactoferrin.
2 lactoferrin of embodiment, lysozyme, the antibacterial experiment in vitro of active ingredient compositions
1. bacterial classification is selected：Streptococcus mutans and lactobacillus acidophilus.
2. activation culture is carried out 2 kinds for trying bacterium from broth bouillon, activated with transfer needle picking on a small quantity respectively
Be put in the triangular flask equipped with sterilized water for examination bacterium mycelium, vibration shakes up, and makes a series of bacteria suspensions, and with cell count
Plate determines that bacteria suspension concentration is about 107-108Cfu/mL, standby.
3. qualitative filter paper is processed into the circular filter paper piece of a diameter of 6mm, is put in dry plate after hot air sterilization, point
Not Jin Ru the lactoferrin of variable concentrations, lysozyme, active ingredient compositions solution, soak 30min.
4. pour into after dissolve sterilized solid medium in culture dish, after culture medium solidifies completely, use pipettor
Draw flat board is accessed for examination bacteria suspension, and uniform to be coated with rod coating.The filter paper that sample test liquid is soaked with aseptic nipper gripping
Piece, at certain intervals distance be gently attached on flat board containing bacterium, and with being soaked with the filter paper of sterilized water as blank control group, every kind of bacterium
3 parallel.Then the flat board for completing it has been inoculated with and has been inverted in the incubator of preference temperature and cultivated, has been cultivated suitable time
Afterwards, take out, measure inhibition zone size.
5. minimal inhibitory concentration（MIC）Determination：The lactoferrin of configuration variable concentrations, lysozyme, active ingredient combinations
Thing solution determines the diameter of inhibition zone according to step method 4..
Diameter ＞ 15mm are extremely sensitive, and diameter is sensitive between 10-15mm, and diameter is less sensitive between 7-9mm.
6. minimum bacteriocidal concentration（MBC）Determination：The lactoferrin of configuration variable concentrations, lysozyme, active component group
Polymer solution observes the size of inhibition zone according to above method 4., it is ensured which does not significantly grow.
7. experimental result：
1 lactoferrin of table is to streptococcus mutans and the bacteriostatic test of lactobacillus acidophilus
Note："+" indicates that bacterial growth "-" is indicated without bacterial growth
2 lysozyme of table is to streptococcus mutans and the bacteriostatic test of lactobacillus acidophilus
Note："+" indicates that bacterial growth "-" is indicated without bacterial growth
3 active ingredient compositions of table are to streptococcus mutans and the bacteriostatic test of lactobacillus acidophilus
Note："+" indicates that bacterial growth "-" is indicated without bacterial growth
As a result：Single active component lactoferrin or lysozyme have certain antibacterial work to streptococcus mutans and lactobacillus acidophilus
With active ingredient compositions also have between certain bacteriostasis, and each composition to streptococcus mutans and lactobacillus acidophilus and have
Certain synergy.
Embodiment 3 suffers from dental caries children using common candy and the clinical control experiment of health-care sweets.
Select 20 deciduous dental caries patients（Age is 3-5 year）, it is desirable to for not carrying out Caries therapy in nearly 3 months
Patient.Two groups are randomly divided into, per group of 10 people, one group is eaten common candy, is eaten the embodiment of the present invention 1 for one group and is prepared gained preventing decayed tooth health care
Candy, daily one.Subjects saliva's sample is extracted respectively before candy is eaten and after eating candy, 7 days by a definite date, candy was in the oral cavity
The about 2-3 minutes time of chewing.In detection saliva, the content of streptococcus mutans and lactobacillus acidophilus, carries out statistical analysis.Inspection
Survey data as follows：
The content of streptococcus mutans and lactobacillus acidophilus in saliva after common candy taken by table 4
The content of streptococcus mutans and lactobacillus acidophilus in saliva after health-care sweets of the present invention taken by table 5
As a result：Take common candy within continuous 7 days, the content ratio of streptococcus mutans and lactobacillus acidophilus increases before eating candy in oral cavity
44 and 29, after taking the health-care sweets of present invention offer, in oral cavity, the content ratio of streptococcus mutans and lactobacillus acidophilus eats sugar
54 and 50 are reduced before fruit.
Confirm that the candy containing lactoferrin, lysozyme and lactoperoxidase there can be stronger sterilization by the present embodiment
Effect, can kill causes the streptococcus mutans of carious tooth and lactobacillus acidophilus in oral cavity, there is to children caries certain protection to make
With reducing the incidence of carious tooth while candy is eaten.
Claims (3)
1. a kind of preventing decayed tooth health-care sweets containing lactoferrin, it is characterised in that formula rate is as follows by weight：Lactoferrin
30-50 parts, lysozyme 3-10 parts, lactoperoxidase 3-10 parts, FOS 3-10 parts, Tea Polyphenols 3-10 parts, microcrystalline cellulose
Plain 3-6 parts, magnesium stearate 0.5-2 parts, amylum pregelatinisatum 2-5 parts, starch slurry 2-5 parts, dried starch 1-5 parts, fruit powder 1-30 part.
2. the preventing decayed tooth health-care sweets of lactoferrin are contained according to claim 1, it is characterised in that as follows by weight：Newborn iron
40 parts of albumen, 5 parts of lysozyme, 5 parts of lactoperoxidase, 7 parts of FOS, 8 parts of Tea Polyphenols, 4 parts of microcrystalline cellulose, stearic acid
1 part of magnesium, 2 parts of amylum pregelatinisatum, 5 parts of starch slurry, 3 parts of dried starch, 20 parts of fruit powder.
3. the preparation method of the preventing decayed tooth health-care sweets of lactoferrin is contained described in claim 1, it is characterised in that walked by weight
Rapid as follows：
（1）Supplementary material prepares：By lactoferrin 30-50 parts, lysozyme 3-10 parts, lactoperoxidase 3-10 parts, FOS
3-10 parts, Tea Polyphenols 3-10 parts, microcrystalline cellulose 3-6 parts cross 80 mesh sieves after crushing, and are placed in granulator in proportion after precise
Middle mixing；
（2）Granulation：By step（1）Resulting material is placed in comminutor and continuously adds amylum pregelatinisatum 2-5 parts, starch slurry 2-5 parts
With dried starch 1-5 parts, it is well mixed, obtains wet granular；
（3）Dry：By step（2）Gained wet granular is transferred in vacuum drying chamber and dries, and it is 50-60 DEG C to arrange EAT,
Vacuum 0.075-0.09MPa, drying time 15-30min, with 16 mesh sieve whole grains after, be laid in stainless steel disc, thickness does not surpass
Cross 3cm；Continue to be placed in vacuum drying chamber, dry to pellet moisture≤3%；
（4）Whole grain：By step（3）Dried particle is placed in pelletizing machine crosses 16 mesh nylon mesh whole grains；
（5）Total mixing：By step（4）Particle after gained whole grain is moved in granulator and is mixed；Add fruit powder 1-30 part and tristearin
Sour magnesium 0.5-2 parts, machine, are well mixed, and moisture is surveyed in then sampling；
（6）Compressing tablet：According to the average piece weight of particle, from die needed, compressing tablet in rotary tablet machine is put；
（7）Packaging：Packed from appropriate packing machine, it is desirable to seal, airtight, attractive packages, complete, that is, produced
Preventing decayed tooth health-care sweets of the product containing lactoferrin.
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| CN201610949112.0A CN106490285A (en) | 2016-11-03 | 2016-11-03 | A kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610949112.0A CN106490285A (en) | 2016-11-03 | 2016-11-03 | A kind of preventing decayed tooth health-care sweets containing lactoferrin and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107712245A (en) * | 2017-11-22 | 2018-02-23 | 东莞亿智食品有限公司 | A kind of low sugar health care candy and preparation method thereof |
| CN109965066A (en) * | 2019-04-16 | 2019-07-05 | 广东亿超生物科技有限公司 | A kind of sandwich gel candy of the fortification of high protein and preparation method thereof |
| WO2019208699A1 (en) * | 2018-04-27 | 2019-10-31 | ライオン株式会社 | Agent for improving bacterial flora in oral cavity and oral composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318314A (en) * | 2000-04-17 | 2001-10-24 | 林桂良 | Gum-based candy containing lysozyme and its production process |
| CN104920774A (en) * | 2015-07-14 | 2015-09-23 | 界首市兆龙食品有限公司 | Enzyme supplementation gum |
-
2016
- 2016-11-03 CN CN201610949112.0A patent/CN106490285A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318314A (en) * | 2000-04-17 | 2001-10-24 | 林桂良 | Gum-based candy containing lysozyme and its production process |
| CN104920774A (en) * | 2015-07-14 | 2015-09-23 | 界首市兆龙食品有限公司 | Enzyme supplementation gum |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107712245A (en) * | 2017-11-22 | 2018-02-23 | 东莞亿智食品有限公司 | A kind of low sugar health care candy and preparation method thereof |
| WO2019208699A1 (en) * | 2018-04-27 | 2019-10-31 | ライオン株式会社 | Agent for improving bacterial flora in oral cavity and oral composition |
| JPWO2019208699A1 (en) * | 2018-04-27 | 2021-05-27 | ライオン株式会社 | Oral flora improver and oral composition |
| JP7351296B2 (en) | 2018-04-27 | 2023-09-27 | ライオン株式会社 | Oral flora improving agent and oral composition |
| CN109965066A (en) * | 2019-04-16 | 2019-07-05 | 广东亿超生物科技有限公司 | A kind of sandwich gel candy of the fortification of high protein and preparation method thereof |
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Application publication date: 20170315 |