CN106458881A - 类胡萝卜素衍生物、其药学上可接受的盐或者其药学上可接受的酯类或酰胺类 - Google Patents
类胡萝卜素衍生物、其药学上可接受的盐或者其药学上可接受的酯类或酰胺类 Download PDFInfo
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- CN106458881A CN106458881A CN201580026006.9A CN201580026006A CN106458881A CN 106458881 A CN106458881 A CN 106458881A CN 201580026006 A CN201580026006 A CN 201580026006A CN 106458881 A CN106458881 A CN 106458881A
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- 239000007962 solid dispersion Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
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- 229910052567 struvite Inorganic materials 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 125000003375 sulfoxide group Chemical group 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- UVZICZIVKIMRNE-UHFFFAOYSA-N thiodiacetic acid Chemical compound OC(=O)CSCC(O)=O UVZICZIVKIMRNE-UHFFFAOYSA-N 0.000 description 1
- NJRXVEJTAYWCQJ-UHFFFAOYSA-N thiomalic acid Chemical compound OC(=O)CC(S)C(O)=O NJRXVEJTAYWCQJ-UHFFFAOYSA-N 0.000 description 1
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- 239000011732 tocopherol Substances 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
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- SBUXRMKDJWEXRL-ZWKOTPCHSA-N trans-body Chemical compound O=C([C@@H]1N(C2=O)[C@H](C3=C(C4=CC=CC=C4N3)C1)CC)N2C1=CC=C(F)C=C1 SBUXRMKDJWEXRL-ZWKOTPCHSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 208000023577 vascular insufficiency disease Diseases 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 1
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- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
R1D2 | -CO-A′-B-D | -CO-E′-F | -CO-G′ | -CO-A′-B-D | -CO-E′-F | -CO-G′ |
R2D2 | -CO-A′-B-D | -CO-E′-F | -CO-G′ | H | H | H |
(XXIV) | (XXV) | ((XXVI) | (XXVII) | (XXVIII) | (XXIX) |
化合物 | 水层比例[%] |
(A)虾青素 | 0.0 |
(B)虾青素二琥珀酸酯 | 43.8 |
(C)实施例(1)的化合物 | 99.7 |
(D)实施例(2)的化合物 | 90.8 |
(E)实施例(4)的化合物 | 100.0 |
(F)实施例(8)的化合物 | 100.0 |
(G)实施例(9)的化合物 | 98.3 |
(H)实施例(10)的化合物 | 100.0 |
Claims (40)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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JP2014104480 | 2014-05-20 | ||
JP2014-104480 | 2014-05-20 | ||
JP2014-247549 | 2014-12-08 | ||
JP2014247549 | 2014-12-08 | ||
PCT/JP2015/064408 WO2015178404A1 (ja) | 2014-05-20 | 2015-05-20 | カロテノイド誘導体、その薬学上許容される塩又はその薬学上許容されるエステル類若しくはアミド類 |
Publications (2)
Publication Number | Publication Date |
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CN106458881A true CN106458881A (zh) | 2017-02-22 |
CN106458881B CN106458881B (zh) | 2019-07-30 |
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CN201580026006.9A Expired - Fee Related CN106458881B (zh) | 2014-05-20 | 2015-05-20 | 类胡萝卜素衍生物、其药学上可接受的盐或者其药学上可接受的酯类或酰胺类 |
Country Status (18)
Country | Link |
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US (1) | US10125104B2 (zh) |
EP (1) | EP3147279A4 (zh) |
JP (1) | JP6393754B2 (zh) |
KR (1) | KR101963946B1 (zh) |
CN (1) | CN106458881B (zh) |
AU (1) | AU2015262405B2 (zh) |
CA (1) | CA2948605C (zh) |
CL (1) | CL2016002940A1 (zh) |
HK (1) | HK1231459A1 (zh) |
IL (1) | IL248700B (zh) |
MX (1) | MX363918B (zh) |
NZ (1) | NZ726535A (zh) |
PH (1) | PH12016502303A1 (zh) |
RU (1) | RU2693455C2 (zh) |
SG (1) | SG11201609405VA (zh) |
TW (1) | TWI654171B (zh) |
WO (1) | WO2015178404A1 (zh) |
ZA (1) | ZA201607968B (zh) |
Cited By (3)
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CN111727039A (zh) * | 2018-02-13 | 2020-09-29 | 阿斯塔制药有限公司 | 大肠炎改善剂 |
CN118063368A (zh) * | 2024-04-22 | 2024-05-24 | 潍坊富邦药业有限公司 | 一种水溶性虾青素衍生物及其合成方法 |
CN118084755A (zh) * | 2024-04-22 | 2024-05-28 | 潍坊富邦药业有限公司 | 一种高水溶性虾青素衍生物及制备方法 |
Families Citing this family (9)
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CN105461696B (zh) * | 2015-12-08 | 2017-11-24 | 李秋菊 | 一种用于脑梗塞康复的药物组合物 |
JP2021008404A (ja) * | 2017-09-27 | 2021-01-28 | アスタファーマシューティカルズ株式会社 | 変形性関節症改善剤 |
JP2021028295A (ja) * | 2017-11-27 | 2021-02-25 | アスタファーマシューティカルズ株式会社 | 光学活性のトランス−アスタキサンチン誘導体又はその塩、及びそれらの化合物を含有する組成物 |
JP2021028301A (ja) * | 2017-12-04 | 2021-02-25 | アスタファーマシューティカルズ株式会社 | 皮膚炎治療剤 |
JP2021028300A (ja) * | 2017-12-04 | 2021-02-25 | アスタファーマシューティカルズ株式会社 | 掻痒抑制剤 |
JP2021054718A (ja) * | 2018-01-09 | 2021-04-08 | アスタファーマシューティカルズ株式会社 | ドライアイ改善剤 |
EP3801496A4 (en) | 2018-06-05 | 2022-07-06 | Flagship Pioneering Innovations V, Inc. | ACTIVE AGENTS AND METHODS OF USE THEREOF FOR TREATING METABOLIC DISORDERS AND NAFLD |
JP2021176821A (ja) * | 2018-08-01 | 2021-11-11 | アスタファーマシューティカルズ株式会社 | 新規カロテノイド関連誘導体、その塩又はエステル類若しくはアミド類 |
KR20220088706A (ko) * | 2019-09-27 | 2022-06-28 | 카닥스 아이엔씨 | 아스타잔틴 에스테르 및 이의 사용 방법 |
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CN118084755A (zh) * | 2024-04-22 | 2024-05-28 | 潍坊富邦药业有限公司 | 一种高水溶性虾青素衍生物及制备方法 |
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KR101963946B1 (ko) | 2019-03-29 |
RU2016149777A (ru) | 2018-06-21 |
MX363918B (es) | 2019-04-05 |
HK1231459A1 (zh) | 2017-12-22 |
JP6393754B2 (ja) | 2018-09-19 |
MX2016015236A (es) | 2017-02-23 |
CA2948605C (en) | 2019-12-24 |
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AU2015262405B2 (en) | 2019-01-03 |
US10125104B2 (en) | 2018-11-13 |
PH12016502303B1 (en) | 2017-02-13 |
EP3147279A4 (en) | 2018-01-10 |
SG11201609405VA (en) | 2016-12-29 |
KR20170007304A (ko) | 2017-01-18 |
US20170081289A1 (en) | 2017-03-23 |
WO2015178404A1 (ja) | 2015-11-26 |
EP3147279A1 (en) | 2017-03-29 |
AU2015262405A1 (en) | 2016-12-08 |
CN106458881B (zh) | 2019-07-30 |
IL248700A0 (en) | 2017-01-31 |
RU2693455C2 (ru) | 2019-07-03 |
PH12016502303A1 (en) | 2017-02-13 |
IL248700B (en) | 2019-06-30 |
CA2948605A1 (en) | 2015-11-26 |
TW201625521A (zh) | 2016-07-16 |
NZ726535A (en) | 2019-02-22 |
JPWO2015178404A1 (ja) | 2017-04-20 |
RU2016149777A3 (zh) | 2018-12-28 |
TWI654171B (zh) | 2019-03-21 |
ZA201607968B (en) | 2018-05-30 |
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