CN106421103A - Chinese medicinal formula for curing chicken colibacillosis - Google Patents

Chinese medicinal formula for curing chicken colibacillosis Download PDF

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CN106421103A
CN106421103A CN201611161598.8A CN201611161598A CN106421103A CN 106421103 A CN106421103 A CN 106421103A CN 201611161598 A CN201611161598 A CN 201611161598A CN 106421103 A CN106421103 A CN 106421103A
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radix
chinese medicinal
chicken colibacillosis
chicken
medicinal formulae
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王宇
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Wanyuan City Hengkang Agricultural Development Co Ltd
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Wanyuan City Hengkang Agricultural Development Co Ltd
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a Chinese medicinal formula for curing chicken colibacillosis. The Chinese medicinal formula comprises the following raw materials in percentage by weight: 14-16% of golden cypress, 14-16% of radix scutellariae, 14-16% of Chinese pulsatilla root, 14-16% of radix puerariae, 9.5-10.5% of rhizoma atractylodis, 9.5-10.5% of pericarpium citri reticulatae, 7-8% of herba andrographitis, 7-8% of radix rehmanniae recen, and 4.5-5.5% of liquorice. The pure traditional Chinese medicines are used to cure and prevent chicken colibacillosis, the abuse of antibiotics and the like is effectively avoided, no toxic or side effect is produced, the effect is good, and the cost is low.

Description

One kind treats chicken colibacillosis Chinese medicinal formulae
Technical field
The present invention relates to technical field of Chinese medicines, treats chicken colibacillosis Chinese medicinal formulae in particular to one kind.
Background technology
Chicken colibacillosis are the abbreviations of Escherichia coli, and the antibacterial is widely present in nature, and animal and bird intestines Normal perch bacterium, many bacterial strain no pathogenicities, generally from the escherichia coli described in veterinary's angle, refer to pathogenic bacterium Strain.Nowadays with the intensive manufacture of aquaculture, chicken colibacillosis increasingly become harm poultry husbandry great bacterial diseases it One.Since the 80's of 20th century, with emergence and the development of China's aquaculture, the disease spreads in China various places and spreads, entirely All there is the report that the disease occurs state various places, and the disease is often with the disease such as chronic respiratory tract disease, newcastle, infectious bursa of Fabricius simultaneously Morbidity or secondary disease.As colibacillosiss are also easy to produce drug resistance, very big difficulty is brought to the disease is prevented and treated.Nearly ten years, old institute Black chicken breed purity and intensive culture level are improved constantly, in order to ensure the black chicken of old institute（Egg）Fragrant in taste is fine and smooth, natural richness Selenium, nutritious qualitative characteristics, for a long time, raiser is fed black chicken and is herded with daytime and raises scattered, and night enters house perches and wait slightly The way to manage that puts, but this mode of raising scattered causes the black chicken of old institute easily ehec infection disease, and colibacillosiss are to trouble One of difficult problem of " raising pattern scattered " maximum, in the black chicken cultivation of old institute, morbidity amount is in rising trend in recent years, it has also become harm is old The primary bacterial infectious disease of the black chicken aquaculture of institute.
Primary disease can all occur throughout the year, and coop ventilation at the beginning of You Yidong last month of spring is more multiple when bad.The chicken at various ages Primary disease can be infected, but young chicken most easily occurs.The route of infection have three kinds：One kind is that Disease in Infants hatching egg carries disease germs vertical transmission；Two are Hatching process hatching egg pollution spread is to embryo；Three is that source of disease is invaded by the door such as digestive tract, Xi Hu road, anus, skin trauma Contact transmission.Disease caused by it belongs to opportunistic illnesses category, in the chicken house that feeding and management is not good at, sanitary condition is poor, when When the resistance of chicken reduces, will ehec infection disease.In the good chicken farm of feeding and management and sanitary condition, chicken immunity and Resistance is stronger, and Colibacillosis rate is relatively low, and caused loss is less.
Colibacillary antigen construct complexity, pathogenic serotype is a lot of, it was reported that the existing pathogenic serotype of China Existing kind more than 70, principal causative type is O etc..Due to serotype difference, clinical manifestation and epidemiological features are also different, main table It is now acute sepsis（Perihepatitis, pericarditiss, peritonitis）, chickling omphalitis yolk capsulitis, airsacculitis, enteritis, encephalitis, defeated scorching pipe Inflammation, granuloma, joint of the lower extremity swollen, panophthalmitis of scorching and foot pad etc., can also cause hatching dead germ and weak embryo.
Escherichia coli inactivated vaccine generally includes O1、O2、O78、O35These four common serotype, cause in a chicken farm The bacterial strain of disease often has several serotypes, if them and above-mentioned 4 serotype degree of agreements height, immune effect is preferable, instead The low then immune effect of degree of agreement undesirable, same vaccine is used for different regions, different chicken houses, and effect is variant.At present, The vaccine of domestic production now is limited due to its protective rate, and bacterial strain degree of agreement is not high, and duration of immunity is short, troublesome poeration, is promoting In encounter larger resistance, just make the vaccine production of colibacillosiss encounter a larger difficult problem.From the point of view of putting into practice in recent years, the city Once escherichia coli inactivated vaccine is crossed in immunity for several main Jiu Yuanhei chicken plants, but immune effect effect is poor, and city's model is described The coli strain for enclosing interior chicken farm is low with above-mentioned four kinds of serotype degree of agreements, so many Jiu Yuanhei chicken plants are so far Yet colibacillary epidemic prevention is not listed in immune programme for children.
In the medicine for preventing and treating the black chicken colibacillosis of old institute, it is currently mainly used chemicalses and antibiotic is prevented Control, common antibiotics mainly have：Florfenicol, quinolones, cephalo-type etc., but these medicines are mostly strong, malicious with drug resistance Property larger, the relatively costly, feature of residual weight, in breeding process not science, blindly the phenomenon of abuse antimicrobial drug more serious, some Chemicalses and antibiotic have certain toxicity, side effect, can pass to the mankind by meat, egg, bring very to food hygiene Big problem.Due to a large amount of uses of chemicalses and antibiotic, make colibacillary drug tolerance of strain more and more stronger, Antibiotic Resistance Also increasingly wider, some coli strains even to not yet for veterinary clinic new antibiotic also show very strong resistance to The property of medicine.And the increase with drug resistance, some chemical drugss are difficult to control to the state of an illness, not only cause drug waste, but also prolong The state of an illness, causes very big economic loss to raiser by mistake, and people have to seek damage of the new means of prevention to control the disease Evil.
Content of the invention
For the problems referred to above, the present invention proposes one kind and treats chicken colibacillosis Chinese medicinal formulae, using Chinese medicine preparation, has Effect treatment chicken colibacillosis, and have no toxic side effect.
To achieve these goals, the technical solution adopted in the present invention is, one kind treats chicken colibacillosis prescription Agent, its raw materials by weight is calculated as：Cortex Phellodendri 14～16%, Radix Scutellariae 14～16%, the Radix Pulsatillae 14～16%, Radix Puerariae 14～16%, Rhizoma Atractylodis 9.5～10.5%, Pericarpium Citri Reticulatae 9.5～10.5%, Herba Andrographis 7～8%, Radix Rehmanniae 7～8%, Radix Glycyrrhizae 4.5～5.5%.
Preferably, one kind treats chicken colibacillosis Chinese medicinal formulae, its raw materials by weight is calculated as：Cortex Phellodendri 15%, Radix Scutellariae 15%, the Radix Pulsatillae 15%, Radix Puerariae 15%, Rhizoma Atractylodis 10%, Pericarpium Citri Reticulatae 10%, Herba Andrographis 7.5%, Radix Rehmanniae 7.5%, Radix Glycyrrhizae 5%.
Preferably, in raw material, by weight, Cortex Phellodendri:Radix Scutellariae=1:1.
Preferably, in raw material, by weight, the Radix Pulsatillae:Radix Puerariae=1:1.
Further, described one kind treats chicken colibacillosis Chinese medicinal formulae, is 0.5～5g per only chicken consumption.
Preferably, described one kind treats chicken colibacillosis Chinese medicinal formulae, it is 1～2.5g/ days per only chicken consumption.
Further, described one kind treats chicken colibacillosis Chinese medicinal formulae, is used in mixed way in feedstuff by adding.
Further, by proportion compatibility, 100 mesh sieves are crossed after crushing, adds water to cook twice, collecting decoction, after concentrated medicament, Add in the drinking water of chicken.
Preferably, this prescription proportion compatibility is pressed, 100 mesh sieves are crossed after crushing, add water to cook twice, collecting decoction, dense Shorten medicinal liquid of every 1mL containing 1g crude drug into, after medicinal liquid dilution, supply whole day drinking-water.
The present invention treats chicken colibacillosis using Chinese herbal medicine compatibility, has no toxic side effect, good drug efficacy, effectively can prevent and Treatment chicken colibacillosis, while the resistivity of chicken is lifted, and reagent cost is cheap.
In raw material, it is Rhizoma Atractylodis, Radix Puerariae, Pericarpium Citri Reticulatae that monarch drug is Cortex Phellodendri, Radix Scutellariae, the Radix Pulsatillae, ministerial drug, and Herba Andrographis, Radix Rehmanniae are assistant Medicine, makes medicine for Radix Glycyrrhizae.
Cortex Phellodendri：With broad-spectrum antibacterial action, to escherichia coli, S. aureus L-forms, etc. all have stronger inhibitory or killing effect, for heat clearing away Dampness, eliminating fire and detoxication, also certain stomach invigorating, function of gallbladder promoting, diuresis, being apt to damp-heat in lower-JIAO is driven, is dysentery to be controlled in key medicine.Though Cortex Phellodendri So effect is slightly below Rhizoma Coptidis, but its price 12-18 unit/kilogram.
Radix Scutellariae：Containing Radix Scutellariae element, Radix Scutellariae glycoside, have functions that heat clearing away, dampness, only removing toxic substances, intestinal bleeding, to streptococcus, gold Portugal bacterium, escherichia coli, bacillus pyocyaneus etc. all have inhibitory or killing effect, the work(with Cortex Phellodendri prescription with collaboration, potentiation.
The Radix Pulsatillae：With heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, to dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, golden yellow Fructus Vitis viniferae Coccus, escherichia coli and influenza virus etc. all have inhibitory action, for hygropyretic dysentery or fulminant dysentery, also have convergence to gastrointestinal mucosa And anastalsis, especially good to dysentery effect, and price 18-25 unit/kilogram.
Radix Puerariae：Have functions that expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, Shengyang Zhixie, control the exterior syndrome of affection due to external wind and heat, can with Rhizoma Coptidis, Radix Scutellariae, Radix Glycyrrhizae equivalent are used.
Rhizoma Atractylodis：With rheumatism, drying damp and strengthening spleen effect, also significantly row's potassium, sodium effect, acts on shield kidney, and The heat clearing and damp drying effect of Cortex Phellodendri can be strengthened, as the accessory drugss of Cortex Phellodendri.
Pericarpium Citri Reticulatae：Spleen invigorating qi-regulating, the work(of bath humidifying expectorant, Li Shizhen (1518-1593 A.D.) is thought：" Pericarpium Citri tangerinae hardship can rush down can dry pungent energy dissipate, wet energy and, its All kinds of diseases and ailments are controlled, the work(of qi-regulating dampness are always taken, is then mended with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then drop with drop medicine ", it is seen that old Skin is used to be made with assistant and different, and Pericarpium Citri Reticulatae low price.
Radix Glycyrrhizae：With invigorating middle warmer and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the property of medicine is relaxed, is had to anti-acetylcholine Effect.This prescription is used as coordinating the actions of various ingredients in a prescription.
Specific embodiment
Below by specific embodiment, the present invention is described in further detail.
Embodiment 1：One kind treats chicken colibacillosis Chinese medicinal formulae, and its raw materials by weight is calculated as：Cortex Phellodendri 15%, Radix Scutellariae 15%, the Radix Pulsatillae 15%, Radix Puerariae 15%, Rhizoma Atractylodis 10%, Pericarpium Citri Reticulatae 10%, Herba Andrographis 7.5%, Radix Rehmanniae 7.5%, Radix Glycyrrhizae 5%.The Chinese medicine Used in prescription adds feedstuff, 0.5～5g/ of average whole day dosage is only.
1-8 cage being chosen, 50 50 age in days chickens being grown per cage, 1-4 cage uses Chinese medicinal formulae of the present invention, averagely Whole day dosage（G/ is only）Respectively 0.5,1,1.5,2,5-8 cage is respectively using ofloxacin, florfenicol, ceftiofur Sodium, colistin, average whole day dosage is only 0.3g/, after continuously raising 20, obtains following table.（Wherein Chinese medicine formula 44 yuan/kilogram, 300 yuan/kilogram of ofloxacin, 500 yuan/kilogram of florfenicol, 800 yuan/kilogram of ceftiofur sodium, colistin 400 yuan/kilogram；）
Embodiment 2：One kind treats chicken colibacillosis Chinese medicinal formulae, and its raw materials by weight is calculated as：Cortex Phellodendri 14%, Radix Scutellariae 14%th, the Radix Pulsatillae 16%, Radix Puerariae 16%, Rhizoma Atractylodis 10.5%, Pericarpium Citri Reticulatae 9.5%, Herba Andrographis 8%, Radix Rehmanniae 7.5%, Radix Glycyrrhizae 4.5%.The Chinese medicine Used in prescription adds feedstuff, 1～2.5g/ of average whole day dosage is only.
Embodiment 3：One kind treats chicken colibacillosis Chinese medicinal formulae, and its raw materials by weight is calculated as：Cortex Phellodendri 14%, Radix Scutellariae 16%, the Radix Pulsatillae 16%, Radix Puerariae 14%, 10 % of Rhizoma Atractylodis, Pericarpium Citri Reticulatae 10%, Herba Andrographis 7.5%, Radix Rehmanniae 7.5%, Radix Glycyrrhizae 5%.In this Used in prescription agent adds feedstuff, 2.5～5g/ of average whole day dosage is only.
Embodiment 4：, one kind treats chicken colibacillosis Chinese medicinal formulae, and its raw materials by weight is calculated as：Cortex Phellodendri 16%, Radix Scutellariae 16%, the Radix Pulsatillae 14%, Radix Puerariae 14%, Rhizoma Atractylodis 9.5%, Pericarpium Citri Reticulatae 10.5%, Herba Andrographis 7%, Radix Rehmanniae 8%, Radix Glycyrrhizae 5%.By compatibility Ratio, crosses 100 mesh sieves after crushing, adds water to cook twice, collecting decoction, after concentrated medicament, adds in the drinking water of chicken.
Embodiment 5：One kind treats chicken colibacillosis Chinese medicinal formulae, and its raw materials by weight is calculated as：Cortex Phellodendri 15%, Radix Scutellariae 15%, the Radix Pulsatillae 15%, Radix Puerariae 15%, Rhizoma Atractylodis 10%, Pericarpium Citri Reticulatae 10%, Herba Andrographis 7.5%, Radix Rehmanniae 7%, Radix Glycyrrhizae 5.5%.By we Agent proportion compatibility is combined into 10 kilograms.100 mesh sieves are crossed after crushing, add water to cook twice, collecting decoction, be condensed into every 1mL Medicinal liquid containing 1g crude drug, supplies whole day drinking-water after medicinal liquid dilution.
The preferred embodiments of the present invention are the foregoing is only, the present invention is not limited to, for the skill of this area For art personnel, can there are various modifications and variations in the spirit and principles in the present invention, the modification of these equivalents or replacement etc., It is all contained within protection scope of the present invention.

Claims (9)

1. one kind treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that its raw materials by weight is calculated as：Cortex Phellodendri 14～ 16%th, Radix Scutellariae 14～16%, the Radix Pulsatillae 14～16%, Radix Puerariae 14～16%, Rhizoma Atractylodis 9.5～10.5%, Pericarpium Citri Reticulatae 9.5～10.5%, punching Lotus 7～8%, Radix Rehmanniae 7～8%, Radix Glycyrrhizae 4.5～5.5%.
2. one kind according to claim 1 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that its raw material is by weight Percentages are：Cortex Phellodendri 15%, Radix Scutellariae 15%, the Radix Pulsatillae 15%, Radix Puerariae 15%, Rhizoma Atractylodis 10%, Pericarpium Citri Reticulatae 10%, the Herba Andrographis 7.5%, Radix Rehmanniae Yellow 7.5%, Radix Glycyrrhizae 5%.
3. one kind according to claim 1 and 2 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：In raw material, press Weight portion meter, Cortex Phellodendri:Radix Scutellariae=1:1.
4. one kind according to claim 1 and 2 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：In raw material, press Weight portion meter, the Radix Pulsatillae:Radix Puerariae=1:1.
5. one kind according to claim 1 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：Per only chicken consumption it is 0.5～5g/ days.
6. one kind according to claim 5 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：Per only chicken consumption it is 1～2.5g/ days.
7. one kind according to claim 1 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：By adding feedstuff In be used in mixed way.
8. one kind according to claim 1 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：By proportion compatibility, 100 mesh sieves are crossed after crushing, add water to cook twice, collecting decoction, after concentrated medicament, add in the drinking water of chicken.
9. one kind according to claim 8 treats chicken colibacillosis Chinese medicinal formulae, it is characterised in that：Described medicinal liquid is dense Medicinal liquid after contracting, per 1mL containing 1g crude drug.
CN201611161598.8A 2016-12-15 2016-12-15 Chinese medicinal formula for curing chicken colibacillosis Pending CN106421103A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111658706A (en) * 2020-06-24 2020-09-15 天津九州大地饲料有限公司 Traditional Chinese medicine additive for feed, preparation method and feed

Citations (3)

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CN1380098A (en) * 2002-05-20 2002-11-20 张勇飞 Anti-infection compound preparation and its preparation method
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CN1380098A (en) * 2002-05-20 2002-11-20 张勇飞 Anti-infection compound preparation and its preparation method
CN101209305A (en) * 2006-12-25 2008-07-02 天津市润拓生物技术有限公司 Chinese medicinal oral liquid for treating colibacillosis of avian
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Application publication date: 20170222