CN104644742A - Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating infectious rhinitis of chicken and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 15-25 parts of dahurian angelica root, 5-15 parts of honeysuckle, 1-10 parts of isatis root, 1-10 parts of radix scutellariae, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of cocklebur fruit, 10-20 parts of rhizoma atractylodis and 1-10 parts of licorice root. The traditional Chinese medicine composition has effects of resisting bacteria, diminishing inflammation, eliminating swelling and relieving pain, has small toxic or side effect, does not produce drug residue, is convenient for use, does not cause resistance to the drug easily, can be absorbed easily, has high bioavailability, satisfies veterinary drug and animal-derived food safety requirements and is an ideal traditional Chinese medicine composition for treating infectious rhinitis of chicken.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine composition for the treatment of infectious coryza of chicken and preparation method thereof.
Background technology
Infectious coryza of chicken is the chicken respiratory bacterial infectious disease caused by Haemohpilus paragallinaram, and main manifestations is respiratory mucosa inflammation, incidence swelling, conjunctivitis, often betide Growing Chicken and laying hen group, morbidity chicken growth promoter is obstructed, poor growth, mortality increases, laying rate significantly declines, and concurrent influenza or newcastle, can cause feed intake sharply to decline simultaneously, severe infections person is dead, the economic development of serious threat chicken house.This is sick is multiplely born in cold season, causes the main cause of this disease to be feeding and management low SI.Due to covering by the deadly infectious disease such as newcastle, bird flu, this sick mortality rate is relatively not high, and infectious coryza of chicken is ignored, many chicken houses, particularly individual raiser fails to carry out vaccination prevention, causes this disease to happen occasionally, causes very large economic loss to plant.
Be used alone antibiotic and can not effect a radical cure infectious coryza of chicken, and the accumulations such as the antibiotic in the product such as meat, egg of poultry can be caused residual, be detrimental to health, therefore, the control bacterial disease good effect such as infectious coryza of chicken and non-harmful medicine are more and more welcome by society.Chinese herbal and crude drugs preparations can disease therapy, growth promoting effects, improve fertility performance, and life-time service toxic and side effects is very micro-, not easily develops immunity to drugs, and noresidue, therefore, Chinese herbal and crude drugs preparations has natural advantage in infectious coryza of chicken therapeutic process.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of infectious coryza of chicken.The present invention has effect of antibacterial, antiinflammatory, detumescence, pain relieving, and toxic and side effects is little, drug residue free, easy to use, not easily produces drug resistance, easily absorbs, and bioavailability is high.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of infectious coryza of chicken.
The present invention is achieved by the following technical solutions:
Treat a Chinese medicine composition for infectious coryza of chicken, component and the ratio of weight and number thereof of its Chinese medicine composition are respectively:
Treat a preparation method for the Chinese medicine composition of infectious coryza of chicken, the step of its preparation method is as follows:
(1) take the Radix Angelicae Dahuricae, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae powder respectively according to weight proportion and be broken into powder, and respectively all by 80 mesh sieves;
(2) Radix Angelicae Dahuricae after sieving in step (1), Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the infectious coryza of chicken that namely obtains medical treatment.
Advantage of the present invention and beneficial effect are:
The Radix Angelicae Dahuricae contained in the Chinese medicine composition of 1, this treatment infectious coryza of chicken, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, the Chinese medicinal ingredients such as Rhizoma Atractylodis and Radix Glycyrrhizae, to the infectious coryza of chicken that Haemohpilus paragallinaram causes, there is good preventive and therapeutic effect, antibacterial action successful.
2, the Chinese medicine composition has a broad antifungal spectrum of this treatment infectious coryza of chicken, does not affect by temperature and acid-base value, steady quality, easily absorbs, easy to use, effective, can reach blood peak concentration of drug within a short period of time with extremely low concentration.
3, the present invention has effect of antibacterial, antiinflammatory, detumescence, pain relieving, toxic and side effects is little, drug residue free, easy to use, not easily produce drug resistance, easily absorb, bioavailability is high, meeting safe veterinary drug, ensure the requirement of animal-derived food safety, is a kind of Chinese medicine composition of ideal treatment infectious coryza of chicken.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
The Radix Angelicae Dahuricae involved in the present invention, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae all commercially can be bought and obtain.
Embodiment 1
Treat a Chinese medicine composition for infectious coryza of chicken, component and the weight thereof of its Chinese medicine composition are respectively: Radix Angelicae Dahuricae 25g; Flos Lonicerae 15g; Baphicacanthus cusia 10g; Radix Scutellariae 10g; Radix Saposhnikoviae 20g; Fructus Xanthii 20g; Rhizoma Atractylodis 20g; Radix Glycyrrhizae 10g.
Treat a preparation method for the Chinese medicine composition of infectious coryza of chicken, the step of its preparation method is as follows:
(1) take the Radix Angelicae Dahuricae, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae powder respectively according to weight proportion and be broken into powder, and respectively all by 80 mesh sieves;
(2) Radix Angelicae Dahuricae after sieving in step (1), Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the infectious coryza of chicken that namely obtains medical treatment.
Embodiment 2
Treat a Chinese medicine composition for infectious coryza of chicken, component and the weight thereof of its Chinese medicine composition are respectively: Radix Angelicae Dahuricae 20g; Flos Lonicerae 10g; Radix Isatidis 5g; Radix Scutellariae 5g; Radix Saposhnikoviae 15g; Fructus Xanthii 15g; Rhizoma Atractylodis 15g; Radix Glycyrrhizae 5g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat a Chinese medicine composition for infectious coryza of chicken, component and the weight thereof of its Chinese medicine composition are respectively: Radix Angelicae Dahuricae 15g; Flos Lonicerae 5g; Radix Isatidis 1g; Radix Scutellariae 1g; Radix Saposhnikoviae 10g; Fructus Xanthii 10g; Rhizoma Atractylodis 10g; Radix Glycyrrhizae 1g.
The step of its preparation method is with embodiment 1.
Embodiment 4
Treat a Chinese medicine composition for infectious coryza of chicken, component and the weight thereof of its Chinese medicine composition are respectively: Radix Angelicae Dahuricae 20g; Flos Lonicerae 15g; Radix Isatidis 5g; Radix Scutellariae 8g; Radix Saposhnikoviae 18g; Fructus Xanthii 12g; Rhizoma Atractylodis 16g; Radix Glycyrrhizae 6g.
The step of its preparation method is with embodiment 1.
Clinical practice
In order to verify the clinical therapeutic efficacy of the present invention to infectious coryza of chicken, we have carried out the clinical trial of the present invention to infectious coryza of chicken in the cultivation factory of certain infected chicken infective rhinitis of Dezhou City Shandong Province.The present invention is divided into basic, normal, high three dosage to carry out grouping administration to animal by test, compares, thus evaluate therapeutic effect of the present invention and optimum amount with the therapeutic effect of the conventional treatment drug of infectious coryza of chicken.
1, materials and methods
1.1 experimental animal
There is the chicken house of infectious coryza of chicken in Dezhou City Shandong Province.
1.2 trial drug
The present invention is prepared by our company.
Bar founds health: 100g/ bag, Tianjin Zhonggao Biotechnology Co., Ltd., product batch number * * * * * *
1.3 test method
The case of infectious coryza of chicken is primarily of clinical symptoms, and the methods such as inspection change and bacteria distribution qualification of cuing open are made a definite diagnosis, and then sick chicken random packet are treated by experimenter.
The diagnostic criteria of 1.4 infectious coryza of chickens
Clinical symptoms:
Sick chicken initial symptom is heating, and loss of appetite, flows thin nose liquid, drowsiness, spirit is depressed, falls ill after 3-5 days, nose liquid thickness, form yellow crusts at nostril place, behind blocking nostril, in oral cavity, occur thick liquid, dyspnea, occurring snore and strange cough, occur drawing white, yellow, green loose stool simultaneously, there is the Unilateral edema of the typical disease face of this disease in site morbidity chicken
Cut open inspection change:
Observe cheesy oozing out in nasal sinuses, trachea accumulation mucus or pus, part chicken has slight pneumonia, the eyelid surface crust of teasing swelling, adularescent pus flows out, and has faint yellow gel-shaped to leach under the sick chicken skin of face of face serious swelling, food is not had to accumulate in digestive tract, corpse skeletonize.The organs such as liver, heart, kidney, fabricius bursa and digestive tract do not have obvious pathological changes.
Bacteria distribution is identified:
Get hole secretions under disease clavus, nasal cavity, socket of the eye, smear, microscopy after Gram’s staining, finds that there is gram-negative coccobacillus, and exists in pleomorphism, once in a while in filamentous, has folder film around thalline.
1.5 experimental animal groupings and process
In chicken house, choose the Growing Chicken with infectious coryza of chicken clinical symptoms, and be divided into 5 groups at random, often group is no less than 200.
Testing 1 group is matched group, not administration;
Testing 2 groups is low dose group of the present invention, 1/2 times amount administration of clinical recommended dose (every plumage 0.75g), spice, successive administration 5 days;
Testing 3 groups is dosage group in the present invention, clinical recommended dose (every plumage 1.5g) administration, spice, successive administration 5 days;
Testing 4 groups is high dose group of the present invention, 2 times amount administrations of clinical recommended dose (every plumage 3g), spice, successive administration 5 days;
Testing 5 groups is that bar founds health matched group, uses to specifications: mixed drink, is watered the amount administration of 500kg, successive administration 5 days by 100g.
1.6 therapeutic effect decision methods
Clinical symptom disappearance, cuts open inspection without obvious pathological change, and bacteria distribution qualification does not find gram negative bacteria, is judged to cure.
Cure rate:
Medication postoperative infection chicken clinical symptom disappearance, searches for food, spirit, feces etc. recovers all to be judged as normally curing.The ratio calculating cure rate that this group tests chicken is accounted for according to curing number of elements.
Effective percentage:
The clinical symptom relief such as sick chicken food for waste absolutely, lassitude, abnormal defecation after medication, searches for food, spirit and defecation situation starts to take a turn for the better, be all judged to effectively.The ratio accounting for this group test chicken number of elements according to effective number of elements calculates effective percentage.
Inefficiency:
The symptoms such as after medication, sick chicken food is for waste absolutely, lassitude, feces are abnormal are not still felt any better and are even worsened died, and it is invalid to be all judged as.The ratio accounting for this group test number of elements according to invalid number of elements calculates inefficiency.
1.7 statistical analysis
The percents such as therapeutic effect cure rate, effective percentage represent.Comparison in difference between group adopts X 2 test to analyze.P<0.05 and P<0.01 represents significant difference and extremely remarkable respectively.
2 result of the tests
To the chicken group of natural infection infectious coryza of chicken, give the Chinese medicine composition of the present invention of various dose respectively, after spice, by comparing with matched group, the clinical symptoms of morbidity chicken group obviously alleviates, and body weight significantly increases.Therapeutic effect and the average weight gain of middle dosage group all reach desirable requirement; It is ideal that bar founds health treatment of control group effect, but chicken average weight gain is obviously not as the present invention.The results are shown in Table 1.
Table 1 observation of curative effect
3 interpretations of result
From clinical symptoms, cut open inspection change, effective percentage, inefficiency four aspects analyze, the therapeutic effect of middle dosage group and high dose group apparently higher than other treatment group, wherein with the prevention effect of middle dosage group the best.Bar founds health matched group certain therapeutic effect, but after treatment, the body weight increase of chicken is affected, and economic loss is larger.
4 conclusions
The present invention, by the administration of per kilogram of body weight 1.5g spice, treats the sick chicken suffering from infectious coryza of chicken, to the infectious coryza of chicken Be very effective caused by Haemohpilus paragallinaram for continuous 5 days.
Claims (2)
1. treat a Chinese medicine composition for infectious coryza of chicken, it is characterized in that: component and the ratio of weight and number thereof of this Chinese medicine composition are respectively:
2. a preparation method for the Chinese medicine composition for the treatment of infectious coryza of chicken as claimed in claim 1, is characterized in that: the step of this preparation method is as follows:
(1) take the Radix Angelicae Dahuricae, Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae powder respectively according to weight proportion and be broken into powder, and respectively all by 80 mesh sieves;
(2) Radix Angelicae Dahuricae after sieving in step (1), Flos Lonicerae, Radix Isatidis, Radix Scutellariae, Radix Saposhnikoviae, Fructus Xanthii, Rhizoma Atractylodis and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the infectious coryza of chicken that namely obtains medical treatment.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878720A (en) * | 2016-06-22 | 2016-08-24 | 吴淑芬 | Compound traditional Chinese medicine for treating infectious rhinitis of chicken and preparation method thereof |
| CN107213298A (en) * | 2016-03-22 | 2017-09-29 | 陈伯顺 | A kind of medicine for treating infectious coryza of chicken |
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| CN101461863A (en) * | 2007-12-18 | 2009-06-24 | 上海华篷防爆科技有限公司 | Medicament composition for preventing and treating infectious disease of animal, and preparation method and use thereof |
| CN102846713A (en) * | 2012-09-05 | 2013-01-02 | 河北科技师范学院 | Chinese herbal oral liquid for treating chicken infective rhinitis, and preparation method thereof |
| CN103181970A (en) * | 2011-12-27 | 2013-07-03 | 瑞普（天津）生物药业有限公司 | Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213298A (en) * | 2016-03-22 | 2017-09-29 | 陈伯顺 | A kind of medicine for treating infectious coryza of chicken |
| CN105878720A (en) * | 2016-06-22 | 2016-08-24 | 吴淑芬 | Compound traditional Chinese medicine for treating infectious rhinitis of chicken and preparation method thereof |
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Application publication date: 20150527 |