CN110652543A - Preparation method and application of Chinese herbal medicine preparation for treating live pig viral enteritis - Google Patents
Preparation method and application of Chinese herbal medicine preparation for treating live pig viral enteritis Download PDFInfo
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Abstract
The invention relates to the field of veterinary drugs, in particular to a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis, which comprises the following components in parts by weight: 9-12 parts of fructus forsythiae, 8-10 parts of dandelion, 8-11 parts of honeysuckle, 6-9 parts of mangnolia officinalis, 7-9 parts of fried bitter almond, 5-7 parts of gypsum, 6-8 parts of isatis root, 4-6 parts of lotus petiole, 5-7 parts of houttuynia cordata, 5-7 parts of sanguisorba officinalis, 3-5 parts of coptis chinensis, 2-4 parts of rhodiola rosea, 3-5 parts of fried hawthorn, 3-5 parts of raw liquorice and a proper amount of deionized water; the Chinese herbal medicine preparation for treating the viral enteritis of the live pigs is prepared from the raw materials, can effectively prevent and treat the viral enteritis of the pigs, has no side effect and quick curative effect, can adjust the functions of intestines and stomach and promote the appetite of the pigs, and is simple to prepare and worthy of mass production and use.
Description
Technical Field
The invention relates to the field of veterinary drugs, in particular to a preparation method and application of a Chinese herbal medicine preparation for treating live pig viral enteritis.
Background
Live pigs, i.e. live pigs, are collectively referred to as non-slaughtered domestic pigs, excluding boar pigs. Pigs, omnivorous animals. Pigs generally refer to livestock. The pig is the end of the twelve animals, also known as the helminth. Mammals have fat bodies, short limbs and long noses and mouths. The raw pork can be eaten, the skin can be used for making leather, the body and limbs are short, the nature is warm and domesticated, the adaptability is strong, the raw pork is easy to raise, the propagation is fast, and the raw pork has black, white, dark reddish brown or black and white flowers and other colors. The pigs can be bred in 5-12 months after birth, and the gestation period is about 4 months. The average life span of pigs was 20 years.
The pig often has viral enteritis in the breeding process, and the viral enteritis of the pig is diseases which mainly comprise pig's coronavirus and rotavirus and appear in the symptoms of diarrhea. Is an acute and highly contagious disease. Their clinical manifestations are watery stool, vomiting and dehydration. The disease is mainly developed in spring and winter. After infection of the suckling piglet, the death rate is 100 percent. After the fattening pigs are infected, the death rate is not high, so that the immunity of the organism is reduced, the growth is influenced, and great economic loss is brought to the pig raising industry. The traditional prevention and treatment scheme is to use antibiotics, chemical synthetic drugs, vitamins, trace elements, hormones and vaccines, the vaccines are used for preventing and treating diseases but not for treating diseases, a large amount of antibiotics are used as a new stress source to damage immune functions, reduce immune stress response, accelerate destruction of the immune system of the pigs, weaken the disease resistance and easily infect various diseases. At present, most of the additives used in the market are antibiotics, chemical synthetic drugs, vitamins, trace elements, hormones and the like, so that the aim of preventing and treating diseases is not achieved, drug residues are easily formed in pig products to influence the body health of people, and other diseases are easily induced to cause great economic loss to the pig industry. In the market, the existing medicines for preventing and treating porcine viral enteritis are few, have side effects and slow curative effect, and often cannot play a role in preventing and treating porcine viral enteritis.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a preparation method and application of a Chinese herbal medicine preparation for treating viral enteritis of live pigs, which can effectively prevent and treat the viral enteritis of the pigs, and has no side effect and quick curative effect.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 9-12 parts of fructus forsythiae, 8-10 parts of dandelion, 8-11 parts of honeysuckle, 6-9 parts of mangnolia officinalis, 7-9 parts of fried bitter almond, 5-7 parts of gypsum, 6-8 parts of isatis root, 4-6 parts of lotus petiole, 5-7 parts of houttuynia cordata, 5-7 parts of sanguisorba officinalis, 3-5 parts of coptis chinensis, 2-4 parts of rhodiola rosea, 3-5 parts of fried hawthorn, 3-5 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 65-85 deg.C, respectively pulverizing, and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 10-20min, decocting under stirring, maintaining slightly boiling state for 30-60min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and bagging to obtain Chinese medicinal preparation.
Preferably, the preparation method of the Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 10-11 parts of fructus forsythiae, 9-10 parts of dandelion, 9-11 parts of honeysuckle, 6-8 parts of mangnolia officinalis, 7-8 parts of fried bitter almond, 6-7 parts of gypsum, 6-7 parts of isatis root, 5-6 parts of lotus petiole, 5-6 parts of houttuynia cordata, 6-7 parts of sanguisorba officinalis, 4-5 parts of coptis chinensis, 2-3 parts of rhodiola rosea, 3-4 parts of fried hawthorn, 3-4 parts of raw liquorice and a proper amount of deionized water.
Preferably, the preparation method of the Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 10 parts of fructus forsythiae, 9 parts of dandelion, 9 parts of honeysuckle, 8 parts of mangnolia officinalis, 7 parts of fried bitter almond, 6 parts of gypsum, 7 parts of isatis root, 5 parts of lotus petiole, 6 parts of houttuynia cordata, 6 parts of garden burnet root, 5 parts of coptis chinensis, 2 parts of rhodiola rosea, 4 parts of fried hawthorn, 4 parts of raw liquorice and a proper amount of deionized water.
Preferably, the drying water content in the step a is less than or equal to 9 percent.
Preferably, the sterilization in the step c is performed under a pulsed vacuum pressure steam sterilizer, and the sterilization pressure is 210KPa and 230 KPa.
Preferably, the granulating of the homogeneous mixture in the step c means that the homogeneous mixture is prepared into granules with a particle size of 0.1-0.16 cm.
The Chinese herbal medicine preparation prepared by the preparation method for treating the live pig viral enteritis is applied to the treatment of the live pig viral enteritis.
Has the advantages that:
the invention takes weeping forsythia, dandelion, honeysuckle, magnolia officinalis, fried bitter apricot seed, gypsum, isatis root, lotus petiole, heartleaf houttuynia herb, garden burnet root, coptis, rhodiola root, fried hawthorn and raw liquorice as raw materials for preparing the Chinese herbal medicine preparation for treating viral enteritis of live pigs.
Fructus forsythiae, honeysuckle, fried bitter almond, gypsum, isatis root and houttuynia cordata are used as monarch drugs, after active ingredients of the monarch drugs are mixed, the mixed monarch drugs help to inhibit protein growth of coronavirus and rotavirus, the activity of the coronavirus and rotavirus is reduced, live pigs are helped to eliminate the coronavirus and the rotavirus through autoimmunity, viral enteritis of the pigs is effectively prevented and treated, heat clearing and detoxifying are achieved, lung diffusing and heat discharging are achieved, other symptoms caused by the coronavirus and the rotavirus are relieved, the effect of quick curative effect is achieved, loss of farmers is reduced, meanwhile rhodiola rosea, liquorice and lotus petiole are used as ministerial drugs, dandelion and coptis chinensis are used as adjuvant drugs, fried hawthorn is used as a conductant drug, the ministerial and conductant drugs are matched with monarch drug ingredients, the heat clearing and detoxifying effect is further improved, the gastrointestinal function is adjusted, appetite of the pigs is promoted.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 9 parts of fructus forsythiae, 8 parts of dandelion, 11 parts of honeysuckle, 6 parts of mangnolia officinalis, 9 parts of fried bitter almond, 5 parts of gypsum, 5 parts of isatis root, 5 parts of lotus petiole, 5.5 parts of houttuynia cordata, 7 parts of garden burnet root, 3 parts of coptis chinensis, 2.6 parts of rhodiola rosea, 3 parts of fried hawthorn, 5 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 65 deg.C to water content less than or equal to 9%, respectively pulverizing and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 10min, decocting under stirring, maintaining slightly boiling state for 30min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and packaging, wherein the granulating is to make the uniform mixture into granules with particle diameter of 0.16cm, and sterilizing under 210KPa in a pulse vacuum pressure steam sterilizer.
Example 2:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 12 parts of fructus forsythiae, 10 parts of dandelion, 10 parts of honeysuckle, 7 parts of mangnolia officinalis, 8 parts of fried bitter almond, 7 parts of gypsum, 8 parts of isatis root, 4 parts of lotus petiole, 7 parts of houttuynia cordata, 5.5 parts of garden burnet root, 4 parts of coptis chinensis, 3.6 parts of rhodiola rosea, 3.5 parts of fried hawthorn, 4.5 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 70 deg.C until the water content is less than or equal to 9%, respectively pulverizing and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 13min, decocting under stirring, maintaining slightly boiling state for 40min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and packaging, wherein the granulating is to make the uniform mixture into granules with particle diameter of 0.1cm, and sterilizing under 230KPa in a pulse vacuum pressure steam sterilizer.
Example 3:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 10 parts of fructus forsythiae, 9 parts of dandelion, 9 parts of honeysuckle, 8 parts of mangnolia officinalis, 7 parts of fried bitter almond, 6 parts of gypsum, 7 parts of radix isatidis, 5 parts of lotus petiole, 6 parts of houttuynia cordata, 6 parts of garden burnet root, 5 parts of coptis chinensis, 2 parts of rhodiola rosea, 4 parts of fried hawthorn, 4 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 85 deg.C, drying to water content less than or equal to 9%, respectively pulverizing and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 15min, decocting under stirring, keeping slightly boiling state for 50min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and packaging, wherein the granulating is to make the uniform mixture into granules with particle diameter of 0.12cm, and sterilizing under pulsed vacuum pressure steam sterilizer with sterilization pressure of 220KPa to obtain Chinese medicinal preparation.
Example 4:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 11 parts of fructus forsythiae, 9.3 parts of dandelion, 8 parts of honeysuckle, 9 parts of mangnolia officinalis, 9 parts of fried bitter almond, 7 parts of gypsum, 7 parts of isatis root, 6 parts of lotus petiole, 6.5 parts of houttuynia cordata, 6.5 parts of garden burnet root, 3.6 parts of coptis chinensis, 4 parts of rhodiola rosea, 4.5 parts of fried hawthorn, 3.5 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 75 deg.C to water content of 9% or less, pulverizing respectively, and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 17min, decocting under stirring, maintaining slightly boiling state for 60min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and packaging, wherein the granulating is to make the uniform mixture into granules with particle diameter of 0.15cm, and sterilizing under 225KPa in a pulse vacuum pressure steam sterilizer.
Example 5:
a preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis comprises the following components in parts by weight: 10 parts of fructus forsythiae, 8.5 parts of dandelion, 10 parts of honeysuckle, 6 parts of mangnolia officinalis, 8 parts of fried bitter almond, 6 parts of gypsum, 6 parts of isatis root, 4 parts of lotus petiole, 5 parts of houttuynia cordata, 5 parts of garden burnet root, 4.4 parts of coptis chinensis, 3 parts of rhodiola rosea, 5 parts of fried hawthorn, 3 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 80 deg.C to water content of 9% or less, pulverizing respectively, and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 20min, decocting under stirring, maintaining slightly boiling state for 52min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and packaging, wherein the granulating is to make the uniform mixture into granules with particle diameter of 0.13cm, and sterilizing under 230KPa in a pulse vacuum pressure steam sterilizer.
The clinical application is as follows: test of drug efficacy
Clinical pharmacodynamic tests of the invention are carried out in a certain pig farm from the beginning of 2 months in 2019 to the end of 4 months in 2019, and the effective rate of the invention for curing piglets with acute viral gastroenteritis and other symptoms in the whole experiment period reaches more than 70%.
180 piglets with the symptoms of the acute viral gastroenteritis of the piglets are selected and randomly divided into 6 groups, namely 1 group for conventional treatment and 5 groups for the experiment of the invention, and each group in each embodiment has basically consistent feeding and management water average. The invention is added into the conventional feed of the pigs of the experimental group according to the proportion of 2 percent. In the conventional treatment group, the medicament is molinidine hydrochloride tablets, and the dosage is carried out according to the use instruction. The results are as follows:
it is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (7)
1. A preparation method of a Chinese herbal medicine preparation for treating live pig viral enteritis is characterized by comprising the following components in parts by weight: 9-12 parts of fructus forsythiae, 8-10 parts of dandelion, 8-11 parts of honeysuckle, 6-9 parts of mangnolia officinalis, 7-9 parts of fried bitter almond, 5-7 parts of gypsum, 6-8 parts of isatis root, 4-6 parts of lotus petiole, 5-7 parts of houttuynia cordata, 5-7 parts of sanguisorba officinalis, 3-5 parts of coptis chinensis, 2-4 parts of rhodiola rosea, 3-5 parts of fried hawthorn, 3-5 parts of raw liquorice and a proper amount of deionized water;
the preparation method comprises the following steps:
a. oven drying fructus forsythiae, herba Taraxaci, flos Lonicerae, parched semen Armeniacae amarum, Gypsum Fibrosum, radix Isatidis, petiolus Nelumbinis, Coptidis rhizoma, parched fructus crataegi and Glycyrrhrizae radix at 65-85 deg.C, respectively pulverizing, and sieving to obtain fine powder;
b. mixing herba Houttuyniae, radix Rhodiolae, cortex Magnolia officinalis and radix Sangusorbae, soaking in 10 times of deionized water for 10-20min, decocting under stirring, maintaining slightly boiling state for 30-60min, and concentrating the obtained decoction to obtain paste;
c. mixing the fine powder obtained in the step a and the paste obtained in the step b, adding a proper amount of deionized water, and uniformly stirring to obtain a uniform mixture; granulating the obtained uniform mixture, oven drying, sterilizing, and bagging to obtain Chinese medicinal preparation.
2. The preparation method of the Chinese herbal medicine preparation for treating porcine viral enteritis according to claim 1, which is characterized by comprising the following components in parts by weight: 10-11 parts of fructus forsythiae, 9-10 parts of dandelion, 9-11 parts of honeysuckle, 6-8 parts of mangnolia officinalis, 7-8 parts of fried bitter almond, 6-7 parts of gypsum, 6-7 parts of isatis root, 5-6 parts of lotus petiole, 5-6 parts of houttuynia cordata, 6-7 parts of sanguisorba officinalis, 4-5 parts of coptis chinensis, 2-3 parts of rhodiola rosea, 3-4 parts of fried hawthorn, 3-4 parts of raw liquorice and a proper amount of deionized water.
3. The preparation method of the Chinese herbal medicine preparation for treating porcine viral enteritis according to claim 1, which is characterized by comprising the following components in parts by weight: 10 parts of fructus forsythiae, 9 parts of dandelion, 9 parts of honeysuckle, 8 parts of mangnolia officinalis, 7 parts of fried bitter almond, 6 parts of gypsum, 7 parts of isatis root, 5 parts of lotus petiole, 6 parts of houttuynia cordata, 6 parts of garden burnet root, 5 parts of coptis chinensis, 2 parts of rhodiola rosea, 4 parts of fried hawthorn, 4 parts of raw liquorice and a proper amount of deionized water.
4. The preparation method of the Chinese herbal medicine preparation for treating porcine viral enteritis according to claim 1, which is characterized by comprising the following steps: the drying water content in the step a is less than or equal to 9 percent.
5. The preparation method of the Chinese herbal medicine preparation for treating porcine viral enteritis according to claim 1, which is characterized by comprising the following steps: the sterilization in the step c is carried out under a pulse vacuum pressure steam sterilizer, and the sterilization pressure is 210KPa and 230 KPa.
6. The preparation method of the Chinese herbal medicine preparation for treating porcine viral enteritis according to claim 1, which is characterized by comprising the following steps: the step c of granulating the homogeneous mixture means that the homogeneous mixture is granulated to have a particle size of 0.1-0.16 cm.
7. The use of a herbal preparation prepared by the method of any one of claims 1-6 for the treatment of porcine viral enteritis.
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| CN105982995A (en) * | 2016-01-28 | 2016-10-05 | 宿州瑞泰农业发展有限公司 | Specific traditional Chinese veterinary oral medicine for treating chronic hog cholera |
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Application publication date: 20200107 |