CN106265936A - 一种降压保健冲剂及其制备方法 - Google Patents
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Abstract
本发明涉及一种降压保健冲剂及其制备方法，冲剂颗粒由以下重量份组分制得：葛根15‑18份、三七10‑15份、川芎15‑18份、桑白皮15‑18份、牛樟芝5‑8份、灵芝5‑8份、虫草5‑8份、黑木耳发酵液30‑40份、香菇发酵液30‑40份、白灵菇发酵液30‑40份。制备方法包括中药液的提取和菌丝体的破壁处理及制粒过程。本发明降压效果好，服用方便，且能提高身体免疫力，毒副作用小。
Description
技术领域
本发明涉及保健品技术领域，具体涉及一种降压保健冲剂及其制备方法。
背景技术
近20年来高血压的发病率在我国几乎增加了一倍，由高血压引发的心脑血管疾病的死亡率已排到所有疾病死亡率的第一位。高血压病严重地危害人们的健康和生命，它不仅是一个独立的疾病，同时又作为心脑血管疾病的重要危险因素，导致心、脑、肾、血管、眼底的结构和功能的改变和损害，引起相关疾病的发生。目前，常用的降压药物，多为西药，长期服用容易产生副作用，虽然血压降下来了，但是身体的其他功能受到影响。
发明内容
为解决上述问题，本发明提供一种降压效果好，服用方便，且能提高身体免疫力，毒副作用小的降压保健冲剂。
本发明的技术方案
一种降压保健冲剂，冲剂颗粒由以下重量份组分制得：葛根15-18份、三七10-15份、川芎15-18份、桑白皮15-18份、牛樟芝5-8份、灵芝5-8份、虫草5-8份、黑木耳发酵液30-40份、香菇发酵液30-40份、白灵菇发酵液30-40份。
进一步地，冲剂颗粒由以下重量份组分制得：罗布麻15-18份、天麻15-18份、刺五加15-18份、杜仲15-18份。
优选的，冲剂颗粒由以下重量份组分制得：葛根16份、三七13份、川芎16份、桑白皮16份、牛樟芝7份、灵芝7份、虫草7份、黑木耳发酵液35份、香菇发酵液35份、白灵菇发酵液35份。
进一步优选的，冲剂颗粒由以下重量份组分制得：葛根16份、三七13份、川芎16份、桑白皮16份、牛樟芝7份、灵芝7份、虫草7份、黑木耳发酵液35份、香菇发酵液35份、白灵菇发酵液35份、罗布麻16份、天麻16份、刺五加16份、杜仲16份。
一种降压保健冲剂的制备方法，包括以下步骤：
（1）分别将黑木耳发酵液、香菇发酵液、白灵菇发酵液经2500-3000转/分钟离心处理10-15分钟，过滤分别得黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，合并上述所有滤液保存待用；
（2）分别将步骤（1）过滤得到的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体进行破壁处理；
（3）将葛根、三七、川芎、桑白皮、罗布麻、牛樟芝、灵芝、虫草、天麻、刺五加、杜仲按照上述重量份称取，混匀，加入混合物总质量8-10倍的水，煮沸提取30-60min，过滤提取液，得滤液；
（4）步骤（3）的滤渣再加入步骤（3）混合物总质量3-5倍的水，煮沸提取30-60min，过滤提取液，得滤液；
（5）合并步骤（1）、步骤（3）和步骤（4）的滤液，晾凉后加入所述破壁后的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，混匀即可；
（6）将步骤（5）所得液体，常压浓缩至稠膏状，比重为1.01-1.10；稠膏在干燥箱中进行干燥，温度：75-78℃，并进行翻动，干燥时间12-48小时；粉碎；制粒。
上述各发酵液的获得方式均为本领域的常规技术，本领域技术人员无需经过创造性劳动即可获得，且实验证明获得各发酵液所使用的培养基对本发明的效果无明显影响，也可选择将菌丝体从发酵液中分离出来，再分散到与发酵液等量的水中来代替菌丝体发酵液，实验证明二者效果相当。步骤（2）中所述细胞组织破壁处理采用超声波破碎法，也是本领域的常规技术。各发酵液所使用的培养基为：质量含量为2%的葡萄糖，质量含量为9%豆渣，质量含量为0.05%的硫酸镁，质量含量为0.1%的磷酸二氢钾，余量为饮用水。发酵时间为6天，发酵温度为25℃。
葛根：有解肌退热，透疹，生津止渴，升阳止泻的功效。
三七：具有显著的活血化瘀、消肿定痛功效。
川芎：行气开郁，祛风燥湿，活血止痛，治头痛旋晕、肋痛腹疼、经闭、难产、痈疽疮疡等症
桑白皮：有降血糖，利尿，抗人体艾滋病病毒HIV，抗菌等作用。
牛樟芝：主要为Lanostane类之衍生物及某些三萜类化合物，可以抑制（ACE）而达到降血压的目的。
灵芝：对于增强人体免疫力，调节血糖，控制血压，辅助肿瘤放化疗，保肝护肝，促进睡眠等方面均具有显著疗效.具有强身健体之效。
虫草：用于肾虚阳痿，遗精，头昏耳鸣；肺虚或肺肾两虚，喘咳短气，或咳血；体虚自汗，畏风。
罗布麻：具有有清火，降压，强心，利尿的功效。能够治疗心脏病等。
天麻：功能主治息风，定惊。治眩晕眼黑，头风头痛，肢体麻木，半身不遂，语言蹇涩，小儿惊痫动风。
刺五加：祛风湿，补肝肾，强筋骨。用于风湿痹痛，筋骨痿软，小儿行迟，体虚乏力，水肿，脚气。
杜仲：其味甘，性温。有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。
本发明的用法用量：
一日服用两次，早晚各一次，每次各1-2g，用温水冲泡。
本发明的有益效果：
本发明配方中各组分均具有降压效果，复配后相互之间还可相互作用，产生协同增效作用，进一步提高降压效果。本发明的中药普遍具有健肾增强机体免疫力的功效，上述组分共同作用，可有效提高牛樟芝的降压效果。
破壁后的黑木耳菌丝体能够促进胃肠蠕动而防止便秘，有利于体内大便中的有毒有害物质及时清除和排出，从而起到预防直肠癌等癌症的作用，还可促使肠道脂肪食物的***，减少食物中脂肪的吸收，从而起到防止肥胖和减肥作用。癌症病人在使用这种破壁后的黑木耳菌丝体后，体内球蛋白的组成成分有显著增加，从而增强了抗体。
破壁后的香菇菌丝体有健脾胃、益气血、益智安神、美容颜之功效。还可化痰理气，益胃和中，解毒等作用。
破壁后的白灵菇菌丝体有消积、杀虫、镇咳、消炎和防治妇科***肿瘤等功效。它含有真菌多糖和维生素等生理活性物质及多种矿物质，具有调节人体生理平衡，增强人体免疫功能的作用。
此外，本发明使用菌丝体，较子实体成本显著降低，且菌丝体是发酵液过滤得到的菌丝体，发酵液也添加到冲剂中，不浪费原材料中的有益成分，破壁后的菌丝体相比于未破壁的菌丝体更容易让人体吸收。在无菌环境中培养，无农药残留，不受空气污染，保证饮料的饮用安全。
本发明的制备方法简单，且能发挥各成分的最大药效，利于吸收，不浪费原材料，冲剂方便饮用。
具体实施方式
表1具体实施例
表2对比实施例
降压动物实验病例
自发性高压大鼠70只，雌雄数量相等，体重220±9g,饲养条件：室温25±2℃，人工照明12h/d(h/d),按性别分笼饲养，每笼5只，自由饮水，喂以21%高蛋白饲料。随机平均分组，分为空白对照组，实施例1组、实施例5组、实施例6组、对比例1组、对比例2组、对比例3组，每组10只，1克冲剂用10毫升温水冲泡，每天早晚各灌药2毫升，空白组灌相同剂量的饮用水。
实施例1组采用实施例1冲剂，实施例5组采用实施例5冲剂，实施例6组采用实施例6冲剂，对比例1组采用对比例1冲剂，对比例2组采用对比例2冲剂，对比例3组采用对比例3冲剂，空白对照组灌相同剂量的饮用水。
实施例1组、实施例5组、实施例6组、对比例1组、对比例2组、对比例3组按照以下方法制备：
（1）分别将黑木耳发酵液、香菇发酵液、白灵菇发酵液经3000转/分钟离心处理15分钟，过滤分别得黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，合并上述所有滤液保存待用；
（2）分别将步骤（1）过滤得到的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体进行破壁处理；
（3）将葛根、三七、川芎、桑白皮、罗布麻、牛樟芝、灵芝、虫草、天麻、刺五加、杜仲按照上述重量份称取，混匀，加入混合物总质量8倍的水，煮沸提取45min，过滤提取液，得滤液；
（4）步骤（3）的滤渣再加入步骤（3）混合物总质量5倍的水，煮沸提取45min，过滤提取液，得滤液；
（5）合并步骤（1）、步骤（3）和步骤（4）的滤液，晾凉后加入所述破壁后的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，混匀即可；
（6）将步骤（5）所得液体，常压浓缩至稠膏状，比重为1.01-1.10；稠膏在干燥箱中进行干燥，温度：75-78℃，并进行翻动，干燥时间12-48小时；粉碎；制粒。
表3各组自发性高压大鼠连续灌上述实施例和对比例15天后的降压效果比较
收缩压下降大于1.33 kPa者为有效。
上述实验表明实施例1、实施例5、实施例6、对比例1、对比例2、对比例3的冲剂能够明显降压效果，且实施例6的降压效果最好，牛樟芝、虫草、香菇发酵液三者在降压方面具体协同作用，能够显著降低血压。
典型案例
1黄某，男，51岁，血压偏高，服用本发明半年后，血压恢复正常。
2时某，女，44岁，血压偏高，抵抗力差，常感觉疲惫，服用本发明3个月后，感觉身体明显好转，气色变好。
3姜某，男，60，特别容易感到疲劳，常感头晕眼花，服用本发明1个月后，上述症状明显变好，继续服用本发明半年后上述症状基本消失。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其他实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (5)
1.一种降压保健冲剂，其特征在于，冲剂颗粒由以下重量份组分制得：葛根15-18份、三七10-15份、川芎15-18份、桑白皮15-18份、牛樟芝5-8份、灵芝5-8份、虫草5-8份、黑木耳发酵液30-40份、香菇发酵液30-40份、白灵菇发酵液30-40份。
2.根据权利要求1所述的一种降压保健冲剂，其特征在于，冲剂颗粒还由以下重量份组分制得：罗布麻15-18份、天麻15-18份、刺五加15-18份、杜仲15-18份。
3.根据利要求1所述的一种降压保健冲剂，其特征在于，冲剂颗粒由以下重量份组分制得：葛根16份、三七13份、川芎16份、桑白皮16份、牛樟芝7份、灵芝7份、虫草7份、黑木耳发酵液35份、香菇发酵液35份、白灵菇发酵液35份。
4.根据权利要求2所述的一种降压保健冲剂，其特征在于，冲剂颗粒由以下重量份组分制得：葛根16份、三七13份、川芎16份、桑白皮16份、牛樟芝7份、灵芝7份、虫草7份、黑木耳发酵液35份、香菇发酵液35份、白灵菇发酵液35份、罗布麻16份、天麻16份、刺五加16份、杜仲16份。
5.权利要求2或4所述的一种降压保健冲剂的制备方法，其特征在于，包括以下步骤：（1）分别将黑木耳发酵液、香菇发酵液、白灵菇发酵液经2500-3000转/分钟离心处理10-15分钟，过滤分别得黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，合并上述所有滤液保存待用；
（2）分别将步骤（1）过滤得到的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体进行破壁处理；
（3）将葛根、三七、川芎、桑白皮、罗布麻、牛樟芝、灵芝、虫草、天麻、刺五加、杜仲按照上述重量份称取，混匀，加入混合物总质量8-10倍的水，煮沸提取30-60min，过滤提取液，得滤液；
（4）步骤（3）的滤渣再加入步骤（3）混合物总质量3-5倍的水，煮沸提取30-60min，过滤提取液，得滤液；
（5）合并步骤（1）、步骤（3）和步骤（4）的滤液，晾凉后加入所述破壁后的黑木耳菌丝体、香菇菌丝体、白灵菇菌丝体，混匀即可；
（6）将步骤（5）所得液体，常压浓缩至稠膏状，比重为1.01-1.10；稠膏在干燥箱中进行干燥，温度：75-78℃，并进行翻动，干燥时间12-48小时；粉碎；制粒。
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