CN106177351A - A kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof - Google Patents

A kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof Download PDF

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CN106177351A
CN106177351A CN201610540650.4A CN201610540650A CN106177351A CN 106177351 A CN106177351 A CN 106177351A CN 201610540650 A CN201610540650 A CN 201610540650A CN 106177351 A CN106177351 A CN 106177351A
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parts
radix
chinese medicine
rhizoma rhei
preparation
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赵中学
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Gansu Xin Sheng Source Biological Technology Development LLC
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Abstract

The present invention relates to a kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.It is main prescription with Lixian, Ganshu Radix Et Rhizoma Rhei, includes following component by weight: Radix Et Rhizoma Rhei 50～70 parts, Radix Scutellariae 20～35 parts, Radix Sophorae Flavescentis 10～15 parts, Rhizoma Paridis 10～15 parts, Borneolum Syntheticum 1～3 parts, the Radix Rehmanniae 5～15 parts, Flos Lonicerae 15～25 parts, Borax 0.05～0.1 part；After the Chinese medicine extract that above-mentioned Chinese medicine composition prepares, then prepare tablet with diluent, correctives, binding agent, lubricant.The buccal tablets mainly containing Radix Et Rhizoma Rhei that the present invention provides, it may be used for treating oral diseases, mainly treats periodontitis, gingivitis, gingival hemorrhage, oral ulcer etc., has taking convenience, an advantage that therapeutic effect is good.

Description

A kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof
Technical field
The present invention relates to a kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof, be main group with Lixian, Ganshu Radix Et Rhizoma Rhei (Radix Et Rhizoma Rhei) Side, belongs to technical field of traditional Chinese medicine preparation.
Background technology
Oral disease all night can produce certain impact to the quality of life of people, includes: periodontal, ulcer, goes out Blood etc..Periodontal disease refers to damage gingiva and the inflammation of tooth supporting tissue or infectious disease.It is by often adhering to neck Bacterial in dental plaque in portion and gingival sulcus.The toxin long term of bacterial plaque microorganism and generation thereof, in gingiva, causes Immune response reacts.The inflammatory reaction of gingiva in early days, i.e. gingivitis.When inflammation is diffused into deep periodontal tissue, cause The changes such as frontal resorption and periodontal membrane dissolve, destruction, this is periodontitis.Gingivitis is the starting stage of periodontitis, but The most all of gingivitis all can develop into periodontitis, and this is accomplished by treating in early days.It addition, oral ulcer to be oral cavity the most normal One of disease occurred, causes the reason that oral ulcer occurs more, is most commonly that recurrent oral ulceration (also referred to as recurrent Aphtha), secondly cause for various wounds (such as inappropriate artificial tooth, the stimulation etc. of the residual root sharpened edge of tooth) is traumatic Oral ulcer, also has some special infection (such as tuberculosis, syphilis etc.) and oral mucosa canceration to also result in the generation of oral ulcer.
The Therapeutic Method of periodontal includes: 1, buys and controls: control bacterial plaque, removes local excitation thing, removes with buying erasion Tartar.；(2) medicine: periodontal pocket and root face drug treating, after striking off subgingival calculus, dips in the pathologic granulation probe of inwall Corrosive medicine (such as iodine phenol) enters periodontal pocket and reaches therapeutic effect；(3) operation: periodontal pocket is removed in operation, the not deep person of periodontal pocket Can be excised by periodontal pocket, deep periodontal pocket can use inwall curettage, excision newly to adhere to art, turn over and distinguish art etc.；(4) fixing pine tooth, shape Become periodontal splint, note controlling bacterium evil spirit, pull out the cacodontia that can not retain.
CN103638279A discloses a kind of Chinese medicine treating periodontal disease, the Chinese medicine being made up of the medical material of following weight proportion Preparation: Rhizoma Anemarrhenae 10-15 part, Flos Eriocauli 12-15 part, Periostracum Cicadae 10-15 part, Radix Et Rhizoma Rhei 8-10 part, drynaria baronii 20-25 part, Herba Verbenae 15-20 Part, Herba Schisandrae intermediae 20-25 part, Rhizoma Drynariae 20-25 part, Fructus Mori do 10-12 part, Os Sepiae 15-20 part.CN103830565A discloses A kind of Chinese medicine for treating periodontal disease, it is characterised in that be prepared from by the medical material of following weight proportion: Rhizoma Polygonati Odorati 12～15 Part, Fructus Corni 5～6 parts, Fructus Psoraleae 8～10 parts, Radix Flemingiae Philippinensis 8～10 parts, Concha Ostreae 20～25 parts, Fructus Luffae 25～30 parts, the Radix Rehmanniae 8 ～10 parts, Radix Angelicae Sinensis 4～5 parts, Cortex Moutan 8～10 parts, Rhizoma Cimicifugae 4～5 parts, Radix Glycyrrhizae 4～5 parts, Radix Zanthoxyli Planispini 0～6 parts, Fructus Arctii 0 ～8 parts.Preparation method is: weighs above-mentioned medical material and inserts in container, adds 8 times amount water, decocts 1.5 hours, filters；Filtering residue adds 6 times amount water, Decoct 1 hour, filter；Merging filtrate, concentrates, and is dried, and loads capsule shells.CN102579793A disclose one treat oral cavity burst The Chinese medicine composition of infections, the weight portion of its constitutive material is: Radix Astragali 28-32g, pale blue black pigment used by women in ancient times to paint their eyebrows 8-12g, Herba Taraxaci 28-32g, wheat Winter 28-32g, Radix Glehniae 28-32g, Radix Scrophulariae 28-32g, Rhizoma dioscoreae 28-32g, Radix Rehmanniae 18-22g, Rhizoma Atractylodis Macrocephalae 28-32g, Herba Artemisiae Scopariae 18- 22g, Radix Scutellariae 28-32g, Fructus Aurantii 23-28g, Radix Glycyrrhizae 13-18g, Rhizoma Coptidis 28-32g, Radix Platycodonis 18-22g, grind to the powder altogether, rush with boiled water Clothes.
Summary of the invention
It is an object of the invention to: providing a kind of main with the Chinese medicine composition that Lixian, Ganshu Radix Et Rhizoma Rhei is main prescription, it is permissible For treating oral diseases, mainly treat periodontitis, gingivitis, gingival hemorrhage, oral ulcer etc..
Technical scheme is:
First aspect:
A kind of Chinese medicine composition mainly containing Radix Et Rhizoma Rhei, includes following component by weight: Radix Et Rhizoma Rhei 50～70 parts, Radix Scutellariae 20～35 parts, Radix Sophorae Flavescentis 10～15 parts, Rhizoma Paridis 10～15 parts, Borneolum Syntheticum 1～3 parts, the Radix Rehmanniae 5～15 parts, Flos Lonicerae 15～25 parts, Borax 0.05～0.1 part.
Described Chinese medicine composition, composition weight is Radix Et Rhizoma Rhei 60 parts, Radix Scutellariae 25 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Paridis 12 parts, Borneolum Syntheticum 20 Part, 10 parts of the Radix Rehmanniae, Flos Lonicerae 20 parts, Borax 0.05 part.
Second aspect:
The Chinese medicine extract prepared by described Chinese medicine composition.
The third aspect:
The preparation method of described Chinese medicine extract, comprise the steps: by Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, Boiling 2 times after Flos Lonicerae mixing, the weight that every time adds water is 6 times of Chinese medicine composition gross weight, decocting time 1 hour, will Twice decocting liquid merges that to filter after medicinal residues concentrating under reduced pressure again be thick paste, obtains Chinese medicine extract.
Fourth aspect:
Include the medicament of above-mentioned Chinese medicine extract.
Described medicament, refers to buccal tablet.
5th aspect:
The preparation method of described medicament, comprises the steps: by weight, by Chinese medicine extract 40～50 parts and diluent 20～30 parts of mix homogeneously, obtain particulate matter after drying；By correctives 70～80 parts, after binding agent 5～10 parts of mixing, add To particulate matter, adding lubricant 4～8 parts, mix homogeneously, after direct compression and get final product.
Described correctives is selected from citric acid, acesulfame potassium, menthol, stevioside, glycyrrhizin, aspartame, trichlorine sugarcane One or more in sugar, cyclamate, Talin, saccharin.
Described diluent selected from diluent selected from lactose, Icing Sugar, mannitol, carboxymethyl starch sodium, dextrin, maltose or The mixture of one or more in person's soybean polysaccharide；It is even more preferred that lactose, dextrin, soybean polysaccharide are according to weight ratio 2:3:1 Mixture.It is still preferred that, soybean polysaccharide refers to use cross-linking modified soybean polysaccharide.
Described binding agent is from PVP K30 ethanol solution, hydroxypropyl methylcellulose, gelatin, simple syrup, ethanol or card ripple One or more in nurse.
Described lubricant is selected from magnesium stearate, silicon dioxide and Pulvis Talci one or more.
6th aspect:
Chinese medicine composition is used for treating the application in periodontitis, gingivitis, gingival hemorrhage or stomatocace medicine in preparation.
Radix Et Rhizoma Rhei, bitter, cold.Return spleen, stomach, large intestine, liver, pericardium channel, its heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, modern doctor Learning the effect finding to use Radix Et Rhizoma Rhei to may also operate as antiinflammatory, tested on the body of animal, effect is the prettyst good.Radix Et Rhizoma Rhei In rheum emodin mainly by changing ion concentration and transhipment, antioxidation and free radical, the secretion affecting inflammatory factor and enzyme The approach such as activity, apoptosis realize antiinflammatory, antineoplastic action；Chrysophanic acid in Radix Et Rhizoma Rhei be a kind of be present in Radix Et Rhizoma Rhei fear The monomer of quinone derivative, its pharmacological use is quite varied, and it has antitumor, antibacterial, blood sugar lowering, tune fat, eliminating inflammation and expelling toxin；Chrysophanol There is antibacterial activity, human body is had relieving asthma, function of gallbladder promoting, protect the liver, antihypertensive effect, and have the most antibacterial, antiinflammation;Blood can be shortened Setting time, excitor nerve, paralysis muscle, and there is cough-relieving, diuresis and antitumaous effect.For making medicine.
Radix Scutellariae, Radix Sophorae Flavescentis are heat and toxic materials clearing away medicine, and cold in nature, bitter in the mouth has the function of heat clearing and damp drying, eliminating fire and detoxication, dispersing swelling and dissipating binds； Rhizoma Paridis hardship is slightly cold, and returns Liver Channel, function heat-clearing and toxic substances removing, reducing swelling and alleviating pain；It is all ministerial drug；
Borneolum Syntheticum has logical all keys, dissipates stagnated fire, removing the necrotic tissue and promoting granulation, effect of cooling blood and relieving pain, topical application energy pain relieving rapidly, can promote again Ulcer surface heals；Radix Rehmanniae sweet in the mouth, hardship, cold in nature, GUIXIN, liver, lung meridian, nourishing YIN and supplementing blood, with Radix Scutellariae, Radix Sophorae Flavescentis jointly, can be raw with YIN nourishing The effect in Tianjin, is all adjuvant drug；
Flos Lonicerae, resolving heat and reducing pathogenic fire, coordinating the actions of various ingredients in a prescription.Full presciption medicine is gentle, based on YIN nourishing and the production of body fluid promoting, is main having concurrently for hyperactivity of fire caused by deficiency of YIN Damp, the feature of pathogenic heat.
Borax, sweet, salty, cool.Attach to the lung and stomach meridians.Application: 1. laryngopharynx swelling and pain, aphtha of the mouth and tongue, cataract.This product energy heat clearing away Removing toxic substances, anticorrosion of subsiding a swelling, for larynx section and ophthalmology common medicine and more external.If the same use of compatibility Borneolum Syntheticum, Matrii Sulfas Exsiccatus, Cinnabaris, pharynx can be controlled Larynx, ability to speak swell and ache, such as BINGPENG SAN (" Waike Zhengzong, Orthodox Manual of External Diseases ")..
Beneficial effect
The buccal tablets mainly containing Radix Et Rhizoma Rhei that the present invention provides, it may be used for treating oral diseases, mainly treats Periodontitis, gingivitis, gingival hemorrhage, oral ulcer etc., there is taking convenience, advantage that therapeutic effect is good.
Detailed description of the invention
The present invention is main prescription with Lixian, Ganshu Radix Et Rhizoma Rhei, through the compatibility with other each taste Chinese medicine, has prepared application In treatment treatment periodontitis, gingivitis, gingival hemorrhage, the tablet of oral ulcer.
Embodiment 1
Mainly contain the Chinese medicine composition of Radix Et Rhizoma Rhei, include following component by weight: be Radix Et Rhizoma Rhei 50 parts, Radix Scutellariae 20 parts, bitter Join 10 parts, Rhizoma Paridis 10 parts, Borneolum Syntheticum 1 part, 5 parts of the Radix Rehmanniae, Flos Lonicerae 15 parts, Borax 0.05 part.
The preparation method of Chinese medicine extract, comprises the steps: Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, gold Boiling 2 times after Flos Lonicerae mixing, the weight that every time adds water is 6 times of Chinese medicine composition gross weight, and decocting time 1 hour, by two Secondary decocting liquid merge filter medicinal residues after again concentrating under reduced pressure be thick paste, then through spray drying after, obtain Chinese medicine extract.
The preparation method of tablet, comprises the steps: by weight, is mixed with diluent 20 parts by Chinese medicine extract 40 parts Close uniformly, obtain particulate matter after drying；By correctives (acesulfame potassium) 70 parts, binding agent, (lactose, dextrin, soybean polysaccharide are according to weight The amount mixture than 2:3:1) after 5 parts of mixing, add to particulate matter, add lubricant (magnesium stearate) 4 parts, mixing is all Even, after direct compression and get final product.
Embodiment 2
Mainly contain the Chinese medicine composition of Radix Et Rhizoma Rhei, include following component by weight: be Radix Et Rhizoma Rhei 70 parts, Radix Scutellariae 35 parts, bitter Join 15 parts, Rhizoma Paridis 15 parts, Borneolum Syntheticum 3 parts, 15 parts of the Radix Rehmanniae, Flos Lonicerae 25 parts, Borax 0.1 part.
The preparation method of Chinese medicine extract, comprises the steps: Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, gold Boiling 2 times after Flos Lonicerae mixing, the weight that every time adds water is 6 times of Chinese medicine composition gross weight, and decocting time 1 hour, by two Secondary decocting liquid merge filter medicinal residues after again concentrating under reduced pressure be thick paste, then through spray drying after, obtain Chinese medicine extract.
The preparation method of tablet, comprises the steps: by weight, is mixed with diluent 30 parts by Chinese medicine extract 50 parts Close uniformly, obtain particulate matter after drying；By correctives (acesulfame potassium) 80 parts, binding agent, (lactose, dextrin, soybean polysaccharide are according to weight The amount mixture than 2:3:1) after 10 parts of mixing, add to particulate matter, add lubricant (magnesium stearate) 8 parts, mixing is all Even, after direct compression and get final product.
Embodiment 3
Described Chinese medicine composition, composition weight is Radix Et Rhizoma Rhei 60 parts, Radix Scutellariae 25 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Paridis 12 parts, Borneolum Syntheticum 2 parts, life 10 parts of ground, Flos Lonicerae 20 parts, Borax 0.05 part, Borax 0.05 part.
The preparation method of Chinese medicine extract, comprises the steps: Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, gold Boiling 2 times after Flos Lonicerae mixing, the weight that every time adds water is 6 times of Chinese medicine composition gross weight, and decocting time 1 hour, by two Secondary decocting liquid merge filter medicinal residues after again concentrating under reduced pressure be thick paste, then through spray drying after, obtain Chinese medicine extract.
The preparation method of tablet, comprises the steps: by weight, is mixed with diluent 25 parts by Chinese medicine extract 45 parts Close uniformly, obtain particulate matter after drying；By correctives (acesulfame potassium) 75 parts, binding agent, (lactose, dextrin, soybean polysaccharide are according to weight The amount mixture than 2:3:1) after 8 parts of mixing, add to particulate matter, add lubricant (magnesium stearate) 5 parts, mixing is all Even, after direct compression and get final product.
Embodiment 4
Difference with embodiment 3 is: described soybean polysaccharide refers to through cross-linking modified.Method of modifying is: by weight Meter, is dissolved in soybean polysaccharide 15 parts in 350 parts of water, adds 4 parts of sodium hexameta phosphate, and use the hydrochloric acid solution of 1wt% to regulate PH to 4～5, more centrifugal 25min under the rotating speed of 7000rpm, take supernatant, and the ethanol adding 95vol.% precipitates, then warp Cross centrifugal 15min under the rotating speed of 5000rpm, take precipitation, after water being precipitated and dissolved in, obtain modified soybean after carrying out lyophilizing many Sugar.
Described Chinese medicine composition, composition weight is Radix Et Rhizoma Rhei 60 parts, Radix Scutellariae 25 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Paridis 12 parts, Borneolum Syntheticum 2 Part, 10 parts of the Radix Rehmanniae, Flos Lonicerae 20 parts, Borax 0.05 part.
The preparation method of Chinese medicine extract, comprises the steps: Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, gold Boiling 2 times after Flos Lonicerae mixing, the weight that every time adds water is 6 times of Chinese medicine composition gross weight, and decocting time 1 hour, by two Secondary decocting liquid merge filter medicinal residues after again concentrating under reduced pressure be thick paste, then through spray drying after, obtain Chinese medicine extract.
The preparation method of tablet, comprises the steps: by weight, is mixed with diluent 25 parts by Chinese medicine extract 45 parts Close uniformly, obtain particulate matter after drying；By correctives (acesulfame potassium) 75 parts, binding agent, (lactose, dextrin, modified soybean polysaccharide are pressed Mixture according to weight ratio 2:3:1) after 8 parts of mixing, add to particulate matter, add lubricant (magnesium stearate) 5 parts, mixing Uniformly, after direct compression and get final product.
Chinese medicine composition is applied to the treatment of periodontitis
1, experimental technique
By healthy male 200～4 months old rats 40 of 250g weight, be divided into 4 groups and often organize 10, be randomly divided into model control group and The treatment group (basic, normal, high dosage) of Chinese medicine extract treatment.
With the chloral hydrate 0.3ml/100g intraperitoneal injection of anesthesia of 10%, rat dorsal position is fixed, and fully exposes the visual field, tooth Week calibrated probe Periodontal Probing Depth record (0.5mm) in case reference when measuring periodontal health, on oral examination probe separates Jaw first molar cheek jaw side gingiva about 1mm, the ligature of 0.2mm enters through the far middle adjacent gap of first molar, encloses around neck portion one, Screw in Jin, the broken ends of fractured bone be positioned at incisor and grind one's teeth in sleep between diastema width at, ligature is placed in gingival sulcus as far as possible, with method ligature offside Maxillary first molar.Ligation played the high sucrose solution of 10% same day and substitutes drinking-water, within every 7 days, surveyed Periodontal Probing Depth until the 4th week, When Periodontal Probing Depth and periodontal health, Periodontal probing compares, more than 1mm, difference estimates that Periodontitis Model is set up.
After ligaturing 4 weeks, rat red swelling of gingiva seen from perusal, visit and examine the most hemorrhage and can visit and periodontal pocket.Often organize immediately Selecting a rat vertebra dislocation method to put to death, take bilateral upper jaw bone, the paraformaldehyde of 4% fixes 48 hours, repairs specimen, only retains Grinding one's teeth in sleep section jawbone and periodontal tissue, cheek-tongue direction is taken the photograph X sheet, has been seen whether frontal resorption.Remove soft tissue, haematoxylin labelling 15 seconds to remove display enamelo-cemental junction.Collect specimen digital photograph, periodontal calibrated probe measurement markers the most, measure the upper jaw the One 6, cheek jaw side anchor point enamelo-cemental junction of grinding one's teeth in sleep, to the distance on corresponding alveolus top, takes average, specifies inflammatory model success. Model control group is normally raised, treatment group gavage every day once corresponding Chinese medicine extract 20,40, basic, normal, high dose of 80mg/kg( Amount).
2, detection method
Withdraw from ligation before medication first, measure each group of clinical indices as baseline criteria, measured every 5 days during medication and once face Bed index (0,5,10,15 days), until experiment terminates (treating 15 days).
BOP standard: the chloral hydrate intraperitoneal injection of anesthesia of 10%, fixing, periodontal probe is visited at the bottom of bag or at the bottom of gingival sulcus, removes Observe after probe and within 30 seconds, see with or without hemorrhage, in HE dyeing Microscopic observation gingiva situation.
Use immunohistochemistrySP SP is used to record IL-6 gray value.
Test and record every average data such as table 1 below:
Table 1:
As can be seen from the table, after treatment, rat is bright compared with on model group Symptoms for the Chinese medicine extract that the present invention provides Showing and alleviate, and the IL-6 gray value for the treatment of group is all significantly lower than model control group, therefore this Chinese medicine composition can realize controlling Treat the purpose of periodontitis.
Impact on Cavia porcellus gingivitis model
1. experiment material
1.1 medicines and reagent
Clinical periodontal pocket anaerobe isolated culture method: obtain bacterial plaque with syringe from clinical patients with periodontitis periodontal pocket is logical Cross Anaerobic culturel, obtain dental plaque total anaerobic culture liquid.
2. method and result
(statistical method: measurement data represents with X ± S, the neat person of variance is with variance analysis and independent samples t-test analysis；Heterogeneity of variance Person is with rank test analysis.Enumeration data is with X2 check analysis.Ranked data are with Ridit check analysis.)
2.1. the impact on Cavia porcellus gingivitis model
2.1.1 method
Modeling: fasten knot Cavia porcellus mandibular incisors neck portion with correction steel wire, with probe by the anaerobe of clinical patients periodontal pocket bacterial plaque Culture fluid is inoculated into fastening knot Cavia porcellus gingival sulcus, within continuous 5 days, causes acute gingivitis model.
Take Cavia porcellus 60, male and female half and half, body weight 425.6 ± 16.5g, be randomly divided into 6 groups by body weight, respectively blank Group (ig distilled water 10ml/kg), model control group (ig distilled water 10ml/kg), Bezoar pill for clearing away the stomach-heat group (ig Bezoar pill for clearing away the stomach-heat 3.8g/kg, for 2 times of clinical equivalent dosage), Chinese medicine extract basic, normal, high dosage group (respectively ig Chinese medicine extract 2.0, 4.0,8.0g/kg, is respectively equivalent to the 1 of clinical equivalent dosage, 2,4 times).In addition to blank group, remaining animal model, institute Having Cavia porcellus in the 1st day every Mus of modeling by table 1 dosed administration, every day 1 time, continuous 5 days, medication was: per os instills, and naturally gulps down Pharynx.Observation index: A, gingivitis are observed.B, take incisor and surrounding tissue soak carries out bacteriology checking.C, take incisor and Surrounding tissue routine paraffin sections, HE dyes, and observes gingiva pathological change: 1. gingiva tissue structure normal (-)；2. gingival epithelium Cover complete, a small amount of vasodilation of lamina propria, be dispersed in a small amount of inflammatory cell infiltration (+)；3. gingival epithelium has no rotten to the corn, lamina propria Inflammatory cell focal infiltration, collagen fiber swelling, vasodilation, congested (++)；4. gingival epithelium ulcer, local is a large amount of Inflammatory necrosis tissue, collagenolysis, inflammation involves mucosa holostrome (+++).
Table 2 Chinese medicine extract is on the gingivitis model guinea pigs incisor bacteriological impact of tissue soak
Through X2Inspection, compares with model control group, * P ＜ 0.05, * * P ＜ 0.01.
Table 3 Chinese medicine extract is on the gingivitis histopathologic impact of model guinea pigs incisor
Check through Ridit, compare with model control group, * P ＜ 0.05
As can be seen from the above table, the Chinese medicine composition that the present invention provides can effectively treat gingivitis.
Chinese medicine extract is used for ulcer treatment
1, material
1.1 laboratory animals: SD rat 60, male and female half and half, body weight 220-250 gram.
1.2 test samples: the powder after the Chinese medicine extract spray drying obtained in embodiment.
1.3 positive drug: YUNNAN BAIYAO (dry powder).
1.4 Experimental agents: glacial acetic acid；Chloral hydrate.
1.5 experimental tools: internal diameter 0.4cm, the glass tubing of long 3cm, exsiccator, Cotton Gossypii, cotton swab, slide gauge, mosquito forceps.
1.6 instruments: Germany's Baeyer 2120 type blood cell analysis machine.
2, method
2.1 oral ulcer modelings: take 50 male and female half and half of Jiankang SD rat, body weight 220-250g.With an internal diameter 0.4cm, long 3cm Glass tubing (an end plug Cotton Gossypii, in case solution spills), in pipe, fill 80% glacial acetic acid, with fill in Cotton Gossypii end in rat lower lip stick Film surface vertically fixes 5 seconds, makes local have blush, has edema, observe after 24 hours, ulcer occurs, and Hypertention is congested, edema is burst Infections face diameter ＞ 3mm person, i.e. model is successfully established.
Ulcer ranking criterion is as follows: remember 1 point without congested, edema ulcer surface diameter ＜ 1mm；Mild hyperaemia, edema, ulcer surface Diameter 1-2mm remembers 2 points；Moderate is congested, edema, and ulcer surface diameter 2-3mm remembers 3 points；Severe is congested, edema ulcer surface diameter ＞ 3mm remembers 4 points.
2.2 rat model random packet administrations: model group (10, male and female half and half) is refused to be administered, the most normal raising, the positive The Chinese medicine extract obtained in medicine group (10, male and female half and half, 0.1g YUNNAN BAIYAO/kg), embodiment be spray-dried after powder (0.1,0.05,0.025g/kg) large, medium and small three dosage groups (often group 10, male and female half and half).By daily single, burst in oral cavity Infections face spray medicine, successive administration three days, observe ulcer healing situation, and note down in detail.Separately set one group of blank group (10, Male and female half and half), not modeling, it is not administered.
2.3 Testing index:
2.3.1 record ulcer healing integration before ulcer rat is given daily.
2.3.2 ulcer rat successive administration is after 3 days, and after the 4th day record ulcer healing integration, rat 10% is hydrated chlorine Aldehyde 0.2ml/100g i.p anaesthetizes, abdominal aortic blood, EDTA anticoagulant, blood count classification and determination.
3, experimental result
Chinese medicine extract is to the Oral ulcer model rat infections mouth healing table of integrals (X ± SD, n=10)
Compare with model group, *: P ＜ 0.05；*: P ＜ 0.01.
As can be seen from the table, the Chinese medicine composition of the present invention can apply to the treatment utilization of oral ulcer.
Tablet formulation checks
Detection project checks with reference to other regulation under tablet item in (two annex I A of China's coastal port).
As can be seen from the table, the tablet that the present invention provides has preferable tabletting performance, and embodiment 4 is by many to Semen sojae atricolor Sugar carries out cross-linking modified, can preferably solve the problem of tabletting sticking and reduce the friability of buccal tablet.

Claims (10)

1. the Chinese medicine composition mainly containing Radix Et Rhizoma Rhei, it is characterised in that include following component by weight: Radix Et Rhizoma Rhei 50～70 parts, Radix Scutellariae 20～35 parts, Radix Sophorae Flavescentis 10～15 parts, Rhizoma Paridis 10～15 parts, Borneolum Syntheticum 1～3 parts, the Radix Rehmanniae 5～15 parts, Flos Lonicerae 15～25 parts, Borax 0.05～0.1 part.
The Chinese medicine composition mainly containing Radix Et Rhizoma Rhei the most according to claim 1, it is characterised in that composition weight is Radix Et Rhizoma Rhei 60 Part, Radix Scutellariae 25 parts, Radix Sophorae Flavescentis 12 parts, Rhizoma Paridis 12 parts, Borneolum Syntheticum 20 parts, 10 parts of the Radix Rehmanniae, Flos Lonicerae 20 parts, Borax 0.05 part.
3. the Chinese medicine extract that the Chinese medicine composition described in claim 1 prepares.
4. the preparation method of the Chinese medicine extract described in claim 3, it is characterised in that comprise the steps: Radix Et Rhizoma Rhei, Huang Boiling 2 times after a kind of reed mentioned in ancient books, Radix Sophorae Flavescentis, Rhizoma Paridis, Borneolum Syntheticum, the Radix Rehmanniae, Flos Lonicerae mixing, the weight that every time adds water is Chinese medicine composition gross weight 6 times, decocting time 1 hour, twice decocting liquid is merged that to filter after medicinal residues concentrating under reduced pressure again be thick paste, obtains Chinese medicine extract.
5. include the medicament of Chinese medicine extract thing described in claim 3.
Medicament the most according to claim 5, it is characterised in that dosage form is buccal tablet.
7. the preparation method of the medicament described in claim 5, it is characterised in that comprise the steps: by weight, by Chinese medicine Extract 40～50 parts are mixed homogeneously with diluent 20～30 parts, obtain particulate matter after drying；By correctives 70～80 parts, bonding After agent 5～10 parts of mixing, adding in particulate matter, add lubricant 4～8 parts, mix homogeneously, after direct compression and get final product.
The preparation method of medicament the most according to claim 7, it is characterised in that described correctives is selected from citric acid, An Sai One or many in honey, menthol, stevioside, glycyrrhizin, aspartame, sucralose, cyclamate, Talin, saccharin Kind.
The preparation method of medicament the most according to claim 7, it is characterised in that described diluent is selected from selected from diluent The mixture of one or more in lactose, Icing Sugar, mannitol, carboxymethyl starch sodium, dextrin, maltose or soybean polysaccharide； It is even more preferred that lactose, dextrin, soybean polysaccharide are according to the mixture of weight ratio 2:3:1, it is still preferred that, soybean polysaccharide refers to Use cross-linking modified soybean polysaccharide；Described binding agent is from PVP K30 ethanol solution, hydroxypropyl methylcellulose, gelatin, list One or more in syrup, ethanol or carbomer；Described lubricant is in magnesium stearate, silicon dioxide and Pulvis Talci one Plant or multiple.
10. the Chinese medicine composition described in claim 1 is used for treating periodontitis, gingivitis, gingival hemorrhage or oral cavity in preparation Application in medicine for ulcer.
CN201610540650.4A 2016-07-11 2016-07-11 A kind of Radix Et Rhizoma Rhei buccal tablets and preparation method thereof Pending CN106177351A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1522720A (en) * 2003-02-20 2004-08-25 彪 羊 Compound traditional Chinese medicine preparation for acute , chronic pharyngitis and tonsillitis
CN102145077A (en) * 2011-03-18 2011-08-10 王磊 Oral Chinese medical preparation for treating acute periodontitis
CN103520502A (en) * 2013-10-18 2014-01-22 李佃场 Chinese medicinal preparation for treating gingivitis and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1522720A (en) * 2003-02-20 2004-08-25 彪 羊 Compound traditional Chinese medicine preparation for acute , chronic pharyngitis and tonsillitis
CN102145077A (en) * 2011-03-18 2011-08-10 王磊 Oral Chinese medical preparation for treating acute periodontitis
CN103520502A (en) * 2013-10-18 2014-01-22 李佃场 Chinese medicinal preparation for treating gingivitis and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
方泰惠等: "口康宁口嚼片抗苯酚性口腔溃疡的疗效观察", 《南京中医药大学学报》 *
熊兴平: "《中国名老中医药专家学术经验集 4》", 31 May 1997, 贵州科技出版社 *

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