CN103705871B

CN103705871B - Be used for the treatment of the Chinese medicine preparation of periodontitis

Info

Publication number: CN103705871B
Application number: CN201410011385.1A
Authority: CN
Inventors: 刘�文; 王燕
Original assignee: Qingdao Municipal Hospital
Current assignee: Qingdao Municipal Hospital
Priority date: 2014-01-10
Filing date: 2014-01-10
Publication date: 2016-04-20
Anticipated expiration: 2034-01-10
Also published as: CN103705871A

Abstract

The invention provides a kind of Chinese medicine preparation being used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.This Chinese medicine preparation therapeutical effect is steady, side effect is little, effectively can improve symptom, improves the quality of life of patient, has no side effect.

Description

Be used for the treatment of the Chinese medicine preparation of periodontitis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine preparation being used for the treatment of periodontitis.

Background technology

Periodontal disease is one of oral cavity common disease, also be the main cause causing oral cavity to lose tooth, it refers to the destructive disease of the chronic progressive external occurred on tooth supporting tissue, the main manifestations of periodontitis local is that tooth follows red and swollen hemorrhage, periodontal pocket formation, pyorrhea, frontal resorption and odontoseisis, finally causes loss of tooth.Modern medicine viewpoint is thought, the dynamic equilibrium that periodontal disease mainly maintains between bacteria attack and host defense is broken caused chronic infectious disease, from local, antibacterial and bacterial plaque are the initiation factors causing periodontal disease, simultaneously systemic factor such as endocrine disturbance, immunodeficiency or changing function reduces defence and the repair ability of host, thus contributes to generation or the development of disease.Have again based on local factor the disease that systemic factor participates in because most of periodontal disease is one, and main based on local to its treatment at present, consider less to the adjustment of whole body fuselage state, cause the clinical therapeutic efficacy being sometimes difficult to obtain satisfaction.

For periodontitis treatment, doctor trained in Western medicine routine uses the method for mechanical removal bacterial plaque and tartar, comprise scaling, scrape control, root planing (Scalingandrootplaning, SRP) etc., be treatment periodontitis, prevent it from recur topmost, simple and effective means.Meanwhile, Drug therapy be coordinated.The Drug therapy of periodontitis comprises systemic drug treatment and topical medications, systemic drug treatment Common Antibiotics, as nitro miaow class medicine, first nitre sound of crying or vomiting, for nitre; Local application mainly contains rinsing the mouth medicine, local painting antiinflammatory astringency, antibacterials flushing, slow release and controlled release local antibacterial medicine.But above Therapeutic Method is Shortcomings part also, on the one hand, conventional therapy comprises scraping under ultrasound wave catches up with scaling, dental caries to be controlled, sometimes therapeutic response is not good, or the scaling repeatedly of some position, scrape control after still poor effect even recur, on the other hand, whole body antibacterials or local antibacterials, the concentration that medicine arrives periodontal local is lower; Long-term efficacy is undesirable, and side effect is more, should not take for a long time, and the Drug resistance of pathogenic microorganism constantly strengthens in recent years in addition, and antibiotic curative effect reduces day by day, and heavy dose of long-time use easily causes dysbacteriosis, and inducible resistance bacterial strain produces; Easy generation systemic anaphylaxis, gastrointestinal side effect etc., while eliminating bacteria, also been proposed the Therapeutic Method regulating host defense function in recent years, namely blocks some bioactive substances that host produces.But majority is zooscopy, or the clinical evidence lacking large sample amount confirms its effectiveness and safety.

Theory of Chinese medical science thinks periodontitis mainly caused by the red-hot or insufficiency of vital energy and blood of kidney qi virtual loss, stomach-fire.Kidney governing bones, tooth is She of bone, and tooth is supplemented nutrition by kidney qi, enter upper gums outside stomach channel of foot-Yang-ming per nasal, the large intesting channel of Hand-Yangming enters lower gums through cervical region to buccal, and gingiva is then closely related with gastrointestinal function, once there is stomach-QI being unable to descend normally, intestinal is lost leads, then foul smell and dampness are smoked in mouth, itself has made odontopathy and periodontal disease easily send out, there is the reason that exopathogen six climate exopathogens, interior evil seven emotions and wound are polluted again, positive exogenous pathogen enters, and whole body is combined with Local Phase, thus finally causes periodontal disease.

The treatment of the traditional Chinese medical science is often conceived to overall regulating action, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and " strengthening the body resistance " emphasis local contacts with whole body, payes attention to the disease-resistant potential playing human body.There is good therapeutic effect improving in tcm syndrome.Treatment by Chinese herbs effect is steady, side effect is little, effectively can improve symptom, improves the quality of life of patient, adopts Chinese medicine periodontitis curative effect progressively to obtain certainly, not finding side effect.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicine preparation being used for the treatment of periodontitis, and its therapeutical effect is steady, side effect is little, effectively can improve symptom, improves the quality of life of patient, has no side effect.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation being used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 53g ~ 63g, Fructus Viticis 20g ~ 30g, Rhizoma Anemarrhenae 32g ~ 42g, Cortex Moutan 27g ~ 37g, Herba Houttuyniae 31g ~ 41g, Caulis Spatholobi 39g ~ 49g, Herba Ecliptae 35g ~ 45g, Radix Scrophulariae 29g ~ 39g, Semen Cuscutae 34g ~ 44g, Rhizoma Polygonati 52g ~ 62g, Radix Paeoniae Rubra 29g ~ 39g, Radix Et Rhizoma Rhei 31g ~ 41g, Rhizoma Polygoni Cuspidati 33g ~ 43g, Radix Changii 26g ~ 36g, Radix Glycyrrhizae 21g ~ 31g, Radix Gentianae Macrophyllae 16g ~ 26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g ~ 32g, Ramulus Cinnamomi 17g ~ 27g, Rhizoma Curcumae Longae 29g ~ 39g, Herba Selaginellae 36g ~ 46g, Herba Taxilli 27g ~ 37g, Radix Morindae Officinalis 25g ~ 35g, Caulis et folium cryptotaeniae japonicae 33g ~ 43g, Caulis Bauhihiae Championii 22g ~ 32g, Caulis Lonicerae 29g ~ 39g, Fructus Corni 23g ~ 33g, Cortex Acanthopancis 41g ~ 51g, achillea millefolium 22g ~ 32g, Herba Rabdosiae glaucocalycis 27g ~ 37g, Herba Asteris Ageratoidis 19g ~ 29g, Herba Cistanches 35g ~ 45g, Rhizoma Cimicifugae 27g ~ 37g and Rhizoma Panacis Japonici 36g ~ 46g.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g ~ 60g, Fructus Viticis 23g ~ 27g, Rhizoma Anemarrhenae 35g ~ 39g, Cortex Moutan 30g ~ 34g, Herba Houttuyniae 34g ~ 38g, Caulis Spatholobi 42g ~ 46g, Herba Ecliptae 38g ~ 42g, Radix Scrophulariae 32g ~ 36g, Semen Cuscutae 37g ~ 41g, Rhizoma Polygonati 55g ~ 59g, Radix Paeoniae Rubra 32g ~ 36g, Radix Et Rhizoma Rhei 34g ~ 38g, Rhizoma Polygoni Cuspidati 36g ~ 40g, Radix Changii 29g ~ 33g, Radix Glycyrrhizae 24g ~ 28g, Radix Gentianae Macrophyllae 19g ~ 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g ~ 29g, Ramulus Cinnamomi 20g ~ 24g, Rhizoma Curcumae Longae 32g ~ 36g, Herba Selaginellae 39g ~ 43g, Herba Taxilli 30g ~ 34g, Radix Morindae Officinalis 28g ~ 32g, Caulis et folium cryptotaeniae japonicae 36g ~ 40g, Caulis Bauhihiae Championii 25g ~ 29g, Caulis Lonicerae 32g ~ 36g, Fructus Corni 26g ~ 30g, Cortex Acanthopancis 44g ~ 48g, achillea millefolium 25g ~ 29g, Herba Rabdosiae glaucocalycis 30g ~ 34g, Herba Asteris Ageratoidis 22g ~ 26g, Herba Cistanches 38g ~ 42g, Rhizoma Cimicifugae 30g ~ 34g and Rhizoma Panacis Japonici 39g ~ 43g.

Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

Wherein, the dosage form of described Chinese medicine preparation is powder and oral liquid.

Wherein, the powder that described Chinese medicine preparation is prepared into adopts mode for oral administration, every day 3 times, each 100g.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the powder that described Chinese medicine preparation is prepared into, be specially:

The first step, Rhizoma Drynariae, Cortex Moutan, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Morindae Officinalis, Fructus Corni, Cortex Acanthopancis, Herba Cistanches and Rhizoma Panacis Japonici are pulverized respectively, mix by weight, obtain mixture, adding relative to mixture quality 4 ~ 6 times of determining alcohols is in the ethanol of 70% ~ 80%, flood 24 hours ~ 36 hours, adopt percolation with the speed of 2 ~ 4ml per minute slowly percolation, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder;

Second step, pulverizes component under She respectively, mixes by weight, add in cold water and soak 3 hours ~ 5 hours, with slow fire boiling 2 hours ~ 3 hours, the quality of the cold water added was 2 ~ 4 times of the mixture quality that the first step obtains, decoction liquor filtered, filtering residue put into cold water again, with slow fire boiling 1 hour ~ 2 hours, the quality of the cold water added is 1 ~ 2 times of the mixture quality that the first step obtains, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing that the first step and second step are obtained, relative to the protein sugar of its quality 0.01 ~ 0.05 times, the dextrin of 0.1 ~ 0.2 times, the starch of 1 ~ 2 times is put into blender and is stirred 30 minutes ~ 1 hour, namely powder is made, with racking machine subpackage.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the oral liquid that described Chinese medicine preparation is prepared into, be specially:

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Present invention also offers a kind of Chinese powder medicine being used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Present invention also offers a kind of Chinese medicine oral liquid being used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Beneficial effect of the present invention:

Chinese medicine preparation therapeutical effect provided by the invention is steady, side effect is little, effectively can improve symptom, improves the quality of life of patient, has no side effect.

Detailed description of the invention

Periodontitis belongs to the category such as the traditional Chinese medical science " gingival atrophy ", " tooth maggot ", " teeth shake ", " wind skin ulcer ", " food bed ".Motherland's medical science, by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, thinks that the Etiological of gingival atrophy is roughly as follows: one, the pungent delicious food savoury of vegetarian diet, eating and drinking without temperance, disorder of the spleen and stomach caused by internal damage, intrinsic heat fire-transformation, and its heat is followed and made through upper steaming tooth.Said as " bright doctor's pragma ": " the intestines and stomach is hindered in good wine, savoury, fat meat and fine grain, sweet greasy thing, thus damp and hot on attack, then dental bed unclear and for swelling, for pain or hemorrhage or infested.By being that tooth can not be pacified and shaken, black rotten de-also, common people's opinion of all suffering from a deficiency of the kidney is controlled.Hardly realize that this belongs to Yangming Channel damp and hot.Though tooth belongs to kidney and is born in dental bed, upper mandible belongs to positive bright large intestine and gastrointestinal.Stomach hinders the thing in good wine, savoury, fat meat and fine grain, sweet cunning, thus damp and hot on attack, then dental bed is unclear and for swelling as pain, or hemorrhage, or infested, by being that tooth can not be pacified and shaken, blackly rottenly to come off also ".As " surgery pandect " is pointed out: " gingival atrophy meaning spleen pathogenic heat in the stomach gushes and Xuan Luye ".And for example " treatise on blood trouble tooth sail " is said: " dental bed particularly stomach through venation institute around, therefore all maggot blood is all flaming up of stomach-fire, and blood moves with fire, and method for the treatment of is to clear up stomach-fire ".

Two, deficiency of the kidney, hyperactivity of fire caused by deficiency of YIN, hyperactivity of deficient fire.Wang Bing says: " in bone, tooth is bone She to kidney master, and kidney qi both declined, essence without support, therefore make trichomadesis, tooth dries up again." Shen Jinao says: " tooth person, the mark of kidney, the basis of bone are also.Tooth is brothers' Yangming Channel institute mistake again, and upper tooth is subordinate to female soil, stomach of foot Yang Ming arteries and veins pass through network also ~ ... lower tooth belongs to the bright large intestine venation of hands sun also." Ming Dynasty ZHANG Jie bin points out in Jing-Yue Complete Works: " institute that lid tooth is bone eventually, and kidney master is in bone also, therefore says renal failure then tooth and gap, the solid then tooth of essence is hard, be disease to it, then all teeth are crisp not hard, or are easy to shake, or dredge open-minded, or it is prominent and unreal ... allly can't help worm and can't help fire and toothache person, must deficiency of kidney-QI, this then lost by congenital examining or by the day after tomorrow with funeral, all can cause it, be work as based on special the kidney invigorating gas.”

Three, insufficiency of vital energy and blood: ferritic is weak, or prolonged illness consumption wound, insufficiency of vital energy and blood, it is micro-in heel to go up semen deposition, and tooth is caused by meat loses and supports.Decline by containing in the kidney qi in life of people, ' deficiency of the kidney yin then hyperactivity of deficient fire, causes hyperactivity of fire caused by deficiency of YIN, thus occurs that neuroendocrine-immune network regulatory function is low; Gastrointestinal function is by by force to weak, and stomach-QI being unable to descend normally, intestinal are lost leads, then foul smell and damp and hot on smoke, itself made odontopathy and periodontitis easily send out, then had exopathogen six climate exopathogens, interior evil seven emotions and the reason such as wound, pollution, positive exogenous pathogen enters, whole body is combined with local factor, thus finally causes the generation of periodontitis.Tooth is led by kidney, and upper mandible belongs to negative and positive large intestine stomach function regulating warp, and tooth and heel all need moistening of vim and vigour foster, therefore primary disease can be caused by the factor such as steaming, vital essence virtual loss, insufficiency of vital energy and blood in stomach-fire.Stomach internal organs accumulated heat, positive naked light is vehement, damp and hotly fumigates in upper and form gingival atrophy; Nephrons is deficient, kidney governing bones, and tooth is She of bone, deficiency of the kidney, can not on reach, tooth loses and moistens foster, causes odontoseisis, and tooth is with atrophy; Deficiency of qi and blood, dental caries is lost and is supported, and pathogenic factor is invaded, and visitor to cause between cog that tooth spawns blood, atrophy, root of the tooth appear, loosen.

The present invention with heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, nourishing kidney clearing stomach for Therapeutic Principle, there is provided a kind of Chinese medicine preparation being used for the treatment of periodontitis, its crude drug comprises Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici.

Further, described Chinese medicine preparation is only made up of above-mentioned raw materials medicine.

In described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 53g ~ 63g, Fructus Viticis 20g ~ 30g, Rhizoma Anemarrhenae 32g ~ 42g, Cortex Moutan 27g ~ 37g, Herba Houttuyniae 31g ~ 41g, Caulis Spatholobi 39g ~ 49g, Herba Ecliptae 35g ~ 45g, Radix Scrophulariae 29g ~ 39g, Semen Cuscutae 34g ~ 44g, Rhizoma Polygonati 52g ~ 62g, Radix Paeoniae Rubra 29g ~ 39g, Radix Et Rhizoma Rhei 31g ~ 41g, Rhizoma Polygoni Cuspidati 33g ~ 43g, Radix Changii 26g ~ 36g, Radix Glycyrrhizae 21g ~ 31g, Radix Gentianae Macrophyllae 16g ~ 26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g ~ 32g, Ramulus Cinnamomi 17g ~ 27g, Rhizoma Curcumae Longae 29g ~ 39g, Herba Selaginellae 36g ~ 46g, Herba Taxilli 27g ~ 37g, Radix Morindae Officinalis 25g ~ 35g, Caulis et folium cryptotaeniae japonicae 33g ~ 43g, Caulis Bauhihiae Championii 22g ~ 32g, Caulis Lonicerae 29g ~ 39g, Fructus Corni 23g ~ 33g, Cortex Acanthopancis 41g ~ 51g, achillea millefolium 22g ~ 32g, Herba Rabdosiae glaucocalycis 27g ~ 37g, Herba Asteris Ageratoidis 19g ~ 29g, Herba Cistanches 35g ~ 45g, Rhizoma Cimicifugae 27g ~ 37g and Rhizoma Panacis Japonici 36g ~ 46g.

Further, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g ~ 60g, Fructus Viticis 23g ~ 27g, Rhizoma Anemarrhenae 35g ~ 39g, Cortex Moutan 30g ~ 34g, Herba Houttuyniae 34g ~ 38g, Caulis Spatholobi 42g ~ 46g, Herba Ecliptae 38g ~ 42g, Radix Scrophulariae 32g ~ 36g, Semen Cuscutae 37g ~ 41g, Rhizoma Polygonati 55g ~ 59g, Radix Paeoniae Rubra 32g ~ 36g, Radix Et Rhizoma Rhei 34g ~ 38g, Rhizoma Polygoni Cuspidati 36g ~ 40g, Radix Changii 29g ~ 33g, Radix Glycyrrhizae 24g ~ 28g, Radix Gentianae Macrophyllae 19g ~ 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g ~ 29g, Ramulus Cinnamomi 20g ~ 24g, Rhizoma Curcumae Longae 32g ~ 36g, Herba Selaginellae 39g ~ 43g, Herba Taxilli 30g ~ 34g, Radix Morindae Officinalis 28g ~ 32g, Caulis et folium cryptotaeniae japonicae 36g ~ 40g, Caulis Bauhihiae Championii 25g ~ 29g, Caulis Lonicerae 32g ~ 36g, Fructus Corni 26g ~ 30g, Cortex Acanthopancis 44g ~ 48g, achillea millefolium 25g ~ 29g, Herba Rabdosiae glaucocalycis 30g ~ 34g, Herba Asteris Ageratoidis 22g ~ 26g, Herba Cistanches 38g ~ 42g, Rhizoma Cimicifugae 30g ~ 34g and Rhizoma Panacis Japonici 39g ~ 43g.

Most preferably, in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

In described Chinese medicine preparation, the pharmacology of each crude drug is as follows:

Rhizoma Drynariae: bitter in the mouth, warm in nature, enter liver, kidney channel, there is invigorating the kidney and strengthening the bones, continuous effect of hindering pain relieving, for soreness of waist and knee joint of suffering from a deficiency of the kidney, flaccidity and weakness of the lower limbs, the hepatic and renal YIN deficiency, empty positive rising and the deafness and tinnitus that causes, odontoseisis pain or gingival hemorrhage, asthenia of both the spleen and kidney and cause the cards such as chronic diarrhea chronic dysentery.

Fructus Viticis: acrid in the mouth, hardship, cold nature, returns bladder, liver, stomach warp, has dispelling wind and heat pathogens, effect of the clear sharp head, cures mainly anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, the card such as to have a dizzy spell.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, have rush down clearly stomach-fire, relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire, the Rhizoma Anemarrhenae has inhibitory action to various bacteria such as dysentery bacterium, Bacillus typhi, escherichia coli, Bacillus proteus, staphylococcus, streptococcus.

Cortex Moutan: cold in nature, bitter in the mouth, cool, enter the heart, liver, kidney, lung meridian, there is effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury, the cards such as beriberoid pyretic arthralgia.

Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, and for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, and snakeworm wants first-class card.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, return liver, kidney channel, have blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cure mainly the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.

Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell caused by the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.

Radix Scrophulariae: sweet in the mouth, hardship, one-tenth, cold nature, returns lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing supports effect of kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the symptoms such as aqueous-grainy diarrhea, by adding Semen Cuscutae, promote the reparation of liver and kidney cells, nourishing kidney-yin, protecting liver and detoxication, enhances metabolism, slow down epidemic situation, strengthen resistance against diseases, reduce miscarriage simultaneously, produce the generation of stillborn fetus, weak tire or mummy tire.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, returns Liver Channel, has removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain of high liver fire, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, and macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Various pain caused by blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.

Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, returns liver, gallbladder, lung meridian, has the effect of expelling wind and removing dampness, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing, for arthralgia, and jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.

Radix Changii: sweet in the mouth, micro-hardship, cold nature, returns lung, spleen, Liver Channel, has moistening the lung and resolving phlegm, yin nourishing stomach function regulating, effect of suppressing the hyperactive liver removing toxic substances, for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, the cards such as conjunctival congestion is dizzy, furunculosis skin infection.

Radix Glycyrrhizae: sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

Radix Gentianae Macrophyllae: acrid in the mouth, hardship, cold nature, return stomach warp, Liver Channel, gallbladder meridian, have wind-damp dispelling, relaxing muscles and tendons network, effect of clearind deficient heat, cures mainly rheumatic arthralgia, the contracture of muscle arteries and veins, the cards such as joint is ached, afternoon fever, infantile malnutrition heating.

Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): the flower of Rubiaceae Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) platymiscium Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), sweet in the mouth, light, cool in nature, have dissipating blood stasis hemostasis, regulating menstruation, blood pressure lowering, liver heat removing, invigorates blood circulation, and effect of pain relieving, cures mainly hypertension, menoxenia, injured bone, skin infection.Root, stem: hemoptysis of pulmonary tuberculosis, stomachache, rheumatic arthritis, the cards such as traumatic injury.

Ramulus Cinnamomi: be the dry twig warming the meridian and promoting blood circulation of canella Cortex Cinnamomi, acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, there is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, effect of dispersing cold for relieving pain, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can to apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, cough with dyspnea dizziness waits phlegm retention syndrome.

Rhizoma Curcumae Longae: bitter in the mouth, pungent, warm in nature, enters Liver Channel, has removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia, twinges, amenorrhea, lump in the abdomen for the breast side of body, rheumatism shoulder arm pain, the cards such as tumbling and swelling.

Herba Selaginellae: be the dry herb of Spikemoss plant Herba Selaginellae or Selaginella pulvinata, acrid in the mouth, property is put down, and returns liver, heart channel, has effect of promoting blood circulation to restore menstrual flow, and for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.

Herba Taxilli: bitter in the mouth, sweet, property is put down, and returns liver, kidney channel, have effect of invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, cure mainly the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood void is lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.

Radix Morindae Officinalis: acrid in the mouth, sweet, warm in nature, returns liver, kidney channel, has reinforcing the kidney and supporting YANG; Bone and muscle strengthening; Effect of expelling wind and removing dampness, cures mainly impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; The cards such as rheumatism limb gas.

Caulis et folium cryptotaeniae japonicae: acrid in the mouth is bitter; Property is put down, and has dispelling wind stopping cough; Eliminating damp, detoxifying; Effect of blood-activating analgetic, cures mainly pneumonia, pulmonary abscess, gonorrhea, hernia, acute toothache, and carbuncle furuncle swells, herpes zoster, the cards such as skin pruritus.

Caulis Bauhihiae Championii: bitter in the mouth, pungent, property is put down, and have expelling wind and removing dampness, effect of promoting flow of QI and blood, cures mainly rheumatic arthralgia, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, the cards such as dysentery.

Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral, cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the cards such as redness and swelling of joints burning pain.

Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat such as to be quenched one's thirst at the card.

Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney, there is wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; To invigorate blood circulation effect of arteries and veins, cure mainly anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination such as to be itched at the card.

Achillea millefolium: acrid in the mouth; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainly cold, fever; Wind syndrome of head pain; Toothache; Rheumatic arthralgia; Blood stasis amenorrhea; Abdominal part mass in the abdomen; Traumatic injury; Venom; The cards such as carbuncle sore tumefacting virus.

Herba Rabdosiae glaucocalycis: bitter in the mouth, pungent, gas is fragrant, and cool in nature, GUIXIN, liver, spleen channel, have clearing away heat-damp and promoting diuresis, and effect of promoting blood circulation and detoxication, cures mainly jaundice due to damp-heat, stranguria, edema, laryngopharynx swelling and pain, arthralgia, amenorrhea, acute mastitis, hemorrhoid, traumatic injury, the cards such as venom.

Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, have heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the cards such as snake bite and insect sting.

Herba Cistanches: sweet in the mouth, one-tenth, warm in nature, enter kidney, large intestine channel, have kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, deficiency of body fluid after being ill the card such as constipation.

Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has and deliver rash, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, the cards such as uterine prolapse.

Rhizoma Panacis Japonici: sweet in the mouth, micro-hardship, warm in nature, return liver, spleen, lung meridian, have strengthening by means of tonics, eliminating stasis to stop pain, effect of eliminating the phlegm of stopping blooding, cure mainly weak after being ill, chronic cough is spat blood, cough with copious phlegm, the cards such as injury from falling down.

Described Chinese medicine preparation can be prepared into powder and oral liquid.

Present invention also offers the powder that above-mentioned Chinese medicine preparation is prepared into, be specially:

3rd step, the powder mixing that the first step and second step are obtained, add the protein sugar relative to its quality 0.01 ~ 0.05 times, the dextrin of 0.1 ~ 0.2 times, the starch of 1 ~ 2 times is put into blender and is stirred 30 minutes ~ 1 hour, namely powder is made, with racking machine subpackage.

The oral liquid that the present invention also provides above-mentioned Chinese medicine preparation to be prepared into, is specially:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 powder 1

By Rhizoma Drynariae 58g, Cortex Moutan 32g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Morindae Officinalis 30g, Fructus Corni 28g, Cortex Acanthopancis 46g, Herba Cistanches 40g and Rhizoma Panacis Japonici 41g mixes, and obtain mixture, adding 2.6kg determining alcohol is in the ethanol of 80%, floods 36 hours, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Herba Houttuyniae 36g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Rhizoma Cimicifugae 32g pulverizes respectively, mixing, adds in 1.8kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor filtered, filtering residue put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, by the powder mixing obtained, add 20g protein sugar above, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, namely makes powder 1, with racking machine subpackage.

Toxicological experiment

Acute toxicity test in mice conclusion: be dissolved in water by powder prepared by embodiment 1, obtain the solution of 1g/ml, gavage does not measure LD after giving ICR mice ₅₀, recording maximum dosage-feeding is 48g medicated powder/kg, is equivalent to 150g crude drug/kg, is 750 times that intend clinical people's dosage.

Rat chronic toxicity test

With rat 120,4 groups are divided at random by body weight sex, often organize 30, male and female half and half, with Chinese powder medicine 1, maximum dosage-feeding 7.2g medicated powder/kg is as the heavy dose of rat chronic toxicity test, and three dosage are respectively 7.2g medicated powder/kg, 3.6g medicated powder/kg, 1.8g medicated powder/kg, is equivalent to 122.5 times, 56.2 times, 28.1 times that intend quantity.Gavage awards rat 180 days, every day gastric infusion once, Per-Hop behavior 6 days.

1. to the observation of rat general status: administration group and control rats are all movable normal within 6 months experimental periods and convalescent period, and behavior is active, and hair is smooth, has no feces abnormal, without the pathological change such as secretions and dyspnea.

2. on the impact of rat body weight: comparatively, Some Animals loses weight for Chinese medicine preparation provided by the invention three dosage groups and control animals weight ratio.

3. on the impact of rat food ration and water uptake: administration treated animal food ration and water uptake and control animals change basically identical.

4. on the impact of Rats Organs and Tissues coefficient: the heart, liver, spleen, lung, kidney, brain, adrenal gland, thymus, testis, prostate, ovary, uterus organ coefficient statistics compare with water matched group, unknown significance difference.

5. on the impact of rat blood index: administration group hematological indices compares with matched group, leukocyte differential count compares with matched group, difference has significance (P<0.05, P<0.01), but all within normal range (normal range: lymphocyte 66%-84%, neutrophil(e) cell 9%-34%), therefore abiology meaning.Administration after 3 months erythrocyte and reticulocyte compare with matched group, significantly raise (P<0.05, P<0.01), but fluctuation range is less, administration 6 months and convalescent period no significant difference, belong to normal physiology fluctuation, abiology meaning.In convalescent period, dosage HGB and PLT compares with matched group significant difference (P<0.05, P<0.01), but fluctuation range is less, belongs to the fluctuation of normal physiology, abiology meaning.Other hematological indices Non Apparent Abnormalities.

6. on the impact of rat blood biochemical indicator: administration group blood parameters compares with matched group, administration 3 months, in this product, dosage ALT significantly reduces (P<0.01), the Cr of heavy dose of and middle dosage significantly reduces (P<0.01, P<0.05), administration 3 months and convalescent period, the GLU of heavy dose of and middle dosage has fluctuation (P<0.01, P<0.05), from data, amplitude of variation is very little, belongs to the fluctuation of normal physiology, abiology meaning.This product has no significant effect rat blood biochemical indicator.

7. to the inspection of rat histopathology: to administration 3 months, the matched group that 6 months and drug withdrawal convalescent period put to death and all internal organs of heavy dose of treated animal and tissue have carried out comprehensive and systematic histological observation, and by heavy dose of group and matched group paired observation, think the heart of Chinese medicine preparation provided by the invention to rat, kidney, spleen, brain, hypophysis, adrenal gland, thymus, thyroid, pancreas, stomach, duodenum, ileum, colon, testis, prostate, bladder, uterus, ovary, mesenteric lymph node, breast bone, spinal cord, optic nervies etc. are without pathologic damaging action, hepatocyte edema occurs matched group and heavy dose of group, may have nothing to do with administration, matched group and heavy dose of group all have interstitial pneumonia to distribute, and how to be caused by viral infection, and have nothing to do with administration.In conjunction with hematological indices and blood biochemical analysis index known: Chinese medicine preparation provided by the invention to the various organs and tissues of rat without pathologic damaging action.

Conclusion: result of the test shows, under this experimental condition, Chinese medicine preparation provided by the invention all has no significant effect the ordinary circumstance of rat, diet drinking-water, hematology, blood biochemical analysis, Systematic anatomy, organ coefficient and histopathology, Some Animals loses weight, do not find that obvious long term toxicity reacts, convalescent period is also without retardance toxic reaction, result is pointed out: Chinese medicine preparation gavage provided by the invention gives rat 180 days, rat nontoxic crude protein is 7.2g medicated powder/kg day, 19.1g crude drug/kg day.

Toxicological experiment shows that this product has certain safety, and taking convenience safely, has no side effect, and drug effect is clear and definite, have significant clinical application prospect.

Embodiment 2 powder 2

By Rhizoma Drynariae 56g, Cortex Moutan 30g, Caulis Spatholobi 42g, Herba Ecliptae 38g, Radix Scrophulariae 32g, Semen Cuscutae 37g, Rhizoma Polygonati 55g, Radix Paeoniae Rubra 32g, Radix Morindae Officinalis 28g, Fructus Corni 26g, Cortex Acanthopancis 44g, Herba Cistanches 38g and Rhizoma Panacis Japonici 39g mixes, and obtain mixture, adding 2.5kg determining alcohol is in the ethanol of 80%, floods 36 hours, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 23g, Rhizoma Anemarrhenae 35g, Herba Houttuyniae 34g, Radix Et Rhizoma Rhei 34g, Rhizoma Polygoni Cuspidati 36g, Radix Changii 29g, Radix Glycyrrhizae 24g, Radix Gentianae Macrophyllae 19g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g, Ramulus Cinnamomi 20g, Rhizoma Curcumae Longae 32g, Herba Selaginellae 39g, Herba Taxilli 30g, Caulis et folium cryptotaeniae japonicae 36g, Caulis Bauhihiae Championii 25g, Caulis Lonicerae 32g, achillea millefolium 25g, Herba Rabdosiae glaucocalycis 30g, Herba Asteris Ageratoidis 22g, Rhizoma Cimicifugae 30g pulverizes respectively, mixing, adds in 1.8kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor filtered, filtering residue put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, by the powder mixing obtained, add 20g protein sugar above, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, namely makes powder 2, with racking machine subpackage.

Embodiment 3 powder 3

By Rhizoma Drynariae 60g, Cortex Moutan 34g, Caulis Spatholobi 46g, Herba Ecliptae 42g, Radix Scrophulariae 36g, Semen Cuscutae 41g, Rhizoma Polygonati 59g, Radix Paeoniae Rubra 36g, Radix Morindae Officinalis 32g, Fructus Corni 30g, Cortex Acanthopancis 48g, Herba Cistanches 42g and Rhizoma Panacis Japonici 43g mixes, and obtain mixture, adding 2.6kg determining alcohol is in the ethanol of 80%, floods 36 hours, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 27g, Rhizoma Anemarrhenae 39g, Herba Houttuyniae 38g, Radix Et Rhizoma Rhei 38g, Rhizoma Polygoni Cuspidati 40g, Radix Changii 33g, Radix Glycyrrhizae 28g, Radix Gentianae Macrophyllae 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 29g, Ramulus Cinnamomi 24g, Rhizoma Curcumae Longae 36g, Herba Selaginellae 43g, Herba Taxilli 34g, Caulis et folium cryptotaeniae japonicae 40g, Caulis Bauhihiae Championii 29g, Caulis Lonicerae 36g, achillea millefolium 29g, Herba Rabdosiae glaucocalycis 34g, Herba Asteris Ageratoidis 26g, Rhizoma Cimicifugae 34g pulverizes respectively, mixing, adds in 2kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor filtered, filtering residue put into 1kg cold water again, with slow fire boiling 2 hours, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder, by the powder mixing obtained, add 20g protein sugar above, 150g dextrin, the starch of 1.5kg is put into blender and is stirred 1 hour, namely makes powder 3, with racking machine subpackage.

Embodiment 4 oral liquid

By Rhizoma Drynariae 60g, Cortex Moutan 34g, Caulis Spatholobi 46g, Herba Ecliptae 42g, Radix Scrophulariae 36g, Semen Cuscutae 41g, Rhizoma Polygonati 59g, Radix Paeoniae Rubra 36g, Radix Morindae Officinalis 32g, Fructus Corni 30g, Cortex Acanthopancis 48g, Herba Cistanches 42g and Rhizoma Panacis Japonici 43g mixes, and obtain mixture, adding 2.6kg determining alcohol is in the ethanol of 80%, floods 36 hours, adopt percolation with the speed of 3ml per minute slowly percolation, collect percolate, percolate concentrating under reduced pressure, obtain and get dry extract, be ground into powder, by Fructus Viticis 27g, Rhizoma Anemarrhenae 39g, Herba Houttuyniae 38g, Radix Et Rhizoma Rhei 38g, Rhizoma Polygoni Cuspidati 40g, Radix Changii 33g, Radix Glycyrrhizae 28g, Radix Gentianae Macrophyllae 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 29g, Ramulus Cinnamomi 24g, Rhizoma Curcumae Longae 36g, Herba Selaginellae 43g, Herba Taxilli 34g, Caulis et folium cryptotaeniae japonicae 40g, Caulis Bauhihiae Championii 29g, Caulis Lonicerae 36g, achillea millefolium 29g, Herba Rabdosiae glaucocalycis 34g, Herba Asteris Ageratoidis 26g, Rhizoma Cimicifugae 34g pulverizes respectively, mixing, adds in 2kg cold water and soaks 4 hours, with slow fire boiling 3 hours, decoction liquor filtered, filtering residue puts into 1kg cold water again, with slow fire boiling 2 hours, merges filtrate, concentrating under reduced pressure, except anhydrating, obtaining and getting dry extract, be ground into powder, by the powder mixing obtained above, obtain 500g powder, add 2kg distilled water, the sucrose of 70g, the sodium benzoate of 7g, stirs, boils, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Embodiment 5 clinical data

Physical data

Select patients with periodontitis totally 180 examples, adopt random digits table that patient is divided into two groups at random, each 90 examples, 36 ~ 54 years old treatment group age, average 46.2 years old, the course of disease 6 months ~ 6 years; Matched group 90 example, 38 ~ 54 years old age, average 46.5 years old, the course of disease 5 months ~ 6 years; Two groups of patients in age, sex, the course of disease no significant difference ((P>0.05), has comparability.

Therapeutic Method

Matched group: topical therapeutic comprises scaling on gum, subgingival debridement, 3%H ₂o ₂periodontal pocket rinses root planing, adjustment is grited one's teeth, and conjunction removal is extremely made a concerted effort, pulled out the trouble tooth that can not retain, oral hygiene guidance etc.Whole body therapeutic comprise Metronidazole Tablet and oral 1 month of Levofloxacin Hydrochloride Capsules (Metronidazole Tablet, Beijing dawn Pharmaceutical responsibility company limited, the accurate word H11021060 of traditional Chinese medicines, every sheet 0.1g, each 0.2g, every day 2 times, oral; Levofloxacin Hydrochloride Capsules, Yangzijiang Pharmaceutical Group Co., Ltd, the accurate word H19990051 of traditional Chinese medicines, every sheet 0.1g, each 0.2g, every day 2 times, oral).

Treatment group: topical therapeutic comprises scaling on gum, subgingival debridement, 3%H ₂o ₂periodontal pocket rinses root planing, adjustment is grited one's teeth, and conjunction removal is extremely made a concerted effort, pulled out the trouble tooth that can not retain, oral hygiene guidance etc.Whole body therapeutic comprises the powder 1 of the oral embodiment of the present invention 1 preparation, is dissolved in water, oral, every day 3 times, each 100g.

Two groups was all 1 course for the treatment of with 1 month, serve on 2 courses for the treatment of.

Observation index

Gingival index (GI) classification: 0 grade: gingiva is normal; 1 grade: gingiva mild inflammation, gum edge color and luster changes, and spy is examined not hemorrhage; 2 grades: moderate inflammation, red swelling of gingiva involves attached gingiva, and spy is examined hemorrhage; 3 grades: hyperphlogosis, gingiva is obviously red and swollen rotten to the corn, spontaneous hemorrhage.

Periodontal pocket PD

Measure with periodontal probe, suffer from the depth of pocket that tooth each facing is the darkest, the most degree of depth of periodontal pocket measuring identical diseased region during further consultation with millimeter (mm) for unit.

The plaque index (Plaqueindex, PLI) of every tooth divides 4 grades

0 grade: without bacterial plaque on the facing at nearly gum edge place; 1 grade: be invisible to the naked eye, time on the facing streaking nearly free gum district with the side of probe pinpoint, thin bacterial plaque could be found; 2 grades: have macroscopic moderate bacterial plaque in Yin Yuan district or tooth proximal surface; 3 grades: in gingival sulcus and (or) Yin Yuan district and contiguous facing have a large amount of bacterial plaque to pile up.

Sulcular bleeding index (SBI) divides 6 grades

0 grade: gums healthy, visit and examine without hemorrhage; 1 grade: spy is examined hemorrhage, and gum nipple and marginal gingiva are without edema and color change; 2 grades: spy is examined hemorrhage, and gum nipple and marginal gingiva have color change, without edema; 3 grades: spy is examined hemorrhage, gum nipple and marginal gingiva color change, Mild edema; 4 grades: spy is examined rear hemorrhage, gum nipple and marginal gingiva color change, obvious edema; 5 grades: spy is examined hemorrhage, there are spontaneous hemorrhage and color change and edema.

Criterion of therapeutical effect

Effective: pain disappears, and General Symptoms significantly alleviates, local red swelling of gingiva disappears, and without rheuminess thing, odontoseisis II degree transfers I degree to, and gingival atrophy is without significant change.Effective: dental pain disappears, and General Symptoms alleviates, and red swelling of gingiva significantly alleviates, and substantially without inflammatory exudate, odontoseisis alleviates, and gingival atrophy is unchanged.Invalid: before treatment, but general without increasing the weight of situation.

Statistical method

SPSS14.0 software is adopted to add up.Compare with t inspection between the group of measurement data, ranked data rank test.

Result

Comparitive study, the results are shown in Table 1.

A table 1 liang group therapeutic effect compares

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Treatment group	90	49	33	8	91.1％
Matched group	90	23	35	32	64.4％

As can be seen from Table 1, the successful of Chinese medicine preparation of the present invention is adopted to be better than matched group, P<0.01.

Before and after two groups of patient treatments, every periodontal Indexes Comparison, the results are shown in Table 2.

Every periodontal Indexes Comparison before and after table 2 liang group patient treatment

Group

Time

Number of cases

GI

SBI

PD(mm)

PLI

Treatment group

Before treatment

90

2.21±0.67

2.43±0.12

5.92±0.41

2.91±0.37

After treatment

90

0.32±0.17

1.03±0.15

4.17±0.24

0.39±0.14

Matched group

Before treatment

90

2.34±0.76

2.52±0.18

6.09±0.48

2.87±0.72

After treatment

90

1.26±0.25

1.76±0.33

5.08±0.43

1.22±0.17

Table 2 shows, all has decline (P<0.05) before GI, SBI, PD and PLI after two groups of treatments comparatively treat; GI, SBI, PD and PLI for the treatment of group all comparatively matched group reduction (P<0.05) after treatment.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. be used for the treatment of a Chinese medicine preparation for periodontitis, it is characterized in that: crude drug is made up of Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici;

The weight of each crude drug is respectively Rhizoma Drynariae 53g ~ 63g, Fructus Viticis 20g ~ 30g, Rhizoma Anemarrhenae 32g ~ 42g, Cortex Moutan 27g ~ 37g, Herba Houttuyniae 31g ~ 41g, Caulis Spatholobi 39g ~ 49g, Herba Ecliptae 35g ~ 45g, Radix Scrophulariae 29g ~ 39g, Semen Cuscutae 34g ~ 44g, Rhizoma Polygonati 52g ~ 62g, Radix Paeoniae Rubra 29g ~ 39g, Radix Et Rhizoma Rhei 31g ~ 41g, Rhizoma Polygoni Cuspidati 33g ~ 43g, Radix Changii 26g ~ 36g, Radix Glycyrrhizae 21g ~ 31g, Radix Gentianae Macrophyllae 16g ~ 26g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 22g ~ 32g, Ramulus Cinnamomi 17g ~ 27g, Rhizoma Curcumae Longae 29g ~ 39g, Herba Selaginellae 36g ~ 46g, Herba Taxilli 27g ~ 37g, Radix Morindae Officinalis 25g ~ 35g, Caulis et folium cryptotaeniae japonicae 33g ~ 43g, Caulis Bauhihiae Championii 22g ~ 32g, Caulis Lonicerae 29g ~ 39g, Fructus Corni 23g ~ 33g, Cortex Acanthopancis 41g ~ 51g, achillea millefolium 22g ~ 32g, Herba Rabdosiae glaucocalycis 27g ~ 37g, Herba Asteris Ageratoidis 19g ~ 29g, Herba Cistanches 35g ~ 45g, Rhizoma Cimicifugae 27g ~ 37g and Rhizoma Panacis Japonici 36g ~ 46g.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that: in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 56g ~ 60g, Fructus Viticis 23g ~ 27g, Rhizoma Anemarrhenae 35g ~ 39g, Cortex Moutan 30g ~ 34g, Herba Houttuyniae 34g ~ 38g, Caulis Spatholobi 42g ~ 46g, Herba Ecliptae 38g ~ 42g, Radix Scrophulariae 32g ~ 36g, Semen Cuscutae 37g ~ 41g, Rhizoma Polygonati 55g ~ 59g, Radix Paeoniae Rubra 32g ~ 36g, Radix Et Rhizoma Rhei 34g ~ 38g, Rhizoma Polygoni Cuspidati 36g ~ 40g, Radix Changii 29g ~ 33g, Radix Glycyrrhizae 24g ~ 28g, Radix Gentianae Macrophyllae 19g ~ 23g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25g ~ 29g, Ramulus Cinnamomi 20g ~ 24g, Rhizoma Curcumae Longae 32g ~ 36g, Herba Selaginellae 39g ~ 43g, Herba Taxilli 30g ~ 34g, Radix Morindae Officinalis 28g ~ 32g, Caulis et folium cryptotaeniae japonicae 36g ~ 40g, Caulis Bauhihiae Championii 25g ~ 29g, Caulis Lonicerae 32g ~ 36g, Fructus Corni 26g ~ 30g, Cortex Acanthopancis 44g ~ 48g, achillea millefolium 25g ~ 29g, Herba Rabdosiae glaucocalycis 30g ~ 34g, Herba Asteris Ageratoidis 22g ~ 26g, Herba Cistanches 38g ~ 42g, Rhizoma Cimicifugae 30g ~ 34g and Rhizoma Panacis Japonici 39g ~ 43g.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine preparation, the weight of each crude drug is respectively Rhizoma Drynariae 58g, Fructus Viticis 25g, Rhizoma Anemarrhenae 37g, Cortex Moutan 32g, Herba Houttuyniae 36g, Caulis Spatholobi 44g, Herba Ecliptae 40g, Radix Scrophulariae 34g, Semen Cuscutae 39g, Rhizoma Polygonati 57g, Radix Paeoniae Rubra 34g, Radix Et Rhizoma Rhei 36g, Rhizoma Polygoni Cuspidati 38g, Radix Changii 31g, Radix Glycyrrhizae 26g, Radix Gentianae Macrophyllae 21g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 27g, Ramulus Cinnamomi 22g, Rhizoma Curcumae Longae 34g, Herba Selaginellae 41g, Herba Taxilli 32g, Radix Morindae Officinalis 30g, Caulis et folium cryptotaeniae japonicae 38g, Caulis Bauhihiae Championii 27g, Caulis Lonicerae 34g, Fructus Corni 28g, Cortex Acanthopancis 46g, achillea millefolium 27g, Herba Rabdosiae glaucocalycis 32g, Herba Asteris Ageratoidis 24g, Herba Cistanches 40g, Rhizoma Cimicifugae 32g and Rhizoma Panacis Japonici 41g.

4. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: the dosage form of described Chinese medicine preparation is powder and oral liquid.

5. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that: when described Chinese medicine preparation is prepared into powder, adopts mode for oral administration, every day 3 times, each 100g.

6. the preparation method of Chinese medicine preparation described in claim 1 or 2, is characterized in that: when described Chinese medicine preparation is prepared into powder, be specially,

Second step, pulverizes respectively by remaining components, mixes by weight, add in cold water and soak 3 hours ~ 5 hours, with slow fire boiling 2 hours ~ 3 hours, the quality of the cold water added was 2 ~ 4 times of the mixture quality that the first step obtains, decoction liquor filtered, filtering residue put into cold water again, with slow fire boiling 1 hour ~ 2 hours, the quality of the cold water added is 1 ~ 2 times of the mixture quality that the first step obtains, merge filtrate, concentrating under reduced pressure, except anhydrating, obtain and get dry extract, be ground into powder;

7. the preparation method of Chinese medicine preparation described in claim 1 or 2, is characterized in that: when described Chinese medicine preparation is prepared into oral liquid, be specially,

8. be used for the treatment of a Chinese powder medicine for periodontitis, it is characterized in that: crude drug is made up of Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici;

9. be used for the treatment of a Chinese medicine oral liquid for periodontitis, it is characterized in that: crude drug is made up of Rhizoma Drynariae, Fructus Viticis, the Rhizoma Anemarrhenae, Cortex Moutan, Herba Houttuyniae, Caulis Spatholobi, Herba Ecliptae, Radix Scrophulariae, Semen Cuscutae, Rhizoma Polygonati, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati, Radix Changii, Radix Glycyrrhizae, Radix Gentianae Macrophyllae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Ramulus Cinnamomi, Rhizoma Curcumae Longae, Herba Selaginellae, Herba Taxilli, Radix Morindae Officinalis, Caulis et folium cryptotaeniae japonicae, Caulis Bauhihiae Championii, Caulis Lonicerae, Fructus Corni, Cortex Acanthopancis, achillea millefolium, Herba Rabdosiae glaucocalycis, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae and Rhizoma Panacis Japonici;